<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHR5</accession>
    <name>A0A3N6LHR5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphonate ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="8">3.6.3.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">phnC</name>
        <name evidence="8" type="ORF">EA462_16495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.28" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86734">
        <property type="protein sequence ID" value="RQG86734"/>
        <property type="gene ID" value="EA462_16495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03256">
        <property type="entry name" value="ABC_PhnC_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012693">
        <property type="entry name" value="ABC_transpr_PhnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02315">
        <property type="entry name" value="ABC_phnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="29268" checksum="AD8F3FA3B7A6A1E0" modified="2019-02-13" version="1">MLTVNNLEKVYDTGDRALDDVSVEVSGNEIVSIIGPSGAGKSTFIRCINRLTEPTSGEVYLDGTEITSLSKNELRNTRRDMGMIFQEYNLVERLTVMENVLSGRLGYVGNLSSIRRSFPQKDITEAYQILDRVGLGGLENNRADALSGGQRQRVGIARAVVQRPKIMLADEPTSSLDPETSHEVMELLTDIADERDIPVLINIHEVDLALEYTDHIIGLTNGSLSFEGTPAELDEEARDTIYRDGKSRTSPETDQPTEVTPHEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHS8</accession>
    <name>A0A3N6LHS8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86175">
        <property type="protein sequence ID" value="RQG86175"/>
        <property type="gene ID" value="EA462_17040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="426" mass="46338" checksum="D835EC8E9FCC2A8E" modified="2019-02-13" version="1">MIRSVSVGFVVLLVVLSVAGVSSPTMLTHTAAGDGSETYQTVEEPIAPSTLPISQSDIDSSDFDTTTFEIVVHKNGSATWTFRHEQRLDGSEDESEAEARSTFQAFAEEFESEDAEPGLYQRFTDQALALTDRGNEVTDREMDATDFTRSARIDEQLNPMGIVEMSFVWHGFAAADNGTVVVGDVFQDIYITDDQSILIEADDDLVFQTAEPDPQYVGANLENADSVQWSGEREFLDGHPRVVFEHAEPESGNSNTGPLSSVTGGDDGERSWSSVAPVLGGVILTALASVFVWHRRRGTNADDDHGDVSQISRPAETDAVAADSGGAELRSEPEKGVEAETISDGSLNDDDLLTDEDRVIKLIRENGGRMKQVNIVEDTGWSKSKVSMLLSDMEDEGTISKLRVGRENIISLDGFEPEATKSPFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHU2</accession>
    <name>A0A3N6LHU2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86195">
        <property type="protein sequence ID" value="RQG86195"/>
        <property type="gene ID" value="EA462_17150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="160" mass="18238" checksum="E69ABA55AB47D48F" modified="2019-02-13" version="1">MDIDKTDRKILYLLEKETETNLTHDKIAERIDVSSSTVTNRIQELKNEGILEGFQPKVNYEQAGIPYHVLFVCTVPVEKRRSLAEEALAVDGVVETRELLTGRRNLHVEVVSIDISTVESCSEELESKGIDIDQSDILRRKSTQPFNHIIQEMVDKSNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIJ4</accession>
    <name>A0A3N6LIJ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87029">
        <property type="protein sequence ID" value="RQG87029"/>
        <property type="gene ID" value="EA462_15415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="269" mass="29561" checksum="5B886F14BC9F25B5" modified="2019-02-13" version="1">MKFGNWFDRLTYVVAEAQILVAGVVFSIGAALVIFRPTLPAVPPVAVGMLAATLLFGPALFGFFVWLVQKLRTRNMIEVHHVNAVQDVLEKYYVEPEIWREKAITGPNPYPVNGGGAWAVQEFEWLEDIEELRVKGIWLEETTDTKLLTSKSHMQAIYGKLTESHITLNILRDSVSEFGADIQRALINSMAEARERGKLMDKSAVKDVFESFEDDAAGTTDDDLPTLEPDDLPGEDLGDLADDALEDTPTPDVGMGSGPHRAATDGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIJ8</accession>
    <name>A0A3N6LIJ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87039">
        <property type="protein sequence ID" value="RQG87039"/>
        <property type="gene ID" value="EA462_15475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="192"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="274" mass="31143" checksum="1794C0C819379FBB" modified="2019-02-13" version="1">MIEDIPAVSALEEGETYHRVKLHEKYGGARYRGIAPCKDHPYVFIFTGDSGEEHGYLDEFRGDTFVYTGEGREGDMEMTQGNKAIRDHREDGREIHLFESNEEAWSVTYVGQFEYADWFPQRLEDTNGNYRKAICFELEPVDNNVEIETYDLGQLDLETLHERAAGTSAAESTEGKTTTTTRTTHPRSEAVKEYALRVADGVCQGCEEHAPFIGKDGEPFLEVHHLYRRSDGGPDHPDNVVALCPNCHQRVHHGQDGDDFNQQLIERSKTPEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIY5</accession>
    <name>A0A3N6LIY5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87966">
        <property type="protein sequence ID" value="RQG87966"/>
        <property type="gene ID" value="EA462_13995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="271"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="416"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="612" mass="67203" checksum="3E39861A7783F9B3" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ42</accession>
    <name>A0A3N6LJ42_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit alpha/FixB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87861">
        <property type="protein sequence ID" value="RQG87861"/>
        <property type="gene ID" value="EA462_13435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="317" mass="33742" checksum="6313A0542C9AA31C" modified="2019-02-13" version="1">MTDVLAVADHRRGELRDVSYELITAGHALADDTGGDLHVAVVSGTVDEFAEKCNREGVNVIHTIEYGKEFDHGVYTQAIVQLADELDPQYVLLPNSVNGLDYAPAVASRLDVPIVTDAIGLENDGETLVATREMYGGKVETMTELKEPAVATLRGAEWPAAERTGDATVEAFDVDIDEDALGTTVNGFEEVASGDVDISEADVLVSVGRGIEEEDNLEIIHKLADALGATVSSSRPIVDNGWLPKNRQVGQSGKVVTPDVYIAIGISGAVQHVAGMKGSDTIVAINTDPNAPIIDIADYAIHDDLFDVVPELIELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK25</accession>
    <name>A0A3N6LK25_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86718">
        <property type="protein sequence ID" value="RQG86718"/>
        <property type="gene ID" value="EA462_16410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="277" mass="29971" checksum="19BAC729B3F5A22C" modified="2019-02-13" version="1">MTETTSTDSDRSPLFGSTGRLTTVGSRTRDTLVNYAPVLALFVAWELAGIVNALPYYLPAPSVIVQEIFELLQDGVLVPNASASLQLVYVGFFGGAALGILSGLVTGRVDTLGKLFDPLISITYPIPKIALFPIFLIWFGLGFTSKVVVVFLAAFYPTYIYTYDGAKGVNDLYIWSARNFNASRTRVFLTVVLPSCLPQILSGLRVSLALAFVVIFSVELIASQIGLGSLIVSAQQSNNFELMFASIAVIGTLGFVHDRALLLVRNRILSWNSGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK45</accession>
    <name>A0A3N6LK45_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89123">
        <property type="protein sequence ID" value="RQG89123"/>
        <property type="gene ID" value="EA462_12180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="169" mass="18540" checksum="297AF454F89C3B1F" modified="2019-02-13" version="1">MFQTDGRTRLPRAIVRSGSESVDERLYKLIALATVFGIGHHVDHLIRGNHVGWPVIPEVTPFTYTLAIYPLLAIGLYLTLTERAGAGYWVVLLGAIFVVVTLSHFGPWATEPPQDVIGPYDHVAVGYVALAWLLGLVGTLLAATVYAGHRWRSARKSTSVERSPPRPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKF9</accession>
    <name>A0A3N6LKF9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">30S ribosomal protein S24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rps24e</name>
        <name evidence="7" type="ORF">EA462_14710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86908">
        <property type="protein sequence ID" value="RQG86908"/>
        <property type="gene ID" value="EA462_14710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_S24e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_S24e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="PTHR10496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="105" mass="11861" checksum="FC532BD538C49A95" modified="2019-02-13" version="1">MDVDIISESENPMLHRTDVTFELAHDEATPERLQVRDSLAAKLNKDAAEVVIRKLDTKFGMRKTVGEAKVYESAEFARDVEQDHMLERNKIVADEGEGETEAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKI5</accession>
    <name>A0A3N6LKI5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine/betaine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86948">
        <property type="protein sequence ID" value="RQG86948"/>
        <property type="gene ID" value="EA462_14925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OpuAC" evidence="2">
        <location>
            <begin position="34"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="307" mass="33906" checksum="90A560568792B7A3" modified="2019-02-13" version="1">MRDSITRRGVLAGAGAGAIGTSLSGCLGMLDDDSIGVSSKEFSEQFILANISQELLEADGHETEDSTGLGGTMANFEALRNEEVGLYWEYTGTAWLNILEHEEPIDDSEELYQQVAAEYEDDFGIEWLEPAPFNNTYVIVSNDDWVDETGVSDLEELSEHAQAGNTDFSVGMNPEIEDREDGWAGLPDTYEFEESADDIETVNMDLGLAVQAVDEGEVDVAFAFETDAEIERYDLEVIDDTRNHFVIYNPAPNVRQDVLTEDIRESFNSVTPELDAETIRELNGRVSIDGDDPGNVAHDFLETNGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLP7</accession>
    <name>A0A3N6LLP7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPFH/Band 7/PHB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89943">
        <property type="protein sequence ID" value="RQG89943"/>
        <property type="gene ID" value="EA462_08000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="36"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="369" mass="40831" checksum="FEA8FB9D08FC59A6" modified="2019-02-13" version="1">MHPIALTARPLQLEVGDPLVIVGALALFLVIATVWSMVEIVDAYNRGALTVFGEYRKLLEPGLNVVPPFVSRVYTFDMRTQTIDVPSQEAITRDNSPVTADAVVYIRVMDAKRAFLEVDNYRRAVSNLAQTTLRAVIGDMELDDTLSRREMINERIRHELDEPTDEWGIRVESVEVREVTPSRDVKGAMEKQTSAERKRRAMILEAQGERRSAVEKAEGDKQSNIIRAQGEKQSQILEAQGDAISTVLRARSAESMGERAVIDKGMDALTDIGQSESTTFVLPQELSSMVGRYGKHLSGSDVQADGTDLESLEFDEETRELIGLDDISEMIGEIEDADVDVEAMEAEAQAIKEGEDVSDSPDDTVGTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM39</accession>
    <name>A0A3N6LM39_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps15</name>
        <name evidence="7" type="ORF">EA462_09085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90133">
        <property type="protein sequence ID" value="RQG90133"/>
        <property type="gene ID" value="EA462_09085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_S15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_S13/S15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_S15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="PTHR11885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S13_N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="156" mass="17680" checksum="0A3FD66C07AAAAD4" modified="2019-02-13" version="1">MARMHTRRRGSSGSDKPTADEPPEWSDVDPEKIEQRVVELAGQGHDPSQIGIKLRDEGVTGVPVPDVKLATGKKITRILEENDADPAVPEDLRNLMERAVGLRDHIRENPQDYQNKRALQNTESKVRRLVEYYRGDELDPDFAYSYDVAAEIIDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMJ5</accession>
    <name>A0A3N6LMJ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit alpha/FixB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89047">
        <property type="protein sequence ID" value="RQG89047"/>
        <property type="gene ID" value="EA462_11750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="317" mass="33361" checksum="466BC90FF20A5CF9" modified="2019-02-13" version="1">MTDVLVVAEHRRGEVRDASYEVITAGRELAAETGGELHVAVISGTVDGFAEKCNRDGVDAVHTVDHGEEFNHGVYSQTVTKLFDELAPQYVLVPNSVNGLDYAPAVANRLGLPIVTDTIDLESDGDALTATREMYGGKVETTVALEGEAVVTIRGAEWPAAEGTGDATVESFDPEIDESALGSNVTGFEEVAGGDVDISDAEVLVSVGRGIDEEENLEIIRDLADALGATVSSSRPIVDNGWLPKNRQVGQSGKVVTPDVYIAIGISGAVQHVAGMKGSDTIVAINTDPNAPIMDIADYAIHDDLFDVVPALTAEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LML0</accession>
    <name>A0A3N6LML0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EA462_11860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89067">
        <property type="protein sequence ID" value="RQG89067"/>
        <property type="gene ID" value="EA462_11860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006996">
        <property type="term" value="P:organelle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022170">
        <property type="entry name" value="MUL1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12483">
        <property type="entry name" value="GIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="GIDE" evidence="14">
        <location>
            <begin position="80"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RQG89067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="250" mass="26846" checksum="1875A976CBD2962B" modified="2019-02-13" version="1">MDLVSLAIGGILAALGVAGIWTGTSSLRQWRRLGADDPVPVREAISRSGSVEVEGAVREHETTLESPVMDESCVAYEYTIEQRRNRGGKRSGSRWRTIEDGTDRRPFVLEDESGRAYVDPDGASLSLERERTRNPNGDSPLPGFLRSLNVDFSINIGGPFGAGIGNRRYTERRLDLDGHCYVVGQAERSPAGIDADVAIVGGESPTFLISDATEGETRRRLLLRGSGFGLAGVGCVALGLWILVSTGVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMM0</accession>
    <name>A0A3N6LMM0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90298">
        <property type="protein sequence ID" value="RQG90298"/>
        <property type="gene ID" value="EA462_09990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="166" mass="17886" checksum="A3C852143730DF37" modified="2019-02-13" version="1">MTLLVPFDASTLATNALAKAATFGELLEEPVVVLTVLPDDAEYARSRGWITEGEPFDREAIERGLRGRAEDVAPNATFRTERVSSDEPTATATTEVVREIRRVAGDVEASVVFIGSENAGSVIAPQSSIGSPVANDQRYDVYVVRQPDAEDRPETTGSIRDDGYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMV4</accession>
    <name>A0A3N6LMV4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_12695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89217">
        <property type="protein sequence ID" value="RQG89217"/>
        <property type="gene ID" value="EA462_12695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="78"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="357" mass="39209" checksum="0B26B2ECF48324A0" modified="2019-02-13" version="1">MYRDHSIGVVVPAYNEAGFIGDVIREMPAYVDSVFVVDDCSSDTTWDDVLEAARVDSNQHDGQPPRDTQSSDVPLATDGSGSVLARRATVHDAVGRVTPIQHHENLGAGGAIKTGYLAALEDGLDVTATVDGDGQMDLSQLSRLLDPIVDDDADYSKGNRLLYPEYRGAMPTFRFVGNTILTFLTKIASGYWKTMDPQNGYTAISHQALATVGVENMYEYYGYCNDLLVKLNVNGMRVADVAMPAVYGDEESSITYTRYVPNVSAMLFRNFLWRLKAKYLVLDFHPLALFYLLGAGTIGVGALGFSWTLYAKYALNDPLFVRTASSLLLVSIGSMFITLAMVFDLKESEDDEMAVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LN37</accession>
    <name>A0A3N6LN37_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YihY family inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_15150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86985">
        <property type="protein sequence ID" value="RQG86985"/>
        <property type="gene ID" value="EA462_15150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="433" mass="47247" checksum="1FCC4A717F5804D4" modified="2019-02-13" version="1">MVDHRQGLELVTRVVRVARTEQLTLLSAGVAFYGFISLVPLMLLGLGIAASIGGETLANQLTTAASDVLTPSAQELLAETVLDDTGRQSATVLGALGLLWGSSRVLRGIDRAFSQVYGTSTSKSLLDTFWDAMIVFLVISAGLAIIAVVEVVIRFLPVVELGPLGPILVLLGLVATFLPLYVVFPDADVDLREAIPGTILAATGWFVLSRAFSLYTEFATGYAVYGALGAVFLVLIWLYAGAIILVFGAVLNATLAGREVDRQLQSPGARQVPLEAMTDDATGADDETTQDRSDARDRTATHSSARTRDRSDDPEALREEIERLRDRIDSFEDNVERRTVEKESLEGELKRYVRRRIRRGHVRDWGPYVVLLYGTAMAIAAFYFLEGIWAILAMFVVWTSTLGVYVLMVLFGAGLSVLDVPGRIRDFVGNRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNX6</accession>
    <name>A0A3N6LNX6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91108">
        <property type="protein sequence ID" value="RQG91108"/>
        <property type="gene ID" value="EA462_03670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="199" mass="22086" checksum="D8829DBF050AA024" modified="2019-02-13" version="1">MMEFDGEFDLENVPPEKAWIVLSDPVAVRNSLKGCRYIAPMDDDFNFDEYEPDEDLETLPEADAEVVAARAFEEGGTYAALMQVGVGSVKPRFETTVTIDERDDETFEMIASGSGDASSSSFSMSSGMRIHELEDGDGSRIEWWTEADISGRIAQLGSRVIQPVATKIVNNFFSSIEQQMTDVDEETDSGVTDRLRNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPP3</accession>
    <name>A0A3N6LPP3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH dtxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88854">
        <property type="protein sequence ID" value="RQG88854"/>
        <property type="gene ID" value="EA462_10665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="1">
        <location>
            <begin position="556"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="620" mass="69970" checksum="5BEB54BC2DC0905D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ22</accession>
    <name>A0A3N6LQ22_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-phospho-L-lactate guanylyltransferase</fullName>
            <shortName evidence="1">LP guanylyltransferase</shortName>
            <ecNumber evidence="1">2.7.7.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">cofC</name>
        <name evidence="2" type="ORF">EA462_06810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:63424"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:59435"/>
            <dbReference type="ChEBI" id="CHEBI:59906"/>
            <dbReference type="EC" id="2.7.7.68"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CofC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.68" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91653">
        <property type="protein sequence ID" value="RQG91653"/>
        <property type="gene ID" value="EA462_06810"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043814">
        <property type="term" value="F:phospholactate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02114">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002835">
        <property type="entry name" value="CofC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392">
        <property type="entry name" value="PTHR40392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01983">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03552">
        <property type="entry name" value="F420_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="226" mass="24023" checksum="7CFBE77E864550E9" modified="2019-02-13" version="1">MQVVVPFAAETPKTRLRSVLSAAERSRFARAMLADVLEALARTGHDLTVVATSPLSSDDDLVGVPSTVRVEVDDRPLTDAVDARLPRRGRTGEPVAVVMADLALATPESLEGLFGPDADVVIAPGRGGGTNALVVRHPDFRADYHGASYLDHRAAANGVGASLETIDSFRLGTDIDEPADLVEVLIHGTGRSPECLRALGFELERTDGRVDTERSLDSTSADSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ35</accession>
    <name>A0A3N6LQ35_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamyl-tRNA(Gln) amidotransferase subunit E</fullName>
            <shortName evidence="6">Glu-ADT subunit E</shortName>
            <ecNumber evidence="6">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gatE</name>
        <name evidence="8" type="ORF">EA462_07120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GatB/GatE family. GatE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90347">
        <property type="protein sequence ID" value="RQG90347"/>
        <property type="gene ID" value="EA462_07120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00588">
        <property type="entry name" value="GatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004414">
        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="PTHR11659:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00134">
        <property type="entry name" value="gatE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="7">
        <location>
            <begin position="479"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="624" mass="66947" checksum="CBEB8C0E4CB3F49D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ59</accession>
    <name>A0A3N6LQ59_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-phosphopantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphopantothenate synthetase</fullName>
            <shortName evidence="1">PPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27930"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal phosphopantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.36" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90377">
        <property type="protein sequence ID" value="RQG90377"/>
        <property type="gene ID" value="EA462_09165"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02224">
        <property type="entry name" value="PPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002855">
        <property type="entry name" value="PPS/PS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038138">
        <property type="entry name" value="PPS/PS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40695">
        <property type="entry name" value="PTHR40695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02006">
        <property type="entry name" value="PPS_PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004853">
        <property type="entry name" value="UCP004853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="193"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="258" mass="28069" checksum="64C7E507141661F6" modified="2019-02-13" version="1">MSDYDTVSADVEHEDEIPEDHPRYQDLLTRHRIEKGVDKGITHLQGMHAEGRGSAFDYLLGEETIPSANDAERAAAAELLLAERPVLSINGNVAALVPGEMVDLADAVGADLEVNLFNRTPERIAAIASHLREHGAEEVKGLEGDARIPNLDHQRAKVDADGIYAADVVLVPLEDGDRAEALDEMGKTEIVIDLNPLSRSPQVAEVPIVDNIVRAVPNMTEHARELAGSNEDALRTIVDEFDRTKALEAAESRIRNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQI8</accession>
    <name>A0A3N6LQI8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89234">
        <property type="protein sequence ID" value="RQG89234"/>
        <property type="gene ID" value="EA462_12785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="763" mass="81151" checksum="15A27971B9926945" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRT2</accession>
    <name>A0A3N6LRT2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91157">
        <property type="protein sequence ID" value="RQG91157"/>
        <property type="gene ID" value="EA462_03950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="142" mass="15634" checksum="C8B9E5884BDBF0AD" modified="2019-02-13" version="1">MRLELRVCQHCLDGDHAGHHKSTLLQDMVNCAERIEEYKHVLDLDAVHIRTVRDDEPGKPEALPVVSATIQNDQIVLNDTQLVAEGQDGHMLLYAHPDDILTVLAGNVDEISKAVNEDVTVELSDPGAKIVSQANLGANRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS42</accession>
    <name>A0A3N6LS42_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_08620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90054">
        <property type="protein sequence ID" value="RQG90054"/>
        <property type="gene ID" value="EA462_08620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="325" mass="36769" checksum="C7109A835CD0D66B" modified="2019-02-13" version="1">MSLKKYVVRRIGQLIVTYWAFLTLLFVVFRLAPGDPTSMYLQEGLSAQERQEILARHGLDQPLHIQYVEYMAQYLTGDLGQSFRHGVPVWDVLVVRFFNTIILMGLAFSIAYVIGVTVGAFIGWVRGTRKEKAGIIVTLVARSSPEFWIGILTLMVFTFYLGWFPSGGIRPPGMEYESFLGRYVNWGVAHHLVLPVLTGVIYYMATPTLLMRSSMINVLNSDFIQIKRAEGIPEYIILYKHAARNSILPMTTVVALVVGMSIGGSLVIETVFSWPGMGREMVESVTYNDYPLAQAIFFLMGSIVIWMNFVADLAYVYLDPRVRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS48</accession>
    <name>A0A3N6LS48_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91327">
        <property type="protein sequence ID" value="RQG91327"/>
        <property type="gene ID" value="EA462_04920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="154" mass="18100" checksum="5760879DD2AAF578" modified="2019-02-13" version="1">MNVVICGPPGTGKTTTTTELGRRLEKDGTPVRNYHSDDFSRRTYDRLYEQVRNAPDEGFCLIDGTFYRREWHTLFRTLEPVRFVRLTASLETCLERNRHRDDAIDEQGVQVVYREFEPPEADLVIDTDERTPRETVDRITSRLRIWQESPRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS92</accession>
    <name>A0A3N6LS92_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90124">
        <property type="protein sequence ID" value="RQG90124"/>
        <property type="gene ID" value="EA462_09030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="177" mass="19219" checksum="20816F2329E77B35" modified="2019-02-13" version="1">MQPVVHLIIGYLCYAVYTRWQRDEVPTDRGALVAIVAAALPDLVDKPLAAAGVVPVGRTVGHSLLVVVPVTLAVWLAADRYGRRTLGTAFAIGLLSHVVTDVPWHVLSGEFHELGFLLWPITEMPSYIGIKPLGTVPILGVEATTLWLEAVIFVVGVALWIRDGKPGFDPIAERLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSC4</accession>
    <name>A0A3N6LSC4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92808">
        <property type="protein sequence ID" value="RQG92808"/>
        <property type="gene ID" value="EA462_00845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043901">
        <property type="entry name" value="DUF5787"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19100">
        <property type="entry name" value="DUF5787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="326" mass="36343" checksum="538064EB53EBDBFB" modified="2019-02-13" version="1">MSEFAFELELCAHLESRVEGILSRQLGASVADPGGRILDVVCVDSGPEFSERTAITNETIPDAAIESAVGTGRARYWKDAFSCHPDQARRAMERACEIGFFESERRNGREYVRQVARYPDWYDRIVGIENKPDLGRPGDLEAQLRTDASLALVDEIVLATESYVTRAHLHRIPDSVGVWRVHRDDDPGELEIEEIREATPLSVDGSGIEPLAYRPGRTEIAVVSAEEKARARRRLAERSYGKGWRTYDFPACDSCSPTTASGSTLPFCAWAGRAVHSDSECGPSCPGYDPAPDPAIDLEAERDRRTRWCREPEGKRRRQSGLDRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSC6</accession>
    <name>A0A3N6LSC6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_05630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91447">
        <property type="protein sequence ID" value="RQG91447"/>
        <property type="gene ID" value="EA462_05630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="395" mass="42180" checksum="89DF2D88DBC12353" modified="2019-02-13" version="1">MECTSEDCEGPESVSHCANRSPAYFTAAVVPSAVFRLVRAVSKITLVSVVLFVTALTASAKAHEEYVVDDERDVTATEFLADALVDPAVVGPLIVGAAGVVAVVAGYLFVRPLQRDIGAFRSAMREYTDYVPWLLRISLGIPLIGAGFSGYFISPALEVDLRLLQVTLGFLLLFGLGTRIVALAGLVAYLVGVFRWPTLLLQLEFVGGFVAIALIGSGRPSADHVLQRVAGTTGTAYRRLDPIHERSRSFRERIGTTERYLPTVVRVGLGVTFIFLGATQKILQPGLALGVVDRYDLTAVVPASPELWVLGAGLAEVALGIALIVGLFTRATAAAAVAMFTLTLFALPDDPVLAHVALFGMASVLLITGGGPFALDNRLERFENPTTDTRIDEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT42</accession>
    <name>A0A3N6LT42_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IMP cyclohydrolase</fullName>
            <ecNumber evidence="3">3.5.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">IMP synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Inosinicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purO</name>
        <name evidence="5" type="ORF">EA462_02930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal IMP cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.10" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93173">
        <property type="protein sequence ID" value="RQG93173"/>
        <property type="gene ID" value="EA462_02930"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00705">
        <property type="entry name" value="IMP_cyclohydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010191">
        <property type="entry name" value="IMP_cyclohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020600">
        <property type="entry name" value="IMP_cyclohydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036795">
        <property type="entry name" value="IMP_cyclohydrolase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07826">
        <property type="entry name" value="IMP_cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004866">
        <property type="entry name" value="IMP_cclhdr_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75569">
        <property type="entry name" value="SSF75569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01922">
        <property type="entry name" value="purO_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP_cyclohyd" evidence="4">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="196" mass="20966" checksum="790D48ED36B6EC90" modified="2019-02-13" version="1">MYVGRFVVVGPEVGAYRVSSRSFPNREISARDGALTVGPTADAPETDNPYVAYNCLRVVETPTGETVAFGNGSQVDPIAEKLELGYPARDALAECLLALDYEKDDYDTPRIAATISGDGEALVGTVRKDALLVETVDEPTLVATYEKDTPEPFEFDVETAGEAASEAYDLEFEHAVCAAGVSRTENGFVTALENGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT84</accession>
    <name>A0A3N6LT84_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93233">
        <property type="protein sequence ID" value="RQG93233"/>
        <property type="gene ID" value="EA462_03295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="190" mass="21967" checksum="2148C89C7143118A" modified="2019-02-13" version="1">MTGRKNAMLTTEDRRWLTGEKSYEGEHAKQQRYQRRRDIRERVYNSLLDFTILFEYLEADEREKLFGTAGTKQTTLTDDRKLSNGVRDAFAFLLYSTGIDARLGTDANRPSPVADQLLTEAFHRVGRRESVLVQNVDIDIDVVELPRESLLEDLAAGNELSSHELKILLESEDVDTREVQEHIRRQVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUN2</accession>
    <name>A0A3N6LUN2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91274">
        <property type="protein sequence ID" value="RQG91274"/>
        <property type="gene ID" value="EA462_04600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="140" mass="14699" checksum="AF5538EFB248D788" modified="2019-02-13" version="1">MYQDLLLATDGSDGAQRATDHAIALANRLDARVHVLSVAEEGPHSTEQRDRLRADPESEAIEAVEKADTAATTGGVETTTTVRSGVPQEQIVDVAEANEIDMIVIGAVGRGKLEQLVVGSVAQEVVRTASVPVVTVRDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVV1</accession>
    <name>A0A3N6LVV1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dihydrolipoyl dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_01465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92917">
        <property type="protein sequence ID" value="RQG92917"/>
        <property type="gene ID" value="EA462_01465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="4"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="364"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG92917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="491" mass="51806" checksum="8424FDC4F487DF5B" modified="2019-02-13" version="1">MTEYDIVVIGGGSGSQVATAAADSGLEAAVIERGPLGGACITRGCVPSKALIHRADVAEELRRAPEIGLDAALEGVAYAEITSSIRDWVYERAARQERSLEEADGVALYRGEGRFVDERTLAVDSNGDETDGDVPDPIRGDHVVVAVGSRPLIPPIDGLGAVDFLTSDDALFLDERPDSIVIVGGGYIGAELGYFFGALGADVSLIGRSDVLVPREDGAISEFVTESLERYCDVYAGHEAAAVEAEDGGVVVTAERGENGDGEDESPDGEGRGESVDLEADRLLLATGRRPNTDTLDLEETGVETDGRGYVETDSILETACDGVWALGDVLGEQPFKHAADYEARVVAANVLEDAGHEVEYEAMPRAIFTSPQVASVGETEDELENADREYESTTVPFDVAPLGVVLEVDGFVKVLASPNGEILGCHVVGPQASILIQEVVVAMERGSGTVDDVAKPVHVHPALSEVVYAAFDELSSNRYSTAPDWRDVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LW30</accession>
    <name>A0A3N6LW30_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH iclR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93017">
        <property type="protein sequence ID" value="RQG93017"/>
        <property type="gene ID" value="EA462_02050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="111" mass="12509" checksum="AD89BA31FD53B11E" modified="2019-02-13" version="1">MSRNSEDREIAETLIDQHGSEILTAASKEPVAVRNIVEETEMSRATAYRRVEALNDSGLLEKVGQVDETGTQYHVYQAAFESIKLEIVNGITYVHVIRDDGHDLTQISDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWJ4</accession>
    <name>A0A3N6LWJ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93217">
        <property type="protein sequence ID" value="RQG93217"/>
        <property type="gene ID" value="EA462_03215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="145" mass="15769" checksum="768BCF8C7DB314D6" modified="2019-02-13" version="1">MNVRDALEADADALAAIADSPTDVMRNLVHDRTVRVAEDGSHDPNADVSSSQYDGSNPEDLLGFISFDAREDTVHVTQIGGTEAACEQLLAEPVRFAERESMAVEMLVATDTDSIRDAAEELGFTRQGTGPRFDGARTDRFRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYI9</accession>
    <name>A0A3N6LYI9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L10e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl10e</name>
        <name evidence="6" type="ORF">EA462_01560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92934">
        <property type="protein sequence ID" value="RQG92934"/>
        <property type="gene ID" value="EA462_01560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00448">
        <property type="entry name" value="Ribosomal_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_L10e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022981">
        <property type="entry name" value="Ribosomal_L10e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_L10e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="PTHR11726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="5">
        <location>
            <begin position="13"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="176" mass="19838" checksum="7F15C21862D452D5" modified="2019-02-13" version="1">MSDKPASMYREITKPAYTRREYITGIPGSKIAQHKMGDITADADDYPVQISLVTEEEVQIRHGSLEASRLSANRYMLKNAGEGNYKMILRKFPHHVIRENKQATGAGADRVSDGMRQSFGKIVGTAARIDRGDRIFTIWCDVDDAEFAKEAFRRAYNKITPPCRIVVEKGEEELIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYW4</accession>
    <name>A0A3N6LYW4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">speB</name>
        <name evidence="5" type="ORF">EA462_02385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93074">
        <property type="protein sequence ID" value="RQG93074"/>
        <property type="gene ID" value="EA462_02385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="282" mass="30561" checksum="242A38C456ED2B46" modified="2019-02-13" version="1">MFPGAIDEREVTDASGRSDREDANFVVVGAPLDVSTTFQPGTRFGPRRIRTYAETFDDYDRRTDQYFSDLGVVDHGDVYAWDDADAYLEFLAGTLRDVVWDDAVPVTLGGEHTVSLAGVRAVEPEVFVCLDAHLDLREEYDGNRLSHACVTRRVLEDVAAVEEAIIVGARTGSEDEWGRAAGDDVTVIAPEDVGAVDIAERVGSRTCYLSVDIDGADPAYAPGTGTMEPFGLEPREMRDVVRRVGSRAAGFDAVEVNDRDDGQAASLAGKLAREFVYASAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ15</accession>
    <name>A0A3N6LZ15_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86992">
        <property type="protein sequence ID" value="RQG86992"/>
        <property type="gene ID" value="EA462_15205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="15315" checksum="67B4BBE0CEE46A4A" modified="2019-02-13" version="1">MTADDPSVIRSLAISTTDIVDAYAYTQENPGTAVIRVTPPFHGRMRARIHVYRIDDVEHTDAIHVSPADLIEDDVVDSYPGYEDELAREGEGTSPPKSGGFGNRRAAAVDGWRARARDAIVDTVSLGEDDARHGVVVKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZS2</accession>
    <name>A0A3N6LZS2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88800">
        <property type="protein sequence ID" value="RQG88800"/>
        <property type="gene ID" value="EA462_10365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="156" mass="17538" checksum="9038A65633CFCE07" modified="2019-02-13" version="1">MSNTVASVSGVDMPEDEIDSFLEKTGIGTLSFGTEDGGYAVPMSFGFDRDNQRCLFQFVSDDDSTKEAHLERSNRVTLTVYEWSEVDDWRSVVLRGSLDELPDDELYDAADTFSDYAVPVSLSIFEKKATELDFSWYTLDVRSKSGRWAKPIETDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M082</accession>
    <name>A0A3N6M082_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87934">
        <property type="protein sequence ID" value="RQG87934"/>
        <property type="gene ID" value="EA462_13815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="261" mass="27964" checksum="4E204B09E8FD929F" modified="2019-02-13" version="1">MRLRNRTVVVTGASNGLGKAIATACTEEGARVVCASRSAEKLDALAADLTERTDEGNAVAVPTDVRSWDDVRSLVAETTDRFGGIDVFVNNAGITQLNVAGEPSYRPVSDVPVDAWDAILETNLRGPFLCSKAALPGMKARGSGRLIHVSSGHGLRARANRSPYVASKFGLEGLHETLTRELEETEIDSIALRPPNGGVYTERKGENETTKETYRHESPTVISETAVRLAADEGEHGGRYVANADGDSYSTYTTGDDPRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0F3</accession>
    <name>A0A3N6M0F3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_14305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88024">
        <property type="protein sequence ID" value="RQG88024"/>
        <property type="gene ID" value="EA462_14305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="30"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG88024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="568" mass="62148" checksum="AECC00AA688DC108" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0J1</accession>
    <name>A0A3N6M0J1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_14595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88074">
        <property type="protein sequence ID" value="RQG88074"/>
        <property type="gene ID" value="EA462_14595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG88074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="552" mass="59974" checksum="83A1A3978EC32FB5" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1X6</accession>
    <name>A0A3N6M1X6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89790">
        <property type="protein sequence ID" value="RQG89790"/>
        <property type="gene ID" value="EA462_07160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="56"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="316" mass="33272" checksum="9DD28FFCD0C3F57E" modified="2019-02-13" version="1">MRLEYLWDETTNEIVRDAVGPAAPAFELLTHLGDGAVLLVAGILIYWFGARGNRRKRAFVIAVGTAALALSAGMKGIMEIPRPELAFSPDGYPGFTFPSAHAMGAAAFYGALAVSMERGTKGIRYLMAGAIITVVAVSRVVMGVHYAGDVVVGVGLGLALVGVGLWVREEELFDPGPLFLIATAIAVVAALLGSRVFVTLTLGASIGGTIGWYYVRNRRTTTVGASILVLGLVGIGGIIALRGLSALIGYGVSGGTNTTGVLVLEVIAYATLTATVMAVPHFGLRIEQRPSVRWLQETLPFRGRIIGPEKSFTRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3D7</accession>
    <name>A0A3N6M3D7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cobyrinic acid a,c-diamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbiA</name>
        <name evidence="7" type="ORF">EA462_10150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:26289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="ChEBI" id="CHEBI:58894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.11" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90390">
        <property type="protein sequence ID" value="RQG90390"/>
        <property type="gene ID" value="EA462_10150"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="236"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="437" mass="46298" checksum="42936F34EC32C437" modified="2019-02-13" version="1">MKGFVVGGVSSGVGKTVATLAIGRALIDDGYAVQPAKAGPDFIDPSHHEAIAGRPSRTLDRWLEGTEGLRRNYHRGEGDVCVVEGVMGLYDGDGSSTAMVAEALDLPVVLVVDAKAGMESVAATALGFREYAETSGREIDVAGIVAQRAHGGRHEQGIRDALPADLEFFGRIPPNDDLEIPDRHLGLEMGGEAALPADALREAADSLETERLIEVASEPPTPSTNGRDESGRVDARVAVASDSAFCFRYPATIERFRERGEIVSFSPVAGDPVPECDGVYLPGGYPELHAADLESTGTLSELGALASDGLPVLGECGGLMAMSQSLTTAEGDRREMAGILPADVTMRDRYQALDHVELDALSGTLTAASGQRIRGHEFHYSSADIDGDARFAFETVRGDGIDGDHDGLTEYDSLGTYVHVHPESGAFDRFLETVESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3G8</accession>
    <name>A0A3N6M3G8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4870 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86647">
        <property type="protein sequence ID" value="RQG86647"/>
        <property type="gene ID" value="EA462_15990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="147" mass="15830" checksum="90C70213A03ED0F3" modified="2019-02-13" version="1">MTSTSTASGPELLEERSIGGILVHLLGLLTGFLGPAIVYAVSDDEYTRTNARHALNWHVTVLALMIVSFVTFFLGADELTVGGEQTELSLLPAPLDTVFAIAGVLLLIVFMLAILLTFVYAVVATLKAVFGSIWTYPGAIDVVKRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3M4</accession>
    <name>A0A3N6M3M4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89801">
        <property type="protein sequence ID" value="RQG89801"/>
        <property type="gene ID" value="EA462_07215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="27"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="218" mass="23866" checksum="8AFD0E2491527DA3" modified="2019-02-13" version="1">MSQQKSDFVAETEIDATLDELPTDEAIEETVNNLESNGFDVVVTDSAEDVLEVLQARIPADASVMNGHSTTLEEIGFDEHLSEGDHEWESLADEVWSINDDAKRQAARRESQTADYFLGGINAISQTGELVAADRSGSRIGAYPFAASNVVIVSGVNKIVPTLEDALDRLESVAYPLENERAKEAYGVESAIAKQLIYRQELEDGRTTVVLVRDQLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4C0</accession>
    <name>A0A3N6M4C0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aspS</name>
        <name evidence="9" type="ORF">EA462_15290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87007">
        <property type="protein sequence ID" value="RQG87007"/>
        <property type="gene ID" value="EA462_15290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="99"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="189"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="405"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG87007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="434" mass="48487" checksum="AEEAAD474CA7B45E" modified="2019-02-13" version="1">MQDRTYTADAEPGDDVTVAGWVHEIRDLGGIAFLILRDATGKIQIKFEKDEMDDDLVETGLGAARESVVSVSGAVEEEPRAPTGVEVTPESVEIVSAADPELPLDPSGKVDADLSTRLDNRTLDLRKDQVQAVFEIRSEIMRAVRDRFREYRCTEINTPKIVATGTEGGTELFPITYFGEEAFMNQSPQLFKQLIAGSNVERVFEIGPIFRAEEHNTPRHLNEATSIDFEGAFCDEADAMDVAEGIVTAAYEAVVENCSDELKALGLEDDFAVPDGEFPRISYEEAIERINATGELDDQLVWGDDLSTEAERALGQDVGGHYFVTDWPSEIKPFYIQDHDDDPDLSTGFDLMHPRMELVSGGQREHRHEKLIEGFEQQGLDPDQFEYYTKMFRYGMPPHAGFGLGGERLVMTLLGLENIREAVLFPRDRQRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5Y4</accession>
    <name>A0A3N6M5Y4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytidylate kinase</fullName>
            <shortName evidence="5">CK</shortName>
            <ecNumber evidence="5">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytidine monophosphate kinase</fullName>
            <shortName evidence="5">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cmk</name>
        <name evidence="7" type="ORF">EA462_05590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytidylate kinase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91440">
        <property type="protein sequence ID" value="RQG91440"/>
        <property type="gene ID" value="EA462_05590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00239">
        <property type="entry name" value="Cytidyl_kinase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011892">
        <property type="entry name" value="Cyt_kin_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02173">
        <property type="entry name" value="cyt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="192" mass="21752" checksum="F23A913F8BE2A40E" modified="2019-02-13" version="1">MLLTVSGPPGSGKSTTAQLVAETFDLAHVSGGDIFRELADERGYTPLEFNKLAEENEQIDRDLDRRLREIALEEDDLVLESRLAGWLAGDEADFRFWLDAPARVRGERIAEREAKDPERATEETKAREASEAQRYEQYYGIDIQDLTIYDLSVNTARWEPDAVLDMLVTAVDEYDTDGDEGKAPVLLDYEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M686</accession>
    <name>A0A3N6M686_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_06275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91560">
        <property type="protein sequence ID" value="RQG91560"/>
        <property type="gene ID" value="EA462_06275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="69"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine_deam_C" evidence="6">
        <location>
            <begin position="419"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="590" mass="61789" checksum="361AFDEDC85AA32A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7A9</accession>
    <name>A0A3N6M7A9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="2">FGAM synthase</shortName>
            <ecNumber evidence="2">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="2">FGAR amidotransferase II</shortName>
            <shortName evidence="2">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">purL</name>
        <name evidence="6" type="ORF">EA462_04315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91221">
        <property type="protein sequence ID" value="RQG91221"/>
        <property type="gene ID" value="EA462_04315"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="4">
        <location>
            <begin position="60"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="5">
        <location>
            <begin position="194"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="4">
        <location>
            <begin position="441"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="5">
        <location>
            <begin position="574"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="306"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="740" mass="76723" checksum="6743AD31BCA2BF05" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7Z9</accession>
    <name>A0A3N6M7Z9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="ORF">EA462_05830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91481">
        <property type="protein sequence ID" value="RQG91481"/>
        <property type="gene ID" value="EA462_05830"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="314"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="41140" checksum="7CB611D81CAF97F7" modified="2019-02-13" version="1">MKLHEYQAKNVFADAGVPTPASQLASDVDGVLAAAEEIGYPVAVKAQVQVGGRGKAGGIKLVSDEDEAREAAESIIGMDLKGYHVDRVLVEEAVDFTNELYVGITMDRAEGKPVAMVSTKGGVDIEQVAEEDPGAIATEHIDPSFGMHPYQARKAVYGADVDGTVARDVSSVLMTLYDLWESRDGSDAEINPLMVTSDDEVVAADAVMNIDEDALFRQPELAEMEEEATGGDELEQKADEYGFDYVRLEGNVGIIGNGAGLVMTTLDLVDYYGGEPANFLDVGGGAKASRITNALDMVFSDDNVDSVVFNIFGGITRGDEVARGINEALEQFDEIPKPVVVRLAGTNWEEGMEILNEDLVTVEQTLEDAVERTVEYAAEVNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8X9</accession>
    <name>A0A3N6M8X9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uracil-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92710">
        <property type="protein sequence ID" value="RQG92710"/>
        <property type="gene ID" value="EA462_00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="2">
        <location>
            <begin position="49"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="238" mass="26439" checksum="CFD406CB9FAC5B90" modified="2019-02-13" version="1">MSPTGPEPGPDTDSSPSDRDPTVPESRHVLESDCSRCPALVDSRECISWGTGPLDATVVVVGEAPGYGDPDADRWQGGNWTGRAYTSRHSGRRIRRMLERIDYGDDAYYTNAVKCFPTSENSPENARDTPTNREPTAEERSNCRPHLLAELEAVEPDVILATGKHATTTILAAERRQLDGFVDSVLEPVRCERLETWLVPVFHPSYQDIWLNRLGYEPDGYLVAIREAIEDPSTAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9K5</accession>
    <name>A0A3N6M9K5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_01780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92970">
        <property type="protein sequence ID" value="RQG92970"/>
        <property type="gene ID" value="EA462_01780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="308" mass="33476" checksum="3035DD75B4CDC2FE" modified="2019-02-13" version="1">MPAMTVDSLTKSYGRTLALSELSFEVKEGEVFGFLGPNGAGKSTTINVILDFIRPTAGRVSVLGMDAQKRSREIRARTGVLPEGVETYDRLTAREHLEFAIDSKGVDEDPETHLERVGLHDAIDKKAGGYSKGMSQRLMLAMALVGEPELLILDEPSTGLDPNGAREMRRIVREENERGATVFFSSHIMEQVEAVCDRVGILREGEMVAVDSVEGLRDSVSGGESLRVTVDRIDDDAVQAVRSLPDVSSASVDGDAPPTIVVQVDGSKTAVLSELEDRGIDVQDFSTTEASLDDVFRSYTTDREVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9Q4</accession>
    <name>A0A3N6M9Q4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_09870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90276">
        <property type="protein sequence ID" value="RQG90276"/>
        <property type="gene ID" value="EA462_09870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="9">
        <location>
            <begin position="5"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="10">
        <location>
            <begin position="482"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="402"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG90276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="611" mass="66806" checksum="543FD360C1E7B525" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9Z3</accession>
    <name>A0A3N6M9Z3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90386">
        <property type="protein sequence ID" value="RQG90386"/>
        <property type="gene ID" value="EA462_09725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014988">
        <property type="entry name" value="Uncharacterised_YqcI/YcgG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40045">
        <property type="entry name" value="PTHR40045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08892">
        <property type="entry name" value="YqcI_YcgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="30408" checksum="3291497647EA6E15" modified="2019-02-13" version="1">MNEPGIQSLMDQETLDDRIRRGETPRWVRDHWESFRDGLLGRRNGTPFPCFFGAESVANGDPLYTTVPSMSDAEALLTLRDRVLEYLEVYRAHSDRASLVTFFKPPETPLSEREYHESLWHILQTLHLHDPEPWPEEIPTDPDDPYWEFCLGGEPMFPTCRAPFYDARKSRYCPIGLEITFQPRALFERMGVTADTDAGEHAREVIQGRLEGYDGVCPHADLGDWGVEGDREWSQYMLSSDDDQAPETCPITVTREHPKPAARIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MB92</accession>
    <name>A0A3N6MB92_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92731">
        <property type="protein sequence ID" value="RQG92731"/>
        <property type="gene ID" value="EA462_00415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="472" mass="51567" checksum="C5F3B0BB412EDBEC" modified="2019-02-13" version="1">MRRSIVVAVILFAIAFLFIGGPSLLFSPSADDVVPEEQSQEEPEIVSISDSESGFWPYLNAREAHEKRSPLNVVVRGESTEVVRLLAEHGDGDWEEADHDHFEAEDLLDLPDNESETEGTSTSNHTAGSDAADPEAETAVEQLRPVSPTDIPWSHADGATRLAYLDPGPGEETYWTTETLQLEDGEYYGYRYHIRLYESPNPDDQWVVMQTHSEHFDWFTLRHRVDGVEAAQSRLERDLMAIPGVDVQEDVRRIYLDNSGPADADGWATKVDLTAMAIVPFAFGLVARRQSTAEHAGVGIQERADDAIDSRISEHDRERVAAASDRIEANHLILAATIIAVVLGVRIAGIGLDRTVDALTVHMIAALLYPVIAIGLPAVTYAIANGLERRLDAAIAASLSLVVAIWLDYTLLGVDVLPIDVIVQRALVVVALGLIAGGAARRATRDSRLNDMLIAGMMLWILVLGGTLLGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBL6</accession>
    <name>A0A3N6MBL6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminodeoxychorismate/anthranilate synthase component II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92861">
        <property type="protein sequence ID" value="RQG92861"/>
        <property type="gene ID" value="EA462_01155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="234" mass="25413" checksum="8B71D00F9AFFCCC4" modified="2019-02-13" version="1">MTSTEARILVVDNYDSFAYNLVQYVGEVADEVVVRRNDRIDLEDVHDLDPTGIVVSPGPGTPQEAGISIPLFTTSRYPILGVCLGHQALCAANGAPIVHASEIVHGKPSTVSHDGDGIFSGLPETVQVGRYHSLAVGRRDLPDALEETARTTDDRGVLMAVRHRDRPHIGVQFHPESILTRRQDETREGESAGERGQGISLEVGKRMIANFCRFAAAVTDEARSTEETSDEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBZ3</accession>
    <name>A0A3N6MBZ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91206">
        <property type="protein sequence ID" value="RQG91206"/>
        <property type="gene ID" value="EA462_04240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="9211" checksum="248251A5FBD22387" modified="2019-02-13" version="1">MASTARDDRSEGVEFIREDDGSITARDLETGIASFGETKAKALEMLAEALALHEGGGEPVTDDDLREWGLDPDATDDKPLPDFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC12</accession>
    <name>A0A3N6MC12_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91226">
        <property type="protein sequence ID" value="RQG91226"/>
        <property type="gene ID" value="EA462_04340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043827">
        <property type="entry name" value="DUF5804"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19120">
        <property type="entry name" value="DUF5804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="190" mass="21360" checksum="96878FBC7F3A15BC" modified="2019-02-13" version="1">MTRVCLIGDPDCNLQYELLSRETSRDALATYDLRRPFENSIAVRTVSIGAAVSLLNDLDWYLTRFVDEALVQEPSISDEEWLSRSLARALRNGEIDPGETDAFCKIYGLERLEEPATPSGESDESVATDGRETTAEDEAIASESHVPSRSSRRLVEPLYVRRVDGDLPEYDLRDVEETLVVRLTEAEYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC29</accession>
    <name>A0A3N6MC29_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91246">
        <property type="protein sequence ID" value="RQG91246"/>
        <property type="gene ID" value="EA462_04445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="305" mass="33844" checksum="E83B4BCBA7C680F1" modified="2019-02-13" version="1">MDVLTLTTNADAPFMNEQMRVMERRGVSFSTLSVSGDGRAGHSRSPADYLRFLPTVIRESANGYDLVHAHYGLTAPMALSQLRKPVVLSLWGSDIYGPIEPLSRACVPLCDEVVVMSEEMRRYLGRDCVVIPDGVDLEKFQPGPKASARDAVGWDDDGYHVLFPYTPAREVKNYPRARRIVNAVNGLIDEPVRLHTVYDVDHDAIPDYMNAADALLLTSHSEGSPNSVKEALACNLPVVSVDVGDVRTRLEGVEPSHVGTDDDDLVEGLRRVLERDERSNGRERARDVSINRTADRMLGVYERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCP1</accession>
    <name>A0A3N6MCP1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_00115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93271">
        <property type="protein sequence ID" value="RQG93271"/>
        <property type="gene ID" value="EA462_00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="101"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="147"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="272"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="347"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="458"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="596"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="727"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="793"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1006" mass="114989" checksum="B849E24E42D5EA4D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MD76</accession>
    <name>A0A3N6MD76_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91736">
        <property type="protein sequence ID" value="RQG91736"/>
        <property type="gene ID" value="EA462_06930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043850">
        <property type="entry name" value="DUF5812"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19129">
        <property type="entry name" value="DUF5812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="156" mass="16919" checksum="9524AD8C4BC94AE7" modified="2019-02-13" version="1">MSEKTSTFVVTHAEDESAIVRDVETAQVHTLATNPGLEVHDVLEATVAPDPPLEVTWQVIAVENRRSIDLVDTDLEPTQHSKELAAGVDVGELVTEERAGTGAIHVVRVPEDEVDAAAQDVLHDDETIARAARLEAVRVEVRRSADGVVSVRYLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFS7</accession>
    <name>A0A3N6MFS7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92766">
        <property type="protein sequence ID" value="RQG92766"/>
        <property type="gene ID" value="EA462_00605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="151" mass="16580" checksum="57150839ABBDF547" modified="2019-02-13" version="1">MTILAAIGEERHPKKVLETSAELAARYDSRLVVLHVVPRDDFETHKELLEGNSELGGFTIDQEAKSAAEFVRLAVENVLGEFDDESIEARGRVGDPTEEILAEAERTDPEFVVIGRPRTSQLEKAVFGSVPQNILENTDYNVVSTVIGSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGC4</accession>
    <name>A0A3N6MGC4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IIA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92996">
        <property type="protein sequence ID" value="RQG92996"/>
        <property type="gene ID" value="EA462_01940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="262" mass="27569" checksum="B19F5C05F70327E7" modified="2019-02-13" version="1">MSGLDPIGGALVDLDGTVYRGESLIPGADRGIRALRDRGVPVLFLSNNSLKSRAAYADKLTGMGLPAEPADILNSTVISVEYLLREHPRDEIYVIGESHLEGELEAAGLSLTDDSAAVDVVLVSMDRSLDYETLSTALDSIDEETTILATNPDTTCPVEGGEIPDAGTNVAALEAATGRDLDRVLGKPSSITVEAAADRLGVDASQCLMIGDRLETDVRMGVQSGMQTALVLSGVTDRRDLDGSTIQPDVVLESLSDLESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGI8</accession>
    <name>A0A3N6MGI8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93066">
        <property type="protein sequence ID" value="RQG93066"/>
        <property type="gene ID" value="EA462_02335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="227" mass="25347" checksum="50335A9829063A30" modified="2019-02-13" version="1">MTFRVDERATDLREIDRYDRGVGWIAHPDERMQRASHAIDVDGELWVVDPVDADGLDELLVEHGDVAGVVVLLDRHKRDAAAVANRHDVPVYLPRQFDGVSEEIDAPVARFSDELSDTGIEAHTLVDNRFWCEVALYDPADGTLVVPESLGTAEFFVTGSERLGVHPMRRLVPPRAQLEGLSPTRILVGHGPGVHEHAPKILEHALSGSRWRTPRLYAKTAWGMRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGJ6</accession>
    <name>A0A3N6MGJ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_02400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93076">
        <property type="protein sequence ID" value="RQG93076"/>
        <property type="gene ID" value="EA462_02400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="190"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG93076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="372" mass="43461" checksum="52A1631045A9707F" modified="2019-02-13" version="1">MSENPNEIEGIKLVPEPTREILSDRQQIDYTDHREQFIDWLLVFGKNPAQADGYARATTKNSAERLDRFYRWVWSEFGGYTTDITHDHADAYVKDLARKDEGNYSRNNTQSSLKRLFKWQKHERGGELWDPEIVFSEPSGTGEPRDYLTREERSKIREAAFEYGSIPSYNNLSTTERDTWKAYLAQRLSKHKRDVTADDWDRANSWKFPSLVWTSLDAGLRPIEVKRARTSWVDIDNAVLRIPRQESSKNDGNWTVSLQERTAKALDRWLVEREQYDLYADTDALWLTRFGNPYETSSLRQVLKKLFEIAGIPAENRKVSWYIIRHSVGTYMAREEGLAAARAQLRHKSVRTTARYDNAPPEDRRDALDRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGK7</accession>
    <name>A0A3N6MGK7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93096">
        <property type="protein sequence ID" value="RQG93096"/>
        <property type="gene ID" value="EA462_02515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="125" mass="13655" checksum="A5E27BF16D297605" modified="2019-02-13" version="1">MGISKPLIAETPSPRLVAVRHTRGEHVDDRTSAREETEERRLEAEEYALVTGSPDGSVTTPGRFGHAARCAVPGLPLVCSNPRGSFVDTSRSLRSRICVDRTVLTESNANEVSVGHVRTERRSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MH08</accession>
    <name>A0A3N6MH08_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_00445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93276">
        <property type="protein sequence ID" value="RQG93276"/>
        <property type="gene ID" value="EA462_00445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="274" mass="29818" checksum="EC82AFF2A566227C" modified="2019-02-13" version="1">MTGWLRLLVHANLFISLATVSVAVTTMVLVGLSLEFFPLFVVFAATMFVYTVNRFTDLEEDERNVPRRAAFTRRYGRFWLALGIVLYLGAIATAVGLDLPGALYLLLPVPVALLYSLGGLKRIFLVKNCFVGLAWGVIPLGVGYYYGQLADLSVLFLAGYVTVMITIAAVIFDVKDVAGDRAEGIATVPNRLGLRSTRRLSQAANVVVATGVIGLVWTDVLTGEFLVVLAMNGYVAGYIPFATPDRGPLFYGFVVDGEHVFLAGVVLALEWLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MT65</accession>
    <name>A0A3N6MT65_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87975">
        <property type="protein sequence ID" value="RQG87975"/>
        <property type="gene ID" value="EA462_14045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="74" mass="7847" checksum="C04604844B8CDD5C" modified="2019-02-13" version="1">MSSGIVRGTLRRPERNNAPRGASESAGAIERNDGVESVQSLEFVRVGIDTASCTAAQGSESIEERPRSVPSETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUT4</accession>
    <name>A0A3N6MUT4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89162">
        <property type="protein sequence ID" value="RQG89162"/>
        <property type="gene ID" value="EA462_12405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043952">
        <property type="entry name" value="DUF5783"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19095">
        <property type="entry name" value="DUF5783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="122" mass="14281" checksum="BC0704A5312FDA74" modified="2019-02-13" version="1">MADFDPEKFDDKYANYFPELQQAYKNAFNRMNDRYDSKLIHAIDQQVLNESEPFYEGHAERSTGEGNGTEPGDDEGEFRIDLPEDPYDRISGVVVEKNRFEEVLEIYVDEIKAELRRVFGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUV0</accession>
    <name>A0A3N6MUV0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89182">
        <property type="protein sequence ID" value="RQG89182"/>
        <property type="gene ID" value="EA462_12510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="227" mass="22889" checksum="1DC1BAE6593F2FFA" modified="2019-02-13" version="1">MTRKTLLAAILAAAMILSAFAPLGVAAANSDEPTDELSLVVSGDGVVTVTANESPIENVTVGVSTDDNESYAGTGEYSTDVNGTVELPESNESVTVTITASTSTDTVEATATLEPADENDEIDDGDDAPFGSLVSAYVDEQRNESSGPLGVLVANFVLENNPGNASDHAGPPDHAGGQSSDDEHDQGPPDHAGGPSDDDEHDRGPPDHAGGPSDDDDGGPPGQAGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N034</accession>
    <name>A0A3N6N034_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recombinase RecA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91222">
        <property type="protein sequence ID" value="RQG91222"/>
        <property type="gene ID" value="EA462_04320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030665">
        <property type="entry name" value="KaiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039117">
        <property type="entry name" value="KaiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="242"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="492" mass="53521" checksum="E4CBD40E14521C7E" modified="2019-02-13" version="1">MRTSLQTIETGVAGLDEILQGGLVTGRLYLVVGLPGTGKTLLGMEFLRTGLEADETVLFVHGEESQPEILANASSFGIDLSDAEFLDLGPDSDFFDDDHSYDLVDSRDVESEQFIADIRASIEEINPDRVLLDPISQLQYIEPSEYQFRKRLISFMRFLKGRGTTVIATKTPEGSRGDNEVRSLSDGIVELERGDGGRRIAVPKHRGIGQRDGTHGLEIRGDGFEVYPSLLPEGHHDEFGPELISSGIEELDALFGGGLERGTATFISGPTGVGKTTTGIQLLSEAARTGDTPVAYLFEESPKTFIHRSESIGIPVTQLQADGLLSVEPVEPLELSAEEFAQRVKRRIETTETKTVMIDGVDGYKISIQGDESELGRKLHGLIRYLKSMDVAVILLDATDQVTGMPSATSANISYIADNIVFLNYIETDGELRKGIGVLKKRAGTFEKTVREFAITSDGITVGKPLTDVVGILEGTPTESMTVADDVTYRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0Z2</accession>
    <name>A0A3N6N0Z2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc-ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91602">
        <property type="protein sequence ID" value="RQG91602"/>
        <property type="gene ID" value="EA462_06525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="SSF144206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="54" mass="6139" checksum="716F74ECA2B44F46" modified="2019-02-13" version="1">MGLFSKAGKTFEEAKQSYMSSKGATYVCRSCEERLTEEYDYCPHCGEDSVEKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4Z1</accession>
    <name>A0A3N6N4Z1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93272">
        <property type="protein sequence ID" value="RQG93272"/>
        <property type="gene ID" value="EA462_00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="449" mass="48634" checksum="A35058580E1F3B82" modified="2019-02-13" version="1">MERPTRRRLLTGVSAGSVLLSTKRWRADGGHSTDSDDGSSASASAESTLEVRISETNAPVAAGEYLEVTPVVENTGSTAVRTTVELIVGHDRERVSTVETTIDAGETREPMRMGFNTYPVPESDEFPVRVDADGATDERTVRVEGASTLANARPGADLSVEPGTSVLFEAGAVDPGDGQRTIWWLDGEQIGDTAVDTWQPAYYDERGAHFFRYAFDSPGTHEVTAAVLPDAEAGTYGARWTIDVTADGTRAPAIETSRPTDQVIEVARDDPADVEFELEATVPDGALDRVIWWLTQSDSILGVSDLEDRRDTARLSTVGCHTCTLVPWVVCRDGTVTEPDPSWQFERVDRRGTVEVTIHDTNDPVAAGDVLEVAAAVVNTGSTAETRELELVVGHDPTVVDARTVVVDPNETARVRLGFETYPTEKDERFPARVVTEDDADEVSVRVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NU88</accession>
    <name>A0A3N6NU88_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_16365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86710">
        <property type="protein sequence ID" value="RQG86710"/>
        <property type="gene ID" value="EA462_16365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="289" mass="30550" checksum="5196CC4896368D42" modified="2019-02-13" version="1">MLDLGQIAFAIINGLVFGSILALIAVGLSLIYGVLDVPNFAQGEFATLSGFIVVGLMGFGLGLVPSIIVAIVAAVVAGIALERLVIARFYGREEFLLLTFFATFGVTIISENAHQMIFGGFRQIQGPELGTISLVGSTYSLLNVLSGVFAIIMIIGLYIFTKYTYTGLAMRAVADDQTGTEILGINYGRIYMVTFALGGALTGISGILYGMSYTLSPTLGVLLTLFAFTIVVVGGIGSFQGAIIASFLVGLVESFASTFIGSQWRLFAVFFLLFVVLILRPQGIGGVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUG8</accession>
    <name>A0A3N6NUG8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86800">
        <property type="protein sequence ID" value="RQG86800"/>
        <property type="gene ID" value="EA462_16130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="386" mass="42372" checksum="4EA1F1BC2C19CCFE" modified="2019-02-13" version="1">MDAPGIEDYFEEHTAAFEEETGIHVEFETVGWGEAQDTLMSDITSRTGPDVQEIASTWIPEQYDANGWMDLESDEVVDHIPDTGMFEDGAMDVATFQDTLVGIPWFWGPRAWQQVDEEVEAGDVAGHPEDWDGLVDQAQAYDGDNHLFALMGSDYEPMRNFAMFLWQSGGQLLTDDNSEPAFHNEAGVQALQFYADLYAEYDVLDSETVEWAAADINGAFAGGQMASTIDALGTVGAYEEEDGQSLDDLSISAPPVGPDGDGGTFFGMELLGIHPWTDEPEAAAQWIEYLLRAEPNAEISSTVGFLPTNPDGFDTEYFEHDVYQTFNDDVFPVAQTYPQVLGWGEIEGELNRSVAEVIQNAVTGDLEEGDVQNALDDAAEVAHQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NW93</accession>
    <name>A0A3N6NW93_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88789">
        <property type="protein sequence ID" value="RQG88789"/>
        <property type="gene ID" value="EA462_10305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="237" mass="26083" checksum="C915699CACF0C23C" modified="2019-02-13" version="1">MYAVDLHAHTRFFHGHRQLGDRFDPLGVRLLARAAKRRGLEGVATTNHDYYTPLDPPADVELVPGIEITTDRGHVLAVGPDPPAETKPGTLTPAEAVELAHERDCAAIVAHPFRNSTIRELEEVPFDAIEVNGKHPRSRPLVEALAEGRNLPLVGGSDAHYPLEVGRAYTIVDADRLTPTAVVEAIRDGRVGARVAHSRFDRLLRRGYRTIHRRKRVIDALEEPTPGVGTPPGEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWL4</accession>
    <name>A0A3N6NWL4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88939">
        <property type="protein sequence ID" value="RQG88939"/>
        <property type="gene ID" value="EA462_11140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="165"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="262" mass="28540" checksum="BBD067324675DFA1" modified="2019-02-13" version="1">MGDGIGGSYRLDEIDRRIVYALMGDARNTSAPAIADEVSVSGATVRNRIAQLEEHGIIEGYHATVDFEHADGSLMNLFLCHAPFGDVEGVARKIGTIPGIINVRELMGGRMNLHVLAVGTDTTDLRRIGRELENIDVEIEDEFLLQNEHDFPYTPYGPADSRRLEPLADYISLTGGANIVEVTVYEDAPIAGRTLEEAAREKVLGEETLVVAIERDDAVITPHGETTIRPHDVVTVFSPDGAGESALKGFDETDGTRSRRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX06</accession>
    <name>A0A3N6NX06_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_12320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89149">
        <property type="protein sequence ID" value="RQG89149"/>
        <property type="gene ID" value="EA462_12320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="9">
        <location>
            <begin position="277"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="10">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="MCM" evidence="9">
        <location>
            <begin position="516"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="852"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="852"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG89149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="882" mass="98709" checksum="59578A03B3F1CA5F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYT3</accession>
    <name>A0A3N6NYT3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phoU</name>
        <name evidence="3" type="ORF">EA462_08465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90029">
        <property type="protein sequence ID" value="RQG90029"/>
        <property type="gene ID" value="EA462_08465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="120"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="223" mass="25441" checksum="3B7D255BFF006BFE" modified="2019-02-13" version="1">MARQSYQDKLAELREDILYMSEVVLERLRMGLDALEQKDDDLANEVITGDGEINRMYLDLEQDCIDLLALQQPVASDLRFIAASFKIITDLERIGDLAVNLGEYTLEAERDLFPDVDVQAMGEMTLEMVSEAMSAYEREDVDACRRLAVDDDDVDNFAERASSIVVRDLIERELDSPDEVELILQDVSRLLLTIRDLERVGDHAVNIAARTLYMVENDDELIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ22</accession>
    <name>A0A3N6NZ22_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90139">
        <property type="protein sequence ID" value="RQG90139"/>
        <property type="gene ID" value="EA462_09115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="128" mass="14201" checksum="BE056794BD04451E" modified="2019-02-13" version="1">MKYGVSMKPQTENPNDGETPSVASTDLFVAFSAERRQHALAYLAQKPAAIPLGDLAEYLTLVEGDPSYDRYERVLTDLYHNHVPKLVDAGIVTYERETELVALSVTRRVLSPYLQLAELETVSSASND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0C7</accession>
    <name>A0A3N6P0C7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87898">
        <property type="protein sequence ID" value="RQG87898"/>
        <property type="gene ID" value="EA462_13630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="222" mass="24368" checksum="C30C1DE52914D36B" modified="2019-02-13" version="1">MSLEDIQADLELEAKNTAVIVVDMENDFVAEGAPLETPMGRAFVDELNTFLTECRDAGSQIVYTTHVHRESGCDMGTMADIWVPIEQQAGLVDETEGVEIYDPISPEEDDILIKKHRYSGFYGTDLDIILRNSGIENVVITGVTTENCCAMTARAAQFRDYDVVFLADLTGTFDYPDQGYGERSAQEIHETVCTIMGTSVGTLATADDVLETFGRRAVASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1I9</accession>
    <name>A0A3N6P1I9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88945">
        <property type="protein sequence ID" value="RQG88945"/>
        <property type="gene ID" value="EA462_11170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="31"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="400" mass="42372" checksum="7B1CAF4918CE0721" modified="2019-02-13" version="1">MTEDGGVSDGAREHLAADTDTAVEGDSSLTVAVIGAGAVGTTAAYALARAGADVTLYDRGSVASGASGRAAGICYDAFADSLEATLAAESIERFRALSGEETFPFVECPYVWFAREGDDDRIDAVRRQVRRMQENGVVVLEVDGSALGERFPSLRTDDIAVAGIAGAAGYTDPARYTDCMAAAATGAGARLEAETDVAVRTTPPRVVLENGAGREFDAVLVAAGARTKRLLADAGVSIAMKPYRVQALIGSGDFEEPMWYDATDECYARPHLDGLLAGNGAEHREADPARYDRDADPEFAATLETRIRHRLPDVELGLERAWAGLCTATPDRDPLVGRLREGVYVATGFQGHGFMRAPAIGERIAREISGGSGIDAYDPTRFAGDEEFDVTEGTTLTFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1L0</accession>
    <name>A0A3N6P1L0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="8">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">trpE</name>
        <name evidence="12" type="ORF">EA462_05350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91399">
        <property type="protein sequence ID" value="RQG91399"/>
        <property type="gene ID" value="EA462_05350"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010116">
        <property type="entry name" value="Anthranilate_synth_I_arc_typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01820">
        <property type="entry name" value="TrpE-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="11">
        <location>
            <begin position="76"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="10">
        <location>
            <begin position="276"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG91399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="568" mass="61443" checksum="479858A8CDD037E9" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1N8</accession>
    <name>A0A3N6P1N8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89005">
        <property type="protein sequence ID" value="RQG89005"/>
        <property type="gene ID" value="EA462_11510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="188" mass="21520" checksum="A2BBC12BB2164379" modified="2019-02-13" version="1">MTRYHLFVLAAVLVAGLVLFGRHRWRTRERRGLERDLDSRLAEAIPAGTASHLDRSPTVRRLAVVETTGDEDDVSRTVYVPTVRVDLGMVDVPRTEFAFGYVADVLEAIHPVFEAREDRVRRYDVEFTFGPSGLIVDGECRRVSIPPELAERLLVDENYRAFDLWRTIERDDDEGRAVFWGDCTETPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1P9</accession>
    <name>A0A3N6P1P9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91449">
        <property type="protein sequence ID" value="RQG91449"/>
        <property type="gene ID" value="EA462_05645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="135" mass="15314" checksum="6238D408D90E5548" modified="2019-02-13" version="1">MRKCTTRVWFRRSHSCANGAERSSSALILKQMVPAFALKSAEWRRADGDWSAHSEDGRDEALERDNHECQRCGEDTDIEVHHLIPRSAGGPDKAENLVTLCSKCHSWVHAAGFSQLLEERSDLYEELREAVCDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1U1</accession>
    <name>A0A3N6P1U1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89075">
        <property type="protein sequence ID" value="RQG89075"/>
        <property type="gene ID" value="EA462_11905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="150" mass="16686" checksum="B0C44B18FBFA3306" modified="2019-02-13" version="1">MTETIPNEPIDVLLVEDNPGDARLTKEAFKATDSEIRFHVATDGVEAMKTIHTRQCNGSCTRPDIIFLDLNLPGLDGFDVLETLRTELEYPPPPIIVLSSSKTSEDVTRSYELDANAYVTKPESPDEFNTVAQAIEDFWIDAVRHPPVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3H3</accession>
    <name>A0A3N6P3H3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89835">
        <property type="protein sequence ID" value="RQG89835"/>
        <property type="gene ID" value="EA462_07400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="23"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="412" mass="43146" checksum="D19CE1E55503479F" modified="2019-02-13" version="1">MTRSDSEIDDHERTSAFRFEYEPPALRFGADSVDGLEDELERRGFERAMIVCGSTVGGSPDVIDPVKSGLGSRLATVFDETTPKKRLGTAFDGLERLHAEDVDVLISLGGGSSLDVAKVLSTLAASGRSRSDIGAEFSDRGTITVPDEGLIPIVAIPTTLAGADLSQVAGVTASPESGLVDEEIGGGISGPELMPTAAFYDPSLVATTPESILSRSVMNGFDKGVETVYANNATPVTDATASRGIGLLADGIRSYGRGDRGIGTFETLLEGTVLVQYGISRPGETTLSVVHSFGHGLTRTYDVQQGAAHAIVVPHVLEFLFDDDAVDARVTTLAAGLGVDDAADPAKAVLECVMDVRDALGLPTRLRDVDGPARAEFPAVAKAILADSFMANAPPGFDPDPEEIEGVLERAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P497</accession>
    <name>A0A3N6P497_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase</fullName>
            <shortName evidence="2">ADH synthase</shortName>
            <shortName evidence="2">ADHS</shortName>
            <shortName evidence="2">ADTH synthase</shortName>
            <ecNumber evidence="2">2.2.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroA'</name>
        <name evidence="3" type="ORF">EA462_09410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate</text>
            <dbReference type="Rhea" id="RHEA:25952"/>
            <dbReference type="ChEBI" id="CHEBI:58859"/>
            <dbReference type="ChEBI" id="CHEBI:58860"/>
            <dbReference type="ChEBI" id="CHEBI:58861"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.2.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.10" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90195">
        <property type="protein sequence ID" value="RQG90195"/>
        <property type="gene ID" value="EA462_09410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00960">
        <property type="entry name" value="ADH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010210">
        <property type="entry name" value="ADH_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01949">
        <property type="entry name" value="AroFGH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0704">Schiff base</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="25"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="DKFP binding" evidence="2">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="27640" checksum="4087565550B3747E" modified="2019-02-13" version="1">MTTTGTTARLDRIGTEGSYVIVPMDHGITMGAVQGLKEIESTIDGVTRGGADAVLTQKGIAPRVHENKNDKGYIVHLNASTTIGPDENDKRLTGTVEEAIRAGADAVSFHINVGSDHEPNQLTQLAEITETADRFGIPVLAMAYARGSGVDSEDPVALGHAVRLAEEIGADIVKTGYSGDADSFQHVVESTRLPVVIAGGSKGTDRETVEMVRGVMDAGGAGVSMGRSIFQHENPEAIARAVSGVVHADLETDEALEAAGLTLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4D9</accession>
    <name>A0A3N6P4D9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_00740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92789">
        <property type="protein sequence ID" value="RQG92789"/>
        <property type="gene ID" value="EA462_00740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="27"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG92789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="202" mass="21936" checksum="3975C3F193CCDDE1" modified="2019-02-13" version="1">MGSMEDLRVTECTRCPALVDSRSRIVNGTGPADADVLFVGEGPGAREDERGEPFVGRSGSVLDDQLRIVGLDRDAVRITNCVRCRPPDNRDPTTDELENCRGYLESEIDRLDPAVIITLGKVPSEHLLERSVAVTKEAGAIEEIRIDGTPRRLVVCVHPAATLYDRSQEETFAAAIERAADVAGVDGTESDQTRLDGFDRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4E3</accession>
    <name>A0A3N6P4E3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92799">
        <property type="protein sequence ID" value="RQG92799"/>
        <property type="gene ID" value="EA462_00790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="380" mass="41298" checksum="5BA7CD309892C693" modified="2019-02-13" version="1">MVTTLSPDRLAELQDEETEFALVDTRPEDSFEAWHVSGAIHFPFGPEENLDGRLEEFERAVGDADRVLTICAKGISSGNLATQLESATDAYEVQAVDGGMKGWSGVYDHVEVDAGDGLTIVQIQRRAKGCFGYLIGCPATGDAVVVDPTADVDEYEIAATRADLSIVGVIDTHVHADHISGGRDLAERLSVPYYLSERAIARGVEYEFTPLERNEVLAVGDRELKALETPGHTSEMISLLLDDRALVTADTLHVDSTGRTELEFSEDEGKEGARMLYEALHRTVLAEPEGVVVLPGHVTVTADGEFAHGRPGEAITTTIREARTGIELLDLDEDAFVDRMADAGEKPANYEEIIEYNRGTLELAPEDRVELELGPNNCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P5Z9</accession>
    <name>A0A3N6P5Z9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91125">
        <property type="protein sequence ID" value="RQG91125"/>
        <property type="gene ID" value="EA462_03775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="143" mass="15050" checksum="9A91E9E55389C7C0" modified="2019-02-13" version="1">MVSRENLVIVSSFVLLVLALAGIGIVDGATTVALGEYPLVMYLLFAGLTIVGPQLYLAATDDDVPPRTRVRFATIVWGLFALVMADVSRAEAVLGSGILGADLETLQHLAILAIGGGAFVALVCHEFVAGYRSQETDESQSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6G9</accession>
    <name>A0A3N6P6G9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_05275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91385">
        <property type="protein sequence ID" value="RQG91385"/>
        <property type="gene ID" value="EA462_05275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="428" mass="46289" checksum="11F9BFDC7C2B7301" modified="2019-02-13" version="1">MSDDSHDHQFATDSIHAGQDPDPTTGARAPPLYQTTSYAFDDTEHAAALFGLQEFGNIYSRIMNPTNAMLEERIATLEGGVGALATSSGMASFDLATFILADVGDNIVSSSSLYGGTYTYLTHTVSKRGIETKFVDTLDYDAYAEAIDDDTAFVHLETIGNPALVTPDIGRIADIAHEHDVPLFVDNTFATPYLCRPLEHGADLVWNSTTKWIHGAGSTVGGILVDGGSFPWDEGEYPELTEPNPAYHGINFHETFGEQAFAIAARTRGLRDLGNQQSPFDAWVTLQKLESLPLRMEKHCENAMAVAEYLEDHSSVSWVNYPGLESHETHDEASEYLEGGYGGMITFGLEGGYDAAETVCNEVDLMSLLANVGDAKSLIIHPASTTHQQLTEEEKLAGGVTDDLVRLSIGIEDVDDVIADLDQAISSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6I3</accession>
    <name>A0A3N6P6I3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine protein kinase PrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91415">
        <property type="protein sequence ID" value="RQG91415"/>
        <property type="gene ID" value="EA462_05435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013153">
        <property type="entry name" value="Prk_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010650">
        <property type="entry name" value="PrkA_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08298">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06798">
        <property type="entry name" value="PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00763">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA_PrkA" evidence="1">
        <location>
            <begin position="27"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="690" mass="80427" checksum="D2F2E4E00ABCA2E0" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6Y2</accession>
    <name>A0A3N6P6Y2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Complex I NDUFA9 subunit family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91655">
        <property type="protein sequence ID" value="RQG91655"/>
        <property type="gene ID" value="EA462_06820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="294" mass="31092" checksum="85DC58C68A11D566" modified="2019-02-13" version="1">MKVLVAGGTGFIGTNLCAELVERGHDVTALSRTPDDDVRDGVELAVGDVTAYDSIVDTVADHDKVVNLVALSPLYQAPDNAQERVHLGGTENLVRAAEAGDVDRLVQISALGADPNSEIDHIRAKGRAERVVRESSLDWTIFRPSVVFGDGAEFLEFTTQVTTPYVTGLPGGGRTRFQPIWVGDLVTVLAGALESDDHIGAVYEVAGPQVVTLADATELAYEAEDKPVSILPVPMALAKIGLAAVGPVPFVPFGPDQARSLEIDNTVGENDVSAFGLDEDDLTTLRTYLGADSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P725</accession>
    <name>A0A3N6P725_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Archease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_05625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91715">
        <property type="protein sequence ID" value="RQG91715"/>
        <property type="gene ID" value="EA462_05625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="PTHR12682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="144" mass="15894" checksum="80D03D0142EDC353" modified="2019-02-13" version="1">MSYELRDHTADIAVAATGGSLEAVFAATADGLTAASSEEDTETHDGERFSISVTAENPEALLFDYLDQVIYLRDVRVELPVDHRVDRIETAAGDRNDQRWVLEASARGIPLSKIVARDVKAVTYSEMSLEQVEDGWEAYVVFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9M5</accession>
    <name>A0A3N6P9M5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92955">
        <property type="protein sequence ID" value="RQG92955"/>
        <property type="gene ID" value="EA462_01690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="15043" checksum="54CA5D5E3EFBCE00" modified="2019-02-13" version="1">MISRALVPMDGSAMSEQALTYALEAYPDAEITVLHVVGEPSPLWGEATGLALADDLEETVQDHAQSTFDRARELVANADGDADVETVVELGHPVRAILTHADDYETIVVGAHGGSISDRLFVGNVAEKIVRRSPVPVVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA76</accession>
    <name>A0A3N6PA76_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacterio-opsin activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_03420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93255">
        <property type="protein sequence ID" value="RQG93255"/>
        <property type="gene ID" value="EA462_03420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="215" mass="23131" checksum="35651A9FEDFD5D6E" modified="2019-02-13" version="1">MKSMHVSLAHDAETLSPIHAAICDSSDLEREVILGGQAVDGVETITSFVTGEARAYEPALEGLDGVHEYDVTPADDGFFLYLRRDLEAEGLSMLTALAQETVVVVPPIEIRADRTIRLTIVGHPTDLTTVLEELSAGVTADVLWVSDSVTVTDSPVSDRQLEALEVARNVGFYEIPRRNGIEAVATELDCAVSTASELIRRGEAAVVGRTLDTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA99</accession>
    <name>A0A3N6PA99_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin molybdenumtransferase MoeA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_01065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93285">
        <property type="protein sequence ID" value="RQG93285"/>
        <property type="gene ID" value="EA462_01065"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="4">
        <location>
            <begin position="209"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="451" mass="47585" checksum="E3DBFCBC9B31C625" modified="2019-02-13" version="1">MKGADSERTESGFKVRTSVDEARRTLREAILAGGGGDGDVEDDRAGSPLTGTERIDLERADGRVLASPVASARNVPHYRRAAMDGYAVQASDTFGASERSPEVLRITEGIGGDASVDPGTAARVHTGSALPDGADAVVKIERVTELPSAGELEVDDAVAEGENVAPIGEDVEEDQHLYDEGHRLRPSDLGLLRSTGYASVSVAAQPTVGVVPTGEELVTNDPEPGEVIETNGLTVSRLAERWGARVTCRDVVTDDPDSLRVAIQRDLTTDVVVTTGGSSVGKRDLLPEVIDELGEVLVHGVGLKPGHPICLGLVEETPVLALPGYPVACIVNAVQFLRPALAWLEGTTPKPHPTTRATLERKIPSEPGSRTFARVQLQERNDERGAREPDDKRGATETDDEPAVTAVPTRASGSGILSSVALADGWVVVDEGREGIPAGETVAVRNWEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHR6</accession>
    <name>A0A3N6LHR6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86155">
        <property type="protein sequence ID" value="RQG86155"/>
        <property type="gene ID" value="EA462_16925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="195" mass="21055" checksum="0590B628A1BD8EBB" modified="2019-02-13" version="1">MADVHVVALCGSLRGDSVTRTALEQTLEAAADLGANTELIDLRDYDLPVFDADRDREDAGDAERLADRMRRADAIVLGSPMYHGSYSSPLKTALDYCGFDEFEDTTVGLLAVSGGAFPVTALEHMRSVCRALNAWVIPHEAAVSNSNSVLEDGEFADSTLEKRIRTLGQRAVQYATIEPDPDSFESDQNVGATGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHR9</accession>
    <name>A0A3N6LHR9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86744">
        <property type="protein sequence ID" value="RQG86744"/>
        <property type="gene ID" value="EA462_16550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="63" mass="7138" checksum="15850451B7DAFA6D" modified="2019-02-13" version="1">MESKDWSHGVSRGWGLTTIPAKRIYRADRQSFGGSITAADRRDPQPVNRSWQAVGSFGWKMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHY6</accession>
    <name>A0A3N6LHY6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86679">
        <property type="protein sequence ID" value="RQG86679"/>
        <property type="gene ID" value="EA462_16180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="171" mass="19709" checksum="7C1EBB75499D3664" modified="2019-02-13" version="1">MADEARRDGPPPFDSPFENEDTKQRVYGAVLHAREPMTAAEIAERADCSEESARTHLSFYADLGIVIHHEGRPARYERNDDYFEWRRVNELAREHAVEELQARVSEFTERIERYRDEYGADSPADVDVLEFDATQVDDVYVDLGDWATAIEERRLHERARQKATGSTAPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI18</accession>
    <name>A0A3N6LI18_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86719">
        <property type="protein sequence ID" value="RQG86719"/>
        <property type="gene ID" value="EA462_16415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="272" mass="29853" checksum="80922E9EE09EE057" modified="2019-02-13" version="1">MSSKTQTASGLDQFSSWLQGSSRALGLVSVLLLLAVWQATAIYVNNPLLLPDIPAVSERLWEMFLVDRSVYPHIWASLYRVAVGFIAAVLIGVPLGLLMGSSSTVEYLLEPYISTLYPVPRIAFYPLLLVILGFGHSSKIAIIFVEALIPIILGAYYGVGGVQQRYLWSARNFGASQLQTFREVILPGSLPYIFSGIRMAMPIAIIVTVVTEMISASQGIGYLIIYSQASFEPETVFAAVIVISAIGVLFDRLLAVIRERLLFWAKDVSMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI79</accession>
    <name>A0A3N6LI79_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_15325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87014">
        <property type="protein sequence ID" value="RQG87014"/>
        <property type="gene ID" value="EA462_15325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="573" mass="61162" checksum="23A8F4D22B2A23F5" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIA2</accession>
    <name>A0A3N6LIA2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_15570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87054">
        <property type="protein sequence ID" value="RQG87054"/>
        <property type="gene ID" value="EA462_15570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="342" mass="37212" checksum="D1E855B66B331199" modified="2019-02-13" version="1">MAAVELEGLTKHYGGVRANDSISFAVERGEIFGYLGPNGAGKTTTIRMLLGLISPTDGSARVLGADITDERALIEAKRRIGYLPDDPQFDESATGREILELHAGIKGDERSEKLLDLFDPPLERPIREYSHGNVRKLGLVTAFMHDPELVILDEPTGGLDPLMKQRFAEFVRGERDRGRTLFFSSHILGEVRRLCDRVGIIRSGRVVTVEPIDALVDRSGKVVRLVTADPIPRATFDRDLEGVHDLEVGAGNRTHDPGGGRTATTDAQSDPTSGPDDSGNKSIGAVGESDRPETFREYTFTFTGPVDELLAVLSGTELVDLTIEEAPLESVLLRFYGDGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIM2</accession>
    <name>A0A3N6LIM2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(2Fe-2S) ferredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87079">
        <property type="protein sequence ID" value="RQG87079"/>
        <property type="gene ID" value="EA462_15720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="119" mass="12863" checksum="B082FDA760F67A54" modified="2019-02-13" version="1">MKRRTDRQRDRVGAHVLVCTNGRDSEYACCRDAGSDAVVQAVKTWLRDRDAFWSPIAVTTTGCLGLCSEDGTAIAIQPRNEWYADVTPDDVPALLAREFGTDAGSIDGRAVDAVDSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIS7</accession>
    <name>A0A3N6LIS7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87866">
        <property type="protein sequence ID" value="RQG87866"/>
        <property type="gene ID" value="EA462_13465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="59"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="365" mass="40449" checksum="8DE44F4D1FF61FE9" modified="2019-02-13" version="1">MEGKRDPTAARGGRTGSATPSIGLSLFYAHPHQYLCEFGFVIQSMSGQGTRQLVDFGGHVHPTDPEAFAYYHDFIEENDGSPVCRDAKAVQRRYANSAVDYTVLSQPYFMGHGDADETATANDELLRIVEEFDEFFGLAAIPTAAGGEAAANELERSLEAGYHGGAIETKSDGIELIDDELESVFRVAEKHDAPLLVHPKLHDSLHEDVLDDTWRLNAIFGREVALCESICKVIHEGVLDRHPKLNLVYHHTGGNLAAMLDRVRLQLDDDLWPGLDDVVSYREFEETFETRIYVDTSGYDGSPSVLRRTLETLPSSHVLFGTDFPYETRTPETFEALITSVTETCSESDSKRILGANAFELLTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ50</accession>
    <name>A0A3N6LJ50_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87881">
        <property type="protein sequence ID" value="RQG87881"/>
        <property type="gene ID" value="EA462_13540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="431"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="518" mass="57285" checksum="727FD7C20FCB0141" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ70</accession>
    <name>A0A3N6LJ70_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87921">
        <property type="protein sequence ID" value="RQG87921"/>
        <property type="gene ID" value="EA462_13745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="10"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="320" mass="34031" checksum="3E9E6282528FCF38" modified="2019-02-13" version="1">MKAVRYHEQGEPGVLRVDDVPKPTPQNEEVLVEVHAASVNPIDTKFRNGFYSPPELPMTTGSDFSGVVVEVGDGVDDFEPGDRIIGDGLNKRSGYQGSFSEYAVAPLESIAPIPDDVSFDDAAALGHAGLTAWCGIVAYGDVTIGDTCLVHGGSGGVGHIAVQLARQSGAKVIATAGTDHGLEKLEQLGVDHAISYERDDLQEAIEEAGAPDVILDPLLGEYLELDIEVAAPNATIVAIEGREVTFTNAPTARRKDLCLYQVGAASLPDVSGALERLATLLGRELIEVVINQKFDLEEAAEAQRFTIEANDFGKVLVQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKQ7</accession>
    <name>A0A3N6LKQ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89258">
        <property type="protein sequence ID" value="RQG89258"/>
        <property type="gene ID" value="EA462_12910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="200" mass="22497" checksum="AFB0E561B1300429" modified="2019-02-13" version="1">MGGIELRNGTLVVEREPNQLDELAIGFSETLGQFDIKHVYIAGYVSILAGRARSTEDVDVLIEQIGEGTADELAETLDEKGFWGPAMPLSSMYEMLDNGDNIWVAPEDQVTPHLEVKFARDEFDRASLENAITARIGGEAISIGPLELQIAYKLHLRAQKDIEDAVHLYTLFEESLSVFRLEEWVTRLDVEAEYERLKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLA5</accession>
    <name>A0A3N6LLA5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein subunit beta/FixA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87860">
        <property type="protein sequence ID" value="RQG87860"/>
        <property type="gene ID" value="EA462_13430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="28488" checksum="16988F2F98676F70" modified="2019-02-13" version="1">MKVLVTAKEVATVENEFEIEEMAIADRYLGADLNEWDDYAVEEAVQLKEADIAAEVVTVTIGPDDCEQTIRQALAKGADRAIRVWDDTLEEATLLDVGAKTELLAAVVEDEEPDLVLTGVQSDDDSFGATGVSLAEAVDYEWAAVVNHLEHDLKDGGASIRRELEGGVEELTDVSLPAVLTIQTGINEPRYASLRGIRQAQRKELSVQDLAALGVDESAVDSALELTAMYEPESQSDVMLWEGSPEETAGELAELLREKGVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM45</accession>
    <name>A0A3N6LM45_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative HTH-type transcriptional regulatory protein EA462_09135</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_09135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90143">
        <property type="protein sequence ID" value="RQG90143"/>
        <property type="gene ID" value="EA462_09135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00584">
        <property type="entry name" value="HTH_type_cro_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020886">
        <property type="entry name" value="Arc_TR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="323" mass="35835" checksum="2BB08FA99B842A59" modified="2019-02-13" version="1">MSRSALVGNVTAMLEDAGFVVSDRCAIRPKSFDIAARRDEDLILVKILGNIDAFNEATGHEMRRLGTYLQATPLVIGLRSRDEDLKPDVVYFRHGVPVFSPDTAYNLFIEGVPPLIYAAPGGLYVNIDGDLLADEREDREWSLGQLATELGVSRRTVSKYEDGMNASVEVAMALQELFEAPLTSPVDVLDGAEDVHETQATPDDPEADPDDEQVVTVLTRAGYRVHPTIRSPFKAVSRDEEDADEEVVLTGHSEFTKTAEKRARIMSSISHVTRTHSVYVVDRAKRESVDGTALVERDELEELHDADDLRAVIRERAEREEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM69</accession>
    <name>A0A3N6LM69_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_17070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86181">
        <property type="protein sequence ID" value="RQG86181"/>
        <property type="gene ID" value="EA462_17070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="91"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG86181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="200" mass="22305" checksum="A0DAB22E90B72A92" modified="2019-02-13" version="1">MTDHELPPLPYDYDALEPSISEQVVTWHHDTHHQGYVNGLNSAEETLAENRESGEFGSTPGALGNVTHNGCGHYLHTLFWENMAPNGGGEPDGDLADRIEEDFGSYEGWKGEFEAAAGAAGGWALLVYDPVAKQLRNVAVDKHDQGALWGSHPILALDVWEHSYYYDYGPDRGSFIDGFFDVVNWDSVDEEYQKCLDHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM94</accession>
    <name>A0A3N6LM94_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_08920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90108">
        <property type="protein sequence ID" value="RQG90108"/>
        <property type="gene ID" value="EA462_08920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="8">
        <location>
            <begin position="81"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="7">
        <location>
            <begin position="460"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG90108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="909" mass="103051" checksum="A325E4A6D217ECB1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LME3</accession>
    <name>A0A3N6LME3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BsuPI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90253">
        <property type="protein sequence ID" value="RQG90253"/>
        <property type="gene ID" value="EA462_09745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020481">
        <property type="entry name" value="Intracell_prot_inh_BsuPI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038144">
        <property type="entry name" value="IPI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12690">
        <property type="entry name" value="BsuPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BsuPI" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="8869" checksum="C169F0C7FD5E0780" modified="2019-02-13" version="1">MTLEGTLEPTVSIGGGGTPAVEFAFSDGRAFAQVLGSERLDTDDVATYDGSWTDAQPGQYTAVAELLARETSCEARAEITVPQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMJ2</accession>
    <name>A0A3N6LMJ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90248">
        <property type="protein sequence ID" value="RQG90248"/>
        <property type="gene ID" value="EA462_09705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="482" mass="51989" checksum="0C9792C949AB4EF9" modified="2019-02-13" version="1">MSTGVTISSISDYAILGCGSVGYAVTEELVEQGKDVRIVDRDESRVESLRDQDLDARSADIREPATADLVADRDVVLILASDVESNKQAVEHIRANNENQFVVARASDPVSGDELEELGADIVINPSSVIAESALRALESGELEYNAGKLAQLLEETSNELAIVTQDSPDPDSIASAAALQAIADHLGVESDIIYLGDVGHQENRAFVNLLGIDLIQWDELEDHSVYDTVALVDHATSEEMDLTVDVIIDHNEPDADYEPEFVDIRPNVSSTSTIMTKYIQEFDMNVSEEVATALLYGIRAETLDFKRDTTPADLTAAAYLYPFANHDTLEQVESPSMSPETLDVLAEAITNRDVQGSHLVSNAGLVRDREALTQAASHLLNLEGVTTTAVFGIAEETIFLAGRSKDIRINIGKVLDDAYGEMGETAGHSTQASAEIPLGIFTGIEISEDTRDTLLELTEEAVKRTLFDAMGVDGSEGSNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMJ6</accession>
    <name>A0A3N6LMJ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90258">
        <property type="protein sequence ID" value="RQG90258"/>
        <property type="gene ID" value="EA462_09770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="232" mass="25937" checksum="07FEB53B80031A5A" modified="2019-02-13" version="1">MATEDETRIERRIRGQFDRLSWVQKSLLTGAVLTLLWMYFVPGDLDERIVVDGILLIGGPLALGLTHGRHIGWNINRVAVRNAVLLSLFVLPFYLVGSTLPTIREFYPMWYTSAALGEFVPHAAQLFLLALATETYYRGLLCVGIKEIGFKAVFISPIVYMIHHASKPPIEFLLSGPTDVLFGAVDYKSNSILPSVIAHGAGLVLLDWLILHDPLFDPTPVLQYLEWVPIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMM4</accession>
    <name>A0A3N6LMM4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90308">
        <property type="protein sequence ID" value="RQG90308"/>
        <property type="gene ID" value="EA462_10045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="2">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="13113" checksum="322757617FA6E342" modified="2019-02-13" version="1">MTMEATRYDDGSISYPGHPRGPGETQPVETIDLSEYTATVVTWTVSTATPPGVREPNTLAIVEFDVDGQPVRALGQVTTQDVETGDVVRPVHVDELREPGAGIREPNSQDWDGYRFEPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMN7</accession>
    <name>A0A3N6LMN7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90328">
        <property type="protein sequence ID" value="RQG90328"/>
        <property type="gene ID" value="EA462_10160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="149" mass="15757" checksum="8BC2ABAB6A07FA22" modified="2019-02-13" version="1">MSQESTTETEGESESASLPGGLDYERISDNVDVGELVQGTQWEDEIDEDEPLGQAIGGLIGSSVGRLIGERIGQTVGEMLMDELFDPGSADGDSDADDESAADESEESGEDESQEADAQDEDESQEADAQDEDESQEADAQDGEEGEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNB4</accession>
    <name>A0A3N6LNB4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_15750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87085">
        <property type="protein sequence ID" value="RQG87085"/>
        <property type="gene ID" value="EA462_15750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="127" mass="13729" checksum="8FF4F7D2656CA312" modified="2019-02-13" version="1">MIEGALDVLATRYAYALMFVLMGIGMYMMIANENLVKKLIGVNLFQTAIFLFFVAVAYVEGGQAPIVPDDPVPGELAMASPLPHVIVLTAIVVGIALTAVGLALIVRIYAEYGTLREDTLREVRADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP73</accession>
    <name>A0A3N6LP73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91223">
        <property type="protein sequence ID" value="RQG91223"/>
        <property type="gene ID" value="EA462_04325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="146"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="344" mass="37341" checksum="ED8FBA041F955EB4" modified="2019-02-13" version="1">MTTTSVGRTGPSTIQLLVDDDANSDALSELLEERYSVIGADAESDGDLYLVDDSSFSTHRDRIEDLKSGSGPSFTPVVLVRRKGTRVNLSLPGESSESGPPLVDEVIDAPVRKTVLFRRLSNLLVRRQQFRRLEDQNDRLERFASVVSHDLRNPLQVASGRLELLEASVPESDREHLEIARESLDRMDDLIDDVLGLARAGKTIEETTAVVISDAARRAWTVVESDAADLNVPERSAAIVADADRLSSVFENLFRNAIEHGRNDVAIEVGVTDTGFYVADDGPGIPSEEREHVLERGYTTSDDGTGIGLDIVTSVADAHGWTVSVGESDGGGARFDVSGVDRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP87</accession>
    <name>A0A3N6LP87_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetyl-D-mannosamine dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.336</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-ManNAc 6-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_04430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate</text>
            <dbReference type="Rhea" id="RHEA:25780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:68623"/>
            <dbReference type="ChEBI" id="CHEBI:70731"/>
            <dbReference type="EC" id="1.1.1.336"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91243">
        <property type="protein sequence ID" value="RQG91243"/>
        <property type="gene ID" value="EA462_04430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="9">
        <location>
            <begin position="342"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG91243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="488" mass="51161" checksum="E625DFEB183F001E" modified="2019-02-13" version="1">MVDGDGLYGSSRSDEQQRALLTSGRVPVAVYGLGKMGLPLAGVYAETTGNVTGVDIDPSVVGTVTNGESHVVGEPGLEALIADQVAAGRLEATTDGTAAAERARIHVVIVPTLLDDRQKPDLSTVDSVADDIAAGLSPGDLVIAESTLPPGTCRDVLRPHLAGKSGLESDAFGLAFCPERTSSGTALRDVRGQYPKVVGGVDAESGRAAAIVYDELSSNDVHLVSDATTAEAVKVFEGIYRDVNIALANELGRLADELEISVREAIETANDLPMCQIHDPGPGVGGHCIPYYPHFLLSRMTEPMELTRTARTVNDGMPTVTADRLEEELSSVGTSIAEASVVVLGLTYRAGVEETRASPAIDLVETLEDRGAAVAGIDPLVDPASCGARPVEIDRLEEEHFDAAVIVTPHEEFDRIPWTALESMIVVDTRDAMDLSGTDHRVYTLAGSADGRRPRAGASGDAVDRPDGEPGSEHGTASVRRTDGGNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPJ9</accession>
    <name>A0A3N6LPJ9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl1</name>
        <name evidence="8" type="ORF">EA462_05400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds directly to 23S rRNA. Probably involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91408">
        <property type="protein sequence ID" value="RQG91408"/>
        <property type="gene ID" value="EA462_05400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_A">
        <property type="entry name" value="Ribosomal_L1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023669">
        <property type="entry name" value="Ribosomal_L1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="210" mass="22860" checksum="2E4A362CB252F375" modified="2019-02-13" version="1">MADSDIETAVARALEDSPDRNFTETVDLAINLRDLDLNEPSNRVDESVVLPGGTGQDTRIVVIAEGETGVRAEEAADDVLSESDVADLDDDEAKDMADETDFFIAEEAMMQDIARHLGTILGPRGKMPDPLSPDDDVVETVNRLKSTVQIRSGDRRTFHTLVGAEDMNAEDIADNIDVILRRLHADLEKGPQNIDGVFVKTTMGPSVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPN4</accession>
    <name>A0A3N6LPN4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YccF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88844">
        <property type="protein sequence ID" value="RQG88844"/>
        <property type="gene ID" value="EA462_10610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="245" mass="27211" checksum="68B74DB9CB86C926" modified="2019-02-13" version="1">MKSENARWLWRHPHEDGLGGRIMGSISDIVTNGACPSCGLFAIVQGNDAYVCQLCGEQYQRDDLNVDESRTLSDVDSERVYDIEREDLSILRTTSVGDKHWEDAEVYAKTGPCPECGAWALNPGLGGATCDKCHEDVWKEAMDIDPRRQPVDIKGEVYSGGLDGVLRGSIVEKAIMWVLEIREEIKADSPDRELTPTEKYKKNLANLCFILGIMFCITIIGIPFGVLFFVLAAIVTPNLEENPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPS8</accession>
    <name>A0A3N6LPS8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="1">4.1.2.14</ecNumber>
            <ecNumber evidence="1">4.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eda</name>
        <name evidence="1" type="ORF">EA462_10950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="1"/>
    <dbReference type="EC" id="4.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88904">
        <property type="protein sequence ID" value="RQG88904"/>
        <property type="gene ID" value="EA462_10950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="217" mass="21994" checksum="50F976061780D0BD" modified="2019-02-13" version="1">MSQKRAVEDRIVESGVLAVLRGVDEDSIVPVARAIHEAGVGALEVTADGTRAAEKIAAVDRELEGTETVVGAGTVLDASSAESVIDAGASFVVSPHVDVDVVRTCNRHGVFVAPGVLTPTEAVTAMEAGADVLKMFPAKTVGPGHIGALQGPLGGVDIIPTGGVSRENVAEYFDAGALAVGAGGALVDYDAVSEGDMDQVRESAAAFVETVEDARSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPW5</accession>
    <name>A0A3N6LPW5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Photosystem reaction center subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90247">
        <property type="protein sequence ID" value="RQG90247"/>
        <property type="gene ID" value="EA462_09700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="97" mass="10736" checksum="34EF43376BC16A72" modified="2019-02-13" version="1">MDDTPQEITSLVGREIYSNNGVFVGEVEDIQLHLNGEAVTGLALGNLNAELFAEEARTEQGIIVPYRWVRAVGDVILVNDVVERVRDPDEEQDEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ47</accession>
    <name>A0A3N6LQ47_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">otsB</name>
        <name evidence="6" type="ORF">EA462_04625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91698">
        <property type="protein sequence ID" value="RQG91698"/>
        <property type="gene ID" value="EA462_04625"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="PTHR43768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="300" mass="32005" checksum="B4073AF5A3AEDBAA" modified="2019-02-13" version="1">MSETPPSRLEEHLPQIRRTLAGGSGLLVCLDFDGTLAPIVDDPEEATPLRENEAAVDRLSSHPAVSTAIVSGRGLPDVRDRVGGLDAYAGNHGLEFVRNGSVAVHPVARKRAVLVDQVCSALETVLEPVPSSRIENKRLTGTVHTRTVPAPLRPLVRRLTKSIVDRIGGDQLEVSSGRRVLEIGPSIPWGKGNAVELLSAELPRDTVAVYVGDDVTDESAFNTVEPNGVGVRVGGDRPSAASYRVTSPADVAAFLTWLESVGLEELDRSPGLVPTEPERPVERTTASDRRLGLSSETADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ82</accession>
    <name>A0A3N6LQ82_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89094">
        <property type="protein sequence ID" value="RQG89094"/>
        <property type="gene ID" value="EA462_12025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="86" mass="8883" checksum="E0D9BD6EFA61A27A" modified="2019-02-13" version="1">MAGLIDTIKLAGVLILAIPAALAGLELLLVRGETTTGGILLGLAVALVVVQRRLTMPTDIPELVAKRVGSTVASDPDPDSDPEQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ92</accession>
    <name>A0A3N6LQ92_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89104">
        <property type="protein sequence ID" value="RQG89104"/>
        <property type="gene ID" value="EA462_12080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="75" mass="7907" checksum="E54B873A192620F0" modified="2019-02-13" version="1">MADDHERSTDRVLLVIVLAVAVLVPVAFASLEVSPTRITAGTVVVASLLAVGSVVLPALLFSRWETASRHAGKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS04</accession>
    <name>A0A3N6LS04_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91267">
        <property type="protein sequence ID" value="RQG91267"/>
        <property type="gene ID" value="EA462_04560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="86" mass="9583" checksum="633B2DAFED58806B" modified="2019-02-13" version="1">MSATDQDPDIASDGDCCSSISELSPSAKLVYKVLEYEGVMTQEEIATESRLCARTVRYALRKLEESALVTSRVSLEDARKSKYWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSF1</accession>
    <name>A0A3N6LSF1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Halocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90204">
        <property type="protein sequence ID" value="RQG90204"/>
        <property type="gene ID" value="EA462_09455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="1">
        <location>
            <begin position="46"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="145" mass="15563" checksum="42D65942D2626403" modified="2019-02-13" version="1">MHRRVYLAAVGTAASSGIAGCTSLLSVLDGEPCSGDGCDIGMTRNEFVPDVYEVSVGDTVVWKNTSGADHTVTAFERTLPDGAEYFATGGYEDQATAVEAWHRSRGGRLGTRETYEHTFELPGEYGYFCEPHIKGGMDGTVIVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSG7</accession>
    <name>A0A3N6LSG7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92878">
        <property type="protein sequence ID" value="RQG92878"/>
        <property type="gene ID" value="EA462_01245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="317" mass="34204" checksum="B40B9F3A9858CC36" modified="2019-02-13" version="1">MSDLVTFGETMLRLSPPGSERLETTSEFEVCAGGAESNVAIAANRLGTPSTWLSKVPETPLGQHVVGSLRRHGIETDVVWSHRGRQGTYYMERAGDPRGSQVIYDRENTAFATAEAREFDIDRIQNARVFFTTGITPALSSTLRETTASMLKAARNGGTTTAFDFNYRGKLWEPEQAEETLTKLFPGIDVLVIAARDARTVLGFEGDPRQLAHKLGSQYEFQTVVVTRGSDGAVGWHDSVVHEQDAYDTDTVSEIGTGDAFTGAFIASRLDGDDVPTALENAAAAAALKRTIPGDVALITDEEVEAVVSEGGDDLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSK7</accession>
    <name>A0A3N6LSK7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flagella assembly protein j</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_09915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90284">
        <property type="protein sequence ID" value="RQG90284"/>
        <property type="gene ID" value="EA462_09915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="670"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="166"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="475"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG90284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="688" mass="76195" checksum="E1DC4FFE0B150E37" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSN1</accession>
    <name>A0A3N6LSN1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YigZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92963">
        <property type="protein sequence ID" value="RQG92963"/>
        <property type="gene ID" value="EA462_01745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="144"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="202" mass="21795" checksum="A8801CAA740F62A3" modified="2019-02-13" version="1">MSRSYRTLEEPATAEFVVRGSEFFGHARPVDSVDAAEEFVETVATEYADATHNVPAYRVRADADGDLLREYSSDDGEPSGSAGKPALNVLTRQDLENCAVVVTRYYGGTNLGVGGLVRAYSRAVKDAVEAAGIVERRPHETVSVTVAYDDSGTVRSVLESEGYEFDGEYQADVSFTVRVPIAESASLRDRIRSATSGRADLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSN6</accession>
    <name>A0A3N6LSN6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4330 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91537">
        <property type="protein sequence ID" value="RQG91537"/>
        <property type="gene ID" value="EA462_06140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025480">
        <property type="entry name" value="DUF4330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14221">
        <property type="entry name" value="DUF4330"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="306" mass="32057" checksum="B3CD238FE58C6A51" modified="2019-02-13" version="1">MILMIDDDGNLLGVVNVIDAIAIVLVVSIIVAGIAVVSGGDGPGTNLGATGALAVGLLLVVLLAGVAVVSGNGSEFETRYATVDLGEQPAYVVDRLEAGDVARLEDADEEITVTDVHATPVADRPLVTIQTELDDVVLENDRGRTTERFAGVPLKLGRELRLDFGAYAISGTVTDVGVDPTLPIDATTTTAELEARDVSPAVAEGLEVGLTETVRGETIATLEAVDREPATVVLESDDGTVHEREHPRHEDVTLSVTLQTVESETGLTFRDERIGIGTTIELALETITVEGEITRIDDGPASDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT28</accession>
    <name>A0A3N6LT28_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93168">
        <property type="protein sequence ID" value="RQG93168"/>
        <property type="gene ID" value="EA462_02900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="82" mass="8814" checksum="64D8AF0483E2280C" modified="2019-02-13" version="1">MYEKRIGRPERDPFDALVDVLAAVDRYDLLLGIVPIAFAVALVAASLLGVSVTQAMIVPAIVGVFTIVDACYRNPPIDQGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVF0</accession>
    <name>A0A3N6LVF0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91664">
        <property type="protein sequence ID" value="RQG91664"/>
        <property type="gene ID" value="EA462_06875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="156" mass="17041" checksum="335E5BB873144835" modified="2019-02-13" version="1">MDDCTFCRIAAGTEPASVLFEDERTIAFLDTQPAVTGHSLVVPREHEVELLTAESSTTEAVFRTVRTVASALETAFKPDGFSVFHSTDNLVGTVEHAHVHLVPRYETDDVSLSRHGFDDEEAATVTGSKRLENGRRVSDTAGYTVPEEQVVSYGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LW21</accession>
    <name>A0A3N6LW21_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">cas1</name>
        <name evidence="9" type="ORF">EA462_02000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93007">
        <property type="protein sequence ID" value="RQG93007"/>
        <property type="gene ID" value="EA462_02000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG93007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="331" mass="37899" checksum="3F43546CEB0816A6" modified="2019-02-13" version="1">MKASEGMYDEAVLFVTRQGSQVQVDGGRIVVWDVDGDEGRLASRPIEKVDTINVFGGVNFSTPFVAKANEHGIVLNYFTQHGKYRGSFVPEKNTIAEVRRAQYALSDDAELEIAKAMISGKIRNARTLLSRKGVHGTEVLKDLGVRTEKATSKDDLRGTEGEAAERYFARLDETLTDGWTFETRSKRPPEDHINSLLSLTYVFMKNEVLAALRQYNLDPFLGVLHADRHGRPSLALDLQEEFRPIFCDAFVTRLVNRGAITHDDFRTDNRLRDDAFDTYLSKFDDYMQEEFTHPYFEYTVSRRKAIRQQAILLRKVITDELDDYHPLTFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0I3</accession>
    <name>A0A3N6M0I3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88064">
        <property type="protein sequence ID" value="RQG88064"/>
        <property type="gene ID" value="EA462_14540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="414" mass="45219" checksum="0B770388401E9321" modified="2019-02-13" version="1">MIESEISRDRMQRRLDRLWEIGKTDRGGVTRLAYSEEENDAFEYVLEEISAIDSMAVEEDSIGNVFATTAPEASESLYLGSHLDSVFNGGRLDGTLGVVAALEAIEAVEASDEEPEIPPTLVLFRAEESARFGQAMIGSRGALGLLTTEDFSVVDQSNVPLWRAMQEAGFQPENLSEPTLDLNRIAGFLELHIEQGRVLDETSTNVGVVSSIRAPVRYRFEVLGDYDHSGATPMSMRRDAIAGAAEMITAVEEIGIEFDQDGDIVTTVGDITVSEGAINKVCGELSFPVDVRSNDRQFRDRIEERIVSSLEAIAEDRDLVLNTECINQTDPVELDEDMMEHLLETAESIGTSYRRLPSGGGHDAMNVQRLNIPTGMLFVPSVDGVSHNPAEETSEDAIEDAATVFARSIVDGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1C1</accession>
    <name>A0A3N6M1C1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PGF-CTERM sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EA462_10815</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
            <location evidence="2">S-layer</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the halobacterial S-layer protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88881">
        <property type="protein sequence ID" value="RQG88881"/>
        <property type="gene ID" value="EA462_10815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030115">
        <property type="term" value="C:S-layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026371">
        <property type="entry name" value="PGF_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026452">
        <property type="entry name" value="Surf_glycop_sig_pep"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04207">
        <property type="entry name" value="halo_sig_pep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04126">
        <property type="entry name" value="PGF_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0701">S-layer</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="819"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="712"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="761"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="761"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG88881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="843" mass="91541" checksum="C63A0E04E1CAAF6C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1I4</accession>
    <name>A0A3N6M1I4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88951">
        <property type="protein sequence ID" value="RQG88951"/>
        <property type="gene ID" value="EA462_11200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043809">
        <property type="entry name" value="DUF5791"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19104">
        <property type="entry name" value="DUF5791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="15374" checksum="6AF86800D96B46D6" modified="2019-02-13" version="1">MFHEQRMSVPDSPDGLRAEYDADLQAALERDDPSAAGDAIDVDRTDIEALSAGESPDLSLEEAAEIQSLAEGTADPETIVTMACEHLLLGMSTAVLDVDAVESELDLELDAKEIQQKIERRAPMSFDEFVHIQYVIVDSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M352</accession>
    <name>A0A3N6M352_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90280">
        <property type="protein sequence ID" value="RQG90280"/>
        <property type="gene ID" value="EA462_09890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039967">
        <property type="entry name" value="MJ1020-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40517">
        <property type="entry name" value="PTHR40517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="93"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="271" mass="30196" checksum="EDA5A80A022ED470" modified="2019-02-13" version="1">MSDPDAETESYRVYSPGADHNFPDEKLNAILEYVDDDEEIQTYLEAQNVNAVDRMQYNDHGQKHIEIVRNRALCLYDLLKASDVDFNGARQQGLEEEDESVIIALAATLHDIGHVVHRDEHVYYSIPLAANVLDRVLAEFYDVADTVRVKGEVLHAILCHHTAETPLTTEAGVIRVSDALDMESGRSRIPYEHGGRGINTLSSQAIKRVSLHEGETSPVLVEIAMTNAAGVYQVDNLLKAKLRGSGLEDSIRIVAVNTNETHEQLVERIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3T3</accession>
    <name>A0A3N6M3T3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86787">
        <property type="protein sequence ID" value="RQG86787"/>
        <property type="gene ID" value="EA462_16770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="195" mass="21642" checksum="1FF5DB9ADB10762F" modified="2019-02-13" version="1">MSSRPDPLDSDSVDDPRASELMENAESGWYGDSAFFGAMAHCPEILTAIGDVFESFGQGEHVDPSLLELMRLKVAESHQCAYCATVRTLEVREDVAPKEDAVFGEVDPEGLSRREYLAISLAADLSTDPHRISDQFFGDLREEFSEAEIVELLLFGSLEVGLDRFCIALELQTTDDSAYPDDLEYPLENPRPKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3T9</accession>
    <name>A0A3N6M3T9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">o-succinylbenzoate synthase</fullName>
            <shortName evidence="4">OSB synthase</shortName>
            <shortName evidence="4">OSBS</shortName>
            <ecNumber evidence="4">4.2.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-(2'-carboxyphenyl)-4-oxybutyric acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">o-succinylbenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menC</name>
        <name evidence="6" type="ORF">EA462_07655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10196"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:58689"/>
            <dbReference type="EC" id="4.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89881">
        <property type="protein sequence ID" value="RQG89881"/>
        <property type="gene ID" value="EA462_07655"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043748">
        <property type="term" value="F:O-succinylbenzoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00470">
        <property type="entry name" value="MenC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010196">
        <property type="entry name" value="OSB_synthase_MenC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="5">
        <location>
            <begin position="143"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="360" mass="38061" checksum="B763792B945A94ED" modified="2019-02-13" version="1">MTGKSNLDLEYRSFSLSLSSPLETASGTIDSRDGFLVRLVDRGEGVTDPATVGYGEATPLAGWTESTADCEEALERARTAFRDDGPEAALESVDRQVAARHAVSLALSDLQANREATPLYRYLCRGPMIGRVPVNATVGDGSPSETGAQTRRAVERGYDCCKLKVGLRSVDADVERLREARRAAGSGVELRLDANEAWTYEEAESVLEAAEEFDVSILEQPLPAGALEGHAALRERARDVKIALDEGVLEHGIDAICESGAADAVVLKPMAVGGIDVARRMAAWTTELELTPIVTTTIDGVVARTGAVHLAASIPDVPACGLATAGLLAEDLGRDPVLLENGSAVVPQAKGLGIDEVWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M414</accession>
    <name>A0A3N6M414_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89961">
        <property type="protein sequence ID" value="RQG89961"/>
        <property type="gene ID" value="EA462_08105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="389" mass="41283" checksum="13C05D7D42766AD8" modified="2019-02-13" version="1">MPNGSRFERSIPTFLTDPHPPIGMSPLIALALWIGLLVAVVVGSAIAAVVGYLFGRLSRRRRDETATRWTNVVTVGSATIAAISSWIVVDAASSVEPAFVPGPEIGSNLVAAIVAGVVAGIVGTAALSGILRARPDLPHVDDPAATRRQYARYLTVLFLGVFALVTLITPAIRAGPGALVVALAVLFVCLWALAPLISSVTSRTRRPTKRERDRLEELLASVDTGVRGVRIVDSGDGRLSLELSGAPRGRYLFVSEGALSNLEDGTLRAMLVARREQAARFERLVAVAPIFAALVVVIGMVLGDLSIVVGGPVAVVVVLGGFALARRLRYRSDARAAQRIGADELADAFERAAEAAGFDLAETPGRNWLATNPPLQTRIDRLRAENDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M559</accession>
    <name>A0A3N6M559_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87829">
        <property type="protein sequence ID" value="RQG87829"/>
        <property type="gene ID" value="EA462_13245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="137" mass="14757" checksum="963277A804FDD3B3" modified="2019-02-13" version="1">MSGKTFVRSEDVSTQVFDWGTIKWMTRPDVTGSERFSAGIVNLDPGSGHELHTHPDSDELLFVISGTGEQVVGDETREIGPGELVYVPENVEHGTMNTGWVPLQLLAVYAPAGPEEVLADLPDCEIVPPGEIPSRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M584</accession>
    <name>A0A3N6M584_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91180">
        <property type="protein sequence ID" value="RQG91180"/>
        <property type="gene ID" value="EA462_04095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="72" mass="8040" checksum="3736862DAAC2A8CE" modified="2019-02-13" version="1">MDDDMLADQRKLVELIEADGWDVTDLEISAYDSPWTDEDDPEATVTITARKPYSSGEGNDGEADDENPYRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5A3</accession>
    <name>A0A3N6M5A3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Isopentenyl phosphate kinase</fullName>
            <shortName evidence="6">IPK</shortName>
            <ecNumber evidence="3 6">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_04210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="3 6"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91200">
        <property type="protein sequence ID" value="RQG91200"/>
        <property type="gene ID" value="EA462_04210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04241">
        <property type="entry name" value="AAK_FomA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="PTHR43654:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="5"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG91200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="250" mass="25813" checksum="52B5A142B7E15E22" modified="2019-02-13" version="1">MIVLKLGGSAITDKDRAETLDGEALESASDAIATALEASAEPGNPNLVIVHGGGSFGHANASDHGVTTTEGSHDIDAVHDIHGAMKTLNGFVLSRLIERDVPAVPVHPFSTASRDQSGRLELPTGQVETMVSEGFVPVLHGDLVSHAERGVTVVSGDELVAELARALEADRVGLCSTVPGVLDDDDVVIERITTLEGVADVLGESESTDVTGGMAAKVAALLDLDAEATIFGLDELEAFLAGERPGTTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5D2</accession>
    <name>A0A3N6M5D2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske (2Fe-2S) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_13790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87929">
        <property type="protein sequence ID" value="RQG87929"/>
        <property type="gene ID" value="EA462_13790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="109" mass="11993" checksum="0EED0ECD3CC9B22C" modified="2019-02-13" version="1">MTEHVVAAADEIPQGKGKAVEVDGLPIAVFNVEGEYYAISNRCVHMGGPLGQGILHSDLPTVDSERTSVHCPWHYWEFDLETGRSVVNEKTGLRTFDVAVEDEQVVIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6T7</accession>
    <name>A0A3N6M6T7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein subunit beta/FixA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89046">
        <property type="protein sequence ID" value="RQG89046"/>
        <property type="gene ID" value="EA462_11745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="262" mass="28258" checksum="CFF90CA3EEFCA574" modified="2019-02-13" version="1">MKILVTVKEVGTVEDEFDIEGTTIADRSLNVDLNEWDDYAIEEAVQLQEAGIADEVVAVTIGPEDCEQTIRQALAKGADRAIRVWDDAIADSDLLDVGAKTEILGAVVEDEAPDLVLTGVQADDDSFGATGVSVADAVGYEWAAVVNHLEREFDDAVSLRRELEGGVEELTTVELPAVLTIQTGINEPRYASLRGIRQAQRKELAVADLAELGIDEDTVEPTLELTEMYEPESESDVTVWEGGADDTASELAALLREKGVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M745</accession>
    <name>A0A3N6M745_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89166">
        <property type="protein sequence ID" value="RQG89166"/>
        <property type="gene ID" value="EA462_12425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="178" mass="21038" checksum="4EB0616800F67D0C" modified="2019-02-13" version="1">MNTAPTEETTGLLEQLEAEANDRNVSTEAYVHEILTNRHAVREANESESELRKQLERRENRIEELEAELAQYSTTEQELRGEIAQLRERTDELSTALSEANDELVDKREYIEGLEEDVSSLRERLESREERITQLETQLARRSQIEDKVSELSMVVREERTARDAPFFVRWWRWMRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M797</accession>
    <name>A0A3N6M797_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA(Met) cytidine acetyltransferase TmcA</fullName>
            <ecNumber evidence="9">2.3.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tmcA</name>
        <name evidence="14" type="ORF">EA462_04265</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43788"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TmcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.193" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91211">
        <property type="protein sequence ID" value="RQG91211"/>
        <property type="gene ID" value="EA462_04265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01886">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="Helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038321">
        <property type="entry name" value="TmcA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024914">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="PTHR10925"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="DUF1726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="Helicase_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="DUF1726" evidence="12">
        <location>
            <begin position="70"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase_RecD" evidence="11">
        <location>
            <begin position="238"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="444"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="560"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="9">
        <location>
            <begin position="535"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RQG91211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="772" mass="83431" checksum="3247D62CE340142E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7D5</accession>
    <name>A0A3N6M7D5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91251">
        <property type="protein sequence ID" value="RQG91251"/>
        <property type="gene ID" value="EA462_04470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="69" mass="7357" checksum="D1F509EAB6850461" modified="2019-02-13" version="1">MIAFRGRLDYPGAAIAVIVGSHRQEITGTDRSLRGRVGSSDGNGHERATVAPADEETESNSDAVFRRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7K4</accession>
    <name>A0A3N6M7K4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91321">
        <property type="protein sequence ID" value="RQG91321"/>
        <property type="gene ID" value="EA462_04885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006562">
        <property type="term" value="P:proline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="2">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="283" mass="31864" checksum="B603D241975C4690" modified="2019-02-13" version="1">MIPPVAGRFIAGETPTEALEYARRRNAAGLDTMLNRLGSHHDDRESVRHDTAEYRELLRDLERVADDPAISVKPTQLGLEIDRSLFRDSLSEIVDRAVDRSVFVWLDMEEHWTVDPTLEASVDLAREHDGGVGVCLQADLKRTRADLERLAGDPLAVRLVKGGAYDRPSPIAYTDPDRRDRAYRALLEDAFDCMDDGIAVATHDPEMIARAVTLSDRHGTDFEIQMLMGVRPTAQRDLATRHDVRQFVPYGERWKRWALNRARRNLSFTARAIVSPIAPSGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8X1</accession>
    <name>A0A3N6M8X1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3267 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89926">
        <property type="protein sequence ID" value="RQG89926"/>
        <property type="gene ID" value="EA462_07910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021683">
        <property type="entry name" value="DUF3267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11667">
        <property type="entry name" value="DUF3267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="305" mass="31816" checksum="961033F5B4EC1DFA" modified="2019-02-13" version="1">MSRTDSQTTASPLAEFRLTRAVASQWLVVSVVGFFAFAYTFGRVLAFARGRPLEPIVISPPDPASALGWIVVSVALVGTVVILHELLHGVAMRRYGGTPSYGVGVSQFVFPAAYATSGNAEYTRTQLIVVLIAPFVGLTGIGLALMAVYPTPLVLVVLAVNAAGSVGDLWMASILAQYPDGAQVVGLPDDERGFALAAPNGDSVDRLPRTVTLSRLVVGSIGTLVVLVASVLLVVFGSLAFGTGTVVIGDPTGRWFLVRHELRSGVAHLEVGASFVVGTSAVAGFVWALLAGILERTSDRLGPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8Z6</accession>
    <name>A0A3N6M8Z6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92730">
        <property type="protein sequence ID" value="RQG92730"/>
        <property type="gene ID" value="EA462_00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="142" mass="15180" checksum="ABAA74D14706CAF2" modified="2019-02-13" version="1">MYETILFPTDGSDHAARVAEHAIDVAETREATLHVLSVVDDRAFLVLDDDRIEHVRKDLRSNALEATDEAATRATDAGLEVETAVDTGNPAECIVDYAATNDVDLIVMGTSGDEYETNVVGSVSQRVVRTAPVPVTTIGPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9M6</accession>
    <name>A0A3N6M9M6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_01960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93000">
        <property type="protein sequence ID" value="RQG93000"/>
        <property type="gene ID" value="EA462_01960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="277" mass="29927" checksum="9FE457B70C8AB770" modified="2019-02-13" version="1">MPESGLGSRLPDLDYGLFAFYLVCVAVLTFILLPVFVVFFYSFFGSAVGGLSRPTLEFYEGAISNNLDAIILSIQIAVITVIVDIIVGVPAAYTLVRYEFPFKRLLTELTILPMAIPGIVIGVAIVRSWGAPRFGIDIGGTVEIIIIGHILFTIPFVIQVTMATLESIDYRRLEESARSLGAGWLRTFVYVIIPNIYSGIIAGSIMAFALSLGEFNISFFVYTPQNTTLPIALFGGFRTATVGEASALASIFILLIVGLLLIVQLISDEGVKLGGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9V6</accession>
    <name>A0A3N6M9V6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_07045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90346">
        <property type="protein sequence ID" value="RQG90346"/>
        <property type="gene ID" value="EA462_07045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="91"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="310" mass="34111" checksum="A7C476AADB0FCD78" modified="2019-02-13" version="1">MFDEEADRELDRGPFQRWAANAITHPERVYRSMFYVATIFFVFTTLFPFYWLLMVALTPEGRQQDIVLTPNGFNPGAFVEVFEVIPFHWYMFNSFVIAAASTIIVLVIASLAGYAFGRLEFPGKVPLMLIVLVISFFPPAAFFIPLNDLFNTQLAVLEPITGDGSLYNTPGAMVLPLSAIFMPLAIFILTTFYAQIPDGLEDAARVEGTTRLGALVRVIIPLSAPGVATAGVLTFIAVYNEFFFSFLMTDGQPENWAPILEGILGYQGQYEVLYHLMAAASIIGVIPVAILVIVAQEKIVSGLTAGALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MA44</accession>
    <name>A0A3N6MA44_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holliday junction resolvase Hjc</fullName>
            <shortName evidence="10">Hjc</shortName>
            <ecNumber evidence="10">3.1.21.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hjc</name>
        <name evidence="11" type="ORF">EA462_03105</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Holliday junction resolvase Hjc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="10"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93200">
        <property type="protein sequence ID" value="RQG93200"/>
        <property type="gene ID" value="EA462_03105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00523">
        <property type="entry name" value="archeal_HJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01490">
        <property type="entry name" value="HJ_Resolv_Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002732">
        <property type="entry name" value="Hjc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014428">
        <property type="entry name" value="Hjc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39651">
        <property type="entry name" value="PTHR39651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01870">
        <property type="entry name" value="Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG93200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="173" mass="19054" checksum="D6159BBE011D095A" modified="2019-02-13" version="1">MSQAKGDRRERELVNELDEAGFAVMRAPASGSATERELPDVLAGDGEQFYAIEAKSSAGDPIYLTGEEVEALIYFAQNFGAKPRIGVRFDREDWYFFHPGDLHVTDGGNYRVKKETAIATGTDFTEFVGRSEKVTLEEITGADDDGPDEEILRILNAVEQGVMDVDEAAELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MAA0</accession>
    <name>A0A3N6MAA0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GIY-YIG nuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93250">
        <property type="protein sequence ID" value="RQG93250"/>
        <property type="gene ID" value="EA462_03395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="84" mass="9706" checksum="64424B71E6B6657A" modified="2019-02-13" version="1">MAESDHVVYVLECADGSFYTGYTTDLERRIVEHDAGEGAKYTRGRTPVALRYHERYESRSAAMSREYEIKQLSRGQKERLVEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBG0</accession>
    <name>A0A3N6MBG0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92801">
        <property type="protein sequence ID" value="RQG92801"/>
        <property type="gene ID" value="EA462_00805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="507" mass="53979" checksum="0C645FDF746B21C5" modified="2019-02-13" version="1">MALSDSVSAVVAVLRRRPGDLLPMYLLGAAIPAIVRVIPFVGVLVGYLYLESTGRLEGIPEQLADLDTTPPDPDASEEAFEAWMSQFQPIVEQVVTLPLVLLVAATAIASVAVLLLLYVVIAAGQIAACAARLRDERGTTAGIAGIRRYWLRFLGLAVLEFLVWAAILMAVGTATILFIGVLALAAPVVGLLVGLLSILVLIGILAAVRALFAFAPVAVVVDDAGVFGSLSKTVGFIRRRPIEAGFYYAISVGTVLAISVVSSFLVIVEVVAFTSLLTVLVVLPALDLLKTALYANYRDRLRAPAQPERSVRTQFRDGIRRGWSEMIGFVRDTPGTHALVVALAVGSFWVGWELAGPYAGIVDASISARLEGHIPPAAALEFFGNNWLVAITTAYAGVALALPAIASLLFNGVMMGALSRLEVDPVELLTFVIPHGIFEIPAIFVASALGLWLGVVGWRAFRGRIDRPTFADALERAFWVLVGIGILLAIAGFVEGFVSPYYAHILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBR1</accession>
    <name>A0A3N6MBR1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92911">
        <property type="protein sequence ID" value="RQG92911"/>
        <property type="gene ID" value="EA462_01430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="163"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="287" mass="32523" checksum="FAA32618BB2719AC" modified="2019-02-13" version="1">MATDYANDVLVTADWVEDRLEDFRDDDSDLRLVEVDVDTEAYEEAHAPGAIGFNWETQLQDQTRRDVLEKADFEELLGSHGISEDSTIVLYGDNSNWFAAYTYWQLKYYGHEDVYLLDGGREYWLENDYPTTDDDPDFPAVEYDAAGPRENIRAYREDVENAIDRGVPLVDVRSPEEFSGEILAPPGLQETAQRGGHIPGAKNISWAAVTNDDGTFKDRDELEELYADEEITGDETTVAYCRIGERSSVAWFALHELLGYEDTVNYDGSWTEWGNLVNAPVEKGEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC27</accession>
    <name>A0A3N6MC27_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93041">
        <property type="protein sequence ID" value="RQG93041"/>
        <property type="gene ID" value="EA462_02175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="4"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="328" mass="36290" checksum="96E920A47D0E4F8D" modified="2019-02-13" version="1">MKILVTGGAGFIGGHLAEQFVRDGHDIVVLDTLVPFYDLGIKERNVEIARTAAAGGDGTYEFVEGSITDADVVEDVVSDVEFVFHQAAQAGVRASVSNPEKTTRTNIEGTFTLLEAARDADVKRVVNASSSSVYGKPEYLPYDEDHPTTPVSPYGASKVAAEHYVRVYNEVYGLPTVSLRYFTVYGPRMRPNMAFTNFVSRCLHGESPVIYGDGTQTRDFTYVEDVVGVNRDLLSTDAADGEVLNVGSTGRITIDDLARVIRDEIDPSLEIEYDDPREGDAKHTHSDVSKARELIGYEPSVSIEEGAKRFVDWYRENEDWYDPLVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCR1</accession>
    <name>A0A3N6MCR1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RimK family alpha-L-glutamate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93291">
        <property type="protein sequence ID" value="RQG93291"/>
        <property type="gene ID" value="EA462_01555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="90"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="307" mass="34208" checksum="0A9CC5AA8F48C22D" modified="2019-02-13" version="1">MIDLAVANATQTFRRMREPLAECGVRVHHVPTSERVVDLTDPPWSPDEYDAGFVYPGRLMEGGVADALLEIPWLNDHEAVLTSRNKAEVLARLERADLPVPKSVYVSNDVDEGELATVFDRFEPPVVVKPNSTTRGVGVAKAHDLDSFLGICDYLSLVHDYRATGDRSFLVQEYLPHAADYRVMVLEGEYVGAVERRLPDDAITDGHWKHNVHRGAEATGVSLPASHRELAEAVAAELEIPLLGVDLLEADGRLVVNETNARPTIDEETKYEPEFYDRLAAAIRSTMAPETDRTENDRDRDARITRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSB5</accession>
    <name>A0A3N6MSB5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87123">
        <property type="protein sequence ID" value="RQG87123"/>
        <property type="gene ID" value="EA462_15070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="167" mass="18914" checksum="D59EAD71AABE3E7A" modified="2019-02-13" version="1">MSGRERVRHVVELLEEPTPVQEIADRADVSRATADDELQQLKSDDWVTETTVDGTKAYDLNPVRILFDEVTDLIEAHSRDGLESQLTELKEEQEALAAEYDASSLNEFRKQLADEEFSAEELRERRNVIATWEAINTELGLVKHALQLYDDVIELSSPRTDSPSTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSP9</accession>
    <name>A0A3N6MSP9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_12940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87775">
        <property type="protein sequence ID" value="RQG87775"/>
        <property type="gene ID" value="EA462_12940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="551" mass="58658" checksum="166974C74EE8CF8F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSU9</accession>
    <name>A0A3N6MSU9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87835">
        <property type="protein sequence ID" value="RQG87835"/>
        <property type="gene ID" value="EA462_13275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="149" mass="16466" checksum="FFA931C1A01C85A9" modified="2019-02-13" version="1">MIGTAHHYGVTVSNLDDVLPFYRDTLGLEVISEGHVERDTEDSEKFEHFVGVDGAVDVEVVFLDAGGCQIELLQYNHPPGDDAHGANNNDAGASHFCLEVDDIDAVYEELTDEGIEFIYEPITLSKGVRVAYMYDPEGNVVELSDRSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MT04</accession>
    <name>A0A3N6MT04_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87905">
        <property type="protein sequence ID" value="RQG87905"/>
        <property type="gene ID" value="EA462_13665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="473" mass="50258" checksum="33670BFD8A2DA80A" modified="2019-02-13" version="1">MLRSLVSFLAGLLERGNIIERSRLRATVDLAWPRVVTGFARMSKQTADVAMVGIVLGAPAIAGLAFAYAYWQLVARLSLGLSGGTISLVSQYYGGDQPSLANRAITQSCLLATVFSAPFIVLFAFGSEGLIGLLGAEPAALEYGTIYLTLLAPALLFEFYNKIASRVFAGIGDTLTPMVIRAGGAALNIVLNAILIFGLEMGVAGAAIGTVVATVLITAGLAWGLFGRPYPRRGRLPVRLTLAGPTVDMTLLRPLVRVSTPLIFQEVARAVAVFPLLAIAGIFGSTVVAAYEIGRRIRDLMNSLSWGFSIASSSLVGRHLGANEEEIATNYGDEIIRFSLVAYVIFASLVIFFADSIAHLFVTDPETLSLATTFIQIAAIATIGLGIDSSATGALRGAGDTRWPFYGALIGLYVFTLPIAYLGVITPLGVAALYVAMLTETYISAAITYYRYRTGAWRGVSRSIRERAGQSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTA7</accession>
    <name>A0A3N6MTA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88025">
        <property type="protein sequence ID" value="RQG88025"/>
        <property type="gene ID" value="EA462_14310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="7127" checksum="6C0619DAA791F4C1" modified="2019-02-13" version="1">MDAADEYDRTLETMLKRAESQLGLEFGRISLDSGLGNTKIMDVCEKYGLNWLIQGQMNGNGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTS9</accession>
    <name>A0A3N6MTS9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CTP synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88782">
        <property type="protein sequence ID" value="RQG88782"/>
        <property type="gene ID" value="EA462_10265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="108" mass="11765" checksum="7EAAF10C52A5670E" modified="2019-02-13" version="1">MSRKVIVAGPDDDDIAPALENEGADVHRLDGVLTRPRLEEVGIVGAELYVLTDIDQATSIPIVCDLSDQIRTVVYSRKTIPEFVRGQLDLSVDPRLVDPAVVADELVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTY6</accession>
    <name>A0A3N6MTY6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_10600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88842">
        <property type="protein sequence ID" value="RQG88842"/>
        <property type="gene ID" value="EA462_10600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="257"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="654"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1121" mass="128799" checksum="955FEECD2EA27987" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MU03</accession>
    <name>A0A3N6MU03_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">speB</name>
        <name evidence="5" type="ORF">EA462_10710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88862">
        <property type="protein sequence ID" value="RQG88862"/>
        <property type="gene ID" value="EA462_10710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG88862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="314" mass="33701" checksum="199E829E4629AF91" modified="2019-02-13" version="1">MIDPQEVPRFAGVPTFMRSPHVYDLETASPDIAFLGVPYDDATSFRPGARFGPRAIRLASTLLKPYNPVTETDLSPVTIVDHDDVPVVPGYTEETFARIEARVSSVLETDVFPAIAGGDHSTTLAVLRAVAEKYGPVSLVQIDAHSDLWTEYFGEPYSHGTTVHHAIEEGLIDPSSSIRIGERGGLYGPEDVDRHDDAGIEYYPIDELEDRGIEEIGDRLRERVDGPTFATLDIDAVDPAYAPGTGTPSPGGLTSREFLRLIRSLRGTTLVGFDLVEVAPPYDDAAGSTATLAASATFEALCAAVDSSGPAGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MU46</accession>
    <name>A0A3N6MU46_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="6">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">carB</name>
        <name evidence="9" type="ORF">EA462_10990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88912">
        <property type="protein sequence ID" value="RQG88912"/>
        <property type="gene ID" value="EA462_10990"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="139"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="702"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="6">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="6">
        <location>
            <begin position="977"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="852"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="881"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="883"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG88912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1074" mass="116318" checksum="70A6BA9116DCB109" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUC3</accession>
    <name>A0A3N6MUC3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_11370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88982">
        <property type="protein sequence ID" value="RQG88982"/>
        <property type="gene ID" value="EA462_11370"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine_dh" evidence="10">
        <location>
            <begin position="138"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG88982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="315" mass="32634" checksum="D0D35E1F4E4875F0" modified="2019-02-13" version="1">MRLAILGAGDVGRSVADLASEYGHEVVAIADSSDAAVDPSGIDVERTLERKVGNEPVGTAAPEDVFETEYDVLIEATPTTLDDAEPGFTHTKRALEADRHVVLANKGPVAERYGELRALEAESAGSIRFEATVGGAIPVLSTIEDSTPQAVTTVRGVLNGTANFILTRMAAEGLDYEHVLAEAQDLGVAEADPTFDVDGTDAALKFVILANVLSDGGFSLSDATVEGIQNIPGSALDLAAEDGRTIRLIGEATRESVRVGPRLVPENGALAVTGTRNIVQIETRHAGSLASSGRGAGGPETATAVLSDVGRLPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MZR2</accession>
    <name>A0A3N6MZR2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91092">
        <property type="protein sequence ID" value="RQG91092"/>
        <property type="gene ID" value="EA462_03580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="119" mass="12946" checksum="3098872FE6C58538" modified="2019-02-13" version="1">MQTELSSADDVNVPQYDQPNDRYVFHYDSDGTATITTTIVHAIASIADIDVSQGEFSLYDSVDPDALEHIFSQKADGTDRTGGHVAFSALEHEVYVYANGDVIIYPPTDANVSHPPVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MZT7</accession>
    <name>A0A3N6MZT7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Replication protein H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91122">
        <property type="protein sequence ID" value="RQG91122"/>
        <property type="gene ID" value="EA462_03760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043855">
        <property type="entry name" value="DUF5817"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19134">
        <property type="entry name" value="DUF5817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5817" evidence="2">
        <location>
            <begin position="31"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="174" mass="19229" checksum="87C02D74242F9B53" modified="2019-02-13" version="1">MYAVVGCSECSNLWIIEGRSETTQCPRCGSRKAFEKRKKFVETDDADHAREVRASMLANRQGQGDAFAAVDSFADLENDVSDGVVDETEYIERSGLDADELEAAGDRDPRGPSRAGSKADIVECALEELDRPTEAEVIDYADERGVSAAYVRDTLEKLVRRGAVSENRGRYRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N066</accession>
    <name>A0A3N6N066_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_04530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91262">
        <property type="protein sequence ID" value="RQG91262"/>
        <property type="gene ID" value="EA462_04530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="102"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="222"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="6">
        <location>
            <begin position="287"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="365"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="575" mass="62647" checksum="ED94CF971452F1E0" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0V0</accession>
    <name>A0A3N6N0V0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="1">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamylcysteine synthetase</fullName>
            <shortName evidence="1">GCS</shortName>
            <shortName evidence="1">Gamma-GCS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gshA</name>
        <name evidence="2" type="ORF">EA462_06225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC), the main low-molecular-weight thiol compound instead of glutathione in halophilic archaea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91552">
        <property type="protein sequence ID" value="RQG91552"/>
        <property type="gene ID" value="EA462_06225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="362" mass="41147" checksum="8843294E9D5D2C34" modified="2019-02-13" version="1">MERGSPESFTRMGTLGVEEECFVVDETGRPTSGTDELVYEHDPPAILEERLDHELFKFVIETQTPLIEEPDDARDALLEIRRALSEHAHAHGYQIAAAGLHPLAKWRELEHAEKPRYRSQLDRIQYPQHRNTTAGVHVHVGVDDADKAVWIANELRWYVPIILALSANSPYWNGFDTGLESARAKIFEALPNTGMPTYFEDYEAFDRFERRMLETDSIADRGELWYDVRPHTAHGTVELRTPDGQADPDVVLAFVEYAHALVEALAAEYEDGATGRAPDHRRELLDENKWRAIRHGHDASFIDRDLEGTISLGELVDRECERLGIDGIKRVYERESGAERQRRLLETTGPDALCESLLLGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N134</accession>
    <name>A0A3N6N134_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dipeptide epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_06805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91652">
        <property type="protein sequence ID" value="RQG91652"/>
        <property type="gene ID" value="EA462_06805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016855">
        <property type="term" value="F:racemase and epimerase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03319">
        <property type="entry name" value="L-Ala-DL-Glu_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034603">
        <property type="entry name" value="Dipeptide_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00010">
        <property type="entry name" value="dipeptide_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="4">
        <location>
            <begin position="140"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="346" mass="37606" checksum="E2855D8DCA8C3C30" modified="2019-02-13" version="1">MSLETSVHRRSLPLEYPFTIARGTVTETDVVTVHVEDGEGRIGIGAASPASHYGETAATVEAVLPDLLSIVEDVDDPSQHARIERRMRETLRENPAARAAVSIALYDLEAKRLEVPLYRYWGLDPAESLETSYTIGIDDLETVREKTETALDRGHGTLKVKLGTGRDDEIVRTIRSVAPDARLFVDANEAWSPREAVSTIERLAEYDLALVEQPVPARNLEGLKFVSDRSPVPIAADESCVTLADIPQIADRCDIANLKLMKCGGLREAWRMIHAARAHDLDVMCGCMTESNASIAAACHLAPALDYADLDGSLLLSDDPYDGVPIVDGRIDLEALERPGSGAAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3X1</accession>
    <name>A0A3N6N3X1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_01105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92852">
        <property type="protein sequence ID" value="RQG92852"/>
        <property type="gene ID" value="EA462_01105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="317" mass="34293" checksum="927BC0F398ED65D5" modified="2019-02-13" version="1">MSIGRYALRRTLISIPVLLGATAITFSFVHIAPGDPVDVLVGFDAVDDATRDALRAEFGLDRPLWQQYLLWLADVLVLEFGESPITGREVGATIGDRLPATLLLGLSAWVLSLSIGIPAGIFAATNQGEIEDEVGRIAALAGIATPNFWLGLVLLFVFGVQLGWFRVTPPDASLLSLEMLWFMVLPAITLGTAAAALVMRLMRASMRQELRKEYVMAARARGLSERTVVLKHALRNSLTAVVTVAGLQIAFLVDGAIVVEQVFSWPGMGLLLVESVGRRDLPVVQAIVLLIAVSVVVANLLVDIAYAVLDPRIRYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVZ3</accession>
    <name>A0A3N6NVZ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88092">
        <property type="protein sequence ID" value="RQG88092"/>
        <property type="gene ID" value="EA462_13160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="124" mass="13284" checksum="F0F368EF8034605F" modified="2019-02-13" version="1">MKEISTNAAPASIGPFSQGIHDGDRLFVSGQGPVDPETGEIIDGGIRDQTKRSLENIEAVLQAGNSSLENVVKATVFVQNMDDYDAINDVYGSYMTEPYPARSAVQVEDLPIDIGVEIEVIATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWK0</accession>
    <name>A0A3N6NWK0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88919">
        <property type="protein sequence ID" value="RQG88919"/>
        <property type="gene ID" value="EA462_11025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="318" mass="33591" checksum="157C46822238490A" modified="2019-02-13" version="1">MARLFPFRSETTTRDGQPRVVDLEGEDGDAVFSALSSTTARRIYARLDEDPGTPSDVADAIDSSIQNVRYHLEKLEDAGLVEIVDTWYSSRGNEMSVYATTDGPLIVTSDESTASQLKTAISRLIGGIGALAGGSLLVQYGASRWFGASGGVLDESAPATGEERTPADDGDETTGEEYTVGDDRHEEPTDAPDEEAPPEDEELEAETADDEDAANDDELEEDAEDADALDEPEADVSTEEDADALDDEPATETTDEPSSSFDSAAEPAADDGTIVADGGAEAADAAVGTLPPGLVFFLGGLAVLVAVSIYWYWYRPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZK5</accession>
    <name>A0A3N6NZK5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">cobS</name>
        <name evidence="20" type="ORF">EA462_15230</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86996">
        <property type="protein sequence ID" value="RQG86996"/>
        <property type="gene ID" value="EA462_15230"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00317">
        <property type="entry name" value="cobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RQG86996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="252" mass="25457" checksum="925E95A7C730861E" modified="2019-02-13" version="1">MIGRLIGAVRGAFGFLTRLPVAHRDGDWDAFRSTPLAFPIVGLVAGAIASIPLFGTEVLPPTAVAFGYVLAVYAVTGVHHLDGVADLGDALVVHGDRERRREVLTDTTTGVGALLAVTIVVVGLALGGLGLAGLPVLIAVGIVIGAEVGTKLAMAVVACFGTASYEGMGRQITEASTPGGFVVPAGIVIPAAALAWPHPGTVALCGALAGVALPWYWARRFLGGISGDVFGAANEIGRVAGVHAGVIAWTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0E4</accession>
    <name>A0A3N6P0E4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87928">
        <property type="protein sequence ID" value="RQG87928"/>
        <property type="gene ID" value="EA462_13785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="85"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="376" mass="42893" checksum="A7973BE457D9C43A" modified="2019-02-13" version="1">MSVIDSERFPLTDEMEEAFVVDVDFHFRAPVDRLMPYMDSAVVKRNLDITGYPPTSCYWFPGYSTPRGAGGLEAHGELETGEDIVEVMEALGIDMPILTPGYNKLPDSQNVVMKNEISRAYNDYLVDDVLPTHENIKAVALMQQWEPETAVEEIKRVGDEEDIVGMYGFFGHYDLLGQPKYDQVFEELVARDLPLALHGGGTANWPQKDLIGNSLRTWSEAYGLVHPCRAMMMAGNMIMTGVFDKYPELQVVMIEGGVNWVPFVSERLDEMYNDHPEDIQMTERMHRMGQEYLDKQPSEYLEENFSFSSQPMNIPNKTSNFEAMLDMTNASNSLMFATDFPHYTVELHNWVLESPAIDDELAERILHENAESVFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0V6</accession>
    <name>A0A3N6P0V6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91099">
        <property type="protein sequence ID" value="RQG91099"/>
        <property type="gene ID" value="EA462_03620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="189" mass="20856" checksum="1399BAAC69F973CD" modified="2019-02-13" version="1">MVRGDSTRHDRITRHPTPNARNSLADWTDARHPVRVAITYVVVWLVRISPSLRLKRWLLRRIGVTVGEGVSWGLEATPDVFWPELITVEDHAIVGYDATLLCHEFLQDEYRTGEVVVGERAMIGAGAIVLPGVEIGANASIAANSLVTTDVEPGTTVAGVPARPMGAESDERNRRRTREENADEPDEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0W7</accession>
    <name>A0A3N6P0W7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91119">
        <property type="protein sequence ID" value="RQG91119"/>
        <property type="gene ID" value="EA462_03745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="116" mass="12243" checksum="F7484C5186A8DCE0" modified="2019-02-13" version="1">MDLTDSDIGGDVTGHYEPVSIEPTAVDGSVRTTDDVQMVDGTVVEGDLETDSGTLSLDDATIVGHAFARTTPTSSVTATRRSTASTVEAIVDFRSICSFYILYGRVKQTRPIALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P188</accession>
    <name>A0A3N6P188_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91249">
        <property type="protein sequence ID" value="RQG91249"/>
        <property type="gene ID" value="EA462_04460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="180"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="368" mass="39422" checksum="968D6CA80A0290D4" modified="2019-02-13" version="1">MNTALLSRESDSDTLTLGILGVGNIGMVHLKSARVMANVDVLAAADAVPENRQRAERAGVDRTYEDYATLLDSESIDVAVVALPPFLHADAVERAAEVGTDVFVEKPLARSTEEADRLLEAAKSGGIAVGVDHTLRYQPDVTGVKAAYDDGRVGHVPYASMTRLNDGPLGRPPVERSPPGWALDADAAGGGSLLELGIHCFDVLEWLFGDLEVQSAATGCTLNLPIEDAATVLLRAPETGTTITLHCGSYQWEELPKVNTRLRLEGITGTISNEDYLPENFYASAATSALSNVASRVTGDEPDVFGPTFYLRAHYDALEAFLDAIRADESPPVEGTDGRRSIELAEDAYDHAARRGSEELEMPEVTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1I0</accession>
    <name>A0A3N6P1I0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88935">
        <property type="protein sequence ID" value="RQG88935"/>
        <property type="gene ID" value="EA462_11120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="300" mass="32554" checksum="467B5340C53461B5" modified="2019-02-13" version="1">MVLSVVVSTLNDREQLLSCLDALTERTPPRTEVIVVNGPSSDGTTGVVRERTDVDVLVEISERSPNVSRNAGLEAATGDIVAFLDGACTVEPGWYDAIERSLETEVDIVSGPITGRKTTVDDLGHTRTVAGRSVTPFDADNVAFDRTVLDALDGFDEYLDVGGDRDCAHRVAGLGFEVDWCGEMAVRSEIEADGGTTQSEWGSAYRSLSYRLAKNYGPRPTVLIRTVASAVRDGVFGVRRIFSGDVTPTGWVSDGIEVLTNVACGARDGLRARYADRSARRNPNGISVRHDRAVRLYDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1M6</accession>
    <name>A0A3N6P1M6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91419">
        <property type="protein sequence ID" value="RQG91419"/>
        <property type="gene ID" value="EA462_05460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="206" mass="22235" checksum="0A9F834B34DE81AF" modified="2019-02-13" version="1">MYHDVLIPTDGSDGTRRSIVHGLTIAERFDATVHALSVVPEGPLGTLESEEATPAAHRAVDHVAATAKRSGLEAVTAVDHGVPHEEILSYADEHGIDMIVMGTQGRTGLDRVLVGSVTERVVRMADVPIVTVRLTDDRRIETSEEAEAIARESLEESVTDSGDEAKTRDSYRISATWYVEFGTSSGPIQVQVDAVSGETRRSNVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P287</accession>
    <name>A0A3N6P287_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">EA462_03925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91689">
        <property type="protein sequence ID" value="RQG91689"/>
        <property type="gene ID" value="EA462_03925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="31"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="299" mass="32568" checksum="9460A226611AE4A8" modified="2019-02-13" version="1">MKPRDPDALIARAGVRGNPDRDQHFLVDDRVLDRLPTYLTDIDADTSHVLEIGGGTGALTDRLLAAAGDGGTGADRDEGDRSVDGGVTVVERDPDLAAFLREEFAEQIDAGRLTVIEGDALEVALPEFSASVSNLPYGVSSEITFRLLPEQRPLVLMFQREFAERMVAEPGTSEYGRLSVSTQHYADVELVETVPRQAFSPQPAVQSAVIRAVPAEPDYEVDDEDFFFRFVKALFTQRRKTIRNGIRNTAHISGLSDPEAVVEATDEAVLRKRPDAMSPAAFAELTQLALTVDSPDGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P584</accession>
    <name>A0A3N6P584_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93229">
        <property type="protein sequence ID" value="RQG93229"/>
        <property type="gene ID" value="EA462_03275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="43"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="226" mass="25602" checksum="B66B901A5770C2F2" modified="2019-02-13" version="1">MSVREEFDEWAANGKDRGMEERHWHTAKHALARIPLEPGETVLDLGCGSGYAGRALRETKGAGRVYGLDGAPEMAHNAAGYTDDPAVGYLVGDFDSLPFADDSIDHVWSMEAFYYAADPHHALEEIARVLRPGGTFYCAVNYYEENVHSHEWQEFISIEMTRWDRSQYREGFRNAGLSVGEQDTIPDREITIPSEEEFPTDDWDSREDMVERYREYGTLLTVGVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P5B7</accession>
    <name>A0A3N6P5B7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93289">
        <property type="protein sequence ID" value="RQG93289"/>
        <property type="gene ID" value="EA462_01455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="344" mass="36927" checksum="B5F97BAC297DB943" modified="2019-02-13" version="1">MTTEHTPLEEQVIVVTGASSGIGLTTARMAADRGAKLVLAARSEDALEELTAEIEDDGGDAEYVVADVRNRDDVREIAETARQSYGGFDTWINGAAVSIYGRLADVPVEEMRDQFDTNVWGLLYGSLEAADHLRERGGTIVNVGSVVSERAMMLQGSYSASKHAVKAFTDALRMELEDEGAPVSVTLVKPGAIDTPYPTHAKNHMDEAATLPPPVYAPETAARAILHAAEHPRREVTVGGGGKQLTVLGQHAPRLMDALMKTIFSRRQRTGDPPRPRDEHGLHDAAGDLEERGDYEGHVAETSLYTRIVQRSPIPAGAVVGGAVAVSAALAYRAVRRRNESADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P5E5</accession>
    <name>A0A3N6P5E5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin--nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_03325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93329">
        <property type="protein sequence ID" value="RQG93329"/>
        <property type="gene ID" value="EA462_03325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="4">
        <location>
            <begin position="51"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="3">
        <location>
            <begin position="143"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="4">
        <location>
            <begin position="320"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="3">
        <location>
            <begin position="399"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="569" mass="63286" checksum="94BD89D0586A8552" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P994</accession>
    <name>A0A3N6P994_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="8">ATP-PRT</shortName>
            <shortName evidence="8">ATP-PRTase</shortName>
            <ecNumber evidence="3 8">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisG</name>
        <name evidence="11" type="ORF">EA462_00595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="3 8"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92765">
        <property type="protein sequence ID" value="RQG92765"/>
        <property type="gene ID" value="EA462_00595"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="9">
        <location>
            <begin position="49"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="10">
        <location>
            <begin position="207"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG92765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="283" mass="30470" checksum="335A08F37DE4822E" modified="2019-02-13" version="1">MRIAVPNKGRLHEPTIDLLERAGLHLENGADRKLYADTVDPDISVLFARAADVPEYVADGAADLGITGLDQVHEARVDTVSELLDLEFGRCRLVLAAPEDGAIETVADLAGKTVATEFPNITREFFAETGVEPDIVEVTGATELTPHVEMADAIVDITSTGTTLKMNRLAVVEDVLSSSVRLFGREDVLDDPKVREVRTALASVKQAEGKRYLMMNVPEDRLSDVRDVIPGMGGPTVMDIANGGEKVAVHAVVDEADVFETINDAKQAGASDVLVTEIERLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9C1</accession>
    <name>A0A3N6P9C1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92815">
        <property type="protein sequence ID" value="RQG92815"/>
        <property type="gene ID" value="EA462_00880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="103" mass="12237" checksum="CD7F0992F33CB59F" modified="2019-02-13" version="1">MADRRRLERFLRSKLREAGEEYEQLRESTDGQLEEAREAYRVAKNARRLPTDDAGRARIVCRRYAQQRAAMIDERYRPACYEADHPDCEGCVEDVREGRIETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9T5</accession>
    <name>A0A3N6P9T5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93045">
        <property type="protein sequence ID" value="RQG93045"/>
        <property type="gene ID" value="EA462_02200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="368" mass="40877" checksum="65A540E3F6E210C2" modified="2019-02-13" version="1">MVEATFFTHNLGVGGAQRVLVNLSTELAKRGREIEIVVHTDKGKLASEVHDDVNIYYTNTPNFVPTIRSLRSYLRDRHPDVLLSTVNIANLAAIIAGKTTNTDTHHVVRMANTPSKKAQDYENKQIRHKVVPYMMRGLYPLSDEILAVSAGLKDDLVQSYGIDPSKIRVIYNPTVTQAVFEKAEQPVDHRWLDDPSQDVILGVGSLIKQKDFETLIKSFCRVQQRIDAKLLILGKGNQRDALGRLVQDLGLTSQVDLYGAVANPYSYMANADLFVLSSRWEGCPNVLIEAMACDTPVVSTDCPNGPREILRNGEYGPLVPMGDSNTMATAIVDQLENTSQFSNVKDRAMDFHVNVIADEYEKLLFGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI33</accession>
    <name>A0A3N6LI33_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Archaellar assembly protein FlaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">flaJ</name>
        <name evidence="8" type="ORF">EA462_16575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86749">
        <property type="protein sequence ID" value="RQG86749"/>
        <property type="gene ID" value="EA462_16575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="96"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="575" mass="64135" checksum="BAFA77F782D25D9A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIP0</accession>
    <name>A0A3N6LIP0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87109">
        <property type="protein sequence ID" value="RQG87109"/>
        <property type="gene ID" value="EA462_15900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="164" mass="18489" checksum="FF19E4911F68DA08" modified="2019-02-13" version="1">MKVRYYADAEIREMHNHAIRLLAQLHDDHDITVEIDRIDEQHDPITDFPGEVRRLSAEEVYERDLKRNRALNAVIEQTPSEAFKHYGKLDIAGNVAVVDEEGTVQWASTLPGYADGYGPGAEAQTAMDFLEDISTSPSNRICIECLHLLDGDENFCPNCGYDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIW1</accession>
    <name>A0A3N6LIW1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87926">
        <property type="protein sequence ID" value="RQG87926"/>
        <property type="gene ID" value="EA462_13775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="1">
        <location>
            <begin position="19"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="474" mass="51055" checksum="709F87C4CB834C0B" modified="2019-02-13" version="1">MDIPNEWGLRIGGTEQFRSNTFEVANPATDERLSTVADASAEDATRAIETASTAFETWSEWDASERGRLLSRISERIRDDVDAIATLETLEVGRPLDHSRQRVEAAASFFEYYAGLADKIEGDTIDVPGDRLNYTIREPLGVTGHIIPWNSPILLGSRSIAPALVCGNTVVAKPSPEAPMTILRLAAICEEAGLPAGTINVVPDADAAAGKAITSDSRVAGVSFTGSPDGGKHVMKSAAEHVSHVDLELGGNTPCVVFPDADIEKVASEVVDCYHNAGQICYTISRFFVHGEVYSEFADALVQEIEALAIGPWTEEPDVGPVISAESQRRIDQYVTEAEENGARILAGGTVPRETGHFYEPTLVDGVSDSDSIVCDELFGPVKTLHEFSDEAEVVRRANDTVYGLYAVVYTKDIDRAHRLAGAMEAGAVAVNEFPLVFVQTPFGGYKESGIGRTKGRHAIENFTQVKNVTIGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ00</accession>
    <name>A0A3N6LJ00_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_13035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87791">
        <property type="protein sequence ID" value="RQG87791"/>
        <property type="gene ID" value="EA462_13035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="335"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="448"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="7">
        <location>
            <begin position="520"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="808"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="415"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG87791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="853" mass="91660" checksum="78CDA3BAA5BFCE41" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ08</accession>
    <name>A0A3N6LJ08_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Yip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87801">
        <property type="protein sequence ID" value="RQG87801"/>
        <property type="gene ID" value="EA462_13085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="6">
        <location>
            <begin position="4"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="214" mass="23408" checksum="782F45E751B0C4F0" modified="2019-02-13" version="1">MATGFVTDPEGFLRKKAATGRLWIPSLFAVLVGIALLSQTWLIRVQLGGEFLRVIDALIIWGMFRVIEGFIIWIYFIVAFWAMGIALGGKPLLGHVIRVAGWGLPPFIIAGLVWGAGYYYALRDATLLEYDLQGIEAEWELLADYKAQAVGDPYLVGATLLGSGVLLISAYIWVNGVKTACDLDKRNATIAVGVPLALYVLYRFLAIYGILPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJH0</accession>
    <name>A0A3N6LJH0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88833">
        <property type="protein sequence ID" value="RQG88833"/>
        <property type="gene ID" value="EA462_10555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="202" mass="23198" checksum="19B25886F205B2F4" modified="2019-02-13" version="1">MVLLEKPDRERGFNKERIIRVLLNHADGKLTKYRIAKLSGASEPWTRQYTDKLENQGLIQDTEVVEVEELYREWQRTRIKPSQLEVSLQQPMQLLEDTGLKYALTTYQAENLHQGFLFASTTDFYISPDQTNDWLNIIEEKGLLGGGNTRVRVLDEHVFYNGKTADDFSTVSIPQLILDLLDEGGPCREAAEKLIQNFHGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJH4</accession>
    <name>A0A3N6LJH4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine pyrophosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_13030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88091">
        <property type="protein sequence ID" value="RQG88091"/>
        <property type="gene ID" value="EA462_13030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="198"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="403"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="578" mass="62543" checksum="7938D47716F44A7B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKQ5</accession>
    <name>A0A3N6LKQ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87058">
        <property type="protein sequence ID" value="RQG87058"/>
        <property type="gene ID" value="EA462_15605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="131" mass="14000" checksum="7E31C809AE9C6A10" modified="2019-02-13" version="1">MSDNQSLGARLKEDLTSNLSVSVVSVILAVVAWFVFAQIGDPTTGGLFLALNIGVFIPYAYERYWPVAYSSSAAVVWTISAALITAGLFIGTYQLALGVVPGEYTGGIAFVLTVLIQYGIAALFMRVRQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LL94</accession>
    <name>A0A3N6LL94_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87840">
        <property type="protein sequence ID" value="RQG87840"/>
        <property type="gene ID" value="EA462_13310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="35"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="113" mass="12475" checksum="8765404FE70801A7" modified="2019-02-13" version="1">MGNIVYDSDLVEQSISDGFHVTRIGRNDLMSIQRWVCDPGGSFPEHSHPHQQIGYVYRGEMHVSIDGEQYVLGPGDTYIVEGNETHAGTNEGDEPAEGVDIFSPPLKDSDWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM26</accession>
    <name>A0A3N6LM26_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90123">
        <property type="protein sequence ID" value="RQG90123"/>
        <property type="gene ID" value="EA462_09025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="14"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="332" mass="36072" checksum="CA4E515389E7A080" modified="2019-02-13" version="1">MDRITLGNDEFEGRNNVYVLLDEETDDLALVDTGVSAPDIRADLEDGLAARGYGLEDVDDIVLTHFHVDHAGLAGEIQAESDATVFVHEADAPLVEHDPEAMTELDERRRELLDVWGVPAEATAELLSILDGTREIDGKPADATPIEDGTILEVGGRTIETVHAPGHAAGLCCFEIVDGGDGGDGSEAFVGDAILPVYTPNVGGADVRVDRPLEQYLETLRTIVDRDYDRVWPGHRDPIDEPTDRALAIADHHRDRTERVLDVLEEHGPADPWTVSAHLFGDLSGIHIVHGPGEAFAHLDHLHHEGVVSLEGGEYRLIESDVDLEEIVGTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMD2</accession>
    <name>A0A3N6LMD2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AbrB/MazE/SpoVT family DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90168">
        <property type="protein sequence ID" value="RQG90168"/>
        <property type="gene ID" value="EA462_09270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="76" mass="8592" checksum="1DAC2E2DD4DC48B7" modified="2019-02-13" version="1">MSDVALDDRGRLTLPKEVRERYGDRYHVVQLPDGVKLVPVADDPLEALRDEFADVEKSVDELREEARNAALDEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMD6</accession>
    <name>A0A3N6LMD6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_16210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86685">
        <property type="protein sequence ID" value="RQG86685"/>
        <property type="gene ID" value="EA462_16210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="23"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="387" mass="43033" checksum="616BDA5AA99AAD98" modified="2019-02-13" version="1">MSTHETTVTDEQSHSVSDPILEIRNAEVVFEMDRGVSRVLDDVSLEIERGEILGVVGESGSGKSMLASSTLDAVVEPGVLTGEVTYYPEDGDPVDVLDLTPAELRRLRWEEIAMVFQGAMSSFNPTMKIRDHFEETLEAHDYSLRDGMSRAHELLSDLYLDSERVLDSYPHELSGGMQQRTLIALSVVLQPNVLVMDEPTAALDLLMQRSIISLLEELKSKYDLTMVFITHDLPLVAELADRLAVMYAFELIEQGPTQELLHDAGHPYTRALLNSTPNLDAPLEEMRPIPGSAPDPVDVPTGCSYHPRCSLATDRCVAKAPASEPITAAHTVDCHHWKDAVDAISLNHRKQVGSETQNRQQRPETSDRTRTRTEMNHQDQTSPEGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMK5</accession>
    <name>A0A3N6LMK5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ORF">EA462_09830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90268">
        <property type="protein sequence ID" value="RQG90268"/>
        <property type="gene ID" value="EA462_09830"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="2"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG90268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="442" mass="47777" checksum="14F396FC64EA5D30" modified="2019-02-13" version="1">MTEKSTESKVEEAQTAALELAKYSNDERSRAIRSIADAIDARRDEIIAANATDVEEAERLLEAGEYSRALVDRLKLSPSKLESITDMVRSVAGQDDPLGKTQTARRLDDDLELYKQTVPIGVIGTIFESRPDALVQIAALALKSGNAVILKGGSEASESNRVLFEIIREATSEAPAGWAQLVEARADVDALLEMDDSIDLVMPRGSSAFVSYIQDNTSIPVLGHTEGVCHVYVDSEADLEMATEIAYDAKVQYPAVCNAVETLLVHEEVAEAFLPATIDRYAEAGVELRGDDASRTIVDIDAATEEDWATEYGDLILSITVVDSLEAALSHVNAYGSKHTESIVTEDSDRAATFMRSLDSASVFHNASTRFSDGYRFGLGAEVGISTGKIHARGPVGLEGLTTYQYYLEGDGQVVGTYAGADAKEFVHEDFDGSWTPGSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMR1</accession>
    <name>A0A3N6LMR1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89107">
        <property type="protein sequence ID" value="RQG89107"/>
        <property type="gene ID" value="EA462_12095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="261" mass="28306" checksum="A3BF44BA8F5B972F" modified="2019-02-13" version="1">MAASPPPTLSAAFDDPRISDRFCRRLSGPAGNLILLGVVHDHPASVARVERVLESLDPDVLALELPAGALALYRAYARERDEKTGTPRFGGEMSAAIGAAPDAEVVGIDAPNWSFLRRVVTRLIADRVSPATARQVVANIGGATREVLACRVAATLTHATSMTVARNEPVEYDCSVDDPPERQAAHERAHVDTVQTLLESVDTDESALSYRDDVRERCMVDRLLECRTKGDVVAVVGVDHLERLEVDLTAQCRSVETQCQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMZ3</accession>
    <name>A0A3N6LMZ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86935">
        <property type="protein sequence ID" value="RQG86935"/>
        <property type="gene ID" value="EA462_14855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022430">
        <property type="entry name" value="CHP03684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="PTHR22798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03684">
        <property type="entry name" value="arCOG00985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="159" mass="17312" checksum="621EFD5DA6C331E7" modified="2019-02-13" version="1">MQVKSRHHLRSDAVSELEDTLSDQLGVTPDGDTYERVEFEDTDWEVILIDGEPQVSYFDEQPFLTVRGANAYEPSQRVVTVDSGAISFVSDGADVMRPGITEATDDIASDDLVLIAEESHGKVLAIGRARVDGADMVGDEGKVVDSLHHVGDDLYEFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP29</accession>
    <name>A0A3N6LP29_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91173">
        <property type="protein sequence ID" value="RQG91173"/>
        <property type="gene ID" value="EA462_04050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="93" mass="10395" checksum="33DC5941EEEE7C24" modified="2019-02-13" version="1">MELTNGESFVDETITLESGEETELEATDRFGTYNLSARTLTGHGTEEHGYRYSISDSTRHAYVTVAEEEVRVSHTESDLEPCSWDVTGSDFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP48</accession>
    <name>A0A3N6LP48_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91198">
        <property type="protein sequence ID" value="RQG91198"/>
        <property type="gene ID" value="EA462_04195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="290" mass="31137" checksum="0703E9E6571B0C27" modified="2019-02-13" version="1">MSIAHGPSMTIVAVLGVVAFAVAGAALVDVLESEPDAEALVADVIDDRETHVVEIEPAAGAPAGDGVSVLVGETEYVLGPDSEADASNASRTTTWWIDVEAGFPIKERIVTEHENPHEHVIERERTVRTVTYENVRFDEPIPDERFTFDPPDGTDIYEPAESDDVSTFAEAADAVPFPIAEPTPPEAFDLELVTANEFEGDATVQFLYRDGDELADDSLQGRITERPPTYDPEDVLEESVGDVDGSFVSTPMGTTLVWHCGDVRYELTPDVDGDEQALATTVAGSTGCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP84</accession>
    <name>A0A3N6LP84_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4336 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91228">
        <property type="protein sequence ID" value="RQG91228"/>
        <property type="gene ID" value="EA462_04350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="PTHR33835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="227" mass="25917" checksum="72502BAA14C5C36C" modified="2019-02-13" version="1">MLTRRGERFFTYEEPLRFFGVELGRIMSVIRLSSGGLFVQSPAELTPELKGALDELGEVRFVAATSKLHGHLYMEQYREAYPDVELLAAPGLAARRTDLRFDHLLGDVPDPRWSTDVDQVAIDGHRWLTEVAFFHRPSRTIVLGDLGFHIDESSPLKTRLVARGFRMYRRLSPPIEVRHTIANEATFRRSIRDVLAWEFDRVVPGHGTIIDSGGKRAVLEGYDWLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPL5</accession>
    <name>A0A3N6LPL5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_10445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88814">
        <property type="protein sequence ID" value="RQG88814"/>
        <property type="gene ID" value="EA462_10445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="143"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="266"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="401"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG88814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="597" mass="66237" checksum="62FE517E5AEAF6C3" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPQ3</accession>
    <name>A0A3N6LPQ3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="4">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dtdA</name>
        <name evidence="6" type="ORF">EA462_05790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DtdA deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91473">
        <property type="protein sequence ID" value="RQG91473"/>
        <property type="gene ID" value="EA462_05790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00562">
        <property type="entry name" value="Deacylase_DtdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018033">
        <property type="entry name" value="Deacylase_DtdA_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007508">
        <property type="entry name" value="DtdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34667">
        <property type="entry name" value="PTHR34667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04414">
        <property type="entry name" value="tRNA_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="462" mass="50138" checksum="6B5D6F66D0E2728C" modified="2019-02-13" version="1">MSDLAIVESRADRASVHICDELRDLVDWTERTDDGRPDADGGGTYYRTDRMELRSFDDFHLDLERPDSAFECDPDLLAFASRHSGDTGALLTGHFTGNFGPAEFGGDTNAVATACPNALVRLLETFDEHAPDGYDVGMECTHHGPTDVGCPSLFAELGSGDEQWDDPAGSRAVARAILKLRGVAPHRGRQVVGFGGNHYAPRFERIVRETPWAVGHVAADWALEAMDHPRTHEDLIEAAFEASNAEFALLDGEWPVLETTLEKLGYDVVSETWLREVGDRPLTLVATVETDLGTIDSGVRFGVRRETPVVVIDLPTELVEAAEGIDPDEVRGVIERNSIAFTTDNGGSRIGDRAAVPGTGSRDDVTNTDDAVDDGRGDDRTPRVAIVEELAAVLEEKYESVAITGDAVVVERRAFDPGLAREAGVPEGPKFGTLADGESVTVDGDTIEPERVWVRRTRTFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPZ7</accession>
    <name>A0A3N6LPZ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_06675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91628">
        <property type="protein sequence ID" value="RQG91628"/>
        <property type="gene ID" value="EA462_06675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAT" evidence="4">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="221" mass="25271" checksum="3B3709A8B096675A" modified="2019-02-13" version="1">MTLLAEFSISASNFSFGAVLADHDDLLIEFESVVPTHRGLMPFVFIWDGDEHDEIEAEIRSDPTIDRVDEVERFEDGRLYRVAWNDSVEGLASAIRESGATLIEAVGVDDRWTFEIRFRDQERIEQFQELVLEYDLELQLERLSTELEVDPGMEYDLTDKQYETLVTAFEYGFFENPKEVSLAELGAELDISDAAATGRLRRGMANLLSQTVMRREGTDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS40</accession>
    <name>A0A3N6LS40_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92673">
        <property type="protein sequence ID" value="RQG92673"/>
        <property type="gene ID" value="EA462_00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040493">
        <property type="entry name" value="DUF5518"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17647">
        <property type="entry name" value="DUF5518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="123" mass="11771" checksum="3CC0263CFB3310D0" modified="2019-02-13" version="1">MTDWRAVIIGFVVIVVLGIVGLTLPVVGQLAAGLVGGFVAGYLAGGGLGRGFWHGLLAGAFGGLVGGFLIAVAVGLIGWVGGPAGGLLTGVAGLGIFVVAVVVSFVMAVESAIAGAVGGVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSB5</accession>
    <name>A0A3N6LSB5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GimC subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">pfdA</name>
        <name evidence="8" type="ORF">EA462_09195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prefoldin alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90154">
        <property type="protein sequence ID" value="RQG90154"/>
        <property type="gene ID" value="EA462_09195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00308">
        <property type="entry name" value="PfdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PTHR12674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00293">
        <property type="entry name" value="TIGR00293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="149" mass="16511" checksum="F5516ADE2C4402B1" modified="2019-02-13" version="1">MSQQQLQQLSQEIQEIQQQIEAMQANVESVQQEKTEADEAIDALETLETGSTVQVPLGGGAYLRASIEDIDEAIVELGAEYAAEFEQDGAISVLENKKENLDDRIDEINEEIAELESESTELEQQAQQIQQQAMQQQMQGMGQGPSPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSP0</accession>
    <name>A0A3N6LSP0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_01850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92983">
        <property type="protein sequence ID" value="RQG92983"/>
        <property type="gene ID" value="EA462_01850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="146"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="222"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="277"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG92983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="488" mass="54813" checksum="CAD6DCF1C299F40D" modified="2019-02-13" version="1">MTRGNRSDDPGEIDSLGLPRPPFDEPDFFRQLVANTSEGLLTIDEGSTILFANPAIEEILGYAPEELVGRSKMTIIPERLRPAHAAGLEKYIRTGEKHIDWGGIELPALHRDGHEVPVLVSLREHRLSGRRVFTGLFRDISERKHRERRFEAVFNNTFQFTGLLEPDGTLIEANETAIEFAGIDRDDIVGKPIWETFWFQSNEQARAIAKEGVERARDGEFFRREVRIRGVDRTAIIDFSIRPMTDSQDDVQLLVLEGRDITDLKLREQHLQLLHRLLRHNLRNDLNVISGFAETLESELEHQKHAAYAAEIVAAARELIGMNETAKQLADATLSRDRIQRSIALDDVLVEVVSDLRDRYPSGTVSVTGRLESTVAADRRLHTVLSEILENAIVHARNDDPLVEISVAEFDETIGVVVADNGPGIPETERTGIFNEEPVTQMNHGSGLGLWLVELILDDYGGFLEYEPRSDGDGSRVTIHLPRPPTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSQ2</accession>
    <name>A0A3N6LSQ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cohesin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90354">
        <property type="protein sequence ID" value="RQG90354"/>
        <property type="gene ID" value="EA462_07665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="274" mass="27702" checksum="EE46EB1FA503B5D1" modified="2019-02-13" version="1">MLVVVLCGLAFGAVVPAPVIAGDSVTIIYVEESEIDADPGETIALEVMVSDHGDYDANGLGELSFDLTYDTDVFTATEVEHRSMLAAGDSDAEVIGSATIDDETGAVTIEQEREPPGDGAVATEPAATVTLEVAEDAPPTTETIGLTDGSAILVTDYPQSVFERDATVHVDGGDEESDGSGGEHDDADEPEGVTLADDAAVEDGDGTDGAEEADGSSANNGDASDETDDSDGETAAPSSGDDSTSDDPIPGFAIPAAIVGITAAIVGLVVRNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSY2</accession>
    <name>A0A3N6LSY2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SCO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_04615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91697">
        <property type="protein sequence ID" value="RQG91697"/>
        <property type="gene ID" value="EA462_04615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="58"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="274" mass="30811" checksum="304FB489B7D673B8" modified="2019-02-13" version="1">MERRTYLRGLGGVGIGGLAGCLDELGAGDESNPETEHWGDGETILDPPSEERGSTIHPIHGDEFPPFTLPDPLSDESVSLEDFVDERTFLMTYFFTACPDGACPALLLRLRRAQEDAIQEGYEDDIALLAMTFDPERDTPDVLESYAVERSIDYEADNWHFLRPESYEEGETLLDETFGMPIQRVEDPEDHEFEDEHDHGGDEESGDDHGDHDDEDQNGHADHDHGEYTFVHYNLIVLVNDQGVVERAYPNAVEQREEVSIETIVSDARTVAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT92</accession>
    <name>A0A3N6LT92_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">STAS/SEC14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93258">
        <property type="protein sequence ID" value="RQG93258"/>
        <property type="gene ID" value="EA462_03440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021866">
        <property type="entry name" value="SpoIIAA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038396">
        <property type="entry name" value="SpoIIAA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11964">
        <property type="entry name" value="SpoIIAA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="13779" checksum="C51B7072A54386EF" modified="2019-02-13" version="1">MVEKLPRSEGNRIGYEVNDKLSEEEYEEILAEVKDAIEEHGSAKLLIDLSGVSESYAEFDAYEEDLGFYLRHGEDMECYAVVGDDSVMKWGTEASDLVTDTDIEFFDEEDLDKAWEYVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LU96</accession>
    <name>A0A3N6LU96_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="5">HMG-CoA reductase</shortName>
            <ecNumber evidence="5">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hmgA</name>
        <name evidence="6" type="ORF">EA462_03770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-mevalonate + CoA + 2 NADP(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91124">
        <property type="protein sequence ID" value="RQG91124"/>
        <property type="gene ID" value="EA462_03770"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="4 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="408" mass="42075" checksum="18C40E6B43FCF5A7" modified="2019-02-13" version="1">MTDPDALADRVQDGELRLHELEDHADYDTAATARRLLVERETETELETISDYTFPAERAEPNVENMIGAAQVPLGVVGPVAVSGGAADGEHYLPLATTEGALLASVNRGLSVIRVAGGADARVTKTGMTRAPVFRVAGVVEASETVEWVEKNVDRLREAAESTTSHGELLGVEPYVVGDSVYLRFAYDTKDAMGMNMATIATGEACSIVERETPASLVALSGNLCSDKKPAAVNAVEGRGRSVTADVVIPGPLLEERLHTTADAIVEANTRKNLIGSAKAGSLGFNAHAANVVGAAFLATGQDEAQVVEGANAITTMDARDREDGASDLYASVSLASLEVGTVGGGTALPTQSEALEILGLRGGGDPAGSNADALAEIIAVGALAGELSLLAALASRHLASAHEDLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUE0</accession>
    <name>A0A3N6LUE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4129 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91184">
        <property type="protein sequence ID" value="RQG91184"/>
        <property type="gene ID" value="EA462_04115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="3">
        <location>
            <begin position="224"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="325" mass="34814" checksum="F7E25D1C95E6621F" modified="2019-02-13" version="1">MSRTRGAVRIVVALVGIAAIAMAAATIRSPTEPDGSGGVGEGDSGSPTGVPQHEPTDPAPLEVPAIVEYLAYALLILLALGAAWYLISHRRDLVKLIAVVLVVSLVLAGISYLLLRLDLWESVPLQESEPETNDSLGGEPGEGDDQQRQPFSTGPVLVVLAVLTAIFVGSLLRSDRDGRTKRNESEPGDGPSDASDSDRAEVGAAAGRAADRIESSDDFDNEVYRAWLEMTRPLEVDRPASSTPGEFATVAVDAGVRPEHVDELTSLFEEVRYGNRETTDDVESRAISVLRRIEDEYAEPTVSDVDGRDAIDPTKRDQDRSGVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVC5</accession>
    <name>A0A3N6LVC5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91634">
        <property type="protein sequence ID" value="RQG91634"/>
        <property type="gene ID" value="EA462_06715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="1">
        <location>
            <begin position="42"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="560" mass="62446" checksum="C6000D4FAF2D6039" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVD4</accession>
    <name>A0A3N6LVD4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Glutamyl-tRNA(Gln) amidotransferase subunit D</fullName>
            <shortName evidence="5">Glu-ADT subunit D</shortName>
            <ecNumber evidence="5 8">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gatD</name>
        <name evidence="13" type="ORF">EA462_06765</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 8">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the asparaginase 1 family. GatD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="5 8"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91644">
        <property type="protein sequence ID" value="RQG91644"/>
        <property type="gene ID" value="EA462_06765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08962">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00586">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011878">
        <property type="entry name" value="GatD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040918">
        <property type="entry name" value="GatD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037222">
        <property type="entry name" value="GatD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18195">
        <property type="entry name" value="GatD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500175">
        <property type="entry name" value="Glu_ADT_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141300">
        <property type="entry name" value="SSF141300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02153">
        <property type="entry name" value="gatD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatD_N" evidence="12">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase" evidence="10">
        <location>
            <begin position="83"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="11">
        <location>
            <begin position="311"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG91644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="434" mass="46306" checksum="EBB1196EEB71776C" modified="2019-02-13" version="1">MNPGDRVRVDRADRTYEGVLLPSSTDDHLVVKLDGGYNVGVDRDGTDVDVLAEDVYEIDGTDAAGTDADGTSEIAFDDELPTISLLSTGGTIASTVDYRTGAVTAQFDAEDVLRAVPDLAGRANYRGRVVANILSENMDPTIWSDLAEAVSEEIDAGADGVVVMHGTDTMQYSASALAFTLETPVPIVFTGSQRSADRPSSDNVMNAVCAVEAAKGDCAEVLVCMHGSESDDVCALHRGTRVRKNHTSRRDAFETVGAKPLGAVDYDTGEISFRREYRSRVDGDTSSDGSDDRASEPRDSPIAIESLESDVELLKFTPGMDPAFFDVVEGSAGLVLEGTGLGHVHTDLIPRIEELIADGTTVVMTSQCLEGRVCDRVYDTGRDLLDAGVIEAGDTLPGTAKVKLMWALENADDVEAAMETSLAGELQRRSVPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LW46</accession>
    <name>A0A3N6LW46_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">ilvC</name>
        <name evidence="12" type="ORF">EA462_02150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93037">
        <property type="protein sequence ID" value="RQG93037"/>
        <property type="gene ID" value="EA462_02150"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="7"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="187"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG93037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="350" mass="38564" checksum="F8EF3CF8355B60B6" modified="2019-02-13" version="1">MTDEFTTDIYYDDDVDGSYLATTTVAVLGYGSQGHAHALNLHESGVDVVVGLREDSASRAAAEEDGLTVTTPVEAAARAEVVSVLVPDTVQPAVYERIEPELEEGNTLQFAHGFNIHYNQIQPPEHVDVTMIAPKSPGHLVRRNYENDEGTPGLLAVYQDYTGDARERALAYGKGIGCTRAGVVETSFKEETETDIFGEQAVLCGGIAELIKVGYETLIDAGYSPEMAYFECMNEMKLIVDLMYEGGLGAMWDSVSDTAEYGGLTRGDDVIDDHVRENMEEVLEQVQNGEFATEWIAENQANRPVYTQLNQAEKDHDIERVGERLRALFAWEEATEGTEDEDQTRVTATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXZ7</accession>
    <name>A0A3N6LXZ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86158">
        <property type="protein sequence ID" value="RQG86158"/>
        <property type="gene ID" value="EA462_16940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="186" mass="19841" checksum="DEAD34AD4C488FC0" modified="2019-02-13" version="1">MPETEQQDKTLSELVVKEAIGKGLDTPLRESILEAVDESEAGGSDSRVPLAGALFGLGAAVGFLAGRHSPSLEETPLEDLDETELIDVDESDDERPLEVGSEETDEAEEEGSSSRLARLVLVLGAIAGIALLRRRLGDDEDDWEPIEEFEPATSIDADEGAEATDENEADADDSDDLESDLGADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY26</accession>
    <name>A0A3N6LY26_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86991">
        <property type="protein sequence ID" value="RQG86991"/>
        <property type="gene ID" value="EA462_15200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="68" mass="7673" checksum="39903DBE2B08634C" modified="2019-02-13" version="1">MALIVDRTAERDCSTESKPTLEDESQRERIDVTDLRAAGIEEFVRSSVETDAVSLENRGARTYLVLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYC2</accession>
    <name>A0A3N6LYC2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_01115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92854">
        <property type="protein sequence ID" value="RQG92854"/>
        <property type="gene ID" value="EA462_01115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="361" mass="38751" checksum="82F443B7F2F21CF1" modified="2019-02-13" version="1">MALLEVENLTVQFYTDDGVVRAVDGLSYEIERGETFGLVGESGAGKSVASRALLRLIDSPGEIVDGTIRVGGRDLLEHSDEELRARRGNDVAMVFQDPNATLNPVYTIGEQITETIRAHGVATGSDARTRALSLLDRVGIPDPAGRYSAYPHELSGGLAQRAVIAMALSCDPDLLILDEPTTGLDVTIQAQILALLDELTETFGTAVQLVTHDLGVVAECCDEVLVLYAGQAVERASVEELFYDPAHPYTAGLMASIPRIGQEVDRLSTVPGAMADPVHPPTGCRFHPRCPYAEPICETRGTELVGTETGDPVSRTPENEHVAACHEYTGELDGGLEYEVRIDDGRRNESAGAENVESKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYD2</accession>
    <name>A0A3N6LYD2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphonate ABC transporter, permease protein PhnE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phnE</name>
        <name evidence="6" type="ORF">EA462_16485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86732">
        <property type="protein sequence ID" value="RQG86732"/>
        <property type="gene ID" value="EA462_16485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005769">
        <property type="entry name" value="PhnE/PtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01097">
        <property type="entry name" value="PhnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="87"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="278" mass="30429" checksum="66A3B015031BB650" modified="2019-02-13" version="1">MSESSTPHNAGQQDDSRKHREWNRFSLRQRLTRFLSLAVSLIVVIVSWRFLDMNFYYMWTASATIQDLLGRMFPPDIGYTHEIMGPLIETINMAIVGTILAILLALPVAFLAARNTTPNKITYGLGKFIISFTRSVNVIIWALIFVVVFGPGALSGVLALAMRSIGFVSKLLAEAIEEIDPNQVEAIAATGGSSFDILVYGIVPQIKPAFIGVATYRWDINVRAATILGLVGAGGIGVQLNTSVNYFNWDAVLTILIAILVIVAISEVVSAYFRSKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYS5</accession>
    <name>A0A3N6LYS5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PstS family phosphate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93024">
        <property type="protein sequence ID" value="RQG93024"/>
        <property type="gene ID" value="EA462_02085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="49"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="349" mass="37983" checksum="4E1C9206004D0A74" modified="2019-02-13" version="1">MTDNQSGRPDFGGVSRRNFLAGGTTVAAMSVAGCGDVLGDGNGDGGGPSGTIDASGSNTVAPITSWAGEQFENEYPDVLVDVAPEGTGAGFQEFCRANSAVQSASREITEDEVDLCEENDVDYDFLEVGLDGLSVVKNSENDWVDNVTLEELQLIWEFEATDEITHWSDVREEWPDEEIQLHARDSASGTFDYFTREINGEIGDVRDDYSATSQTNEIMGAVADNLHGFGWGGLGYLREIEDDQPIEAVPVESDADGEFYLPTEQNIEDGLYSPLARPLFAYVNLASLEEQTDLIGSFARFYTNGAQEFAREEGFYAAPDAVTDENHDKIDGWLDRVGSSPDGITVQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYV3</accession>
    <name>A0A3N6LYV3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93054">
        <property type="protein sequence ID" value="RQG93054"/>
        <property type="gene ID" value="EA462_02265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="408" mass="46997" checksum="2111C4A05AF63EBA" modified="2019-02-13" version="1">MFIVVAQRLRPMIGVSVSLYDKFEDLGVLLDIVRNNWEDEYFVSVCSNHPNAHEKVSDLSSEIDHFEQGAQIDADESIAGRSKRVNFLLRVNNTIRTAIRGALSCDEVDHVLHLHSDAWPLSEEGLQSLIDSMDERDASVAFKTSTEKFLEQYPPGHFMDQFLLFNATDCRSAGLFERELLEYPPGIHSHRLLPMVCLVAFGWGSIWHYSNRSEEVLWDGEPTLRAGRRVRPMTYNPKYAQVHIAREDFGPGQGKSLQAYYLDEHGLTEGEYIDELLTDHLRDRDTLFDDIAGYYAQFDEELKWYYGVSTSSLGRSTRDIVEFTDLDGREKMMKVLGHNVDVLANGVYDRFQQLMGDSSPDIRTERKTKELDLHKHYTQALNKDTLPEDLRGKHFMNTYNTRHHPNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYW1</accession>
    <name>A0A3N6LYW1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87883">
        <property type="protein sequence ID" value="RQG87883"/>
        <property type="gene ID" value="EA462_13550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="9"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="347" mass="38329" checksum="A6E96F590515DA05" modified="2019-02-13" version="1">MNGGSDPTIDAYSHVVPSEYKTALESYTGSSYTISDLHDAIPTLTDVERRLTTMDECGVDVDVLVPASPAVETVADHRGAVELARTMNDGIARIVDEYPDRFAGVATVPMNNPEAMVDELERAVTDLGLCGALIYSNVDRRPADEPHLDGAGRPIDGPEFDPFYEMAAALDVPLWLHPARPKTTPEYVGEPTSKYLVWQMFGWPFELSAAMARMVFGGVFDRHPELDVIAHHAGGMIPLLTGRMDVHYDLFETFSGTDLTDHLSSPYSDQFRRFYVDTATFGSVRALEMAIEFFGVDHVLFGTDAPFDTSEGRRCRNRCRKALDAADLSERDRQRISGGNVRTLIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZW6</accession>
    <name>A0A3N6LZW6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88870">
        <property type="protein sequence ID" value="RQG88870"/>
        <property type="gene ID" value="EA462_10750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="76" mass="8667" checksum="8661774D0B447D2C" modified="2019-02-13" version="1">MRPWFIIPDGALFKQSEATRSAEKRARMGFESENTQPIEARSCDRGSNPGRCIRPRNGVTKGEPTLWAPMTNEPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M009</accession>
    <name>A0A3N6M009_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3311 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88920">
        <property type="protein sequence ID" value="RQG88920"/>
        <property type="gene ID" value="EA462_11030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021741">
        <property type="entry name" value="DUF3311"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11755">
        <property type="entry name" value="DUF3311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="92" mass="10223" checksum="EAFE1C98938B1009" modified="2019-02-13" version="1">MPRGELGGWVAIGITLSALAIPWFLWGSDAVVAGFPLWLWWHIAWMVIASVVFWLFARRAWGIGIEPESTPDDSRAEDGTRPSRSDAGGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0V1</accession>
    <name>A0A3N6M0V1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89290">
        <property type="protein sequence ID" value="RQG89290"/>
        <property type="gene ID" value="EA462_12035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="116" mass="12135" checksum="01C67458BCD2AB21" modified="2019-02-13" version="1">MVPIIGSVVAFVVALLVGGLAIYVSACLVLDVEDYSHAVVTALFGAIAWALTAWIPLFGSLIALVAWVWVINWRYPGGWVNAAIIGAVAWFAAFAILFVLNSLFGLGVNAFGVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M164</accession>
    <name>A0A3N6M164_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88811">
        <property type="protein sequence ID" value="RQG88811"/>
        <property type="gene ID" value="EA462_10425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="759" mass="84059" checksum="F43038FEC79F6C8B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1E5</accession>
    <name>A0A3N6M1E5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminopeptidase P family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_10985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88911">
        <property type="protein sequence ID" value="RQG88911"/>
        <property type="gene ID" value="EA462_10985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="162"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="396" mass="42389" checksum="EBD0F1B6EBF0BDE4" modified="2019-02-13" version="1">MEFTADLSALIDVLDSDDVDGYLIDDDSTDSDQRYVSGFTAPDAYQTLVTPDGGVHLLVSGLEYGRATAESNADSVTRRASYDYQGLAVEHGPHEGKIRMLETFLDDHDVASVSVPRSFPTGTADGLRDRDVSVTVEPESIVEGIRATKTDWEIDQIEATQRANEAAMATAEALIASADVEDGVLVHDGEVLTSERVTEEIEITLLRNGCQLDETIVACGADGADPHDRGSGPLEANELIVIDIFPRDKETGYFGDMTRTFARGDPGEEARRRYEVTERAYEAALEAVEPGVTGAEVHDVACDVIEEAGYETLRSDPSTDTGFIHGTGHGVGLDIHEQPTVSPGGGELEPGHVLTIEPGIYDPAVGGVRIEDLVVVTEGGSENLTEYPVALEPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2B9</accession>
    <name>A0A3N6M2B9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89271">
        <property type="protein sequence ID" value="RQG89271"/>
        <property type="gene ID" value="EA462_11070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="223" mass="24451" checksum="10F139D009CBD520" modified="2019-02-13" version="1">MAAYDAICFDLDNTLCEPTQDASSVLEATFERAGLEQFCTAADLRNAVPALPTAETDREFYEHLFSEVASRANVDPVVSSRLTDWYLEIRNPTAVRFRPGAREALDYARDRGPVALITNGGRRTQTKKLRALEIEGEFDVRVFTEPSAGIYPKPDAAPFEYALSELGAEPRRSIHVGDSLHADVAGANAMGLDSAWVDTGRGRNGDHQPTYELSTLEALETIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2Q5</accession>
    <name>A0A3N6M2Q5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-ribbon domain-containing OB-fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90100">
        <property type="protein sequence ID" value="RQG90100"/>
        <property type="gene ID" value="EA462_08875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="135" mass="14433" checksum="CCEBEB4AE3C73283" modified="2019-02-13" version="1">MSDSGESEGVQDAGFDDWVDAAEEGTAYYLECPDGHGSLPPRRVCPECGLTDLERVDVPETGTVETYTVTHVPTPAFEDDAPYATAIADFGPVRITGQVVGTDPDVVEDGLEVELEITVSQTTGERVIGFDPLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M311</accession>
    <name>A0A3N6M311_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90220">
        <property type="protein sequence ID" value="RQG90220"/>
        <property type="gene ID" value="EA462_09555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="101" mass="10795" checksum="5CE929BB3B5087B3" modified="2019-02-13" version="1">MERGGNDVDERTQRSASHAVVEAVASAEGVPTDALCPPEYEPLNSVIDPDALDSLFADRPDGRHRSGGTVSFVYCGYRILVEPNGSVTVEPRSGLEGFEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M469</accession>
    <name>A0A3N6M469_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aromatic amino acid lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86947">
        <property type="protein sequence ID" value="RQG86947"/>
        <property type="gene ID" value="EA462_14920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="498" mass="52954" checksum="56AC4CA2019D6FAD" modified="2019-02-13" version="1">MIELTGTLSTQDIVAIARGNAAVSLPTEAVERMERTRAIVDDVVRRDDYHVYGVNAGVGDLHEKSISRDRILEMQENIIESSITGVEPLASTEITRAAMATKANTFATGRSGARPELVQKLCAMLNEGVHPRLYLGGSTDDLTAIAHVGLVLLGKGTAELDGEVVSGGEALERADIDPVQLAPKEAMSIVSGTSVMTGMLSLCVRDVDRLVRTADIVSALTFELIGDAPETFASRVSDVRPHDGHATTATNVRTLLDGNVDGSSPKMVQDPLSLRVIPQVHGTVRSHLSFARETVDTELRSASDNPLVFPDGKLYSCGTFNGQPISSAADSLRSVVIKLGSISESRNERLLQNRQTDYPFLAADPGVESGLMMTQYTSSGLLAETLATDGVSTSSVTVSGGQEDIHSMGTISVRALADTVETVGRILAIELLCANRYHNLVGDISTTTALEELLEYVNAIVQDPIEDEPAFDHIASLTEAVLSGTIVDVVESTGVDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4L5</accession>
    <name>A0A3N6M4L5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_15885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87107">
        <property type="protein sequence ID" value="RQG87107"/>
        <property type="gene ID" value="EA462_15885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="136"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="507" mass="53020" checksum="830DF166BE4D23F2" modified="2019-02-13" version="1">MALVELPEWVALAPILLLAGTALALFVFDSINPRSTNRTFLAGTAAIGSLASLAVAVWFTAAGVGATGMDGFGVIELFDGQIVVDQMALFFMVVIAVVTALVAVASYDYMEGHAYQAEYYSLVLLAATGMATMAAANSLVTIFIALELASLPSYALVAILKDNRGSVEAGLKYFLIGALSSAIFVYGVSLVYGATGFMQLDAIAAELEALAAGEGGEYGGLLGLGILMLIGGFAFKTASVPFHFWAPEAYEGAPAPISAFLSSASKAAGFVIAFRVFTTAFPLEVTTDLIGIDWTLAFIILAIVTMTVGNFAAATQNNVKRMLAYSSIGHAGYALIGLAGLGAGSETVMGAAMMHLLVYGFMNTGAFLFVALAEYWNVGRTFEDYNGLARQAPIACVALTIFMFSLAGIPPFGGFWSKYFLFYGAIEAGLLVVAAALVINSALSLYYYSRLVKAVWFDDPLVERDSLSQPTGLYAAIIFAAVMTVVLLPGFGPVVDAALEAAAVVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M517</accession>
    <name>A0A3N6M517_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87779">
        <property type="protein sequence ID" value="RQG87779"/>
        <property type="gene ID" value="EA462_12965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="70" mass="7565" checksum="DAA3E9EBA125A536" modified="2019-02-13" version="1">MAVVQRVATATDRPATQLPPLYDAIDPEALDAVFRSGSTGSSEIAIEFRYAGYRVTIDSTGQIEMEQASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5H4</accession>
    <name>A0A3N6M5H4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87979">
        <property type="protein sequence ID" value="RQG87979"/>
        <property type="gene ID" value="EA462_14065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="150"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="281" mass="30889" checksum="0B32B97CF7C8D429" modified="2019-02-13" version="1">MKAVCATDLSAASEATIESETCLECLGRVGVDEMHLVTVIPSNVHAGMPGMDFEGRRQRALERYRGVIESAGFDVETHVVRGTPHRRITGIATTVGAGITIVGSRGKSPLENRVIGSTARNLARTTETPLLVNRIEREAENPDVVREHLFQRMLYATDFSENADRAFEAFSYLRHATRETTLIHVETPKDPGLREGENPENRLGELAAQLEEWGIETRTELRRGDPADEILGAETTYEPTAILVGSRGHSRLRRLLLGSVSEDIVARADSNVLLIPPSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5I9</accession>
    <name>A0A3N6M5I9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87999">
        <property type="protein sequence ID" value="RQG87999"/>
        <property type="gene ID" value="EA462_14170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="273"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="474" mass="52658" checksum="5BD8D3ED8C1BB6EA" modified="2019-02-13" version="1">MTQEHQTEPADEFELEHFERNRYFQGKLMTAHDMSTEQKYHASRLETVTRLVTGTGIVSGLSIIDFDYEDGELHVTIGPGVAIDGDGRPIVVRTPTTRTIPTGDGNYVSLYITYDEESKDPVPVPGVEATDGEESQESRVLEIFELVATETPPNSRKTPPLVDLPDLDNADEYSTLADHIVDSYHEAHRERAASSANPGVFLGAFERLPDGEWQVDDDETKRHPFVYDNDMLFSLFLSLLVATDGAHGGDERRPGVEYLESELDQLGQFANQIQGLELDVSELRTAIDETEDTVRTEFQDALESTETELRTEIETAENDLYESIESTRAALRSDVEQLQDALQTQAELNAYQSLKMAIRCFDDAAATFDHQGAVSKLSLGVVEAAREAIAEEADRDAAEYRAFVSSVTDDLESLTGVLERAATDESYNQFARTVSSLEDVRTDDGSFVELVAAFDRVCQTATLLEPQYEIQPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6J4</accession>
    <name>A0A3N6M6J4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88936">
        <property type="protein sequence ID" value="RQG88936"/>
        <property type="gene ID" value="EA462_11125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="235" mass="26427" checksum="D1F0DA79480124F2" modified="2019-02-13" version="1">MKGQEWYQADDVAEEYDDKRFSRGGQLIDHREKRAVLEAIMPVEDRSVLEIACGTGRFTVMLAEQGADVVGLDISAAMLQQGRAKTRGSNLSGTLEFLRGDAGRLPFPDDHFDTVIAMRFFHLADDPEAFLREMRRVSRDQIVFDTFNRFSARSVYNWALPMGSRLYSKSEVTTLLAKTDLTLVDVVDDFLVPYGLYRAIPNALATPIRTLDTAIGGHSIPDHFASVSYWNVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M729</accession>
    <name>A0A3N6M729_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91141">
        <property type="protein sequence ID" value="RQG91141"/>
        <property type="gene ID" value="EA462_03860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="66" mass="7639" checksum="3F98EC661F3AC08B" modified="2019-02-13" version="1">MATTDDSFNGMTERCDSCELETIHEVSVQIRTESMKEENAQFSREPYRVSECQRCGNRTSQRMNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7M5</accession>
    <name>A0A3N6M7M5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl23</name>
        <name evidence="8" type="ORF">EA462_05035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Contacts protein L29.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91341">
        <property type="protein sequence ID" value="RQG91341"/>
        <property type="gene ID" value="EA462_05035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_L23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_L23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="84" mass="9411" checksum="7E489937E0E4E787" modified="2019-02-13" version="1">MSSIIEHPLVTEKAMNDMDFENKLQFVVNPDATKPEIRDVVESRFDVGVDSINTQLTMKGKKKAIVKLSEDDDAQEVASRIGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7S2</accession>
    <name>A0A3N6M7S2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91391">
        <property type="protein sequence ID" value="RQG91391"/>
        <property type="gene ID" value="EA462_05305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="198" mass="21708" checksum="B9CBC2A8CDCDE540" modified="2019-02-13" version="1">MSSDVTPGSSAGRSLLNDVPVDHYEILRHPRRVRLLEIIEDRPRVTLEELTTTLIERGGTDVPVGTARREVHLSLVHNHLPRLVDAGIVEWDDERGVALVENPPVCPERLSRVLKNDTQRLECLTDPVRLRLLDVLNGHAGSLSLEALASTLAANGIIERSDADTVTAALHHSHLPALDDAGLLEYDPESGLVRSIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M999</accession>
    <name>A0A3N6M999_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_08790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90086">
        <property type="protein sequence ID" value="RQG90086"/>
        <property type="gene ID" value="EA462_08790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="231"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="283"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG90086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="994" mass="107903" checksum="71CB61104630DBEF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9H3</accession>
    <name>A0A3N6M9H3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Patched family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_09310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90176">
        <property type="protein sequence ID" value="RQG90176"/>
        <property type="gene ID" value="EA462_09310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="872"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="897"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="928"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="970"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="438"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="867"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="127"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG90176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1081" mass="115714" checksum="F16F85C0E535FACF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9L4</accession>
    <name>A0A3N6M9L4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NMD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92980">
        <property type="protein sequence ID" value="RQG92980"/>
        <property type="gene ID" value="EA462_01835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="PTHR12746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMD3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="381" mass="41570" checksum="1ED3620E7853A52E" modified="2019-02-13" version="1">MSESRAFCPRCGDPVAERSADEATAEGDDVASDPLRPGSEVELCDSCYFDDFDFVDAPDRIDVRVCARCGAVHRGRRWVDVGAEDYTDVAIDEVSDALAVHVDVADVAWQVEPEQVDENTIRMHCYFTGVVRGTPVDEEATVLVRIARQTCTRCGRIAGDYYASIVQIRAEGRTPASEETDRAKEIAHEIVADMVATGDRNAFVTEISEVDDGLNIKVSTNKIGKKIANKTVEEFGGTVTDAETLVTEDEDGNEVYRVTFAVRLPPYTSGDVIDLENDDGGPVLVRSARGNLKGVRVTTGERYEASYEEGTSPDARALGTRDDADETTVVTVEDENAVQILDPETYRATTVSRPDYFDPGSETVPVLKSRAGLHILPDDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9M1</accession>
    <name>A0A3N6M9M1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90226">
        <property type="protein sequence ID" value="RQG90226"/>
        <property type="gene ID" value="EA462_09585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="269" mass="30353" checksum="AEF8901FC9653C15" modified="2019-02-13" version="1">MDIRQLARGTVEWERIERVVRSLADRHDRDVVRVEFLEADNWLSTPCVIDDEWFVKIVSRQNALVHALLTTGRNVGAVSSGTGGFFDRFDTPREMVEHEYEATERMRSIGVNAPRPIEAFEVNGLGVLVLEYLPEFESLESVSDSVVEQRSPELFEMLSSLHENGLAHGDLRAENILFCDGELYFIDATSVHEDRVSETTAYDLACALAVLEPRIGPRAAVQAASSAYGPSELLSARRFLDFVRLRPDHEFDSTRLRSELEKAADLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBU3</accession>
    <name>A0A3N6MBU3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="9">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EA462_03890</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91146">
        <property type="protein sequence ID" value="RQG91146"/>
        <property type="gene ID" value="EA462_03890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 9" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_lgN" evidence="11">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="175"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="966"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG91146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1045" mass="115008" checksum="6DEA569358D6EFA6" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCL7</accession>
    <name>A0A3N6MCL7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93241">
        <property type="protein sequence ID" value="RQG93241"/>
        <property type="gene ID" value="EA462_03345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="69"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="232"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="283" mass="31015" checksum="9A82F4F5B4F4EEAE" modified="2019-02-13" version="1">MNVADAMTARADVVTVELPGTRADVLEYLQERSFSSVPVVKPTDDGPEYRGLVSRDALIEQPDEDQLVMLMDEVPTTTSETSLEDAARTMVQEDARRVPVVDGELEGIVTVTDVIHAIATGDQETDATAESYASDDVNTTYEGTPLPVSERELYYANVPYTVALDDDGRMSGVLTEVDIIDVARIVEGEEETGNNFPDQDSQWSWEGIKGVGSRYLPTRDIELPNGPVSEFMTDDVVTVSASTSLQEVAQRMIRNDIEQIPMVTGEQLVGIVCDVNVLETLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCM8</accession>
    <name>A0A3N6MCM8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91496">
        <property type="protein sequence ID" value="RQG91496"/>
        <property type="gene ID" value="EA462_05915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="156" mass="18107" checksum="8180BAC858EE53CF" modified="2019-02-13" version="1">MGLEVEPPAPPELEFVDPNEYDDATISADGADEIDYRREELQEFLETGAWDDALAEWLEDTDLDENEYAIARDLDLFAEFDFFWDDFADRVGYHAPGIPEDWQTREYHPDLETWGTVSAINAELTEFGQIVSVVLKEEYIDWEAEYEPPDDLPDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MG27</accession>
    <name>A0A3N6MG27_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92876">
        <property type="protein sequence ID" value="RQG92876"/>
        <property type="gene ID" value="EA462_01235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="35"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="274" mass="30117" checksum="EE04BDD7F9B0EAD5" modified="2019-02-13" version="1">MRVTLLGTGDTTGTPTVGCDCETCEQARERGLERTRFSVHVENERTDESLLIDFSPDFRYQFLRDEVSLPDAAVVTHIHFDHLDGLGNVFRLLDSLEVYAANETDSVTGESVAETIESKYDYLDAVTVRPTTPHESVRVCGFDLTLVPVEHPPFVCYGVAIEDPMTGTKLSLTGDTSFGISDRSRAVLADPDLLLADAIVPASLCEYHPLGGRHVDDDDVPRTFGTKHMTREGALGLADELNASETRLVHLAHFYPADEAFDEPLAIDGETYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGV8</accession>
    <name>A0A3N6MGV8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_03210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93216">
        <property type="protein sequence ID" value="RQG93216"/>
        <property type="gene ID" value="EA462_03210"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="260"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="336"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG93216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="392" mass="42112" checksum="8B44674C5B3CEB4E" modified="2019-02-13" version="1">MRVVAKFGGTSLGSGERINRAADSVAAAVEDGHEIAVVASAMGSTTDDLLDDITFETDEADRAQIVSMGERTSVRMLKAALSARGIDAKFLEPGKEGWPVVTDEYGEVNVEESQKRALEVSETMDEEVPVLTGFLAEGPDGAITTLGRGGSDTTAVMMGKYMDADEVVIVTDVEGVMTGDPRVVEGARNVGKISVDELRNLSFRGAEVVAPSALSYKDGRLNVRVVHYQHGDLLSGGTSIEGEFKSLVGLRERPLACLTVAGRAIRNQPGIFHHLSEALSESDINIDAVASGMDTITFYIDEDEAERAENILHREVIARDELSSVTVSSPIAVVRVTGGELPNRPGVVSEIINPLAKERIHLKDVITSATSVALFVDWDDREKTLELTQDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGW4</accession>
    <name>A0A3N6MGW4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93226">
        <property type="protein sequence ID" value="RQG93226"/>
        <property type="gene ID" value="EA462_03260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="192" mass="21507" checksum="2E956E886BDF4DF2" modified="2019-02-13" version="1">MDYRLEIEGTPATISGGTGVLLLHPSTGETDRIDTDFLKTDTDHFLVVSTRTTAREAKQKLEYYDVDEERAEILDTLSIERGYSRRTSDTVHYVAAPDDVDAIVEHIDGFLDAYDGKLRLSFDSITELAYYAGDDDALETVDRILELLASYDAVGLFHVSEEPHDASLVEEFRKRFDGVIDLDEDGSVDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MQM1</accession>
    <name>A0A3N6MQM1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">mutS</name>
        <name evidence="12" type="ORF">EA462_17305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86119">
        <property type="protein sequence ID" value="RQG86119"/>
        <property type="gene ID" value="EA462_17305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="11">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="824"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="497"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="617"/>
            <end position="624"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG86119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="893" mass="97215" checksum="50E8E013FC4812BF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRA0</accession>
    <name>A0A3N6MRA0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_16750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86783">
        <property type="protein sequence ID" value="RQG86783"/>
        <property type="gene ID" value="EA462_16750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="4">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="89"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="534"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="652" mass="72800" checksum="F7C2A1063ED1D925" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRS2</accession>
    <name>A0A3N6MRS2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86973">
        <property type="protein sequence ID" value="RQG86973"/>
        <property type="gene ID" value="EA462_15075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="154" mass="17956" checksum="3F8C5A276BD86855" modified="2019-02-13" version="1">MVVFLANRANLQSKRLHDRIQNRLSGEFENVRRRRAEPREAGPYRVVAEVDPRQFLGDDEYPVATARVEIGFRLQTGEPHEYYWFNWIEPERSLLVGWHQDDTHDNLGPVHLQVNDGATPIAHEPAQFIDSHPLDVIERRLNSLRDAVLAVEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRU6</accession>
    <name>A0A3N6MRU6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87003">
        <property type="protein sequence ID" value="RQG87003"/>
        <property type="gene ID" value="EA462_15270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="354" mass="39895" checksum="C784D08BD3AFB141" modified="2019-02-13" version="1">MRETLAEWRPAVDEALADLVPREIDAEYLETFFGEPTYEYDPDGIQRALSDPLWDLLDRGGKRWRAVLFLVLVEGFGADPMEYLPYACIPEILHNGTIIVDDVEDEAAKRRGEPALHHLYGQDVALNAGNAMYFLPLKILTENPADLPDDRRLAAYEMLMYELNRTHLGQGMDICWHNEREVRITPAEYLEMCACKTGCLGRIVARLAAIITDQPDDVEETVANYAELTAVAFQIGDDILDVENSLGRAGEFGKEFGNDVREGKKTLLVIHAIEESAPENALRLEEILEADANTDEEVLEALTIIENAGSIEYARNRALELAAQARTEATELEFDEETTRKLTEFTRFVIDRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MT09</accession>
    <name>A0A3N6MT09_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87915">
        <property type="protein sequence ID" value="RQG87915"/>
        <property type="gene ID" value="EA462_13715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="438" mass="45801" checksum="37EC0003C30BBEFF" modified="2019-02-13" version="1">MTEQVLRTLMRTVDMIVAGFFSPAAVAAVGLADIYARLPLWIGLGTGDAAIALSSQDTGSGATANRNEAVTQALLLGALTGIPFVLFGLLLNEWAIGVLGAESEVVALGAAYLAIILVSSPARHVVLISARSIQGTGDTLTPMYVNGATNVLNISLTIVLAFGIGPAPELSVIGIAAATAAADVLSAIAFLAVIASPRCELEFALPRQWIIAKQLVVIGTPRVAEGLTELVAEFPFNAILLVFGTEVNAAYHIGRRMYQQVADPLARGYSVTANILVGQAVGRGEHDVAYFNGWSTASLAVLTIGGLSAALFVGAEQFVLLFTRDPATVEYAASFAQAYALAAVFIALFESVSGALRGGSETRSPFAAKLTGTFGMLLGVTYVFGIQLEYGVVAAYVAIVADFLWRNVVVCTTFVRQSWLERGATMMSERGSAPADED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTZ6</accession>
    <name>A0A3N6MTZ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88852">
        <property type="protein sequence ID" value="RQG88852"/>
        <property type="gene ID" value="EA462_10655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="7424" checksum="05130A7C98B832E3" modified="2019-02-13" version="1">MASLAARSSRLTSTRVREVTFLEDLYATQSTAVEMFQVLRLLWMSSMWIGVLPRNPFRLVDDQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MZY6</accession>
    <name>A0A3N6MZY6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91182">
        <property type="protein sequence ID" value="RQG91182"/>
        <property type="gene ID" value="EA462_04105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="178" mass="17781" checksum="1218BA73B90308D8" modified="2019-02-13" version="1">MTDPTGSRVEITRRPTLVASGGAIAAVALATVIVALTSTTAGALALVGLVSLLAGVGAEQPFNRDLVVDLGSLAAFAGVIVAGLEGSSIELTLLATVCVVVAWDLAGSAVDLGRQLGREADTRRLEIVQTVSSLLIGLTTVTIGYGVYAVAASGQPVGALVLLLLAGTFATLALGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N051</accession>
    <name>A0A3N6N051_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91242">
        <property type="protein sequence ID" value="RQG91242"/>
        <property type="gene ID" value="EA462_04425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="356" mass="39001" checksum="29DABC89D85B151D" modified="2019-02-13" version="1">MSTERTPLTSLPVRVGVIGVGAMGKNHARIYSELRDVDLVGVTDRDTDAATRVAGEYGTESLALERLLERCDAVSVAVPTHVHADVVSRCFEAGVHVLVEKPIAETIEEGREMAAHARDAGLLLQVGHIERFNPAVRTVSELIDDLDVISLEAERLGPPTDRSALGNVVFDLMVHDVDIVGAILGAEPDSISAMGTGDGKYATATVEYDDVVARLTASRVTQKKVRKLTVTARECLVEVDYLEQSVLIHRDSYPEYLIDDGQRRYRHESVVERPRVDNGEPLRHELESFLEAARTGSEPVVTAQDGIDALETVQRIDGIVSDDGHSDEEGQAQQREQDGAQPDHESDQEREQEVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0K1</accession>
    <name>A0A3N6N0K1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase MptA</fullName>
            <ecNumber evidence="3">3.5.4.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GTP cyclohydrolase IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mptA</name>
        <name evidence="4" type="ORF">EA462_05525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58854"/>
            <dbReference type="EC" id="3.5.4.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP cyclohydrolase IV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.39" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91432">
        <property type="protein sequence ID" value="RQG91432"/>
        <property type="gene ID" value="EA462_05525"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00065"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003933">
        <property type="term" value="F:GTP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01527_A">
        <property type="entry name" value="GTP_cyclohydrol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003801">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2/MptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022840">
        <property type="entry name" value="GTP_cyclohydrolase_MptA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36445">
        <property type="entry name" value="PTHR36445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02649">
        <property type="entry name" value="GCHY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00294">
        <property type="entry name" value="TIGR00294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="May be catalytically important" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="313" mass="34430" checksum="079D6E990164A347" modified="2019-02-13" version="1">MSHQLPDVQASSPDVTVGLSQVGVTGVEKLVKIAREGKRPLVFTAEFEVFVDLPAWRKGADMSRNMEVIDEILEDATREEAYHVEEVCGDAAERLLGKHEYTSKATVSMEAEFMRREETPATDRETQHTVDIVASATATDEGTREEIGATVTGMTVCPCSQGMSAARAKATLEDLDVDDETITQFLEEVPQPGHSQRGHATLTVESGGDPDVDLNDVIDIARDAMSARIYNLAKRPDEDHMTFEAHSDAKFVEDCVRSMAEGVVSQFGHLPDDAVVTMKQSNDESIHQHNAHAERVVEMATLREEIDGTHRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3N2</accession>
    <name>A0A3N6N3N2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92742">
        <property type="protein sequence ID" value="RQG92742"/>
        <property type="gene ID" value="EA462_00475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="167" mass="18680" checksum="08320A2F8159E129" modified="2019-02-13" version="1">MTRPARSRSAGDGLRRIADSLGFALLWCWILVSVLVVPTIVGFWWIGVLLFVLGLIVCWQAAEASRDPVYTIGTKRDVRTGQVDTAGVDCDECGRSAHGGEFRRYERRRVLFGTTIAVLESGENVYCEQCVVEPRERIEPTRDRSDPGADTSDERDGDFPELESERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4S2</accession>
    <name>A0A3N6N4S2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93192">
        <property type="protein sequence ID" value="RQG93192"/>
        <property type="gene ID" value="EA462_03050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="401" mass="43111" checksum="27C5C04F4D0E3A6A" modified="2019-02-13" version="1">MTLSLARRARRFPDRTAVVDVSEERLSAPAKTVHEDRVSYSELSDLATDAAKRLSALAVDAGDTVSLVTRNRVVSLALLFACRRLDATFAPISHRLTPETVERPFDAISPDIVVFEAAQRDLVRSIPHGRSITLEKLATVDPVGAARVDSGDTDRPLLVLHGDDGRPAVAFSERALEWNCISALVTWGLSADDVVPVVTPLSEPDGLVRVALSVVYAGGRLLLDRAFDPGDTITAIEAEDATFLSGRTVAFRDLAADPAFDAAADSLERAVADGSVPDALLAPYRERDVTVTRAYGRLECPTALCESAETVHPNRDDTVGVPIPDCRVRLIDDDGAVFEEAGTGRLLLSGPVVADGYVNAAASDDAAADDRFGGGRFLDGWFDTGERFRRDERGVYHIETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUS2</accession>
    <name>A0A3N6NUS2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_14935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86950">
        <property type="protein sequence ID" value="RQG86950"/>
        <property type="gene ID" value="EA462_14935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="14"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="273"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG86950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="335" mass="36838" checksum="7DC467C54A77796B" modified="2019-02-13" version="1">MSHDTPNPTTSNSITFDGVTKIYNDGTEAVSDVSFSVPNGETATLVGPSGCGKTTTMKMVNALVEPTSGEVSVAGTSLTEYDPIELRRKVGYVIQDIGLFKHMTIEENVGIVPDIIGWDDDRIETRVTELLELVRLGDEVRTKYPPELSGGQQQRVGVARALAAEPDVMLMDEPFGALDPITREQLQDEFRRIQEGLDVTIVFVTHDIDEALKMGDRVAVMRDGELIQYDPPAELLRNPNDAFVESFLGEDRQLAQLQTVFVRDVMGPADEAPTADHVPTLSPDDTLRLAVQAWLRSDTDAVPVVESDAVVGSITETHLRHVFEESSRPIEENHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUW6</accession>
    <name>A0A3N6NUW6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Twin-arginine translocation signal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87030">
        <property type="protein sequence ID" value="RQG87030"/>
        <property type="gene ID" value="EA462_15425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="468"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="538" mass="57929" checksum="C6FCAEE724734689" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWD5</accession>
    <name>A0A3N6NWD5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88839">
        <property type="protein sequence ID" value="RQG88839"/>
        <property type="gene ID" value="EA462_10585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="16025" checksum="A773B1C77B6FC7A7" modified="2019-02-13" version="1">MDIGLVSCTKSKREQAAKPADLYMPSTFFQKAREYVEANHDRWYVLSAKHHLLDPAGPPIEPYDDTLSGAPVARKREWAETVYGQLEDEGLLDEGNRLVFHAGRNYYSELIPLLDDTPVDIETPTDGLQFGESLAWYNEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWR0</accession>
    <name>A0A3N6NWR0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88999">
        <property type="protein sequence ID" value="RQG88999"/>
        <property type="gene ID" value="EA462_11475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="162" mass="18237" checksum="DAFADA6A3ACA88E0" modified="2019-02-13" version="1">MFRSGAFVADYISPTTDDQVQPNGVDLTLDVVFEQLEPGRIGRDGKQIGDRVARPLEELERKDPDTYYLPRGAYIARYGERIEIPDGHVGFVYPRSSLMRNSCMLNTAVWDAGYEGRGEGLLQVHHDIEIERGARIAQLVFAEASHEDVYDGSYQGENLEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX69</accession>
    <name>A0A3N6NX69_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4350 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89239">
        <property type="protein sequence ID" value="RQG89239"/>
        <property type="gene ID" value="EA462_12810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025646">
        <property type="entry name" value="DUF4350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14258">
        <property type="entry name" value="DUF4350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4350" evidence="2">
        <location>
            <begin position="160"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="494" mass="52986" checksum="17DE03614D345B53" modified="2019-02-13" version="1">MARADDPQPPGSVRSLATRLDARDGTRTLAFRREFSRVVLHLFADRAVGRHRTDRSVQRVAGLADAVAVAYSVRVRRLRGTRRQADTADRSSGGAAGVKSGPHGQSPGTDGDESDSWPAADLALEIDWSRVLVYALGAAVVATLAVGATASTTAFGPFNSEWDGGSEFRERVADDPETDGEILLKTTEYEALSDSETVAVVVAPEEAYADAEADRVRGFVERGGTLVVFDGVDHHGSDLLVNVGAHARFTGQHLRDEYRYDRGPMMPIATPATNHTLTDGVDRLTLNHATAVDPDPSSDSDRASRNVTVLFETSEFARLEESRMDRASETRAVAERNDESGPGPVSSVGSYPVATVEPVGDGRVVVVGDPSITINAMIDRPDNDDFLSNLHTGTDRVALDVSHGESLPPLSSALVTLRQSPSLQAFVGILAVVAVGLSSDRRVRLAFERLRLRLRGLIERIVWNGVSGSRGAHGQGVASNERTARDHQPSNTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYH1</accession>
    <name>A0A3N6NYH1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89879">
        <property type="protein sequence ID" value="RQG89879"/>
        <property type="gene ID" value="EA462_07645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="PTHR10293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="114" mass="12791" checksum="7434E0955A8233C1" modified="2019-02-13" version="1">MDFPPNQGLDQEEVDERVETAIEDNEVVLFMKGTALMPQCGYSKRALGLIDQYRDEYETVDALESLDEFRVALENQSGWETIPQTFVDGEFVGGSDILAELEERDELAATLGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYM6</accession>
    <name>A0A3N6NYM6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acylphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89949">
        <property type="protein sequence ID" value="RQG89949"/>
        <property type="gene ID" value="EA462_08035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="92" mass="10380" checksum="A121DC7E7B1FC065" modified="2019-02-13" version="1">MSERTRAHVFISGTVQGVFYRATTRDTARDHGIDGWVRNLDDGRVEAVFEGPGDAVESMVEWCHEGSQAAIVDDVDVEYEQPRSEDGFEVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYN6</accession>
    <name>A0A3N6NYN6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89969">
        <property type="protein sequence ID" value="RQG89969"/>
        <property type="gene ID" value="EA462_08150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="184" mass="21137" checksum="A45E4433C6604F7D" modified="2019-02-13" version="1">MKLTRSLVTAEARQYREQEPLFVVERENLKTLPGALESGEYGRRDAAWIVRWYYRRFLGEYPDEARRNAEERFWETDFDAVRTAISGAIDAPDAAVAVDRLTDLEAVDVPVASAFLMFIDPEAYVVVGPREWSVLSTTGELSEPYPDPPSVAQYQRYLEQCQSLADELDCDLETLYRALWRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYZ6</accession>
    <name>A0A3N6NYZ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alanine--glyoxylate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86706">
        <property type="protein sequence ID" value="RQG86706"/>
        <property type="gene ID" value="EA462_16340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="37"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="370" mass="41840" checksum="AC41C976F03F7521" modified="2019-02-13" version="1">MTKKSEYKFNYPNKKLYIPGPTEVRDDVIEAMCEPMFGHRMDQMTDLYTTIVEDTKEFLDTDNDIIILTGSGTEFMESSILNLVDEDVLVTTCGSFSERQTNVAERLGKTVDTLEYEWGQAVKPEDVREYLKKSDTDYDVVTCVKNESSTGVRNPVEEIGDVVAEYPDTSFVVDAVSSLGGDYVDIDEHNIDVIFTSVQKAFAMPPGLGVCVVSQDAYEAELEADSASWYGGFQRTLDYYDRKGQTHSTPAISIMLAYRKQMKHMLREGHDARDQRHREMAEYTREWAHEHFEMFPEEGYESQTVSCIENTRGIDVASTIDAVSEEYDMVFSNGYGSTLGEKTFRIGHMGEHDLESIKELTDAIEDVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZE8</accession>
    <name>A0A3N6NZE8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86916">
        <property type="protein sequence ID" value="RQG86916"/>
        <property type="gene ID" value="EA462_14750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="23"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="372" mass="40122" checksum="2851CC14ED51A21C" modified="2019-02-13" version="1">MKPIDLRETIPAIESGIYCNWGAGGPSPRRVVEAAESVLERHEYEAAFEGGQYRAAFDAYEESRAAIAGLLGASPDEIALTESTADGINRIASGLEWTADDVVVRTDLEHSAGILPWKRLERERGIDVRVLETDGGRVDLEAVADAAADATLFCVSSVTWTHGTRLPVAEIVEIAHEAGALVLVDAVQSPGQTPVDVREWGADFVVGAGHKWLVGPFGSGFCYVREGRERTLTPAAIGYRSVAEPNADDYRYEAGARRLEVGSATPAAHAGLVDAIDCFGEMGLETVERRIERLTDRLKAGVDEDRLISPDRFESGLVTIATDDPEATVQRLAEEDIVVRSLPSSAAYPRAVRVSVHAFNAREEVDAVLEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZH5</accession>
    <name>A0A3N6NZH5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH bat-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86946">
        <property type="protein sequence ID" value="RQG86946"/>
        <property type="gene ID" value="EA462_14915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="175"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="242" mass="28090" checksum="1F37B756ED716423" modified="2019-02-13" version="1">MDSSELNEDRIASVRLRIRMTDDWTERIGQYDIQGDIFTASLLDTHYKALVRLYGEDVSRGIEIIEKAPYHTRVDVIEQSLDTTHEYAVLFVTAVFDRMTPFRILTENEYLLFEPSFFRNGWFYIDTLIWNRDQLSFLIDRLDEICTVSIEQLISGAEFSTLPNPLTWSTLLSELTDRQMEVLSLALERGYYDQPSRVSLEELGTELDLHKSTVGEHLNRATQTLATFITENYYPATYGKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZH7</accession>
    <name>A0A3N6NZH7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LysE family translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_08850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90369">
        <property type="protein sequence ID" value="RQG90369"/>
        <property type="gene ID" value="EA462_08850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="221" mass="22663" checksum="AA3B2630AAF6915E" modified="2019-02-13" version="1">MTALAGVVFGLALAAPPGPMNAIIAEESVVSGWRAGFRAGLGAMVADVLFFVLTLAGVVTVIDRYQVVRPALYLAGGLLMLYFAVGAIRAARSAASFTGDGQRASKGFRKTFALSLTNPYQIGFWLTVGVGLLESGSLDVLSYVPAAGDGLAGLLVVQTGSPALLFGFFAGIGLWIVTYPATLVSIGRRVDRFAPAVSALSAVVLAGFGLVFFVVGVGQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0I9</accession>
    <name>A0A3N6P0I9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_14165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87998">
        <property type="protein sequence ID" value="RQG87998"/>
        <property type="gene ID" value="EA462_14165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="100"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="742" mass="83065" checksum="AE3BCD6CD2A780C4" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1A2</accession>
    <name>A0A3N6P1A2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="5">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">glmS</name>
        <name evidence="8" type="ORF">EA462_04575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91269">
        <property type="protein sequence ID" value="RQG91269"/>
        <property type="gene ID" value="EA462_04575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="280"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="455"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="5">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="604" mass="64750" checksum="F1D4AA30D15497F4" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1D6</accession>
    <name>A0A3N6P1D6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88875">
        <property type="protein sequence ID" value="RQG88875"/>
        <property type="gene ID" value="EA462_10785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="72" mass="7646" checksum="AA8D0497A63ACD5B" modified="2019-02-13" version="1">MGSSRSPAPWKSRDWIGRILESPVCRRLESAVRPKGPDGLEAAMGCGTAAGLEVDARFEIAVNVGFIGRSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1E4</accession>
    <name>A0A3N6P1E4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LLM class flavin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88885">
        <property type="protein sequence ID" value="RQG88885"/>
        <property type="gene ID" value="EA462_10840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="342" mass="36481" checksum="88E5A6AC5F0B6686" modified="2019-02-13" version="1">MELSAVDLSPVPDDGTAADAYANTVESAQQAERLGYSRFWVAEHHGTADINAGTTPEVLLGHLAAETDSIRIGSGAVLLNHYSPFKVAEVFGALDALAPGRIDAGLGRANGSPAADRALETERHVQNPDEDHAEKITAVVNHLFDDYPDGHDYGDLEIPRSSESAPVPWVLGSGPSSAAIAGKLGLRYCFAAFIRPQFAANAFEEYRDQFRSTELAGSVDEPHGMIAVDAICAETDEEAARRRAVSEAFYRRLQRGALEGIPSVEEAVDELGGVPEPTPATLGPDEWPQTISGDPDTLAGLLEQLAGRVGVDEVMIKHVVADHDHALRSHELLAEGVGLEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P239</accession>
    <name>A0A3N6P239_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89195">
        <property type="protein sequence ID" value="RQG89195"/>
        <property type="gene ID" value="EA462_12580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="129" mass="13782" checksum="3861583D6857BF41" modified="2019-02-13" version="1">MSDTHPIETDDAPSGDNPYSQGVRTDGTLYVSGYGPVDPKTDEPVDGDIRSQTEQVLENVAAVVAAAGGDGLTDVVKVTVYLTDLETYDRVNEAYGECFEDDPPARVCVEVSRLPGDVRVEMDAIASLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P469</accession>
    <name>A0A3N6P469_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="4">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">ftsY</name>
        <name evidence="7" type="ORF">EA462_09200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90155">
        <property type="protein sequence ID" value="RQG90155"/>
        <property type="gene ID" value="EA462_09200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="231"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="313"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="421" mass="45010" checksum="4D92971B76222737" modified="2019-02-13" version="1">MFDNLKKKLGSFREDAEEAAEENVEDVEEGDLEEDDLETGDEDPSTNETTTSVDAAADPPSSRNEGAEGAPKTAVSSDRQDGSSDGDLETDRDERTDPGAGRAGVVSDDGPADDATGDEPDEDSGSTGFGRKAKSLVKGKFVIEAEDLEGPLHELEMALLSSDVEMGVAEEILDNIRDELIGETRTFTTSTGDVVENALRDAIYDVISVGQFDFDERIALEDKPVTIVFTGVNGVGKTTSIAKLSRYFEDRGYSTVVANGDTYRAGANEQIQEHADRLETKLIAHEQGGDPAAVLYDAVEYADANDVDIVLGDTAGRLHTDEGLMDQLEKIDRVVGPDMTLFVDEAVAGQDAVNRAREFDAAAEIDGTILTKADADSNGGAAISVAHVSGKPILFLGVGQGYDDLERFDPDEMVDRLLAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P662</accession>
    <name>A0A3N6P662_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl24e</name>
        <name evidence="7" type="ORF">EA462_04285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91215">
        <property type="protein sequence ID" value="RQG91215"/>
        <property type="gene ID" value="EA462_04285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00773">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023438">
        <property type="entry name" value="Ribosomal_L24e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_L24e-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="138" mass="15225" checksum="EC53292F8FF6A5DA" modified="2019-02-13" version="1">MVEKRTCDYTGEDIEPGTGIMYVRNNGTVLHFVDSKAEKNYKLGREPRDLEWTAQGRASKGPTEVETEPDADEKEEDADEDEDLEADDEPAESETADDEDEAVDSDVDADDSDADADADTESDEAVEPDAEDEAEDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6D2</accession>
    <name>A0A3N6P6D2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase beta</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">polX</name>
        <name evidence="21" type="ORF">EA462_04855</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91315">
        <property type="protein sequence ID" value="RQG91315"/>
        <property type="gene ID" value="EA462_04855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022311">
        <property type="entry name" value="UCP005047_YshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005047">
        <property type="entry name" value="UCP005047_YshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="21" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="21" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="POLXc" evidence="20">
        <location>
            <begin position="2"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="19">
        <location>
            <begin position="351"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RQG91315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="583" mass="63541" checksum="35618A3744FA3CC6" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6R7</accession>
    <name>A0A3N6P6R7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91555">
        <property type="protein sequence ID" value="RQG91555"/>
        <property type="gene ID" value="EA462_06240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="63" mass="6768" checksum="D0F26907A7BFAC78" modified="2019-02-13" version="1">MLLLAIHGRTLVDDPVVLDESAESVSITMTATAADDPLEARRVRQSSNIRTTIPYGSANSIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9C6</accession>
    <name>A0A3N6P9C6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92825">
        <property type="protein sequence ID" value="RQG92825"/>
        <property type="gene ID" value="EA462_00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="143" mass="17175" checksum="3E3BDA7F35C1D5C7" modified="2019-02-13" version="1">MVPVNDGRSPAPIDRSVLERLRSQFLGSRMFQSAEIVTAGKLHLRVDLSDEYYPNEVSARLEIRWYRNDEFNVHYQEERQDSAWKCRWDRHPNVHNSRDHFHLPPTSSRSDAQNEQWPVDHRDVSRLVLNRIEERIEVLWEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA72</accession>
    <name>A0A3N6PA72_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="2">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Phosphoriboisomerase A</fullName>
            <shortName evidence="2">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rpiA</name>
        <name evidence="3" type="ORF">EA462_03365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93245">
        <property type="protein sequence ID" value="RQG93245"/>
        <property type="gene ID" value="EA462_03365"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="235" mass="24403" checksum="BC6D0BDCB1C90B73" modified="2019-02-13" version="1">MKTEGGTDEAKRRAGERAARAVEDGTVVGLGTGSTTACAIDALGRAVADGLEIRAVPTSFQSRRLALEADIPVTELDAVDRIDLAIDGADQVVDQPAASAHGALIKGGGAAHTREKLIDATAERFVVVVDPSKLTDELDRSVPLEVLPDAHSVVGDRVRELSGEPTLRDATGKDGPVVTDNGNLVLDCAFGAISEPGDLASRLSRIPGVVEHGLFVGLADATYVGTDDGLEVREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI09</accession>
    <name>A0A3N6LI09_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="7">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_14690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86904">
        <property type="protein sequence ID" value="RQG86904"/>
        <property type="gene ID" value="EA462_14690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="5">
        <location>
            <begin position="42"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="6">
        <location>
            <begin position="306"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="555" mass="62416" checksum="BE144B992504E739" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI30</accession>
    <name>A0A3N6LI30_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86739">
        <property type="protein sequence ID" value="RQG86739"/>
        <property type="gene ID" value="EA462_16525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="111"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="486" mass="54245" checksum="342544F7E5493A92" modified="2019-02-13" version="1">MDESRLVGVHLGTSSVRVATYDPDGTLIADGEAPIEEQTTIAWERALRSAAPALPSSGTCSVASTSGTVLLVDEYGEPVFPPQMYYESAPEQAKRLRQLDVGNDLTNWDVVSSSAGPLAKVLQLREDHPDRFEDVEWVLSPTTWLLYRLRYGRSSVWKTVETDWTNAMKFGADITVSMPEWNSSLFEACDLSSTLFPAIRPPGSYIGSAESEVAERTGFGGCKLYQGMTDGSASVLANGCLEPGDFSVTFGATSVIKYVLDEITPHEALYYHRHPLDGYILGASFDSGSVLRWYFNHVLDVAPEHGFELAKSIAPGQEYEVFLQGHRSPLYDPSVGTSLLGVECDTSLSTEAVRGRIARGLMTGIVLAEWTYIYRIQEHFDTTIDRIQLMNDGAPSLHDDYNWWNELRGQIWNRSITEMEPRMTAGLLIPAALITSEYADSNEAVNCLLRQRSEIEPASDQIGDYDDRRDRYLDRWYQVADLYDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIT7</accession>
    <name>A0A3N6LIT7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_13565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87886">
        <property type="protein sequence ID" value="RQG87886"/>
        <property type="gene ID" value="EA462_13565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="20"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="485" mass="51556" checksum="DC271D5204818F99" modified="2019-02-13" version="1">MASPAADDTGPFINGEYRSAAETFDIENPSTGETIATVGIADEETVDDAIETAREAQREWAALDASERGRVLRRVGERLTDSVDELAELESLEMGRPIGQSNGIITDGLGYFEYYGGLCDKIQGETIPVDGNRLDYTQKEPLGVSAQIIPWNAAVMLGIRGIVPALAAGNAVVAKPSSEAPLSVLKFAELATEAGIPEGLFNVVPGPGSRTGATLTEDPRIDEITFTGSVTGGTMVGKAAMENVIPVSLELGGKSPSIVFEDADLDAAIEDTLKVFFNSGQVCFATTRVFVHEEIYDEFTSRLAAATESMSIGPGIDGHDIGPVISADALDDIEEYVSTAKADGARVLTGGSVVERNGNYFEPTLIDSVDDDAPISCEEVFGPVITLYEFSDETEVIRRANDTEYGLYAAVWTDTLDRGHRVANGLEAGTVAINEFPATFPQAPFGGYKKSGLGREKGIQAIDHYTQLKNVVVSLGESDGTVFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ26</accession>
    <name>A0A3N6LJ26_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XdhC/CoxI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87841">
        <property type="protein sequence ID" value="RQG87841"/>
        <property type="gene ID" value="EA462_13315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="213"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="384" mass="41317" checksum="33E81C190E80EDC7" modified="2019-02-13" version="1">MDTDELDPWSATTAELYRTLRARLDGDDPAVLATIVDVDGSAYRRQGAKMIVVPGDDSYGSITAGCLEGPVVDLANAVLDEGRARVETFDLMNGDEWGLGLGCNGVIDILLEPLDNNFGVALDALANDQPVTVLTAVESSDGNVTVGDRTVLDSDLSSLGDADRNRLPSELVSNESDVVESLRESASSKAVQLETSAGTVSVFVDHLEPVPELLLFGNQNDVHPVARIGREAGFRVVVASSRGSRSDGSDFPYATRVVSTHPTEIDEAVRAPENTYAVLMSHNFLDDRLALETLLEGTSVPYVGLMGPRKRFEEMQTEFEQEGVQLSQSQLERVSTPVGLDLGSDEPIQIALSIVSETLAVHNDRNGGRLKCREGPIHERVTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJC9</accession>
    <name>A0A3N6LJC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88011">
        <property type="protein sequence ID" value="RQG88011"/>
        <property type="gene ID" value="EA462_14230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="147" mass="16665" checksum="33BA7341E0E0F543" modified="2019-02-13" version="1">MPVTSTPIESDDFDVDFGGREVPQFFRVNLPKRNIPVIEHQVGSGPRHPIKHADQPDFGGTFTAELYAQSGKSAIDKWWEAMRDFSDDEHEQVISVTAKDPSDNPVVRWKFTNARMVKYEYGDTLSGGEAIKIIITISYDKMDREMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJD7</accession>
    <name>A0A3N6LJD7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-formyltetrahydrofolate cyclo-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88783">
        <property type="protein sequence ID" value="RQG88783"/>
        <property type="gene ID" value="EA462_10270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="PTHR13017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="249" mass="28193" checksum="7841079CCDB099AC" modified="2019-02-13" version="1">MTDEGVLDPDDADKPAIRERVWDDLEESGTARFPFPPHGRIPNYENAMTAAERLAEQPEWTEASTIKANPDAPQLPVRRRALRDGKTVYMAVPRLREERCFLKLDPDELEDFDAATTVSGSSEHGRPVHPDEMDRIDLIVSGSVAVTDDGNRVGKGEGYSDLEYAILRELDLVDDETPVATTVHERQVLDDAIEADDHDVPMDLIVTPERVRRPDERDSPTGIDWDRLDPDRLEEIPVLERLREKHGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJK3</accession>
    <name>A0A3N6LJK3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88893">
        <property type="protein sequence ID" value="RQG88893"/>
        <property type="gene ID" value="EA462_10880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="49" mass="5237" checksum="D7F1338B262C25CD" modified="2019-02-13" version="1">MSRHQFTCPECGQEIEVNESMREATLTHGCPVCGASVTSSAFAETQSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJN2</accession>
    <name>A0A3N6LJN2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86144">
        <property type="protein sequence ID" value="RQG86144"/>
        <property type="gene ID" value="EA462_16870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="15185" checksum="17FF5C0E4071A4B3" modified="2019-02-13" version="1">MTLTFDGTVVVPVADPDDGERTTAALEPYLTSTSTVVVVNVIEKAGGGIDKAPMAQREEYAEKIYERARRALEDSPASVEFDTLYGTDVVETIFAAAEDRSADAVAFTPRKGNRLAELLTGDVARRIVREATIPVVGLPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJU9</accession>
    <name>A0A3N6LJU9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_17195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86204">
        <property type="protein sequence ID" value="RQG86204"/>
        <property type="gene ID" value="EA462_17195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="262"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="372" mass="38112" checksum="6ADB245E0D84B062" modified="2019-02-13" version="1">MPSRQRPCSRRRMLALALGTSGLIGGTTVTGATRSVSSSEIGGGETNGSIQNDDVDSDGYAAVYEETIDDVVLVAIRGSNDDPGGLGSGFVLENGFVVTNHHVAGDADGVEVQFRDEQWRTGTVVGSDRHSDLAVVEIDDLPEIVSGLSLWEAEPVIGSEVLALGNPLGLDASISQGIVSGIDRSLPSPTGFSIPAAIQTDAPVNPGNSGGPLVTLEGEVLGVVFAGLGQTIGFAISALLADRVVPALIGDGAYDHPYLGVGVLPVGPQVATANDLEEPRGVLITDVEPGGPADGVLESATERETIDGDSVRAGGDVIVAIDGHDIPNEEILSSTLALETSPGETIEIDVVRDGERGTLEVTLSSRPDVDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJW3</accession>
    <name>A0A3N6LJW3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89063">
        <property type="protein sequence ID" value="RQG89063"/>
        <property type="gene ID" value="EA462_11840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="126" mass="14180" checksum="5C6922E32B851955" modified="2019-02-13" version="1">MDVDTLYTEGNVFGLPVLGYREQSYTIIADGETADTEFRDDHPDGSDFAEETNFEESYILVAQYGTRSEEDLVLDSIERIESGLRVAISVDKPFLIDHDDLKTHSYLIRITDKEGVPDSVDLTIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJY5</accession>
    <name>A0A3N6LJY5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PIG-L family deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86668">
        <property type="protein sequence ID" value="RQG86668"/>
        <property type="gene ID" value="EA462_16120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="233" mass="25755" checksum="D2066B91924C98F6" modified="2019-02-13" version="1">MKLLAIVAHPDDADIFCGGTIAKHADRGDTVTIAHMTKGEYGGFDTDRETVAETRAEEARRSGDELGAADVTFLGFPDGRIEYSLENRLEIVETIREHDPDLILTHYREDMHPDHRVTSRLVTDAYYMASLPLVETEYEPCDPDNVYCFGKPTSTFEPTTYVDISGYENRKAAAIDHHESQVAFLEEHGGIDAEFDNLIEGVAAENATLGKKTGVNSAEGFLALHEQANDYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK80</accession>
    <name>A0A3N6LK80_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88988">
        <property type="protein sequence ID" value="RQG88988"/>
        <property type="gene ID" value="EA462_11410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="22"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="401" mass="42198" checksum="639E2627834B4076" modified="2019-02-13" version="1">MKVRTVVGRELKAVWGDGRGVSLAVIAIGWGLLMGSRMILPVIIPYLQTVHGLSLTVAGLLVSVLWLFASVGQLPGGVLADKYDERTIMAGSVIVVAVALALVITAPTPLVLFLATALWGLGSSLYPIARITFLSNLYTERLGSALGLTMATADVGQTVFPPIATVLAVTVAWQAGLGFMIPLFVLAGIGLFVILSDRDGSDHPTGSGSLRDALDVLPEFRTPAMAYMTGILFLYFFIWQSFTAFYPTYLTTVKGLSPSVSSLLFGSFFAAGVLIKPLAGAAYDRIGARISLIAILVPPVAGFALLPFVDNVWLLVGITALVSTMLGSGAVTQPYLADSFSNEVKGTGLGTVKTITLTLASGGPVLFGVIADYGYFNEGYLVLAAVTAIVVVFTFWMPDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKS4</accession>
    <name>A0A3N6LKS4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Na(+)/H(+) antiporter subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87088">
        <property type="protein sequence ID" value="RQG87088"/>
        <property type="gene ID" value="EA462_15765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="118"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="610" mass="64655" checksum="65B3C14BCEC8CCDA" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLD6</accession>
    <name>A0A3N6LLD6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89773">
        <property type="protein sequence ID" value="RQG89773"/>
        <property type="gene ID" value="EA462_07070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="103" mass="11233" checksum="C58501E3B10CA26C" modified="2019-02-13" version="1">MSSPDKTSPPRDAVPPSQAIIEAIAAHEGVDVTEIEPPEYEPLYEVVNPEALDSLFRTPARTSETTRLLLEYEGYDVTVYGDGRVEVTDSSHSNNSVGTPIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLS5</accession>
    <name>A0A3N6LLS5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89848">
        <property type="protein sequence ID" value="RQG89848"/>
        <property type="gene ID" value="EA462_07475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="123" mass="14145" checksum="C399005781286751" modified="2019-02-13" version="1">MNDRSVSVSELREADLDHSVEELLRLFSDPSVRATIRWLYERPDTTIDELASVIVAEQAADEATIATESEYERERIRLHHVVLPRLDDHDMITYEYDSGTVTETDIHEAIRSFLGVDTDERPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LME7</accession>
    <name>A0A3N6LME7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90188">
        <property type="protein sequence ID" value="RQG90188"/>
        <property type="gene ID" value="EA462_09375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="14779" checksum="7ACF6AE0B04E0F10" modified="2019-02-13" version="1">MFETILVPTDGSEYAESAAEMALELAKTHDAAVHVLSVADTGPLESIRLPGDAASPEGAFRARAERAVETIVSRGEETGLEMTGTVRTGPAESEILEYATEVDADLIVMGTRGRGGVTRAALGSVTDHVVRLGDVPVFIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LN58</accession>
    <name>A0A3N6LN58_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metal-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_15330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87015">
        <property type="protein sequence ID" value="RQG87015"/>
        <property type="gene ID" value="EA462_15330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="142" mass="15815" checksum="A371B1DFA7DE80C1" modified="2019-02-13" version="1">MNTADQYLKAIYLAQRMDEGPASTGTLADILGVSPASVNEMIGKLENRGFVEHEKYKGASLTDEGLERAHNALQTYCIIERFLTNVLEVAEFRDEARTLESVIDDTVAERLDTIIDRPAECPDCFDPERDCCERLEVCGPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNF3</accession>
    <name>A0A3N6LNF3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87135">
        <property type="protein sequence ID" value="RQG87135"/>
        <property type="gene ID" value="EA462_15510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="73" mass="8201" checksum="ECBBEBB25F4330A0" modified="2019-02-13" version="1">MRPTFERSPTRKATLYCFNCGHKSILSGDWIVRTHGECIDYECPECRTRIATRPTRTDSVADSNGGLCYSPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNQ2</accession>
    <name>A0A3N6LNQ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87807">
        <property type="protein sequence ID" value="RQG87807"/>
        <property type="gene ID" value="EA462_13115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="305" mass="33636" checksum="2562D57076235C65" modified="2019-02-13" version="1">MTLLGDALTKNQRIVLETYKERTQWAVQRFLSNRMAAIALLIVLGTLFMAIFAPFLAPYEPQANIADAQGEYSMLEPPSSEHIMGTNHHSQDILSQWIYGSRVSLLVAFLSGIAVMLIGTTVGLVSGYYKGTVDLVLMRVVDILYAIPAIPLLLVVSLLFGSSVWNVIIAMILILWRTMARVVRSQTLSLSERPFVKAAKASGASDLRIMYVHIAPNLLPIILIEGVFVMGAAILLEAGISFLGLGTTEMISWGVMLQLTYTSGAITHAWWWVLPPGISITVLVVAFFYMSRGIEEITNPELQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP05</accession>
    <name>A0A3N6LP05_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87957">
        <property type="protein sequence ID" value="RQG87957"/>
        <property type="gene ID" value="EA462_13930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="137" mass="15644" checksum="3C45798FBDEF9848" modified="2019-02-13" version="1">MFTHTITARFEDIDYAGRVFYGRLFNYVHVTEEEWFAEMGYTIPRLDEELGVLFPIAHAEGDFRGPIELGDEVAVRVGVDSIGTKSFDVRAVARNTTHDYEAFEIELTRVCLSTREPGTTVEIPATFRDALEAYVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP91</accession>
    <name>A0A3N6LP91_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_07920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89927">
        <property type="protein sequence ID" value="RQG89927"/>
        <property type="gene ID" value="EA462_07920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="381" mass="41489" checksum="5A9FCA5FE9127377" modified="2019-02-13" version="1">MDFALSAEQTQIRQMVSEFVDEEIVPVAAEIDHEDEFPRDLIDEMADLGLLGMPFPEKYGGAGLDYHSYVIGLEEISRGSGGLGTVVAAHTSLAGNMLYEFGDERQKDEYLTPLAGGDDVGAFALSEAGAGSDVPAMETTAERDGDEYVLTGGKLWISNGSVADTVTVFAKTDPDAGNNGISSFIVRPEEDDGFVVEGTEEKLGDKGCPTAELRFDDLRLPEDRLLGEEGEGFVQALKTLNAGRITIAARGVGIARAAFDEAVSYANEREQFGRPIGEFQAIKHKLADMDTKIQAARMLMHRAADRKIRGEDYITEAAQAKLYASEVSREVANEGIQIHGGYGYTTDFPAERFYRDAKLNEIYEGTSEVLRNTIGDRLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPL9</accession>
    <name>A0A3N6LPL9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91423">
        <property type="protein sequence ID" value="RQG91423"/>
        <property type="gene ID" value="EA462_05480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005104">
        <property type="entry name" value="WHTH_HrcA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03444">
        <property type="entry name" value="HrcA_DNA-bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HrcA_DNA-bdg" evidence="1">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="177" mass="19279" checksum="AFBC0325EC3A8903" modified="2019-02-13" version="1">MSSIELTPSQKKILRALTNLHKESEDAIKGEDIAEQVDRNPGTIRNQMQSLKALQLVEGVPGPKGGYKPTAAAYEALEIQQMDDPASVPLEHEGESVEDIIVEEIDLSSVHHPELCRAEIHMQGSIDDFSEDDAVTVGPTPLSKLVVEGRVDGKDDTNNILILRIVDMIAPADEPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPS5</accession>
    <name>A0A3N6LPS5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetyl-D-mannosamine dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.336</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-ManNAc 6-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_06030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate</text>
            <dbReference type="Rhea" id="RHEA:25780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:68623"/>
            <dbReference type="ChEBI" id="CHEBI:70731"/>
            <dbReference type="EC" id="1.1.1.336"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91518">
        <property type="protein sequence ID" value="RQG91518"/>
        <property type="gene ID" value="EA462_06030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="8">
        <location>
            <begin position="310"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="420" mass="45736" checksum="E757B0CD94917FA0" modified="2019-02-13" version="1">MMDDNPRICVHGLGYVGLPTAAILANSGFDVYGFDVDPQHRRDLKNQDFTFEEPDLERFVSGALEDGLTIVGDPRPAEFHVICVPTPYDENLDRTDLTYVEAAGETVASLLRPDDTVILSSTVPPGTSAEKLREIVEREGFSASEDVVLGYSPETVLPGNTLRELRENDRLVGTVGGRQPDRIVALYDSFVSGDIRTTDATTAEFVKLVQNAYRDVNIAFANEVAKLADEFEIDSRGSIALANNHPRVDILRPGPGVGGHCIPIDPLFLNHGNDIPMLIETARRVNDGMVGFVEQLLEAALGELAGSTVTILGVAYKGGVADTRKSPCFALIDRLARTEVDEIRLTDPYVNGEVRGRELVALEESLEASDASVILTDHPEYGALDPEVFADRMAGRTVVDTRAMVDEDRWAAAGFDVHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPW2</accession>
    <name>A0A3N6LPW2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TrkA family potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_06385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a potassium transport system.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91578">
        <property type="protein sequence ID" value="RQG91578"/>
        <property type="gene ID" value="EA462_06385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="237" mass="25346" checksum="48AE50AFF3FE7EEF" modified="2019-02-13" version="1">MRFVIIGAGRVGLRTARVLRDEGHEVTLIERDDGMIRRARNEAFSVVEGDGSQETVIEEAGIANADVLGALTGDLNVNFTACMIAKHHGCRTVMRIDEAYREGIYRKYADEVDEVIYPERLGALGAKNALLGGTIRAIADVAPHLQVLELTITDQAPVNGYAMGELQLPADATVLAFGKQDRTLGIPSEDESLEVGDRLVVLADFDVLSEVRQLLVGETASRALVGADASGDSGGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPX0</accession>
    <name>A0A3N6LPX0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF4010 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_11280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88964">
        <property type="protein sequence ID" value="RQG88964"/>
        <property type="gene ID" value="EA462_11280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025105">
        <property type="entry name" value="DUF4010"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13194">
        <property type="entry name" value="DUF4010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4010" evidence="7">
        <location>
            <begin position="194"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG88964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="430" mass="43890" checksum="0A7877528658BEDD" modified="2019-02-13" version="1">MNEAALQIADAPLDESVVRIALAGALGLFLGLEREWSQKSAGIRTFSLISLLAAVFTLLALETALGNGLLILGGALVIVQGVLLAIRGLAGEGDAGLSLTTSVSMLVAYGIGALVAAGFIIEGVTVAVLSSLLLVLKRELHEFAWGLSREEMRSTIEFAILAFVIYPLLPAETELHLGVLTIPLEPQIIWLMVVAVAGIGIVNYAIVSTYGGRGIAITGFFGGLASSTAVVGTMLDHVRQRPEAATYAVAAILLANAAMAARNLAIAVGFTVGTGTDILLEAVVPLGAVIVIAFAIAGAIADWAESGPMELRSPFSMKNALAFGAVFLVVLVFGSLAETWFGTLGFYATAVASGFVSSAGATTSAVVLYRGGQLGAAEATIAILLATVSSIVVKAMLAATSTNDAFRNQVAAYSAVLLLGGGAASVLIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ19</accession>
    <name>A0A3N6LQ19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytoene/squalene synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91658">
        <property type="protein sequence ID" value="RQG91658"/>
        <property type="gene ID" value="EA462_06845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="316" mass="35872" checksum="E08928AF44E0A9B1" modified="2019-02-13" version="1">MQQEHIDAGKAIQKRTGKTFYLATRFLPERVRHATHVLYAFFRIADEVVDDAGGVPPEDQRAELETLRAQALGETEPENPVLKAFQNLRGRYDIADEEITEFIDAMATDITTSRYETYADLESYMRGSAAAVGVMMTAIMEPETEETALPHAIKLGEAFQLTNFLRDVREDVLERDRIYIPQETLRKHGISSEEIEALECSDGFKAAMSEELKRTEKLYREGVAGIRYLPTDCQLPVLLAAVLYAEHHALIRSQGYDVLASEPSLSTWRKLLCLAKTRWHWHWNRDPEAVFQRVSAVPVSDAEALDSRFGGRIPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQK0</accession>
    <name>A0A3N6LQK0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalt-precorrin-7 (C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.289</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_12890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.289" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89254">
        <property type="protein sequence ID" value="RQG89254"/>
        <property type="gene ID" value="EA462_12890"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="266" mass="28378" checksum="6B38A0A7A43746B1" modified="2019-02-13" version="1">MTDDYDLDSGPDPATFAAAAPEPTVDETAADPVYVVGVGPGHPAYRTPRGERAISEADVVVGFETVVELVEDVTDADLLTCGYRDEAEALAAFGERVAAGERGTAVAMGDPNHSGYQFVGKIQAAVEREADRRGTDPKPIRVIPGISSLQVAASRARTPMEETEFVTLHKSGDLDADMDRLVAAVDDRNLLVLPRPYDRMPGDIAAFLLDRGADPTLEALVLEKLTHADEAIHRYSLAELSEHAGGDGSEDTPFSDLVVLAVRQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS65</accession>
    <name>A0A3N6LS65_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl19e</name>
        <name evidence="9" type="ORF">EA462_05115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91357">
        <property type="protein sequence ID" value="RQG91357"/>
        <property type="gene ID" value="EA462_05115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01418">
        <property type="entry name" value="Ribosomal_L19e_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_L19/L19e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_L19/L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_L19/L19e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_L19/L19e_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033936">
        <property type="entry name" value="Ribosomal_L19e_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015973">
        <property type="entry name" value="Ribosomal_L19e_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015974">
        <property type="entry name" value="Ribosomal_L19e_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="RPL19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="PTHR10722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="SSF48140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L19e" evidence="8">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="149" mass="17153" checksum="45BE85815B72B95B" modified="2019-02-13" version="1">MTDLSAQKRLAADVLDVGQNRIWFDPTAQGDIAEAITRDEIRELVDDGLIQADDARGNSRGRARKRNEKRSYGHQKGAGKRKGKKGARQNEKEQWQNKIRAQRRTLRELRDKGELTPTQYRELYKKAGGGEFRSVQYLLNYIDDNYGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS91</accession>
    <name>A0A3N6LS91_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="3">DHBP synthase</shortName>
            <ecNumber evidence="3">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ribB</name>
        <name evidence="5" type="ORF">EA462_00560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92758">
        <property type="protein sequence ID" value="RQG92758"/>
        <property type="gene ID" value="EA462_00560"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG92758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="27168" checksum="80BF0593B3DAF36A" modified="2019-02-13" version="1">MTSRRGETRTAADGGTDTTASTDADGRAEPTETNARASTAAQRSVEDAIEALRAGEPVLVHDAADREGETDIIYHADAVTPEAVARMRNDAGGLICAALGYEVAEAFDLPFYTEEIDHAATRDHDLGYDERSSFSLTVNHRDTYTGITDNDRSKTIQALGEAASTPSAVDFADEFRTPGHVHVLKAAPDLLAQREGHTELGVALAEAADLSPAVVVCEMLDDDTGNARTPADARSYADRHDVTYLEGGHVLEQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSG4</accession>
    <name>A0A3N6LSG4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="5">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">glmS</name>
        <name evidence="8" type="ORF">EA462_09515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90214">
        <property type="protein sequence ID" value="RQG90214"/>
        <property type="gene ID" value="EA462_09515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="285"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="449"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="5">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="600" mass="64401" checksum="363BE7B5BD67B55E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSJ5</accession>
    <name>A0A3N6LSJ5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribulose bisphosphate carboxylase</fullName>
            <shortName evidence="1">RuBisCO</shortName>
            <ecNumber evidence="1">4.1.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">rbcL</name>
        <name evidence="4" type="ORF">EA462_05810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:23124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="4.1.1.39"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36631"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuBisCO large chain family. Type III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.39" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91477">
        <property type="protein sequence ID" value="RQG91477"/>
        <property type="gene ID" value="EA462_05810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01133">
        <property type="entry name" value="RuBisCO_L_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033966">
        <property type="entry name" value="RuBisCO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017712">
        <property type="entry name" value="RuBisCO_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000685">
        <property type="entry name" value="RuBisCO_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036376">
        <property type="entry name" value="RuBisCO_lsu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017443">
        <property type="entry name" value="RuBisCO_lsu_fd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036422">
        <property type="entry name" value="RuBisCO_lsu_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704">
        <property type="entry name" value="PTHR42704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00016">
        <property type="entry name" value="RuBisCO_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02788">
        <property type="entry name" value="RuBisCO_large_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00014">
        <property type="entry name" value="RuBisCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51649">
        <property type="entry name" value="SSF51649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54966">
        <property type="entry name" value="SSF54966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03326">
        <property type="entry name" value="rubisco_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="1 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_large_N" evidence="3">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="RuBisCO_large" evidence="2">
        <location>
            <begin position="134"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="339"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="361"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="416" mass="44107" checksum="8865340FAB15CDD3" modified="2019-02-13" version="1">MTGIEYDDFLDLEYEPASTDLVCTFTIDPATDMSMEAAASRVASESSNGTWAALHVDEAELTDLGAVACGIDGSRVTVAYPADLFETGSMPQILSCIAGNIMGMKAVDSIRLEDCTWPASIVDGFPGPQFGTSVANELLDAGERPVLATVPKPKVGLSTSAHVDVGEAAWRGGIDLLKDDENLTDQAFNPFEDRLAESLAARDRVQEDVGERKDYLVNVTAETNKMLERVDLVAEHGGGFVMIDVITCGWSAVQTVRERCADHGLAIHAHRAMHAAFDRTDHHGVSMRVIAQIARLCGVDHIHTGTAGLGKLENEDTPGINAWLHGECHGLQPVLPVASGGLHPGVVDQLIDALGTDICIQAGGGIHGHPDGTHAGAKALRQATEASLEGVSLEADAEEHEELATALEKWGAETPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LST0</accession>
    <name>A0A3N6LST0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_02130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93033">
        <property type="protein sequence ID" value="RQG93033"/>
        <property type="gene ID" value="EA462_02130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="386" mass="41651" checksum="AE6ED4EA9706EA13" modified="2019-02-13" version="1">MNEKRTAVTFFGFAVAAVTTYIAYRFIAALTVAVFLYYSTRRFYTSLERLHLPDKVRAVLVISFLAVPFLALVSYTVALLVIEVRNFVAEYPVAEMLPDDVGWVQGLENPPELTIQGLAEAYRAGTFDPFLDFTIDNAGLLTDLVTGFLLNLLIVVVVTYYLLIDGSKAHEWLLRFDDDAIVREYLEAVDEELEAVLFGNLLNVILISLIAVITFMGYNALVPAAVEIPYPALAGALTGVASLIPVVGMKIVYVPVAIAAAVPLVLDGQTALLVYLLGFLALAVVVVDTIPDLVLRPYLSGKRTHVGLLMLAYIFGPIVFGFYGLFLAPIILVLGLTFADTALPRLLGAESAPVDRPAPTERGASTGHGGSSGTDASGSESMPLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LST1</accession>
    <name>A0A3N6LST1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvN</name>
        <name evidence="8" type="ORF">EA462_02155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93038">
        <property type="protein sequence ID" value="RQG93038"/>
        <property type="gene ID" value="EA462_02155"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="41"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="223" mass="24237" checksum="501EBFFCA579B11C" modified="2019-02-13" version="1">MKRGLEGPPPEERPTPAGRRNKQGIRIDPEIEATHDPRRTVISVLVEHEPGVLAEASGLFSRRQFNIESLTVGPTTADDRARITLVVEEPDPGIDQIKKQLRKLVPVISVRELASDAMRRELALVKVDAERPDQVAAVADMYDAKTVDSSPETATFEITGARQKIDAAIETFGQFGIREISRTGTTALARGTDETAGRDPATAVSSADAANQSHEYTQTPTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSZ3</accession>
    <name>A0A3N6LSZ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_02685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93128">
        <property type="protein sequence ID" value="RQG93128"/>
        <property type="gene ID" value="EA462_02685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035097">
        <property type="entry name" value="M29_N-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="365" mass="39871" checksum="917DB176BE0DA7B2" modified="2019-02-13" version="1">MDERIREHADVLVDWSARVEAGDDVVLSIGPGAHDLGVAVAETLGARGANLHVTYSSGEISRAYLHAHDEEFDTTSSHELALLEETDVFLSLGGGRNTSAMADVPSRTRQSYSGARTDVREARMETRWVSTIHPTRSLAQQAGMAYEEYQEFAYDAILRDWESLAAEMERMKTLLDEGSTVRLVSSDTDLTMRIGGRSAVNSAASVAYDSHNLPSGEVFTAPTATEGEVTFDVPMTVRGESVRNVTLAFEDGSVVDHSAEQGEDVITEVLETDDGARRLGELGVGMNRGIDRYTDNILFDEKMGETVHLALGRAYDACLPEGESGNDSAVHVDLITDVSEDSRLEIDGEVAQRNGRFRWEDDFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUZ6</accession>
    <name>A0A3N6LUZ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91444">
        <property type="protein sequence ID" value="RQG91444"/>
        <property type="gene ID" value="EA462_05610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="312" mass="33631" checksum="64B58870FC0C178C" modified="2019-02-13" version="1">MNLDELRSVQSKERKKDSLQHLRPSFYQEVGEYIADLEAERDRVAETADDPFSSPEVGRLTDEIETAKDVVEAVYERRMGKLVKQASLSAAGMQADDEGLTAEESDLFDDLVTDIESNKSRVLDVLEGRESDASTGSEGHELDAGTRDGDPPEETPSEPPQPPEPETEPGVDPPLSEGDHQSDTSGVTAADVMDGETDSHTEPDPAVPPRESGESSSNPDRDADETEPDDIVAPDEPDSASGGADPAVDGADHNEITDEPSVERVTVKITRDVGSILGVDDREYRLSADDVVTLPEQNATPLVDREAAEPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV88</accession>
    <name>A0A3N6LV88_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91584">
        <property type="protein sequence ID" value="RQG91584"/>
        <property type="gene ID" value="EA462_06425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="105" mass="11265" checksum="09BAEEA2BCC1A0D1" modified="2019-02-13" version="1">MIAPASIVSALSFVLYHGYEGTEGLTGFPNIGTYLIFGVILVPVYVMVVAWFVGEPRNSKTGLMGVVYLVGITAQMWIGMFFLTMIIGLVFYGGLPEPFGVVGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVC0</accession>
    <name>A0A3N6LVC0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91624">
        <property type="protein sequence ID" value="RQG91624"/>
        <property type="gene ID" value="EA462_06650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="9129" checksum="1F2544F2FBA62ED7" modified="2019-02-13" version="1">MEYSRESVLRAGSGDVPVLSSDAVGAVTSFLSFHAGPSATRTPRVRIASELPFLRDIRVDTDGDRSCAEKPPTELSALVVSHTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LW17</accession>
    <name>A0A3N6LW17_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92997">
        <property type="protein sequence ID" value="RQG92997"/>
        <property type="gene ID" value="EA462_01945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="31"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="329" mass="36255" checksum="39A8EA460BDEFA86" modified="2019-02-13" version="1">MEPGTAIGNRDPDIGPFLARLRNPLTSRRTRIAIVADLHLSSDADGTWKLLHRTERGLETAIEDVNARDVDGVVFAGDLTASGAEREFRRFEELVEDLEAPWIAIPGNHDVRSWDGDDRSELPTASWFASSYADGSFPVVARFGGVDLVGLNSASTPDDRLTEWSGDVSDDQLEALRERLPALENPLVVCHHTLRSVPETPAAEPWEWFTLDRSEALVDVLTDHDVPLVVSAHHHLPAASVRDGLREVISPAVCSFPRAYSLLEIDERGTTIQLVPCSDREGLTEAYWHARTGEALGQGVLEMACSRLDRLPLLDEWAEDDPAASEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LW60</accession>
    <name>A0A3N6LW60_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93057">
        <property type="protein sequence ID" value="RQG93057"/>
        <property type="gene ID" value="EA462_02280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="74" mass="8574" checksum="C46CE25F1D25BD9B" modified="2019-02-13" version="1">MSTDRRSIPVSIPEGLVEELDDLVDEGQFGSRSEALRYGARLVTREAHQKRLHERAADDAEQDIEDRLERKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LW94</accession>
    <name>A0A3N6LW94_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA_ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93097">
        <property type="protein sequence ID" value="RQG93097"/>
        <property type="gene ID" value="EA462_02520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_ligase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="283" mass="32607" checksum="3E314AC2D0CD471B" modified="2019-02-13" version="1">MNYPAVPPASETPELFEEGHLWLLEKIDGAPLRFRLQQSGLIRFGDRNRWYEDPGAVPEPYQHAVRHVRANLRRDQLRTAIEDVEAVVFFGEATHKHAIEYEWDRLPSFLGFDVRSARTNAFYPPDIADQIFERIGLRPVNAVERERRARDFDPDSYTVPRSNWYDGPAEGVVIRNKRGGRATLTHPSFREAAEPPPLEQSASALATTHATRRRLESLAQTRTDRHRSVTADTLVELVLEEIVRREHDRLFLGNDSVEMAALRSAVTGQVRPFLETYWESRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWE1</accession>
    <name>A0A3N6LWE1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93157">
        <property type="protein sequence ID" value="RQG93157"/>
        <property type="gene ID" value="EA462_02845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="230" mass="26061" checksum="F39FF7B0E3F6E8E6" modified="2019-02-13" version="1">MARTRVSFSDLRTAAYCPRKCYYRRTEDDEREPPPEIEAIRALSTRYEELLEEPIAALADEPIAVSPDRYRETLIATRRRLEDDGCWTRLCAPEGRNALVTGRDCRGVVHKVLVDPLEPVLVSAGEPPERGVWESQSVHAVAAAKALGWERRTAIDRVWLEYPAYGVVRSVSLTTRRKARYRRALRTVRSLDGPPSRIANRSKCTSCEYAARCGVRTRTLRSILGFGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWG1</accession>
    <name>A0A3N6LWG1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative [LysW]-lysine/[LysW]-ornithine hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.130</ecNumber>
            <ecNumber evidence="2">3.5.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysK</name>
        <name evidence="4" type="ORF">EA462_03025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:48684"/>
            <dbReference type="Rhea" id="RHEA-COMP:9693"/>
            <dbReference type="Rhea" id="RHEA-COMP:9715"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:78525"/>
            <dbReference type="ChEBI" id="CHEBI:78526"/>
            <dbReference type="EC" id="3.5.1.130"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:52676"/>
            <dbReference type="Rhea" id="RHEA-COMP:9693"/>
            <dbReference type="Rhea" id="RHEA-COMP:13328"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:78525"/>
            <dbReference type="ChEBI" id="CHEBI:136763"/>
            <dbReference type="EC" id="3.5.1.132"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) or Co(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family. LysK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.130" evidence="2"/>
    <dbReference type="EC" id="3.5.1.132" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93187">
        <property type="protein sequence ID" value="RQG93187"/>
        <property type="gene ID" value="EA462_03025"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00039"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01120">
        <property type="entry name" value="LysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010175">
        <property type="entry name" value="LysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01902">
        <property type="entry name" value="dapE-lys-deAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="171"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="370" mass="39580" checksum="825C0AF29E026D59" modified="2019-02-13" version="1">MNASTTESADVSIEDARQLLIDLVSIPSPSGEEAKAAEHLVEFFESYGREAWIDEVGNVRAPADDAVLLTSHVDTVPGEIPVGVTPADETDLETEIADEVGEDVLRGRGSVDATGPLAAMAAAAVRTGVSFVGVVREETSSRGARHLVEDRTEPDAVVNGEPSGSNGITLGYRGFLAGTYVATSESGHTSRPEPNAIQHAMNWWTSVEAAFEQDQYQPVFERVTTKPVDIDGGISDDGLSVETTLEVQLRVPPTLDVETVRETAEASLEIGTVSWAEPIPPVMESPRTDVARAFRASIRTAGEEPRLLRKTGTSDMNIYASAWDCPMVTYGPGNSDLDHAPDERISLTEFDRSVDILDGVATTLRGGNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXC9</accession>
    <name>A0A3N6LXC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86691">
        <property type="protein sequence ID" value="RQG86691"/>
        <property type="gene ID" value="EA462_16245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="404" mass="43035" checksum="EABC5A83CF74D77B" modified="2019-02-13" version="1">MGDRTVYDDLGVPRVVNATGTKTRIGGSRIRPEALEAMERAANEFVRLSDLQANASDLISEVTGAEAGYVTSGADAGMLLSAAAAMAGNDVDAMTQLPDTSGVPAEIIMPRTHRTGYDHAFRAAGATIVDVGTNDRALGTGSTAVELWEIENAISDRTAAIGYVQKSYTEPPLSAVTDVAAKHDVPVIVDAAAELPPKSNLSRFIEDGADLVVFSGGKAIRGPQTTGLVAGRTDLIQSIALQHLDMHAASEVWEPPEQLIDLEEIDGVPRQGIGRPMKVGKEELVGLIVALESFLDSDPNALRDRWYSDAEYISKAIESVDGVETRLVAGGDTSVASEVEVHVDSDTAACSATELVRGLRSESPRIFVGADRLDEAVVTINPMCLEDGERDYVVDRVRTHLERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXY1</accession>
    <name>A0A3N6LXY1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92684">
        <property type="protein sequence ID" value="RQG92684"/>
        <property type="gene ID" value="EA462_00150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="7176" checksum="9704CFFC3CF5C97E" modified="2019-02-13" version="1">MNLPAEPITIDGIAFVLILLVLPVVSYGTMAENELVWGFGLMLLLLGSLIPLVMEFWIREDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY10</accession>
    <name>A0A3N6LY10_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86971">
        <property type="protein sequence ID" value="RQG86971"/>
        <property type="gene ID" value="EA462_15055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="321" mass="36254" checksum="DDCCF93E57BD07ED" modified="2019-02-13" version="1">MPFSVSWHTLLDELDDISDDAELITPLSHDRFHITDVQDHRVIVTFTETGDRMPLQREQFETLCRRIQEASSGFDLGRLPSDAAPYPAVLSLHPRFEIDEQTGTITEKEDATATQLVSDETATAESERVEPDGVDVYSDALLLVDALERHDVSGLSELETDALVNLYTLCSDVQRNADEFRQDVADVLLDRLHHDQSVHGQYGSVQRTLRRNRSLKDDEEVLAALEGEGIDRERVTSVDSSKIDEALEVTEISESAVYEIDESEYVRKAEVDEDVKESRLQGLKDRLTASEEEETDDLRREIEALEDRIDDLTSFSTGSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY37</accession>
    <name>A0A3N6LY37_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_17215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86208">
        <property type="protein sequence ID" value="RQG86208"/>
        <property type="gene ID" value="EA462_17215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="29592" checksum="0BD7CB36F56D5FDF" modified="2019-02-13" version="1">MHNSTVSKWGVVSAGGVSRVDCHVKVLDDTVVARARRAGFDAIVYAPHFTRLPEIRRRAAVYSSDDLLVVPAREVFTGSWHDRKHVLAIGLDEPVPDFISLDAALTEFERQNAAVLAPHPEFATVSLTAADLKRYAETIDAVDIFNPKHLRSHNRRARNLASELGLAPFTSSYAHLPRSVGIAHTEFDAEIETEADLVATLTDGVSRRVVHRNGLERVRTTARELAHLIYENTWKKADRLFLSGIEPTHPRHIAYDGRFDDVSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY66</accession>
    <name>A0A3N6LY66_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_00715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92784">
        <property type="protein sequence ID" value="RQG92784"/>
        <property type="gene ID" value="EA462_00715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="2">
        <location>
            <begin position="59"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="3">
        <location>
            <begin position="253"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="329" mass="36692" checksum="04274F253DC180A3" modified="2019-02-13" version="1">MTDLDHHRDRNHEPSTDDELSVSSVANLCTELEENVARVIVGHDDVVEHVVTAMLGRGHVLLEDVPGVGKTMLARSIATSIDCMFRRVQFTPDLLPSDVTGVNVFNQKTREFEFQPGPVFGNIVLGDEINRAPPKTQSALLEAMEEEQVTVDGDTRELPDPFVVIATQNAVEPNRTYDLPFAELDRFMKKLELGYPEPDEETELLGRTVGGHPIESLEPVTDRETIVRARETVAKVRVEEPVRAYATRLAGYTRENARVGVSPRGTIALLRAAQARAITEHREYVVPTDVKIEAPVVLGHRIRTDDRARDGDRVVEEALERVPVEAERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYA7</accession>
    <name>A0A3N6LYA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_00995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92834">
        <property type="protein sequence ID" value="RQG92834"/>
        <property type="gene ID" value="EA462_00995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025269">
        <property type="entry name" value="SAM-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13102">
        <property type="entry name" value="Phage_int_SAM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="376" mass="43436" checksum="8324631472A176A7" modified="2019-02-13" version="1">MNENIVRLLSEIDDPETIEKVLEQTDVSSMSHEKTNRNGFARATLSDLYKRFLSRRQNRSPSTRAQYKRTIPQFVEFAEDNDITNPVEISSPLVDAYVDYLQSEYDSDATILTYTKNARTWLRWLSQRELCDESIYRILDKEELGLTPRARDEAIPESEATGLLQRLRRRRRGSGMHALTEVLWNGGPRIGGVHSLDVPDFDPEKKELRFRHRPETGTRLKNGNKNSNTAGDGERNIVIKDEVISAIQLYIETERPDVTDEYGREPLFATEYGRASRSTLRRWVYEATSCRWNPKDADECSCDGSCNPDSSVCPESYYPHAIRRGSIVSHLSGGLRRERASERFDVSVKVIKKHYDPRTEQDRLNDRREAVKQSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ93</accession>
    <name>A0A3N6LZ93_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93224">
        <property type="protein sequence ID" value="RQG93224"/>
        <property type="gene ID" value="EA462_03250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018645">
        <property type="entry name" value="DUF2072"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09845">
        <property type="entry name" value="DUF2072"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="312" mass="33757" checksum="8840AAA9EA97CAB0" modified="2019-02-13" version="1">MPHECTDCGRTFPDGSKEMLSGCPDCGGNKFQFTPAGSSASDEADAEADRARKSTARNRTSTARPGDSSRTSQDQSPPSSTSTDRSDASDRPKRPGRLEKRDVSTREWPETARRPEDRSSSTADASTADSTRTPEPNPDTDVRRSDSGTDVRTSDTSAAGTADGEPPEVTEGKAQSNARSDVVSSAELPAEWTSSDPPDSSPESPAETQPETSGERPSSSAHHRDGQTPQQGAEEKSPKGGRVVSEPSDDQPSIDELREELNEQFESIKIVSPGQYELNLMGLYNREEYIISLQEDGRYVIDVPDSWRDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZU7</accession>
    <name>A0A3N6LZU7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88840">
        <property type="protein sequence ID" value="RQG88840"/>
        <property type="gene ID" value="EA462_10590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="236" mass="26959" checksum="5B3F0776DE10CCAC" modified="2019-02-13" version="1">MSRHSDLDRLYDLLNRLETNVGGKQRLKDCTGYMDWPDRGVYFFFAEDETRDAADQLRLTRIGTHAVSSGSGTSLWNRLRTHRGANSGTYEDGGNHRGSVFRKRVGEALIERDGLRDEYPHWGDGSSANRERRLAELEHERRVSEYIRDLPFLWIHVDDEPSPQSDRSYIERNAIALVSNYRKDSLDPRSGGWLGRDSPRSEISDSGLWNINHVGEEYDTAFLDRLADAVADTSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZW1</accession>
    <name>A0A3N6LZW1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87774">
        <property type="protein sequence ID" value="RQG87774"/>
        <property type="gene ID" value="EA462_12935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="26"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="286" mass="32143" checksum="3B021FE075C7013E" modified="2019-02-13" version="1">MTVHDSDTQGDQSSPGQDSDVLRVPIVGDLEPKPDPVFDNFESAIDAINRLAEDRSFDFVAGIGDVAHKGTRVQYEAATEILQDLEAPFYPILGNEELEESTDRFFEYAKTWNDDPSAIPDISYVKTANDVLFVFATASKNGKDFDEEELDWIESKLEAHEDLPAVLFVHAAPQNVFPEGRTMQTANFDRILSMPNVSAVFSGHSHMSVHETTTYARDEWENHHVHIPGIERTKVGDDHVPRFRIATIASDGRTTVETYNVDEDQFEDEHEVTFQLKRVAVESNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0G9</accession>
    <name>A0A3N6M0G9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89120">
        <property type="protein sequence ID" value="RQG89120"/>
        <property type="gene ID" value="EA462_12165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="339" mass="36396" checksum="05E7CBF1F3B90A5D" modified="2019-02-13" version="1">MVLRCSLLGHDYGESEVDREREERGSEVVVTVQEYEECLRCGERNVISENTEVTSIVTDSTGDSRPHDPDLDVDSEPPVEQTHDRTRGDGDAATGPPEADAEIVDESAAGVESPPSEKGSPPPGESSTTEHPETEDGEPITDDGEILEDDESDVGDDRDHGEWPDSDDVGPPVDTSKSSAAWPDSETEPATDTEPGEDADSVENAGSTEQRHHDQSDEGDEPIEDDEPIEDDGIVLEHDDTAHEPSTGTETVATEAEILDAGDGNDADDPAADVEAGSGIQRAESVPTPGRSSRNRSDDRTEFYCPRCDFVEGNNHGSLRAGDICPSCRKGYLGERPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M146</accession>
    <name>A0A3N6M146_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="1">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">carA</name>
        <name evidence="3" type="ORF">EA462_10315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88791">
        <property type="protein sequence ID" value="RQG88791"/>
        <property type="gene ID" value="EA462_10315"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="2">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="358" mass="38708" checksum="D7679E505468529C" modified="2019-02-13" version="1">MTAAYVALEGGHVIEGRGRSPGTARGELVFTTAYTGYEESLTDPSYEEQVLTFSYPLIGNYGVREERFEDDRVHPRAVLAKELTRDVAEWLESEGVPSIDHLDTREIVIDIRDGGAMKCGIAVGDDVTEEDALAELDRCKTMSEHTDIGAQVSVEKPTIHGADNGGPDVALVDCGAKGSIVDSLLEREATVHVLPYDTSVEAIDDIDPDVLFISNGPGDPTNYENAISLVREFVEDTPVAGICLGQQIVAEALEGTTEKMTFGHRGINQPVLDLESGRVVMTTQNHGYTVADPGDHLEITQVNVNDDTPEGLDGLEYDVITRQYHPEANPGPEDTLDFFDDVLGMTDSQTTAAVPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1Y9</accession>
    <name>A0A3N6M1Y9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89111">
        <property type="protein sequence ID" value="RQG89111"/>
        <property type="gene ID" value="EA462_12115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="173" mass="18878" checksum="3EE9E3A708391575" modified="2019-02-13" version="1">MERRKILLGSGAALATVLAGCSSTETGEELSDDTDDDPSDDGASYDDGDDDYDDGDDHDEIPGFDGGIETDSDKLTVTEVSRDGDSLGIAVQTEVTDTDELYKELEDVGHDLAYAISDSERFKAEVDVIELYLERDGAHVVGLFIDVEWALDYLEGEISREELGKKIVDTKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M290</accession>
    <name>A0A3N6M290_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_07875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89920">
        <property type="protein sequence ID" value="RQG89920"/>
        <property type="gene ID" value="EA462_07875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031623">
        <property type="entry name" value="HisKA_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16926">
        <property type="entry name" value="HisKA_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="167"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="399" mass="44596" checksum="AAC232C84CB5E423" modified="2019-02-13" version="1">MAQTNRFGSVIDGRTVIFVLGVFYIVVAVVWGFRQLPTATPHSSVLVISAFIGGSGAVLCLGGYRLSRTDIDRRFYATIARWCLGGIVVMSLILVLYHVQPTVELSDPVRSVSILTGFSSVAGFGVGVYDAKANTRALELERQNRRLEKTREELSASNERLEQFASAASHDLQEPLRMVSRYLHLIENRYRDDLDEDGEEFLEYAIDGAERMTRMIDALLEYSRVDTRGEEFEPVDLSEVVSDVREDMVVRIEETGAQIAVDELPRVDGDRSQLRQLFQNLLSNAMEYSGDDRPRIEISAERERTDDPSGDRWILSVRDHGIGIDPADQERIFEVFQRLHSHEEHPGTGIGLALCSRIVERHGGEIWIDSALGRGTTVSFSLSAVSRHRSVSGSPSQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2C5</accession>
    <name>A0A3N6M2C5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribbon-helix-helix protein, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_08100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89960">
        <property type="protein sequence ID" value="RQG89960"/>
        <property type="gene ID" value="EA462_08100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHH_1" evidence="5">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="NikR_C" evidence="6">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="130" mass="15012" checksum="CA61ABA7C7408A60" modified="2019-02-13" version="1">MRTSLNIPEEMLAEFDRTWQAEGLDSRSRALREAIQEYVESHHRLETARGTVAATIVFDYVHDEIIGELHELQHEFQAEIDTTCHVHHGEWCLETIFCHGSADDIRSLVYQLKDFDAVSRVSVTLLRSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2F9</accession>
    <name>A0A3N6M2F9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89990">
        <property type="protein sequence ID" value="RQG89990"/>
        <property type="gene ID" value="EA462_08260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="517" mass="57896" checksum="36073D02A3BE7C84" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4N5</accession>
    <name>A0A3N6M4N5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90201">
        <property type="protein sequence ID" value="RQG90201"/>
        <property type="gene ID" value="EA462_09440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="269"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="594" mass="66235" checksum="4076C5DCE62D38FB" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4Y6</accession>
    <name>A0A3N6M4Y6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90311">
        <property type="protein sequence ID" value="RQG90311"/>
        <property type="gene ID" value="EA462_10060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="131" mass="14763" checksum="3C7BFA15315A5090" modified="2019-02-13" version="1">MNEYDYESRLEVRLRDIDFMGHVNNAVYATYLEQAREAYFRDVLGVSLVDVGTVLVNLEVDYVHSIDADAEVTVALGVPELGESSLPIEYEIRADGDRAATARTVQVVVDPETGESRTLPTEWRRRIDRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5C2</accession>
    <name>A0A3N6M5C2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87919">
        <property type="protein sequence ID" value="RQG87919"/>
        <property type="gene ID" value="EA462_13735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="316" mass="34752" checksum="703F4CDECA7F31E7" modified="2019-02-13" version="1">MELAIQTAPIGGSMETKLEAASELEVSVVSLGTYDYYGPGPAELDPGTHLDDPDARETLEDQLERHEISIGMLGGGSNPLHPNPDVAENCKREITATLELAERLGVDTVSCHSGLPAGSPDDETPNWLTMPIPPEPHISEGYEYQWEEVAIPFWREIADEAEERGVDVAIEVHVNTLVHTPAKLLRLREETNDRIGAKLDPAHLLLQGMDEIDAIRRLGREDAIHAFEASDIKLDEANVRRGGMLDVPQSERRIDRSWEFRAVGRGHGSDYWRDLVDSLEKVGYDGIVSIQHLGVPEETRAGFETAVGVLDDALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7Z0</accession>
    <name>A0A3N6M7Z0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91471">
        <property type="protein sequence ID" value="RQG91471"/>
        <property type="gene ID" value="EA462_05780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="110" mass="11852" checksum="B6BFC709AF6C7C4D" modified="2019-02-13" version="1">MTEYTVEFVGTGETITCSETETVLSRCLEEGIAQEYSCRVGMCLACSAEILEGEVTQPAARAFTEDEAEHYALTCMARPQSDLKLERGVYPPSIEGDLETTGGETAAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M996</accession>
    <name>A0A3N6M996_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HGPRTase-like protein</fullName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May catalyze a purine salvage reaction, the substrate is unknown.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92850">
        <property type="protein sequence ID" value="RQG92850"/>
        <property type="gene ID" value="EA462_01095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01467">
        <property type="entry name" value="Hypx_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026597">
        <property type="entry name" value="HGPRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="44"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="189" mass="20533" checksum="2AA30962BE42022C" modified="2019-02-13" version="1">MDQLQRSLLEAPIVEKNGYHYFVHPISDGVPKLDPGLLREIVIRIIRKAKLDDVDRIVTPAAMGIHISTAVSLMTDIPLTVIRKRQYGLEGEVAISQETGYSENEMYINDVYEGERVLVLDDVLSTGGTLASVLEALDAIGAEVVDTIAVIKKVGGENKVDDAGYDVKTLVNVDVVDGEVVIVDENGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MA84</accession>
    <name>A0A3N6MA84_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1684 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93230">
        <property type="protein sequence ID" value="RQG93230"/>
        <property type="gene ID" value="EA462_03280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012467">
        <property type="entry name" value="DUF1684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41913">
        <property type="entry name" value="PTHR41913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07920">
        <property type="entry name" value="DUF1684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="199" mass="22857" checksum="EA2CB3DD73443D4C" modified="2019-02-13" version="1">MTDSSEVDAEAEFDVDQWQTELEDKRTEKDEFFTEHPQSPIPPERRESFEGLEYFEPDPAYRVTATVETDEDPAVVLMETTAGREMRYLRVAALEFDLERGDGELRDGTFELAAYQLESPNEEPLFVPFRDKTTGQQSYEGGRYMELASDRTLADGDEIVVDFNLGYTPFCAYSETFDCPLPPEENWLEVTIPAGERFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MAC2</accession>
    <name>A0A3N6MAC2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4179 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_00630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93280">
        <property type="protein sequence ID" value="RQG93280"/>
        <property type="gene ID" value="EA462_00630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="3">
        <location>
            <begin position="165"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="386" mass="40780" checksum="E1A7B14D01D2D0E5" modified="2019-02-13" version="1">MSTRSTFDTLKRIVGILIAIAIVLAAGIIVGQAPAIFGVEQDLEASIEFEDQRGDGTNVTIDEVSVSDGGFVVVTDGGSDPIAVSEYLASGTHENVTVEVDEDDEPELIGQLTATVHRDTTDDETYAYEETDGQEDHPYQEAGFPVSDTATVTTTGDDALTDSFLVESLETPTQALTNETIEITAEIRNPTDRETQQSIDFRVGGTVIEQQALELDGGESREVTFEINTTGASPGEQTIGVYTDGDGAIETIELEFHTDPAVDVVDAADENVTTEVAIPADGFVAVEDNESLIGTSEELGPGEHENVTVALEESVDDDDELTAVLYEGDPEAPDEASAIEHDNETVEVEFTVADVQSGANEEGSDASAADTDDANADGSADTESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MB39</accession>
    <name>A0A3N6MB39_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92671">
        <property type="protein sequence ID" value="RQG92671"/>
        <property type="gene ID" value="EA462_00075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="77" mass="8107" checksum="D32A90084CEB7DCC" modified="2019-02-13" version="1">MMGHYTIRARDSRLPGLTLKGFALICHAVAGLSVEHARSRVPLVVGVHREAVLAGSFAKATLLAHESASTESARSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCH8</accession>
    <name>A0A3N6MCH8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWIM zinc finger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_03110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93201">
        <property type="protein sequence ID" value="RQG93201"/>
        <property type="gene ID" value="EA462_03110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="213" mass="23309" checksum="51786CD227ECEEAC" modified="2019-02-13" version="1">MKTLASPKAPLPVPESDHLTERSRRARAEPMSVLPLGDGLYEVESASERTYLVDLEAGRCTCPDHVFRGVRCKHVRRIAIEITAGRTPPPGEIAVPCRDCGETTFVDEDTHEPYYCEQHILQSGDTATDRETGARLTVVDVSEYRADAVRVRATDDTVAQYETNAAYDPDVPVVAAIYPHASVKPNGVVPSSLTVYAFPRTRLEAVSGSNRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCI8</accession>
    <name>A0A3N6MCI8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91446">
        <property type="protein sequence ID" value="RQG91446"/>
        <property type="gene ID" value="EA462_05620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="158" mass="18307" checksum="28CBD701A7642069" modified="2019-02-13" version="1">MSVNIDSRVVTPGSDDFVDEAWQLKEDIKRREGVLKQRYDFFTDAYRRSTVHCYLQEGELVGFAAVRRDGYILFLAVDRDCRGLGIGKQLVALVADDHDTITCHARTNNENALEFYEHLGFEIKRRIDDYYEDDGDAYYLKLGPDVGITDRLSELMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCN7</accession>
    <name>A0A3N6MCN7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">DNA repair and recombination protein RadB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">radB</name>
        <name evidence="6" type="ORF">EA462_05965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic RecA-like protein family. RadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91506">
        <property type="protein sequence ID" value="RQG91506"/>
        <property type="gene ID" value="EA462_05965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00350">
        <property type="entry name" value="RadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011939">
        <property type="entry name" value="DNA_repair_and_recomb_RadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003336">
        <property type="entry name" value="RadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02237">
        <property type="entry name" value="recomb_radB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="5">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="242" mass="25880" checksum="B8D2E639AA016939" modified="2019-02-13" version="1">MPVVNDEAIPTGCTPVDELLGGGFERGAVTQLYGPPAAGKTNLALSAAVATAVDGGTVVYIDTEGVSVDRFEQLLAAQCEPGDESTAIETVASRIVIEDALDFEEQAEAVRDAEGFAERADLIVLDSATGFYRLERTADGDDGEALRRVARQVTHLLSLARKHDLAVVLTNQVFSDPDSDRTRALGGNTLEHWTGVVLRLERFRGGNRRATLEKHRSKAVGESAQFRITDAGVDGGETASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCR9</accession>
    <name>A0A3N6MCR9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93301">
        <property type="protein sequence ID" value="RQG93301"/>
        <property type="gene ID" value="EA462_01880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043931">
        <property type="entry name" value="DUF5779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19091">
        <property type="entry name" value="DUF5779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="96" mass="10352" checksum="0090884728B262AE" modified="2019-02-13" version="1">MSDFDLDLRTVEEHIDEELDLEGSIVLGILDGTTPPESWLEAISSGNALVLCVEGDVNELAAGFARDVRESGGNLVHFRGFLLVTPPGVDVNTDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MG53</accession>
    <name>A0A3N6MG53_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92906">
        <property type="protein sequence ID" value="RQG92906"/>
        <property type="gene ID" value="EA462_01405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="147" mass="16236" checksum="5698CB395C8659FF" modified="2019-02-13" version="1">MGVTGSGDDGHRVSEDSGATVPLEQLPLHSTNLLTVLDEDATIRYESPSIERVFGYEQRTLIGDALIHYIHPEDRERVMAAFHTIVDRDGDTVETVEFRHRKADDTYTWVESTGSANPTPNGNRRYSARINASSSSRASSATICAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGA7</accession>
    <name>A0A3N6MGA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92976">
        <property type="protein sequence ID" value="RQG92976"/>
        <property type="gene ID" value="EA462_01815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="87" mass="9138" checksum="9CF32CB85DD76F55" modified="2019-02-13" version="1">MMKLANSIFAQSAARGVLPMLYAASAPRADGGTYYGPGGPLNMRGTPTRQTSSDDSRDEAGAERLWTKSESLTGVSYEFDALSSDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRB8</accession>
    <name>A0A3N6MRB8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86803">
        <property type="protein sequence ID" value="RQG86803"/>
        <property type="gene ID" value="EA462_16335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="74"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="304" mass="33311" checksum="497E3363F68820F4" modified="2019-02-13" version="1">MDPQMETVIDEIEEMGLPNWHAMSIQCARRIEDDVFSRGEGATVKSVRDFEIEGKGRPIPIRVYHPGVENPPTLVFYHGGGWTLGTLDSADNICRELASRSDCLVISVDYRLAPDHPFPAALNDAFSALTWAANHANEFGADPDRVGVAGTSAGGNLAAAVALRTREADVSLGGQFLLYPITDVVRGTESYTEHADEPLLTRRDMEWFWEQYLEDPVQKYNPLAAVGRVADPSGVASAVVLTAGFDVLRDDGFEYVQKLLENDVPTTHEHYPTLAHGFLSVTDSVDEANEAMNQLADHIQSQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MS71</accession>
    <name>A0A3N6MS71_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KEOPS complex Pcc1-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87073">
        <property type="protein sequence ID" value="RQG87073"/>
        <property type="gene ID" value="EA462_15690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="88" mass="9667" checksum="FBCE20948B68C71C" modified="2019-02-13" version="1">MTSHDATLEFEYGCASTARTVAESVRLEIGDIDDDRSRTAIERTDSTVRLEVAADDAVALRAALNTWFSLVDVAEQAGTLGEYTLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSZ5</accession>
    <name>A0A3N6MSZ5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_13615</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87895">
        <property type="protein sequence ID" value="RQG87895"/>
        <property type="gene ID" value="EA462_13615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG87895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="553" mass="60304" checksum="31D3E3ECFCF51150" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUD8</accession>
    <name>A0A3N6MUD8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88992">
        <property type="protein sequence ID" value="RQG88992"/>
        <property type="gene ID" value="EA462_11430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="216" mass="24421" checksum="1E19EB355034568C" modified="2019-02-13" version="1">MSPPILFDMDGVILEGARTPLSVYRDATGDALVDLGVEPSPDQRRVLDGHDIERITDHSHDLGIDPVRYWKLRERYASERTHDRIRSGVRGLYDDVDAIADLGERTSISLVSNNRQQTVEFVADYVEVEFDVVRGRDPTFEGFRRRKPNPYYIEESLAELGAETGIYVGDSQTDVEAGHAAGLETALIRRPHNRDLECPDPPTEELESLRELLDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUE6</accession>
    <name>A0A3N6MUE6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thymidylate synthase</fullName>
            <shortName evidence="4">TS</shortName>
            <shortName evidence="4">TSase</shortName>
            <ecNumber evidence="1 4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">thyA</name>
        <name evidence="6" type="ORF">EA462_11490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1 4"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89002">
        <property type="protein sequence ID" value="RQG89002"/>
        <property type="gene ID" value="EA462_11490"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="5">
        <location>
            <begin position="3"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="192"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="338" mass="38481" checksum="7C16746636A911C6" modified="2019-02-13" version="1">MRQYLELVDAALSGGNYKSNRTGVDTISSFSEHYEVDLGEGYPLLTTKRMDGYRWNSMIHEVCWYLSGDEHIRDLREETKIWDAWADDRGRLDTAYGRFWRRYPIPEDAARLEGESWPDEAHRWVTTEADGRRTFDQLQYVIDTLSDTPNSRRLAVSAWHPANAAVSTLPPCHYTFVFNVQGDRLNCHLTQRSGDIALGVPFNIAAYALLTEVIAGQTGYEPGTFAHTVVDAHVYCGTDARGEWYADNLETFQARLEAVDGREGYRTLREWLESEAPDEADGEDRLDHVPGLLEQLSREPLERPKLEVADVSIDELTAEDVQLRSYDAHDGIRFSVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWL1</accession>
    <name>A0A3N6MWL1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89872">
        <property type="protein sequence ID" value="RQG89872"/>
        <property type="gene ID" value="EA462_07610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="63" mass="6606" checksum="EC73FC2CAD3BD1D6" modified="2019-02-13" version="1">MKFDLAKTTVAFALIVALGAAALLVTPMMAVDTVLMMVVPSMIVFGAIALVIGVKHGEYRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MX52</accession>
    <name>A0A3N6MX52_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="1">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_08715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90072">
        <property type="protein sequence ID" value="RQG90072"/>
        <property type="gene ID" value="EA462_08715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="146"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="438"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="444"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="476" mass="51581" checksum="2A1A92A173598A1A" modified="2019-02-13" version="1">MQHHTQTIWNDSDSAGYEPLLSERNMDTVEVDGTDLPDHLTRDSLELPELSEPELARHYTRLSQMNYGIDSGPYPLGSCTMKYNPKFTEDVASLPSAAVHPDREEDSVQGTLQIYHELQEYLGRIGGMDAVTLQPPAGAAGEFAGILVAKAYHEANDEGDHRSEVIVPTSAHGTNFASAAMAGYDVVELPENEDGRVDLEALSAAVGESTAALMLTNPNTLGLFERNIEEIATIVHDAGGLMYYDGANLNALLGRARPGDMGFDIMHYNVHKTFATPHGGGGPGAGPVGVCERLAPFLPTPQVRENDGEYELFEPDETIGKVHGAMGNWLVLLKAHAYIRRLGGDGLRDASAKAVLNANYLASQIDLEIPFEPFHHEFVASAGDRDAADFAKRMLDYGVHPPTTKWPENVTEALMTEPTEAESKATLDQLADAFAAASTDDVSELENAPRQTSAGRIDQTSAARNPRLSWQQLDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXJ6</accession>
    <name>A0A3N6MXJ6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P protein component 3</fullName>
            <shortName evidence="5">RNase P component 3</shortName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Rpp30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnp3</name>
        <name evidence="6" type="ORF">EA462_09620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90232">
        <property type="protein sequence ID" value="RQG90232"/>
        <property type="gene ID" value="EA462_09620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00756">
        <property type="entry name" value="RNase_P_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023539">
        <property type="entry name" value="RNase_P_comp-3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="234" mass="25661" checksum="CCDBFB9853B7995C" modified="2019-02-13" version="1">MYEAVHAQPDGESTVATLVETAAAYGFEGVVVRNHSNARASYDATELRAEHDIDIVRGVEIRAENPQHASGAVGNFRTDETIVVVEGGTNDLNRFAVENEKVDVLAHPMANGGDVNHVMAKAAVENGVRLEFSLADVLRDHGGHRVRVIQSLRKLAEIVDYYDVPYVVSADPFSHLALRAPRELRALGDAIGLSSTFVEDGLDEWGRIATRNRRIQSESFIEPGVERGRYEADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXQ0</accession>
    <name>A0A3N6MXQ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90302">
        <property type="protein sequence ID" value="RQG90302"/>
        <property type="gene ID" value="EA462_10010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="150" mass="16390" checksum="8513CC9B7E604B09" modified="2019-02-13" version="1">MYDRLLLPTDIGTGVDRAIDHAIDAASRYDAELHVLYVVDTETYGSYPGDEYVHELEGLESALEQAGRDAVEEISETAADEGIDVKTSIEHGVPHGAILEYVSREDIGLTVVGSKNRSGEYRRLLGSVAERVANMSDRPVTIVKTPVETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXU0</accession>
    <name>A0A3N6MXU0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteasome assembly chaperone family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90352">
        <property type="protein sequence ID" value="RQG90352"/>
        <property type="gene ID" value="EA462_07590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="247" mass="26835" checksum="46DC245B5CC07CDE" modified="2019-02-13" version="1">MAQIRVQGPEADLEEPTIVEGFPGVGLVGKIATDHLVSELDMRYYASVHCEGLPRIGVYRGDERSVRPPVRLYVSEEHDLLALQSDAPVSAQAVENVADCVTSWIVEQDATPIYLSGLPDEREDDRPSLYGISTGEAAETLETHGVAVPPEDGVVTGPTGALINRAAQLEYGCLGLVVECSPQFPDPEAASVLLEDGIAPIADVSLDVRELVERAEEIRKKREQLAQQMQAMGQDESTQAQPLRMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4H4</accession>
    <name>A0A3N6N4H4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M48 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93082">
        <property type="protein sequence ID" value="RQG93082"/>
        <property type="gene ID" value="EA462_02435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="30"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="240" mass="27974" checksum="4DC1D5468A3B97CE" modified="2019-02-13" version="1">MADPESREIELLGNSIEYTVRCSSEATEPRIDVDIHGVTVVIPDSGETRPPELLRENAAWVLEKNRKYDSYRKQVPERRFNEGETFPYLGEQHEVVVEKRPSSDVADGTLLLAKHHVEDTSVKRALETLYRRKAREWFEEWADQYAAEMGVEYEQIEIRNQRTKWGSCSTTGTLGLNWRLMMAPQDVIDYIVVHELAHLRESNHSEEFWSLVAEHDPEYKKHAEWLEANSTQLIFSKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUT8</accession>
    <name>A0A3N6NUT8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86980">
        <property type="protein sequence ID" value="RQG86980"/>
        <property type="gene ID" value="EA462_15120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="158" mass="16861" checksum="D65A86EE3548FF92" modified="2019-02-13" version="1">MYDRILVPTDGSPEVEHALEYAFDVARAHDAVIRAIYVVNAAGYGGLPMETAWEGISKALREEGRAAVERVEQLAPESVEVETAVLEGSPSRVIIDEATPSSCDLVVMGTHGRGGIDRLLLGSVTERVVRSAAVPVLTVNVDPNKIDDGVDQPQVAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWF1</accession>
    <name>A0A3N6NWF1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_10745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ModE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88869">
        <property type="protein sequence ID" value="RQG88869"/>
        <property type="gene ID" value="EA462_10745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016462">
        <property type="entry name" value="ModE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005763">
        <property type="entry name" value="Txn_reg_ModE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Mop" evidence="6">
        <location>
            <begin position="161"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG88869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="234" mass="25298" checksum="3AF95095BA7ED7D8" modified="2019-02-13" version="1">MTIEREYSTKLSVDGVTIEQRDIEMLDAIDQYGSMHKAADALGRSYARLQNRVVEIEEAVGTITERQRGGSGGGGTKLTQTARELRQQFDRHEAELNGVAQVTESVFTGTVRDRSGELATVDTDIGSVLALVPEETSDVQISVRSDAVVLTDPDEAPQTDGTSLRNQFTGTVDEIEPGDAIVRVSIRLGADSTIQALITKTSSERLALEPERTISVSFKATAARATSIESPTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX92</accession>
    <name>A0A3N6NX92_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89289">
        <property type="protein sequence ID" value="RQG89289"/>
        <property type="gene ID" value="EA462_12000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="118" mass="11991" checksum="ED420C3067061871" modified="2019-02-13" version="1">MVLASAVVFLASLLIGALGIYVGARVIVGAGDYDHAIVTALIGAIVWAVVGFFVGWIPLLGPLLALVAYVAVVNVRYPGDWTAAAMIGLVAWVTVLIALYVLAAVGITGFDAIGVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYU4</accession>
    <name>A0A3N6NYU4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86646">
        <property type="protein sequence ID" value="RQG86646"/>
        <property type="gene ID" value="EA462_15985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="196" mass="22063" checksum="264D2A767F2F3695" modified="2019-02-13" version="1">MSAIPPWVDERIDRNLDNTLTQEHVVETMLESDRPFFSIRQLHACIKPDVTRATVRNRLRELQEIDVVATETYPDSITLYYINHPESAWPLSPEGKRALHAETPLDRLSTRGFLTLSDTAGIRTLVLAGFQLSLVLFALGGVLTVAGTDVRGTQSDIVLWDTGFDLLFVSLLLLFAERTARWVRDRYGPLSLLPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZA6</accession>
    <name>A0A3N6NZA6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90259">
        <property type="protein sequence ID" value="RQG90259"/>
        <property type="gene ID" value="EA462_09775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043899">
        <property type="entry name" value="DUF5789"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19102">
        <property type="entry name" value="DUF5789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="94" mass="10270" checksum="014775D914C8EF85" modified="2019-02-13" version="1">MSDDEDEEPAVSLGEHTPVEGAPLARVTSRLTWPKEKSEIDRLEGESVVRTPDGPTPLSSILEDVDETYFQRSQEFEGCVRAVIGTGPIPTADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZM0</accession>
    <name>A0A3N6NZM0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87016">
        <property type="protein sequence ID" value="RQG87016"/>
        <property type="gene ID" value="EA462_15335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="164" mass="18557" checksum="BAE02B39FDBECEBB" modified="2019-02-13" version="1">MSMGQRVSSDHQLARLLQIGVVLEEVVESRAAHHLESLPPEQRDAVDDEIRELLVEAASESADHRERLEALIDDLDAETVAYEEINALVDAQYGPPEDTDGVLYDQLCNEETAYKFYDDLIDAIEASDVEFAIDRDRLLETLSEIRTEEKEGAEEVTEIMEHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P061</accession>
    <name>A0A3N6P061_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_12960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87778">
        <property type="protein sequence ID" value="RQG87778"/>
        <property type="gene ID" value="EA462_12960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="76"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="261" mass="28800" checksum="571438387FEDB33D" modified="2019-02-13" version="1">MSEPNKPTSETEPRTVGAVQTTLDIIDLLHHNDGAGVTELSTELGLSKGTVHSHLATLYKNEYLIKEDDEYNLSLRYLHLAETVRDRLGFYDVVREEVDELAQESGELSQFATEEHGQGVYIYKASGEKAVKTASSVGKREYLHCTSLGKAMLAHYPESYVDGIIDQHGLPGFTSTTITSRDELFDTLEEIRNRGYAIDNEERIDGLRCVAAPVLNNDGSVLGAVSLSGPSSRMIGERFDEELPSMVVRAANVIEINSQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0F5</accession>
    <name>A0A3N6P0F5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UbiD family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87948">
        <property type="protein sequence ID" value="RQG87948"/>
        <property type="gene ID" value="EA462_13885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="584" mass="65226" checksum="D6D61088A64132E4" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0K1</accession>
    <name>A0A3N6P0K1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88018">
        <property type="protein sequence ID" value="RQG88018"/>
        <property type="gene ID" value="EA462_14275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="316" mass="33475" checksum="47508BF934D6E8F2" modified="2019-02-13" version="1">MPENLWLSFAFLAASIYATLSLVDKIVLDRDSTGPISTTALSGFSMMATFIVAGIMTQNTGFESTTISSELLLAMGIGILGGFAYVLSLWTYFIGLEKSEVSRFIPLLSLDLIIVLVLAFVLLGEGFQPVVYVGVFVIFLGTVLISLDNASLTAGFKSKQALFWGLLVAGTTAALQLILEFMTAHLSLFGIMFWVGIGGVFSLCGLLAWKLVQAGRLPSGAFESAVSAQGGVLLIRGGFIAIAYYAFVLALETGPVSIAVAVLKLDVFLVFFGALVLSKIAPAILHEPTNRRILVQKFTASGLIVGGVVIIQTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0W3</accession>
    <name>A0A3N6P0W3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AbrB/MazE/SpoVT family DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91109">
        <property type="protein sequence ID" value="RQG91109"/>
        <property type="gene ID" value="EA462_03675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="52" mass="5807" checksum="4B043729DE347D80" modified="2019-02-13" version="1">MGRLADTKVSEKNLTTVPKPVRNFLDVGAGDRVEWHVEDGRIIVEKQSTTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P190</accession>
    <name>A0A3N6P190_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S26 family signal peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88825">
        <property type="protein sequence ID" value="RQG88825"/>
        <property type="gene ID" value="EA462_10510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="376" mass="39927" checksum="13DD3C9A6314A122" modified="2019-02-13" version="1">MRLRRLLRVTFAVVIVLTLGSLLLGAMLGQPILLSYTETGSMDPTIAEGDGFVVIPSTGLGSAEVGDVVIYDAQEANEGGLTTHRVVGATDHGYETAGDANIVTDQDGGEPAVTDGQIVAKAWTVGGDVVTIPHLGTVVMNIQSGIDSIRDVLGIGPRLGSQGIATLLFGVGVALLAFTFLTKSRSRHRERTRSRRTSVSARGIVFGLVVCLCIVTFGTMLAISGSTEFGTVSADYESDAPHVIQSGETGERNYERHNGGLLPVVSILEPASQGVSVEDEPTQLHHGESANTTITVTAPTERGYVLHAVSEFRYLAVLPPPLLEMLHDVHPWIAMTSVTAVVVSLFTLPFALLLGTGRIVLRERKSGGHTHDYLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1E3</accession>
    <name>A0A3N6P1E3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91309">
        <property type="protein sequence ID" value="RQG91309"/>
        <property type="gene ID" value="EA462_04810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="166"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="225" mass="24802" checksum="134A7C7F11BAB156" modified="2019-02-13" version="1">MRYATVVLTWTADELDSIDGAFARSDAVSIRAIRDLTLVDDRRYVELLELRGDLECGRSLLAGAPDALEYAVAGRNGRGHAYVTCRSVAPVTDLLAILREHEIVLDWPIAHIEPEEWAGTGCGLEVTVIGTNEAIQRAATALPEGIDLTVQRTGEYDHPGRGGPTLTPRQRDVFEVALRDGYYEIPRETTHRELADRLEISPGTVGEHLQRIERNLALSEAEFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1V6</accession>
    <name>A0A3N6P1V6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91529">
        <property type="protein sequence ID" value="RQG91529"/>
        <property type="gene ID" value="EA462_06100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="110" mass="12528" checksum="B7BB3AE2243C97CB" modified="2019-02-13" version="1">MKGRHDIIASEWDNLILLDACRFDMFQTASDIDGSISKTISKGSTTKEFLENTFSNAEYYDTVYVTSNPQYVNVGLNDVFHAVIDVWDWGISTNWKSKLCPSDDVSTWFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3S2</accession>
    <name>A0A3N6P3S2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proteasome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_08235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89985">
        <property type="protein sequence ID" value="RQG89985"/>
        <property type="gene ID" value="EA462_08235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="165" mass="17967" checksum="E786735B3B1B383B" modified="2019-02-13" version="1">MGLLDALFRSNEILGIAEETLEFAIESSEASHPAEYMGFLRGTEAHRLELDRDGLVITDILVVPGTESNSVSATVRTSQIPNDVKALGSVHSHPNGVIRPSDADLETFGRGSVHIIIGAPYGRTDWKAFDSQGRPTNLNVIDVALPESEDFFDFTQADIDEELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P498</accession>
    <name>A0A3N6P498_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_00405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92729">
        <property type="protein sequence ID" value="RQG92729"/>
        <property type="gene ID" value="EA462_00405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="181"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="309"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="416" mass="47288" checksum="98BC6805050B848A" modified="2019-02-13" version="1">MAIEVTRTYVGSIQNQRQVCDGLDLLGDAASKIWNVARWTADRIWDATGEVPDESSLKAYMKNQPCWKDLNAQSSQKVIEELSDAFQSWFDLRQNDLEANPPGYRKHGDKRPKSTVTFKADGFKHDPENNRVRLSKGSNLKETWADFILCEYQARPDVDLTEVNTVQNVRAVWNGDEWELHFVCKVELETNDSAGDGVAGIDLGIKNIATVAFPDEYVLYPGNSLKQDKHHFTRAEYDTEGENGPSEKSVWARRKLTERETHFYHVLTDTIITKCVERGVGTLAVSWPEDVRESDWGKIGNKKLHSWAFDRIYQYLAYKGETRGVEVLKENEWDTSKTCSRCGDDTRSNRVERGLYVCSSCELVANADCNGAENMRQKITPSPHGEDRSNGCVAQPSVHLFDRESGMFRTREQIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6R5</accession>
    <name>A0A3N6P6R5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91545">
        <property type="protein sequence ID" value="RQG91545"/>
        <property type="gene ID" value="EA462_06185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="131" mass="14439" checksum="13C7690EFA78C62B" modified="2019-02-13" version="1">MVEDRITDGRRIAQLLASELDGREDGELDAVAVTNVDRDVEPSADGARAYDVTRVRDGSESGRLARVFVHEDRVRLEFEIEQEIAAEAGEAVELRVRPKASDPPRTLVFVESAAAVKRATDVVQAVLQERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9J9</accession>
    <name>A0A3N6P9J9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TackOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92915">
        <property type="protein sequence ID" value="RQG92915"/>
        <property type="gene ID" value="EA462_01450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040572">
        <property type="entry name" value="TackOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18551">
        <property type="entry name" value="TackOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TackOD1" evidence="2">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="333" mass="36905" checksum="E5CBC17CD92B99FC" modified="2019-02-13" version="1">MSRLQDGTHDAFDPVIDETGDVSYPPVEHHLDQRDGKAIDFLRAMADRGVLSSEFEYKVYVCPDCSAEGMQYTTGCPHCESVHATREAAVVHPVCGETLGTDPRADADNTVEGQDEERADGQESLYCQNCDEELPPEDLKRDHQYRCHGCNAGFDSPTHRLWCWDCRHTCPPTDAREQPLYRYRLTATGDRWVVEQVDGRRSLAETFEARGYETAVDTTVPTSSGDERSVHVYAEDDLLDDRIVAGVHDSPTPADVEHLVEAARETDARPVILSTDGAADERAAELLDAESVTVVRATGGELSRVHGISERSRGDNRVLEWLGSFVPSSASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9W8</accession>
    <name>A0A3N6P9W8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterio-opsin activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_02510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93095">
        <property type="protein sequence ID" value="RQG93095"/>
        <property type="gene ID" value="EA462_02510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAT" evidence="4">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="219" mass="25100" checksum="DE4ED3CF4B0F3216" modified="2019-02-13" version="1">MLIATFELEHDAVALTQAFTDEPEMKVEAERIAAHSTKWTMPCLWVASNNFDTADEALSNDPSIRRIVETTSFEEEKYYHLEWADDVEERVNKYIDQQGSILHAEATAHGWQLRIRFVSRDQFDRFRKRLTEQDHSFELLDLTEPGSPRVSFGELTPAQHNALVAAQEHGYYEVPREISARELAEKLDISHQSLSELLRRGTGKIIESTLSTQDVPADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHN5</accession>
    <name>A0A3N6LHN5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_16155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86674">
        <property type="protein sequence ID" value="RQG86674"/>
        <property type="gene ID" value="EA462_16155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="172"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="239"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="640" mass="72064" checksum="40090AEFBBF62AE9" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHP2</accession>
    <name>A0A3N6LHP2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bleomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_16270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the extradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86694">
        <property type="protein sequence ID" value="RQG86694"/>
        <property type="gene ID" value="EA462_16270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000486">
        <property type="entry name" value="Xdiol_ring_cleave_dOase_1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00082">
        <property type="entry name" value="EXTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="7">
        <location>
            <begin position="7"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="190" mass="21630" checksum="1FBEE270D87BA611" modified="2019-02-13" version="1">MVVDNMGLDHVAIKVRDIEQTIEFYTDVMNMAVSDRIGDTVAFLRTPAVSEQADHHEMNITQYSDEELDVLEQRGELELDLHEFEEDLPEGGPPMLPTTGPIYHIAFEVPNYQSIRDAADELEARNHPIYRGPGRHGPGNNIFLYFPDPDGYPIELTAKMEEAPEDGGRPARQWPQSPDTWNVWRNAEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI55</accession>
    <name>A0A3N6LI55_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86974">
        <property type="protein sequence ID" value="RQG86974"/>
        <property type="gene ID" value="EA462_15085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="148" mass="16943" checksum="21027E6BCA6679B3" modified="2019-02-13" version="1">MSTLTSSQREQELSADVILELLANRRRRYLLYALRGQENPIELSRLAERIAGWEQDVPPDEVAKNEYKSVYVSSVQCHVPKLADTGVVDHDEDNHTVVLADNFDQLEPYLRVVIQDEPENSRLHAALEAESDDGFFSQIRENVARLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI56</accession>
    <name>A0A3N6LI56_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86789">
        <property type="protein sequence ID" value="RQG86789"/>
        <property type="gene ID" value="EA462_16785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="346" mass="37481" checksum="58F863CA0FBA50B7" modified="2019-02-13" version="1">MQWTRGRLDRRLRPSLRQRRHVLRDSHRKIDLESFQLGGAMVAVRRVPPPLVADSLLSPGIGSLFLAVSLTGHPPRQENTFYTSDGTCIGMSIESDLIDVTREDRIATITLNRPERKNALSRALVCDLIETVQFLEETATRVVIIRGAGGTFSAGGDLEQSPDEFVEEVSKSIDVIDAIHTSPVPYIAAIEGAAVGGGLELALACDLRVAGVEARVGLPETTVGIFPCAGGTRFLPRMIGTTRAKELVLTGRLISGDRAASWGLVNRAVDAADVMDTASDLAEAISSNSPTAVEATLRSTNEAFDTPVIEGTRWDEELAQTVAHHPDFEEGKQAFLENRSPVFEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIE9</accession>
    <name>A0A3N6LIE9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87134">
        <property type="protein sequence ID" value="RQG87134"/>
        <property type="gene ID" value="EA462_15440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="101" mass="12075" checksum="B486254E2945586F" modified="2019-02-13" version="1">MGYNRDGDVISRFVVQLEYEIDEWTTVVRYDHDVKSEFGHDVSEEGVHIDIYRDGEKYRTEYVAPPMPAKYALDRAEDHLANNLVGFIRRFEEWHEIRPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIX7</accession>
    <name>A0A3N6LIX7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF59 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87956">
        <property type="protein sequence ID" value="RQG87956"/>
        <property type="gene ID" value="EA462_13925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="109" mass="11926" checksum="D31F8A93B7D9AB18" modified="2019-02-13" version="1">MAHSEAASTAEQCRTALEDVTDPELPISIVDLGLIYEVTHDDGHVDVDMTLTAMGCPAAQLMVEEVEERLLELSDVESVDVDIVWDPVWTKDKMTEAGKQQLQSLGISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJL6</accession>
    <name>A0A3N6LJL6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_17330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86114">
        <property type="protein sequence ID" value="RQG86114"/>
        <property type="gene ID" value="EA462_17330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="160" mass="17570" checksum="A57378E5F4837BE3" modified="2019-02-13" version="1">MSERRDEPDPTRVVADPTVLAADLFVDGDAREALDHVRRHSWVDLVASEHLLEETERLVASLADEELASDHRARLEADCVAVDHPADDHPALASAYRGEAAHLLSDDERLGSAKAGLSLQPRVSVSVRPPDAFARLFDPESLYEAVEGDEYPGPDRDPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK92</accession>
    <name>A0A3N6LK92_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89008">
        <property type="protein sequence ID" value="RQG89008"/>
        <property type="gene ID" value="EA462_11525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045940">
        <property type="entry name" value="DUF6360"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19887">
        <property type="entry name" value="DUF6360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="98" mass="10770" checksum="3673FB502F477317" modified="2019-02-13" version="1">MTGRILDVTAHTTFDYLEVQAIGNGWIDETVGVLDVESPRGKRTVTFGLESDPADLHHIEHHAESVTLTPDQARSLAEELREAASAAERGDAMSSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK99</accession>
    <name>A0A3N6LK99_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionyl-tRNA formyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86808">
        <property type="protein sequence ID" value="RQG86808"/>
        <property type="gene ID" value="EA462_16775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="1">
        <location>
            <begin position="128"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="304" mass="34594" checksum="D5460C1057F7B213" modified="2019-02-13" version="1">MDEPISVGILCEPYLYEWHVRALETLENELDVRIPLVVSNARNRDCELESWNDRKRVRLDDFEQFYDAIRREGAWSFVLAERTLARILGDEQQLWHRHTVDTVACLENAAHVRCDPSMEKGWFEFPDEIVTRVAADCDVVVLFGFGLIRGAILNAPEYGILSFHPADIRSYRGMGPPPMFHDGAEIAGTTLQQLDESIDGGKIVAYDDVDISDCYTLWDVFDRIVRVQIELLTNGISAVTRPDFEPTTVPTAQLGDLYYRETRRTVGFSGRILLNNLLGRTVRQTTRLSRHLSRLGSGPGHRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LL56</accession>
    <name>A0A3N6LL56_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_12970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87780">
        <property type="protein sequence ID" value="RQG87780"/>
        <property type="gene ID" value="EA462_12970"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="7">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="30319" checksum="B2D803568D749851" modified="2019-02-13" version="1">MISLDLHVHTTYSDGSDIREMVAAADDAGLDAIGLADHCILHEDRFRRCDRTDFDETYPERRSDIERLQSEFDVTILDGVEMNYDPAYHDEIQEFLARAQFDYTIGSVHYADEYHIAKTGWFASVDEPDRAAAVDHYVDWQLQLIESELFDIVGHLDLCERSSELRGRITDEQYDDLLEALGRSRSVPEINAGRVFDDYGAVHPNPRVIDRFLDSGVRFVLGSDAHKPTELTKRAEYLTDFTESRDLECLPFENGLSVDEALKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLC9</accession>
    <name>A0A3N6LLC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89763">
        <property type="protein sequence ID" value="RQG89763"/>
        <property type="gene ID" value="EA462_07015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="13"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="136" mass="15544" checksum="3F707593D516295D" modified="2019-02-13" version="1">MALVVVPVRYPLTKHSRRTLERALEVARDRDAALTILHVDLYQNGRKVTRIDLKEAVEGTFGPLENVRYIVRSGFLVEESILEEVAAEEADAVVIGGQQASRLRRIFRRFTDNPDINQYLRTHLDCEVITVEPSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLF0</accession>
    <name>A0A3N6LLF0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87930">
        <property type="protein sequence ID" value="RQG87930"/>
        <property type="gene ID" value="EA462_13795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="16"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="407" mass="42499" checksum="707C357847753FC4" modified="2019-02-13" version="1">MSEHASVRPNDGSDGRAGVVVAMWLLTTIGYAYIIVPTSVLPVIQESLLIGPLAASVILSITLAAQSISNVPVGALLDRMDNLHVLGWATVGLVIAGLWGWYAAASGDYWSLLGSRGLGGVVTVVMWTVGVNVTTGLYQFDRRATAIGFFTTSAPAGFALGQFTGPVVANSFGWESTFAFYSIVAGATFGFVVIASARCSSPTTPETPVPTLDEVRAVLGNDSVWLIAILAGISFSAFFVLTNWMPSYLVDEYGLSLIHSGFFVALFPAVGIASRWGGGFISDAWFAGRRRPVVFWSFLISTPTFVVLAVVREPFTTVLTLCLAGISIQLGIGVFFAYAREVADASVSATAVSITSAVAVAGATVGPVITGALFELSGTYASVFVYVILLSAAGVALSYKAPEPSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLS3</accession>
    <name>A0A3N6LLS3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89983">
        <property type="protein sequence ID" value="RQG89983"/>
        <property type="gene ID" value="EA462_08225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="463" mass="50932" checksum="DEF53469F1902983" modified="2019-02-13" version="1">MEFDPTRRRFLAGSATAGIIAVAGCSEEEEPIEDPDPSDDDGTDGESEDDGTDEEPEDDDEEEEEDEETTLQYEIWALDQGMDNVHLYQPGDGDDEFDHTNTIDLNELEGVPDEGVVPHMIDYSSDYEYAAIACTAGARTLVFRTEDHELVGNIETGPSSHMAAFSPDDEYIHVDVIGDRKIVRVDADLEAEEFSIEDDIDLNENEAILDAGIDSGSPICHQYAHDGRSLHTVGPSYHDGALIIVDHDDFSVDQAYSGDELPTNCGTMPHPSEEKFYLTAGLPSDPEEDEEGVGDFYVYDTEADEIAVDGESTEGIDAHGFWFTPDGEELWVLNRETNDGIVLDPETDEVIEEIDAYGENQSEDSSERDSPDIMWSSPDGQYMFVTLRGPAPQSGDPHAATGVIPGFSVLDTETREIVDVVEPDPIENYDQDDIDAEEVPDFHGIGVRPIDDFETGIPTSPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLV8</accession>
    <name>A0A3N6LLV8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">mutS</name>
        <name evidence="11" type="ORF">EA462_07760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89898">
        <property type="protein sequence ID" value="RQG89898"/>
        <property type="gene ID" value="EA462_07760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="10">
        <location>
            <begin position="767"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="693"/>
            <end position="700"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG89898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="945" mass="103338" checksum="B1B57601A127679E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM09</accession>
    <name>A0A3N6LM09_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86101">
        <property type="protein sequence ID" value="RQG86101"/>
        <property type="gene ID" value="EA462_17255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="111" mass="11795" checksum="5E75491A32419A6F" modified="2019-02-13" version="1">MTVTGDNHDGRRIDSQAGTALLSHDWNEGDSLANAIVSAIATLSGRTPDEMERLYDRIDPDSLEAIFEPTNGTTNRADGTLSFRLEGYAVIVHGSGTVLVAKNGRGEPGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMA5</accession>
    <name>A0A3N6LMA5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF92 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_11015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88917">
        <property type="protein sequence ID" value="RQG88917"/>
        <property type="gene ID" value="EA462_11015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="PTHR13353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG88917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="443" mass="44797" checksum="8459AAB61A1F1763" modified="2019-02-13" version="1">MTTPIRRAAVFAAICTLSLAVPLSGPGTGAVLAAVVLLGAFVVTEGPLFDLLAYPGDYEDGRLYGLITFVLAVVALGLIAVMSSMSIAVFVGTAFLIGYGNVAEQIARSRTDDEVVVATVFALVATVGAVVGQAATHAIDGVPIEPMVPTIVFLAATGALLAALLRDVLLLYDDPIVMVSVGLLLWLLAELEPAIGPLEIVAALVVTVALGYVSYVLDTASIAGMVTGILLGLVTIVLGGYGWFAVLIAFFAIGGLSTKFRYDRKEDLGVAEDNNGARGTGNVLGNAAVALVAVLGYAASSAGLFPGNPDPILFLFAFTGSVATAMSDTLSSEIGSVFETPRLITTLERVEPGTDGGVTWQGELAGLVGAAIVAGISYALFPEVDATGAAIIVAAGFVGMTVDSLLGATLEGTVLGNQGVNFLATLSGALAGALLVLSFAVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LML7</accession>
    <name>A0A3N6LML7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90383">
        <property type="protein sequence ID" value="RQG90383"/>
        <property type="gene ID" value="EA462_09600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="69" mass="7077" checksum="7AE71AE23B0FB59D" modified="2019-02-13" version="1">MFVAIAGVGLVALGLAGVRYAPAIVAAQHRQGMTPVEDDAISGTDRIRVTKGTGLVVASLGVVLLAYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP22</accession>
    <name>A0A3N6LP22_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF302 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91163">
        <property type="protein sequence ID" value="RQG91163"/>
        <property type="gene ID" value="EA462_03980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016796">
        <property type="entry name" value="UCP021774"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021774">
        <property type="entry name" value="UCP021774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="53"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="154" mass="17150" checksum="668AD122B9675F09" modified="2019-02-13" version="1">MGTSLPIDPSEIDPDDIGEKQAVLEMAHEDAIEHVREVCEETGFGIPVEFSPSELLNEKVDADRDPYYVLGACNPEIADRTLEETMRMGGLFPCNVIIWEEEPGKQRVYHVSIMKIARLVGIAPDNDVWDEIVDTTGDLTAEAFERLDTVDTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP52</accession>
    <name>A0A3N6LP52_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease J</fullName>
            <shortName evidence="4">RNase J</shortName>
            <ecNumber evidence="4">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rnj</name>
        <name evidence="6" type="ORF">EA462_04225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91203">
        <property type="protein sequence ID" value="RQG91203"/>
        <property type="gene ID" value="EA462_04225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01492">
        <property type="entry name" value="RNase_J_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030879">
        <property type="entry name" value="RNase_J_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="5">
        <location>
            <begin position="15"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="387"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="450" mass="50062" checksum="F264823C77C6DBC7" modified="2019-02-13" version="1">MEIEIATIGGYEEVGRQMTAVRAGEDVVIFDMGLNLSQVLIHDNVETERMHSLDLIDMGAIPDDRVMSDLEGDVKAIVPTHGHLDHIGAISKLAHRYNAPVVATPFTIELVKQQIEGEQKFGVENDLIKMDPGETMSIGDSGNVDLEFVNVTHSIIDAINPVLHTPEGAIVYGLDKRMDHTPVIGDPIDMKRFREIGREGEGVLCYIEDCTNANKKGRTPSESVAREHLRDVLYSMEDYDGGIVATTFSSHIARVSSLVEFANDIGRQPVLLGRSMEKYSGTAERLDFVDFPTDLGMFGHRKSVDRTFKRIMNEGKENFLPVVTGHQGEPRAMLTRMARGETPYELDNGDKVVFSARVIPEPTNEGQRYQAEKLLGMQGARIYDEIHVSGHLNQEGHYEMLDALQPQHIIPAHQDLKGFSGYVSLCESEGYQLGRDVHVTRNGNLIQLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPA8</accession>
    <name>A0A3N6LPA8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose-1-phosphate thymidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91268">
        <property type="protein sequence ID" value="RQG91268"/>
        <property type="gene ID" value="EA462_04570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023915">
        <property type="entry name" value="Bifunctiontional_GlmU_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03992">
        <property type="entry name" value="Arch_glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="395" mass="41616" checksum="071D370560175E50" modified="2019-02-13" version="1">MKAIVLAAGEGTRIRPLSASVPKPMLPVADRPLVAHTVDAAIDAGADEIVLVVGYEHETVQAHFGSSHRGVPVSYARQTEQAGTAHAVNTARRHIDGEFAVLNGDNLYEPAAIERLFEARPAVCAVEVASPRNYGVLSTADGTVTDIVEKPADPPTNLANAGAYAFPADAKEWLEVPASERGEHEITDVLSRVIDEFSVTPITTKRWMDVGRPWELLEANEWKLQTLEPRIDGEVSDTAVLEGTVVVEDGATVNSGVTIEGPALIRSGASVGPNAYVRGATLIDEGASVGHAVEVKNSVLSAGATVGHLSYVGDSVLGRDVNFGAGTTVANLRHDDDDVRFTVKGERVSTGRRKFGVVAGDGVKTGINTSLTPGLKLETGATTVPGEVVDRDREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPG9</accession>
    <name>A0A3N6LPG9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl18</name>
        <name evidence="6" type="ORF">EA462_05120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91358">
        <property type="protein sequence ID" value="RQG91358"/>
        <property type="gene ID" value="EA462_05120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_L18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_L5_euk/L18_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="PTHR23410"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="182" mass="20099" checksum="CFE1F56239804A96" modified="2019-02-13" version="1">MATGPRYKVPMRRRREVRTDYHQRLRLLKSGKPRLVARKSNKHTTAQLITPGPQGDETLASAYSGDLEEYGWEAPTSNISAAYLTGLLAGKRAVDAGLEEAVLDIGLNTATPGNKVFALQEGAIDAGLEIPHNDSVLADWSRTRGEHIAEYAEQLDEPLYSGEFDAVELPEHFDEVREAILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPH1</accession>
    <name>A0A3N6LPH1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91363">
        <property type="protein sequence ID" value="RQG91363"/>
        <property type="gene ID" value="EA462_05145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="63" mass="7289" checksum="6B39F1F196C4F0FE" modified="2019-02-13" version="1">MTVEIPIHSNSSGQYRACSRQFANERAVTYNDCDSQTTDERYRQARPYVVSRNQRTITATSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPM5</accession>
    <name>A0A3N6LPM5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="9">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rtcB</name>
        <name evidence="11" type="ORF">EA462_05635</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 9">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the RtcB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91448">
        <property type="protein sequence ID" value="RQG91448"/>
        <property type="gene ID" value="EA462_05635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="GMP-histidine intermediate" evidence="6">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="209"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="335"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="384"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="410"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG91448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="488" mass="53364" checksum="CC115602F7F59472" modified="2019-02-13" version="1">MSNGTFDAGDVTLEQVREHVWELPATGDMRVPARVFASRALLEEISEDKTLEQLRNTTHLPGITNYAICMPDGHQGYGFPVGGVGALDAETGCISPGAVGYDINCGVRMMKTNLTYDEVAGTEAELVDSLFANVPSGLGGGGIVESDVETVNEILARGVDWALEHGYAVEEDLLHCEDEGTREEADPDKVTQKAKDRGKNQIGSLGSGNHFLEVQRVTNVFDAHVGEAFGLEEDQIVILIHCGSRGLGHQTCTDYLRKIERQHQGLLNQLPDKELAAAPAGSQLETDYYGAMNAAINFAWVNRQLIMHRTRQVFERVFDRSWQNMEMELLYDVAHNIAKKETHDVDGDQRELYVHRKGATRAFPAGHPDVPTAYRDVGQPVIIPGSMGAGSYVLRGGENSMDLTFGSTAHGAGRLMSRTQAKNEYWGGDVRDELEDQRDIYVKAQSGATVAEEAPGVYKDVDEVVRVSDELGIGDKVARTFPVCNIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPP5</accession>
    <name>A0A3N6LPP5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88864">
        <property type="protein sequence ID" value="RQG88864"/>
        <property type="gene ID" value="EA462_10720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="6891" checksum="1CEB63787819F2A5" modified="2019-02-13" version="1">MEVPEEWVKKTRQILIRLISSAYSRLIQKFRKSPEKCSVWDLNHLKTVSLAPLASVRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ33</accession>
    <name>A0A3N6LQ33_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91663">
        <property type="protein sequence ID" value="RQG91663"/>
        <property type="gene ID" value="EA462_06870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="177"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="353" mass="39773" checksum="60B115FAEEEEF717" modified="2019-02-13" version="1">MRVAFVSFETIYHRDTETNQRIHSLLELLRDRGHDVHHFCAAFWDGEIDVFERDEITYHGVCHSLEASSSFLLRLPVAIARTSPDVVHVGARPPGQAVAASWGATIARAPTLLEWYGDGGVSNTWWSRRAANSVDRIITPSDLVTTWVRELGVDPGKIDVVANPIDLERIRAVDPAENVDVIYARRLDEDANLESLFLGLAELRGRDWQATVIGDGPERETYERLATDLRIDDRVTFAGDAPLDERIAAYRGAHVFAQTAEHCVFPTEMLWALASGCIGLVEYHAESSAHELVEGWDRGFRTTSEEELADAILEASDLEHREYDERFEEYDIDDVCDRYLTTYRALQKSSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQH5</accession>
    <name>A0A3N6LQH5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89214">
        <property type="protein sequence ID" value="RQG89214"/>
        <property type="gene ID" value="EA462_12675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="63" mass="6936" checksum="175A0AC46426724C" modified="2019-02-13" version="1">MNVADSERIGVDRIALSDAIFVRDERQWRSDDGTDPISGRLVVIAQLHADALRAEARRSTGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS00</accession>
    <name>A0A3N6LS00_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91257">
        <property type="protein sequence ID" value="RQG91257"/>
        <property type="gene ID" value="EA462_04505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="314" mass="32617" checksum="E5353B0541A744D8" modified="2019-02-13" version="1">MAQNPRTSDAEKSRTTDRNSGLSRRNYVRSLAVAATAVTTLGATGTTAATDDYEVIEAENQTITVDSGETWENKLIDMTTGQDIVITAHGSDWTIRNIGFSGENTSGTGSATFGVSDSGGSSTVENVYLGDGSDGRNGSSSGHGQTAFWVDPDHAGHIDFQNVNIQGFADNAIYASAPGNTGGGTIHIDRSFAANCYVSHFRLATEGSKVTNSCVLVDDDGYQGRGIWAWAPGTVEVENCQLEMNGQNTAIDAGANGQATTVVVRETDYDESAGIGEHDGSAVRLEDGVGTDPDAHVPDGVPTSAEEAAAGSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS70</accession>
    <name>A0A3N6LS70_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92728">
        <property type="protein sequence ID" value="RQG92728"/>
        <property type="gene ID" value="EA462_00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="86" mass="9708" checksum="95903DE291575562" modified="2019-02-13" version="1">MSATSNTVQRTASDETRSRDDVAAYIEHLAEVFATVDCTTDVVERTSMHRGETIFEQRENPTVYGGRESRRWTTQSTVGGRLDIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS77</accession>
    <name>A0A3N6LS77_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome c oxidase subunit II</fullName>
            <ecNumber evidence="14">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">coxB</name>
        <name evidence="14" type="ORF">EA462_05165</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.9.3.1" evidence="14"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91367">
        <property type="protein sequence ID" value="RQG91367"/>
        <property type="gene ID" value="EA462_05165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="13">
        <location>
            <begin position="102"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="293"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RQG91367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="335" mass="37006" checksum="E67A5DDA9D8F5F29" modified="2019-02-13" version="1">MQVQTRVDVFEDIFLVFLALGTLVGVVVVAYTLYNAYKYRDSGEPSDDDDLPTLGELPTGGKGGKKLFVSFGLSAIIVISLVVWTYGMLLYVEDGPDDNPTEDAIEVDVEAWAFDWGFEYENGVETTSFDEGMVIPADTPIWIEVTSTDVWHTFGISDLRVKADAIPGETEQTWFMADEPGDYLLECFELCGAGHSGMTSDVTVMAEDDFDQWLDDQLTLTIALEDDQEEPEPVTDGFELLIEHQENDEFEQDLSAALGPDDFEDGTVEITDFDQGGSYDVVITPTDGEFEEIEDTIDFTGPTDETYTLEDPDADDEDNDEDSDTTDDGSGGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSG9</accession>
    <name>A0A3N6LSG9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCS2 family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_01275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92883">
        <property type="protein sequence ID" value="RQG92883"/>
        <property type="gene ID" value="EA462_01275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="485" mass="51420" checksum="F8CA358249AEAD84" modified="2019-02-13" version="1">MGATDTIAEFFGFDEHETDYRTETLAGVTTFLAMAYIIVVNPAILSEAIVIEGYDQGEVFQMLAIVTILASIVGTAVMAFHANRPFGLAPGMGLNAFFAFTVVIVLGVPWELALAAVFVEGIIFIALTAVGARKYIIELFPEPVKFSVGAGIGIFLLFLGLQEMELVVPYVDADGFPSGTLIEMGNALQSPIATLSVIGLAFTFFLYARGINGSIVIGILTTAAAGWLLTLAGLVQPGVLTPDGAYDDVTNEGIVSLLMSVQYDITPLFWGFVEGLGMIADEPLVFALVVFTFFFVDFFDTAGTLIGVSQFGGFLDEDGDLPDIDRPLMADAVGTTVGSMIGTSTVTTYIESSTGIEEGGRTGFTALVVAAFFFLALFTVPLVQTIPHYATYLALVVVGIIMLQGVADIDWDDPVWLISSGLTITIMPLTASIANGIAAGIISYPLIKTAIGDGRDVSLGQWTLAITFVVYFIVYFAAEAGIIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSS1</accession>
    <name>A0A3N6LSS1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate uptake regulator PhoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93023">
        <property type="protein sequence ID" value="RQG93023"/>
        <property type="gene ID" value="EA462_02080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="331" mass="36558" checksum="C2FA06752E830E4A" modified="2019-02-13" version="1">METRKVQMTGGSTYTVSLPKDWATDNDVDSGSTVELYADGETLLVTPRRETDHRTGTLEIELLEGEQLIQAVLTMYVGGFDIIALEANRITTDQRRAIRTAVQGLIGVEVVEERADRVVVQDLLDSAELSIVDAVRRMRLIATSMLEDAVIALVENDDAIARDVIERDDDVDRLWLVVSRTFRATLRSPRASEELGVSREDCFDYHSSARQLERIADHAAKIGHLAVKLEDIPDHVGEALLALQADSAEIIEKSMDALFTEESSEAADLGHDALESVLEIDEHTRRIDDLLRELDPVQAQSLGLVLDSLSRSADYGGNTAETALQKARPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSS6</accession>
    <name>A0A3N6LSS6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91607">
        <property type="protein sequence ID" value="RQG91607"/>
        <property type="gene ID" value="EA462_06555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031604">
        <property type="entry name" value="Ferredoxin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16947">
        <property type="entry name" value="Ferredoxin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="474" mass="52304" checksum="7C37856E8BDF8D34" modified="2019-02-13" version="1">MSSNDDDRTGDDRKNGDDGRGEEPFHPLGTEAEDRYEAMLEEGEYDAELGMEMAKDAMALTKGELSESEFYDRHHEAILEEFGEDDRPMAERVESAREEGRLEGALSRLGADDESRRAVMKKMGAGAGALGLGAFTATDDGTEADPSVAAQDDDADDTADGDDVQWGMALDLESCDGCLSCVVACNAEHNWNEGANWMYILAYDDGTVESPEPEQADTARDFNYLIRPCQHCTDAPCEKVCPTTARHTREDGGLVLTDYDVCIGCRYCQVACPYGVNYFQWDDPEVPDEELNEDMIYDDRDRWVSSRGPRGVMEKCIFDPARQDGQMGEDMVGTTACEDACPPGAIQFGDMNDPDSDPRQYLENVPLARAREQAPDDDDELQEAIAILDGDEEPDEMDEEDAMELLEAEFGDDGSRFKLLEEFNTNPNVTYIGNEPGANAEQVEGPVAYADVGQVDNRKTVLDEKTVGFNELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSW7</accession>
    <name>A0A3N6LSW7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91667">
        <property type="protein sequence ID" value="RQG91667"/>
        <property type="gene ID" value="EA462_06895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="7044" checksum="53D1769988CDB5E8" modified="2019-02-13" version="1">MTPDVDSRPSDAPNPSIRLEHAVVENDDDPDECAVFPTDATEAELRSAWVTARGDDFVDLESVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSX6</accession>
    <name>A0A3N6LSX6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_02525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93098">
        <property type="protein sequence ID" value="RQG93098"/>
        <property type="gene ID" value="EA462_02525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="348"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="471" mass="49402" checksum="E7A09B4DFBCBEBA0" modified="2019-02-13" version="1">MTETFVVVGGDAAGMSAASKAKRDDPDLEVVVFERGQWVSYGACGLPYYVKGEIQSLESLVSVTPEEFREERDIDLRTGHDVVDIDPDDGTVTADADSGSTVQSYDHLLIATGASAVVPPIDGTDREGVYTLGSMSDGKELREYVARARDGESLQQPDRGPACRYLEECNGPVAVVGGGYIGIEMAEALAANEFEVTLFQRSDRVLKGFSGPTSEAVADHLREQGVDLRLEAEVREVTGGPSVDAVVTEEDRVPVEMALLGTGVRPRTALAADAGIELGETGAIETDAFRETNVSDVYAAGDCAEATHVVTGDPAYVPLALTANRHGRAVGQTVTGTPTEGGDIAGTAAVKAFDIEAARTGVLDHDTARDAGFDPLTETVTAKSRAGYYPEGGTVTITLSADRESGRVLGASLVSEYGEGAVHRSHAIVAALQEGATVSDLENYDLAYAPPFNSTWDPVLVAAKVLAGSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUB2</accession>
    <name>A0A3N6LUB2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_03875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91144">
        <property type="protein sequence ID" value="RQG91144"/>
        <property type="gene ID" value="EA462_03875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="337" mass="36357" checksum="52B3029260FF0A48" modified="2019-02-13" version="1">MNRRKGFLLVLVAIFAYLSWQLVVPFLQYVLAALLLAFILYPAQRRLETVISPTISALLLVVVAVVGFLVPFVLVAIVVVDDAAEIAAEIDPEDLEVAAIEDRLEEETGMSVDILESLAGSAEQIGAVLLEQTTTWFSVLTHTLIGIGLALFLLYYLLKEGDSLLAWLRDRTPLPEDVQDDFYGELDQVMWAVLAGHVLIAIIEGAIAGLGLFATGIPNPAFWTVVMIVLSLVPLIGAFLVWGPAVLYLFATGEPMLAIALAVYSAIVVGIADDYLRPIVVDRYADLSPAIIILGVLGGIYAFGIMGLFFGPVVIGALVVTIDVVDEHYDRLSGSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUC3</accession>
    <name>A0A3N6LUC3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="12" type="ORF">EA462_03985</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91164">
        <property type="protein sequence ID" value="RQG91164"/>
        <property type="gene ID" value="EA462_03985"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
    </feature>
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            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
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            <begin position="320"/>
            <end position="326"/>
        </location>
    </feature>
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        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="40"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <begin position="39"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <ligand>
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        <ligand>
            <name>IMP</name>
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        <ligand>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="453" mass="48794" checksum="B975496CD8119AC2" modified="2019-02-13" version="1">MTVTIVGSQLGDEGKGGVVDLYGDAADVVARYQGGDNAGHTVVHGDEEYKLSLVPSGAVQGKIGVLGNGCVVNPETLFDEIDTLRERGLDPDVRVAERAHVILPYHRALDGIEEDEKEDLAAGTTGRGIGPTYEDKAGRRGVRIGDLLDPEILRERLEYVVPQKKSLAEDVFGTETGDAFDIDAIYEAYREYGERLEEEEMAVDCGTFLQERIDAGDNVMLEGAQGTSLDIDHGVYPYVTSSNPTAGGATVGTGLGPTVVGQGEVIGIVKAYLSRVGTGPLPTELGGVEGQTPEYDSSATEESDEELATYIRDEGGEYGTVTGRPRRVGWLDMPMLRHAARANGFTGLAINHIDVLAGLEEIQVGHAYEYDGQERLTMPATTEKWGRCEAMFRSFEGWSDVDWETVAAEGYDAIPENARTYLEYISDELGAPVYAVGVGPGRGETVIVENPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV96</accession>
    <name>A0A3N6LV96_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">EA462_06485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="62"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="62" mass="7000" checksum="6FD089DF40C58F97" modified="2019-02-13" version="1">MRRRYVPGGKTDSDRRRSALTVGRRRSRTTAVTLHSKTDSIRTTRRKDVPLGTPEGEPSATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYA5</accession>
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    <protein>
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            <fullName evidence="4">NADH-quinone oxidoreductase subunit I</fullName>
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        <name evidence="4" type="ORF">EA462_15855</name>
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        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
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        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fer4_7"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
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            <begin position="134"/>
            <end position="153"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="153" mass="17654" checksum="3A292D8060D11498" modified="2019-02-13" version="1">MIGLLKSMATTMKHALDGSTFTVEYPETAPDISPRFRGVHKFSQERCIWCRQCENVCPNDTIQIVMDDKRNGEQYNLHIGQCIYCRLCEEVCPVDAILLTQNFEFTADTKHDLVYNKEQLKSVPWYKDIDPLESREPDRGAWIGDGEGEVDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYT9</accession>
    <name>A0A3N6LYT9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
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                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86912">
        <property type="protein sequence ID" value="RQG86912"/>
        <property type="gene ID" value="EA462_14730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="89" mass="9095" checksum="C65A75A5E64DD8C8" modified="2019-02-13" version="1">MNELQSVLARAQNRFLSPLETVLTVGCGVYVLFGGGPLRTLLLEVSSFRSAVGSSGSAYESEQSLPCGPGGRCSPGGTVAGVVRPNPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ98</accession>
    <name>A0A3N6LZ98_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low molecular weight phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93234">
        <property type="protein sequence ID" value="RQG93234"/>
        <property type="gene ID" value="EA462_03300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="2">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="142" mass="15822" checksum="7BA528987098D7C1" modified="2019-02-13" version="1">MTKIAFVCVGNAGRSQMATAFAERERSQRGREDSVNVVTGGTDPHAHVHENVITALDEVGIDISGRNPREITVEDVADAEYVVTMGCSIDDFVPDDWNGTTEAWNLEHPGSDDLDAVRSQRDEIQQRVEDFFDRIELSDTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZH0</accession>
    <name>A0A3N6LZH0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93324">
        <property type="protein sequence ID" value="RQG93324"/>
        <property type="gene ID" value="EA462_03115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="206" mass="23196" checksum="47F0F18E28CF5FAB" modified="2019-02-13" version="1">MGLLDGLRAALGLRAEADAKRDADPDDLFGMSTAYVTMEAELGYESLDVGALCFSGVESSRFRDAVDEVEAILEAGKEETGTEFSVSADDHGYHWVILEDDNPEDLITSIHFAADTFVEHGYGSRLLAAVFAYDERASTDVRGVAYWIYSFRRGSFYPFAPRTDRERDSSVEFKLEAALDGELEIERDKEYWYPLWPSQHGTHPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0C9</accession>
    <name>A0A3N6M0C9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89070">
        <property type="protein sequence ID" value="RQG89070"/>
        <property type="gene ID" value="EA462_11875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043835">
        <property type="entry name" value="DUF5811"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19128">
        <property type="entry name" value="DUF5811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="130" mass="13647" checksum="F250AAB9E148D9C1" modified="2019-02-13" version="1">MNGNTPYAGLPGETQAGHRAAADIPDLSGTQKRLLHRDVSRIAARTREFLPNEYVVDADVSSGISGPQVTVAVRPPVGHPVSAGFTPDLEDASEEIITSDERNEVARGLAASAAFQVKQAVSENVTPTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M172</accession>
    <name>A0A3N6M172_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-guanine(15) transglycosylase</fullName>
            <ecNumber evidence="1">2.4.2.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-deazaguanine tRNA-ribosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Archaeal tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">tgtA</name>
        <name evidence="3" type="ORF">EA462_10480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:43164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10371"/>
            <dbReference type="Rhea" id="RHEA-COMP:10372"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82850"/>
            <dbReference type="EC" id="2.4.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; archaeosine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeosine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.48" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88821">
        <property type="protein sequence ID" value="RQG88821"/>
        <property type="gene ID" value="EA462_10480"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00393"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01634">
        <property type="entry name" value="TgtA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004804">
        <property type="entry name" value="TgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00432">
        <property type="entry name" value="arcsn_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="2">
        <location>
            <begin position="13"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="491" mass="54559" checksum="49872072A4F7F722" modified="2019-02-13" version="1">MRECFEIRDTDAGGRIGQLSVPRADITVETPALLPVINPNIDTISPRRLAEEFGAEILITNSYIIYGTDDVRERALEDGLHEMFEFPGAIVTDSGSFQLAEYGEIDVTTEEILEFQHAIGSDIGTPVDIPTPPDVSRERAEDELETTQERLELAETVETGEMLVNAPVQGSTYPDLREAAGRHADATALDVFPVGAVVPLMNEYRYDDVVDVVAGAKRGLGADAPVHLFGAGHPMMFALGVAMGCDLFDSAAYALYARDDRYLTVRGTRHLEDLDYLPCSCPICTDFSPDELRMLEDDRREEELAAHNLHVTFAEIRRIKQAIRAGNLLELVEGRARSHPTMLDGYRALLDHAGQLERTDPVSKGTFFYTSHESARRPEVIRHHRRLERLSVPDSLFLTEGEPASRETFDESWRVEPPFGPFPRALSRSYPLTAEVPGRTDRSALRAAADGVRRLVETNPETAVTLGHRGWPESVLDRVPDRVALVDLTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1P7</accession>
    <name>A0A3N6M1P7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydrofolate reductase</fullName>
            <ecNumber evidence="1">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_11485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89001">
        <property type="protein sequence ID" value="RQG89001"/>
        <property type="gene ID" value="EA462_11485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="5">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="184" mass="20728" checksum="CE4B6E92302742F3" modified="2019-02-13" version="1">MTESDDEPSTSDGLETDRELVAIVAVAENGVIGRDGEMPWHVPADLEHFKSKTMDHPVIMGRVTYEGILEQLEEPLPGRTSIVLTSRDFATPERTVTVSGFEEALRAAERVARDRHDGTDRIFVGGGATVYDGLFPAVDRLVVTEIHDEPDGDTHFPDWDRSRWREVDRDERDGFGFVEYVRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1Y3</accession>
    <name>A0A3N6M1Y3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89101">
        <property type="protein sequence ID" value="RQG89101"/>
        <property type="gene ID" value="EA462_12065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="11"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="261" mass="27533" checksum="44D9A7E05500AF08" modified="2019-02-13" version="1">MTEPIRTLLTGATGTLGGQLRPRLRDAGHAVRAASRSPPSEPDADAEWVEMDLADGTGIEAALENVDVVVHAASAPRGDTEAVDVEGTRRLLDAAAQAGISNVCYVSIVGVDSVPLTYYQHKLEAERAAEASEVPSTIVRLTQFHSFVFDVLEAISRVPVWPLPVDVPLQPIEPGEAAAAVVDRATADPQGRVPPVGGPEVRTVGELARAYRTATGSRRPIVPVPIPGAVAAGFRSGEATCPDRTVGTTTWKRWLAHQSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M214</accession>
    <name>A0A3N6M214_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89141">
        <property type="protein sequence ID" value="RQG89141"/>
        <property type="gene ID" value="EA462_12275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="390" mass="40977" checksum="7532FE369A1078CF" modified="2019-02-13" version="1">MRWRYSETVLLLCTLAFFATMVGRLAISPVVTLITDDFAVSNSVVGIALTGMWMAYFASQFPSGILADRFGERPIVLVAIGGTALASVFLALTPFFTLFVMGTIALGAVAGLHYSVATTLLTRTYDEIGAAIGVHNVGAPAAGLVAPPIAAWIGVRYGWRPAVAAAGVIALPVFVLFAWRIRPVEPRRPSQPMRERFELEAIVELISRPEIVFPICISVVGAFAWQATASFLPAFLVEHRNQSTEFAGVVFAGYFVVQAVTQVGVGAASDRYGRYVSTAGCMALAAAGFVLLVAVPGFLAIAVAILLVGTGLGWGAALLPRFMDVLGDAERGAGFGLVRSVYGFIGALGSVVTGTLADLFGWDVAFTVLAGLLALVCCAIAVNVVLSLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3I5</accession>
    <name>A0A3N6M3I5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_16115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86667">
        <property type="protein sequence ID" value="RQG86667"/>
        <property type="gene ID" value="EA462_16115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="71"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="248" mass="27335" checksum="6649C843D5E7AB0A" modified="2019-02-13" version="1">MATELGDETIEATVRSFSVLDVLIDSAQPVGVTEIASRTNMTKSTVYKHVNTLVALGYAEKVGSQYEPAIRFLDCARRIRWDNDLIRTVREPVDELAEMANEVAGLVIERNGVAIDVYCADQYYSGTFPAYNTRHLHCSAAGKAILAELPDERVESLARTSTALTEHTITDPDELLLELARIRERGFSLDRQEQFPDVNSVAVSVETDSFVASVYVSGQADELSGKRFEENIPGLLLSASRMLASTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3K7</accession>
    <name>A0A3N6M3K7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86697">
        <property type="protein sequence ID" value="RQG86697"/>
        <property type="gene ID" value="EA462_16285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="336" mass="37211" checksum="8EBD631997956252" modified="2019-02-13" version="1">MEHCQVNEDEAVAVVTDVKSNREHVAASFAAAQDIGAEVFEVQIPEYGRNSVGAEVSAGQGGSLRLPRGPVEACKSADMVFDFTLEGFIHVPERGEIRDAGTRILRVGAREPFVLRRLMPWEPEEARAVKEKVQAHRDLLESADEMRVTSEYGTDVTMEVSPETAFDSYGFVDEPGKWDVWGQNMVSNYPTNVNGTVVIAAGDYNVVPFSDYIDSSIECVVEDGFIEEINGDGGDAELMRGHMESYNDRDVFATSHFGWGLNENGTFYNMAIKDRKPDETGVSASEGRVWEGNMLWSTGPNTHQDRYTNCHYDIAQKNCSVYLDGEPVVLEGDLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4Z5</accession>
    <name>A0A3N6M4Z5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">GTP cyclohydrolase III</fullName>
            <ecNumber evidence="1 2">3.5.4.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gch3</name>
        <name evidence="3" type="ORF">EA462_10120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:22468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57258"/>
            <dbReference type="EC" id="3.5.4.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the archaeal-type GTP cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.29" evidence="1 2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90321">
        <property type="protein sequence ID" value="RQG90321"/>
        <property type="gene ID" value="EA462_10120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043740">
        <property type="term" value="F:GTP cyclohydrolase IIa activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00608">
        <property type="entry name" value="GTP_cyclohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007839">
        <property type="entry name" value="GTP_CycHdrlase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42202">
        <property type="entry name" value="PTHR42202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05165">
        <property type="entry name" value="GCH_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009265">
        <property type="entry name" value="GTP_cyclohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="253" mass="28073" checksum="63EC6A49DB413530" modified="2019-02-13" version="1">MTNTQVTLVQIDNYGPWTVTPEPRREADLQTLQSRLYADISQFVGNRDGYVFFTRFDNMIAVTNGLSMSDHRLLQETMGNRYPVTLSLGVATGTSPVQALSDATSLVQDAGSAQDKSRRECLEGRVIDDAHRTDDDVQIAHFDVVDATGQYTDELNAFDSFIHIEQGYAELMRHMRSDHESLSFFVGGDNIIVVCPDLERSEYETAIQHVEAAVDVELQVGVGRGISAHDAGFAAKHALETCRADGTRVELEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M549</accession>
    <name>A0A3N6M549_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_13190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87819">
        <property type="protein sequence ID" value="RQG87819"/>
        <property type="gene ID" value="EA462_13190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="20"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="369" mass="39513" checksum="F9D48DC0EC759CF1" modified="2019-02-13" version="1">MWHRRFYRGMSTHDQAALPTDMDALVVEEAGEWSIETVETPNIDQTDNVLCKVDTVSICGTDPKIFHGDVDGWPPSFPFTPGHEWAGTVVETGEDVSRLSPGDRVFAETHHGCGYCENCRNGKYNLCENYGDFDSGHRQIGHTSSGAYAEYIAAPADTLYHLPESISFTEGALLDVNAIALYLAERGNIGPAANVAVIGTGTVGLLAIQNAKALGAGNVIAIGSEDRNTVGAELGADHTIPYTDDDVVEQVMELTGDVGVDVTLEAAGTSSSFSQAVAITRKGGTVSLDGIPKVNHQEIPMADLVTEEIEFRGCRAHANLAEASARLVENGTVDVSALVTHEFSFNEFETAYETFVDRHDGAIKVALHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5I1</accession>
    <name>A0A3N6M5I1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_14115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87989">
        <property type="protein sequence ID" value="RQG87989"/>
        <property type="gene ID" value="EA462_14115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="70"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="30407" checksum="555EF607A9150CB2" modified="2019-02-13" version="1">MEHGSRKNELETTHRSLELVETIKRLDGATLAELTNESGLAKSTVFKHLKTLAKSGYLEKEGERYHIGMKFYNLGQYARTRKRAYNLATKTARRLTEETNEEVDVGIENDDRELIIYESYHPEHRYEAGEVQSRNPDYHTGTYYYLHWTAAGKALLAAMPDSHVERIVDRWGLPSRTEQTITEESALYDELETIRDRGYALSDEEFVDGLRAVGRSVCDPTGEVVCAISLFAPAYRMTDDRFTEEIPALLEEATTELEREINPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5L3</accession>
    <name>A0A3N6M5L3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_04880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91320">
        <property type="protein sequence ID" value="RQG91320"/>
        <property type="gene ID" value="EA462_04880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="PTHR16228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MgtE" evidence="6">
        <location>
            <begin position="57"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="194" mass="20534" checksum="022EFE35C0DA92D8" modified="2019-02-13" version="1">MVVPSATASLGSWNWKRIVRNMFPLLVILSIIVLWAGITLESAEEWLDRYVILAVMVPTMVDMGGNLGAILSSRLSTRFHLGTTELDPTDRVLWANVGAVLALAATIFTALGIGAYLLGFAIGSTLPLSTLLLISLTSGMSVAVIAVVFSFAATYGSYRLGIDPDDTTIPIVTNVVDVFGMVIFIGVSIAVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5Q9</accession>
    <name>A0A3N6M5Q9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88099">
        <property type="protein sequence ID" value="RQG88099"/>
        <property type="gene ID" value="EA462_13590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="299" mass="33121" checksum="E3579CC71393E175" modified="2019-02-13" version="1">MDDAIARSIEDGQSVYLGGFTHLIPFAAGHEIIRQGYQDLTLIRATPDLIYDQMIAAGCASAVTFSYAGNPGVGSLRAFRRAIEDGVPNELSIDEYSHFGLVSRLEAGAKDLPFVPLRSYVGSGYPDHNDSIRMVANPYDDDVDEIAVVPPLRPDVAVVRAQRADDEGNAHLWGITGEMVEAAFAADTVVLSVEELVDRDVIRSDPNRTAIPGTIVDHVVEEPYGSHPSYAQGYYDRDNVAYLEWDEISETHESTTEWLSEWVHGVDGRREYVAKLETERLLDLQPRTNFSTPIDMGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6E7</accession>
    <name>A0A3N6M6E7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_06745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91640">
        <property type="protein sequence ID" value="RQG91640"/>
        <property type="gene ID" value="EA462_06745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="3">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="716" mass="80218" checksum="8ACCC6D7BE107A82" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6K7</accession>
    <name>A0A3N6M6K7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91720">
        <property type="protein sequence ID" value="RQG91720"/>
        <property type="gene ID" value="EA462_05875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="227" mass="24672" checksum="40179B8ACE0E5E21" modified="2019-02-13" version="1">MNSVQSVLDRYAGGTPYERLTRQFLEFDRWSGDDPLLLVAETAVATTGQRSAGGRNADVSEFRDAFVATGRVDSFETLAGLESEDAGLSEVFAAARTRRVLLEVASVLSARPEADDLAALRGWAGEADQYRYDEDPIGSISGIGPSSFQYLRQLAGMDVAAPDATVSRFVDTVDTELESATLETTSPLLTIASCEWLAIVSAYSPIEIDRIAWWTFADEDERQVALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M753</accession>
    <name>A0A3N6M753_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase II large subunit</fullName>
            <shortName evidence="13">Pol II</shortName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Exodeoxyribonuclease large subunit</fullName>
            <ecNumber evidence="13">3.1.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">polC</name>
        <name evidence="17" type="ORF">EA462_12480</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 13">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the archaeal DNA polymerase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="EC" id="3.1.11.1" evidence="13"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89176">
        <property type="protein sequence ID" value="RQG89176"/>
        <property type="gene ID" value="EA462_12480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008852">
        <property type="term" value="F:exodeoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000738">
        <property type="term" value="P:DNA catabolic process, exonucleolytic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00324">
        <property type="entry name" value="DNApol_II_L_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004475">
        <property type="entry name" value="PolC_DP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016033">
        <property type="entry name" value="PolC_DP2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42210">
        <property type="entry name" value="PTHR42210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03833">
        <property type="entry name" value="PolC_DP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00354">
        <property type="entry name" value="polC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="16">
        <location>
            <begin position="1406"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="281"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="283"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="659"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RQG89176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1921" mass="214115" checksum="EDE9BADFFF729B55" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7B4</accession>
    <name>A0A3N6M7B4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89246">
        <property type="protein sequence ID" value="RQG89246"/>
        <property type="gene ID" value="EA462_12850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="238" mass="25295" checksum="FA66FBB57763DD03" modified="2019-02-13" version="1">MSGEQATATEGGQPSRIQVPADPLAGHPATAYFWGHVAGSGDVAADRLAVVTTDEASARVLAAVAGGDVERDGTRREYAHDRSITRSEDEYTLSITPGDSAGLLGRNSVLGLPVDGRGNYRFDAFAGHDRELLRGLFEGCGTICFKSSSGTVGVSFVHDDPALLEFGRALIVECPVAAPTGDLSETASGGYWFGVDDSRAPAFGRWLYEDCEETGLFAPSRRRKLERSLSQADAYDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7E2</accession>
    <name>A0A3N6M7E2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91261">
        <property type="protein sequence ID" value="RQG91261"/>
        <property type="gene ID" value="EA462_04525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="94" mass="10722" checksum="E34A840BFBC85625" modified="2019-02-13" version="1">MNVRGGGVRRGYARAVDSVAFVRAQHYMPIDDVPLRMFRAILPEGQIVCERYDHTEKGLELYDTDDEFIAFVPYANLHALVNEDVYGGNERSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7T3</accession>
    <name>A0A3N6M7T3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">trpD</name>
        <name evidence="6" type="ORF">EA462_05360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91401">
        <property type="protein sequence ID" value="RQG91401"/>
        <property type="gene ID" value="EA462_05360"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="71"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="106"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="338" mass="34431" checksum="D626F60F29B1A758" modified="2019-02-13" version="1">MKEYIERVADGTDLTQADARAASTAVFEDATEAQIGALLAALRAKGEMEAEIAGFAEGMRDVARTISPDREPLVDTCGTGGDDYDTINVSTTSAIVAAGAGVPIAKHGNYSVSSSSGSADVLEEVGVNVEAEPPAVETAIDRDGIGFMLAPVFHPAMKAVIGPRKELGMRTIFNVLGPLTNPAGANAQVIGVYDADLVPVLADALARMDTDRALVVHGSGTDEIAVHGETTVAEVQGDRVEAYTVEPTDIGLDEHAISAIAGGSPEANAADLRGIVEGDVTGAKRDVILANAGAAIYLAGEADSLEEGAAVAREAIDSGGAATKLEQLRSAVPGLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9Y4</accession>
    <name>A0A3N6M9Y4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterio-opsin activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_09010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90376">
        <property type="protein sequence ID" value="RQG90376"/>
        <property type="gene ID" value="EA462_09010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAT" evidence="4">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="222" mass="24479" checksum="90179E57162D4911" modified="2019-02-13" version="1">MTSIADIEIPADGTGLGELFDDVPGLTCEMERVIASSGHGLWLAGSSRSKIEDALTDAAAIDTYSCITDDEERYLYDIEFDDGTVDPFEVVLEQNGTVLSASASNGSWLLSVRVIDRENVSTLYDRLVEYDVSPTIVRLFDLAEESRTQCGLTARQYETLVAAIDHGYFEIPREVSMQELSDELDISHQALSERLRRAYRALVTSELNVTEEEATAPPLASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBP2</accession>
    <name>A0A3N6MBP2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pyrF</name>
        <name evidence="9" type="ORF">EA462_03535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91086">
        <property type="protein sequence ID" value="RQG91086"/>
        <property type="gene ID" value="EA462_03535"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="266" mass="29261" checksum="72421AD09AB33BD9" modified="2019-02-13" version="1">MNFFDRLHDRIRTVDSVVSVGLDADRSRIPDHLESHDLPRWAFNRRIIDATHEHAAAFKPNAAFYEDPDGWQALEETVAYAHGKDVPVLLDAKRADIGNTTRQYARILETVDAITVNPYMGRDSLQPFLANEEAGVFILCRTSNPGGSDLQDLELETGEPIYERVAALADLWNERDNVGLVVGATNPDELAEIREQVPDLPFLVPGVGAQGGDAEAAIEHGLSNGVGLVNSSRGIIFAGESSGKEFARASGQSAKRLKERLNQYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC05</accession>
    <name>A0A3N6MC05_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="4" type="ORF">EA462_04290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91216">
        <property type="protein sequence ID" value="RQG91216"/>
        <property type="gene ID" value="EA462_04290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="3">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="154" mass="17551" checksum="D7E47CCBF9547C40" modified="2019-02-13" version="1">MSGHERTFVMVKPDAFARGLVGEVVSRLEERGLKLVAIKVENMPRERAEEHYGEHEDKPFYDDLVEFITSGPVVPMVWEGQDATRQVRQMIGETDPLEAEPGTIRGDYALDLGRNVVHAADHEDEGANEREIGLHFDDDELVDYDQHDTGWLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFZ6</accession>
    <name>A0A3N6MFZ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TIGR01210 family radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_01070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92846">
        <property type="protein sequence ID" value="RQG92846"/>
        <property type="gene ID" value="EA462_01070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005909">
        <property type="entry name" value="RaSEA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004954">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01210">
        <property type="entry name" value="TIGR01210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Elp3" evidence="7">
        <location>
            <begin position="55"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="365" mass="40754" checksum="2FD10570BDC36938" modified="2019-02-13" version="1">MSKPTPGVYEQGKGMDAHNQVMREIRSRKEASYDPHEPTRVWLDEDNTPNGVKTSLTIILNTGGCRWARAGGCTMCGYVAESVDGGSVSHEALLDQIDVCLEHEAENATEPAELIKIYTSGSFLDEREVSGRTRRAIADAFSDRERMVVESLPDFVDREKLSEFTRHGLDTDVAIGLETASDRVRHDCVNKYFDFTDFEDACAEAVAADDERESAAAGIKAYLLMKPPFLTESEAVEDMVSSVERCSAVEGCHTVSMNPCNVQRYTMVDDLYFNDGYRPPWLWSVAHVLRETADVDAIVVSDPVGHGSDRGPHNCGECDDLVQKAIKDFGLRQDPSVFEQVSCECERTWTVVMERERSYNQPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGA2</accession>
    <name>A0A3N6MGA2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92966">
        <property type="protein sequence ID" value="RQG92966"/>
        <property type="gene ID" value="EA462_01760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="215" mass="22814" checksum="90C63B48E29540D0" modified="2019-02-13" version="1">MSRSWTDRVDQLLYDGERVERRVECGRATVFVTTHRVLAFEPDEVGSAYRHVDRPNVASATIRTDGATRHLLRAGGGAIVGVSLLGLHLLVSFAALVPSADLEQPDARTDSGGAVVGNAIETVEILFRMIDLAILASGLLAIAVAAGGGLLYARSRARRLVLEVRGDDDIAFAADEIDDVGAVALELEDAIRPDSSLEEITRDDADGSGSKPPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MR72</accession>
    <name>A0A3N6MR72_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86743">
        <property type="protein sequence ID" value="RQG86743"/>
        <property type="gene ID" value="EA462_16545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="74" mass="8160" checksum="AC218078DA82762E" modified="2019-02-13" version="1">MTTGGETPRLLSSETGEFALISTSRFATTTIFIVRSAGVDTRSRRTGDDDRSVRGLYDLVYVSSATATRLQFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRW3</accession>
    <name>A0A3N6MRW3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87023">
        <property type="protein sequence ID" value="RQG87023"/>
        <property type="gene ID" value="EA462_15385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="96" mass="10190" checksum="17F8E3E43C25A956" modified="2019-02-13" version="1">MSSDVDRGDRDLHAELESPSAGQRGVPVDAICVGCGRTRVKRASLAEMDQSPAVDPATLKATDLTSFKHVCHPCGSATWWNPVAVLSGLLESERGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MS54</accession>
    <name>A0A3N6MS54_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87053">
        <property type="protein sequence ID" value="RQG87053"/>
        <property type="gene ID" value="EA462_15560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="4"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="385" mass="40740" checksum="37FA01768221310B" modified="2019-02-13" version="1">MTRARLFGSLCGLVFFLNLARIVFAPLLDVFIAEFGIGEATAGLIVTLVWIGSASLRLPTGWLLTKVPRHHVVIGAGTILAVSSGFTATATTVGHLMVGAFFMGIASGVYFVSANPLLSELYPDRVGHVMGIHGGASQMAAVIAAPLVALTLVVDWRLSIWTIAAGATAVTVYTWIVTRRTEMPEAGRSDRDFVSGALSEWRLIVTALVLVGTTVFVWQGVFNFYELYMQSKGLSSGAAGTMLTIVFVAGVPAFYVGGDLADTLPHVPYLLGIVAAFSLCLFALTLVEGLIALIVLSAVVGFVIHALFPAVDTYLLDTLPDSTRASAYAVFSSVWMLTQALGSSVVGLFIEGGYTYDWVFASAALFLASSVVVLALIERSGRLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSU0</accession>
    <name>A0A3N6MSU0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87825">
        <property type="protein sequence ID" value="RQG87825"/>
        <property type="gene ID" value="EA462_13225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="361" mass="39535" checksum="A233310722323788" modified="2019-02-13" version="1">MSQETVSEQVDEAPLFSWESWDRIKYSEGFVFAATTAFVLLWSWLFSRAPITSELGGYHSLATTMLIWGIFALGFNLLLGQTGLLSFGHAMFWGGGGYAAAIFAIHISGDPILVLVVGTLFTLLLAVVTGVIALRLHAVYFAIITLAMGQLLYYLATSPLRPITGGRNGLTGVQIEQLFGIAYLQEPLPGVFGELWVNYEYLFIALVFVLVVVFVNRVRKSPYGLIFRAIRENERRTSFVGLNVWRYKFAAFLMSAGIAGLAGSLYTIESQFAGLSSLYWFTSGEVVIMSVLGGVGSLFGPVLGAILYLYFEGVVDGVAIIGRYWLLMLAVVFTAIVWAYPDGIWGMIKSGGAKVRAKLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUL5</accession>
    <name>A0A3N6MUL5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_12015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89092">
        <property type="protein sequence ID" value="RQG89092"/>
        <property type="gene ID" value="EA462_12015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="635" mass="71515" checksum="DC3951CA36D87A4F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWB8</accession>
    <name>A0A3N6MWB8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89772">
        <property type="protein sequence ID" value="RQG89772"/>
        <property type="gene ID" value="EA462_07065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="105"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="274" mass="31213" checksum="7B0FDD948F769514" modified="2019-02-13" version="1">MARIANLWVYPVKGLDRMSVEEIRINDAGTFQGDRAYALVDPEERSRIEDRTDSVEKTFNGKEIDDLHSFESAFDPETETLTLRIDETSETSRFDLSTDRDEASDWFSEFVGEAVELRERGPPSFIDRPKLGPSVISTGTLEEVASWFDSMSVEGARRRFRPNIEISGVPPFWEDQFLRENPSGFDVGRTRFEGAEACARCVVPSRDPDTGRETENFSARFSERREQTLPEWVDEDAFEHFFTVMLITSVPERSRGTTVRVGDEVSANQDLETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MX79</accession>
    <name>A0A3N6MX79_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome-activating nucleotidase</fullName>
            <shortName evidence="5">PAN</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Proteasomal ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Proteasome regulatory ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Proteasome regulatory particle</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pan</name>
        <name evidence="9" type="ORF">EA462_08885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90102">
        <property type="protein sequence ID" value="RQG90102"/>
        <property type="gene ID" value="EA462_08885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022623">
        <property type="term" value="C:proteasome-activating nucleotidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00553">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023501">
        <property type="entry name" value="Nucleotidase_PAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="182"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG90102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="405" mass="45290" checksum="4A7729A4693B1011" modified="2019-02-13" version="1">MSDTVDDVDLPYDEDETSQQEKIQALEDQLEILEAQNEEMRDKLLDANAENNKYQQKLERLTHENKKLKQSPLFVATIQEITDEGVIIKQHGNNQEALTEVTAEMREDLEPDARVAVNNSLSIVKSLSSETDVRARVMEVTESPDVSYEDIGGLEDQMQEVRETVEMPLENPGMFDDVGIEPPSGVLLYGPPGTGKTMLAKAVANQTDATFIKMAGSELVHKFIGEGAKLVRDLFKVAREHEPAVIFIDEIDAIAATRTESKTSGDAEVQRTMMQLLAEMDGFEERGEIRIIAATNRFDMLDRAILRPGRFDRLIEVPKPGKEGRELIFEIHTRGMNVSDDVEFTALAEEADVASGADIKAICTEAGMFAIRDDRTEIRMDDFRDAWEKIQADGDETDDVSKTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0Q6</accession>
    <name>A0A3N6N0Q6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91492">
        <property type="protein sequence ID" value="RQG91492"/>
        <property type="gene ID" value="EA462_05890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="88" mass="10104" checksum="4B129C0CD1BDC148" modified="2019-02-13" version="1">MKQLIIYGDPGIRAGAIVEYDDEEVVCFGINRNGEWNGPEEVQLWCTVGDDSEYEDYEKRNYIPHFLEVDHVDAEDVDVVRPKADLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0U3</accession>
    <name>A0A3N6N0U3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91542">
        <property type="protein sequence ID" value="RQG91542"/>
        <property type="gene ID" value="EA462_06170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="121" mass="13773" checksum="2154D28B9B79FA94" modified="2019-02-13" version="1">MDPRSTTRMEAACSLLAESERRYLLYLLAEGRGSSLEDLVTQVAAWELEQPAATVDSEGRQRIYAGLVHNHLPRLADYGIIEYDLRSDEIVLADGFDDIKPLLEQFRQTEEVPEIRQRPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3Y5</accession>
    <name>A0A3N6N3Y5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92872">
        <property type="protein sequence ID" value="RQG92872"/>
        <property type="gene ID" value="EA462_01210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="151" mass="16022" checksum="3A52EAB76CBDDCA8" modified="2019-02-13" version="1">MFDTVVVATDGSESVKRAVDVSLDLARRFDADVHALSVVDAGEVDASPEQLRDELRAALETHADAALATVESRSGGDVTTAVREGRPAAEICEYARGIDADLVATGTRGRHGENRLLLGSVAERIVRTSPVPVLTVRQLEPSQRTESTADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N428</accession>
    <name>A0A3N6N428_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92922">
        <property type="protein sequence ID" value="RQG92922"/>
        <property type="gene ID" value="EA462_01490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="321" mass="33897" checksum="AAAB564E970FB293" modified="2019-02-13" version="1">MNRRRYLAGWAAALAAFAGCLDGDGNGEANVDDRTGERALSRGIGQLNDAAIALQIEDELAEPESVDFDPDTPRTHLSTARDHLETAEAELEDERAGDIDELRRYATVLEAAIDVAGTVTDEALFEEIERIETALADGGDEHDRETTTELLDDRIEALETAGDRLTDAKAAIEAIDEGRYESLETVDLTDVESGVSTLEAVVISQSALASGYDATLEGDDDLDRGRAYADDGSHGDAEAAFLDAKASFETATETFEGGSDDAPDGLEGYFETALCRSNHLTDAAANFANASAAADDGDVVAAGQYRDDAEDALDAAASCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N496</accession>
    <name>A0A3N6N496_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92992">
        <property type="protein sequence ID" value="RQG92992"/>
        <property type="gene ID" value="EA462_01915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013561">
        <property type="entry name" value="FilR1_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08350">
        <property type="entry name" value="DUF1724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1724" evidence="1">
        <location>
            <begin position="198"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="29713" checksum="D4929EC3505E5BCF" modified="2019-02-13" version="1">MDSSLEEIEFLALSANRVDVLRLLSDDRCTRRELAEATGASQATLGRILADFDDRSWVRRDGSEYAATATGRLVATGFTDLQEIIETERTLREIVDYLPTESLSFDLRRLSDATITVPTQTRPNAPLQRLLGLLEDADEVWTASHAFNEQTLTVVRERTLEGDQRFNGVFSRSAIEALTHDSGLRRRLEGLLETEHASVRITDEEIPLAVMIVDDVVTLLLRDDDGILRASVDVSDEVIRSWAENTFEAYWERATPLDVEMVGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4D9</accession>
    <name>A0A3N6N4D9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93042">
        <property type="protein sequence ID" value="RQG93042"/>
        <property type="gene ID" value="EA462_02185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="235" mass="25504" checksum="DFBCDC9F38E75FA4" modified="2019-02-13" version="1">MHAIVPAAGEGTRLRPLTSDRPKGLLEVDNRPILSHCFDRLCEVGVTVIVVVIGYRGAQIVDYYGDCYGEAPIRYVRQPERKGLAHAIAQAADAVEGDVLVCNGDNVFGTSLESVVETRRRSDVDAALLVERASPAVARTTGVVVTDESGTVTELVEKPDEPPSTLVTTGVYALPESIFEHCRAIAPSDRGEYELPDAIARLREHGGVVETVELEGWRVNVNTEADLSEAERKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NV03</accession>
    <name>A0A3N6NV03_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Monovalent cation/H+ antiporter subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_15725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87080">
        <property type="protein sequence ID" value="RQG87080"/>
        <property type="gene ID" value="EA462_15725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="345" mass="38231" checksum="4F389E8CF039F192" modified="2019-02-13" version="1">MTANRVLVPLSDTVTVRQTIGYAVRTGLGSDDPLEVHLVVALPYDTDVPEGDVQIEEARQLLSRARRWLEEDTGGADITVETAVIGDDEYLFGPRDYADTFGEYADDHGIDLLVLDPEYQPGVTSSILQPLERELEAVGLSYDEAAVERPARHERLVGEGTERFDRYFALFWISYGFYLVLGDPTYWFDLVTGAAVAGIVSLSLANVTFSFPLGRLESPLRTIRFGMYVPYLVWEIVKANIAISYVILRPSMPIEPTVTRVNTRVRSGLPLLALANSITLTPGTLTVRANDQRLIVHTLIPSAREDLFDGALERAVRFVFNGRESAAIPTPRERGDTEIIGGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVJ2</accession>
    <name>A0A3N6NVJ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Divalent metal cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_13445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87862">
        <property type="protein sequence ID" value="RQG87862"/>
        <property type="gene ID" value="EA462_13445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="416" mass="43574" checksum="0B87BFCA3A21BB43" modified="2019-02-13" version="1">MAQGDATSSIEDLRWPSLGSAVRRIGPAFVLGAVALGPGSLVLSSMTGALYGYQLLWLLVFSGVFMIVFMEIASRFGIVTDEPIWTIVEHKYGRTAAVVGGIFAVLTSLGYETGNVIAIGLGMEAIVGGSPLIWGTAGAVAAIALITLQDLYDKLEKLIFALIFVMIVGFFGTLAITGFSPGDATSGLVPTFPDQQAVFLGMAMMATYFSLYAAIYQTYLVKEKGYTTDDIGQSIFDSAAGITLMGIMLIAIMIAGAVVLNPAGVIPESAVDMAVQLEPLVGTNASLLFGLGLFAAAFSSIVVNALIGSTMFVDGLGYETGMDSKPVKLVAITLVVVAWLFAFVPSLLGENPIDTLILAQAVSIVGLPYFGAVILILSNDRDVMGGFANTRIRNALALIGYLASLGIAIYYATSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWW5</accession>
    <name>A0A3N6NWW5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosome biogenesis/translation initiation ATPase RLI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_11925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89079">
        <property type="protein sequence ID" value="RQG89079"/>
        <property type="gene ID" value="EA462_11925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="PTHR19248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="76"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="353"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="575"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="116"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="386"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="604" mass="67495" checksum="1FC62361C52C56F5" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYI3</accession>
    <name>A0A3N6NYI3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89899">
        <property type="protein sequence ID" value="RQG89899"/>
        <property type="gene ID" value="EA462_07765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="183" mass="18850" checksum="6F37E34980BCD34F" modified="2019-02-13" version="1">MSTESDTVSAFGISSSWGWSIGGIVGGVIGAAAFGLIMWLVDPEILSGAIPAIYGLEAVGVVGWGIHLAHGAVLGLVFGYVVSRDPVLGVLKTTPETEVLSRTGVTLRVIAAGFVFGLAIWAILPLIVLPVWLETIGTQAAGDFPGIAIESLIGHVLFGTVLGIVFAIGVDLRDRTSGTPLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYL6</accession>
    <name>A0A3N6NYL6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_07980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89939">
        <property type="protein sequence ID" value="RQG89939"/>
        <property type="gene ID" value="EA462_07980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="41"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="45"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="154" mass="17637" checksum="3F6F064E009294E4" modified="2019-02-13" version="1">MSRRSSPFDGLAELFDKLARQLETAARSWETEIDNRSRLDLSMGREATNLDLTDEGEEFIVTVDVPGYDRDDLDIRLTGETLSITGERERTEEHEAGEEMYIRRERELQSFNRHVRLPDPVDVDDVSATVNNGILTIKLPKLEFEGESHSINVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ61</accession>
    <name>A0A3N6NZ61_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_09380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90189">
        <property type="protein sequence ID" value="RQG90189"/>
        <property type="gene ID" value="EA462_09380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="375" mass="41265" checksum="450A7896FE391B3A" modified="2019-02-13" version="1">MTGVAIADAVDAFLERKAVGDPDGPGAGSYASNAESILRRFVTWAEAEHGIVTLFSLEPEHMRAYAVELGDRTERGEYTASTAGTYFAVVRAFLSWCVRGGIIPENPAATETAESALPSGDDRSTDDGWTASQRRRLERHVRVRALDSSADSVGVDDRRSRLREYALVAVLTHSGARGSELFRVPEDDRRTGATWDDVDFYTGTIRVLGTGQRDEEVSLLAPARTPLRRYRIVLDPPTNDWPLFPTRHAPSIARHVRERLRGRGYGDDEIEAMLSDRTAIELARERAIAPPAITTEGARSVLERLCSEADLDVDGVYLTPRDGRTDEADHVRREATGSKPVLRSPGERSIAVPIDRTVRADTADSDEPDGDPERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ87</accession>
    <name>A0A3N6NZ87_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90229">
        <property type="protein sequence ID" value="RQG90229"/>
        <property type="gene ID" value="EA462_09605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045396">
        <property type="entry name" value="DUF6517"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20127">
        <property type="entry name" value="DUF6517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="258" mass="26830" checksum="A95F44D75F9EE0BD" modified="2019-02-13" version="1">MNRRDVIAGIGATGIAALSGCLGVLGLDEHVSSPAGVEPSISDDTGYEQTDVDSVVVERELSLGPLTEEVVAENYLTEYEKSVEMGVLGEQRGAVFTVLSTPKVDVLGREFNPVEEMSAGELVELIESNYDDIGDVSLEDERSVSILGESTPQSRFSAEAAFDGTTVDVDLHVTEAVSAGEDLIVTIGVYPEQLRSGESDNVRALAEAVTSSLEEGEPADDDDTDDDGSSDDGGDGDDGSSDDGGDGDDDGINIGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ94</accession>
    <name>A0A3N6NZ94_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Appr-1-p processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90239">
        <property type="protein sequence ID" value="RQG90239"/>
        <property type="gene ID" value="EA462_09655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="189" mass="19477" checksum="6E9C9D96132F4107" modified="2019-02-13" version="1">MEFEVIQGDIAVQSADALVNAAGTNLRMGSGVAGALRRGAGEEINRAAMENGPVDLGSAAVTDAYDLEADYVVHAAAMPHYGDGKATAASVRDATRNALERADELGCRSIVIPALGCGVAGFDLEAGAEIIGEEIGRYEPNSLEDVRFIAYSDEEYETISTAVRGATGSADTAESVSATESEETTGSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P083</accession>
    <name>A0A3N6P083_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87818">
        <property type="protein sequence ID" value="RQG87818"/>
        <property type="gene ID" value="EA462_13185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="29107" checksum="F397E64B1D63FA2D" modified="2019-02-13" version="1">MTAFDSLEQIDLSLGIVPDSDSEPWQPHVDYWDHEGGAERLAQNLRESGYGDITADDFPGGSGLAWEEVTAIPHTGTHVDAPWHYGPESEGEPSKTIDELPTDWFCGEAVVLDFTWKDNGAEIQPHEIDEQLATIDHTLSAGEIVLIETGADELWGTSEYLTDFPGMGAKATKHLVDQGVKVIGIDAYGFDKPFETMGERYKETEDTSELWPAHLAGREAEYCQIEKMANFDELPQRTGIHLVTYPIKIENASAGWARPVAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0L7</accession>
    <name>A0A3N6P0L7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88048">
        <property type="protein sequence ID" value="RQG88048"/>
        <property type="gene ID" value="EA462_14455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="154" mass="17287" checksum="3E2F361EA54282A6" modified="2019-02-13" version="1">MEVEETVSVPTDRETVIEQMQRPDVLERVIPNCTGVEEVDKRVYEAEVSESVSRVSLDLEVDLEVTEFNPPDSFVVSVDGEAPGSNTQVQAEARYELEENDDQTDIHQTMTIDVSGKLASLGFRMLRSTVNKRMQTMVDNVQAEFEEPTSTVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1E8</accession>
    <name>A0A3N6P1E8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88895">
        <property type="protein sequence ID" value="RQG88895"/>
        <property type="gene ID" value="EA462_10890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="127" mass="13306" checksum="B67EF5277FC9983B" modified="2019-02-13" version="1">MSATNPNATRGCPSDDSPIDPLAVLGALDDDACRAILEATSDESLTATELSDRCDIPASTAYRKVEKLADAGLVEERVRINTSGKHATEYRKSFDDVVVSVADGESIEIEMTSATVESDAASPVAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1Z4</accession>
    <name>A0A3N6P1Z4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89145">
        <property type="protein sequence ID" value="RQG89145"/>
        <property type="gene ID" value="EA462_12295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043953">
        <property type="entry name" value="DUF5784"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19096">
        <property type="entry name" value="DUF5784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="335" mass="38267" checksum="CDD430E4F7570794" modified="2019-02-13" version="1">MARPLRFRYSPATWSEQRVRQEILQPLRSNIGARTIAPWFDIGTDWETHRFEMKNGDIALFARNDEEAYWMGNTETPSSLWKTNKFAWTDVPYHVSRWAQRELLATLHEEDRWLEDYPHISWYFLPVFMSKDGRESTRAFFREHAAGFPDAGRREATRFFEEFFATGVLDEYRHVMSGKLGTSNHVDRVRMSAAMGEFIAAKILTDADYEITPEIEVTTGHSLDYRAEDSATNILVEVTRPQPPKNRAAAGPVAAVRDTAETKVNGQLAEHGGGAVLFVDCSSFRDDVWNAVRGEQPDVRHRPAVVYRARPDGHVEGYRKGSVPIELEDAIGFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P416</accession>
    <name>A0A3N6P416_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cadmium-translocating P-type ATPase</fullName>
            <ecNumber evidence="7">3.6.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cadA</name>
        <name evidence="7" type="ORF">EA462_09035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.3" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90125">
        <property type="protein sequence ID" value="RQG90125"/>
        <property type="gene ID" value="EA462_09035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="6">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="6">
        <location>
            <begin position="90"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="854" mass="90292" checksum="A01CA2D70320114B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P613</accession>
    <name>A0A3N6P613_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF547 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91145">
        <property type="protein sequence ID" value="RQG91145"/>
        <property type="gene ID" value="EA462_03880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF547" evidence="1">
        <location>
            <begin position="44"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="244" mass="28026" checksum="4E00DAD55A67EC45" modified="2019-02-13" version="1">MATQLDPHSLSADLLYSVKTEGDVDWLCEQLAVLERPQLERALSSRMDRLSFWLNCYNAYGQLLLEDEPSLLDGSLLDRWRFFRREQIRVSGVRVSLNDIEHGFLRSSKLRWGGGYLPRPLPSSFERQFRLEECDPRVHFGLGRESGSHPPTAVYSPNAVDDELDTVVTWSLEQNVEYDPDENVATVPQLFRTYRGDFGRKRGILDFLLTYDAIPSDRTPSLVYRAAQNTIEFPLETDVDDPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6K9</accession>
    <name>A0A3N6P6K9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RDD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_05750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91465">
        <property type="protein sequence ID" value="RQG91465"/>
        <property type="gene ID" value="EA462_05750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RDD" evidence="5">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="142" mass="15107" checksum="DF73160DC6E69A4C" modified="2019-02-13" version="1">MEKHPAPQMGTNGDVIGKRFLAFILDSIIMGLIAGVLIGIGFVLGDIGVMLMSLVAFAVSIVYVFLLEGMYGYTPGKHLLGLVVVKTDGSDCTIGASVLRNLLIIVDSLPTAYLVGIILILVTDENKRVGDFVADTVVVNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9L4</accession>
    <name>A0A3N6P9L4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92935">
        <property type="protein sequence ID" value="RQG92935"/>
        <property type="gene ID" value="EA462_01565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="78" mass="8549" checksum="2FA9BEB4C7A2EFEE" modified="2019-02-13" version="1">MEQQLTTDRSTVIPTELDSPQGKLVYLYLDATSGATLTDLNRTLAMNKMSILSVLDTLSSDALVEKRGDEYVTIPAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9Q0</accession>
    <name>A0A3N6P9Q0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_01935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92995">
        <property type="protein sequence ID" value="RQG92995"/>
        <property type="gene ID" value="EA462_01935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="93" mass="10637" checksum="947FF3C454A262CA" modified="2019-02-13" version="1">MGSLLSEDEIDEQLPDDWDRDGDEIVRTYEFDDYLRGVNFAQMVGEIAESQFHHPEIVIGYKEVEIRLTSHEEGGITDDDTEMASLIESERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9S8</accession>
    <name>A0A3N6P9S8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="12">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alpha-IPM isomerase</fullName>
            <shortName evidence="12">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">leuC</name>
        <name evidence="15" type="ORF">EA462_02140</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="12"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93035">
        <property type="protein sequence ID" value="RQG93035"/>
        <property type="gene ID" value="EA462_02140"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10 12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="14">
        <location>
            <begin position="8"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RQG93035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="473" mass="51662" checksum="F9B614E89F462978" modified="2019-02-13" version="1">MSEGTLYDKVWDRHKVTTLPTGQDQLFVGLHLIHEVTSPQAFGMLRERDLEVAYPELTHATVDHIVPTSDQSRPYDEDAAEEMMSELEENVREAGIDFSDPTSGDQGIVHVIGPEQGLTQPGKTIVCGDSHTSTHGAFGALAFGIGTSQIRDVLATGTLAFEKQKVRKIEVDGELGEGVEAKDVILEIIRRLGTEGGVGYVYEYAGSAVEDLGMEGRMSICNMSIEGGARAGYVNPDETTYEWLEGTDYFQENPEQFDELKPYWESIRSDDDAAYDDVVTIDADDLEPVVTWGTTPGQGIGITEPIPAPDSLPEDKRDTARRAQEHMRVEPGETMEGYEIDVTFLGSCTNARLPDLRRAAAIVEGRQVDDDVRAMVVPGSQRVQRAAEEEGLKDVFEEAGFDWRNAGCSMCLGMNEDQLEGDEACASSSNRNFVGRQGSKDGRTVLMNPQMVAAAAITGAVTDVRDLPEVQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9Y8</accession>
    <name>A0A3N6P9Y8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93125">
        <property type="protein sequence ID" value="RQG93125"/>
        <property type="gene ID" value="EA462_02670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="91" mass="10637" checksum="E0EFC40072BBA6F7" modified="2019-02-13" version="1">MDDLTGFQRDLLYVIAGADQPSGQDVKGEIETYYSTDINHGRLYPNLDTLVNKAFVEKGELDRRTNYYAISERGRQAIEERREWEKQYVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA38</accession>
    <name>A0A3N6PA38_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacterio-opsin activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_03140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93205">
        <property type="protein sequence ID" value="RQG93205"/>
        <property type="gene ID" value="EA462_03140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="218" mass="24271" checksum="C7096AC821841444" modified="2019-02-13" version="1">MQSTDLTFRLPNRMQLPIPVPDSDLEFHREELLSWHVDIETGRVRFLSLIVGDRDAIRETATDLDVVHRFDLTPIDRDTFYAYAVMDVRAADSTLMGAFDAPGLVVVPPVVYTGRETVHVTVLGEPDALTDLVERFPDDVGVEVDRISDHQREAETLAGRLTGRQFEAMKAARAAGYYDVPRTGSLAEVATRLECSESAASTLLRTIESKLVDAALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHH4</accession>
    <name>A0A3N6LHH4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86140">
        <property type="protein sequence ID" value="RQG86140"/>
        <property type="gene ID" value="EA462_16850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="349" mass="39438" checksum="5B3AB817A3234075" modified="2019-02-13" version="1">MLYDHFSDLELRIEDYDLGQRKRETSSGFTRATTIVSLHGDGVTGSGEDVTYDNDAHETLHDAASDLPVAGEYAFDEFSDLLSDVDLFFGDEPGQAIFRNYRRWAFESAALDLALKQSETSLAERIGRTYDPIRFVVSTRLEEPPTGDRIIDWLDRNPELEFKLDPTSEWTADVVERLAATDAVRTLDLKGQYHGTTVDQPADPELYERVIEGFPQALIEDPELNEETRPLFEEAQARVTWDYPIRGVETVEDLPWKPKWLNIKPSRFGSVRSLFDTIDYCHTHEIQMFGGGQFELDVGREHIHAIASLFYPNAPNDVAPTAYNDPDPSGNLPTSPLAPPEIAQGLSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHU8</accession>
    <name>A0A3N6LHU8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86794">
        <property type="protein sequence ID" value="RQG86794"/>
        <property type="gene ID" value="EA462_16815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="2">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="140" mass="15414" checksum="D61802C0851D565F" modified="2019-02-13" version="1">MEIPDDLLCVFSAEVTERGDSYVIEVPERELELGDVDDGAVYRVALVGTQSTAQPNDTAQPNTTTQRDRDGPDPPVEVGDDRTVDIEGTGEQGDGIARVERGYVIIVPETEKGERVVIEITDVKENVAFGEVVERKDYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI21</accession>
    <name>A0A3N6LI21_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86729">
        <property type="protein sequence ID" value="RQG86729"/>
        <property type="gene ID" value="EA462_16465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="6"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="404" mass="43429" checksum="7D3CA278D68335AA" modified="2019-02-13" version="1">MTTERSRSGVSYADLLTNKNFGIIILVSVSATIGTLLPPALPGLATGLGVSEGTIGYVITVYKLPSILIIPVAAAVADIYGRRTVLLPSLILFGGAGTIMFFAQSFSTLLFLAVVLGTGAAAIYPLTVTLLGDFFEGRQNSAGQGIRVGMIGLGMIFVPVATGYLAEIRWNYPFILFLFVFPVVGIVHLSLSEPLPNKIDERTLRSAVTEYAWTIRKKISEPSLAILVFGGFTRGFTRYALVIFVPLFAVSTLEASLFQVGLLLSIPGAVYVVASPFSGELLNWFKRKQVLFASFFVSGFALFLLPFVNNLFVLAILILCHTAGDAVLDPVMKGTVTSLTDNEHRAGIVNTLYVLKRIGQTTAPAVLGFILATFNYSIVFASSAVFVGIYLLLFAFLFSDTVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI63</accession>
    <name>A0A3N6LI63_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86984">
        <property type="protein sequence ID" value="RQG86984"/>
        <property type="gene ID" value="EA462_15140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="118" mass="13585" checksum="539869EAA436046A" modified="2019-02-13" version="1">MSDVNPVERWQAELEEAGELTPEIVERISNLHGDRGVRAIEAVSENRVKAYRDFTIVVGYDDEYIVEDGNCTCKDSEYNLDPEEPTDLCWHALAVAIARRVGHVDYHDMWYSDVRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIW6</accession>
    <name>A0A3N6LIW6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87936">
        <property type="protein sequence ID" value="RQG87936"/>
        <property type="gene ID" value="EA462_13825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="96" mass="10612" checksum="F7575B2E1F71ACA2" modified="2019-02-13" version="1">MLKGSFWYPQTVPRAILLLGVLIMIPLHQSELLGLMSTSTLVFGWVPLQLAYDVTLILSGVVVLYAMYRMAPEPPEEHEPTIESDESEAKPAGGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJD4</accession>
    <name>A0A3N6LJD4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome segregation protein SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88021">
        <property type="protein sequence ID" value="RQG88021"/>
        <property type="gene ID" value="EA462_14290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="376"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="688" mass="78477" checksum="06C6A9E16CB4B9D2" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJE5</accession>
    <name>A0A3N6LJE5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88793">
        <property type="protein sequence ID" value="RQG88793"/>
        <property type="gene ID" value="EA462_10330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="148"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="286" mass="30832" checksum="F4E73647301C18AA" modified="2019-02-13" version="1">MSGDQLLVPVANPETADRLLDTAIDIASDRDLEILVLTVVTVPMQLSLTQARDSLEIDESEALVEDVVERARGYGLEATGRIRFGRDVASGICGVATESNAEVILLGWRGRPRRRDVVLGSYIDEVLSDAPCDVLVKRIDRDRTDVSSILVPVAGGPHTEFAASVAGSLARSHDARIELLTVVPDRTEETISDARAMLTRTSSMLGAVESVEETALEGSVVETIVERTAAHDVTVLGAAEGGFLQRALVGDVPETVGREAESAVIMAKRRQDIPETVIRRLRNRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJU4</accession>
    <name>A0A3N6LJU4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_17145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86194">
        <property type="protein sequence ID" value="RQG86194"/>
        <property type="gene ID" value="EA462_17145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="14"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="153" mass="16873" checksum="C157E48DBDBA8BCE" modified="2019-02-13" version="1">MSHSTQPRSDETLQILLVEDNPGDARLTREAFKETDCETTLHVVTTGDDTLDFLTQQGAYESASLPDLVLLDLNLPGKDGCDVLEAIRDDPQLRPLPVIMLKSSGASEDIARCYNAQANAYLTKPADPAEFTALVEAVEQFRFKQVQLPPLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK66</accession>
    <name>A0A3N6LK66_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagella cluster protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86748">
        <property type="protein sequence ID" value="RQG86748"/>
        <property type="gene ID" value="EA462_16570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="218" mass="23792" checksum="6ACC9D755E59B076" modified="2019-02-13" version="1">MPDSNKEKNPKEKADVPPVLPGEQPKPSGSGGALSPEELDFTDSPYVSKVSEGRYVVSSEKRPSGVPDTTTGSNRTPPQPQNQPHRQHDSATNRANVSERPAGDGHQPIQSPEVARSVLADELDRTDARFALDIIAQFDRTAVRHRTSSDDVVGTFNNLVLWYAQHVATETPTQRTASLLIERSEFAPPLSPMQLRQAARKHGLDKSSSLGELLEAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKC5</accession>
    <name>A0A3N6LKC5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpD</name>
        <name evidence="8" type="ORF">EA462_11865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89068">
        <property type="protein sequence ID" value="RQG89068"/>
        <property type="gene ID" value="EA462_11865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="238" mass="27037" checksum="E89EB332C0B42450" modified="2019-02-13" version="1">MANDVKPTRKNLMEIEDRIELSERGHGTLEKKRDGLIMEFMDILDKAQDVRGELSDDYESAQKKINMARAMEGDVAVRGAAAALQEHPEITTESKNIMGVVVPQIESSRVSKSLDERGYGIMGTSARIDEAAEAYEDLLESIILAAEVETAMKKMLREIETTKRRVNALEFKLLPELYENQEYIEQKLEEQEREETFRLKKIKEKKEQEEKDERAAEAEREADEAEMEQATAGGVPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKK1</accession>
    <name>A0A3N6LKK1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89188">
        <property type="protein sequence ID" value="RQG89188"/>
        <property type="gene ID" value="EA462_12540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="40" mass="4234" checksum="C8FB71EB9C8FEF87" modified="2019-02-13" version="1">MIVMATAGRTGTSRELIGSVAERVVRSSPVPVVTINADEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLX6</accession>
    <name>A0A3N6LLX6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_08615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90053">
        <property type="protein sequence ID" value="RQG90053"/>
        <property type="gene ID" value="EA462_08615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="106"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="309" mass="34396" checksum="54561EC737017156" modified="2019-02-13" version="1">MSVKDHLPTAVESRLSSSRAISQLKDGLRTAFELYRSDRLGQFGLVVLTAFIFVAVFAPILAPYNPGERHRRSDGSLARLDGPSADHLLGTTHHGQDILSQVLISSRVSVFVGFLAAFIAVFIGTNVGLLSAYYGGWVDDLLMRIVDIAYGLPFLPFVIVLVFIFGANIVNIMLVIAAILWRDSARVVRSEVLTQKQRPYVESANAIGASDFRILYRHVFPNVLPLTVLYMAFAVAYAIMYEASIAFLGFGDPNVYSWGRMMYQAYTHGAIREAWWWVLPAGVCIMLLVSSVFFIGRTLEEITNPEIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLY9</accession>
    <name>A0A3N6LLY9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">gcvH</name>
        <name evidence="6" type="ORF">EA462_08725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90073">
        <property type="protein sequence ID" value="RQG90073"/>
        <property type="gene ID" value="EA462_08725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="124" mass="13897" checksum="F2ECEB293B8F9D62" modified="2019-02-13" version="1">MEFTIPDELLYEESHEWVDEGDGAVRIGITDFAQDELGDIVFVELPSEGETLERGDEFGLVESIKAVSDVYVPVAGTVTETNDEIIDRPELINEDPFGDGWMIELETTDTVDHLLDADEYSEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM37</accession>
    <name>A0A3N6LM37_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90028">
        <property type="protein sequence ID" value="RQG90028"/>
        <property type="gene ID" value="EA462_08460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="6606" checksum="2395056F8B31E19A" modified="2019-02-13" version="1">MANRDDVTRELARCTECGSVYAARQWPGGTIQPIGAGNCDCGSTNFVLVTDAGEDPSTGGVNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMB5</accession>
    <name>A0A3N6LMB5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90138">
        <property type="protein sequence ID" value="RQG90138"/>
        <property type="gene ID" value="EA462_09110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="73" mass="8239" checksum="10AD575CCEC46318" modified="2019-02-13" version="1">MDSNHTSSPPTDATERFERDLEELITTAFARGAAVEATWMVTTPVADAPDWSITIEKEYSRTESGFEPRFLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMD0</accession>
    <name>A0A3N6LMD0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88947">
        <property type="protein sequence ID" value="RQG88947"/>
        <property type="gene ID" value="EA462_11180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="155" mass="17066" checksum="440F7E47BCF50000" modified="2019-02-13" version="1">MDVTADELAGVVDLFGGLTRSELERALSEAAFRADGTSVDEAAVEAAVEDALESFALVSDDREGKPLLVAGPTAFPTVPDHAEDVPHILDVDRRRLDREALGESTRRRFSEALEAAIEDEDDDRLRQLLDVTYDVEAWAPIDLTDERTRLEAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LN90</accession>
    <name>A0A3N6LN90_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87055">
        <property type="protein sequence ID" value="RQG87055"/>
        <property type="gene ID" value="EA462_15575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="36"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="28734" checksum="8FE2E89DEA6676EC" modified="2019-02-13" version="1">MREFSESYLERTRDGMWDDSRAALEPLALESCNRILDVGCGTGELSRVLDAESNAEVVGCDADPTLLGAASERVSVVAGDAHRLPFADDSFDLVVCQALLINLPDPAAALAEFARVSSDRVAAVEPNNAAVEVDSSVTSERALEKRARNAYLDGVGTDVSLGSNARSAFESAGLDELETRRYDHVRTVEPPYSDAALLAARRKATGSGLADDRETMLAGGQTEVEYDELRGAWREMGRDVIDQMEARTYRREEAVPFFVTVGQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNF5</accession>
    <name>A0A3N6LNF5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_15835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87145">
        <property type="protein sequence ID" value="RQG87145"/>
        <property type="gene ID" value="EA462_15835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="137" mass="15217" checksum="85614611B5245292" modified="2019-02-13" version="1">MNDWIAIGALAFVGLLIPLGMMAVSYLLRPSVPETSKRATYESGEIPTGGTRIRFNIQYYMVALLFVIFDIETVLLFPWAVVYLDAIESDAVTLLEILGPMVAFVVILLVGLAWAWRNGAVQWAETPRQVETDGNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP18</accession>
    <name>A0A3N6LP18_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87977">
        <property type="protein sequence ID" value="RQG87977"/>
        <property type="gene ID" value="EA462_14055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="12"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="290" mass="31417" checksum="159BF97C63705D06" modified="2019-02-13" version="1">MTDAASLPEGTRVGRTALLVESLEEPIEFYRDVVGLALLSAGETTATLGVDGTPLLVLNRDEEASPRTREQAGLFHTAFSVPSRASLGDALERIRDRWRLDGASDHHVSEALYVTDPEGNGVEIYCDRPAGRWPRTDDGRVRIGTVPLDLEDVAAESSGSARMPAGTTVGHVHLEVSSLEATRAFYVDTIGLCVQTDVGSAVFLAAGDYHHHLGVNAWNDRSSPAGGRGLAWFELVVPDEESLSTVRRRLERTAATVSGRSDGFEVLDPDEIAVRFRAEPSRSERRGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP36</accession>
    <name>A0A3N6LP36_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF58 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_04110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91183">
        <property type="protein sequence ID" value="RQG91183"/>
        <property type="gene ID" value="EA462_04110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="286"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="4">
        <location>
            <begin position="424"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="671" mass="71443" checksum="294B39E7645957FB" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP64</accession>
    <name>A0A3N6LP64_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_07700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89887">
        <property type="protein sequence ID" value="RQG89887"/>
        <property type="gene ID" value="EA462_07700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="560" mass="58224" checksum="0B5489C29D931AA2" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPD6</accession>
    <name>A0A3N6LPD6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterio-opsin activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_04805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91308">
        <property type="protein sequence ID" value="RQG91308"/>
        <property type="gene ID" value="EA462_04805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAT" evidence="4">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="159"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="214" mass="24644" checksum="3D7D635A931DA547" modified="2019-02-13" version="1">MSLVAEFEARSPRFLLGSTLEAMPSLAVDLERQYALDPKRPIAFCWVRARNRNRLESALDSDRTVNEFERICHREDRTLYRLRQAGSGVQAYRRWVSDGGQLLECRASEGGWVIEMRFPDRESFVRYHTFLEDERVEFELLRLADGTDVVSSHASRTVTESQREALEIAHEYGFFDVPRGTDLATIADHLGISTQAVSERLRRGQARLVENYVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ11</accession>
    <name>A0A3N6LQ11_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90307">
        <property type="protein sequence ID" value="RQG90307"/>
        <property type="gene ID" value="EA462_10040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="251"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="384" mass="40586" checksum="922CCE512B7006CE" modified="2019-02-13" version="1">MERVAIIGASMTQFGQRDDWILDLLAEAGIECLEDAGVSAADVDHLYVSNMASGEFEGQTGVVNALAHDLDAVPAYTQRVDQTSSSGGAGIYAAWQSVASGASDMTLLVGGEKMTHRTTGESTDVIASLTHPVEYKQGVTLPSFAGLTARHYLERFDAPRESLAKVAVKNHANGVDNPHAQFQKEVDVETVLESPIVADPLRLYDFCPITDGSAALLICPESVASEYTDEYAVISGIAGATDTHVVHERMDPTVMGGVVESGENAYEMSGYGPDEIDVAELHDMFTILEFLQMEGLGFAAQGEAWTLVEEGYTEKDGELPINTSGGLKSKGHPLGASGVAQGVEVYEQLVGEAGSRQVDADVGLSCNVGGFGNCVITTIMEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ32</accession>
    <name>A0A3N6LQ32_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91678">
        <property type="protein sequence ID" value="RQG91678"/>
        <property type="gene ID" value="EA462_06960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="84" mass="9537" checksum="CCC5067AB7A7FFFA" modified="2019-02-13" version="1">MTDETPNSESGNDTSKPSKKTLKPNKLKIKACDLEVEAESNEETVEEIVGYLSPKMESLMRHHLAGQLCHFYFPHFLYVLLTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRL3</accession>
    <name>A0A3N6LRL3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalamin ABC transporter permease BtuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">btuC</name>
        <name evidence="8" type="ORF">EA462_07130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89784">
        <property type="protein sequence ID" value="RQG89784"/>
        <property type="gene ID" value="EA462_07130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="366" mass="37850" checksum="ED7550E94E45DE40" modified="2019-02-13" version="1">MMRPVRTLSWTVGLVIVLIIVAIASAALGPVTIDAVVVAKAVLNAITVPTGLTMEEPVTVPGFGWTVHGPRLEYAAVFGFDVPETHQTIVADIRLPRIVLASVVGFALAAAGTVMQGFFRNPLADPSIIGVSSGAAAGAVAAIAFPALVPFGGLHLSAFVGALVTAFLVYAIATDGGRTPVATLLLAGVAIQAFLGAMISYMLVHSGDDLRQAIIWMMGHLHNSTWSDVGFALPVTLVGVLVLFAYTRELNVLLLGEEDAHHLGVDVERTKLLLLALASVVTAAGVAVAGVIGFVGLVVPHIMRLIVGPDHRILLPTSALAGASFLVATDTIARAGPAEVPVGIVTAALGAPFFLFLLVRREVHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS13</accession>
    <name>A0A3N6LS13_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose-6-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91277">
        <property type="protein sequence ID" value="RQG91277"/>
        <property type="gene ID" value="EA462_04620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="541" mass="61537" checksum="92FBF54AD58B73FD" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS49</accession>
    <name>A0A3N6LS49_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_00230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92698">
        <property type="protein sequence ID" value="RQG92698"/>
        <property type="gene ID" value="EA462_00230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MUTSd" evidence="3">
        <location>
            <begin position="72"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="4">
        <location>
            <begin position="390"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG92698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="593" mass="64240" checksum="309BEC01AE42A88C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSD1</accession>
    <name>A0A3N6LSD1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90174">
        <property type="protein sequence ID" value="RQG90174"/>
        <property type="gene ID" value="EA462_09300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="69"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="161" mass="18258" checksum="6988BC2C3454F8AA" modified="2019-02-13" version="1">MSEREVLESLRENARYSTADIARMTDLDESEVDAVIEELEDAGVICGYQPVVDWDKLEDERVRAEVELNVRLDRETGYGDIAERLARFPQVTALRLVSGDYDFDMEVEGDSIREVSQFVSEKVAPVPEITQTVTHYVMTSYKENGIELGNGDEDDRLSFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSJ0</accession>
    <name>A0A3N6LSJ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92913">
        <property type="protein sequence ID" value="RQG92913"/>
        <property type="gene ID" value="EA462_01440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="73" mass="8817" checksum="AE5F38A6C051D239" modified="2019-02-13" version="1">MRYERERRRGRSELRNKEETEIPIGEPLDSAGRGYSMWRCWNCGEMGRLEERLPETCPSCAAPREELYYWEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSR5</accession>
    <name>A0A3N6LSR5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90374">
        <property type="protein sequence ID" value="RQG90374"/>
        <property type="gene ID" value="EA462_08995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039651">
        <property type="entry name" value="FixC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624">
        <property type="entry name" value="PTHR43624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="10"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="559" mass="60731" checksum="D08A58CEB0553EB0" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSY3</accession>
    <name>A0A3N6LSY3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93118">
        <property type="protein sequence ID" value="RQG93118"/>
        <property type="gene ID" value="EA462_02625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="312" mass="33561" checksum="4A420F76EFDC39FD" modified="2019-02-13" version="1">MDLEAPADAWYVWIGVSAASIVIAGVVLGLPTGPPPDANAAANAIDRVAGSPYSASVVHQYEADEIRLQEGKTVVLRNDHGDAHSSIAFGSVVLVTDDERLENVTGGTPFHDEFESELDRTDVDGTAEFLARIADSRADTDGEWHPAGERLIVRNVRVPPDEATPQPRITAEVTDVLGDWEDHEPPSAHHATAVRFDYDGDGGDDAVLSARGVSHGGPGEVEYDATTTFQHRADSDVLEFAGADALRLPIDVDVTIDDDRTCSAEDITAYRDPVTLCDGREIRDPDEFAAETPQIEIDPETGEYHVTLVVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LTA3</accession>
    <name>A0A3N6LTA3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two pore domain potassium channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_00600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93278">
        <property type="protein sequence ID" value="RQG93278"/>
        <property type="gene ID" value="EA462_00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0407">Ion channel</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="3">
        <location>
            <begin position="82"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="334" mass="36349" checksum="9BF824FD394257B6" modified="2019-02-13" version="1">MQPLLLAAGLALLGIVIVDLLWTTLWVDGGSGPLSSRLTSWVWRGLRRASGDDSRILSLAGPLIMGLSLAMWIGLLWLGWTLLFAGGSVALVSAHTGEPADWIGRFYYVAYTMFTNGNGDYTPTSGRWEIASSLTTATGMAFVTLAVSYVLSVLGAVSQKRSFASDVTGVGERGEAFVRTSWSDDGDVSRGLELSLESLSSQLSLLAQQHKSYPILHYYHSEQSADASAVAVPILDEALTLYRHGLPDDEKPDPMLLEDGRSSVGSYLETLETAFIEPAEEAPPPSDLDRLREDGIPTVSDGEFEGSLEELRERRRKLRGVLEADAWEWPPVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV26</accession>
    <name>A0A3N6LV26_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="2">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="2">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="2">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="2">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="2" type="primary">folD</name>
        <name evidence="5" type="ORF">EA462_05900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="2"/>
    <dbReference type="EC" id="3.5.4.9" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91494">
        <property type="protein sequence ID" value="RQG91494"/>
        <property type="gene ID" value="EA462_05900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="3">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="4">
        <location>
            <begin position="122"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="297" mass="31274" checksum="D4DBE321885630A9" modified="2019-02-13" version="1">MTEIIDGNAVASEIRDGLTGSIEALADAGARPGLATVLMGDDPASETYVNMKQRDCEEVGIESVHVDVDGDASPETLYDSIADLNDNPDVHGYIVQAPVPDHVDYRDVIRRVDPEKDVDGFHPENVGRLVAGDARFRPCTPHGIQKLLEATEVDTEGADVTIVGRSAIVGKPLANLLVQKADDGNATVTICHSRTEDLAAKTRQADVVVAAVGVPELIDGSMIDDGAVVIDVGVNRVDADTEKGYELVGDVEFETAAENADAITPVPGGVGPMTRAMLLYNTVKAASLQEGVPVDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV55</accession>
    <name>A0A3N6LV55_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2240 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91544">
        <property type="protein sequence ID" value="RQG91544"/>
        <property type="gene ID" value="EA462_06180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018716">
        <property type="entry name" value="DUF2240"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09999">
        <property type="entry name" value="DUF2240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="152" mass="16521" checksum="6C3B626DED0F9126" modified="2019-02-13" version="1">MSLRVAVAAPFIQNGTERLEESEFVVSLSLDRDWFSPDQAKRLIDVATLEGLLEHEEGDLVVAFDPAAVTVPEEFVPDEELLCERSAFERVLDTLVADGTEKHDAVGAINSLQQELGLTIEAAAVVYASREGVDVSDLVPIARSTLTDDDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVJ1</accession>
    <name>A0A3N6LVJ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_06260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91724">
        <property type="protein sequence ID" value="RQG91724"/>
        <property type="gene ID" value="EA462_06260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="415" mass="43435" checksum="5E4F3D439FF6B572" modified="2019-02-13" version="1">MSDRSELSGWLSERPGLTAVAAASATLGLLIVLPYLQYVLLGLILAYILVPAQRRLERYVGAMIAALTLVVVAVLAIILPLAYVLAIAFREALEIVTAVEEGSLSVDAIESRLEETGYAVDLVELSQTYQEPIAGGLQGVVTRGMELVTGLPNVLIGLTVTLFVLFALLRDREALVTWFERVLPMDDDIQRELHTELNQLMWASVVGNVVVAGIQAVLLGVGLALLGVPAVIFLTVATFVLALLPLVGAFGVWVPVALYLVAIDQPLVALTLVVYGSLVSASDTYLRPALIGRTSAFNSAIVVVGIFGGIVVFGAVGLFIGPVVLGGAKITLDVFARERANAIGLEAEETAADPAVDTAPGTGVESETTATDRDEDGTETGDDPGTTSGGGGTRETDSDRGPKSTERASGDHDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVP3</accession>
    <name>A0A3N6LVP3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92827">
        <property type="protein sequence ID" value="RQG92827"/>
        <property type="gene ID" value="EA462_00955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019292">
        <property type="entry name" value="McrC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38733">
        <property type="entry name" value="PTHR38733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10117">
        <property type="entry name" value="McrBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="428" mass="48154" checksum="E609B780B16D81BB" modified="2019-02-13" version="1">MSSNPDEGEDVITLEERSETDLSDCGLKDDDFHFLEELEHISSASITKQKVEIGPYIGHIGLPSGAFLEVLPKSSLDGFKPLYFLAKAGRISEELVTGSQEIGFSVGESFIEVVGEVYAEEVNRLLQAGIHKQYVPRQAATNHVKGRLRVAEQLSKQEPYATSFESQFNDLTADIPLNQLILFAAVEVARKISDKRVERRLQRQISDLQRVVSLPRTAPHPSQITLTRETQMYKPIVKFAEQILNETYIDTFGQRARLLQSVLINTETLFEEVVYSFVADLIRGSRYIIQGDGDPESSVKRDIGHLLRDKFGNGLQGMQPDVFLRSRGNPVWVADAKWREDSSPKRNNLYQVTSYQRKVGGPAIMFYPEQGGQIETVYELSDDEYDDSSITELRVVEVPLGGESYEEFETKAQNKIRTAMQAQLPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWC2</accession>
    <name>A0A3N6LWC2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Isoprenylcysteine carboxylmethyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_02740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93137">
        <property type="protein sequence ID" value="RQG93137"/>
        <property type="gene ID" value="EA462_02740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="166" mass="18731" checksum="2BB1C021BBD5FF48" modified="2019-02-13" version="1">MVSKRVFLKSALFTILVPGTVAMALPQLLAKYRPHPKLPIEPNVGRVLGGLSIFAGVLVYLRTVFQFGTDGRGTPSPTDDPDDLVTGGLYARTRNPMYIGVLLVILGQAFRQRSVAILWWGVGMWIGFHNRVIGYEEPHLVEKHGEAYEEYRDRVPRWLSFTRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWG5</accession>
    <name>A0A3N6LWG5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93197">
        <property type="protein sequence ID" value="RQG93197"/>
        <property type="gene ID" value="EA462_03085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="60" mass="6664" checksum="206CE36DEF6C3DB4" modified="2019-02-13" version="1">MRLALVLPHFVLISTIGTVAGTGLVWLNHYWSLTARIHQTILSILGIGFTWQLFVLGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWP9</accession>
    <name>A0A3N6LWP9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fosmidomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93307">
        <property type="protein sequence ID" value="RQG93307"/>
        <property type="gene ID" value="EA462_02340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="121"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="229" mass="25457" checksum="822E737028F366FC" modified="2019-02-13" version="1">MLTGLSRLALEVKFLEPARRFYGGELGMAVRERGESELVFAAGDTDLVCRRPTGFPRGGLHTHYALSIPAEEYDEWWESLEESHDLEEMRFGEASSLYLYDPDGNCVELGQRDVPGPGIDGIFEVVLEVESVDRAESFYADLGFETIDTGTERKRVRMDGPMALELWEPQLGLADARGGVHVDLGFDAPDPTAALEAVVDRACRVESLEDGDRTRVVVRDPDGHHLVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWZ3</accession>
    <name>A0A3N6LWZ3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">mutL</name>
        <name evidence="8" type="ORF">EA462_17290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86107">
        <property type="protein sequence ID" value="RQG86107"/>
        <property type="gene ID" value="EA462_17290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="7">
        <location>
            <begin position="220"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="6">
        <location>
            <begin position="511"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="704" mass="75374" checksum="EE8557A2DC81B48D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY29</accession>
    <name>A0A3N6LY29_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate mutase epsilon subunit</fullName>
            <ecNumber evidence="4">5.4.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glutamate mutase E chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glutamate mutase large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Methylaspartate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glmE</name>
        <name evidence="5" type="ORF">EA462_17165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2S,3S)-3-methyl-L-aspartate = L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12857"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="5.4.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methylaspartate mutase GlmE subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.1" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86198">
        <property type="protein sequence ID" value="RQG86198"/>
        <property type="gene ID" value="EA462_17165"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050097">
        <property type="term" value="F:methylaspartate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019670">
        <property type="term" value="P:anaerobic glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00245">
        <property type="entry name" value="Glm_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.970.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01923">
        <property type="entry name" value="Me_Asp_mutase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006396">
        <property type="entry name" value="Glu_mut_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014714">
        <property type="entry name" value="Glu_mut_E_C_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06368">
        <property type="entry name" value="Met_asp_mut_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001495">
        <property type="entry name" value="Met_asp_mut_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01503">
        <property type="entry name" value="MthylAspMut_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="3 4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="L-glutamate binding" evidence="4">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="479" mass="52217" checksum="4F93C777D539B48D" modified="2019-02-13" version="1">MIRDERLRSDELRRIDREIRADWSTGAAVEFEEAIAFHDSLPASKRFADVLESADVPLLQPRAGVPRLDDQIDLLESLRTDGGADLLPTTIDSYTRDNEYEKAAEGLEAARETGEDTLNGFPAVNHGVSGCRELIESIDAPIEVRHGTPDARLLAAITFAGGFQSFEGGPISYNIPYTKRHGLAETIENWQFVDRLAGAYTERGVRINREPFGPLTGTLVPPSIAIAIMLIEGLLAATQGVRSITLGYGQVGNVVQDVAALNALQKLGEEYLPDEVVVTTVFHEWMGGFPPDEARASGVIGLGGMTAAIARPDKVITKSPQEFQGVPTREANAAGLRTTRQVIDMAIEQEIDIDGIDEERALIERESRCLMDAVFDRGDGDIVRGTIRAFDDGALDVPFAPSDSAKGAVLPARDDDGRVRIFEWADLEMDGEIKEIHGARLSRRADTEGRDQSFRMVADDVDAISEGKLIGRPEPRGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY90</accession>
    <name>A0A3N6LY90_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CbaC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92814">
        <property type="protein sequence ID" value="RQG92814"/>
        <property type="gene ID" value="EA462_00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="66" mass="7081" checksum="237666677F6B899B" modified="2019-02-13" version="1">MRISNGALLVVVALTVPLLVELRTVLSWVSVELTVLESTLLGGVLIGTVLVWALWPEDGDTDPSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYC9</accession>
    <name>A0A3N6LYC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ammonium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_15345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the P(II) protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87131">
        <property type="protein sequence ID" value="RQG87131"/>
        <property type="gene ID" value="EA462_15345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="11">
        <location>
            <begin position="25"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="8">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG87131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="577" mass="59862" checksum="0135D89A4478EA4E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYP6</accession>
    <name>A0A3N6LYP6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92994">
        <property type="protein sequence ID" value="RQG92994"/>
        <property type="gene ID" value="EA462_01930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="127" mass="14373" checksum="9CF437D872CA6C57" modified="2019-02-13" version="1">MEGQYVFRVKVRLEPADESVSLEPSSAESTVVLFRRAPEPGTDGWRFFRDSLWRGEVNDQPYARRLAGEWLEAPVVSVSFRELRADEAYVDALEAAIADDLEAFNAENVPEVLSKYFGSSIRILDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYR0</accession>
    <name>A0A3N6LYR0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87813">
        <property type="protein sequence ID" value="RQG87813"/>
        <property type="gene ID" value="EA462_13145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="445" mass="47052" checksum="2F16397D64E7A802" modified="2019-02-13" version="1">MFGLSGREVRFALVISGAHLGQHFLMRLIPPLIPVLAVALEYPLWQLGLLISLFSFGSGLAQAPLGIISDRYDRLYVLPTGITIAGAGYVLFAGATSLGAVVPGITISGYTFTGAFLVMGLAMLISGVGTAVVHPTGYPMITDNVSSDNKGKVLGVFGSSAKFGDAAAPAIVGVLILVLVWSQVLLILGLVGIVLGLLLFLVLRGDEYDTVPAAQQNPDGEDETPTETIWDADKRTYMYPLAIIYLFFVSKMFSGEGVKTFLPAFLVAVYAYSFELMDVQLGPESVANFYFAALLVFSGALQLVIGGITDRIDTRLILLGGISLAAVGFLALSLLELGPVSLLVALCLAGVGIYGLAPARDALISDISPPELEGRTFGYIWTAIMLTGAVMPPLVGYIMETMGMREGFLVLTGGTVVAAGFASLLFFERFYVTESPVHGEPNPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYT4</accession>
    <name>A0A3N6LYT4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-keto-5-aminohexanoate cleavage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87843">
        <property type="protein sequence ID" value="RQG87843"/>
        <property type="gene ID" value="EA462_13325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="314" mass="34665" checksum="2FA199F5861A3A05" modified="2019-02-13" version="1">MWDLPSRNVVLTCSVTGAIHTPTMSQHLPITPDEIVDECVAASEAGASIVHVHVRDPETGEPTSDLELFFEVARRVSDRTDVIVQPSTGGSPTMEPEERVAVVPELEPEMCSCNMGSINYALYPLAERYDDWKHEWEADYLTETKDSIFKNSFEDLDVFLNTMRRHDTVPCLGCYDVGHLYNVRRCLDHGWLDPPIYLEFVLGIDGGIGVDPANLTHMKAVADELFGDAYSFSVIPTGTIPFPLALQSVSMGGHVRVGLEDNLYVEEGVLATSNAELVSKAVDQINSLTDREPATSAEVREFLDLKGRSQTAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZA8</accession>
    <name>A0A3N6LZA8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87102">
        <property type="protein sequence ID" value="RQG87102"/>
        <property type="gene ID" value="EA462_15860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="92" mass="9994" checksum="03743C68ECD47B9D" modified="2019-02-13" version="1">MTYDLLAFGLFAFVTLTSALGVVLLKDPWHSALMLGVALLSVAVHYVMLAAEFVAMMQILVYVGGVLILITFAVMLTQREETDADADEVVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZW7</accession>
    <name>A0A3N6LZW7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87784">
        <property type="protein sequence ID" value="RQG87784"/>
        <property type="gene ID" value="EA462_12990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="370" mass="41057" checksum="D87F3EBD2B212BDA" modified="2019-02-13" version="1">MRIAIIGCGTIAQVMHLPYAAELPELEVYALVDPAVDRAETLAERNGVPHHFESTEELLAQVGGELDAAIVLTPPQAHADAVIPILERDIDVLVEKPLAISPEDADRMVEAADASDSTAMVAYMKRYDPAYERAREEIEKIEEIDLITAYDVDPDHGRILDEVYDTVGGSVPDSFIEASSRKRRDDALSAIGVDDSETDGDDGLADDYDWHLEHICHDVNALRGLFGDVERIDHVDVFADGRYATAHLVYEGGNRCVLDSGLSNRKWFEEWLRVDAPDRAVTIEYSNPFIKNTPTEVSVKQGIETLSETTHTPSYDESFKCEIRHFTRAAAGEAAVETTFAEARDDVYLIADLFRVYDGVEPLGTYHTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M004</accession>
    <name>A0A3N6M004_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87834">
        <property type="protein sequence ID" value="RQG87834"/>
        <property type="gene ID" value="EA462_13270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="1">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="454" mass="49465" checksum="939485425006FD33" modified="2019-02-13" version="1">MESVNPTTEETIDSYAEYTDGEVETALEEADRAFADWSQTEIRERQQLLANAAEILRNNKQEYAELITREMGKPVSQAVAEVEKCAWGCEFYAERAIELLQNEVIGTVPEAKAYVRYEPLGVVLAVMPWNYPFWQAFRFAAPTLAAGNVGVLKHASNVPGCALAIEEVFEKAGFPESAFSSLLIGSSKVDDVITNSRVRAVTVTGSEFAGKAVAETAGRELKKTVLELGGSDPFVVLEDAPLESAVETAVTARNQNSGQSCIAAKRFVVVDEVYDEFTDRFVEGVRELEVGDPLDESTDVGPQARAGLMEELHEQVEQSREAGATVVTGGKPLEGDGHFYPPTVLTDVPRDCPAASEETFGPVAAVIRADDAEEAIEIANRTRYGLGGSVWTEDLERGERLAGRIEAGCVFVNEIVKSDPRVPFGGIKDSGYGRELSQQGIHEFVNEKTVWVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M015</accession>
    <name>A0A3N6M015_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Archaeal Lon protease</fullName>
            <ecNumber evidence="13">3.4.21.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-dependent protease La homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">lonB</name>
        <name evidence="17" type="ORF">EA462_11085</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase S16 family. Archaeal LonB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="13"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88930">
        <property type="protein sequence ID" value="RQG88930"/>
        <property type="gene ID" value="EA462_11085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041699">
        <property type="entry name" value="AAA_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004663">
        <property type="entry name" value="Lon_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13654">
        <property type="entry name" value="AAA_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00764">
        <property type="entry name" value="lon_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="15">
        <location>
            <begin position="236"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="16">
        <location>
            <begin position="524"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RQG88930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="739" mass="80595" checksum="1A6BAC6C18C4F1AC" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M089</accession>
    <name>A0A3N6M089_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87944">
        <property type="protein sequence ID" value="RQG87944"/>
        <property type="gene ID" value="EA462_13865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="70" mass="7347" checksum="9D74D6CABA4819D4" modified="2019-02-13" version="1">MSIEQGSKVAFGTLGRTDRSDDHRRIGSSTSARDGTHDGPGRTGTTITIEESPAVIDTVRSGPSGGYRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0E5</accession>
    <name>A0A3N6M0E5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_12005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89090">
        <property type="protein sequence ID" value="RQG89090"/>
        <property type="gene ID" value="EA462_12005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="508" mass="57726" checksum="2C2B608C9A347DB2" modified="2019-02-13" version="1">MASEHAQNDPSETYDEFETRVERISNVSNAAGILRWDQEVVMPAEGTPARAQQLSTLSSISHELLTADETGRLLEELESADLSADRSAVVREVRRQYDRETSVPGELVEQISTATTNAHPKWKRAKEEDDFEAFAPVLEELVELKREYAECIDPDADPYEVLFSEYEPYIDLETAERVLERLRDELVPLIDAIDDSDSELTTDAFAGAFDDDDQEALARDVLDALGYDWSRGRLDTAPHPFSSGTQFDARVTTRFESEDLLGSITSTIHEFGHANYTLGLPDEGYGTPLGEARDLSVHESQSRLWENHVGRSRPFWERFLPIARERFSELEDVTPEAAYESANQVYDDNLVRVEADELTYHLHIVIRFEIERDLVSGDLAVEDVPEAWNDKYEEYLGIRPETDSEGCLQDIHWSHGSFGYFPTYSLGSVLAAQLYAAAAADRGEFDGRIREGEFADLNGWLRENVHRHGKRYTTPELIERATGEALTADYFLEYVRTKYGELYDLEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M208</accession>
    <name>A0A3N6M208_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence/damage-inducible protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89830">
        <property type="protein sequence ID" value="RQG89830"/>
        <property type="gene ID" value="EA462_07375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="231" mass="24847" checksum="71021EEE0DC5B7F1" modified="2019-02-13" version="1">MNAAVVTVGDELLAGRTTDTNATWLCERLTDRGVSVDRITTLPDRIGDIARVVNEYRAEYDAVIVTGGLGPTHDDVTMEGVAAALGRSLEEHDGALVWLEQEGYSNDDLTDGTADLPAGARALHNDVGVAPGAVLEGVYVLPGVPSEMRAMFETVESEFSGTPTHREVVVIDEPESALLDRVERLRAEFDVSVGSYPGEFVRIAIESTDETSVERATAWLRERSETVSGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2E9</accession>
    <name>A0A3N6M2E9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-ribofuranosylaminobenzene 5'-phosphate synthase</fullName>
            <shortName evidence="1">Beta-RFA-P synthase</shortName>
            <ecNumber evidence="1">2.4.2.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48556"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:82767"/>
            <dbReference type="EC" id="2.4.2.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-RFA-P synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.54" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89980">
        <property type="protein sequence ID" value="RQG89980"/>
        <property type="gene ID" value="EA462_08210"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00065"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004422">
        <property type="entry name" value="RFAP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF6">
        <property type="entry name" value="PTHR20861:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004884">
        <property type="entry name" value="Sugar_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00144">
        <property type="entry name" value="beta_RFAP_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="2">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="3">
        <location>
            <begin position="217"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="327" mass="34237" checksum="2B67ED75329F0C31" modified="2019-02-13" version="1">MSRATVSTGARLHVGFQNLSLARSRLYGGIGIALEEPRVSVIARSADTVIADDPLAGSYATRACDVLDVPGVELGLEEELPRHVGLGSGTQLALSTLAATARAHDLEVSLRELAPEMGRGGRSGVGVATFEGGGFVVDAGHPTTRFTTEPPIEGDWTVPPVVARHDLPSEWRFLVVVPNGDPGRSGEDEDESLRAVIERADPAVADEIAGVITRKLLPAATEGRLEAFGEAIAEIGRKNGSWYTDAQGGVFRPPAGALVEALERCHVLSGVGQSSWGPVVYGLTDRAHAEEAVAAAENALERCGLEGRIVLSAATSTGARIRTDDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M325</accession>
    <name>A0A3N6M325_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90240">
        <property type="protein sequence ID" value="RQG90240"/>
        <property type="gene ID" value="EA462_09660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="134" mass="14266" checksum="E8F313D1749014C0" modified="2019-02-13" version="1">MERFRLALAKGCLVAMGFFLATGVVTGLLPTSLFDRMVSRSLLDYAFLSLTSVLTGVYVVQRTSLTECSGDRCAYGGGAAGFFAVACPHCNAILASLFSATWLATYVDPIRPLLGLIAIALFTVVIASRRSLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4C6</accession>
    <name>A0A3N6M4C6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alanine--glyoxylate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90081">
        <property type="protein sequence ID" value="RQG90081"/>
        <property type="gene ID" value="EA462_08765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="89"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="369" mass="39586" checksum="94AAA2C14BD12BC7" modified="2019-02-13" version="1">MTTDRLRMTPGPTEVPEAVRDRMAEPMPNPDVEPEFFEEYRELTAKLEAIFRADSSEAVDRGPDSELDLLVLGGEGILGLEAAVDSLVGPDDRVLCLSNGLYGDGFAEFVEATGAEALICGVSPRETLAADVIASELEDGEYDVATMVHCETPTGTLNDLEPILDVLDDHGVLSIVDAVSSLGGTPVPAEKIDICLGASQKCFSAPPGLTVCSVSERAWNRIEAVETDSFYTNLEPWRGAVDDEWFPYTHLTSNLAGLDAAADLVLEEGIDSVFERHETAATRCRERAAALGLETYPDDAADSSPTVTALTVDGRAEALQRAMLDEHGIVLATGLGELADDVLRIGHMGHNARLERVDRTMDALADVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M577</accession>
    <name>A0A3N6M577_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91170">
        <property type="protein sequence ID" value="RQG91170"/>
        <property type="gene ID" value="EA462_04020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016300">
        <property type="term" value="F:tRNA (uracil) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032873">
        <property type="entry name" value="Trm9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="PTHR13069:SF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="3">
        <location>
            <begin position="55"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="238" mass="26039" checksum="2BD4D916B792837B" modified="2019-02-13" version="1">MGDRQDRSDDRSRRDTVRDTYDRIASHFASTREYAWPEVEAFVDQQTAVDEGIGLDLGCGNCRHAELLAALDGVGPVVGLDVSRGLLETGRKRAREREFAVGLVQGDAATLPLVDDCVGVGIYVATLHHLPTRESRRRSLDELARVLAPGGRALVSAWSTAHSSFDETEGFDTTIEWTLPDGETVDRFYHIYAPDEFEADLRASDLELLEWELSSGNCYATVAGDGGGGEVDAQSVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M615</accession>
    <name>A0A3N6M615_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Geranylgeranyl reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_05775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91470">
        <property type="protein sequence ID" value="RQG91470"/>
        <property type="gene ID" value="EA462_05775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="468" mass="50792" checksum="93B7898FA63965EA" modified="2019-02-13" version="1">MSTLEQSGTATSSGTRGVDVAVVGAGTAGCYAGATVASEGYDVVILERKSEEEAGHIACGDALKGANAFPDSIPKSQIESAFTNTGVDHGRFEIPQEDTVLEIPVPGELAVIDRWEYGRRIIEGAIDAGAELHYDTVVQDVTQTDDGRVTGVEAIRKGEPLTYEADVVIDAAGSLSVLQDHVDFSGSTFDTNVDYSHFCSAYREIVHVEEPVDWHDALVFKPTERAAGYLWYFPRTETEINAGLGFQMTEEPMKLVDDLKRDLENRPEFEGAEVDDKLGAALPTRRPYDSAVHPGYMAVGDAAGHVNPTTGGGIAGAAYAGQYAAEQAIEGVATGAFDEDVFWRYNERVMDHFGARYAALDVYNILSTAVDVDDLMGLLAAMPGDKLAEALYSGSTDIGLKLKLEALLKSRGHWGTIWNLYQTKRRADDLLEHYESYPSSPDGFAAWQARRDELMEAVYETTGADPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M691</accession>
    <name>A0A3N6M691_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91570">
        <property type="protein sequence ID" value="RQG91570"/>
        <property type="gene ID" value="EA462_06345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="103" mass="11168" checksum="FD601D3879275A93" modified="2019-02-13" version="1">MRARSNSEDRTVGATRTDRNERDGNLVVPVTVVGAVGDIVVFPAETACKTSNAPDSEKFYCTTSIASCLPGIVHSSGFTVAISSKVKYPVREHRRDSVDRYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M706</accession>
    <name>A0A3N6M706_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anthranilate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_03685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91111">
        <property type="protein sequence ID" value="RQG91111"/>
        <property type="gene ID" value="EA462_03685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="4">
        <location>
            <begin position="30"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="3">
        <location>
            <begin position="108"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="360" mass="39405" checksum="F75B0195584CC578" modified="2019-02-13" version="1">MAQATQEFGEWPLKRLMTEVVGSGHKSADDMTREQAREAFQRILAGEPDETTLGAFWLANRWKRNTPEELAAYTDVMREESVVTGEPDCDPVDCGANYDGKHTSAVLGVGAGVVAAAAGTPVVVHSGDRVPTQKATAYKHVLDDLDVRTELEPTESAEMVDETGFGFYYQPAFNPGIDDLSDRRDQMGVRVFVNTVETVANPANADVHLGSFYHLAFAKKMTELLKESAELSFSRAIFFQGMEGYDDVRPGYTKVAEWDGRGEGGSESFDDYEIETGTYGMEMESDDLAVEDVTADSAAITTDVLAGERDDHFADAIALNGAFRMYARQDVDSLEDGLERARDAIADGSARAVLEELQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M789</accession>
    <name>A0A3N6M789_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetyl-D-mannosamine dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.336</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-ManNAc 6-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_12690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate</text>
            <dbReference type="Rhea" id="RHEA:25780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:68623"/>
            <dbReference type="ChEBI" id="CHEBI:70731"/>
            <dbReference type="EC" id="1.1.1.336"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89216">
        <property type="protein sequence ID" value="RQG89216"/>
        <property type="gene ID" value="EA462_12690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="8">
        <location>
            <begin position="335"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="447" mass="48528" checksum="D209EF54AD35B205" modified="2019-02-13" version="1">MKEHERLYSESEHESELDRSIDHVRICVVGLGYVGLPLAYEFSEAGHEVSGYDVDSSKIARLESGVDPTGDVGDDAIDGSSIEFTSDAEAIASAEYVIVAVPTPVDDLEKPNLDLVESVGRTVGTHLEDGTAVVLESTVYPGATKEVFVPAIESTAEMTAGESFGVGYSPERMVPGDEKHDLRNVVKIVSALTDETLTEIASLYESVVDAGVHRAPTIETAEAAKCVENTQRDLNIALVNELAVACDHLDVDTRAVLEAAGTKWNFHEYRPGLVGGHCIPVDPFYLIYQSERNDFSPELMRTAREVNEYVPSHVAEMTVKALNEAGNVLRDSRVLVAGLTYKPNVADIRTSKIGGVIDSLQDYGVSVSGFDPRAETVVTEDEFNIDIQEELSAVGFDGILIGTVHDEFYGLSFGDLAFEMSDDPVLVDIDGVFESQAAEHGFVYRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M889</accession>
    <name>A0A3N6M889_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asparagine synthetase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91581">
        <property type="protein sequence ID" value="RQG91581"/>
        <property type="gene ID" value="EA462_06405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="2">
        <location>
            <begin position="121"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="2">
        <location>
            <begin position="261"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="389" mass="41986" checksum="71C41E2C157432F6" modified="2019-02-13" version="1">MTNAHPLRGGDPTTVRRALTDGDPLPGTSGFAGEVDGRLVRDVLGRVPLFVERTGGSGTRDWEFEPTELEEPVAVPAGAVADVDALAKEPDVSAAFERRWSLPDPDPDSSHDDALERLESAIRSAAESVRSTDRDVAVAFSGGVDSALVAALLDAPLYVVGFPDSHDVEAARTAAAAMDRELTVVTLEPADLERAVPRIVRATGRTNAMDVQIALPLYLVGERVAADGFDALAVGQGADELFGGYEKVVHLDHRVEAETTRDAVREQIRSLPDQLPRDTLAVRAAGLEPVSPLIHDAVVDAALRLPDGLLADEETRKRGFRRVAASHLPETVAMRDKKAVQYGSLVARELDRLARQAGYKRRMDDHVTKYVESLCSERSDDPEALRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8Q1</accession>
    <name>A0A3N6M8Q1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89846">
        <property type="protein sequence ID" value="RQG89846"/>
        <property type="gene ID" value="EA462_07465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="439" mass="47045" checksum="E075494DF039DC57" modified="2019-02-13" version="1">MNSDALATLAVVALLVVSGIGGFAGVGSAASPATTQSSDSYVVEQGELCQPIEPLSTNRTVDSFYDYRNHETNPDSDPEDRQYSSYGTAHLQEDDTSLLMLHEGTDGMSLVVVHDRVHGDSDGGVATFDIVGLPGESEWVVQDDLYEGESNMAEWDDGDGWASASWIWADGRTDGGAINGGLNDEFAVTIHPAFNENSPFYDDDDLYDPEFHEGGEITDWQILSGDSDDPDRTPLPSLEEPVTIRTGTCDDPSITYDRSDDDVTATITDASPEDEFSLEITGESDGVVQFERLELTDLDGDQSFAFEHAAPDGLPASPDDADSLGGLTVTGESTDQPGAVTFSVDAELFDEDDLEPEAIALYEVNGSSWNESETTIHDESGETYQFSASVSSLDGFVVAQQDVEPAEDSQTYPMPGFGAGAAIGVVATLSLLWAVRYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8Y0</accession>
    <name>A0A3N6M8Y0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89936">
        <property type="protein sequence ID" value="RQG89936"/>
        <property type="gene ID" value="EA462_07965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="71" mass="7290" checksum="8D810886AEB5A233" modified="2019-02-13" version="1">MTGYYDIVLGLIPVALLGITAALTLVGISLTTAIPAGAFVSMMIIGHAMFVNTPADSSDDTQSPRPPLNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9B1</accession>
    <name>A0A3N6M9B1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92870">
        <property type="protein sequence ID" value="RQG92870"/>
        <property type="gene ID" value="EA462_01200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="205" mass="22182" checksum="83B0918366AE546D" modified="2019-02-13" version="1">MTSPDGVDDDKRATLRRFAAVGAAAPIAGFSESASAETGESDARDAIAGYLSTTPGAHFSKIRDDLQLGTGETQHHLRRLEELDAIEHYSDGDYKRFVPTGRFDEFERQALGYLRRDTPRGMLVTLLSNPDATAGDLAGALDVSAPTVSKYASELEDAGLLSREDGYAVEQPETVLLLVVRHADSFGDRAVELAQNADEFLEYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBR2</accession>
    <name>A0A3N6MBR2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_03660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91106">
        <property type="protein sequence ID" value="RQG91106"/>
        <property type="gene ID" value="EA462_03660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="214" mass="22325" checksum="019FC64B7E84083B" modified="2019-02-13" version="1">MTDERELTLTVNGTERMIEVEPRRLLVHALRENLDLTGTHIGCDTGNCGACTVLVDGEPIKSCLAFAVQADGSEILTVEGMEELPAAAGELHPLQEGFHEEHGLQCGYCTPGMIIAGKALLDENPDPDEDEIREAISGNLCRCTGYQNIVRSIEYAADELESRAAADGGTPIDSTNSSSLGATGSEGKSIDCGLENCCGGPGVGSGDHDDGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBV4</accession>
    <name>A0A3N6MBV4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl21e</name>
        <name evidence="7" type="ORF">EA462_03945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91156">
        <property type="protein sequence ID" value="RQG91156"/>
        <property type="gene ID" value="EA462_03945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00369">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_L21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_L21e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022856">
        <property type="entry name" value="Ribosomal_L21e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_L21e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="PTHR20981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="102" mass="11334" checksum="D2D21F97396A7E8F" modified="2019-02-13" version="1">MPNSSGPRQGTRNKLSNDPRDRGTSPPQRAIQQYETGEMVHLKIDPSVHKGRYHPRFDGQTGEVVGKQGNAFKVQITDGGKEKTLIVTAAHLRAQDRSEDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC37</accession>
    <name>A0A3N6MC37_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91256">
        <property type="protein sequence ID" value="RQG91256"/>
        <property type="gene ID" value="EA462_04500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="399" mass="45302" checksum="A168DDAA278F7D44" modified="2019-02-13" version="1">MATDHSLSEEGSTSADRHGRDERERTDETRPPTAERTDDGYVIRPYEPGDRDDFLDLYDMVLGERNEEWFRWKYEENPYVDHVPMIVATHGGDLVGTKPCFALELRIDSRTYLGFQPADVMVHPDHRRRGLYSRTTERLKEHYRDREPALFFNFPNEATLSGSLKHGWRIVEEVPTFYRVQRPDALIDREDRLSRLSSAAHPVASAYLRACELLVDRPANVVVHRFDGLPTEQLLELYDRGVPGTIHANRTEPFYEWRFENPHWSYDAYVATRDGEPIAGVVVGTTLDDGSTITCLTDVVPLATTPGRRDGLQAILDRVVADHREADLLATSGRAIPAPLLRRFGFLSDASLPLSRITLPTTQVTYPIATEGGHEWTVGARAVTDPANWTITFAEQDTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC56</accession>
    <name>A0A3N6MC56_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TlpA family protein disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91276">
        <property type="protein sequence ID" value="RQG91276"/>
        <property type="gene ID" value="EA462_04610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="186" mass="19571" checksum="3896BA9CCD5494DD" modified="2019-02-13" version="1">MRRRDVIAGVASAGVIAGGGALAIFGVPSAEELTGTDGDGAVHDPLETETIDAPGSEAGTVLVPEPGRVTFVDIFGTWCAPCIEQMPALAETNERIGDDVQFLSITNESVGENGSITEEELVGWWDEHDGNWTVGLDPAAELTERYLAGGYPSAAVIDESGRLRWSDSGIKTADELVGRIEAVLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCD9</accession>
    <name>A0A3N6MCD9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_05280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91386">
        <property type="protein sequence ID" value="RQG91386"/>
        <property type="gene ID" value="EA462_05280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="374"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="585" mass="64961" checksum="097AB179C116C277" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MD14</accession>
    <name>A0A3N6MD14_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91666">
        <property type="protein sequence ID" value="RQG91666"/>
        <property type="gene ID" value="EA462_06890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="62" mass="6635" checksum="13934E3CF50D959A" modified="2019-02-13" version="1">MHLNDSVTAAGFWLGTLLPVAYLPVFFTGIDSVTMLSVFLGLLAINVLALVVGHEYPASRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MD30</accession>
    <name>A0A3N6MD30_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_03695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91686">
        <property type="protein sequence ID" value="RQG91686"/>
        <property type="gene ID" value="EA462_03695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="169" mass="18689" checksum="A512F945830FA7A7" modified="2019-02-13" version="1">MAATLHTSEGDVAVELYDERAPRTVDNFVGLATGEREWTDPETGDEIEEEPLYDDVLFHRVIERFMIQTGDPTGTGRGGPGYQFDDEFHEELRHGDAGVLSMANSGPDTNGSQFFITLDAQSHLDDDHTVFGKVFDGMDVVREIGDVDTDENDRPTEDVLLESVSVHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGZ4</accession>
    <name>A0A3N6MGZ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoacid dehydrogenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93266">
        <property type="protein sequence ID" value="RQG93266"/>
        <property type="gene ID" value="EA462_03485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="328" mass="35976" checksum="2A4F224D892FDD2F" modified="2019-02-13" version="1">MAAESEQLTLVQAVRDGLHTEMERDEDVVVMGEDVGKNGGVFRATEDLYEEFGENRVIDTPLAESGIVGTAIGMAAYGMRPIPEIQFMGFIYPAFDQIVSHAARLRTRSRGRFTCPMVVRAPYGGGIRAPEHHSESTEAMFVHQPGLKVVVPSTPYDTKGLLTSAIRDPDPVIFLEPKLIYRAFREEVPADSYEVPLGEAAVRREGTDISVYTWGAMTRPTLEAAENLAGEIDVEVVDLRTLSPLPEGAIVDSFEKTGRAAVVHEAPKTGGLGAEIIATLQEESLLYQEAPVERITGFDTPFPLYALEDYYLPEAARIETGIRNAVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MR45</accession>
    <name>A0A3N6MR45_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_16385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86713">
        <property type="protein sequence ID" value="RQG86713"/>
        <property type="gene ID" value="EA462_16385"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="5">
        <location>
            <begin position="3"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="6">
        <location>
            <begin position="105"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PGDH_inter" evidence="7">
        <location>
            <begin position="322"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="528" mass="56408" checksum="7D2F0A429101A081" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRB0</accession>
    <name>A0A3N6MRB0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="11" type="ORF">EA462_16810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86793">
        <property type="protein sequence ID" value="RQG86793"/>
        <property type="gene ID" value="EA462_16810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="140"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="234"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG86793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="321" mass="36161" checksum="0C69B612DE80CB3C" modified="2019-02-13" version="1">MKRLTREKELEEQSAHEETDQEGVRTCPECESSSLTRSPDESEISCEECGLILEEEVIDRGPEWRAFNASERDSKSRVGAPTTQTMHDKGLTTTIDWKNKDAYGRSLSSEKRNQMNRLRKWQERIRTKDAGERNLQFALSETDRMASALGVPRSVREVASVLYRRALEDDLIRGRSIEGVATSTLYAACRMEGIPRSLDEVSSVSRVDRMEIGRTYRYISQELGLEMEPVDPKKYVPRFCSELELSEEVQAKANEIIDTTAEQGMLSGKSPTGYAAAAIYASALLCNEKKTQNEVASVAQVTEVTIRNRYQEQISAMGLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSR3</accession>
    <name>A0A3N6MSR3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87795">
        <property type="protein sequence ID" value="RQG87795"/>
        <property type="gene ID" value="EA462_13055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="130"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="360" mass="39788" checksum="1EDB699D4194D5B4" modified="2019-02-13" version="1">MSREHTDTNDTTSDTGTPVADGSGAPANPLDVLETESDVDTSFGTTQKMKKYLRIYLWEPWQVMRRDWRALVGISILSSYIIIGILGWLFLEPTRMGDGPNQLPWFRSLAHPLGTNLYGVDLMRETIHAIPMILKMMFAGGVFTIIMGTVIGTVAGYKGGTVDKVLSTITDVFINIPGLPLVIVLAVVFTPESAYALGILLTIEYWAGLARAVRSQVLQIRYDEYTEASRTIGLPTGTILLKDVIPHLAPYITIRFVSAMRTVLFSAVGLYFIGVLPEGDTNWGIMLSNAYNNGAMYRPQLLHWILIPSIAIVALSIGMILLSQSLDRVFNPRVREKHKKDDEELLEEEEDVGGKGLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUF6</accession>
    <name>A0A3N6MUF6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_11670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89032">
        <property type="protein sequence ID" value="RQG89032"/>
        <property type="gene ID" value="EA462_11670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="2"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="334" mass="36669" checksum="DCC494544EBDE66B" modified="2019-02-13" version="1">MRTVTTLPSATEMAVALGLEPVGVSHECDYPPAVESLPSVTRSRIDADAESGEIDRQVLEAVEDDGVYDVDVETLADLEPELIVTQGICDVCAVDEVIVADAVERIDADPDVLTTDPHTVSDVLSDLERLGRATDRIERANEVRERLDGRIDRIRERTADLTADDRPRVAVFDWTDPAMIAGHWTAELVEWAGGNYGLASAGDRSRPREWDEIRAYDPELVIVAPCGFSLAQIAENRSDLTGRDGWAELTAVREDRVWAMDGHHLLNRPGPRLVDTLEAIARIVQPTLFDAARPADALEGVAAPFDRLSDRLASEGRLEPETGSERRSTTETEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWF3</accession>
    <name>A0A3N6MWF3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89812">
        <property type="protein sequence ID" value="RQG89812"/>
        <property type="gene ID" value="EA462_07270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="42"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="214" mass="23482" checksum="9F15636048057410" modified="2019-02-13" version="1">MAPPSRRNLARVLESLEDFSDPSPALEQYLTPSDLAAHLCHLARLQGDLDRRVLDLGTGTGMLAIAAAISGADAVVGIDVDPDALELARRNERAVEPGLDSGRTDGIDWVRGDVIRHPFSEEAGTVVSNPPFGAQRGNRHADRSFLETARELSSVSYTIHNEGSQSFVESYAADFGGDVTHAFRAELPIDRRFAFHTERTETLEAEVFRIEWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MX31</accession>
    <name>A0A3N6MX31_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_08610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90052">
        <property type="protein sequence ID" value="RQG90052"/>
        <property type="gene ID" value="EA462_08610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="348" mass="38637" checksum="EE128D7C5C185902" modified="2019-02-13" version="1">MLELTDLHVEYEMEDGGSVKAVNGVSISLEEDKILGLIGESGSGKSTLAKAIIRLLAKNGHVPEGEIDYKGTDLTELSDRAFRKEMRWDEISMVPQNAMNGFDPVYTVGDQIVQAIRTHEDVSKADARERARELFEQLGIDPGRIDDYPHQFSGGMAQRAMIALALCLDPSLIIADEPTTALDVVIQDRILQTLRDLQTEFQSSIILITHDISVVSDICDDIAVMYGGRVVEHADVGTIIKEPRHPYTLGLRNAFPDIEEDDQDLISIPGTPPDLVDLEEGCGFAPRCPFATDECWDVTPEPTEYDDGHIVECHRADEQELLTEKAKQKETWMDDETDAALQVEEAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXV6</accession>
    <name>A0A3N6MXV6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S cluster assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sufD</name>
        <name evidence="2" type="ORF">EA462_08935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90372">
        <property type="protein sequence ID" value="RQG90372"/>
        <property type="gene ID" value="EA462_08935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="1">
        <location>
            <begin position="72"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="404" mass="45091" checksum="AEFCB65EA5B8C68F" modified="2019-02-13" version="1">MSTQVHANLTEEQVREISGGLDEPDWLTETRLEALEALSDLEMPDVIRTPGRDWTNLHELDFESLVDPLNAAENKDQVGPADVDVLPWTQAVDEHEELLKEHFGSVVDPQENYLTALSTALFSTGTVVYVPAGVDAEDVTIRTEQNSRSLFNYTLVVTEESSSVTILERQATGSERDEQYYSGIVEVAAGENSYVQYGGLQNLSEDAYNFTVKRADAGTYATVNWIEGNLGTQLTKTEVSTELNGDSSETQIVAAFYGHNDQHFDLDVKVWHRAEHTTADLVTRGVTDDVSRSVYEGVQDVGRSAWDTSSYQRENTLMLSDESEADASPKLIINNHDTEASHSATVGQIDQEDLFYMTSRGVSPRDARNMLVEGFFVPVLEEIAVDELRDDLEELIRARLRQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4U5</accession>
    <name>A0A3N6N4U5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_03185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93212">
        <property type="protein sequence ID" value="RQG93212"/>
        <property type="gene ID" value="EA462_03185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="21"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="358"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG93212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="452" mass="46891" checksum="414A62ABD96355E4" modified="2019-02-13" version="1">MRPLEHVRLSWRSIRGHKLRSALTTLGVIIGIAAVIAFVTLGASLQAGVIGDISPDDQRNLYGWAADPDVEGGPLAGAQPVVSQADLEELEEFEEVAAAYGYAPIQTQAVSDGDERVAQGDGVVASGPSYVRTADLEEGRQFEMGEREAVLNPAAAGQFEENVSVGDELTVATLGGRETAIEVVGITATSDGLSPFEGFEPSPRIYVPTDPYYEEAAGGVGFGGGGADEGNAGDDGAGDGDASDGGDGSASGVEESNGSLRFLAIVVEAHSPADDDVDAARERTITHLESGEADAGEFLGDDDSLAITLQTSTELLQQLQDVLELLQNFIVGIAAISLLVGSIGIANIMLVSVTERTREIGIMKAVGAQNREILGLFLAESVILGVVGAMLGTGLGLAAGYLGALYIDLPLVYPIEYVTLAIVVGVLVGICSGLYPAWRAARTDPIDALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NTZ6</accession>
    <name>A0A3N6NTZ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86166">
        <property type="protein sequence ID" value="RQG86166"/>
        <property type="gene ID" value="EA462_16990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="16"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="395" mass="41281" checksum="C55976ADED6D7147" modified="2019-02-13" version="1">MPTDGSERPDSRRSWIVAITGAIAMIFTFGTPVSYGIFREPFSDAFGISPVALSGVFAIMLFTFFIGSGLVGVFGVRFPARAVLLVCAITTGVLAPAIYLTESIIGLTVVFAVLGLSLGTVFVLVASVVPRWFDTRSGAATGLIFVGNGLGLFVLPPVWQFALAEVGVRRGFFIIISVSALAFALTGFVCRRPTWVEQSTATADELLEWIARLARMRTFQFLFVGIALSFTWYQLLAAYAVDLFVARGLTEAGASTAFGLIGGVSIISRIGGGYLGDVVGSRKAFLASLVSITAGLLLLFVSAVPTLVIAVFLIGLGLGGTATLYIPLLMSIYSPEKDTAIVGVFNLAGGIAALAMPPLGTITVAYTGDFTMAIALTVAMSVIGFWTVAVGTGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUR7</accession>
    <name>A0A3N6NUR7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86940">
        <property type="protein sequence ID" value="RQG86940"/>
        <property type="gene ID" value="EA462_14880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="216" mass="24350" checksum="D35D3B41EA2075C7" modified="2019-02-13" version="1">MSSPQGWSEVNELPAFFDRLEDSGGIPVREFVAQLDEQHDLDIDADGIVYHDRGIRVPGYDATFVHEPTGSRGRPAFSVQVDTVGPRNAWEIFDDTLTWNAYLLRTEGLAAIAWLSDEEYRVEESDHFESTREAVSAGRFSFGIFLHSGEDWNEQIDRIQRTNAPAFLQREDGSTMLPSTQSEFYQYVDSTPTEFRTSGGNAPSYLGVLELEITID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NV25</accession>
    <name>A0A3N6NV25_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87110">
        <property type="protein sequence ID" value="RQG87110"/>
        <property type="gene ID" value="EA462_15905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="121" mass="13307" checksum="F8CE47FE7F2A340C" modified="2019-02-13" version="1">MADDSDSETPPSFLSSLPDQPITDDIVKQIGESDHPKIHGAMGFPGSTPGTIEVFLLNMEEATHVLVFDSSEERWRANESFDNTDMDHQEMIDHATEIANDWFAESLADRIATAEDADSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWY0</accession>
    <name>A0A3N6NWY0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Peptide chain release factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Translation termination factor aRF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">prf1</name>
        <name evidence="11" type="ORF">EA462_12105</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89109">
        <property type="protein sequence ID" value="RQG89109"/>
        <property type="gene ID" value="EA462_12105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00424">
        <property type="entry name" value="Rel_fact_arch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020918">
        <property type="entry name" value="Peptide_chain-rel_aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PTHR10113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="SSF55481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03676">
        <property type="entry name" value="aRF1/eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG89109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="419" mass="47011" checksum="3CE2219B62E7DAF1" modified="2019-02-13" version="1">MSQEGEQEQSDRKKYEFRKVIEDLTDYEGSGTQLVTIYIPDDRQVSDVVQHVTQEHSEAANIKSKQTRTNVQDALTSIKDRLRYYDTYPPEKGMVLFSGAVDAGGGQTTMVTKVLESPPQPVESFRYHCDSDFLTEPLENMLADKGLYGLVVLDRREANVGWLKGKRIEPVKSASSLVPGKQRKGGQSAQRFARLRLEAIDNFYQEVAGMANDLFVPKRHELDGILVGGPSPTKDEFLDGDYLHHEIQDNVIGKFDVAYTDESGLKDLVDNAEDALADAEVMKDKQQMEEFFEELNAGDLATYGFEQTRRNLMMGAVDRLLISEDLRKDVVTYDCEACGNTDRDVIDRRSSMPEHGCSECGSDVDATEEDREDAIDHLIEIAEQRGTETKFISTDFEKGEQLYNAFGGFAGLLRYSTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYQ9</accession>
    <name>A0A3N6NYQ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3054 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86202">
        <property type="protein sequence ID" value="RQG86202"/>
        <property type="gene ID" value="EA462_17185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021414">
        <property type="entry name" value="DUF3054"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11255">
        <property type="entry name" value="DUF3054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="143" mass="14828" checksum="B04EB00B407480E4" modified="2019-02-13" version="1">MDTLAPTETEGSVVDRETVLVAAVDVALLAALIVVGQRSHGIDPITQPAASLETVAPFVIGWLAVSVLAGLYARGSSMGIVQTTRTVAVVWLAAANVGVLLRASSLFDGSAEWPFPLVITGFGLIVLVGWRIGYAVVTARSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYZ5</accession>
    <name>A0A3N6NYZ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_08925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90109">
        <property type="protein sequence ID" value="RQG90109"/>
        <property type="gene ID" value="EA462_08925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="299" mass="33020" checksum="125FDD778F858F78" modified="2019-02-13" version="1">MARLELRNLHAEVAEGDEKILEGVDLEVESGEIHALMGPNGSGKSTTAKVIAGHPAYEVTEGEVLIHLDANEFGSDVDIDDDQRTWNILELEPNERAALGVFLAFQYPAEIEGVTMTNFLRTALNAKIEEREELFEGADEDDEEAGFESSPMEGPQDDGEVGVAEFQEILAEKMEQLDMDEKFARRYLNAGFSGGEKKQNEVLQAAILEPSVAVLDEIDSGLDIDRLQDVSNGINALRDEQGTGILQITHYQRILDYVEPDHVHVMLDGKIAKSGGPELAEELEDKGYDWVRDEVYGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZF1</accession>
    <name>A0A3N6NZF1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90329">
        <property type="protein sequence ID" value="RQG90329"/>
        <property type="gene ID" value="EA462_10165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="208" mass="21872" checksum="0F14D61252E069D8" modified="2019-02-13" version="1">MGDGSGLKRVVVEEVGNQIDAGDLIGDGSIEAGIDGREVGASVGRSTGERIGRELGESIGRSIHEALEAGLEDEDTDIGSLRSALAEAVRDAIAESIGDNSAGDALESVTEPVTDDEEIPEDEAAGDDDVGDEESTSAPSGDDLEDLKRETLEDFLGLLSYEDLQSIAKDVDVPANLSREEMIDEILEAVSDEYEPIAESDEKSDSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P122</accession>
    <name>A0A3N6P122_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91179">
        <property type="protein sequence ID" value="RQG91179"/>
        <property type="gene ID" value="EA462_04090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043812">
        <property type="entry name" value="DUF5794"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19107">
        <property type="entry name" value="DUF5794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="298" mass="30213" checksum="93E023AB29236385" modified="2019-02-13" version="1">MSTSQHPVALRLERIVGGNTRLLALVMMLPLIDGVFPALILAGALDDPLGAVQVGLLIFGGSATVAVILADMTGTPREQATIVLLVGIPLILLAAIQAALAPAIGSVLDDTIIERFAALVILAIAAKTASATIGEYLPSPAIIIALGLVASIDLNGATLAVMDDPALVANATLAAVVGVGFALAVALSGPYLREYMDLDRFRFGSAVALGLLPLSLLGFAFGQAPLAALVVAALFALDLSFGDDDSESDDDGFFPAVGTGPLADSGLPGSNASESPSDDVDGSSDDDPTETDERAPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1U6</accession>
    <name>A0A3N6P1U6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_11955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89085">
        <property type="protein sequence ID" value="RQG89085"/>
        <property type="gene ID" value="EA462_11955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="136"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="365" mass="40822" checksum="1FCC1B528045E415" modified="2019-02-13" version="1">MSGSSNRRTGRDGNTVDGAVVRYLESLDSGGSKATMRSPLSGFAAFCEREGIESVGTLETSDLREYAFALRERHIEGELKASTANTYFDYTRAFLSFCVREELLDRNPADTNRATEYLPEDKGDRTRQFWTPAQRRGIVAYASKRVDMALDGTIDVSREIAFRDRAIVVLLAEAGVRGAEIFRDTNDDVRDGLHWSDVDLEQKMIRVFGKSRQYEEAALPGAARDALQRYQRVLEPPSDDWPVFPTAHAPSKWGALRAAVDDYDGDRPIDDLLRDHEVVPLALTKEGGRQVMKRLSDEAPIELEDGHDYLQPHGARRALGAELYESGHSELAQSALRHKSIETTHEAYSDIQAADVADSIDEIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P202</accession>
    <name>A0A3N6P202_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91589">
        <property type="protein sequence ID" value="RQG91589"/>
        <property type="gene ID" value="EA462_06450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="63" mass="7103" checksum="5CC54F773A4FDE05" modified="2019-02-13" version="1">MPSIDMYADTTVRADRGECVAATCDNCESDDEIAYTLRTYVDDGSDEQVDLHFCSNDCLRVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P245</accession>
    <name>A0A3N6P245_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91639">
        <property type="protein sequence ID" value="RQG91639"/>
        <property type="gene ID" value="EA462_06740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="15492" checksum="66EF13F993BF196F" modified="2019-02-13" version="1">MPENGRYKFFGVYVSQPVYDALTAYLYEEAGIVDFAEYFDPAEQTIPVGDPGADATAELVSSVVSDFPALYDEAEFDATRDVDPNSFVLVRLAAEPGTVANARERFQAAATVRDTDLRTVQTAVLEAWLSRTDADDRTEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3Y9</accession>
    <name>A0A3N6P3Y9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rubrerythrin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90085">
        <property type="protein sequence ID" value="RQG90085"/>
        <property type="gene ID" value="EA462_08785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="46" mass="4973" checksum="4ED6CC37B78717C1" modified="2019-02-13" version="1">MKDVQLDPEAESAYECFSCGTVVHATAPGSCPKCGADMRNRRTPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P402</accession>
    <name>A0A3N6P402_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA double-strand break repair Rad50 ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rad50</name>
        <name evidence="11" type="ORF">EA462_08900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per homodimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90105">
        <property type="protein sequence ID" value="RQG90105"/>
        <property type="gene ID" value="EA462_08900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03240">
        <property type="entry name" value="ABC_Rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00449">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045171">
        <property type="entry name" value="ABC_Rad50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022982">
        <property type="entry name" value="Rad50_ATPase_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="10">
        <location>
            <begin position="409"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="872"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="209"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="32"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG90105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="894" mass="102812" checksum="C791E3EEB3A05BEB" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6J6</accession>
    <name>A0A3N6P6J6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91435">
        <property type="protein sequence ID" value="RQG91435"/>
        <property type="gene ID" value="EA462_05550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="76" mass="8297" checksum="AB9CE194BEAFB321" modified="2019-02-13" version="1">MREFYTLDTDRSACLHCGSHVTDRFGRVFGNDLDRTHRCGECDGYARSSRGSAAGIEVPIPDPETSPGRHGSEPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6V7</accession>
    <name>A0A3N6P6V7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91615">
        <property type="protein sequence ID" value="RQG91615"/>
        <property type="gene ID" value="EA462_06600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="313" mass="33461" checksum="1CFBCAC881E72AAE" modified="2019-02-13" version="1">MGSPAIRDSTVLVTGGAGFIGSHLVEALDPHNDVRVLDNFSSGDRAHVPDSATVIEGDIGDPIALQRAADGVDIIFHHAALVSVAQSVDAPRRSNRTNLDASLLVLEQARREDARVVVASSAAVYGHPDELPVSETTSRDPTSPYGVQKLALDQYTRLYADLYGLETVALRYFNVYGPRQQGPYSGVISTFLEQARSDEPITIEGDGKQTRDFVHVSDVVQANIQAGTTAAIGAAYNVGTGERTSIRELAETIREATDSSSPIVHRDSRPGDIRHSGADVSRAKHELGFDARVGLESGVRALVDGTELTPRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P8Z1</accession>
    <name>A0A3N6P8Z1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable transcription termination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusA</name>
        <name evidence="8" type="ORF">EA462_00040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in transcription termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92665">
        <property type="protein sequence ID" value="RQG92665"/>
        <property type="gene ID" value="EA462_00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_A">
        <property type="entry name" value="NusA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010212">
        <property type="entry name" value="NusA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01952">
        <property type="entry name" value="nusA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="KH_5" evidence="7">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="145" mass="15586" checksum="9F0686DCB2ED749A" modified="2019-02-13" version="1">MGVTLDDDARRHLALFEDVTGANGVDCLLEERREDGGDRLIVVVSSGQMGEAIGPGGRTIQRYEEQVDAPVRLVEDADNASEFVANALAPAAVYNVTLSENDDIVAYVEVAEEDRGVAIGSNGWTIDAARTLAERHFGIDDVQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P8Z6</accession>
    <name>A0A3N6P8Z6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92675">
        <property type="protein sequence ID" value="RQG92675"/>
        <property type="gene ID" value="EA462_00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="103" mass="11252" checksum="F3EBF08F591A156B" modified="2019-02-13" version="1">MNSPGILWMVQTAAGLSMAGPMFVVGFEFLRGGRTVAGVGFFALGVVALYFPTYLLNRIGGPRAWIRRRLGRSGSDADDTDEEGATTEVDRSESSPLDRLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P909</accession>
    <name>A0A3N6P909_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92695">
        <property type="protein sequence ID" value="RQG92695"/>
        <property type="gene ID" value="EA462_00215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="257" mass="28071" checksum="7C53C8FB2B2AD1E2" modified="2019-02-13" version="1">MTDIAITGASGSVGREAIEALSSDDHDLTLFSHSETDDLETTPIEIAERDAVLEALEGQDVVIHLAANPDPRAKWDAVSGPNVEGLYNVYASALENDLERVVFASSNHAVNMGNTSSPVRPESTVGTPAVVRPADPPDPDTYYGVTKVFGEAMGSYYAKRHGLDVVNLRIGWLLSRKELRSECTERDGAGERYARAMWLSPEDCRRVIEAAATHTLERSPLTAHAISDNAERFLSLAETMLELDYRPRDDSQAVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PAB2</accession>
    <name>A0A3N6PAB2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93305">
        <property type="protein sequence ID" value="RQG93305"/>
        <property type="gene ID" value="EA462_02180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="139" mass="15502" checksum="AF59FFEF3BBE2645" modified="2019-02-13" version="1">MEREQLRAESTLVVTVKSSGELHDDVTDGVETLERGDAVDSTPTLSFTSYDDLMETLTPRVLELIKAIRRAEPASINETARVVDRDVKNVYEELSQLAQLGIIFFEENGQSKRPIVWFDELVITLAFDSETGDRATAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHM4</accession>
    <name>A0A3N6LHM4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3368 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86654">
        <property type="protein sequence ID" value="RQG86654"/>
        <property type="gene ID" value="EA462_16030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021799">
        <property type="entry name" value="DUF3368"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11848">
        <property type="entry name" value="DUF3368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="170" mass="18717" checksum="5BA0FD385FDC8957" modified="2019-02-13" version="1">MWVFDATPLIYLAKVDRLHLVSTLEGQCYLPQQIHSEVVTTGLEEGYTDARRVEQCIDTGLFEVISAGDSQLVGRLQQNPNLSDADVAVLGCTASRDAIAVIDEAYGRTAAEIEGIETRGTAYIVLSRAKYGHIGISEARATIDAMIEEGWYCAPDLYTKLVRKLESFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHQ9</accession>
    <name>A0A3N6LHQ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">asd</name>
        <name evidence="3" type="ORF">EA462_16875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86145">
        <property type="protein sequence ID" value="RQG86145"/>
        <property type="gene ID" value="EA462_16875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="2">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="344" mass="36794" checksum="6DDA2C7E7EDC530B" modified="2019-02-13" version="1">MAVRVGVLGATGAVGQRLIQLLEPHPEFEIAALTASESSAGKTYREAAKWRVDSPIPDDIADMTVTATDPDDVDDDVDLLFSSLPSSVGAAVEPAFCEEGYVVSSNSSNSRMAEDVPLVIPEVNADHLDLLEVQRDERGWDGALIKNPNCSTITFVPTLAALAEFGLERVHVATLQAVSGAGYDGVSSMEIIDNAVPYIGSEEDKLETESRKLLGEFDGASLTHDSVEVAASCNRIPTIDGHLENVWVEAADELTADDAKAAMREYPSLDLRSSPDQFIYVFDEPDRPQPRMDRTLGDGMAIAAGGHRASTFGLQYNCLAHNTIRGAAGASVLNGELLLENGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIP9</accession>
    <name>A0A3N6LIP9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_13170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87816">
        <property type="protein sequence ID" value="RQG87816"/>
        <property type="gene ID" value="EA462_13170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase_2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG87816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="553" mass="61337" checksum="8571063F4FFBA6AB" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIZ4</accession>
    <name>A0A3N6LIZ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87986">
        <property type="protein sequence ID" value="RQG87986"/>
        <property type="gene ID" value="EA462_14100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032836">
        <property type="entry name" value="DsrE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13686">
        <property type="entry name" value="DrsE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="192" mass="20794" checksum="A187C226CC069BA3" modified="2019-02-13" version="1">MSTDTLSTADDGESMGEAELEARVDALEETVAALESDDDDQKKLTIVATQGSFDMAYPPLILASTAAAFGWEVIVFHTFWGLDILHEERSRDLKLSAVGNPNMPMPNALAALPGMDAMATRMMRKKIDENGTATIEELIDLSLEQGVDLQACQMTIELMGYDEEDFYDGVTTGVGAATALQHMAESDIQLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ56</accession>
    <name>A0A3N6LJ56_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2267 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88106">
        <property type="protein sequence ID" value="RQG88106"/>
        <property type="gene ID" value="EA462_14375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="129" mass="14673" checksum="4818533CD6480F5B" modified="2019-02-13" version="1">MNYKEFIGQVQHRLEYAQFGQAVRATRAVLTTLGERLQEGEATDLASPLPMEIDRYLTTADHGQRFDYQEFLDRVATREGVDRSDANYHAQQLLAVVSEVVPPGNLEKVDAQLPEDFEPLFEHVEQAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ62</accession>
    <name>A0A3N6LJ62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxybutyryl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87901">
        <property type="protein sequence ID" value="RQG87901"/>
        <property type="gene ID" value="EA462_13645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="275" mass="29841" checksum="8204D02C119FF5C5" modified="2019-02-13" version="1">MSEADDVPLERVDEEFETVHVDVGDRLENVATVTIDRPDARNALDATVRSELKAAFRAIEGSDVRVVVLTGVDEAKAFVAGADVSELRERDAIEQREVSKRPRVYEVVADLPQPVIGRLNGHALGGGCELAQACDVRIAHERAKLGQPEINLGIIPGGGGTQRLPRLVGEGQALRLILSGELIDAEEAAEIGLVDEVCDDESLDDRVYDLAESMATKSPIALEFAKKAVTASSQLSLESGIEYEAELFSQLFATADKNEGIDAFFEDREPEWEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJP1</accession>
    <name>A0A3N6LJP1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_16920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86154">
        <property type="protein sequence ID" value="RQG86154"/>
        <property type="gene ID" value="EA462_16920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="363" mass="38512" checksum="BC0BCF971CB84D8A" modified="2019-02-13" version="1">MILELENLTHRYGSESAVDGVSFGLESGELVALLGPSGCGKTTIVQAIAGHVRPTSGEVRLRGTAVTDDPPESRTVGLVFQQTTLFPHLTVDENVGYGLAAQGIDRERRADRVGEYLELVGLEERGEAYPAELSGGQQRRVELARALAPQPDVLILDEPLSGLDRALRERMRGEIARIQHETGVTTLCVTHDQEEAMALADRLVVMNDGSLEGVGTPRSLFESPPNPFVASFLGRSNALTGTVVDRGPPTIEVEGATVELDDASRTGSAGDELTCHVRPKDLSLASRGARNSGPSMTGTVTYVADVGRRFDVSLRLESGAELVVEHTGDPPAIGDDRPIVIDPTALTVFDGSSGNDEPTATIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJZ5</accession>
    <name>A0A3N6LJZ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86678">
        <property type="protein sequence ID" value="RQG86678"/>
        <property type="gene ID" value="EA462_16175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="143" mass="17386" checksum="20DFC26C9D6F5D8E" modified="2019-02-13" version="1">MVPVNDGASPAPIDRSVLERMRSRFVGCRMFESVEIAEERKLSLRVELSSEYYPRDASVRFEIRWYRNDDLNIHYREERRDSVWQCRWDRHPNDHNSRDHFHPPPDASRPDAENARWPDDHRDVCRLVFDFVEERIETLWMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK96</accession>
    <name>A0A3N6LK96_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89018">
        <property type="protein sequence ID" value="RQG89018"/>
        <property type="gene ID" value="EA462_11590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="174" mass="19511" checksum="ECC90A862DEF15B2" modified="2019-02-13" version="1">MSTLDRRDIDILFAIANNHTMSTETIHEVTDIPKSTVHYRIQSLKDGGVIVNDLCELAREKIGLEITVISEVWAEYGEGYHEEIGEKLSDIEGVNQVYFTMGDTDFVVIARLTSRDMVEKLVEDYESIEEIRRTSSKFAITTIKETVGVSTLRDYDVETVRAAQGLSEDGEDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKI9</accession>
    <name>A0A3N6LKI9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86958">
        <property type="protein sequence ID" value="RQG86958"/>
        <property type="gene ID" value="EA462_14975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="96" mass="10537" checksum="5CE8B0EE3779BF72" modified="2019-02-13" version="1">MSDDVDTITFSIESEDDVADEVTVPAGLVDLLAEGDQNEAETVADIVLLSFASRAHHLVHHDQGEGEDLEAQEERVMDLFEERFGVTFGEATGHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLX1</accession>
    <name>A0A3N6LLX1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90043">
        <property type="protein sequence ID" value="RQG90043"/>
        <property type="gene ID" value="EA462_08565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="46"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="408" mass="45100" checksum="E25F7F17D7F3D6B9" modified="2019-02-13" version="1">MKVIKDSVHDHIQVNGVARDLIDTPALQRLRRISQLGTVSLVYPSANHTRFEHSLGVYHLACNALEGLAVEGQRAERVQAAALLHDVGHGPFSHNLEELTYRRTGRYHDDVHDLLADGEVGSVLRDHDLEPGTIADLVAGEGRFGQIVSGELDVDRMDYLVRDAHHTGVPYGTIDHGRLVRELTFVDGELVLGEGNVQSAESLLVARALMNPTVYSHSVARIGKAMLRRAAERLLESTDIDADRLQRMDDSDVIASLRATEATAEFSRRLDHRDLYKRAVWAEMDDVPGGIIEADHRTIREFERDIATTADVDPDCVILDVPSRPSMTESTSRVVVNGEVRRLEQQSPLVGALRAAQYSQWRLGVYTPPEFLESVGRAAVSVLGLDIDGALVTEVRDGLDATLDQFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM27</accession>
    <name>A0A3N6LM27_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90008">
        <property type="protein sequence ID" value="RQG90008"/>
        <property type="gene ID" value="EA462_08355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="83" mass="9286" checksum="946A4B0E50B7FB2B" modified="2019-02-13" version="1">MALRKPWRELDRETVASAPDRPGVYELGDGSGTVLAVDHGVLRDELKTVLAYGDADRVRWTETHTLERAQSLAADHRDGTERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM73</accession>
    <name>A0A3N6LM73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90078">
        <property type="protein sequence ID" value="RQG90078"/>
        <property type="gene ID" value="EA462_08750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="102" mass="11010" checksum="0FDA186F92CE4678" modified="2019-02-13" version="1">MDSNGDPTPGSVVAGLHPRFAAGGREHVSENEDSSDELDAGVVRCGTCGSTIGLREYRLTVIVSEDSTAIEHHYCSDTCLPDRGESERADRSSSSEDWSYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMD4</accession>
    <name>A0A3N6LMD4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA (pseudouridine(54)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">trmY</name>
        <name evidence="6" type="ORF">EA462_11235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>pseudouridine(54) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:55292"/>
            <dbReference type="Rhea" id="RHEA-COMP:14140"/>
            <dbReference type="Rhea" id="RHEA-COMP:14141"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="EC" id="2.1.1.257"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the methyltransferase superfamily. TrmY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.257" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88957">
        <property type="protein sequence ID" value="RQG88957"/>
        <property type="gene ID" value="EA462_11235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18087">
        <property type="entry name" value="TrmY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00587">
        <property type="entry name" value="tRNA_methyltr_TrmY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007158">
        <property type="entry name" value="TrmY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40703">
        <property type="entry name" value="PTHR40703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04013">
        <property type="entry name" value="Methyltrn_RNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="198" mass="22001" checksum="65190C69FBF2813C" modified="2019-02-13" version="1">MRQFVLIGHDVPTDPEFSLDDLAGGAGRLDALSRSITAAFVTSHGIRTDVRVHLVVRDELTITFDGHDLRRLNPDERSTAALVKNALEHRDEAIGSLPAEPSPGVELYRRGLEDTLEAIASDGPVIQLHEDGDPISDADPLEEPIFVLSDHQDFTASEQRLLDSWVDRRIRLGPQLLHADQAITVSHHYLDTDGYERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMF5</accession>
    <name>A0A3N6LMF5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase, cytochrome b556 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sdhC</name>
        <name evidence="8" type="ORF">EA462_09855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90273">
        <property type="protein sequence ID" value="RQG90273"/>
        <property type="gene ID" value="EA462_09855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045281">
        <property type="term" value="C:succinate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039023">
        <property type="entry name" value="SdhC_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41910">
        <property type="entry name" value="PTHR41910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="142" mass="15623" checksum="E44C6E20DF46370E" modified="2019-02-13" version="1">MSQSYNRGLVEDFGRWKEFSAGMWAWIFHKFTGWILIGYLFTHIAVLSTAIGAASGDPSLIQQETDVYTTTIQGLESLFIVRVMEVGLLAVAVFHILNGLRLLMVDLGIGLEAQDKSFYASLILTGVITVASVPTFMRGVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMJ3</accession>
    <name>A0A3N6LMJ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90343">
        <property type="protein sequence ID" value="RQG90343"/>
        <property type="gene ID" value="EA462_10235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="83" mass="9389" checksum="6D5AEE70D29494EF" modified="2019-02-13" version="1">MVGVKPLEDLLGEIDRDELDRRICSHPKPRTSREFVCPECEARCTRLLNKDGEAGHAKGCSRRLRRTGSVRKPPMLTDGGERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMR6</accession>
    <name>A0A3N6LMR6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89117">
        <property type="protein sequence ID" value="RQG89117"/>
        <property type="gene ID" value="EA462_12150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="60" mass="6943" checksum="AC4FE14BF1DC4B04" modified="2019-02-13" version="1">MGHQPALLRPTGSRFPFVGRRLEDLFFAFDTFGSDQDSNRRGVDSTERKGQYKDEPVRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMS0</accession>
    <name>A0A3N6LMS0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_12200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89127">
        <property type="protein sequence ID" value="RQG89127"/>
        <property type="gene ID" value="EA462_12200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PTHR13325"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="611" mass="64183" checksum="FA2EE0C0DAAC5D83" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP70</accession>
    <name>A0A3N6LP70_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L7Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ribosomal protein L8e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpl7ae</name>
        <name evidence="10" type="ORF">EA462_04275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit. Probably part of the RNase P complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91213">
        <property type="protein sequence ID" value="RQG91213"/>
        <property type="gene ID" value="EA462_04275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00326">
        <property type="entry name" value="Ribosomal_L7Ae_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_L7Ae/L8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022481">
        <property type="entry name" value="Ribosomal_L7Ae_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000948">
        <property type="entry name" value="Ribosomal_L7Ae_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03677">
        <property type="entry name" value="eL8_ribo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="9">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG91213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="12580" checksum="9E896158F34F5147" modified="2019-02-13" version="1">MSVYVTTDIPADLADDALEALEVARDTGRVKKGTNETTKAIERGNANIVYVAEDVSPEEIVMHLPELADEKGIPVVFIETQDDVGHAAGLEVGSAAAAIVDSGEASGDVEDIADKVEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP76</accession>
    <name>A0A3N6LP76_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase family protein subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88067">
        <property type="protein sequence ID" value="RQG88067"/>
        <property type="gene ID" value="EA462_14555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="297" mass="32074" checksum="E489F3CD03B6EF2C" modified="2019-02-13" version="1">MDNQLASNTTTRVIAQDFDYSAPASLAEALSIRNEYGEDVRPLAGGTDLLIELKADLREEGHLMSLDGVDELNHITDADDDLVIGATVTFDQLIESPLVNDWFPSLSEAASDAGGVQVEKMGTVGGNLCNASPAASSAPPLLNLDARVTLQSEDGERTVPLDEFFTGPKQTLLESDELLTEVRVPKTRFDGWAHEEVKRVTEDLAKAIVSVVVQRDGDVITDCRIGLGCVAPVPMRASNAEAVLNGETFSDDVLARAGATAREEISPISDSRSTSEYRRLITETKIEDLLTEAWDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPI6</accession>
    <name>A0A3N6LPI6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90057">
        <property type="protein sequence ID" value="RQG90057"/>
        <property type="gene ID" value="EA462_08635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="164" mass="18572" checksum="E3D7E5692C7874F7" modified="2019-02-13" version="1">MTEQEPYPRSLGHIGITVDDIEEGVEWYESVLGFTHVMGPEKIHANEGHFGKLVADGMSGFEWMKIAHMATGNQVGVELFEYDTTEGESNPEMMTPGLNHICVQDPNIEELAARIEETGGTQLKDIWKVYPDEEYEMTYCEDPFGNFVEIHTHGYEHGHANMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPU7</accession>
    <name>A0A3N6LPU7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91543">
        <property type="protein sequence ID" value="RQG91543"/>
        <property type="gene ID" value="EA462_06175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="212" mass="22934" checksum="9E6395AD30E8AC4E" modified="2019-02-13" version="1">MAAHGRPALRNLFDESPTPHIAHPPRTHHRDFYVATDGSFRESGGGLGAVIETRDGTRVARVAAADTPPDNNVAEYRALHLGLDILAARAPRDASIGVLVDHDALASNVNNSVLATRHPDGKPPRPVSVPTATGYHWRGIRARLSGFDEVRAARIDSDQNPAHPLANEPDRYRHVNREPDRCVLPDPLESATGEFPPPSRADRNNGGSRASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPV5</accession>
    <name>A0A3N6LPV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91568">
        <property type="protein sequence ID" value="RQG91568"/>
        <property type="gene ID" value="EA462_06330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="15"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="154" mass="17143" checksum="A44D2547CBE71A6C" modified="2019-02-13" version="1">MPSDSADEQSQEPIEILLVEPNPGDSRLFTESFKDAKIVNNLHVVSDGEAALDFVNQRDDYADRPRPDLILLEPRLPGKSGMEVLAELNNEPAFSAIPIVILTSSETEEDIAKSHGLDADQYIQKPVEPDEFIDFVQSVEEFWLAIVHQSAPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ34</accession>
    <name>A0A3N6LQ34_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89034">
        <property type="protein sequence ID" value="RQG89034"/>
        <property type="gene ID" value="EA462_11680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="61" mass="6644" checksum="D452B7AA25837438" modified="2019-02-13" version="1">MATSPNGAGDDVFDQFLTDRGHTVEHVGWEQEYNKKQCPECGGLHESSATDCTVCGWTPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ95</accession>
    <name>A0A3N6LQ95_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89114">
        <property type="protein sequence ID" value="RQG89114"/>
        <property type="gene ID" value="EA462_12130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="178" mass="19485" checksum="C392D9DAE94BF75F" modified="2019-02-13" version="1">MVSRPPQYCPRCGSPLETITFESRERKRCSPCGAVIWHNPVPCAGVAVVDRSRAEPAVLCVERGVPPGIGEWTLPGGHMEIDENPETTAARELEEETGVSVDPDALEILDATALPPQNGKHVTMIHYVVDRAHTEGEPAAGSDASAARFWTPAEFDTADEIFRPIHEDRFRTVADRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQL1</accession>
    <name>A0A3N6LQL1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF373 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89274">
        <property type="protein sequence ID" value="RQG89274"/>
        <property type="gene ID" value="EA462_11220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007254">
        <property type="entry name" value="DUF373"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815">
        <property type="entry name" value="PTHR38815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04123">
        <property type="entry name" value="DUF373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="435" mass="46258" checksum="4F84CF420B11E37D" modified="2019-02-13" version="1">MTTLVVCLDRTDDVGRKTGLRSPIVGWEAVRALVTDIGLADPEDSGVNSLLETLRVAQDLRDEDEDAVVAVVSGDRESMVSADRAVARQLDDLIAAHDPDSAVVVIDSAEDERLVPIVESRVQVDSVDRVVVRQARDIESTYYLLKQFLADEELRQTVLVPLGLTLLVFPVLAMRIGAAEGAAAITTVIGLFLLYKGFNIDEIMTGVAHQVRESLYSGQVSVVTYVVAAGLTFVGLFAGALGVSSLEETPGVVIPIVQFTFDSVPWLAVAALTASAGRLLDETISEEPIRSSFLNLPFAVLAVGMVVRGFSAYFLEQQGLIEPVVVPAIEQGVLSIDSFVVTGGERLALYVVTAIVVSIVGARIAMYFSSANVDAEPDDGMQSESTGRSNAESEVTDGGPRRDDGEPDRAAGSRHEPVSDPSHGSDSDPNPDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS54</accession>
    <name>A0A3N6LS54_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable aminomethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">gcvT</name>
        <name evidence="8" type="ORF">EA462_08730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90074">
        <property type="protein sequence ID" value="RQG90074"/>
        <property type="gene ID" value="EA462_08730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="6">
        <location>
            <begin position="9"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="7">
        <location>
            <begin position="285"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="370" mass="40103" checksum="5B5E535EDA0A44C4" modified="2019-02-13" version="1">MSLQKPPLSQVHQSAGADFTDFGGWEMPVTFDSIRTEHAAVRNAVGIFDVSHMSEVSVSGPDATELMNILTTNDVRTLEDGDAQYSCILDSDGVIIDDIVIYRYPDREGYLFVPNAGHGTQMVDRWSSTASRRELSVTVEDRTMETGLVAIQGPGAIETVDSIGTGSVADLSRFSSMRTEIDGVDCLVARTGYTGEDGVEIFFPSAESTAVWNAFDGVQPCGLGARNTLRLEAGLLLSGQDFDPETEPRTPLEAGLGFVVDLEKPEFVGQESLREQNENGVDETLVGLRVEGRSIARTGYPIEVDGNEIGHVTSGTLSPTFERPIALGYVDSSYADEGTSVDVEVRNRTVEATIIDQRFLESLEPETTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSB9</accession>
    <name>A0A3N6LSB9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91437">
        <property type="protein sequence ID" value="RQG91437"/>
        <property type="gene ID" value="EA462_05570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="69" mass="7317" checksum="2EB5B12AFD01E7D9" modified="2019-02-13" version="1">MDIPTDRLLVMLIVASGLAVLMGGWAGGLVQAETTGWEGIGLRVAIGVVFFAALLGAWIRFSRIDEEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSH1</accession>
    <name>A0A3N6LSH1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92888">
        <property type="protein sequence ID" value="RQG92888"/>
        <property type="gene ID" value="EA462_01315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="91" mass="9800" checksum="AD1FB5BED53ADA6C" modified="2019-02-13" version="1">MFSVSLFRADPASGSVPVSVGVSLMIFLTAATRLIRKTTVPASIGEIVCTTLSLGGRPTTDTYYWLQRGFEEFLDPLAPFARGCNGNVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSN2</accession>
    <name>A0A3N6LSN2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90314">
        <property type="protein sequence ID" value="RQG90314"/>
        <property type="gene ID" value="EA462_10080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="172" mass="18589" checksum="A8EEF25407EAF85F" modified="2019-02-13" version="1">MPVSGQLIDLAFSLLLVFDEPALFLLFVLKGAIIGKVFPTSLFLPGYLLAIKASSEQIAVGIVVASFGYVTGQLLIYWISNNYGTTAVGSLPAVSVSDEQVTRAEELFQRYSGMGIFITNLVPFVGSFIMIPAGMTSYSIPLTILYALSSTVLNYILIVLIAFESLEFLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSP8</accession>
    <name>A0A3N6LSP8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfite exporter TauE/SafE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91557">
        <property type="protein sequence ID" value="RQG91557"/>
        <property type="gene ID" value="EA462_06250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039447">
        <property type="entry name" value="UreH-like_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13386">
        <property type="entry name" value="DsbD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD_2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="276" mass="28247" checksum="141CFF0F8CF82278" modified="2019-02-13" version="1">MDPLSLLGIDVVLFLVIGLLAGAHCIGMCGPLVTIYASRMSGEETSDVPSAGSTGASSNGRAGHLTSYEVRQHALFNIGRTASYTLLGGAFGALGGVLFVTTAQLTPIVDLARGGVGLLIGGFVIATGIYYLLGRTTGGISFPGLERVSGWLAARVDRLASGPGIVGLGAAHGLLPCPILYPAFLYAFATGSPTSGAVALAALGIGTIPAVFAYGTVIDAVDVVHRRRVHRLLGVAFVVLGYVLFAHGLMAVGIHVPHPELPFYEGIDAPGGHDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT47</accession>
    <name>A0A3N6LT47_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argininosuccinate lyase</fullName>
            <shortName evidence="1">ASAL</shortName>
            <ecNumber evidence="1">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">argH</name>
        <name evidence="5" type="ORF">EA462_02995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93183">
        <property type="protein sequence ID" value="RQG93183"/>
        <property type="gene ID" value="EA462_02995"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="74"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="4">
        <location>
            <begin position="387"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="509" mass="53848" checksum="6CAE1FEE85164647" modified="2019-02-13" version="1">MTEESAHDGVSRPETGSTIATDGGERSTDGSDEGVVRRDRFSGGPARSFLSSLEADERIFAADLEVDRAHVVMLAEQGIIDDDVAGDILTALDAIEVDSHGSLPDGEDVHEAIETAVIERIGADGGKMHTARSRNDEVAACIRYRLREDVLAAIETTVALRESLLDVAADHAETVMPGYTHLQPAQPTTVAHWALSYEGAVRRDTARLLEAYDRIDESPLGAAAFAGTTFDIDRERTAELLGFDGIVENSMDAASSRDFLLETTQALSTHATTLSGLAEDVVIFANRGFVSLADDYSSTSSIMPQKKNPDTLELVRAVAGDAAGNVQGLTTTLKGLPRAYNRDLQRATTHAWKTVDAVTEASEVAAGAVATVDWNEESLAAEADAGFSTATGVADLLAANGLPFRTAHEVVALAAERGSDIDAVEAAAQDVLEEPLKSFVDPADVEAALDPTESVGSRDSRGGPAPGAVTANLETARQVRENDEHRLTDEAAALETAHEALRSEVNGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LTC4</accession>
    <name>A0A3N6LTC4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93283">
        <property type="protein sequence ID" value="RQG93283"/>
        <property type="gene ID" value="EA462_00815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="363" mass="39992" checksum="71CA8AB88D94CC4C" modified="2019-02-13" version="1">MYDFVVVGVGPAGARFARRAAEKGFDVLALEKGEIGAPLACSGHVSTDIWQFIGRGARDELFQNEIYGARFHVGGPHSESYPFYKREVASNVIDRVGLDRHLAALADDAGADVRERHTVTAVREYRDRVEVDVSTPEGTERFETKMLAGCDGPRSRVREELELPQPDELLHGVLAFSDEDDHEDFVDVHLTAPTFFAWRIPRGEAGVEYGLAAPPGVQVRRHFEELIDGYEIDVSHRCSGAIPIGPADRVTARRTFLIGDAAAQTKPFTGGGILYGMSCADHAAREIDPDRPSTLPAYERAWRDDLAREMALGRLLRRAYSFPEPIQHVGLGTLSGEIGVHMDRPTSLASPAHLKAMLSRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LU75</accession>
    <name>A0A3N6LU75_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91094">
        <property type="protein sequence ID" value="RQG91094"/>
        <property type="gene ID" value="EA462_03590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="568" mass="59413" checksum="E3F8533117E6540E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV16</accession>
    <name>A0A3N6LV16_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium:calcium antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_05795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91474">
        <property type="protein sequence ID" value="RQG91474"/>
        <property type="gene ID" value="EA462_05795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00367">
        <property type="entry name" value="TIGR00367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="174"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="314" mass="31995" checksum="96FD960918F843B2" modified="2019-02-13" version="1">MFSGTGFSVLVLAAGVVALYVGAELLVAGAGRLAFGIGLRAATVGVTVIAFVTTAPELFVALIGALDVSTDIGLGAVLGSNVANIGLVLGVAALIKPLTVSETVMRRHVPFMVFAALLLAVLGADGTIGRLEGAIFLSVLAGFTGYLLYYVGADPASVVDEPDAGEGIRRRDIALVLGGLVALVVGSRWLVGGGTELLSMLGFSDLFIGLTVLALGTSLPELAASVVGAVRGETGFAIGNVVGSNIYNVLAVLGVVALITPISVASETLRFEIPALILFTVVLVGLMGYDRRLSRLDGGALVIGYCVFVYLLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV83</accession>
    <name>A0A3N6LV83_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S9 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_06365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91574">
        <property type="protein sequence ID" value="RQG91574"/>
        <property type="gene ID" value="EA462_06365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="4">
        <location>
            <begin position="412"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="620" mass="68605" checksum="29036FC6D13CE390" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVE6</accession>
    <name>A0A3N6LVE6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Initiation factor 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_00165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92687">
        <property type="protein sequence ID" value="RQG92687"/>
        <property type="gene ID" value="EA462_00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="459" mass="49322" checksum="B94A06DE3BF2F3AA" modified="2019-02-13" version="1">MTDSTRDDGSEPSHVVTAFVRNRGEILLVRRSDAVGSHVGRWDGVSGFAEGRPDERVRTEIREKTGLEDGVSLVRSGRPVEFEDPDLDRERIVRPFLFDCDTREVKLSDEHDAFEWRSPTATVDPSDGRETVPKLWTAYERVAPTARSVAADDEHGAAFLSLRALEVVRDRAGVLVAERAEGEPDGSERNTHESDGAETRSDAEWNELAELAGRVLETRPSMAVLRNRVNRAMADADRTDDHPPGGAAVLESAISGIERAAAADEDAAVNGGERIDGTVLTLSRSGTVLDALREGSPSRVFVSESRPGREGVGVAETLASDSVLDCSVTVHTDAAAAHVLATEAVDRVVVGADTVRPDGAVVNKTGTRAVSIAAARENVPVTVVAAADKLSTRTTVNLESGDRAAVYDGNPSVDVANPTFDVTPAECVTELVTETGSLEVDELEDIVEELRELETWRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVG2</accession>
    <name>A0A3N6LVG2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92707">
        <property type="protein sequence ID" value="RQG92707"/>
        <property type="gene ID" value="EA462_00280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="727" mass="78445" checksum="627DA9B8A801B986" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVH5</accession>
    <name>A0A3N6LVH5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">EA462_00390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92727">
        <property type="protein sequence ID" value="RQG92727"/>
        <property type="gene ID" value="EA462_00390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="185"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="279" mass="29446" checksum="E99E50FA18FB8583" modified="2019-02-13" version="1">MDAAVGIVAQRGNERAQELTEALVDALGFDREGDDLVVDEATGEAVDATSVPVDAMAGRDLVVSIGGDGTLLFVAREVGSTPILGVNLGEVGFLNAVSPEDAVEAVTTLVEQYRRGNPAEGRTLDRLQATCENDWTLEPALNEIVVHGPRRGHGGGATIEVRIDGERYAENHSDGVLVATPTGSTAYNLSEGGPLVHPSTDALIVTQMAAIDSMPPLVVEPDSELTLTVSDVETAYVISDGRNRRRLEPPVAVSVSLADEPVRLVGPKADFFRGLEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVX0</accession>
    <name>A0A3N6LVX0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_01575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92937">
        <property type="protein sequence ID" value="RQG92937"/>
        <property type="gene ID" value="EA462_01575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG92937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="349" mass="38594" checksum="4EC50559FF105952" modified="2019-02-13" version="1">MPPAIETVDLVKNYGELRAIRELSLTVEEGEFFGLLGPNGAGKTTFINTLVGLVRKSGGEARVFGHDVEDDYQHARNAIGLAPQEFNVDRFFPIREVVMHKAGYHGVPEEEAAERAEDVLKRVGIYDKRHERFDWLSGGMKRRLLLARALVTDPDLLILDEPTAGVDVQLRHDLWELVTELNEEGTTVLLTTHYIEEAERLCDRVAIMNEGRKVTVATPDDLKTRGTDTISVRLESPPTRTPEVGSYSHGTTMSGDRIDVRVDDGGATAPKLLNDLEAAGHEIVDLEIARTSLEDIFVDLTEREDRSVTRSDAETGKKAASETGEGTDESGETDGRSRTQETEEREGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LW03</accession>
    <name>A0A3N6LW03_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92977">
        <property type="protein sequence ID" value="RQG92977"/>
        <property type="gene ID" value="EA462_01820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="129" mass="14304" checksum="F400D9C9305917CE" modified="2019-02-13" version="1">MRIAVTDQPVSPAYPPPWGASELTDSSPFHLLELLVTTDGETRIVTQSSEAHRIGTIAFDDLHREESYGKWSAYGQRKLETLLFAYELERWLEDSGLTETKASPVTPDMPTPICSIVAPANRDRGSGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWH5</accession>
    <name>A0A3N6LWH5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR00725 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93207">
        <property type="protein sequence ID" value="RQG93207"/>
        <property type="gene ID" value="EA462_03155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005268">
        <property type="entry name" value="CHP00725"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00725">
        <property type="entry name" value="TIGR00725"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="150" mass="14851" checksum="D7A6324BBFF92B07" modified="2019-02-13" version="1">MRVSVIGGGTITDSQRTLSEAVGRELAARDHVVVCGGLGGTMAAVCRGAKRNGGTTIGILPGDSRGAANDDVDVAIATGLGHARNTLVPLNGDAVIALAGSAGTLSEIGFAAVYGRPIVSLGSREIDGLDIEVVETPAEAVEAVEAAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXW6</accession>
    <name>A0A3N6LXW6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_14775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86921">
        <property type="protein sequence ID" value="RQG86921"/>
        <property type="gene ID" value="EA462_14775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="165"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="7">
        <location>
            <begin position="237"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="736"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="805"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG86921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="868" mass="92256" checksum="BC87F1F1CE4A0F59" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYP8</accession>
    <name>A0A3N6LYP8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87793">
        <property type="protein sequence ID" value="RQG87793"/>
        <property type="gene ID" value="EA462_13045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="109"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="632" mass="72607" checksum="6E8A06848B866B86" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYS8</accession>
    <name>A0A3N6LYS8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86902">
        <property type="protein sequence ID" value="RQG86902"/>
        <property type="gene ID" value="EA462_14680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="278" mass="28955" checksum="D019D7FFE1909BA5" modified="2019-02-13" version="1">MPAPLVSPSDRSATLRTAALGSVSLPAIASIYFVATGYGLEGVVPPALLGVLLVGLGAILGGAFAAGYPASVGLSLVALVVLGPLWFVPIERPLSAPSADVATGPVLAVTILAVYLLAAEYGVRNRKRVFEWFTTRTLGVGLIGGGIHAVATIWMSAFVRQESIELGAVTLVSAVTVLYGAGGLVALGAVASIALYRLRLVTPVVTLAALFSWTFYSTWESLETVRETGADPGISPRADTIYVVLWMVTLVAILVVGALEYSLRSVVDERGDSDRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ91</accession>
    <name>A0A3N6LZ91_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-terminal binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88053">
        <property type="protein sequence ID" value="RQG88053"/>
        <property type="gene ID" value="EA462_14480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="33"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="117"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="329" mass="35673" checksum="60B6E78F0B648138" modified="2019-02-13" version="1">MSRTVRIVHLDPDWFGDVEQERRAFEREFDAVRVDAVDVPADASAGEIAREVGEADALLTHYTDVSGPLMDATGCSVVSRYATGIDGIDVEAATERGVKIANVPTYCDREVGEHVATLAMACLRGLPQYTSSTADGEWDWSAVDPVRSFSELSFGFLAFGNKARAAADIATAVGFECLAADPFLDDETIERAGVEPVEFDELIERCDVLSVNAPLTDETREIIDEDVLERMPDSSVLINTSRGELVDESALLDALEDGPLLSAGLDVLANEPPAETNPLLGRSDVFVTPHAAWYSERSVDELIEKGSEAVIAAYEEHQHEGIVNPETLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZQ6</accession>
    <name>A0A3N6LZQ6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">pyrG</name>
        <name evidence="13" type="ORF">EA462_10255</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88780">
        <property type="protein sequence ID" value="RQG88780"/>
        <property type="gene ID" value="EA462_10255"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="12">
        <location>
            <begin position="16"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="11">
        <location>
            <begin position="313"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="198"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG88780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="562" mass="62578" checksum="4762D6B5750C8C14" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0S8</accession>
    <name>A0A3N6M0S8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalt-precorrin 5A hydrolase</fullName>
            <ecNumber evidence="4">3.7.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cbiG</name>
        <name evidence="4" type="ORF">EA462_12870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.12" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89250">
        <property type="protein sequence ID" value="RQG89250"/>
        <property type="gene ID" value="EA462_12870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043779">
        <property type="term" value="F:cobalt-precorrin-5A acetaldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021744">
        <property type="entry name" value="CbiG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038029">
        <property type="entry name" value="GbiG_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11760">
        <property type="entry name" value="CbiG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159672">
        <property type="entry name" value="SSF159672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiG_N" evidence="3">
        <location>
            <begin position="67"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_C" evidence="2">
        <location>
            <begin position="211"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="328" mass="34911" checksum="5BDD02CD6896751A" modified="2019-02-13" version="1">MSTDDANDDSRSDADGGHCSTADSDGEVATEIAIIAFERKRGTAEEITAELDDRYETIDIIEYHGDVFEEHWGEYDCFIGLMASGIAMRKTAHLLEDKWEDPAICVVDEELTWAIPITGGHHGANQVARDLATMGAVPAMTTASEAAGKQGVESRAKAMDAHVVNGDSTVKTNLAVLDDTLGPVARLDGPRAVLVGNDVTVLKRNSDDGCVIGTGSVSGASTESFIAAWETALDRTEYDVGAVEFVATATRKEDEEGLLAAVEELDLGLVVFDRETLLEHEGPTPSKSKELIGWPGVSEASAIAGSAERELVLEKIGYENEVTVAIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1C8</accession>
    <name>A0A3N6M1C8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88891">
        <property type="protein sequence ID" value="RQG88891"/>
        <property type="gene ID" value="EA462_10870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="119" mass="13768" checksum="4FE096A371532E2D" modified="2019-02-13" version="1">MAANPIDGQILLLTAAKASVPPVRLPDIVEVGQAHLWSNRERYRREYERVHRGDELEAFLVPDDHWDGLGTELDLDDRERSAVRRAHQEQFRRLGRRTDQEEAFETALEIRDAVLIAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3K2</accession>
    <name>A0A3N6M3K2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_07110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89781">
        <property type="protein sequence ID" value="RQG89781"/>
        <property type="gene ID" value="EA462_07110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="57"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="5">
        <location>
            <begin position="312"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="69"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="421" mass="47378" checksum="22ABBF8B44B56871" modified="2019-02-13" version="1">MSANDDRDPLFRYDDPVFADERLLEITHLPGPDRIVGRDEQMQRVADALNPAIFGSEPNHLFIFGKTGTGKSLISRSVTKRVISEAERDDVTVKYAFIDCGEQNTEASIIKTIAQIVNDSTESGVSVPDRGLGTGDYYKRLWQAIDRCTDVTIVILDEIDMLEDDEVLRKLSRAGENRRISDSSIGIIGISNKIDFPDHLSERVKSSLSRDELVFSPYDANQLVEILEKRRDAFHDGVLSDDVIPLTAALAAQEHGDARKAIDILRNAGRIAKKQANTRVTAEHVRDAKEKTEADRFNELIEGSPQQAKAILYSLTLLTENSTQKEFPTKIIYNQYKEIAGRLDFDVLSERRVQEILQEQNFLNVIQSEREGRGRGRGAHAKHRLLENPSIVKKVLLRDSRLAPLENADSSTRSPETNRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3N9</accession>
    <name>A0A3N6M3N9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ketoacid dehydrogenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86737">
        <property type="protein sequence ID" value="RQG86737"/>
        <property type="gene ID" value="EA462_16510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="11"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="330" mass="35574" checksum="35BD3EC84C64351C" modified="2019-02-13" version="1">MSATAGESEEFAVRDVINRTLGEEMERDDRVYIQGIDVSGRGGTSNILKGLDDRFGTDRVRNTPISEVSMVGSALGAAATGMRPVVEVMYCGFLGVAGDQLLNQVAKMRYMFGGELDLPMVIRTKNVMGANAAAQHSQALHHWLAAIPGLKVVCTSTPADTKGLLKAAVRSDDPVMVFEHGGVYNRKAPVPTEDYQYEIGKAAIERRGEDVTVVATQNQLWNALEAAERLASDGISVEVVNPRTISPLDTETIVESARKTGRCVVVDDTPLSYGTQSQLSAVISEGAFWDLDLPVKRLGVDNVPIPFSPTLEDEIIPGTDEIVDEILDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M449</accession>
    <name>A0A3N6M449_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90001">
        <property type="protein sequence ID" value="RQG90001"/>
        <property type="gene ID" value="EA462_08315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="187"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="241" mass="26165" checksum="3DE43433A7EB917D" modified="2019-02-13" version="1">MTVTEKNRAGCDGCGRTVPLEKLSTVTMPNGDAVACCPHCEPHARRAAESVSTLDQRRNSCDGCESVFLESELEEIPLADGTVVSCCRSCAKTSSDGNATATAEDDANRSGDDGRTDDRGQGEIVEEPTDELGDEQSYRCTQCTELIEVEPFRITTVDGRTERFCPSCKERAKADGIIASVAMRKTKARDVLGVEKGASPDEIQTAYRGQVKRAHPDRPTGSLSAFELVTDAYERLRRDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4N8</accession>
    <name>A0A3N6M4N8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87127">
        <property type="protein sequence ID" value="RQG87127"/>
        <property type="gene ID" value="EA462_15175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="365" mass="38075" checksum="C6FCC16318EF899E" modified="2019-02-13" version="1">MALQSRGALLSSFEGTFGVSESLLGLVAPAGTVGFVVAILAVGMLAGRLDVRHVLVFGAVAMAISLFAISVAPAYSLFLFALLVQGSAAGVFRAMDRPLLSHLYPDRRGRIFVLYALAWAVGAVVGPVLASAVLLVADWRAVYVILAVSIVPVVVLVLSLEVPSWNEQPLERDAIGPLLSSSGVRTTLLALALAGGIEGTVFTWLPYYAGTFLDRTTANLALSAFLLAYIPGRYAYAKLVDSISYLRLSLVTTGLSIPAFAIALGWPSVGMLVAVFCAGAFISSLFPLLSAYGVDIVPEYSGPMSALTTGATYAGTAFVPVVVGIAAELTSIRIAMWIPIGLTVVLFGLIWSMPARAEVSEAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5P7</accession>
    <name>A0A3N6M5P7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl4</name>
        <name evidence="6" type="ORF">EA462_05030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91340">
        <property type="protein sequence ID" value="RQG91340"/>
        <property type="gene ID" value="EA462_05030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_A">
        <property type="entry name" value="Ribosomal_L4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_L4/L1e_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_L4_euk/arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019970">
        <property type="entry name" value="Ribosomall_L4-archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="PTHR19431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03672">
        <property type="entry name" value="rpl4p_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="250" mass="26779" checksum="BE2D4212B256416C" modified="2019-02-13" version="1">MEATVRDLDGGDAGSVTLPAVFETQYRPDLIARAVRVAQANRTQDYGADEFAGKRTPAESLGSGRGMAHVPRQDGRARRVPQAVKGRKAHPPKAEKDWTESINTKERKLAIRSAIAATADAEVVAERGHEFDDDAEIPVVVADEFEDLTKTNEVVSFLEAAGLEADIERADEGRSVRSGQGKARGRKYKTPTSILFVTASETGPSRAARNLAGADVATAAEVNAEDLAPGTQPGRLTVWTESALEEVADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6D5</accession>
    <name>A0A3N6M6D5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91630">
        <property type="protein sequence ID" value="RQG91630"/>
        <property type="gene ID" value="EA462_06685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07726">
        <property type="entry name" value="ST1585-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037482">
        <property type="entry name" value="ST1585_MBL-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="30"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="306" mass="32934" checksum="D0210472D62BFBA0" modified="2019-02-13" version="1">MGIGDCYDVTAGDWADLSYVDTGMFGTSEYGAVYILDGERPAVIESGIGTNHERILEALAEVGIDREQLAAIAVTHIHLDHAGGAGFLAEACPNADVYVPDVGASHLVDPAKLVAGTKAAVGEQWEWYVEPKPVPEDRIVGVEDGDAIDLGDHELRVHEAPGHAFHQVVFEAPERGTVFTGDAAGIWVPAREEIVETSPPSDFDLEECLADVEMLQSIDPDVLCYTHFGPRAVGDDASHALEQYSTVLEEWVAAVDAARADLGDDELVIEYFADSDELADVWGERKASAEAVMNVRGALGYLDDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6D6</accession>
    <name>A0A3N6M6D6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88856">
        <property type="protein sequence ID" value="RQG88856"/>
        <property type="gene ID" value="EA462_10675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="459" mass="52174" checksum="1DC33FD695A5EF8F" modified="2019-02-13" version="1">MAKNNEERQQRLDGSPVDDEDEPGEELNDVGETYSWHQTKGGYNRHILSSLMQKSVRRNQPEIAEWVAYEMCRSGYSDNVWKRLNLYILEDLAAGVQGATEIRVLERIADQSDDRDVILCAMRAARIAAKARPSREATYLNDGFDKACKDRVRAQQDGEHETLYDLPVNPGTLTDEDELGPPIEEADTDKQLTFGDGKREDDSDDEVPTNDFGEPLRVEETHHSFDQRLLRERLRRAISDDDEEVASFCSWELARSGFGEKFWSEITNLAIEHASASAITVVETYERMARERYEDLSCWESKLAAIYAALSVVRSERPAVNDRIAEFDRIASERAEAMMSGEEPEVTFPAEPDELVIGEKYDVVVDKHCYAGKGAGRGWDHFKIHGGRVAEPGEPPLAMKWRRISMEYDHPRFDYRVPEVAFTEAEIEHSLKPVDPEDAWDEPVDLRNKTLGEIGGAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6G7</accession>
    <name>A0A3N6M6G7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease HII</fullName>
            <shortName evidence="10">RNase HII</shortName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rnhB</name>
        <name evidence="13" type="ORF">EA462_06910</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10 11">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 10 11">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91670">
        <property type="protein sequence ID" value="RQG91670"/>
        <property type="gene ID" value="EA462_06910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_A">
        <property type="entry name" value="RNase_HII_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020787">
        <property type="entry name" value="RNase_HII_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00729">
        <property type="entry name" value="TIGR00729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="12">
        <location>
            <begin position="4"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG91670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="226" mass="24050" checksum="87919FFE8EA9ECAD" modified="2019-02-13" version="1">MPFGVDEAGKGPALGSMFAAAVSLEDPEYLPEGIADSKRLTPERREELAATLRDDDRIAVGVAEITPARIDHPETDMNSLAVDAHAGAIDDAFTDCDLDPSEDSSIGGLCDACDTDADRFARRVTEACSSETDRRLDLEARHGADEDSPIVGAASVIAKVERDAHVDAIAAEHGDVGSGYPSDPTTREFLETYVDDHGDLPPFARESWSTCADVLAAAEQTGLEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6I1</accession>
    <name>A0A3N6M6I1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88916">
        <property type="protein sequence ID" value="RQG88916"/>
        <property type="gene ID" value="EA462_11010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="201" mass="23004" checksum="A07BA6723B1DDDAF" modified="2019-02-13" version="1">MGLYERYLARRIRNHEADPPNHVALIITERDLLEDGAYETLVAFFSWALEYAGRVTVYVSVLDAEAVPTLRRDLEGIDAPEVVAVRGPDDRTRADAPIQIGIGLGGKHEFTSAVRTLAERVDAGEIEPDEIDDGDVEDHLVFPAEPDLVIKTGAERLSDFMIWQSVYSELYFTDVNWRDFRKRDFLRAVREYCNRSRRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M737</accession>
    <name>A0A3N6M737_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91151">
        <property type="protein sequence ID" value="RQG91151"/>
        <property type="gene ID" value="EA462_03915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="52"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="205" mass="22255" checksum="3011A448AF1DA256" modified="2019-02-13" version="1">MDLGERRGLETDVYQPAEDSQLLAEAACEGIDRDRDCERGRTTGRPDDRRLVLEVGTGSGYVASRVASETSARVIASDLNPHAVRQARRDGLEAVRADLVSAFADDVFDAVLFNPPYLPTEPDTEWDDWMERALSGGEDGRAVIDPFLEDVGRVLAPAGVVYLLVSSLTGVDGVVERAGREGFSAVALAEESFPFETLSILKLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8F9</accession>
    <name>A0A3N6M8F9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1611 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91651">
        <property type="protein sequence ID" value="RQG91651"/>
        <property type="gene ID" value="EA462_06800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035402">
        <property type="entry name" value="DUF1611-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035086">
        <property type="entry name" value="DUF1611_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011669">
        <property type="entry name" value="UCP026760"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40690">
        <property type="entry name" value="PTHR40690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07755">
        <property type="entry name" value="DUF1611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17396">
        <property type="entry name" value="DUF1611_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026760">
        <property type="entry name" value="UCP026760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1611_N" evidence="2">
        <location>
            <begin position="36"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1611" evidence="1">
        <location>
            <begin position="135"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="344" mass="36997" checksum="ACAE39498C35408D" modified="2019-02-13" version="1">MRVAILAHELFPNEAKTALGVLRYADDEIVAVLDRDNPNRRVNEFVPDVQDAPIVTGMDDLEDDEVDALLIGVAPIGGGFEESWREDVRKALERGHDVISGLHYFLSEDDEFDRLAEANDCELRDVRKPPEDLSVSDGIASDVDAEVILTVGTDCGVGKMTATMELVADAREAGYDAAVVPTGQTGIMIEGWGMPVDRVVSDFTAGAVEEMILEAGTDHDYLFVEGQGSIVHPAYSGVTCGILHGAMADRLVLCHDAGREAIHGYESFSLPPLSRYIDLYEDLAAPVSESRVVAGALNTSGLEDSVAREAVNEYEAAIDAPATDVIRFGTDGVLETLLESGSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8K7</accession>
    <name>A0A3N6M8K7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91711">
        <property type="protein sequence ID" value="RQG91711"/>
        <property type="gene ID" value="EA462_05255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="103" mass="11290" checksum="FD7C386D41C9022B" modified="2019-02-13" version="1">MKTAKSADGTSIAYERTGSGPPVVLVHGTTADHSRWGPVRSGLEAHYTVYTFDRRGRGESGDAPSYRLEREFEDAVAVVESIEEPVTLVGLVFVALERVRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8S3</accession>
    <name>A0A3N6M8S3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89866">
        <property type="protein sequence ID" value="RQG89866"/>
        <property type="gene ID" value="EA462_07575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="232" mass="26282" checksum="B56076DB569758FC" modified="2019-02-13" version="1">MAYARDESDGYREIDRFDDGVGWIAHREEFGQRASHAVRGEEGIWLVDPLRAPGVGDLIAALEDDVVGVTVCSCWHARDADWFAREYDVPVSVPEWMGRIEERTDAPVRRYDDRPAPTIRVQRCEPVPMWSEAILFWESHETLYVPDSMGTLDPFVVGNERIGLELFRRLAPPRSLRRLEPDRILVGHGDGVFEDATRALENALAGGRRRFPRALFENGPGTVRSLVGAIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8T6</accession>
    <name>A0A3N6M8T6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92660">
        <property type="protein sequence ID" value="RQG92660"/>
        <property type="gene ID" value="EA462_00015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="651" mass="71369" checksum="59E7526F142C4A6A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8W2</accession>
    <name>A0A3N6M8W2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92690">
        <property type="protein sequence ID" value="RQG92690"/>
        <property type="gene ID" value="EA462_00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="63" mass="6678" checksum="FE86EDAD914FF5FE" modified="2019-02-13" version="1">MSVRGLLYRVPGYARCTAVLVRPASVAKLTSADRLISLESDAERTAILLGSTTRSLGAIVCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M968</accession>
    <name>A0A3N6M968_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Type II methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_00915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92820">
        <property type="protein sequence ID" value="RQG92820"/>
        <property type="gene ID" value="EA462_00915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="8">
        <location>
            <begin position="130"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG92820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="454" mass="50607" checksum="ADCC0DE4A93027EA" modified="2019-02-13" version="1">MSDDSAGLNHELLGQQGVSGEIEDVLGRIVSCLGKEVTLGQEQDSANDQLPSELNISPTEAQKLYESLKAHFQAQNTGPPFSDVKEVQGDIPEMEDRPIDVERANACKIHPSDSGREDDGHKLELEGNSVNLIVTSPPYWQLRDYGVENQLGQEDTPEKYVDDLVDALNTWEEFLHPKGSVFLNIGDKYHEKSQVGIPGMFAERARQDGWTVRNHIIWAKKNGLPSPAKDRLVPRHEHIFHLVRDDDYYYDLFGYSKVFGNGANPGDVWNMSHDRNTGGHLAPFPSELVLRAVTLACPPAVCPKCGEPHSREIERPLLNLNQDRPQAKRALKKFKESDLTEEHLKAIRAVGISDAGKAKEIQEETGTNDDEIQELADEAKEVLGGYFREFTFPLPTTVGWSGCECEVDPQPGMVFDPFSGSGTTINTAYSLGYQAWGTDLDRSNFEPKLDNFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9S2</accession>
    <name>A0A3N6M9S2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93050">
        <property type="protein sequence ID" value="RQG93050"/>
        <property type="gene ID" value="EA462_02225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="98" mass="11624" checksum="51417DE7BE4C09E2" modified="2019-02-13" version="1">MISCLLPLFMSGKDIYWDFTNIQNTRYCETMKTISPVNLTTFTDSNKRFQTISILKLGLSLIIFRNIMFSSIIRQVTTFFDRIIKELIEMQTFFFELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBS1</accession>
    <name>A0A3N6MBS1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle 54 kDa protein</fullName>
            <shortName evidence="8">SRP54</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">srp54</name>
        <name evidence="12" type="ORF">EA462_01485</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92921">
        <property type="protein sequence ID" value="RQG92921"/>
        <property type="gene ID" value="EA462_01485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54_N" evidence="11">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="96"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="10">
        <location>
            <begin position="97"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="184"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG92921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="461" mass="50347" checksum="405C7E024979D77B" modified="2019-02-13" version="1">MVLDDLGSSLRDTLDKLRGKSRLSEEDVEEIVKEIQRSLLSADVDVSLVMELSDSIKERALEEEPPAGTPARDFVLRIVYEELVGLIGESTELPLEEQTILLAGLQGSGKTTSAAKMAWWFSTKGLRPAVIQTDTFRPGAYDQAKEMASRAEVDFYGNPDNDDPVDIAREGLEETSEADVHIVDTAGRHALEDDLIDEIEEIEAVADPDTSLLVLDAAIGQGAKDQAKQFDESVGIDGVVITKLDGTAKGGGALTAVDQTDSSIAFLGTGEEVQDVERFEPDGFISRLLGMGDLGQLAERVERAMAQTDIEEDDWDPEDMLKGNFTLNDMQKQMEAMNNMGPLDQVMDMIPGFGGGIKDQLPDDAMDVTQDRMQTFSVVMDSMTDAEKEYPKAVGASQVERIARGSGTSEDDVRELLQQYKMMEKTIKQFQGMGSDQEMQRMMKQMQQQGGGGGMGGMGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC54</accession>
    <name>A0A3N6MC54_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="8">PRA-PH</shortName>
            <ecNumber evidence="8">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">hisE</name>
        <name evidence="9" type="ORF">EA462_02370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PRA-PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93071">
        <property type="protein sequence ID" value="RQG93071"/>
        <property type="gene ID" value="EA462_02370"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG93071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="94" mass="10742" checksum="B7964A185E39511C" modified="2019-02-13" version="1">MQDILEELFDVIEDRKETLPEDSYTASLFTHEKGENAVLEKLGEESTELVLAAKDDDHDEIAYESADIVYHLLVLLSMKGMDIEDLEAELEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCS6</accession>
    <name>A0A3N6MCS6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_06245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91556">
        <property type="protein sequence ID" value="RQG91556"/>
        <property type="gene ID" value="EA462_06245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG_CoA_synt_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="HMG_CoA_synt_C" evidence="3">
        <location>
            <begin position="195"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="445" mass="49304" checksum="32EAC4233878AA9B" modified="2019-02-13" version="1">MTAVGIDAIEIWTGNLKLDLPGTFAPEKGEDPEKYTKGLGLNASSFPDSYEDIVTMGANASHRLMERKGLEPDGIGRIDVATESSFDNSKPVSTYVAGCLEGVFEGDFHHANKGERKFACIAGTQSLDDAYNWIRADRNRGRSALVIATDTALYARGDAGEATQGAGAVAMLISENPDLVELSTEQGYGSADETDFLKPNQQFPSVDGKRSVQVYLARMREALTDYESVAGDVHPDDIAFIPFHTPFPGMVRKAGLLGYRHITRDTTIEDDLADEIGRQPRREAFDDDEAFRDSVREYMDLLKGTDRYKAWYDATIDPTLTLSREVGNWYTGSVHIARVSALKNALEAGRDMAGETILVGSYGSGAQAEIHAETVQDGWTDEIEALNVDDQLADRYDLSWADYEEVHDVHNHEMDVDVEEFTTPDGEFVFDGWGRMGERKYRYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MQL3</accession>
    <name>A0A3N6MQL3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86109">
        <property type="protein sequence ID" value="RQG86109"/>
        <property type="gene ID" value="EA462_17300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="296" mass="31226" checksum="59CC42048F001F11" modified="2019-02-13" version="1">MTLESALQGITCPVVTPFDEDSKRVDEAAFGAIVEDLVANDIDGVFSCGTAGEFASLTADERRRVHELAVEHADGSVPVLAGAGATTVSETLEHIEAAAAVGADAAVVVPPYFHTANDPAGNRRFFETVADASPLPLLLYNIPLCTGRRIHLETVESVATHENVIGLKDSGGDLQYFLSVIRRTPDSFLVLQGFDTLVLPSIRMGGDGGVNTLSNVAPAQYAELYETADRRRAREVQDAVASLFESCAEYGFAPGTKTALASRGGIPSDTVRLPLVSVPEEGRATIATQVEAVLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MQR5</accession>
    <name>A0A3N6MQR5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Type II methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_16945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86159">
        <property type="protein sequence ID" value="RQG86159"/>
        <property type="gene ID" value="EA462_16945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG86159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="358" mass="40835" checksum="DF2020AF773BC557" modified="2019-02-13" version="1">METTHRVYVEDSRDLSNLDDDSVELVVTSPPYPMIEMWDDLFTDLDPAIGDALESGDDRAAFDAMHAQLEAVWDELERVLVDGGLACINVGDATRSIGGRFRVYPNHARILESFEARGFDPLPDVLWRKPTNSAAKFMGSGTLPPNAYVTLEHEYVLVFRNGGEKREFEPRADRRYEAAYFWEERNRWFSDVWTDVRGELQDLEFDGEGSDLRERSAAYPLEIPYRLICMYSTYGDTVLDPFWGTGTTSRAAICAGRNSVGYELEDAFLEVFDDRVDAVPELSRSIGRSRLDRHRSFVENRRDDGKSLGYEAVHYETPVVTKMERSIRLREATAIDERSDGYRVEHRPLSISLESPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MQY8</accession>
    <name>A0A3N6MQY8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86643">
        <property type="protein sequence ID" value="RQG86643"/>
        <property type="gene ID" value="EA462_15960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="128" mass="13378" checksum="A3F09DB9CF1585B3" modified="2019-02-13" version="1" fragment="single">DATDEQARASGRVVTMVDEATEISEETNAETETVAAAAEEQTATVSEVATGAQSLTEMADDLRNSLDAFDVTEEDDAGSDTALESDGDIETDDAETVLEYDDRDPSTTDGVDGEDSDGETADSESNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MQZ7</accession>
    <name>A0A3N6MQZ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AbrB/MazE/SpoVT family DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86653">
        <property type="protein sequence ID" value="RQG86653"/>
        <property type="gene ID" value="EA462_16025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="102" mass="11793" checksum="548C9C6A219332A6" modified="2019-02-13" version="1">MSSNTKPNDEERIVSVTEKGQATIPKRLREKHGIPAPGRVKFVENDDEEIVVRPVGSMREFRGLERESDDERPATAILREEREREKQRADETVERFSGKTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MR79</accession>
    <name>A0A3N6MR79_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Archaeal flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the archaeal flagellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86753">
        <property type="protein sequence ID" value="RQG86753"/>
        <property type="gene ID" value="EA462_16595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097589">
        <property type="term" value="C:archaeal-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35903">
        <property type="entry name" value="PTHR35903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Arch_flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0974">Archaeal flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="215" mass="22279" checksum="E85DCA197701E545" modified="2019-02-13" version="1">MFVDESTDRGQVGIGTLIVFIAMVLVAAIAAGVLINTAGFLQTQAEATGEESTDLVSERIDVVSEVGIVEDSEDPSNLSSINLTVTGAAGASDIDLNQTIIQAVGPNGQANLVLNESVDDGDPANATELNETFAVINESNQYVDSDSAVLGDENNEFTIILNPEATPFGDSDDPAVTFGQGDESSLAIVSPSGATTEVELRAPDLFTDEGEAVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSX7</accession>
    <name>A0A3N6MSX7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87875">
        <property type="protein sequence ID" value="RQG87875"/>
        <property type="gene ID" value="EA462_13510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="2">
        <location>
            <begin position="81"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="151" mass="16822" checksum="C52F0A2C2BC09EC7" modified="2019-02-13" version="1">MIVFPPATSSPGEQKTRSATIITRPSTEPSSTSPRLTSFSSESESTDRPIRHPYFRRFDRSRVLRRHSSNDVSRLLGGETITEVCVESTVRSAFDRNYRVTVLSDCTAFADLEARERSLDRIDAKFGSVVASTEVSPEEVFLSDGIVCRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MT98</accession>
    <name>A0A3N6MT98_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_14260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88015">
        <property type="protein sequence ID" value="RQG88015"/>
        <property type="gene ID" value="EA462_14260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG88015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="505" mass="52833" checksum="F2B35581741387E0" modified="2019-02-13" version="1">MARDEMNDQFSTHVSALLDGANQTVVVGSLAVLAAVSGLLVLLPGPTGTGVSALEGFLLFEVGFVFGLALAISLVVLGIIAVGPWGRITLGGDDATPAYGNGTYFAMLFAIGIAAGIAFFGPGEAAYYMLDVPPGIDPGVDAHDRGVWGMSFTLTHWGIITSATSAVFAVPIGYYYYRDDAPFRVSSALYPLVRDRPMLAAIVDIFAISGLVFGLASSIMETTQNFLAGISFQWGVASPETGTVLFIAAVTLVYTLSAYTGLNRGIRRISVLSLGLFLVMGGATFVFGGASEIVGLSIGATAAQPSHLYALATSIQTEWVAIWHHYNTAIWFSISAGYGLFTARISYGRSLREIVAYAVVASGLANMVWFYVVGGGVVRQAISDGGETLSLIETEGFAVAAFPLLLEFPFGELFLFLFLGIGLLFIINSADSQTMSVAMMTSKNTVDPPGIIRAFWGTAIGLVAVMLILVGGADIVGSFAVFTGFALAILAVAALATTLVSMIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N156</accession>
    <name>A0A3N6N156_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91682">
        <property type="protein sequence ID" value="RQG91682"/>
        <property type="gene ID" value="EA462_03555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="69" mass="7814" checksum="AE47F088DD622E34" modified="2019-02-13" version="1">MRILVFPLVVLGVRVERPFIELFQLTTPLSDLVLLVAVITSLLYVLVRGGTLLIDHYHRTVRPRSGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N473</accession>
    <name>A0A3N6N473_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA ligase</fullName>
            <ecNumber evidence="10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">ligA</name>
        <name evidence="13" type="ORF">EA462_01790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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</entry>
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                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
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                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="199" mass="22072" checksum="733AE539BF683F9D" modified="2019-02-13" version="1">MKLRQNVRHFASRKALETPVVRSVATSGLVRLHTKVFLKKADPAHADEREDHLDGLFEATVDAYLRALQDGYSEAEAREITHIQANFDFYNHGWTEMMEFPADELETHYDRYAEFFGRWDITIDDPLGQFTPPSGVPNAPSTPGKLEDPDHPHAEGGFADDVYVENEDGELVVGGQDDPDAVDVSKAVGVDADTAGTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVN9</accession>
    <name>A0A3N6NVN9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
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    <gene>
        <name evidence="6" type="ORF">EA462_13755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87922">
        <property type="protein sequence ID" value="RQG87922"/>
        <property type="gene ID" value="EA462_13755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="271" mass="29932" checksum="F90EBA0FBFB63D08" modified="2019-02-13" version="1">MATADESSLRQQLTLSMDDRNHQIILQAGFGVFLLALYSLFAYLGYPSDRIPSVPMIADALYVQVAEEGLLEALWDALYAIFIGFFMATLVGIPMGILMGVNRTIEELLDPYVNAIYVVPYAAIVPALIVWFGTGIRIRVAICFLFAFFPIVINSFEGARTTPAGLLEVAESFNASRLYTLKNVVLPYEIPYILAGLRMGIGRAVRGLVLVEIIVAVTGLGGLIQQWSASFRLEGVISVVLVLMLLGVTLPWLMGKIYDRLIWWDVDRAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVS8</accession>
    <name>A0A3N6NVS8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_14130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87992">
        <property type="protein sequence ID" value="RQG87992"/>
        <property type="gene ID" value="EA462_14130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015417">
        <property type="term" value="F:ABC-type polyamine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG87992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="42514" checksum="E6C010BDFDCEFB01" modified="2019-02-13" version="1">MASASRQSQGELDESESDVILRLDGVTKNFGSVTAVDDVSFSVRKGEFFSIVGPSGCGKTTTLRMIAGFEQPSDGRILLSSEDVSRVPPYDRDLGMVFQGYALFPHKTVGENVGFGLKMQGEDPEERQEHVADILDLVDLAGTQDRYPKELSGGQQQRVALARALVIEPSVLLLDEPLSNLDRKLREEMRFELKRIQEELGITTIYVTHDQEEAMSMSDRVLVLNGGESEQVAPPYDIYHRPRNQFVAEFIGDVNTFPGTVEAVTEDDYHVDLETEATGTVEVKRTVARNEFEVGDDVLLNVRPEDFEIVETGHGEDRFTGQVITSTFLGKRTNLLVDVGDQQLLVEASGRIEQDGSKAEDAITISWKRNQCILTDVDSDHVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWI1</accession>
    <name>A0A3N6NWI1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88909">
        <property type="protein sequence ID" value="RQG88909"/>
        <property type="gene ID" value="EA462_10975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="227" mass="24691" checksum="5818EA1AD8D33053" modified="2019-02-13" version="1">MSSPALDITMFRDEDVDDDTFSVAVDAIGNLADQLGTDSSATSHGTRDGPDHNDYSDYLDELEYRNIPGVHADFVPDGNQGLLLYKRDLSSEVPAGASRSFFRSDDSCYAVANAYLMESSIGSESAFRNIVKHELLHSLMNGDDNCPGTHVSRSDDHSCGHVEESWFQATITPMATGYALSLPGVDTNHPPSEFCGYEGDPSGSPNWTPDLSGCTESEATRWLSDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWX7</accession>
    <name>A0A3N6NWX7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89099">
        <property type="protein sequence ID" value="RQG89099"/>
        <property type="gene ID" value="EA462_12055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="152" mass="17215" checksum="7EE0B3956F7DD884" modified="2019-02-13" version="1">MTDVTYVQKACAYITRSTGELLVFEGPGHDGLQIPKGTLETDESPKEALFREVLEESGLGTLNATQHLSTDVWTRRRSPPKRYVRHFFHSTVHEPRDRWTHRVTDGGDEHGSEFELYWVRPSTSRTFALDLDDYVQLLPTAEPPGDLATASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX28</accession>
    <name>A0A3N6NX28_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89179">
        <property type="protein sequence ID" value="RQG89179"/>
        <property type="gene ID" value="EA462_12495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="240" mass="26142" checksum="16E3A0E26FB03ECC" modified="2019-02-13" version="1">MCFSPDDASHDGDHPIAPLLERSRIDSDAELEIAVSVSGTADIEENELDVFLGTDRVDPGGRIELGVFVSGTGRVTENDLSVFYDGDELIDLEDPGVVRRNSGPGSAESTEATADAGIEAVRAGQTGRRIDGRRSTLFRRDSSDAGGALRWKPLDGNRTGEPAYLLEINTRKATPPGEYVIPVVFTYRSDSGIRQVERVPRVRVTTRRERLEPWLARGLMAAVVLGAFVAFAAWGPLLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX39</accession>
    <name>A0A3N6NX39_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoglycolate phosphatase</fullName>
            <shortName evidence="2">PGP</shortName>
            <shortName evidence="2">PGPase</shortName>
            <ecNumber evidence="2">3.1.3.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the dephosphorylation of 2-phosphoglycolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-phosphoglycolate + H2O = glycolate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="EC" id="3.1.3.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal SPP-like hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.18" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89209">
        <property type="protein sequence ID" value="RQG89209"/>
        <property type="gene ID" value="EA462_12650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01419">
        <property type="entry name" value="GPH_hydrolase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006382">
        <property type="entry name" value="PGPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="228" mass="24481" checksum="D3A9A3FE2EE00549" modified="2019-02-13" version="1">MSSDPPIVLDIDGTLTRPDRWGLDPRVLDPIREWDSPVVIATGKAFPYPVALCHFTGIPELVVAENGGVVYTGENVFVTADRDAARAVTDEYRAAGYSLGWPADDTVNRWRESEVAVNRDQPLEPLRAIAAEYGLEVVDTGYAYHVKEPEPNKGDGVSRLAAHVGFELGDAVAVGDSINDVSTFEVVGSSFAVSNADEDARAGADEVVEQSHADGTLAVLERVRGTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYE9</accession>
    <name>A0A3N6NYE9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF354 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89849">
        <property type="protein sequence ID" value="RQG89849"/>
        <property type="gene ID" value="EA462_07480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007152">
        <property type="entry name" value="DUF354"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39662">
        <property type="entry name" value="PTHR39662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04007">
        <property type="entry name" value="DUF354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="372" mass="41228" checksum="43A0BEC8864B707C" modified="2019-02-13" version="1">MRYLFFTNTPAHVHLYKHAVRTLREGGHDVLVLARDYTCTVDLLEWYDLPYEIYGRCGTTKGSLLSRLPAHYARAIRLALRFDPDLVVGMGGYAAHTGAVIVTPTVLFIDSEPASFDHTISTPFARAVLTPNTFQKDLGERHYVFSGFKECAYLHPDVYEPNPSIRDRLEIGRDESYVILRLNAFGSQHDVGKAGISGDDRHRIVDRLSDDATVFVSDEGGDADLEGLPARPFDLHPALMHDALSEATLLVADTQTMVTEAALLGTPAIRSNSFVGDDDMGNFVELENHGLIHNVTSAQEIIERSSAILESETVDEVWQRRRDEFLSDRENLTDVIVDVATAHGRVDELESVRQFDGDVASEPSRSVGIGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYW3</accession>
    <name>A0A3N6NYW3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90069">
        <property type="protein sequence ID" value="RQG90069"/>
        <property type="gene ID" value="EA462_08700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="126" mass="13393" checksum="F19C79370CF7AF57" modified="2019-02-13" version="1">MPRIISTDDAPAAVGAYSQGTTNGQLVFTAGQIPATPDGEILADEPIGTQTERSLENVEAVLEAEGVGLENVLKVTVFLDDIDDFEEMNDVYSEYFESDPPARSALEVANLPKGVGIEIEAIAAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ81</accession>
    <name>A0A3N6NZ81_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF420 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90219">
        <property type="protein sequence ID" value="RQG90219"/>
        <property type="gene ID" value="EA462_09550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007352">
        <property type="entry name" value="DUF420"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37692">
        <property type="entry name" value="PTHR37692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04238">
        <property type="entry name" value="DUF420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="200" mass="22075" checksum="EB0E98A9B7F9C2A3" modified="2019-02-13" version="1">METAGARRRLRERPLGVTIALTIVGYALVIGTFLLELPIYPDLTNPQITLFTHAIAVINSLTLALLVAGWYWIRTDQVDRHRLAMTSAFALILLFLVVYLIRVGGGGEKLFVGPDSVYYAYLVMLAIHIVLSIVAVPVVLYALILGITHTPNELRRTPHARIGRVAAGSWILSLALGIVTYLLLNHVYEYEFSAVVAPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZJ6</accession>
    <name>A0A3N6NZJ6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Glutamine synthetase</fullName>
            <ecNumber evidence="2 6">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glnA</name>
        <name evidence="8" type="ORF">EA462_15155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2 6"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86986">
        <property type="protein sequence ID" value="RQG86986"/>
        <property type="gene ID" value="EA462_15155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="7">
        <location>
            <begin position="111"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="3">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="451" mass="50530" checksum="04622AFB5AADA900" modified="2019-02-13" version="1">MTSGNLTEAEQAVLDEIEEHDVDFLRLQFTDILGTVKNVSVPARQAEKAFREGIYFDGSSIEGFVRIQESDMRLVPDPDTFAILPWRQKEDSAAGRMICDVYNTSTGEPFEGDPRRVLKNALDRADEMGYTVNAAPEPEFFLFEEDEDGRATTKTGDHGGYFDLAPKDLASDVRRDIIYGLEEMGFEIEASHHEVARGQHEINFEYDNALTTADNVATFRTVVRAIAAQHDLHATFMPKPIPKINGSGMHTHLSLFTEDGENAFHDENDEFDLSDTAHSFLAGILEHAPAITAVADPTVNSYKRLVPGYEAPVYVAWSDRNRSALIRKPAARVPAASRIEARFPDPSCNPYLALAALIHAGLEGIDQDLECPDPVRENIYEFDEAKREEYGIETLPSNLGEAVDALEEDEVIYEALGEHVAPKFVEAKSKEFEEYLIDVSEWELDRYLETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0K4</accession>
    <name>A0A3N6P0K4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88028">
        <property type="protein sequence ID" value="RQG88028"/>
        <property type="gene ID" value="EA462_14335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="112" mass="12882" checksum="5AABC225DF4FEB00" modified="2019-02-13" version="1">MTECQIVDRDGVVRCVCEADEILRLLANGRRRQIIAFLESHEDDWARIETLIDDISTTTTMTDDDWETEFHHVHAPMLEASGLIEYDGQNGTIRYYHCELVSTVVDVVNARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1J5</accession>
    <name>A0A3N6P1J5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91379">
        <property type="protein sequence ID" value="RQG91379"/>
        <property type="gene ID" value="EA462_05235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="650" mass="74587" checksum="9F234B9F213D54FB" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P276</accession>
    <name>A0A3N6P276_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_12845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89245">
        <property type="protein sequence ID" value="RQG89245"/>
        <property type="gene ID" value="EA462_12845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="408" mass="44809" checksum="39A6DEA894D20C13" modified="2019-02-13" version="1">MTTSHDTSPTTAFDDEAILLIGHGSRRAKSNEQVRKLAADLETRLEIPVDAAFLELAEPAIDEAVSELAMVTSELTVVHCSLFAASHVKNDVPLAIEQARATHDLAINNGSHLGIHPAIIDLLDDRAGAVERELGVRRDRDDVAVVVCSRGSSDPDANGDVHKLSRLLYEGREFDRVEASFIGVTEPTLEETLHGLSKHRPDAIVVLPYMLGDGVLTRRVRDWTAEFDDDYPYVDALAGEALGTDSRLLDVFADRWQEARTGSVEMSCDTCKYKVDLAGYEEDVGGARAMLRALTHQESHADRTDLDDEPHDHDAPKNHVAVCTNRTCAEMGSPRVLERLRQQARDSDHCDARITRSSCLGRCGDGPVIAVYPDGVWYGDVGTTDAKRIVTDHLDRGRIVSELVDQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4M4</accession>
    <name>A0A3N6P4M4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PGF-CTERM sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90355">
        <property type="protein sequence ID" value="RQG90355"/>
        <property type="gene ID" value="EA462_07695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="328" mass="34654" checksum="9CF89D25934E3FEF" modified="2019-02-13" version="1">MSESRRSVLTGALVLLLVGSVGVSAVAAGGVTTAAPTPASHSTVQESSDTVSEEAYTEPVPDEGDPYFEAGADDGSWISYVNPRDEYRTPYLGDGSGKLCVTLVNEAGESIVGETVPNTTVTVATGEELEWHSHADPMTVEYPLTQHYDRPLDADQFGTESNLPQGDGYLDSHCIEMHGLTENATVEYGPAEIDGEHADRIELVGYVQQAHEAWDTDVDPIADARPYEEAGGWTYHPDGSHGQAVVVLQLEGGGANGDTSDDGISLGHDGIDSSSDFESDDAAETGQESETERERNESANDGIDPTPGFGVLAVVVSLLIVALTKRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4N0</accession>
    <name>A0A3N6P4N0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Electron transfer flavoprotein subunit alpha/FixB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_08990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90375">
        <property type="protein sequence ID" value="RQG90375"/>
        <property type="gene ID" value="EA462_08990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="6">
        <location>
            <begin position="120"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="511" mass="56472" checksum="544626E4F5C3BDD9" modified="2019-02-13" version="1">MEPGEHTVDELNERLETVDDEEVLETVLEAEQSGQDRKTAREAIRSRLEAVDAPGNEENGASGGDEDDESAGEEEPDAGDDESAGEEESDDGGEEDDGLTHPTRDKRHVRALADGDYEDMWVFCETQGGELLEVSREMLGKARRLMDQFSEDYGDEERVVAYLMGDDCEGLAEECIAYGADVALYHDDTRLERFLHKPYTEISAHMARGEGTAESTDWRDYDKPRYILFPATNNGRDLSAKVQAELDSGLASDCSDLFIEENEVSNPVKTGEPGVKKTFEKVLHMKRPDFSGFEYSTILCLDNPGREFHPQGASIIPGSFDPIERDDDREGDVIEHDMELDEDWFRVEITEYDQLEAGVDLTGHEVVVCLGRGIADDPTVGMELGLDLVDAFEDAELAITRGIVTSSYQFEGHVERYSKEERQIGETGQVVAPQLYIAAGVSGAVQHKVGMDQSDTIVAINTDTDARIRDFSDYFIEGDLFEVLPRLTDAVEAGETTLEAVADGHGGDGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4Q3</accession>
    <name>A0A3N6P4Q3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92969">
        <property type="protein sequence ID" value="RQG92969"/>
        <property type="gene ID" value="EA462_01775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="89" mass="10350" checksum="C9D94AB8A8402936" modified="2019-02-13" version="1">MDDSSERCWLVEREFGDRNVVTIVYATPDGTRYHQRERSEAALRTGSPVTAAVDVAEDDLEEVRDERTRERYVTEVERTAQRYGPDEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P592</accession>
    <name>A0A3N6P592_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_03330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93239">
        <property type="protein sequence ID" value="RQG93239"/>
        <property type="gene ID" value="EA462_03330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007516">
        <property type="entry name" value="Co_F420_Hydgase/DH_bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045220">
        <property type="entry name" value="FRHB/FDHB/HCAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007525">
        <property type="entry name" value="FrhB_FdhB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31332">
        <property type="entry name" value="PTHR31332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04432">
        <property type="entry name" value="FrhB_FdhB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04422">
        <property type="entry name" value="FrhB_FdhB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="540" mass="58932" checksum="AB340061E7C22EC0" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P692</accession>
    <name>A0A3N6P692_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91255">
        <property type="protein sequence ID" value="RQG91255"/>
        <property type="gene ID" value="EA462_04495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="406" mass="44722" checksum="D9DCF3E06F3C6F06" modified="2019-02-13" version="1">MSALDDVCVLDLTRVLGGPYCTMLLADMGADVVKIEPPGGDFVRDTPPFHEDDDSFGGYFQSINRGKRSLELDFTDEGDRADFLSLVETADVVVENYRAGTMEKFDLEYERLAERNPRLVYAAMRGFGDPRTGSSPKQNEPAFDLVAQALGGIMHHTGQPDGPPTKVGFGVGDIFTGVLHAVNILAALHYRHRTGVGQFVDTAMYDAMISLGERAVYQHSYTDETPTRQGNSHPTLFPYNAFEATDGYVVIAALTDRHWQNLCDRMDRPEWGLEYSTAADRLEHRERLGAGIDEWVGSQSVESVLDALNGAVPCGPVQDVTDVYDCEHTHRREMLVEATLPETDETVTIAGTPIKMAKTPPTPGDRAPLLDEHRDELLERDEIPRSSQRDGDSGRVGVTDGSSQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P710</accession>
    <name>A0A3N6P710_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF87 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91695">
        <property type="protein sequence ID" value="RQG91695"/>
        <property type="gene ID" value="EA462_04540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="582" mass="65494" checksum="8F5D847ADFAF5CBE" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA20</accession>
    <name>A0A3N6PA20_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93175">
        <property type="protein sequence ID" value="RQG93175"/>
        <property type="gene ID" value="EA462_02945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="137" mass="14740" checksum="151AADD2705FAC4D" modified="2019-02-13" version="1">MTDRTRDAAYTELDSDTWHQNDEGNYYIDCPECGSAASLMNVVTHGRCNAYLDRRTDDTELDERSMNCTATLWFELGYVSGPDDEQGADSEGASVAGPEATDLDAEDVETDDVDTGEGVSGEGQPPGADGSVDDDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHV4</accession>
    <name>A0A3N6LHV4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_16360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86804">
        <property type="protein sequence ID" value="RQG86804"/>
        <property type="gene ID" value="EA462_16360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="234" mass="25587" checksum="7C417C063A739265" modified="2019-02-13" version="1">MLEASDVDAGYGQVEILDEIAFEVPEGEILSIIGPNGAGKTTLMRVLMGLIPARSGSVELQGGLITDRPTHERVKMGMSLVTEKQNLFTEMTVAENLKLGSYTARGDEKEKRLERVFKLFPRLEERQSQHAGTLSGGEARMLALGRSLMTDLDILLLDEPSIGLAPHLIPELFEKIREINDRGVSIVLVEQRAQEALELADSGCLLENGCIVHRDDASAMLDSDEVIEQYLGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIR1</accession>
    <name>A0A3N6LIR1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87836">
        <property type="protein sequence ID" value="RQG87836"/>
        <property type="gene ID" value="EA462_13285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="81" mass="9244" checksum="D6AB8A8E949FCE56" modified="2019-02-13" version="1">MAQHCPVCGDVFEHVRRERPEDPSSHPDAIPGPNASIEVEDLCRTDDDDQWDRICHKAAIERAHGSIIPVLEVFYHYYGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ19</accession>
    <name>A0A3N6LJ19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87821">
        <property type="protein sequence ID" value="RQG87821"/>
        <property type="gene ID" value="EA462_13200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="235" mass="26332" checksum="B44150F6460A1936" modified="2019-02-13" version="1">MAEFVDLSQEIYSQHPVYFAHPDTVIWTDTTFEDSEYIFRTQAGIEDPTFTYESRTFQISEHGPSHVDSIRHYKPDGEPINEMSLENFHTPGKAVDVSHCDPEGYITVDDVRQALSETDQTLEKGDTLLLHTGHYDRTHPGRSYNEQHTGLTEAATRWIIDAGVANFGVDQPSPDNPSGTYPCHTLCTEFEVPHMENLCSIDRVVGEAFTFIGFPLPLRGGTGSPIRAVAKLEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ93</accession>
    <name>A0A3N6LJ93_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87961">
        <property type="protein sequence ID" value="RQG87961"/>
        <property type="gene ID" value="EA462_13950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="6680" checksum="A98E582147E00EDC" modified="2019-02-13" version="1">MSENTTRSRVTNQQADGAECPYCGSTETSLENAFGSTILKSQYHCDECMNVFEHIKWET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJC1</accession>
    <name>A0A3N6LJC1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative baseplate assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88001">
        <property type="protein sequence ID" value="RQG88001"/>
        <property type="gene ID" value="EA462_14180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011749">
        <property type="entry name" value="CHP02243"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02243">
        <property type="entry name" value="TIGR02243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="1">
        <location>
            <begin position="394"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="651" mass="72395" checksum="9A8719AD94B7F6AF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJI1</accession>
    <name>A0A3N6LJI1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88853">
        <property type="protein sequence ID" value="RQG88853"/>
        <property type="gene ID" value="EA462_10660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="136" mass="15342" checksum="926B0392940AC2F9" modified="2019-02-13" version="1">MQPSSLTKILCRADLMRGQITLLKVLYERDEPIGRGELAEKLRGGIHQDPEQSLTGVLGAFGRRINETDDIPGSPGTDAFIKRQQIDRETHYLLRPEAREAIGNVPALVRRFDEPWDKLLEPDSRIEAKNLVPNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJK7</accession>
    <name>A0A3N6LJK7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">purS</name>
        <name evidence="6" type="ORF">EA462_17270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86104">
        <property type="protein sequence ID" value="RQG86104"/>
        <property type="gene ID" value="EA462_17270"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="83" mass="9312" checksum="0AC2C8922C0A1648" modified="2019-02-13" version="1">MTAYTATVTVRLKRGVLDPEAETTKQALERLGFDLEGLRSADRFEVDLEADSADGARERADEMAERLLANPTIHDYDVEVDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJQ1</accession>
    <name>A0A3N6LJQ1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="4 9">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">purD</name>
        <name evidence="12" type="ORF">EA462_11275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="4 9"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88963">
        <property type="protein sequence ID" value="RQG88963"/>
        <property type="gene ID" value="EA462_11275"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="125"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG88963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="445" mass="47736" checksum="F93074C16A48EC41" modified="2019-02-13" version="1">MRETVLLIGGGGREHAIARALEDSEARGASSSRTQADGNEVDLYACAGNRNPGIARIATGFKSLETTDPAAVVEYAEDVGATIAVIGPEAPLEAGVADALEDAGVYAFGPKKADARIETDKAFQRRFMEENDVPGCPDFETFDDMEAACAFIDDYEGDLAIKPAGLTGGKGVKVIGDQVTAEEGTEYVRDSEYDRIVLEERLIGEEFTVQAFVANGEFETAPAVQDHKRAYEGDEGPNTGGMGSYSDATVSLPFMTESDYEEAVSIIEATVDALEDYRGILYGQFMLTAEGPKVIEFNARFGDPEAMNTLPVLETDFLDVLVAARDGEGPPELEFADQATVCKYGVPEGYPTDPKAGAKVRVDEESAGDALLYYASVDERGDGIYTTTSRSFAVVGIADSITEAEVIAEDALEVAGDEGLHMRHDIGKPDLVQRRIDHVESLRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJZ3</accession>
    <name>A0A3N6LJZ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_10910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88898">
        <property type="protein sequence ID" value="RQG88898"/>
        <property type="gene ID" value="EA462_10910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="115"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG88898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="619" mass="67936" checksum="168746B512351A1A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLG9</accession>
    <name>A0A3N6LLG9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87960">
        <property type="protein sequence ID" value="RQG87960"/>
        <property type="gene ID" value="EA462_13945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="29543" checksum="B4328B2D1725AF7A" modified="2019-02-13" version="1">MSTDSAVSTEARDAAYDLAVVLADTEFISAHRYSEWGMLGAPSIEEDIALSSVIQDELGHGRAAYKAAADLGETSVDDLLYERSVDEWRSPTVLDSQLDNWAEIVASLAVLDYATVLVYENLQNSSVDELSGIAEKVLQEESQHIQHGHVWLGVFADESEGEYPKEELQAALDSFVPQVAQWLGRNDGNDVLLEAGVFERSNEQMREEFLSDISSLLESHGYDVPDVDLEWDEWDDQSRRPSPPESTFEETVDEVTGRQHRYLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMF8</accession>
    <name>A0A3N6LMF8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="10">IGPS</shortName>
            <ecNumber evidence="4 10">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">trpC</name>
        <name evidence="13" type="ORF">EA462_09425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TrpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="4 10"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90198">
        <property type="protein sequence ID" value="RQG90198"/>
        <property type="gene ID" value="EA462_09425"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_A">
        <property type="entry name" value="IGPS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="12">
        <location>
            <begin position="30"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG90198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="289" mass="30000" checksum="40C9CA2BEF4180D5" modified="2019-02-13" version="1">MNSETELDSAVESILSTARERSVESADGAPVSVDARSLPDAIERANADGRVPVIAEVKPTSPTADGTRSDDPVELAQKMVAGGATAISVLTEPTHFGGSADALTRVREAVDVPVLRKDFVLDVEGMDLVEADLLLLIVRFVDDLESLVDAARERGFQPLVEVHDRAELETALEAGAKIIGVNNRDLARLDVDLGTFESVAPAVSELTGSGTATDGEAGVGAVPEGITLIAESGISGPADVTRMREAGADALLVGSAIMDHAEGETDVSENTRRLTRADDVGSDTSGSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMF9</accession>
    <name>A0A3N6LMF9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine pyrophosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86715">
        <property type="protein sequence ID" value="RQG86715"/>
        <property type="gene ID" value="EA462_16395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="192"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="400"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="553" mass="58720" checksum="9DB3250B53FB17FA" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMJ4</accession>
    <name>A0A3N6LMJ4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 9" type="primary">cheB</name>
        <name evidence="9" type="ORF">EA462_16660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86765">
        <property type="protein sequence ID" value="RQG86765"/>
        <property type="gene ID" value="EA462_16660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="8">
        <location>
            <begin position="155"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3 5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG86765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="351" mass="37375" checksum="AD349FA53C8B551E" modified="2019-02-13" version="1">MVRAVIADDSAVMRETLGKILEDGGIDVVGRAKNGVEAIEMIAQMEPDVATIDIQMPGLTGHEVIDRVMAENPTPMLVISSQTTRNADATFEALEAGAVDFIAKPSGDNSVDIWSQQDQIVDRVRAVADADVSGIDADPGRSERHTQPTVDAEDEFPNDPTLVIGASTGGPRVVERVLSDLPERAEFRILVVQHMADHYTKRFAKRLDERTAYEIREATDGDTIGPGEGVLAKGGYHLDVTRASGGRITVANDDGPKRHNVRPAIDVTMEATARRVSGNLVGVILTGMGADGAAGLESIKEAGGKAIVQDEATSRVYGMPKVAANRVDVDMVLPGERIAEGITNAFKGWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMT3</accession>
    <name>A0A3N6LMT3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89167">
        <property type="protein sequence ID" value="RQG89167"/>
        <property type="gene ID" value="EA462_12430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="668" mass="71790" checksum="82E0E81A36B9451B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMX4</accession>
    <name>A0A3N6LMX4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_12905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89257">
        <property type="protein sequence ID" value="RQG89257"/>
        <property type="gene ID" value="EA462_12905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="555"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="730" mass="77256" checksum="007D16BB40E57001" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LN28</accession>
    <name>A0A3N6LN28_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage II sporulation protein M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86975">
        <property type="protein sequence ID" value="RQG86975"/>
        <property type="gene ID" value="EA462_15090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="373" mass="39889" checksum="5E4AE0164354C062" modified="2019-02-13" version="1">MNGATGGDDSVVDEGERGTDHDGSERDDGSETGFEFGPERVDAKTDRPNDRSHPERGSASDPDRRIRVDLPSSEPDGPSRSDDPDRPPGGDPPGPEPGPEPGPNAVRNWSALLFGLAVVSVATAGVTAFWHDDAVATAGALVLASVFAGIAVGSRRTTPSMLESLDAAWIEHRRYAWFAAGLFAFGTGVGIVLLVAGVNLLEIIAELFDDGLFPELEDEDFELTATFFIRHNTPPFLMSIVGALSLGLLTAFIMFFNGVVVGNVSAIAGDAVGVDYILVGLAPHGIFELSALFVASGIGFRLVHRFVDRILGRREALFTKRYVYRTLALVGFAWLVLVLAAFVEAYITPELLEILFADRLAELESTTDSNAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LN42</accession>
    <name>A0A3N6LN42_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin biosynthesis protein CobY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86995">
        <property type="protein sequence ID" value="RQG86995"/>
        <property type="gene ID" value="EA462_15225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="199" mass="21479" checksum="A09B47F937983958" modified="2019-02-13" version="1">MCGGSGTRLESQREKPLHPIGGVPMVDRVATALEASRIETIYAAVSPNAPETRAHLERSSRLETIETDGDGYVPDLLSVLDGGELRTPVLTVAADLPLLEAAAVDRVLATHGDVNRSRTVCVPAALKRRLGASVESRLDSNDHLAPTGLNVVGTTDETEDMIDVRYTYRLAVNVNRLQDSRLAKALVDRSESVDRGRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP30</accession>
    <name>A0A3N6LP30_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89827">
        <property type="protein sequence ID" value="RQG89827"/>
        <property type="gene ID" value="EA462_07360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="61" mass="6036" checksum="F976BF6D373C020A" modified="2019-02-13" version="1">MTAQSESTDKGVGLALALGALASIGALLMITGAPDIEAAWGFAAAMVFSSLAVVGIHLYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPA7</accession>
    <name>A0A3N6LPA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91273">
        <property type="protein sequence ID" value="RQG91273"/>
        <property type="gene ID" value="EA462_04595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="134"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1073" mass="116852" checksum="0FFF49E9B40696F6" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPE7</accession>
    <name>A0A3N6LPE7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_08350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90007">
        <property type="protein sequence ID" value="RQG90007"/>
        <property type="gene ID" value="EA462_08350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="5">
        <location>
            <begin position="10"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="4">
        <location>
            <begin position="116"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="251"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="518"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="739" mass="80065" checksum="0775D5F882F471A9" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPN1</accession>
    <name>A0A3N6LPN1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90127">
        <property type="protein sequence ID" value="RQG90127"/>
        <property type="gene ID" value="EA462_09045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="152" mass="16215" checksum="E1ED0C3C4BE1CB3B" modified="2019-02-13" version="1">MTEPADSSETSGFRDFWSFYRRYTATAVHTAATAGLAIFGLLVFVDPLFAVVAIACYLAPPIVLYVRTDEPTYPQASDPSTNASGRELDTEADPVADEMTETAVNGVSESTISNTDTDSDNGDSDTDRDNGDTDTDSDTDSDSDDRDADSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPQ2</accession>
    <name>A0A3N6LPQ2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="6 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pyk</name>
        <name evidence="18" type="ORF">EA462_05865</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 14"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91488">
        <property type="protein sequence ID" value="RQG91488"/>
        <property type="gene ID" value="EA462_05865"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="15">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="17">
        <location>
            <begin position="353"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="16">
        <location>
            <begin position="501"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RQG91488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="585" mass="61645" checksum="13F6D5265ECE6F48" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPQ5</accession>
    <name>A0A3N6LPQ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polymer-forming cytoskeletal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90157">
        <property type="protein sequence ID" value="RQG90157"/>
        <property type="gene ID" value="EA462_09210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="361" mass="36003" checksum="C02729A6A22D16F2" modified="2019-02-13" version="1">MPERSTLRRRVVVLVALAVVLCATVPATAAAQSSSQVGGTVTVSEGETVDSLEAFAGTVVVEGTVTGDVSAAAGDIRIHGDVGGDVEAAGGSVTIAGTVDGDVQAASGSLEITDGATVGGDLSAGAGSATVDGVVDGDVAIGADTIRLGDEAAIAGDLRYGGDLVGNTGAVAGDIRHDSSLGGEFAPTLDPIVSWVFSLYVLALNLLIGAALLALFPRFSAGVSASVATDPVRTGLVGLGVLVGVPILLIALAITVVGIPLSFVGGFAFALAIWIAIIYGRFAVAAWLLSAVGVGNRWIALVVGLVAGAAVVQIPYLGTPINLIVLLLGLGALARGVYGHRRALRDRDREPGVRPEETPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPY9</accession>
    <name>A0A3N6LPY9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91603">
        <property type="protein sequence ID" value="RQG91603"/>
        <property type="gene ID" value="EA462_06530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="126" mass="14326" checksum="352F50ED056B5EA6" modified="2019-02-13" version="1">MEDIRNESVDPDQPSRIDPSCYCRLGGVLELLSRRHAIQVICLVGAVGPVRYGEIEDALGEISSSTLSSRLSELVEAGYLEREQYDEIPPRVEYELTMTGEQLRQRLHPLLEWAEIHEEFEEPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ10</accession>
    <name>A0A3N6LQ10_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91648">
        <property type="protein sequence ID" value="RQG91648"/>
        <property type="gene ID" value="EA462_06785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="270" mass="27918" checksum="56A185E624779914" modified="2019-02-13" version="1">MRGFRMVVAVVLITVGLTVAPVAGVVGSAAETESDSDADSNETVSVSSFMQSSAADAESTVESGLFETEYESAANDTRADLVRDRTDDLEERLAALQAEREELRENATNLSSAEYNARITRLSVEVASLEQSVDRTIPRANETGLESDRLDELRANASELAGPEVATIARGVAGFDRQPGGPSTDGDDGVPGQSGIDTPPGQDSTPDDRETGDGNGTTQTADDGPTPNGTDDGTDRNETGADEDDRGTSNGPNTASSDTGAGSADETPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS72</accession>
    <name>A0A3N6LS72_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC family peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92723">
        <property type="protein sequence ID" value="RQG92723"/>
        <property type="gene ID" value="EA462_00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="208" mass="23022" checksum="4F803F0F329962D1" modified="2019-02-13" version="1">MTTDDLRHTATQRKGEIEHGLDAGGHLEFIDWLEANPEDGALEFRATGDTEAVANRTTATIGDWALGGEEMGGDREHVLEFGLPPELEEAMAYVEPTDRYEAIEGALAGLTACINGTIVWNAIREGIDVDEVTTTVRAPVDLRALFGIHDVEKVHDMYGELEIDVDVTGDLSAEERSMVREFPKRSPVYNLVTLEHPNRPRLEIHSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSH4</accession>
    <name>A0A3N6LSH4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P protein component 2</fullName>
            <shortName evidence="5">RNase P component 2</shortName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pop5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnp2</name>
        <name evidence="6" type="ORF">EA462_09630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90234">
        <property type="protein sequence ID" value="RQG90234"/>
        <property type="gene ID" value="EA462_09630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00755">
        <property type="entry name" value="RNase_P_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="SSF160350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="114" mass="12737" checksum="4B8A77B4452C382C" modified="2019-02-13" version="1">MKHLPKHLRPRWRYLVVSLETWPGDAVDRRSFQRECWYAGQNLLGDPGSAHADLSVVRFDFENATGTAIVRVRHGRTEPARAALACIDEIDGVPVGVRVERISGTIRAATDETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSN4</accession>
    <name>A0A3N6LSN4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90324">
        <property type="protein sequence ID" value="RQG90324"/>
        <property type="gene ID" value="EA462_10135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013971">
        <property type="entry name" value="HalX_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08663">
        <property type="entry name" value="HalX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="190" mass="21575" checksum="0DA9A9AD289410C7" modified="2019-02-13" version="1">MSDELRVLVVDDEARLADLFATWLEGEWSVDTAYDGEEALEKMSDTVEVVLLDRRMPGLSGDDVLKAIRDEGYNSRVVMVTAVDPDFDIIEMGFDDYLVKPVSKDELLEIVEEVTDRSEYESDILEYYALVSKKALLESEKAERELTANEEYQDLRGRIEELEARVDESVSGLSSHDDFVGAFQDLESEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSR8</accession>
    <name>A0A3N6LSR8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93018">
        <property type="protein sequence ID" value="RQG93018"/>
        <property type="gene ID" value="EA462_02055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="312" mass="34251" checksum="72CC4F2A20B663E6" modified="2019-02-13" version="1">MQGKRVLITGGAGFIGSSLANHLVDRNEVLVVDDGSLGTPANVSDSVSVIERSVVDSTLPTDVDVVFHLAALSSYAMHEADPQRGVRVNVEGFVNTVEQARRDGCDVIVYASTSSVYGDRAEPTAESLEVGASTGYEASKLSRERYGEYFHDRYGMELTGLRLFSVYQGYHGGESHKDEYANVIAQFADDVANGRSPELYGTGEQTRDFVHVEDVVRAFELAADYRFNGVFNVGAGERHSFNRIVEVLNELLGRSVEPTYVENPIPEHVYVHDTCADCNAFRKATGWSPEIDLEDGLRRVCAPYAPDRLEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LST9</accession>
    <name>A0A3N6LST9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Capsular biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93048">
        <property type="protein sequence ID" value="RQG93048"/>
        <property type="gene ID" value="EA462_02215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="127" mass="14947" checksum="F1BEE9AAFFD2A6C3" modified="2019-02-13" version="1">MNPDEHNRLVVDVDGVLVKKDSDTEYANREPHEDVVERLREYADDGFYIILYTARNMRTHEGRIGKINAETAPVLNEWLDEHDIPYDEIHYGKPWCGYDGFYVDDKAIRPSEFTELCVEEIREDIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSX5</accession>
    <name>A0A3N6LSX5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">infB</name>
        <name evidence="9" type="ORF">EA462_06955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91677">
        <property type="protein sequence ID" value="RQG91677"/>
        <property type="gene ID" value="EA462_06955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_A">
        <property type="entry name" value="IF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004544">
        <property type="entry name" value="TF_aIF-2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00491">
        <property type="entry name" value="aIF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="14"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="601" mass="65453" checksum="59E5A105A875D6D0" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV66</accession>
    <name>A0A3N6LV66_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2150 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91554">
        <property type="protein sequence ID" value="RQG91554"/>
        <property type="gene ID" value="EA462_06235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014518">
        <property type="entry name" value="UCP022079"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09920">
        <property type="entry name" value="DUF2150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022079">
        <property type="entry name" value="UCP022079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="192" mass="21054" checksum="96DBAE5BD7124CBE" modified="2019-02-13" version="1">MSNPPTEFYSEERWQNWIDRIKDEEIDPEDESSARLLLNLQDDTAIAIAKIVAAYDDDELEREDALGEIDDVRTIVLDEVDIEDEEKLILVDGVQTSLVCVFFAAEEYIANGPAEDGSVGDYLGAAADAEAEEDLDAALGYAAQAGTLIVDGDDLDISIAEDLEYGLVTEWINGLDSLQSAMSDPEVVEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVT0</accession>
    <name>A0A3N6LVT0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92887">
        <property type="protein sequence ID" value="RQG92887"/>
        <property type="gene ID" value="EA462_01300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="162" mass="18044" checksum="F78ABBF064BF986E" modified="2019-02-13" version="1">MAPDEIDNVDKGIIYLLQQDARKRTVADIGEQVGVSSSTVTNRIDRLEEQGVIKGYHTIVDYTKAGLGHHLLVTATVPIPEREERVDEIMEISGVVSVRELLSNNANLSLELIGHSQDDIEESLIELDSRGVDIESVEIMKQEQAQPYNHFGQEFTDEDDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXY5</accession>
    <name>A0A3N6LXY5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZIP family metal transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_14885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86941">
        <property type="protein sequence ID" value="RQG86941"/>
        <property type="gene ID" value="EA462_14885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="282" mass="28514" checksum="BF3098C003DAC999" modified="2019-02-13" version="1">MTSLGEVVVVAAIAGCVTGLGALPVLVTDRVSHRVYDGALGLAAGIMVGAAVFALIVPGLELGSPSEVVAGLLLGGTFLLSVNAILPHMHLRFRRDRIEGTAVVDDPLQDDGGPGTSERERDEPTVDDHSSAEDLRRAALVGSTVTIHNVPEGLAVGIAFASGETALGFAIATAIAVQNVPDGFAMAVPAARAGVSRSKTVLYTTLSGGVPEPIAAAIGFSLVIVVSGLFPIAAGFAAGAMIAVVFRELVPSSHGHGYADTATATFILGFALMLLVDTVLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY77</accession>
    <name>A0A3N6LY77_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87061">
        <property type="protein sequence ID" value="RQG87061"/>
        <property type="gene ID" value="EA462_15625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="411" mass="45552" checksum="CE5451D3472C8BE3" modified="2019-02-13" version="1">MSREGSNVGGLANRREALRVTSLSILGGLAGCMQPLLEETPDEQSADTHSTPGNGDDAGGSDDDEAPASGEDTDGDDQPDELELTEAWHDLELSHVYVSDGQFVARDSPDVYVLTRDGEVVWSTESSDPDRYSIWPMNGDGFARTDEFAFINYTSFTSEPGEYDGRIYAYDGDDGTELWMHETGLDRLRGLDATTERVYYTGTPFDDEAVPIRALSVDSREIEWERTIGTEHPYGPVLFDSTLYVSDDVLYALDPDTGEIEREHDVSGRFARRGDTLYFTGHESVQAFDLATEAVEWELTLENAIHSQIAVANGTIYAGDDMGYVSAYDADDGSERWEYRLVGSVTGSPRYDDGIVWAFDDTSTVWALDATDGTPLYRRETEAATDDPMAPLEGRVYVPEPYYTAYDVERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYV8</accession>
    <name>A0A3N6LYV8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Replication factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86932">
        <property type="protein sequence ID" value="RQG86932"/>
        <property type="gene ID" value="EA462_14840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="309" mass="34279" checksum="5C880998E80056A4" modified="2019-02-13" version="1">MSDVRQHAADIHEQFSDHIDVTVEEIEERLHTLVDEYKVPTDEARRSVTNHYLEEAGLEHEDISSGSSQRVSVEDVEEPEQWVDLTAKVIELWDPRSDAVAQVGLLGDPTGTIKFTKWAKSDLPSLEEGGVYELGNVVTDEYQGRYSVKLNSTTVIEELDEEIEVGDDTSEIEGALVDMQSGSGLIKRCPKEDCTRVLQNGRCNEHGEVEGEFDLRIKAVVDDGIDAHEVIFDKDATEELTGLSLEEAKDMAMDALDTTVVADEIADDIVGTYYRIEGPTFGRYVLADDVEELGGPTDAESLLIRARSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZV2</accession>
    <name>A0A3N6LZV2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_10645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88850">
        <property type="protein sequence ID" value="RQG88850"/>
        <property type="gene ID" value="EA462_10645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="128" mass="14311" checksum="CFDAC7BBEB1AB25E" modified="2019-02-13" version="1">MSSESVQPEVDARTLRAAREHMTVIEEGDALFEVTTQSGSAYTVDLREPACSCPDFQYREEVKECKHVRRVRIEVGQVDIDALSESLSEQANDIQQDAAELIQAADELGETATKLEDAVERLREVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M098</accession>
    <name>A0A3N6M098_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase family protein subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89030">
        <property type="protein sequence ID" value="RQG89030"/>
        <property type="gene ID" value="EA462_11660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="299" mass="31404" checksum="31C08F755D57A001" modified="2019-02-13" version="1">MYPAPFEYVSVESTAEAVDSLSEYGDREVTLLAGGHSLLPTMKSGLSTPEVIVDLASVESLYGIDHDDGVTRINAMTEYAAIERDETLWNENPVVPEAAAEIADVQVRNMGTIGGNIAHSDPAADLPAAVLAADATIHALGPDGRREIPAANFFEAMFTTALADGELLTAIDVPHLGENDAAAYVKKASASSGYALVGVAAVLETDGEEITDARVAANGAFDHAMALEPVETELVGGSLDDDGVAERAAAFVTDDVESYVLMDDEQASGEFREHLLEVYTERALETTIARVDGGSSANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0C7</accession>
    <name>A0A3N6M0C7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87994">
        <property type="protein sequence ID" value="RQG87994"/>
        <property type="gene ID" value="EA462_14145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="537" mass="60140" checksum="837243112083223F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M189</accession>
    <name>A0A3N6M189_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88841">
        <property type="protein sequence ID" value="RQG88841"/>
        <property type="gene ID" value="EA462_10595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="105" mass="11853" checksum="5E7E5A45AED4462E" modified="2019-02-13" version="1">MYQGSEKYFIRTFIARFGFLYGAGGTVNTALQLLVINIGLLSRQPQNFETLPYFVEAWVSIVLPILPPYTAGDVLNVLFNLLIAALIALSWTLSWSEGMYRHHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1K0</accession>
    <name>A0A3N6M1K0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteasome assembly chaperone family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88971">
        <property type="protein sequence ID" value="RQG88971"/>
        <property type="gene ID" value="EA462_11315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004426">
        <property type="entry name" value="CHP00062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00162">
        <property type="entry name" value="TIGR00162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="256" mass="27829" checksum="DE08387C5A749C87" modified="2019-02-13" version="1">MDELEIDAVAEVDLDDPVLVEGLPGVGHVGKLAVDHFLEELEDESTLVRRIYSQEFPPQVSIEDGVSELTCAELYAVSVPDGRDLLLLTGDHQAQTNEGHYLLTDAFLDVAQEFGASELYALGGVPTGELIDEYAVVGAVSHEPMLAELEGDGVEFREDEPAGGIVGVSGLLLGLGERRGFEAACLMGETSGYLVDPKSARAVLEVLEARLDIELDYESLDERADEMEDVIGKIQEMEQQQQGMEMPTDDDLRYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M218</accession>
    <name>A0A3N6M218_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89840">
        <property type="protein sequence ID" value="RQG89840"/>
        <property type="gene ID" value="EA462_07425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="259" mass="28798" checksum="C7224B4951447458" modified="2019-02-13" version="1">MDDRGVTELIGYSIIFGLVLLSFSMLFLVGTTTVSDSRDRTQINNAEAAFEILASNMDDHANDREVGRATEIRVTDAALYFGPSESVNVTVSPDGSEDNVTVYDRSTEPIVYETQQGERVVYSNGAVFREDTDTSRMVREPQTKIDENRTVLPQVRFTSTEGGISVGGSQTVLVRTERLTSRFEQNTTSDGYELEIEITTDERRGDAWRSYFGSYELLECAESDVVEQPDGNVAVTCETTGQMTSEIYVPETRLQGEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2X3</accession>
    <name>A0A3N6M2X3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_09330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90180">
        <property type="protein sequence ID" value="RQG90180"/>
        <property type="gene ID" value="EA462_09330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="339"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="487" mass="51209" checksum="2FACE472B0926CEE" modified="2019-02-13" version="1">MSIANRIGRGVKATLGADVARLAAKGGITLLLTRVFLEPDEYGLVFLAIAVFSIATVVGSLGIPKSTAKFLAEYREKDDAQVHHVVRISATALAAVVVLVSLSFYFLSDWIAGVYDEPALAPLLAIGAAYIVVKVAYVYVRISFQGFGRVPLSAATTAVSSVGQLGCVVLFLSLGFGTIGAIGGYVAGYALGVAFGAVFLGRLLREYPRSGPPESGLARRILEYSVPLTASQGGNLLYKRVDTLLVGFFLTPLAVGFYELAKQVSEFVIAPANSLGFTVAPTFGEHKSGAKLERAARVYEQSFEVILLLYLPAVAGIVLLAEPGIQFVFGPAYAGAAPVLQIFSAFVLFQALDKITNDSLDYLGRATERAIGKGITGTLNVGLNIALIPTIGVVGAAISTAVCFAIMVTYNVYLIDCELPLDRHRMAKSIAAVSVVTGGMTAVVYAAQPYVDGLFTLFGAVAVGVFVWAVLSVAGGLLDLEEVRSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3S9</accession>
    <name>A0A3N6M3S9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89871">
        <property type="protein sequence ID" value="RQG89871"/>
        <property type="gene ID" value="EA462_07605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="250" mass="26529" checksum="0542F27233BC3599" modified="2019-02-13" version="1">MSTHSGRGGGGGVVGAIRADLGRLHGAWMELAFPRQRGRGHSVMGKWKPETLPQKIGYHVWSVLGTIGLLALYPLTVLGFATRYYAVKLDSTRTRLGIVGVTGVAILAWGTLTVVAHLRLPFDAFLAVAAASLVGVLSTALAAGFSKTGGRLVSVLFAYPFAMTAIFLPPVVAALVTPSLEGVILEPSYDFAIWILDTILHVGGLNEWLRTNFTLEGAAYAGMWVGISFPLGWFLGIPIALADLVRPSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3V5</accession>
    <name>A0A3N6M3V5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86807">
        <property type="protein sequence ID" value="RQG86807"/>
        <property type="gene ID" value="EA462_16615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="7183" checksum="E0ABBFE32F0084D2" modified="2019-02-13" version="1">MDIIDGTKIECARCDEVTSLDDVNVLGKENNRSYAKPLCDDCLKKVGVPKGYELERDVSYLKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M529</accession>
    <name>A0A3N6M529_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90361">
        <property type="protein sequence ID" value="RQG90361"/>
        <property type="gene ID" value="EA462_08065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="246" mass="26664" checksum="CD2D8EF0A8406E51" modified="2019-02-13" version="1">MTVQFGAVTIEWLGLGTVRLEGETGVVIYVDPGPEEYGILDGYRPRDGDLVLVSHGHHYDPDSIRRVAHEEAIVAVHNSIDVRELDHTDESPETLPFVVERVGADESFVLGPLDLFTTPAYNDPAGSHTDERGAPYHPEGDGCGFAVTVDGVSAFWPGDTDALAYHENLDIDLFVPPIGGTFTMDRHEAAELAAAIAPDLVLPIRYDTFEEIAADEAAFVVDVARRGVPVVLDDQPDSVPERPGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M565</accession>
    <name>A0A3N6M565_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_13305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87839">
        <property type="protein sequence ID" value="RQG87839"/>
        <property type="gene ID" value="EA462_13305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="58"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="196"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="259"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="500"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="536" mass="58420" checksum="331EA506D47AE0A1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5D8</accession>
    <name>A0A3N6M5D8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87939">
        <property type="protein sequence ID" value="RQG87939"/>
        <property type="gene ID" value="EA462_13840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="238" mass="27753" checksum="AB4A834A7FA427D7" modified="2019-02-13" version="1">MSDTQSQEAVTFLNETTAEFRNEMGELVQKYYSDEYFDEIGGPEAVVHQVVPDLAWREWFNGAMIPARQMHYVFEQGDPYYRDRDIIVGLSEQIRDEVKHANTLANISRRFGVDMDFAQWDQWLDEDVAEALVAQHQAAMAPEYEGPQYSAVGMQCSTEIIAVHTLHRMANYMESSYPNAADQMREIANDEDDHVHVGRMIVERFSTPEDIPVLREITETKRERIENMLRTRYERTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6A1</accession>
    <name>A0A3N6M6A1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91580">
        <property type="protein sequence ID" value="RQG91580"/>
        <property type="gene ID" value="EA462_06395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="158"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="359" mass="38635" checksum="63ED65D483B76328" modified="2019-02-13" version="1">MGLESYFDNFARRDWQETDPDGTVRMAIVGIGGFSRNRALPAIDTADYCETSVLVTGSPDSSAEIADEFDVDTLLSYEEFLDGRATDAYDAVYIATPNATHGQYATAAAEFGKHVICEKPLETTVQDAREVIDACEDAGVTLMTAYRLQFEPSIRRTRELITDGVIGDVVQIHAGFSNPLLEHAGADTWRLDPDLAGGGVLVDLGVYPLNTIRFLLDCDPTVVTACTYSVDEAFADVDEHVAFQLEFPGAVTASCTASYNAHAASGLRAVGTDGMVSVSSPFGGVVPHDIYVECGDVGMEYRGAPSDEVIEEFDYFGYCVLTGTDPEPDGVDSLRDIVTVDSTYEAAESGVSVEIPYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6K9</accession>
    <name>A0A3N6M6K9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="6">2.3.3.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_06565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91730">
        <property type="protein sequence ID" value="RQG91730"/>
        <property type="gene ID" value="EA462_06565"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="510" mass="53736" checksum="100922F4C92F14D5" modified="2019-02-13" version="1">MPVQHSTEQTIPSDRTVRLLDTTLRDGEQAPGVSLSPDEKVEIARALERTGVDVIEAGSACTGAGERQAIARVTDLDLEATVTSFCRGMRSDIDLALDCDVDGVHIVVPASDRHVEDKVGTSREDNLERTAELVEYATSHDLWVEVIGEDGSRADLDYLEELGTTALETGADRTCFADTVGHTGPERTAQAVERLAQLGPVSAHTHDDLGLGVTNALAAISAGADLVHCTVNGLGERAGNVALEEVAIALSHVYGVDTVELEELYDLAQIVSRSTGVQLPPNKAVIGENAFTHESGIHTDGTLKDDKMYEPYAPETVGRERRIALGKHTGRAGVKATLEEHDVEAGDDEIAEIATRVTELGDRGRRVTDADLLAVAEDVTGDDRERVVELLDLTATSGGAVPTASIRLEVAGEERVASGTGSGPVDAAVSAVREALGSAADAELESYRVDAVTGGTDAVVTVEVTMAKDDRSVTVARSEADITRASVEAMVDALDRLLAVEAEPLAPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M747</accession>
    <name>A0A3N6M747_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91161">
        <property type="protein sequence ID" value="RQG91161"/>
        <property type="gene ID" value="EA462_03970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="78" mass="8759" checksum="9B7AA237EC0BE0C5" modified="2019-02-13" version="1">MPLPGDVITILAALFLLFGIPAILFSLIFLYTGYIRYDANRYLEQLETEQGEKSVESGGATETDRTRIESESQRDAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7V8</accession>
    <name>A0A3N6M7V8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit beta</fullName>
            <ecNumber evidence="6">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">psmB</name>
        <name evidence="9" type="ORF">EA462_05520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91431">
        <property type="protein sequence ID" value="RQG91431"/>
        <property type="gene ID" value="EA462_05520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="4 6 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="5 6" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5018342162" description="Removed in mature form; by autocatalysis" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023355691" description="Proteasome subunit beta" evidence="6">
        <location>
            <begin position="49"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6 7">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="243" mass="25768" checksum="069351D97FEA0D57" modified="2019-02-13" version="1">MRTPIDDSEFSRTADQLDRSPDPYAPEIGSMPQNELTRADLDNVNKTGTTTIGITTTDGVVIATDMRASLGGRFVSNKNVQKVEQIHPTGALTMVGSVGGAQSFISSLRAEVNLFEARRGENMSIDALATLAGNFARGGPFFAIHPILGGVDDDGSHVYSIDPAGGVMEDDYTVTGSGMQLAYGHLEQAYEDDLSNDEATTVAARGIKSAAERDTGSGNGVFLCEITEEGVDIHGHHDFDDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8U3</accession>
    <name>A0A3N6M8U3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89896">
        <property type="protein sequence ID" value="RQG89896"/>
        <property type="gene ID" value="EA462_07750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="174" mass="18971" checksum="AB0F7FC4DD3CED61" modified="2019-02-13" version="1">MMTNLRTRRRVLQLTGTGIAASIAGCSDLSAIDGENGDGAEEDGHLTALAEPDASDLQELQQRAMAGELSEEEAIQRQQELFEDAIDDFEGRVDSEAEADLSIEEEEQEGGVYRVDGSADVLVDALRTGEISVLAGTDLYDQIIQQREQQQEQQPEEVPDGEEIEGQDGSEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M957</accession>
    <name>A0A3N6M957_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein pelota homolog</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pelA</name>
        <name evidence="11" type="ORF">EA462_08450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90026">
        <property type="protein sequence ID" value="RQG90026"/>
        <property type="gene ID" value="EA462_08450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01853">
        <property type="entry name" value="PelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023521">
        <property type="entry name" value="Pelota_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="Transl-rel_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PTHR10853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="SSF159065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG90026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="355" mass="39864" checksum="6C20C926E1CDCA78" modified="2019-02-13" version="1">MQIKDRERIEGGRERVTVVPESVDDLWHLQYVLEPGDRVAGDTTRRIQRNDEQMRDTGGEREHMWVAIAVDDVEFHKFANRLRVGGEIVACSREDQLDFHHTLNVEERDELSIEKQFKPDQEARLEEAEEATENPDVAIATVEEGQAHVHTVAQYGTEERATITGPTGKGEYARERSELFSELGDVLKRMDVDAIILAGPGFTKQDARKYLENNEPEVAALLTMVDTASVGDRGVHEVLKRGAVADVQQETRIESEAEYIDELTRRIAEGAKAAYGPEQVEQAAEFGAIERLLVLDDRLRKERGPDGEWSVDVDEIVRTTEQKGGEVTVFSSEFPPGQQLSNLGGVAALLRYRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9F1</accession>
    <name>A0A3N6M9F1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1405 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90146">
        <property type="protein sequence ID" value="RQG90146"/>
        <property type="gene ID" value="EA462_09150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009845">
        <property type="entry name" value="DUF1405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40042">
        <property type="entry name" value="PTHR40042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07187">
        <property type="entry name" value="DUF1405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="233" mass="25892" checksum="D57F08DFA1B25F7D" modified="2019-02-13" version="1">MSVVTELPARDPLPRYLAPVPKALEDLGLRLAWVVVAINLAGTAFGFWYYSGQFARTPAVMWPWVPDSPMATLLIALAIASWKLGYEQPWLTALAFFGNIILGLWTPYTLLVFYETYATQTHPVMYQFLFWSHLGMVVQALVLHRITDFSIHAVAVAALWYTSNLIVDYFVPVVGEPHHTTIPVARDTAMFLGADALGVIAAGEVTFTLLALFLALSTRAKTYEIALERARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9G6</accession>
    <name>A0A3N6M9G6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92920">
        <property type="protein sequence ID" value="RQG92920"/>
        <property type="gene ID" value="EA462_01480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="73" mass="7884" checksum="48AEC8223DF1945D" modified="2019-02-13" version="1">MSSDADVDPADYPALEDAEVTVYENDHGLHIADDEVTEVSSQGQTPEKALENLAAAVESYREATADETGDDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9I5</accession>
    <name>A0A3N6M9I5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92940">
        <property type="protein sequence ID" value="RQG92940"/>
        <property type="gene ID" value="EA462_01600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="72" mass="7839" checksum="7F52570903C834C4" modified="2019-02-13" version="1">MREILNSDTGFYYAIGAFTIAVFVVAVIALSVVAPSGIGTRELIGLVGGFVLFMLVYFVSVTVHRLEERENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9N1</accession>
    <name>A0A3N6M9N1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I-D CRISPR-associated protein Cas5/Csc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cas5d</name>
        <name evidence="2" type="ORF">EA462_02015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93010">
        <property type="protein sequence ID" value="RQG93010"/>
        <property type="gene ID" value="EA462_02015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017576">
        <property type="entry name" value="CRISPR-assoc_prot_Csc1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03159">
        <property type="entry name" value="cas_Csc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="248" mass="27874" checksum="39A944A44F6C5C8F" modified="2019-02-13" version="1">MQIIEATLTTHGKVGFASREVGRMTDTDPCILNTALHYALGIASGRYVDVVHQPTYIEDTADVVDEVYVTPAAPARVERQGTARTEYLTTNRNARSDTYATPNYPATDDPTGRADKNLPTFERERALAPENTFRFYVFPYGQDASEVATRLPSYIRLGKKRGKGHVSYRIVDAERRSGRFNLGHPLSVYDHDTTPTGGVVMKQMQPTPVWFEGEFDADHYAIEPPYRNESRIYYPAGAKFLATKRDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9X3</accession>
    <name>A0A3N6M9X3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93120">
        <property type="protein sequence ID" value="RQG93120"/>
        <property type="gene ID" value="EA462_02640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="154" mass="16452" checksum="DF24B41928040E6D" modified="2019-02-13" version="1">MIRYVLAVLLTVALVALSVPAIEHGATVQSDRQVDGDVGAIERAAVSLIEHEELPPDGQPPPQRFVTVSLPDDSMTTTPVARFEIERTSDHTSVVTVSLEDSSPRTIGIDAPIVYATAAENRSLELTGTGNEVSLLFYLDTDPAGERVVVATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MAB6</accession>
    <name>A0A3N6MAB6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93270">
        <property type="protein sequence ID" value="RQG93270"/>
        <property type="gene ID" value="EA462_03505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="125" mass="14154" checksum="C0774E32E2AC100D" modified="2019-02-13" version="1">MVRDPLASGSTPSAAEICSALDDPDCREIIRNLEEPMTASELTKRCDIPQSTLYRKLELLTESTLLEESTDIRRDGHHASTYVVAFDEITMELDEDRSLSVQIDRPARSADERLAELWSEVRKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MB69</accession>
    <name>A0A3N6MB69_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92701">
        <property type="protein sequence ID" value="RQG92701"/>
        <property type="gene ID" value="EA462_00245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="381" mass="43599" checksum="BB2B9A145EC33F08" modified="2019-02-13" version="1">MSEHALRADERSPLERLEAARECFEEADRRIDEHGGDAVADASEAYRNATDLLDSYVDRATGTGRENFTAYIQLEGQFASLVDGLPDDLRGRDAFEDALDAIDKRRLSESDFETAHAALEPASRYVELIDERESAREALAEARKVASKRRRTIDDEIDERERLLELATADLDAPVERLRKPIDRYNERVLEAFTEYRLETSAREVFSVLERSAWYPFVDFERPPDDLRAYVEESSDGEYTIPELLEYAGYSRSKLSHYVEDADVLKRRVATQQTYLDDIDGEPLTIAWPPAPTGVLRRRTRERRPFVERVADEETVALLREIRLLTADPDYDRLQTAAKAVAKLTPDERDRLASGRVEDELKALRTERDDLATALEIDDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC44</accession>
    <name>A0A3N6MC44_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-layer glycoprotein N-glycosyltransferase AglJ</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aglJ</name>
        <name evidence="3" type="ORF">EA462_02310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93061">
        <property type="protein sequence ID" value="RQG93061"/>
        <property type="gene ID" value="EA462_02310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026456">
        <property type="entry name" value="GCTrfase_AglJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04182">
        <property type="entry name" value="glyco_TIGR04182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="33"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="340" mass="37349" checksum="CE78F8C71C9D0236" modified="2019-02-13" version="1">MENEGARTETLERGGEVLAMTERTHEISADEVCILIPTLEEAATIGDVIDGFHDHGYTNVVVVDGGSEDDTRRIATDRGAQVLVQSGTGKGQAIREVLEYVDVPYVLMLDGDGTYDPADAERMLEPLARGYEHVIGNRFADMDDDAMRALNGFGNRLINRSFRFIHGADYDDILSGYRAFTTESFERLSLDSDGFTIETELAVECVKHGVDTAIVPISYSARPEESETNLHPVTDGGTIIFALYSLAKTNNPLFYFGSLGVAGIASGGIVAAYVLWRWVQYGAGHEILALVSAAAVLLGVQLLMFGVLSDMLVTLHREQRRRLEQITRDAREHESGRKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC94</accession>
    <name>A0A3N6MC94_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase</fullName>
            <ecNumber evidence="3 9">4.3.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">FO synthase subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">cofG</name>
        <name evidence="11" type="ORF">EA462_04915</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The FO synthase complex consists of two subunits, CofG and CofH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. CofG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.32" evidence="3 9"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91326">
        <property type="protein sequence ID" value="RQG91326"/>
        <property type="gene ID" value="EA462_04915"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="36"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG91326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="42179" checksum="C0CD3C4E1D8C7459" modified="2019-02-13" version="1">MIPGASEYGVDIAVDEADVEALCSIEPADVEAPAALTFARNVFVPLTTACRYTCTYCTYFDPPGQASLLSLEEVRKICRRGADAGCTEALFTFGDDPDDRYTDIYDQLVTWGHDSIHSYLREACEVALAEGLLPHANPGDQTREQMAEVADVNASMGVMLESTATVDAHAGPRRKEPGQRLQTIRTAGELDVAFTTGILVGIGETWRDRAESLLAITELHERYDHVQEVIVQPVVNNERWSEGSPDTETMRRVTAMARVALPEEVSVQVPPNLAPARELIDCGVDDLGGVSPVTDDHINPEYAWPALRELEEIAASSDLPLRERLPVYERFFPPALRPDGFDDVAASGREWISPPIREALSADDDAGERYRRVLESSENRTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCC4</accession>
    <name>A0A3N6MCC4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF91 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93141">
        <property type="protein sequence ID" value="RQG93141"/>
        <property type="gene ID" value="EA462_02760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="258" mass="27770" checksum="D83FDCD4D86A4FC1" modified="2019-02-13" version="1">MIDDAIRVLAGDCTVISEAADREEYRGRVTTIVKPDNTVLVHDVDGYQPVAWLTRADSVSSDRTDGFTLVAKKDEQTLRIAAHEQDGFAHYPSSSAGVPVGECPDCDGALVRSDGVHCVGCGTRYGVPADATICTDQSHCDCGLPRMRVERGLAFNVCLDRSCESLDEAVTEAFDREWSCPKPSCDGDLRILRRGGLIAGCEQYPDCETGFAVPTGVVDGECRCGLPSFETRTGTRCLDATCERVLERPPGAEPASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MG36</accession>
    <name>A0A3N6MG36_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92886">
        <property type="protein sequence ID" value="RQG92886"/>
        <property type="gene ID" value="EA462_01290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="169"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="338" mass="38550" checksum="9CAE676E19BF3BED" modified="2019-02-13" version="1">MNMLVDGEWQTDAYESTDGDGSFERGETTFRDRIRDDPDAEFQPEAGRYHLYVSYACPWAHRTLLVRALTGLEDAISVSVVDPYRGEDGWQFTPDKAGCTRDHVHGADYLRELYVRADPDVTCRVTVPVLWDKREGTIVNNESKEIMRMLDTEFEGVPAGEDSSADLYPDGYREEVDRIIEEIYDPINNGVYRAGFATEQEPYDEAVDTLFDALDHWNDVLAEQRYLAGDRLTEADIAMFTTLVRFDTVYHTHFMCNVQYIREYDNLWPYLRDLYQTPGVAGTVNLSHIKEHYYTTHPDVNPSRIVARGPDLAFDAPHDRDELPGSPPAALARSGANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MG67</accession>
    <name>A0A3N6MG67_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92926">
        <property type="protein sequence ID" value="RQG92926"/>
        <property type="gene ID" value="EA462_01510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="425" mass="44728" checksum="9415EE788AFAD2AA" modified="2019-02-13" version="1">MADLDSTIARRDSRRQDGFVPFFRRYTKTWVHAVATAGLTAFGTLTFVHRWFVALALASYVVPPAVLYVQQSGDDVGKVSDDTAETATAANEREISADESESDTHDTRDDETDSQDDEPKETDGPSVRWRSVDFDADATLFDVVITERDVAYAVGAGGIVGTDGGTESWSILLEDGPSASANDLWGADATDDGDAVWVAGNSGAVGRLDVGSGRHTDYTAPREITDNILGVAAGGSAGEETVLLITGSGAVIRGRYRDGGPEWNEPLKPGGGSSLSAVVLVDGSTGYCCDTNDGVFATDDGGESFTRIGPAGADGTLEGVAADDRLEPMVCADDGVVRRFDGSTWTPERVVDGSLSGIDHRNGRTVACDTDGGIHERRSDERSKPPSWEHFDTDAAAVLAVSIGPERSVAVGEGGTVLRRTDSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MG75</accession>
    <name>A0A3N6MG75_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_01570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92936">
        <property type="protein sequence ID" value="RQG92936"/>
        <property type="gene ID" value="EA462_01570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="257"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="326"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG92936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="413" mass="44523" checksum="F05CD2A8F2130736" modified="2019-02-13" version="1">MIRSFRIGSLFGIPIKLDLTFLLVLPLFAYLIGLQLGPVIEILNASMGAGIDADSLTAEWWLPYAVGLVAAIGLFVGVVLHELGHSLTAQRYGFPIDSITLWLFGGVAALSEMPEDWRQEFTIAIAGPIVSILVGVVSYALFLVTPVGFDGARFVLAYLAILNVALAGFNMLPAFPMDGGRVLRAFLARSKPYAKATQQAAGVGKFLAILMGLFGLLVSFNIILIGVAFFVYIAASSEAQQVTMKAAFQDVTVSNIMTPVSDLHTVEPDTTIADLLQRMFSERHTGYPVVETSATDEERLIGLVTLSDARTIDPVERDAYTVEDVMTTDLKTISPESDAMTAIERMRENNIGRLLVVEGPNHRSTEYASDPGQHGRGDGDLVGLISRTDLMTAFDIVQKSGAVTPAAHPRTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGD7</accession>
    <name>A0A3N6MGD7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">cas2</name>
        <name evidence="9" type="ORF">EA462_01995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93006">
        <property type="protein sequence ID" value="RQG93006"/>
        <property type="gene ID" value="EA462_01995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG93006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="90" mass="10478" checksum="3D57DF8D5AB031F2" modified="2019-02-13" version="1">MRLAITYDVSDDANRRRVYRTLERYGAWKQYSVFELEISKTDRVELEDQLESQISPSDGDRIRIYRLCSACQDATTDLGDEPPDEQSNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MH38</accession>
    <name>A0A3N6MH38_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine O-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cysE</name>
        <name evidence="5" type="ORF">EA462_02940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93316">
        <property type="protein sequence ID" value="RQG93316"/>
        <property type="gene ID" value="EA462_02940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01172">
        <property type="entry name" value="cysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="170" mass="17900" checksum="AFB0C416F05BBF67" modified="2019-02-13" version="1">MFGRLREDIRAMCDRDPAATGCLEVALCYPGVHAVWGHRVAHWLWNRGLRLAARLFAHVVRLLTGVEIHPAATIGQRVTIDHGMGVVIGETAEVGDDVHMYHGVTLGGDTNERVKRHPTLEDGVTVGANATLLGAITVGSGASVGAGSVLTTDVEPGATVAGVPARRLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MU12</accession>
    <name>A0A3N6MU12_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_10765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88872">
        <property type="protein sequence ID" value="RQG88872"/>
        <property type="gene ID" value="EA462_10765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="118"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="456" mass="49427" checksum="D2A5578B27F3AAB5" modified="2019-02-13" version="1">MSDQPRVEIYTKEDCPYCEKAMDLFDSKGIEYVTHNVTTGKRRFPTDWSEENSREDSDDLFEEMVERADGRKTAPEVFIDDELIGGWDDTSALEETGELDEKLGLETDGDDEVEHRPLLIAGTGIAGLTAAIYAGRSNNDPLVIEGDEPGGQLTLTTDVANYPGFPEGISGPELVNNMKAQARRFGAELENGIVDSVDASSRPFRVELTNGDVYTADAIIAASGASARTLGIPGEDELMGYGLSTCATCDGAFFRDEDMLVVGGGDAAMEEATFLTKFADTVYIAHRREEFRAEDYWVDRVHEKVEAGEIEIMKNTEVIEIHGSQQAGVDHVTLVQNERGHPTDRLDDPETEEFEFDVGAVFFAIGHTPNTEYLEGTGVEMDADGYLKTQGGDGGGQTETGVPGIFGAGDVVDYHYQQAVTAAGMGSKAALDADEYIEERERAAAEGETEVAAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUA6</accession>
    <name>A0A3N6MUA6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S8 and S53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_11320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88972">
        <property type="protein sequence ID" value="RQG88972"/>
        <property type="gene ID" value="EA462_11320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07477">
        <property type="entry name" value="Peptidases_S8_Subtilisin_subset"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034202">
        <property type="entry name" value="Subtilisin_Carlsberg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="153"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="431" mass="45421" checksum="E6DC800BD4AAD4A2" modified="2019-02-13" version="1">MEHDSSRVTTPNRRTVLQTIGAGGLALGGIAGTSGSAAAGSDENWTELSVGDHDQRYNVGYKNGDGAKTAKDVATTVYYDIDPLDALTIESDLDGLQTLEENDDIEYVEVDRQLEVELPPQEVEVQQETNGQTVPWGIERIGARDVHEMGITGDDVDVCVLDTGIDPSHEDLAANLGDGAAYTECQGDLVPWECEEPWSDDRESGHGTHVAGTVGALDNDLGVVGVGPDVTLHAVKVLDQNGVGFHSDIANGLAFAGFFEFDVANMSLGGVDTELKRAGVEYAHEQGVLLVASAQNEGAPVLYPAAYDEVIAVSATTPDDTLAWFSNRGPEVELAAPGVDVLSTVPQDGYAAYEGTSMAAPHVAGAGAIIMSLGYSASETREILNATAEDISLPSEHQGSGLVDVATAVELALEEQREKEEKKREKKGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUF5</accession>
    <name>A0A3N6MUF5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89022">
        <property type="protein sequence ID" value="RQG89022"/>
        <property type="gene ID" value="EA462_11610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="97" mass="10983" checksum="2AEC183BFB6EC6F3" modified="2019-02-13" version="1">MNHQKILLIAYYLVYIMSESETEKSILKWFVLPATLTFFLVNLFQISPILSVWTTSVIGGGNILWVILIPTYSLLLAVLVGFCGLHFPPPDQCERPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWE4</accession>
    <name>A0A3N6MWE4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_07220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89802">
        <property type="protein sequence ID" value="RQG89802"/>
        <property type="gene ID" value="EA462_07220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016116">
        <property type="term" value="P:carotenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045892">
        <property type="entry name" value="CrtISO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313">
        <property type="entry name" value="PTHR46313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="492" mass="54378" checksum="34A4765DCB76A057" modified="2019-02-13" version="1">MTGNRFDVIIVGGGVAGMSTAARLQSKGRSTLVLEQHDHIGGCAGYYRSGEFTFDVGATTLVDFHLDGVGGQLLDEIGFEYSDITIQDAYSVWLPDRTVTLYRDQEKWRRERREKLGNEDRHLEFYKFLDEMSETLWQMTRQDIKMPIQSVQDVIQNVRAVGVTNIPLVRYLQWTMADALRQYDVYDDTPLRKTVAMLVEDTVHSTLDNAPLLNSILGITIRRAGIGRATGGMYGFWGAFTEQYHTLGGTIKTGQTVTDITGTDGAYTVSTQDKQYTARQVVSAVPINLTKSIASSIVGNALDEHIEMLRAHEGGAAVVFLGVPETEVDDHDITHHQILTAYDEPLGDGNNMFVTVSAPEDTVSAPEGYRAVMLSTHCDVEFWQELDDETYARRKDAIGQRLISHARTVYPDLATDPVVYDIGTPVTYESFTNRPRGATGGYRQTIQNSNQHAVPQDIGVDGFYLAGDTTWPGLGTVACIKGSKIAADLVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWT8</accession>
    <name>A0A3N6MWT8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89952">
        <property type="protein sequence ID" value="RQG89952"/>
        <property type="gene ID" value="EA462_08055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="6755" checksum="710B357F0F723FC0" modified="2019-02-13" version="1">MDETTVRLLCPECAKDWQVSPSELPESTGMFHCPNCHASRRTGEFMRTDRDLQTLKQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXW2</accession>
    <name>A0A3N6MXW2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90382">
        <property type="protein sequence ID" value="RQG90382"/>
        <property type="gene ID" value="EA462_09540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="131" mass="14151" checksum="DEF015A86CC18B3B" modified="2019-02-13" version="1">MDVGGVVVPLGIVVAYGTAIGVFIDLDHFVIARLRTGDWNALRFCVTHPSAAVVDQDRLFDRGDVGLLSRLLSHLLITVAVVSVVAVESTPLGLITGVVLYVHIVTDVAWDIRRLPDDLEDAPEDVLNALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MZX9</accession>
    <name>A0A3N6MZX9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91172">
        <property type="protein sequence ID" value="RQG91172"/>
        <property type="gene ID" value="EA462_04045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="62" mass="7207" checksum="CA52F75530A97E0C" modified="2019-02-13" version="1">MHLMFAVAVVSDADDSRIGRPNNVHFVEFESLCLVCSLNDRFVWSVVYHQMRLFNVNSFSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0I7</accession>
    <name>A0A3N6N0I7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Twin-arginine translocation signal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91412">
        <property type="protein sequence ID" value="RQG91412"/>
        <property type="gene ID" value="EA462_05420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="1">
        <location>
            <begin position="90"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="157" mass="16657" checksum="7CFAAAFCE6DC832D" modified="2019-02-13" version="1">MTTFNGNRRTFLKAAGAATATALVAGCSDNGNGNGNGNGNGNGDGEGVEIEPGTEILFDGQMSGWEGLEPAEIEGDVNPTLILQEGESYEIGWTEGDDNFHNIEIRDDGGDVVDDLETEEVDDPDDDQILEFEASGEMAEYVCDPHPNSMVGELIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N400</accession>
    <name>A0A3N6N400_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92892">
        <property type="protein sequence ID" value="RQG92892"/>
        <property type="gene ID" value="EA462_01335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="61" mass="6591" checksum="C56D2D9B5C93857F" modified="2019-02-13" version="1">MSDGERQRTIAKCRSCSSAYAVDVWDDGTIRPIGRTNCDCGLNDFEIIGDSSDTIALYGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NU08</accession>
    <name>A0A3N6NU08_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_17100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86186">
        <property type="protein sequence ID" value="RQG86186"/>
        <property type="gene ID" value="EA462_17100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="174" mass="19018" checksum="EE68EFA720AB4E36" modified="2019-02-13" version="1">MTDYDAVVYDLDGTLVELDVDWNAVAADVLAVYDSADVEPPTTDIWDLLERAPEFDLETEAHSAVAAHEREGAPTSPRLAHADDLEERSVPVGVCSLNCETACRIALDRHGLDEAVDIVVGRDTVARQKPYPEPLLEAVDKLDAVPERTLFIGDSPSDELTAERAGTAFEYVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVM5</accession>
    <name>A0A3N6NVM5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxyacyl-CoA dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_13650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87902">
        <property type="protein sequence ID" value="RQG87902"/>
        <property type="gene ID" value="EA462_13650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="184"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="291" mass="31264" checksum="E8154739B8A29054" modified="2019-02-13" version="1">MDVTVLGAGTMGHGIAQVSAMGGHDVTIRDIEQSFVDDGLAAIENNLEGGVARDKLTREEADATLDRIDGSVDLAEAVTGADLVIEAIPEQMDLKVDTVETVEENVSTDAIIASNTSSLSVTEIASAADRPERVIGLHFFNPVHIMALVEIVVAEQTGDETVAFAHEFVEGIEKVPVEVIDTPGFASSRLGVALGVEAIRMVEEGVASPRDIDTAMELGYNHPMGPLELTDVVGLDVRLEILEYLREELGERFKPPQELKRKVRAGNLGKKSGEGFYVWEDGEIVDEEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVM9</accession>
    <name>A0A3N6NVM9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87912">
        <property type="protein sequence ID" value="RQG87912"/>
        <property type="gene ID" value="EA462_13700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12681">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="128" mass="14114" checksum="A0F1421F55B272F7" modified="2019-02-13" version="1">MTPTLSQVYLMVTDLERSREFYETVFDLPIAETGSQSVAFETGRCELKLEQQFDDETLSAFGLSPPGDSRGDGAIAVLEVDDVDAVYERATEAGATTPFGPADVEWGRRILLVEDPDGYVFEVSRPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVX0</accession>
    <name>A0A3N6NVX0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88052">
        <property type="protein sequence ID" value="RQG88052"/>
        <property type="gene ID" value="EA462_14475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="164" mass="17704" checksum="82DD8DEFF65AD406" modified="2019-02-13" version="1">MTELTLTVNDEQQTIDVDPSKPLVDVLRDDLGLTGTKKGCSTGVCGACTVRIDDEPRKACMHIAGMVDGKSIETIETLSDGDDLHPVQEAFLEEFSLQCGFCTPGFIMSAVALLEENPDPTDEEIETALHGNTCRCTGYDMIFEGVKRAANEMNNESAAQPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWC5</accession>
    <name>A0A3N6NWC5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88829">
        <property type="protein sequence ID" value="RQG88829"/>
        <property type="gene ID" value="EA462_10530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="171" mass="18035" checksum="3693D79244CA79C4" modified="2019-02-13" version="1">MKRRSFTLGIGSVAIAILGVIGSSALSRVTTGRATTVQQTGDGTAYLGLAPSDDPNGEYATTNETTGAFRLFIDTVNPEGVTELDDVFVITNNGTQPVDVWLEPDGENPESIAFTDAETETDLTDADEPVTISVGESITTDIFVDTTDHGEETEIIDTLIVNANIGSMSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWT6</accession>
    <name>A0A3N6NWT6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterio-opsin activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_11705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89039">
        <property type="protein sequence ID" value="RQG89039"/>
        <property type="gene ID" value="EA462_11705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAT" evidence="4">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="219" mass="24513" checksum="0018D267C378F2C5" modified="2019-02-13" version="1">MSTIAELRFPVPDTTLETAFEYAPDATFELESSVSKTRPCLWVSGVDRDLAVASFDADPTVEACELVVETNSRLLFDVTFGDGAGIDQLCDPLLSDGGSLLEAWATDGWWQVRVRFPDRDALCNAYDRLVDRDINADLRRVTDVTDTAEPETRLTPQQREALEAALEYGYFEIPRRISMEELAAELGISHQALSERFRRAYETLVDEELQPVGERSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX71</accession>
    <name>A0A3N6NX71_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalt-precorrin-2 C(20)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_12865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89249">
        <property type="protein sequence ID" value="RQG89249"/>
        <property type="gene ID" value="EA462_12865"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="298" mass="31827" checksum="A17F276A950CDB47" modified="2019-02-13" version="1">MSSDADPAGENASTDATPGGTPDDHGTLSVVGIGPGLPTHMTRRAKEVIESAEVVIASSLYQKFLRADGTLAPKAETGEDGIAVRDDGVEQEIVRSTMGRQIELARAAFDHVREGKDVAHVSGGDPSVYGKSDLIFKMAAEENATDVPIEIVPGLTAALGGSANVGAPLCNDFCTISLSDKWRGWDEIEEKLRAAAISGFVIVLYNCWRNYERAVDIVREERTDDAFVAIVNDAGREAAGRNGESQFITTLGEAGEHDDKVSGMGTSLIVGNHETETWSNDDRTYLVTPRGGRDVDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYD4</accession>
    <name>A0A3N6NYD4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89829">
        <property type="protein sequence ID" value="RQG89829"/>
        <property type="gene ID" value="EA462_07370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039065">
        <property type="entry name" value="AcoX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011386">
        <property type="entry name" value="Put_ATP-NAD_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40697">
        <property type="entry name" value="PTHR40697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016907">
        <property type="entry name" value="Kin_ATP-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="378" mass="39813" checksum="B51965168C00B32A" modified="2019-02-13" version="1">MDSLGVVVNPIAGMGGRVGLKGTDGTLEEARQRGAEPRAPERARQALRSLYRRTPDLTVYTAAAVMGEDAARDAGYEPEVVYTASSLENRSERTGHDSSGLEPDEAGTTADDTRGAVGAFLEQGVDLVLFVGGDGTAVDVASVLTDTADDKSQVPMLGVPAGVKIYSSVFAVTPSDAGRIAAEFDRVESREVTDIDEAAYRDGEVRTQLRAVVSVPVAPAVQSSKQISGGSVDSLAAGFAREIDSSRTYVFGPGGTVGAIETELEIEPSPLGVDVWRDGEVLARDAAESEILEVLEDPVTIIVSPIGGQGFVFGRGNHQISPAVIGRADEIEVVASGEKLDGIDVLRVDTDDGEIDEALRGWLRVRTGRFTTRLVKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYM7</accession>
    <name>A0A3N6NYM7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86162">
        <property type="protein sequence ID" value="RQG86162"/>
        <property type="gene ID" value="EA462_16965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="110" mass="12261" checksum="AAE4006C15C38E84" modified="2019-02-13" version="1">MTGWIYIRSRWLRIPFILAGFLVFLAAVAVVVVAVSTVAYTAFGLLLGVPMTDVIATLSIHQIASERATDPLSWIAAFLVSIVLLPCFDWYQRWVSRALRTTDSGAKMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYN1</accession>
    <name>A0A3N6NYN1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome oxidase assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89959">
        <property type="protein sequence ID" value="RQG89959"/>
        <property type="gene ID" value="EA462_08095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="294" mass="31934" checksum="C4F2FE9C3FD996A1" modified="2019-02-13" version="1">MSTDNSLSRTVARPIIARFGFPQLLATTLVLVGATILLGVAAKATGSGLACEANWPQCDAGPYNLFPANLPSFYEWFHRFVAMFAGFAIIGSALAAWRIPSVDKRVATLVILGTILTPIQIVLGRETVLQYEMTILSLHFWTAVLIFVLFVVATAFVWKPRLDRTHVTGALVLTAASLPLHVALSPLALTDITEYSPTVQMIQYAVTLALLAGVIVAVMVGRWRFEDERVRLLLSVAAGLALIVVFLGRRAVMTFNPALDYLYVVASAVLFVVCLGGIWLSRRDPSDSSNSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ33</accession>
    <name>A0A3N6NZ33_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90149">
        <property type="protein sequence ID" value="RQG90149"/>
        <property type="gene ID" value="EA462_09170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="6901" checksum="04B137F9C1098370" modified="2019-02-13" version="1">MSRVVLRTVDSAISAERTDAFVTNQPSRTLGRVRSKESSPGRASLRSVDLEPGWGSIVTVEGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZE1</accession>
    <name>A0A3N6NZE1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
                <ecNumber evidence="16">2.3.1.234</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">tRNA threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="16">t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Serine/threonine-protein kinase Bud32</fullName>
                <ecNumber evidence="16">2.7.11.1</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="18" type="ORF">EA462_14700</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 16">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="16"/>
    <dbReference type="EC" id="2.7.11.1" evidence="16"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86906">
        <property type="protein sequence ID" value="RQG86906"/>
        <property type="gene ID" value="EA462_14700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01447">
        <property type="entry name" value="Kae1_Bud32_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022449">
        <property type="entry name" value="Kae1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009220">
        <property type="entry name" value="tRNA_threonyl_synthase/kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="PTHR11735:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036401">
        <property type="entry name" value="Gcp_STYKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 16" id="KW-0408">Iron</keyword>
    <keyword evidence="11 16 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="17">
        <location>
            <begin position="34"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Kae1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Threonylcarbamoyl-AMP binding" evidence="16">
        <location>
            <begin position="142"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for kinase activity" evidence="16">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>L-threonylcarbamoyladenylate</name>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>L-threonylcarbamoyladenylate</name>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>L-threonylcarbamoyladenylate</name>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>L-threonylcarbamoyladenylate</name>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="353"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RQG86906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="563" mass="61382" checksum="8EAC00FFC1EEC569" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZX3</accession>
    <name>A0A3N6NZX3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWIM zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_15920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87146">
        <property type="protein sequence ID" value="RQG87146"/>
        <property type="gene ID" value="EA462_15920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="567" mass="63509" checksum="8BEED51FB141B3E6" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0H8</accession>
    <name>A0A3N6P0H8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine pyrophosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87988">
        <property type="protein sequence ID" value="RQG87988"/>
        <property type="gene ID" value="EA462_14110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="203"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="420"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="564" mass="60004" checksum="E9F04D397D1E8FF7" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1N5</accession>
    <name>A0A3N6P1N5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_05510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91429">
        <property type="protein sequence ID" value="RQG91429"/>
        <property type="gene ID" value="EA462_05510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="140"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="375" mass="40219" checksum="4679531B8982FC5C" modified="2019-02-13" version="1">MNRGAIGIGIVGLGGMGTLHARSLSDLGAEIVAGADLVESKREQFETEFDATTYETHEGLVVDGDVDAVVVTTPNRFHEPITVDALEAGCDVLVEKPLAHTLESAERIVATAAAAEGFCMVGFHNRHAASMAIFDEYDARGRFGELTHVEANYVRRRGIPGPGSWFTDPDLAGGGALLDIGVHALDLALYALDFPEITEVSGVTRTTFGTRETYADPDGFGDNWDAQAETYEVDDSVSAFIRFADGQTISLESAWATNREESMEFRVRGTEAGAKFDIGGTELNIIEASTAGCDHYADVHLEGDPTVTGHVTQDEAFLDAIAAGGEPETNTVDEALVVQRVIDAIYRSSETGRTVQFDDSFPESERTTTPKSLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P217</accession>
    <name>A0A3N6P217_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89175">
        <property type="protein sequence ID" value="RQG89175"/>
        <property type="gene ID" value="EA462_12475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="144"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="393" mass="44849" checksum="7D4AF186E6148A23" modified="2019-02-13" version="1">MANSPRAKLKVRREKLEGHIEKGEIDPDTGNAIRELLDAYDENKVMVTKPKGESHRTPQTLMAWLYRLMVFAQYRNLTESEADDINRDVQKMHSGDHPHVQDKGLKKGTLRAYQAAVRKFYGFYDFGVDPNDIPLFDKEETSVEPNDMLTKDEIHEAREVIDNPRDLLVYDLLLYTGQRREALRTIRIKDVKPQEGTYRLNPEVDGLKGATERNGNRPLLGAKATVQDWINNYHPDPSNPENYLITARPGYSRPDPTKPVSGETIRQVMLKVKEKTNITKPMHPHAMRHNHVTIAKRDYNIPDDTIKYLIGHSADSTVMESTYAHLSGDDHVQRAEEAFGIREPEEESAFTPEVCHVCNQPLEPNAKACSNCGTVYTPDAQATQEQIQEDMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P279</accession>
    <name>A0A3N6P279_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Precorrin isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_12895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89255">
        <property type="protein sequence ID" value="RQG89255"/>
        <property type="gene ID" value="EA462_12895"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="4">
        <location>
            <begin position="22"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="239" mass="25599" checksum="3F5BA652935E278C" modified="2019-02-13" version="1">MSDRKYEREYADLGATTRSAMDIAQTSMDIVRQFVPDETLADRIRQKSVHSMGDIEFQHLISFTGCDRQGDDDDAPVRAGARAVLAEAPIVTDITMSKAGITSRGHGCRKRTAIGNGSELAEETGMTRTAASVLELDKRGVYDGAIATIGNAPTAAFALADCIENGTRPEVVVATPVGFVKAEESRERIRDVSEAYDVPAITNVGRRGGSGLAAALTNELIHVASDVRTGELELEEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P2B8</accession>
    <name>A0A3N6P2B8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PqqD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89295">
        <property type="protein sequence ID" value="RQG89295"/>
        <property type="gene ID" value="EA462_12765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="96" mass="10786" checksum="BD76688BE2837CC4" modified="2019-02-13" version="1">MLSDSMTVVATDDHLATSIECETVILQLESGTYYGLNEVASHLWDLLQEPRTVAELHDELCTTYDVSAERCRRDVESTLTNLADIDLVELEPERSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3Y0</accession>
    <name>A0A3N6P3Y0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_08735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90075">
        <property type="protein sequence ID" value="RQG90075"/>
        <property type="gene ID" value="EA462_08735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="330"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="409" mass="43497" checksum="0F2A8A572CA2B587" modified="2019-02-13" version="1">MTVTISDIRRAQNRCDDDDVVRVTPIETSRTLDSEVGADVRLKMEHLQRTGSFKTRGAYNKLTKLTESGTDRTDVIAASAGNHAQGVALAATKAGLDSTIVMPKNAPQAKIDATKGYGGTVDLHGKTFRDAMGYAKSIADDDSVFVHAYDDPDIVAGQGTLGLEIIEQVPDVDTVIVPIGGGGLIGGIATAIGERSPETRIIGVQADGAATVPESLEAGAPRTRESVQTIADGIATGGISDLTYQLITEYVDDVITVTDTEIAESVLFLLERTKQMVEGAGAISVAALRSGQLDVEGEVVVPLLCGGNLSMTDLQTVLTHGLTHRDQLVRLRVQIVDQPGEMNRISEAIGDHGANISDVSHERSAKDLDVGDAYLQFRIETSGSDQTERIVESIREMGYDVRTCGEGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P479</accession>
    <name>A0A3N6P479_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90165">
        <property type="protein sequence ID" value="RQG90165"/>
        <property type="gene ID" value="EA462_09255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="2">
        <location>
            <begin position="29"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="231" mass="24261" checksum="E85D6C35A2453B67" modified="2019-02-13" version="1">MTAGSAAGPDDVEGPHQDQPLVAAGTPLEESEAAVVLVHGRGATARSILGMGEEIHEDGVALLAPQAARNEWYPNSFLAPVESNEPGRTSGLRAIADAIDEAVTAGVPTDRVVVLGFSQGACLASEFVARNPRRYGGIVALSGGLIGESVDVEEYAHGTENDATFEGMPAFLGCSDVDPHIPKERVHETTRVLEALSADVTERIYEGMGHGVNEDELAFVSGMIERLVTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4A8</accession>
    <name>A0A3N6P4A8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90205">
        <property type="protein sequence ID" value="RQG90205"/>
        <property type="gene ID" value="EA462_09465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="448" mass="49390" checksum="08DC4883F27895EB" modified="2019-02-13" version="1">MSDDEANGDGSAGDEPADSEQRDVDLEGIRDRLEGFQSDLEGLTADLEAAETEADLDVVEADIDEFRAEIEDVEVPEPPETDEDEDDEDDEQTPEEALEETYDGIESDVSDLEDDLEDQRGPYAEDVVDEIDGTTSTITDTRWTTEGDEELIEGVESFLADVTELLDESVSVDEGDDVPERLAATLEECADAVEAVDLDADEDAATIAGLLEATDDLESDVDEATAWTDLEVREQLRREGFYDVLDHVKDFPPEWHALKVHEKRGNVDMILLAYESLGSDFMEEHCLEALERMGPEEAMEPMLQKANRRDTTAMSILGKIGVTDEEVVETLLDYVDSNPDLQKPAFRALGEVGAEDAVQPIANQLEADNPDVRSWAARALGLIGDTRAIEPLSDRLETDEEDRVRASAAWALNQLGTQTALEIVAEYADDRAYLVQAEAERADLEPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4I9</accession>
    <name>A0A3N6P4I9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome assembly factor SBDS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_10030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90305">
        <property type="protein sequence ID" value="RQG90305"/>
        <property type="gene ID" value="EA462_10030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="PTHR10927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="SSF109728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="SSF89895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBDS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="SBDS_C" evidence="3">
        <location>
            <begin position="101"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="241" mass="27005" checksum="19D6016FFFCDBD2A" modified="2019-02-13" version="1">MISLDEAVTARLESHGARFEVLIDPDAALAIKRDEFEGDLEEVIAAEDVFEDASRGDRPAETDLETVFETTDPIEIIPEVIKEGEIQITADQRREMQEQKRKQLIDTIARNAINPQMDDAPHPPERIENALEEAGFTVDAMEPVQSQVDDALDALRPVIPIRFEEVTIAVQIPAEYAGSAQANVRQFGDLEREEWQPDGSWIGAVTFPAGMQNDFYDVVNEHSSGEAETQMVKDKDDLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHY3</accession>
    <name>A0A3N6LHY3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactonate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.6" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86669">
        <property type="protein sequence ID" value="RQG86669"/>
        <property type="gene ID" value="EA462_16125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="126"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="42872" checksum="69CF97FD24D47244" modified="2019-02-13" version="1">MKITGYELFEVPPRWLFLKIETDDGVVGWGEPIVEGRAQTVRTAVEEVMNSYLVGKDPHTIEDHWQAMYRGCFYRGGPVLMSAIAGIDQALWDIKGKSFDVPVYELLGGRTRDRIRVYQWIGGDRVTEIGAEAKQLADAGYTALKMDASNQMRHLEPPAAVDEITDRVQHVREVVGDEMDIVVDFRGRISKSLAKRVIAALEEFDLLFVEEPLLPENLEYLPTLAGRTNVPMATGERLYSRWDFKPLFRRGGIDVIQPDVSHAGGISELVRIAAMAETHDVAVAPNCPLGPIALAASLQVSTHIPNLLVQDHGFDIYPAPKSAADHYLHDSSVFEFVDGYLSLLEKPGLGLEIDESAIRKRSRQDLDWSNPIWRHEDGTIAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIE5</accession>
    <name>A0A3N6LIE5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Archaeal Rqc2 homolog aRqcH</fullName>
            <shortName evidence="1">aRqcH</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rqcH</name>
        <name evidence="4" type="ORF">EA462_14875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86939">
        <property type="protein sequence ID" value="RQG86939"/>
        <property type="gene ID" value="EA462_14875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00844_A">
        <property type="entry name" value="RqcH_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043681">
        <property type="entry name" value="RqcH_archaeal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="3">
        <location>
            <begin position="518"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="728" mass="81674" checksum="34BC397F3368575B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LII6</accession>
    <name>A0A3N6LII6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemL</name>
        <name evidence="9" type="ORF">EA462_15355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87019">
        <property type="protein sequence ID" value="RQG87019"/>
        <property type="gene ID" value="EA462_15355"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG87019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="448" mass="48614" checksum="76370B71AA645708" modified="2019-02-13" version="1">MNHDNSRTLYDRALSVMPGGVNSAVRAAIEPYPFFVRRGAGGHVVDADGNRYIDWVMGLGPLLLGHDLPESVRAGIQRNASEGPMYGTPTEIEVDLAEFVVRHVPSVEKIRFVNSGTEATVSAVRLARGYTGRNKIVVMHGGYHGAQESTLVGGDAENPSPSSAGIPQSFAEHTVPVPFNDEDAIRDVFDAHGDDIAAVLTEPILGNYGIVHPEEGYHEFLRQITDEHGSLLIFDEVITGFRVGGLGCAQSEFGVTPDLTTFGKIIGGGFPVGAIGGRADIVEHFAPTGDVFQAGTFSGHPVTMAAGLETLQFAAANDVYDHVNGLGDRLRRGLSDIVADQAPSYTVTGTDSMFKVIFTRDGPGKESLEEQCDAGCRQHPTCPRYDYCPKNAADVKDAETERWRRIFWGEMKDQGIFLSQNQFECQFVSYGHTDDDVEETLEAYKDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIM7</accession>
    <name>A0A3N6LIM7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium:calcium antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_12945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87776">
        <property type="protein sequence ID" value="RQG87776"/>
        <property type="gene ID" value="EA462_12945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00367">
        <property type="entry name" value="TIGR00367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="9"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="172"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="313" mass="32783" checksum="2DB8DD266F5B6B83" modified="2019-02-13" version="1">MSEFVVNGIVLVLGLVFLYAGAELLVAGASRLALSFGLRVATVGVTVVAFATTAPELFVVTVGALSVSTDIGLGAIIGSNVANIGLVLGLTALIRPLSVSPTVLRRHVPFMVFAAALLFVFSLDGRIDRFEGTLFLLVLSGFTVYLLYYIQTDPPALTEYSISDAGSNAHNLALVGAGMLTLVLGSRWLIDGGRGLLSTMGFSDLFIGITVIAFGTSLPELAASVVGAIRGETGFSIGNVIGSNIYNILAVIGITSLIVPITVSPATLQFELVVLVIFTLVLVGMMIRNRELTRVDGAILVSGYLVFLYLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIU8</accession>
    <name>A0A3N6LIU8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87906">
        <property type="protein sequence ID" value="RQG87906"/>
        <property type="gene ID" value="EA462_13670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="109"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="359" mass="38643" checksum="E79BE8042D61315D" modified="2019-02-13" version="1">MVAYPNRRTVLKSTVGAGLVGVAGCLGDENGETDDGETDDGTSDDDGGATDDGTGDEGDVAFPDEIQIGVPSPTEPVYAFPIYGDFQSQLDEHGTSLERTMFNGFTPMVAALMSGEIDFGYLTVEGIVGAINEGFPIVAFSGFLDEYVFVMIASPEIDTWEDLEGGRAATHSPNSMSTVVGEVMIDEELGSDAVDLINILGATDRLAALEADEVDAAIVPYSAALNAEDEGIGSILAAPWEYEKLQSNLASAWITLEDTYDENTDLYRTMADELSVSYEATYDGDLSEVTEQALAGGGEVFPDYGQDIWEQSLETVREIDVWPRDGDIPTENLERSQDLLVETGILEEDDRIDDGFIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ36</accession>
    <name>A0A3N6LJ36_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88066">
        <property type="protein sequence ID" value="RQG88066"/>
        <property type="gene ID" value="EA462_14550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="169" mass="18495" checksum="3302520A3C9B9AE1" modified="2019-02-13" version="1">MSIENTEVVDESEHRTIELSVNGDTHQVRVKPNELLLNVLREKLHLTGSKYACGTGECRACSVLVDGEPTLSCLQLAITAEGKEITTVEGISDGRTLHEIQQSFLDTGASQCGYCTPGFVVMTKKLLEDNPSPTEEEIRDHLKGNICRCTGYNNIIDAVKKAAEETEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJK8</accession>
    <name>A0A3N6LJK8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88903">
        <property type="protein sequence ID" value="RQG88903"/>
        <property type="gene ID" value="EA462_10945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="124" mass="13656" checksum="2E7415BF1D82C490" modified="2019-02-13" version="1">MDRPGDGDDRILVDPAEDGEDAALDDPVFDRSLLAHRESPPVVLARFSRRTERRLESRVVDGNRVITTPFVTPMQEIYSLTKNSRSLGPAIVRPTAGTPVVATREPESIASSLEWPLEASYGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJT7</accession>
    <name>A0A3N6LJT7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88818">
        <property type="protein sequence ID" value="RQG88818"/>
        <property type="gene ID" value="EA462_10465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="240" mass="26231" checksum="A37FED2E05185CDF" modified="2019-02-13" version="1">MTDELESEVDGLGDVAERRDDVAARVRTHAGQIARELAVLQGGDYGQETFSTDAGSWTLKYEAGDVQYLRFDPKSGSETYVVSSKQPPEPEPLATAMANYDAFVAAYNEYVASFDGLFDGVSTEFPPIESTAELAAERDRIVDRIRTVADRMAGELYRYDGEYGTYAATVSGTRWELKWDGDVASYLRVGGSDGTYLVSQYGPPAAPEVRRLVDDVGAFVASFNDHVDDLEADLSTVSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK32</accession>
    <name>A0A3N6LK32_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88928">
        <property type="protein sequence ID" value="RQG88928"/>
        <property type="gene ID" value="EA462_11075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="121" mass="12745" checksum="0C0FCE26263FA9EE" modified="2019-02-13" version="1">MSHVDISERAFGAIFLGIVVYFGLVIYGSFANEPLATLAAEFVFGVIAIGLGTLLYAVANATRSVLFGAAIALVAGGVLQFGYLLSHVLAVQQASIIDHASSIAVFVGIGLYVYAVWFDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKE7</accession>
    <name>A0A3N6LKE7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89263">
        <property type="protein sequence ID" value="RQG89263"/>
        <property type="gene ID" value="EA462_10485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="9139" checksum="8FFDEF59A946AF15" modified="2019-02-13" version="1">MSLAIVDAVATRRGVDPLSLPPLYRYVDPDALDRLITDVPRSATPFRLEFTYDGHDVVVERAADLTVAVDGSTVDDGASSFNTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKK7</accession>
    <name>A0A3N6LKK7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="5">BCAT</shortName>
            <ecNumber evidence="5">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ilvE</name>
        <name evidence="6" type="ORF">EA462_12595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89198">
        <property type="protein sequence ID" value="RQG89198"/>
        <property type="gene ID" value="EA462_12595"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="309" mass="34612" checksum="CC04955AED032954" modified="2019-02-13" version="1">MGFDEMDVDTIWMDGEFVDWDDAQVHVLTHGLHYGSGVFEGARCYDTEQGPAIFRWEEHLERLYQSAKPYEMEIDHTMAELTDATLELIHRQELPSCYIRPIAFYGYNSLGVSPADCPTKTVIAVWPWGAYLGEEALEQGIDVMISSWRKHASSQIPTNAKTTGLYVNSMLAGEEARRNGYAEAIVLNKEGNVAEGPGENIFLVRDGEIYTPGLSESILDGITRDTVITLAEDLGYTVHDNVSISRGELNTADELFFTGSAAEVTPIRKINNVVIGDGSRGPITEDVQSRFFEVVERQTDEYDEWFTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKR5</accession>
    <name>A0A3N6LKR5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89268">
        <property type="protein sequence ID" value="RQG89268"/>
        <property type="gene ID" value="EA462_10895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="188" mass="19792" checksum="7090051E3FEFC12B" modified="2019-02-13" version="1">MMATTHVFAGLVLAAIVALIAPQFAAVAAFAAILGGLFPDLDVVADHRKTLHYPVYYSALAVPTLLIAVVVPGPATVALAVFVLAAAGHSVADCVGGSHELKPWQAGSNRAVYSHYHGQWLEPRRWIGYDGSPGDLALSAVLAVPALFVFDGTVQVLVVGMLVVSIAYATLRRPVAAGVDWLVRRENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLM2</accession>
    <name>A0A3N6LLM2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase family protein molybdopterin-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88050">
        <property type="protein sequence ID" value="RQG88050"/>
        <property type="gene ID" value="EA462_14465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="773" mass="83096" checksum="75BED3F6B4D63116" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLR1</accession>
    <name>A0A3N6LLR1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate uptake regulator PhoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89828">
        <property type="protein sequence ID" value="RQG89828"/>
        <property type="gene ID" value="EA462_07365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="343" mass="38167" checksum="27DAE687A0646A96" modified="2019-02-13" version="1">METRKVQRLGPSTLAMTLPAAWASEHDVEKGDEVSLRTSGKGTLTVMPESASSEETEAIIHTDDLDASAVERAIVAQYVLGRRVIRIEREDGALESAHINAVYQAETQLMGLGVIEETPENIAIRCSVDPEDFTLDNLLERLERTGQTMRGEGIKALAHGNPDLAQRALNRERQANKIFVLLLRLIFTAYQNPNLARAVGLDSGFPLIGYRSIAKNLELTADNGEDIADIVIETEGHTLDVDNSVMRDIRELNDLVDEITSLAVESAVERDYDKSNEVRRLFHEISDREKEILADLPEMPNTELLRVREVLVSLQQTAQYAMRNAEIAANLALNEESEHTTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM59</accession>
    <name>A0A3N6LM59_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90163">
        <property type="protein sequence ID" value="RQG90163"/>
        <property type="gene ID" value="EA462_09245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="138" mass="14703" checksum="078B9DF0791F3366" modified="2019-02-13" version="1">MAILVAYDGSEPAQEAVEHAVRNYPGEEIVLLRVVEAAGGSTGAGMNLAREFLKERRTEISESIDEDVAEIAADDDVEFRTETAVGDPARAIVSFAEDHDIDHIVVGNHGRSGVSRVLLGSVAEGIVRRAPAPVTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMI4</accession>
    <name>A0A3N6LMI4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="2 6">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purM</name>
        <name evidence="9" type="ORF">EA462_09650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="2 6"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90238">
        <property type="protein sequence ID" value="RQG90238"/>
        <property type="gene ID" value="EA462_09650"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="58"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="8">
        <location>
            <begin position="172"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG90238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="333" mass="35281" checksum="AFF80088386151DF" modified="2019-02-13" version="1">MTDSADDGREGDGDRLTYAESGVDIEASEDATAALLEAFGSDLRTEYAGVIDIGNRYLALATDGVGTKLLVAEAIGDFSTIGIDCIAMNVNDLVAAGVEPVGFVDYLAIDEPDEALTNQIGEGLAVGLEQADLTMLGGETAVMPEVVEGFDLAGTCVGLATKDEIFAGKANEGDALVGFPSNGIHSNGLTLAREAVTRNHDYTDTFPLDPERTIGEELLRPTRIYTDLLESMRDHGVHAAAHVTGGGLTNLLRMGEFEYVVDDPFPAQPIFEFVQQEGSVTDEEMHRTFNMGTGFVVSLPDAQAEKLAAETDGRIIGRVEEGSSVEIRGLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMI9</accession>
    <name>A0A3N6LMI9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90333">
        <property type="protein sequence ID" value="RQG90333"/>
        <property type="gene ID" value="EA462_10185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043826">
        <property type="entry name" value="DUF5803"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19119">
        <property type="entry name" value="DUF5803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="256" mass="28569" checksum="3FCF5A6D96D82E4B" modified="2019-02-13" version="1">MNRRLILASIVVVVFVGLAGCSMIFGGISDEDLDREAEYDDLRDADSDVVIDIEDGSLLSNSEFRAVYDLNETEEVTMYRSTFYQNQALEIHGVRYWYPNGTELTGSELDVDQSRSSTVVGVPDENGTLAVSGSSGTKTFQLPAFTHGSYEVTLPEGHRTSNFFLGNVNPSGYDREVIDDRERLTWEHVDSTVSLRFYQTRDIPLFLGLVAVVTVLGGTGIAYYYRQVKRLEKQREELGLDVEIEDDDDGPPPGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMP4</accession>
    <name>A0A3N6LMP4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90358">
        <property type="protein sequence ID" value="RQG90358"/>
        <property type="gene ID" value="EA462_07915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="97" mass="10981" checksum="B03866547C3DC52D" modified="2019-02-13" version="1">MTKWLQSGRRRDICVLLAADGELRGQKVKSRLESHYDDRIDPKSFYGSLSALVDAGFVEKRTDGLHDAYALSDAGEQRTSAHYEWMRSCLRADGDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LN63</accession>
    <name>A0A3N6LN63_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87025">
        <property type="protein sequence ID" value="RQG87025"/>
        <property type="gene ID" value="EA462_15395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="544" mass="63773" checksum="A60D5B93935F73C3" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNE0</accession>
    <name>A0A3N6LNE0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87115">
        <property type="protein sequence ID" value="RQG87115"/>
        <property type="gene ID" value="EA462_15940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="266" mass="30332" checksum="3A8F2B17C958F2D7" modified="2019-02-13" version="1">MNVDDETIQDRCTDVVFERGQNYRQEGRIQQIGRFGDLVTADVQGSNLYDVTVELNGNGIDTRCTCPYDGAGDCKHVVAVLLDIVADPPADESAQIEAILDDVSAEDLRVFVRDVLATHQDLRDQFLVQFGDDHKSVEKYREEIDRLFEQDADPTVFTAIDFSRFFEIAKQYRDRNRYLAAATVYRAVFEAVDENFTRIDGAYDHYAQTLQRALDDYVDSVLATDPSPKEFDRYAGVLESQASTDPPINNEQFRRALDNLEDRYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNP3</accession>
    <name>A0A3N6LNP3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87797">
        <property type="protein sequence ID" value="RQG87797"/>
        <property type="gene ID" value="EA462_13065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="69" mass="7748" checksum="2D1309392245A353" modified="2019-02-13" version="1">MQITWASVSVLLYNYGVVLSAAYITMAYGINDRVTILLLAFVFAVFWTVYFEISMVDKIVPSDGSEEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNX7</accession>
    <name>A0A3N6LNX7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6 7">Histidinol dehydrogenase</fullName>
            <shortName evidence="6 7">HDH</shortName>
            <ecNumber evidence="6 7">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 13" type="primary">hisD</name>
        <name evidence="13" type="ORF">EA462_06980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7 12">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="6 7"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89757">
        <property type="protein sequence ID" value="RQG89757"/>
        <property type="gene ID" value="EA462_06980"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="2 6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 11" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6 8">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 8">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10 11">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 10 11">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10 11">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10 11">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG89757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="430" mass="45455" checksum="CAF3203927CFD824" modified="2019-02-13" version="1">MSIEIQDVADLGPNERVAFFDRDAGVEAVRGDVRKIVERVRDEGDVAIREFTGEFDDVAVGNIEITDQCERAYDGLEGDIREAIEDAATNVREFHEAQVPEDWRKAFSEGRELGRRFRPIDRAGVYVPGGSAAYPSSAIMGVVPAVVAGVDHVAVVTPPADEMSPVTLAAIHAAGADVVYSVGGAQAIAGLAYGTETIDRVQKIVGPGNRWVTAAKAEVRGDVEIDFLAGPSELVVVADETADPELVAAELVAQAEHDPNSSVVAVTDDEGMARDIEAAIDEQTNAREREGTIRDALDNDASAVLLARSMSEAILFTEAYAPEHLTIIAHDDESILERIDSAGSVFLGPHTPVAAGDYASGTNHVLPTNGGARVTGGLSVETFLRLTTVQRLSAEGLAGLSGTITTLADAEGLEAHAESVRLRVDDPNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNY8</accession>
    <name>A0A3N6LNY8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinylglutamate desuccinylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_03705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91113">
        <property type="protein sequence ID" value="RQG91113"/>
        <property type="gene ID" value="EA462_03705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043795">
        <property type="entry name" value="N-alpha-Ac-DABA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039012">
        <property type="entry name" value="ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="327" mass="35123" checksum="9F8639B3BEB3F774" modified="2019-02-13" version="1">MSTGTHSVEKLTLARLPSGVELTTTAHTYRGSADGDGPTVYVQAAQHGREVNGTELLRRFHGRIPLESLSGTVIAVPVANPLTFDRISYTTPEAFDSVNPNMNRVWPGDAGGTLHERMAARLWEFVDSADAVVDLHTGSPDMLSHVVYLEGDDRSRSLANAFGNGLVLSEPADDDATDEWHRRDFAGKLRVAASNEGIPSITPELAHNKQIVEPAVEDGVDGLLDVLRHLEMIPGEVAVTGRTLARNYLGQVTTEESGLFRPVPSLGVGESVSQGTTIGTVYDPTTYEPLHEATVERGGLLYAHNQEATVTAGDQLASLATIREEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPR6</accession>
    <name>A0A3N6LPR6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TFIIB-type zinc ribbon-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91493">
        <property type="protein sequence ID" value="RQG91493"/>
        <property type="gene ID" value="EA462_05895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="244" mass="27512" checksum="A90123E216D4B656" modified="2019-02-13" version="1">MKIRGERECQECGTRWSYYETGSIGCPACGSLHSVGTDDRTEHTDQQVAFDLTTVRSDIDDASIDDLADRARDRCREYVRRRGFINAGELCDLDETYLTASELHHVADIVAREFDLEEREELYFLALLRDGDEGERPPPDDVPTTLRAGRGIAYANAVREYRRDVRTWIDVHDRDLAAGERSTLETLGEHVTRIRMLEGDVSPRTAERLIEATRDLADGLRGDELALGRAQDRLAALEGADERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPT7</accession>
    <name>A0A3N6LPT7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90207">
        <property type="protein sequence ID" value="RQG90207"/>
        <property type="gene ID" value="EA462_09475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="55"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="241" mass="26114" checksum="631358C6BF8DB0C6" modified="2019-02-13" version="1">MASNSLLTTVRSMATEDAQEFYGRWSGLYDVIARRTPGIPRLRRRTAAACRLEPGDTVVEMGCGTGANLPYLRERVGPEGTVVGIDFTGPVLERAREATAGYDNVHVVRGDATRLPLAAFPEGTTEIDAILATFVVGMLSDPAGAVDDWCDLVRPGGHVVLANAARSDAWYAPPVNAVFRAIVVLSTPPTTKLRYENEPHLRLDEKIDAAHARLRDRSVAVADETRVFGVVRLTGGRLPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQF4</accession>
    <name>A0A3N6LQF4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89194">
        <property type="protein sequence ID" value="RQG89194"/>
        <property type="gene ID" value="EA462_12575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="220"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="425" mass="45921" checksum="F7891BCCDEC3A9FC" modified="2019-02-13" version="1">MSDVRHRLSELRREFHRHPEPGWREFRTTGRIVSELERIGVDEIAIGRDALETDARMAVPDPEELDPWLNRAREAGVRPDVLEKTADGHTGVVAVLERGEGPRVGLRVDMDGISMRESADPDHRPTAEGFRSEHDGYMHACGHDGHIAIGLGTLEAIKNSEFTGTFVVFFQPAEEISGGGKAMAEGGYLDGVDYLFAAHLGLDNPTGTVVAGIEKPLAMAHLTVTFEGASAHAGKAPNEGANAMQAAATAIQNAYAIPRHSDGMTRVNVGRIEGGTASNVIAEEITLEGEVRGETTALMEYTRTELERVLYAAAEMHDCDVTPRVISESPRVDSDPALRDLVGAVARGLNGVDSVVESVEFGVSEDVTYLMERVQEDGGLASYLLVGTDHPTNHHTPTFDIDDESLEIGVSVLSDAVLECSRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRT9</accession>
    <name>A0A3N6LRT9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0058 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91167">
        <property type="protein sequence ID" value="RQG91167"/>
        <property type="gene ID" value="EA462_04000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002753">
        <property type="entry name" value="UPF0058"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036519">
        <property type="entry name" value="UPF0058_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42203">
        <property type="entry name" value="PTHR42203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01893">
        <property type="entry name" value="UPF0058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140371">
        <property type="entry name" value="SSF140371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="92" mass="10586" checksum="EE6FBD7212FE8900" modified="2019-02-13" version="1">MHKDELLELHEELVVIMEYFSEREEVDDGLFDEYHQLDVDPSHVHKSKSEHKHAVFVLGNSLATAMTEDEFSSAGRIGKRMKELAEDAESKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRZ6</accession>
    <name>A0A3N6LRZ6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD synthase</fullName>
            <ecNumber evidence="3">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">FMN adenylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Flavin adenine dinucleotide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ribL</name>
        <name evidence="5" type="ORF">EA462_08230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal FAD synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89984">
        <property type="protein sequence ID" value="RQG89984"/>
        <property type="gene ID" value="EA462_08230"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046444">
        <property type="term" value="P:FMN metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02115">
        <property type="entry name" value="FAD_synth_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024902">
        <property type="entry name" value="FAD_synth_RibL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 3" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="15"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="144" mass="15983" checksum="4D1D1C70E5C8078A" modified="2019-02-13" version="1">MTRTVIAQGTFDILHPGHVHYLEEAAAMGDELYVIVARSTNVDHKKAPICPATQRRDVVAALESVDEAVLGHETDIFVPIEEIGPDVIALGHDQHHDESRIDTELERRGIDCEIVRAGAREPASGDELFSTRLIVDRILERRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS62</accession>
    <name>A0A3N6LS62_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_08780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90084">
        <property type="protein sequence ID" value="RQG90084"/>
        <property type="gene ID" value="EA462_08780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="200"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG90084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="437" mass="48049" checksum="6ED33009129F4473" modified="2019-02-13" version="1">MESDQQSPPAKEQRRSSNGAAESALETARRQLSRGSSHLELGDAVRERLRHPTTVHEVTVPLERDDGTVEMFTGYRAQHDSVRGPYKGGLRYHPDVTRDECVGLSMWMTWKCAVMDLPFGGAKGGIVVDPKSLSEGERERLTRRFTQEIRDVIGPTRDIPAPDMGTDPQTMAWIMDAYSMQEGETIPGVVTGKPPVIGGSHGREEAPGRSVAIVTRETCDYYDRPLSETTVAVQGFGSVGANAARLLQEWGATIVSISDVNGAIYDADGFDVGAIPGHDEEPEAVTRYATENSDVTRLSNEELLALDVDVLIPAAVGNVLTADNADDVRADLVVEGANGPTTFAASAIFEEREIPVIPDILANAGGVTVSYFEWLQDINRRRWTLEEVTTELESEMVRAWNVVREEVDRRDVTWRDGAYVVALSRIDEAHEMRGLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSI9</accession>
    <name>A0A3N6LSI9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps10</name>
        <name evidence="6" type="ORF">EA462_05760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91467">
        <property type="protein sequence ID" value="RQG91467"/>
        <property type="gene ID" value="EA462_05760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="111" mass="12548" checksum="E3FFA0F78FB5E45C" modified="2019-02-13" version="1">MTFVTRLTLQSGDRAALDGIVDDIKSTAERKGAALKGPHSRPPRKYSVPQHCRLHADDDRRFSSWTYTVFTRELEIHGHDNLARNIASQNFPDSVHIEAKVEQIHSAGREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT71</accession>
    <name>A0A3N6LT71_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93213">
        <property type="protein sequence ID" value="RQG93213"/>
        <property type="gene ID" value="EA462_03190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040493">
        <property type="entry name" value="DUF5518"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17647">
        <property type="entry name" value="DUF5518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="182" mass="19548" checksum="D9814564EF96B7CB" modified="2019-02-13" version="1">MVTGRTVINALIGALVGVVLSFIPFSTVVGGAAAGFLEGPDGRDGAIVGLIAGLITFVPIAGMTVLGLGVLGLGMGFAAVPFEGFAVVLFFAVVASTVVLFYTVGLALLGGYLGAYLAREYPEKRTNTRETFGMRRDERSRHDRSESRRRDRTRESTALESEAEDERHDSARWREEDDTSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LTC8</accession>
    <name>A0A3N6LTC8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_01590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93293">
        <property type="protein sequence ID" value="RQG93293"/>
        <property type="gene ID" value="EA462_01590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="88"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="160"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="399"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="611" mass="67958" checksum="8F1FF3B66A25E5F5" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUW8</accession>
    <name>A0A3N6LUW8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91404">
        <property type="protein sequence ID" value="RQG91404"/>
        <property type="gene ID" value="EA462_05380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="61" mass="7144" checksum="825A2483015EB1B0" modified="2019-02-13" version="1">MSTDLRTPTARVCERCGRAEYWDDELEAWQIDHEDGEKQVGNPHCLHEWDINGTFNPVLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LW98</accession>
    <name>A0A3N6LW98_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_02570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93107">
        <property type="protein sequence ID" value="RQG93107"/>
        <property type="gene ID" value="EA462_02570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="299"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="405" mass="46348" checksum="A0F090795E3BFF39" modified="2019-02-13" version="1">MEYRRTAVIKLDTPEGADGSLRETVEQFKHCANTASEWCWHGDDGYHVTSKAKAERALYDRLRDETDLTANLVQKGIRRAVEAVKSGVERLKRGENTSQPHFSADSAVYDKRSATFHRDHVSLSTVDGRVECDYILPDNSETPPTKYVSDEDFEFRMAHLQYRDGNWYLHASMRKVEANDESPESKSKHRTVLGVDLGVNNLAVASTGRFWSADEFNHWRREYEKRRGSLQQCGSRQTHKNIESVGRKEYGRFEIHLHTVANELIKEAVENDCSHIVFEDLTYIRENIPEATWQHVWAFRRLYEYVEYKAEEHGVEAVQVDPRNTSKRCSTCGFTHDANRSGESFECQKCGYENHADYNASKNIGLQYLRRRQNAGDGGAPVDVRLNRGTLNVSGEYVPPASTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWA7</accession>
    <name>A0A3N6LWA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93117">
        <property type="protein sequence ID" value="RQG93117"/>
        <property type="gene ID" value="EA462_02620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="163" mass="17379" checksum="2615AD3DE037AE8C" modified="2019-02-13" version="1">MLHSSLHSKSSVRSRAQTEPIAALVAIALVCSGIVLYAGVLADIYPGGTDRDPADATLEQVWNSVGTDGVYRETRDRSELHQGVRLPEGYTAFITVTTVTDDGRSLTVDSVFVDRSIGVQYDASEIDRPDDTASASRSIGVHVEPAPAGDVRGGTLHVEVWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWD1</accession>
    <name>A0A3N6LWD1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93147">
        <property type="protein sequence ID" value="RQG93147"/>
        <property type="gene ID" value="EA462_02790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="65" mass="7302" checksum="EADD97785CEF6BD0" modified="2019-02-13" version="1">MVRKKKLSPSGAKDDDGNYHNVHLNLHEDELAVAGMDIGDEVFVRVRDGKIIIQKADGEDVEHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LX51</accession>
    <name>A0A3N6LX51_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_17105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86187">
        <property type="protein sequence ID" value="RQG86187"/>
        <property type="gene ID" value="EA462_17105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="423" mass="47038" checksum="A231C802420E430B" modified="2019-02-13" version="1">MERYDLVYRLFDEYDTQTLREYQEFVDIFPAVDSRVALEHWQTATEELERRKDEIRTGFAAGETFAEVASRANRDQAFTALDLETKYGRDVNVLVLDVDETLRSAGGTDNEIPRETLYVLTEFYDAGVPIVICTGQTLENVKGFAIQGLGSEIVHSGDLSIVYEAGTGVFTPGHGAETKQLLYEDLEPEIRDVFDDIRSRVLPEAPEQLRRGCHLQGNEFNVTMKPNYETGSTSAREIIDEALVYLIDLLADAIAIELDSIGVSDDGESDSEAVVDWTRTFYATQDPEIRTVLEREGAYPDLDVGGVPDELSAVLERIDVAYYEADAAEIGSLELNKVVGVERALDVLGVDDPFALVMGDSKSDLRVMEWVTENDAGISAAPEHASEDTLAHVLETDELVFDRGQSVDVLRTVYALNRLARLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXA0</accession>
    <name>A0A3N6LXA0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86651">
        <property type="protein sequence ID" value="RQG86651"/>
        <property type="gene ID" value="EA462_16010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="60" mass="7035" checksum="C239F6F05E772FDD" modified="2019-02-13" version="1">MIVQFRRLSEQRAPDTSPVLGRTSRVVQIDGERLRARTRTPARAAPMKQSMETLELWHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXU5</accession>
    <name>A0A3N6LXU5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_17235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86098">
        <property type="protein sequence ID" value="RQG86098"/>
        <property type="gene ID" value="EA462_17235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="340"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="427"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="501" mass="54354" checksum="F4DCA38E42463008" modified="2019-02-13" version="1" fragment="single">MFSIRRVISDSTRSIRRFVSDRFGSFHRILPDRIRGSYVAKFGLVILTVLVVTAGVAGFFYVDISDRITEETQNEMQVTAEFEADDVGTQIENYEATVTMLASNERFVDGSPNEIQTGLTTEIMWMTGDVEALHYIDYESDTIEYSSEHSQVGDDVSEFGFSVHTRDRSDVTEYEYDEADFSSIDSTYTDTYEHDGETQIAFLSPISESDGTHAIMMIVSVEEMSSDFSDPIEGSHTEVIDGVDGDVMVSQESESLLSTYRGGDSEGVIERAENGSGTIEFDGTDEVAAYAPVSGTDWVLVTQAPQSNAYALVDNVANSLIALIAVAMAGFLVIGATIGRSTANALGDLADDATALSNGETDIEIEDSGRIDEVGQVRSSFDDIRAYLETATAQSDAIARQEFDDPALDEDVPGTLGASLQTMGSDLESYIDDVEAARAQAEQSSEDAASARREAEELAERLEQKATEFGRVMGIAADGDLTQRLDDDVDNEALAEIAAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY43</accession>
    <name>A0A3N6LY43_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_15310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87011">
        <property type="protein sequence ID" value="RQG87011"/>
        <property type="gene ID" value="EA462_15310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="142" mass="15579" checksum="E6F5301C26EC5AF1" modified="2019-02-13" version="1">MSTQATEDRILEVLESDAQASYAEIADRANVSKPTVRKYIKQLEEDGVIVGYSADIDPKKLSSQTIALVGLDVASERYIEATKALKEYDEIEALYSSSGDHMLMAEVRAADGDELGEIISDELLEIDGVTAAHPSFLQERLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYG1</accession>
    <name>A0A3N6LYG1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92904">
        <property type="protein sequence ID" value="RQG92904"/>
        <property type="gene ID" value="EA462_01395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="28231" checksum="9B595B75C0700D69" modified="2019-02-13" version="1">MDLGLVVGVVVIGLVHGVLPDHGWPIAATYALNRNRRLLYGLLAAVILGAGHLISSVALVLAYFWFSSFAAFAEGPWLGYIAGTILIALGLSEYRHGGHAHGHHDGEKGHDHTHHDEHHEGTTHDGHDHHHEDGGHSHVHHSAEPGLGTRVRRALPGGGGHHHLSEEHAERGLMALGTTALLLGFAHEEPIQILAICVGTEACLELMVVYSLAVIVAIVTPTLLLIAGYEHHRDRIERFTPYLPTITAVVLVGMGLAFITGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYZ9</accession>
    <name>A0A3N6LYZ9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86972">
        <property type="protein sequence ID" value="RQG86972"/>
        <property type="gene ID" value="EA462_15065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="1">
        <location>
            <begin position="31"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="175" mass="20372" checksum="1C094CE3C36B613F" modified="2019-02-13" version="1">MVETRETTPIPTTILRDTREQRPWTFEGCPVETRDVTLSTGDYAVPTHCSHDQEIDTYHPQFAVERKSGPDFLTALTWERERFKRELQRTVQWAQPLPVVVETSWETLLRNHGCMAWRDIHPNQVTGTVAAWTDHYNVAFHFIETRRRAELCAYLLLVRHSLVRRLDDSSPGGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ28</accession>
    <name>A0A3N6LZ28_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="7">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpS</name>
        <name evidence="10" type="ORF">EA462_02775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93144">
        <property type="protein sequence ID" value="RQG93144"/>
        <property type="gene ID" value="EA462_02775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_A">
        <property type="entry name" value="Trp_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020653">
        <property type="entry name" value="Tryptophan-tRNA-ligase_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="446"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="123"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="430"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG93144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="550" mass="61302" checksum="FFC88A46B4FE8B6C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZR5</accession>
    <name>A0A3N6LZR5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_10310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88790">
        <property type="protein sequence ID" value="RQG88790"/>
        <property type="gene ID" value="EA462_10310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG88790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="137" mass="15546" checksum="AD3E66EEFDC80231" modified="2019-02-13" version="1">MDDLDRQILDILRRDARTPYTEIADEVETSEGTVRNRVERMMDDDVIERFTISTRTGNVKAMVEISVAVDVDTKAVSERIASWEEVDFVWMVSGEQDIVLVVDAADTRGVNDLITQARDQEEVVSTKTRLILDEQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M026</accession>
    <name>A0A3N6M026_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87864">
        <property type="protein sequence ID" value="RQG87864"/>
        <property type="gene ID" value="EA462_13455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="154"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="312" mass="34583" checksum="A5BCCA972522C3FC" modified="2019-02-13" version="1">MTCNVMSLTGSSCDMPGVHRFEHAELGVTDLEEATAFYTDVVGLIEIRDDGDCVYLGSGLDETFDIAIREGDTGIDHFAVRVADRDELERYKARLDDAGVDVKRDDGNEPGQTAGLRFDLPSGTRMELATVEDRRYQHSNEVHGDGRGGAAPMGVDHITLASHRVKDDATFLANHLDFSVSTAVTDDPDAEEWSGAFTRRGDYHHDVAFLPHPDPESTMHHISWEVKTVDHMKSFIDRINQHDVPLEFGIGRHYAGDNVFSYFQTPGGNRIELTAEMATVDPAADTEYLPFERALSAWGPVRPPESFQEDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M073</accession>
    <name>A0A3N6M073_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UbiD family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87924">
        <property type="protein sequence ID" value="RQG87924"/>
        <property type="gene ID" value="EA462_13765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="457" mass="51385" checksum="7A401730F25D4561" modified="2019-02-13" version="1">MRDLRSYLETLPDSQLERVSKSVNPAEFDVTAILQNLENEDRYPAVLFENPTDIEGRETDFRLISNVFADRRRIAQALDLSTDEWRMETSLEYGRRETNRQEPVVVDTDDAPVMEDAVPDLTHLPVVRHHRLDPAPYINMTPTMKDPESGVYNVAFLRNMVKGGEEMGIHMSPRHNFRIYKTNEDRGERTRMAVTIGHHPSYYLGALTLAGFEVDEYDVIGGMFGDPLRLTPSKTWGDEFLVPADAEVIVEAEVLPEVRETEAPFGEFPGYYGPQRLKPVVEVKNVVCRSDPIFQHVFVGHKDVATLGGVPKEGGIYNDIQGRVPSVEQVHLPSSGCGRFRCYVSLEQTTEGEAKHAALQALASSDFIKHVVVVDEDVDAFDEEEVLWAQSTRVRADEDIDIINGVKGNTLDPSVRGEVATSKIIIDATKPVDEQYPPVLDIPEDALERMTLTEYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0F4</accession>
    <name>A0A3N6M0F4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_12060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89100">
        <property type="protein sequence ID" value="RQG89100"/>
        <property type="gene ID" value="EA462_12060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="218" mass="23797" checksum="09C8BF3DCDFD1477" modified="2019-02-13" version="1">MKHVRLTLDADGREADVHPMYDVLLNAAAVDRATAMHWNVSDDELAIMHHVEGDIELFRAQLERIPEVVAYELTPAGEGAFYAYVRDRMTEPLRELFATASRGPLVVVPPLEYADGVVSYSVFGPSEAIQTALDRIPDPIDATVTAITGMAAVPGVLESLLSDRQREALEVALSLGYYEIPREASHEDVASEIGCAPSTAAEHLRKAESTVVRSVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0G8</accession>
    <name>A0A3N6M0G8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoA ester lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88044">
        <property type="protein sequence ID" value="RQG88044"/>
        <property type="gene ID" value="EA462_14430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="3">
        <location>
            <begin position="43"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="334" mass="36571" checksum="721C004FF9BC7698" modified="2019-02-13" version="1">MSFPRSDLGAAGRSVAFLSIHPRAFELRRKDGGMTTNTLGLRRSLLAVPGNETDLISMATDSDADEIILDLEDSIGPNNKIDARSNLAESVIANDWHGKTISYRINDVRSPWWYDDIIEIIEEVGEQIDSLIIPKVEDASDLHTVNNLLGPVLENAGIDPESIRITAQIETAAGMNNASDIAHSCTGLDAMIFGPGDYVASIGASGLSKESQREYPDHYWHYPLSKLSLAASSADLRVIDGPYADVDDVQGFRRSCEQSRKLGYDGKIVVHPGQVDIANTVYSPSKEEAEAAMRIVKKYDNSDGSAPKIDGRVIDRESYESAKKIAEQAKRIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1Q3</accession>
    <name>A0A3N6M1Q3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89011">
        <property type="protein sequence ID" value="RQG89011"/>
        <property type="gene ID" value="EA462_11545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="170" mass="19507" checksum="3383E852DE6F2515" modified="2019-02-13" version="1">MSADVSRRVEVYPGRTVTVEFDPTLTFECVDDCTWCCHHGVLLYDRDLIGLAQRANLAETTTEFRGEKFVTRENKDREDHVSGDGRACAFLRDDGLCTLHLEEDWKPTRCSVFPLGVWLEDDGLHVDIRESAHDHCDGLNVSQRRVIDNLEAFLPELLWELDDPDSNREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1V0</accession>
    <name>A0A3N6M1V0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89061">
        <property type="protein sequence ID" value="RQG89061"/>
        <property type="gene ID" value="EA462_11830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="117" mass="13006" checksum="80B977B7BF712129" modified="2019-02-13" version="1">MRIDDNNSRSRRNLLKKSGAIGLGAISLSGSAGAHDESVRNLHSEDDFKAENYVEREEFIYRRVQTAETEMLLRLDLGKGEAVFAEMKYARTAEGLTDSPMDGSVEILSKLQIQSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M241</accession>
    <name>A0A3N6M241_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89171">
        <property type="protein sequence ID" value="RQG89171"/>
        <property type="gene ID" value="EA462_12450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="163" mass="17406" checksum="2438232BEB342AF8" modified="2019-02-13" version="1">MNRRVFGRTVAVGIGSVIAGGCLGGGADGGSTSDPDSAQTDDDAASSSDEGSPADDGRESAQALEAGFDSRGLDVLESEVDGSDRIVMTIQTSGNLDEDIRIAGGAYATEAQQIERDLTVRTEDRGLHQETFTIERDWAVRVATDRMSDEEYLERIEETRTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2A6</accession>
    <name>A0A3N6M2A6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalamin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_12875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89251">
        <property type="protein sequence ID" value="RQG89251"/>
        <property type="gene ID" value="EA462_12875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="67"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="326" mass="34677" checksum="4BF69904B8169722" modified="2019-02-13" version="1">MRESNANEPTTGTDEREDSVGSRSATALRSDGGHPQEAIDAQGSRRGETLDARIFEHNAGDDQEGIPFVGAGPGDPGLLTVTGSKLLEDADLVVHAGSLVNSELLEEYCDHAELVNSVGKDLETLVPLMRDAYEDGRAVVRLHSGDPAIYGAALEQMDALEHEGVPTYFVPGVTSAFAASATLRTQLTLNEVSNHVAFTRPQGKTLTEADDHVSDFVGMGDVTTCLYLGTHAVSETMDRLLDDGHDPETPVAVIYHASWPDEDVIVGTIDTIGAQVEEAGYRASAVVVIGDAVTARGYERSYLYGDWANRGDSSEANDAETQADGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2B7</accession>
    <name>A0A3N6M2B7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-3-methyladenine glycosylase 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89950">
        <property type="protein sequence ID" value="RQG89950"/>
        <property type="gene ID" value="EA462_08040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="126"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="293" mass="33090" checksum="0D5DB08C4F1367F7" modified="2019-02-13" version="1">MESGTIPIDDLSGGFDLYRTLESGQSYLWRREDGEMYGGEPAPDAWYTTVVDGTVIRVRRHDDRLEWESTMDAHRTVSRLLCLEDDLEAIIEAAPDDRLLETAYDAHRGMRLVSDPLFGTLISFICSAQMRVSRIHSMVTTLAREYGDEIAFDGRTYHAFPTPDRLARATEAELRALGLGYRAPYVVRTAEMVASGDAHPAEARNLPYEEAREYLTRFVGVGDKVADCVLLFSLEFTQAVPLDTWIKSAIEEYYPDCDRGSYATTSRAIRERLGGEYAGYAQTYIFHHLRTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2D7</accession>
    <name>A0A3N6M2D7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89970">
        <property type="protein sequence ID" value="RQG89970"/>
        <property type="gene ID" value="EA462_08160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="104" mass="11985" checksum="F8B11645EF52F8E3" modified="2019-02-13" version="1">MQKPSVKCALLATMIAKHKWGTPITKEGLLSLSAIDGNYPTARDVYDDLRSEPYITYRGNRGIELDKGNFDGLADVLYHECNWEKWEIDSRLKHYEGIEDHDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2V7</accession>
    <name>A0A3N6M2V7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="9">2.7.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">4-methyl-5-beta-hydroxyethylthiazole kinase</fullName>
            <shortName evidence="9">TH kinase</shortName>
            <shortName evidence="9">Thz kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiM</name>
        <name evidence="10" type="ORF">EA462_09230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Thz kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90160">
        <property type="protein sequence ID" value="RQG90160"/>
        <property type="gene ID" value="EA462_09230"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000513">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG90160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="277" mass="28584" checksum="836AC6E5BD99B157" modified="2019-02-13" version="1">MSESIDVTGDELAASLRAVDATEPLVQSLTNEVTMNDVANLILHWNALPVMADSPGDAGEMADLSSAVQINTGQLPDAKIEAMAEAGRRANERGVPVVLDPVGVGSTPSREAVAERLLSEIEFSIIKGNYGEISALAGVEADVKGVESVGDYEEIERTAGSLADSTGATVVASGVDDIVADPDSVYRLTAGHEMLAAVVGTGCMLGATLAVFSGALGDEHAAAVHGTLAFGIAGERAAGRPYDGPASYRTNFHDAVYGFSPDVAADLDLENRIERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3M2</accession>
    <name>A0A3N6M3M2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86717">
        <property type="protein sequence ID" value="RQG86717"/>
        <property type="gene ID" value="EA462_16405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="15"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="154" mass="16688" checksum="252832E8AB9F483A" modified="2019-02-13" version="1">MLATVIRTNLLMVGSATHYGLNVADMEEAIAFYEGTLGLEVDRSFPISEVQSDIVGVEGVEGDITFLDAGGFSIELIAYDEPPNENVHDEASGHDVGVAHLCLEVEDIWNLYDDLAPDVEFVNEPETVGNGAQIAYLRDPDGNYVELMEPPADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M431</accession>
    <name>A0A3N6M431_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89981">
        <property type="protein sequence ID" value="RQG89981"/>
        <property type="gene ID" value="EA462_08215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="109" mass="11869" checksum="5B62156CA7169E4E" modified="2019-02-13" version="1">MARENPVRSQTDTTTDDRLPNLITIVGRGVPSMFEIAVDGELEMLGDDPAEDATVVSQKVAEGTIDVGVRRFRFSGRMANVTVVDWNGVPAPDSPSTPTIHIDYDVPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4G4</accession>
    <name>A0A3N6M4G4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_15525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87047">
        <property type="protein sequence ID" value="RQG87047"/>
        <property type="gene ID" value="EA462_15525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DZANK-type" evidence="5">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="195" mass="21900" checksum="468D024C6B767648" modified="2019-02-13" version="1">MSKITFRADDDLIEELESLEISKSEAMREALRSYLGEPTQVDSGTEREANETAIDDLVRDRVDELLTERLETRTSPHRVRSRTSERHDLNLSISFEGVEGASVEPSKTRTGSVDAEYESEAVTRDRTGSSEQNRERTQCGQCGEHVDDDHVYCPNCGEKASRRLFCECGDELRSDWSFCPSCGRRTPAADVLESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4I9</accession>
    <name>A0A3N6M4I9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87077">
        <property type="protein sequence ID" value="RQG87077"/>
        <property type="gene ID" value="EA462_15710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="537" mass="56506" checksum="410909C6635C6987" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4U2</accession>
    <name>A0A3N6M4U2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90261">
        <property type="protein sequence ID" value="RQG90261"/>
        <property type="gene ID" value="EA462_09785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="166" mass="17681" checksum="CD76490A3CA0D8C3" modified="2019-02-13" version="1">MNKKGHVLNAVLLSIGLGYLLEPATQLSQAQATIESIVMIAVPVTLGALFPDVDTAFGKHRKTLHNLAVLGAFVAYPYAFAGNLEYVWIGVLTHYVLDVAGSRRGIALFYPLSSTEYSLPTGVAVSSKYATVVTVIVTAGELALAAAIVYEVPQWGFELGRQTIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M568</accession>
    <name>A0A3N6M568_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_03965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA damage repair.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nre family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91160">
        <property type="protein sequence ID" value="RQG91160"/>
        <property type="gene ID" value="EA462_03965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02096">
        <property type="entry name" value="Nre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033167">
        <property type="entry name" value="Nre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006979">
        <property type="entry name" value="Nre_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006978">
        <property type="entry name" value="Nre_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136">
        <property type="entry name" value="PTHR38136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04895">
        <property type="entry name" value="Nre_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04894">
        <property type="entry name" value="Nre_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nre_N" evidence="2">
        <location>
            <begin position="21"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Nre_C" evidence="3">
        <location>
            <begin position="321"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="451" mass="49792" checksum="EDC7E7FC2154BD32" modified="2019-02-13" version="1">MRLDDYIEELEPDEEAERRRLAKEKSYAITDHLEDVRTRFDDALSGDTLVGSTAPSIFVGRSNYPDIPVGLLSPVGDEDAAEEYVTDGNWYRQGYAIDDVLQRRTGLLNSSKRANVDSPSIASRLTPSVHDAWDGFVGVQREVAIAGRPVDLEIGLDGTPDIGLDAGADVATPRGPRASARNAELRENPYVPTQVKKTLEDDDWQAQGAMTYLYRRGFDVYEINSILSAGALGEAKQRRLVPTRWSITAVDDTVGQFLRGRIRNEPSIDEVQVWANEYVGNRYWIVLAPGRWEFELVEMKAPGSIWNPDPHDEVWMASASEGYEGRSGYVEETAGAYYAARLGVLEHLESIGRQAKCLVLREVSDDYWAPVGVWQVRESVRNAFDGPPGGARGLTDGERSALAGEHGRAETFHDAVTAVATQLPVSFERLKRKSELAAGLQSSLDAFGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5A0</accession>
    <name>A0A3N6M5A0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-hydroxy-acid oxidizing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_13580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87889">
        <property type="protein sequence ID" value="RQG87889"/>
        <property type="gene ID" value="EA462_13580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="382" mass="40931" checksum="1126B5807B003999" modified="2019-02-13" version="1">MTNASESPLERRLREIETERTAVPFDYDELERVALERLPSASASYVAATAGTGETGRANRREFDRWRIVPRVLRDVSDRSLGVDLFEKTLRSPLLLAPIGGQTKYHEDGELASVRAATELGVPFALSTASSYSIEDVAETDDSNLLFQLYCTSDFDTTVNLLERAERAGYDGILLTVDFQVPRWSPETLSRTNDQLYASSLANLSADSPANSVSDTTADPLARDESLSWEDLSALTEATTLPIYLKGITHPEDARLAVEHGMDGVVVSNHGGRQVDGSIAAITALPHVADAVGADVPVLFDSGVRGGADAFKAIALGADAVFLGRPYLYGLTIAGQRGVYEVVHNVLAELDSVVGLSGYDSIANVDRSAIVDGSSIGSMGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5S4</accession>
    <name>A0A3N6M5S4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91380">
        <property type="protein sequence ID" value="RQG91380"/>
        <property type="gene ID" value="EA462_05240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="133" mass="15116" checksum="4E6A10C6E2D449DD" modified="2019-02-13" version="1">MASIPTESRDLFKKKKTFAHLATLLPDGAPHVVPVWVEYDADADRLLVNTQRGRRKEKNVRQQSRVAISMTDPDNPYRMLSVRGEVDDITSEGAHEQVNRMAERYLGDGDYADPQTERVIISIRPEQVSYSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6F5</accession>
    <name>A0A3N6M6F5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_10845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88886">
        <property type="protein sequence ID" value="RQG88886"/>
        <property type="gene ID" value="EA462_10845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="PTHR43127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="61"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="292"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="369" mass="41065" checksum="68A653E8D1F5F0B7" modified="2019-02-13" version="1">MGLEEEIDAIEEEIANTPYNKSTEAHIGRLKSKLADKKEKLQNQSSSGGGGGYSVEKHGDATVALVGFPSVGKSSLLNSLTNAESEIGSYEFTTLDVNPGMLSHRGANIQMLDVPGLIEGAASGRGDGQQVLAVVRNADLIVFVLSVFEIDQYDRLQEELYDINIRVDREPPRVTVRPKIKDGIKITSSADQDLDEETISDVLREHGYVNAVLNLQETVTIDRLIDGLMENREYIPSITCVNKVDLIEPEYKETVDDQLRDRDLDPDEVTFISAEKERGLDALKDRLWENLGLIRVYMNKPSRGIDWEEPLVIETGSTVGEAIENLGGEMEERFRFARVTGPSATHDEQQVGTDHVLEDEDVLKLILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6U6</accession>
    <name>A0A3N6M6U6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">V-ATPase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atpE</name>
        <name evidence="7" type="ORF">EA462_11805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89056">
        <property type="protein sequence ID" value="RQG89056"/>
        <property type="gene ID" value="EA462_11805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="195" mass="22171" checksum="CEF1D17B99ED03C3" modified="2019-02-13" version="1">MSLDTVVEDIRDEARARAENIRAEGEARAEEIVSAAEEDAEEILESAERDVDREIEQLREQRLSSAKLEAKQQRLEARRDVLGDVREAVETELATLEGDDREELTRSLLDAASVEFENGDDVSVYGRDDDAELIESILEDEEYADYEYSGSYDCLGGVVIESEGSRLRVNNTFDSVLEDVWEDNLREISNRLFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M824</accession>
    <name>A0A3N6M824_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91511">
        <property type="protein sequence ID" value="RQG91511"/>
        <property type="gene ID" value="EA462_05995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="2">
        <location>
            <begin position="289"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="476" mass="52854" checksum="A55A5974AFDAE83C" modified="2019-02-13" version="1">MVTGWQYRTVSVLGVLVLTIGAVALANHPTAQLLFTTYVPVFNRLEVTVLSDRSLYWAITLSVVAVGCSLVPLYKPQPRRVLDTVVLSQKRILVAGLAIATLGYFNWSHRLPRATLVMTFAILGIVVPAWFVWIRRRPPEEADRTLVVGDDLEQIERISPSVSVPVLGYLCPSVVNVRGEPTSVETAADGGVTVGDGGERDRLETPNRLGGLSRLENVLCEYDVDTVVLAFLNADRAEFFGALDTCHDHGVSVKIHREYADSVLVSEGDVGEIVDVDLEPWDPLDHLYKRVFDVAFATVGLAAFAPLFAVIALAIKLDSSGPVLYSQDRTAGFGETFPVYKFRTMVPEGESVTPSEDEENDRITGVGRVLRRTHLDELPQLWSILAGNMSVVGPRAAWTEEEVLLEEDAPAWRKRWFVKPGLTGLAQVNDASSTDPETKLRYDLEYIRRQSFWLDLKIVVRQVWRVLEDVLEMLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8V1</accession>
    <name>A0A3N6M8V1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89906">
        <property type="protein sequence ID" value="RQG89906"/>
        <property type="gene ID" value="EA462_07800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="133" mass="15278" checksum="1E61763D3273C89D" modified="2019-02-13" version="1">MVFSTLWTRLSSLWPGSSAGKVTSEESTAETERESERGESSDRTLSYAEQIEYGVDERDLPDEDKVLRLLVKRGGRIDETTLREETDWRGDHLENVIDRMEDDGQISAITVGRKRVICRRGFEPKGYRSHLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9D1</accession>
    <name>A0A3N6M9D1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_09040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90126">
        <property type="protein sequence ID" value="RQG90126"/>
        <property type="gene ID" value="EA462_09040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="182"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="248" mass="27786" checksum="6E062B6AAAD9ED3B" modified="2019-02-13" version="1">MREFVFALEYDPGTNPVADVLADYPDTSIRSLSCHVSADSLWRVDHASGSGEALEALERAYENADYFADCLVKDDCGADCEVQVLDRSNDTLVVYTYWERTSVCTSVPHVALEHLGDGLLFETYREGRRYRWRIVLGNEAPIHQFFDALGEEVGECTGMEMLRLTELDPQRAGIEPEETLPDEQRDALRAAVDYGYYETPRAIELSDLADRLDVPRSTLSYRLRRAEATLATTFVDGSEPIDGLAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9L6</accession>
    <name>A0A3N6M9L6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90216">
        <property type="protein sequence ID" value="RQG90216"/>
        <property type="gene ID" value="EA462_09525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="259" mass="26393" checksum="8A58809F17BAF73D" modified="2019-02-13" version="1">MIVVVPVAPPRTDLACASLVETTPLTDAQAVALYEAAVTDVLRAAAASGGDLLVNYRDEGTIPDGVGGTGGAKTDEAGGSTADPEDEVRTLVGDALESVEDVRFERQVGSSHAARIGNTVTHLLEREDAGTVGVLEPTAPLVGRSEIDSASMSLRRYDAVLGPSSGGRVYFAGFCDPIDFTDAYATPSLATLARGVEAAGLNLGFAPVVPTIATESGLCATIAALEARRIAGRPGATATGRAVDELGLTVGGDGRLERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBH1</accession>
    <name>A0A3N6MBH1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92811">
        <property type="protein sequence ID" value="RQG92811"/>
        <property type="gene ID" value="EA462_00860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="73" mass="8054" checksum="81C620C7B69C1C51" modified="2019-02-13" version="1">MSKVTDEPAQTREIGHDEFDPVGTLALIGLYFLILVVLWFFMYFVEFLGNDPTVVTGAVTATPLAVMAGVVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBU0</accession>
    <name>A0A3N6MBU0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005554588.1">
        <property type="nucleotide sequence ID" value="NZ_REFY01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92941">
        <property type="protein sequence ID" value="RQG92941"/>
        <property type="gene ID" value="EA462_01605"/>
    </dbReference>
    <dbReference type="GeneID" id="42300362"/>
    <dbReference type="GeneID" id="56143844"/>
    <dbReference type="GeneID" id="63184478"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="7128" checksum="FA8BE87281C7EE37" modified="2019-02-13" version="1">MAKGTVDFFNDTGGYGFIETEDADDDVFFHMEDIGGPDLEEGQELEFDIEQAPKGPRATNVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCP6</accession>
    <name>A0A3N6MCP6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase WbuB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_06020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91516">
        <property type="protein sequence ID" value="RQG91516"/>
        <property type="gene ID" value="EA462_06020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="22"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="224"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="419" mass="46699" checksum="72A5651E90B4296D" modified="2019-02-13" version="1">MADDSESVLVVTQYFPPETGASQTRWDELSRRWSDEVPVTVLTSAPDYPEGELYDGYDNRWLRRERRGDVEVLYTKTITSSSGNLLRRSLKFVWFMLISTIIGIRYTSPSVVVATSPQPLTGVSAWITARVKGGSFVFEVRDLWPESILAVSEFGNRFVIRGMERTVAFLYRRADHLIVVSQAFVDPIAECGVDRSKISFHPNGIDLEFYRRGPAESPVVDDIDDEFTVSYVGTIGRAHGLSVVLDAALELDDVQFVLVGDGAEREELEVRAAGLDNVVFAGRRPKEEVPAILRESDIALVHLKPRDVFETVIPSKLLESMAAELPIILGVHGEAERILTEADAGIAIEPGSGDELIAAAEQLRENPEQRQMFAFAGREYVVEQFDWETIADAYLTTITEDPDQRSDARPEQSVTNADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCS7</accession>
    <name>A0A3N6MCS7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93311">
        <property type="protein sequence ID" value="RQG93311"/>
        <property type="gene ID" value="EA462_02480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002753">
        <property type="entry name" value="UPF0058"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036519">
        <property type="entry name" value="UPF0058_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01893">
        <property type="entry name" value="UPF0058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140371">
        <property type="entry name" value="SSF140371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="78" mass="9106" checksum="334978C7ECABAFAC" modified="2019-02-13" version="1">MNSQELTHLHALLYEVRVELEDQDKVPAGAFSEYDSKNVRPDYIHRPQDAHEDGIRLLLKGIRHSIKRDPPPEKEMTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCZ7</accession>
    <name>A0A3N6MCZ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF456 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91646">
        <property type="protein sequence ID" value="RQG91646"/>
        <property type="gene ID" value="EA462_06775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="199" mass="21423" checksum="B917DB408206B43B" modified="2019-02-13" version="1">MTDRSDELTERRETDSSQDILEETDRLLSESEAGDASSERRSHERADRQHADEHRETATEHHQPMDEPSTATGGSRFRPSRSLGEYFSPKAFFALALLVSAGLLAGQTLSPIGSIGRIGGMFAIAFFVGLLTSKRRYLEVSAVGVSVGAVAMVLFDFTLAVVGSGRLLVAIGAAVGLVATVAGYYFGRDLRDGLVRDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MD23</accession>
    <name>A0A3N6MD23_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Photosystem reaction center subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91676">
        <property type="protein sequence ID" value="RQG91676"/>
        <property type="gene ID" value="EA462_06950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="81" mass="8806" checksum="8E2FA1E612FA22D5" modified="2019-02-13" version="1">MSDILAENLSGKSVMGSDGTELGLLYNITMDLKSGSLHNLIVEPDEALPSNAIDFDVDEAGRFLVPVNRVQAVKDYIVVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MD59</accession>
    <name>A0A3N6MD59_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nac</name>
        <name evidence="7" type="ORF">EA462_05705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Contacts the emerging nascent chain on the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with the ribosome. Binds ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91716">
        <property type="protein sequence ID" value="RQG91716"/>
        <property type="gene ID" value="EA462_05705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00814">
        <property type="entry name" value="NAC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005231">
        <property type="entry name" value="NAC_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00264">
        <property type="entry name" value="TIGR00264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="6">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="125" mass="13071" checksum="AEC62D7AF22229E0" modified="2019-02-13" version="1">MFGGGGGLNPRKMEQMMKQMGIDVDDIDAQEVVIRTDEYDLVFDNPEVTKMDARGQETYQIIGSPEEVEAGSAGGTPAVDGDAGAGIPQDDVELVAERANVSEDEARDALEAAGGDLAAAIGNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MG84</accession>
    <name>A0A3N6MG84_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92946">
        <property type="protein sequence ID" value="RQG92946"/>
        <property type="gene ID" value="EA462_01635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="34"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="312" mass="34072" checksum="3F2D623E1F953814" modified="2019-02-13" version="1">MPRAICDDASIFYEYDEDASDESRSGSIDVEEPIVFVQDLGYGRWMWRWQREAVSGDVIAPDTRGTGRSGAGLPPIVPRLPRRLRTPLLSGVASYSVAGLAADLEAVLEDAGVRRAHLVGAGLGGMIVQQHAIEYSRAKTLTLCGTSHGGTDAVAMSEETRSTLLERPSGANEREGLRHRMRPAFSERFTNRNPHLMDRIVEWRREQDAGAPALEAQIAAIDTFDGRDRLDRIRAPTLVIHGTDDRIVPSGNARLLEEAIPNARLELVEGGSHCCFIESADRVNELLGTFLEDSSEPGGETPDFRAGRVGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSS0</accession>
    <name>A0A3N6MSS0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_13105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87805">
        <property type="protein sequence ID" value="RQG87805"/>
        <property type="gene ID" value="EA462_13105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="17"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="347" mass="38999" checksum="B3114240CBE060DC" modified="2019-02-13" version="1">MSITTKPESDSDSQALIDVNDLSKLYETNQSIISRLFGEKEYLRAVDNVSFEIQQGEIVGLAGQSGCGKSTLGELLVQLQEPSSGEIIIDGDDITEYSSSELKTFRRKCQVIFQDPYEAINPRFTVSRIVSEPLKIHSIGDRQERTERTIKALNDAGLSPAEEYLGSFPRELSGGERQRVNIARAIVLEPDFLIADEPVSMLDVSVRTGILKLFEKFKEEMEMSILYVSHDLSTINYLCDRTMIMYLGKVVEVGKTRNVIHYPSHPYTKTLLQSVPDTQKQTDITEESVQGEVPDPIDLPPGCRYASWCSYADEKCERDEPLLQQRDDGEEASDQVACHYPIENNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTD0</accession>
    <name>A0A3N6MTD0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_14490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88055">
        <property type="protein sequence ID" value="RQG88055"/>
        <property type="gene ID" value="EA462_14490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="234"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG88055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="389" mass="42659" checksum="FC3AF351E14433CD" modified="2019-02-13" version="1">MNFDWPQEYALIKQVIADIVEDYPDEYWRDVRAENRFPTELYQDLADGGWLGILFPERFDGQDMDLLALLAVVEALAEEGAWIGAVSLISGPVFGGLSVLEHGTEAQKERYLPSIVDGSERWALGVTEANAGLNTTNIQTKAERDGDEFVIEGGKQFISGVDHSHRMLLLARTTAKADVDSPADGITMFILDLEDDAISYDEIDLDIYYPERTFEIQLDEVRVSEEDVLGTVDGGFQQLFDTLNTERIILGACSWGAGKTVLDAAVEQARERVVWSEPIGGHQAIQHPLADAYADLESARLVLRKAAWQQSNGRDGVGEAANLANLQAGKAAWSAAEASMTTFGGMSVASEMGVAAAWGFIRHARTVPVSEEMIRNYLGQHTLGLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXA4</accession>
    <name>A0A3N6MXA4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90132">
        <property type="protein sequence ID" value="RQG90132"/>
        <property type="gene ID" value="EA462_09075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="184" mass="20852" checksum="17B0DA2AE0F2EB90" modified="2019-02-13" version="1">MIWPVFLSLFWAGIATAYVSVVRREVELLFAGLSFLCWLGVAFSSTSIQVAVGESLETVGEPGLTATTGRSPIQGVARRPRGKPESLGSKDSEYVDTIVEADKIHERWESWLETDFSKDFPLAKYPGGHAEDEELLVLNRMDMFLDRHYDRRTGREDGTATKIHRRPVTEHDTQLARRTRRLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXS6</accession>
    <name>A0A3N6MXS6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90332">
        <property type="protein sequence ID" value="RQG90332"/>
        <property type="gene ID" value="EA462_10180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="143" mass="15442" checksum="B2B484428A2F00DF" modified="2019-02-13" version="1">MYDSILVATDGSDDATTAADHAVGLARRLEVPLYGIAVIESRIEYDNAIVDPAEIDRRRRERTDSSLSKLEKAADDVGVTVETTVRSGVPHEEILEYADDCDAGAIVVGSRGRSSFRRALLGSTVDAVVRLAVRPVIVIESED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXU8</accession>
    <name>A0A3N6MXU8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90362">
        <property type="protein sequence ID" value="RQG90362"/>
        <property type="gene ID" value="EA462_08155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043853">
        <property type="entry name" value="DUF5815"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19132">
        <property type="entry name" value="DUF5815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="178" mass="20191" checksum="9544612DBF5C9C72" modified="2019-02-13" version="1">MVEPRVPGSGTDRRLELPCGETIDPHEIDLGMREYTCSCGTAHAVVTDVHPPSRFFPESLVSVLRETIETADEFDQFGTPHLMGVVLEEFPDRTAVHDASGDGAVGYSMVWISDFDARRLHEIVVELVVELMEHAISHAEDDHSRTQFESQMLEFDVSEFVDQYRAQREFETEHDRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N097</accession>
    <name>A0A3N6N097_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase expression protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91302">
        <property type="protein sequence ID" value="RQG91302"/>
        <property type="gene ID" value="EA462_04760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="34"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="165"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="341" mass="35057" checksum="710B03ED3477B267" modified="2019-02-13" version="1">MPGKVPPDELLAHVFDRTDSGADETILQGPAEGEDAAVIDWPGGDLVVSSDPISLAASQVGTLGVYVACNDVAASGADPRWLTVVVLLPGSERETDGLRHSSDGDVATGETLLETIMTDLEAAAADVGATIVGGHSEYVDQIERPLISLTAMGATDSFVRTGGAEPGDAVILTKAPGIEGTAILAADFGDTLDVDDAIRDRAEQFLAEISVVPDARAVREYATAMHDPTEGGVAAGLLEIARASNVRLEIDREAVTVRPETEALCAAAGVDPLCIFGSGALLATVPQAALGGCLDTLTEAGVEATAIGTVGSGEPELRLDSTSITEPIEDDLYPLWEAVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0S9</accession>
    <name>A0A3N6N0S9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-antigen ligase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91522">
        <property type="protein sequence ID" value="RQG91522"/>
        <property type="gene ID" value="EA462_06050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="410" mass="44887" checksum="FE0A2803400EC487" modified="2019-02-13" version="1">MEVVPIGAMSAFGQFHSKIASIIIFILLFLSLLSFTMFGNTQVVNVLILGTVFGICMLWSSRHDEYIELPRFIFLPLLAIWAFFIISSVTVSPTISQSVLQTVAAIAISGTAIFIIPKVYSSGSFLFHIFLISFVLGLFSVLALILPLESIGPVELLRAVPYEEYVIFGEARYGEVPIAGLENPNQLSVVLLPGVLAGVSYLRTAVSKKPMSEIVISGIALLFPLISLILTRSRGGFIALIVGVVTFIAIHHFSTTIVRIFCLSGIIGSLLVLAPTGIGPVPSLIELVSEPRAWRWKHAIDSMQKQPFLGYGPGNSRLATQSGTQPHNAYYMLGLWGGLGPFILYLYMFARILLVSVRDRVNTMPAVFPAILTSYWIYSLFESVTIFHFTAPSVILVVTFGFVAHSFVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4W6</accession>
    <name>A0A3N6N4W6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glyS</name>
        <name evidence="9" type="ORF">EA462_03350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93242">
        <property type="protein sequence ID" value="RQG93242"/>
        <property type="gene ID" value="EA462_03350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="20"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG93242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="595" mass="66018" checksum="CFE07AA10961337B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NTW3</accession>
    <name>A0A3N6NTW3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_17280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86106">
        <property type="protein sequence ID" value="RQG86106"/>
        <property type="gene ID" value="EA462_17280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="469"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="601"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="818" mass="89973" checksum="2E14F7CC81FD9219" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYS8</accession>
    <name>A0A3N6NYS8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoA ester lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90019">
        <property type="protein sequence ID" value="RQG90019"/>
        <property type="gene ID" value="EA462_08415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="3">
        <location>
            <begin position="4"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="290" mass="31677" checksum="210E03EC0E6C37EF" modified="2019-02-13" version="1">MVRRSVLFTPGDRPEMLRKAANSSADVVVFDLEDAVSPDRTSTARENVRTVLADSDFDPKPEICLRTNAERDEFEADIDAVFGSEDADVSLDSVMCPKAGSPDDVRELVDALESYGESCPVFALIETARGVLAAPEIASVPATDALVFGAEDLAADIGARRTDDGTEVLYARERVVIAASVHGCDAIDTLVPDFEAEERLREETEFAITLGYDGKLAIHPAQIEPINESFTPNDDELEWATAVLEAKRHADREGRGVFELDGEMIDAPLIARAERIRRRHCVSRGGEIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZI2</accession>
    <name>A0A3N6NZI2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90379">
        <property type="protein sequence ID" value="RQG90379"/>
        <property type="gene ID" value="EA462_09365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="537" mass="58553" checksum="516215CD7548A02D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZT2</accession>
    <name>A0A3N6NZT2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monovalent cation/H+ antiporter subunit D family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87086">
        <property type="protein sequence ID" value="RQG87086"/>
        <property type="gene ID" value="EA462_15755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="2">
        <location>
            <begin position="134"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="512" mass="53178" checksum="C8ABABFB5CD19696" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0A6</accession>
    <name>A0A3N6P0A6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine pyrophosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_13420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87858">
        <property type="protein sequence ID" value="RQG87858"/>
        <property type="gene ID" value="EA462_13420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="207"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="395"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="559" mass="60812" checksum="E0E671E22383BCE6" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0C2</accession>
    <name>A0A3N6P0C2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske (2Fe-2S) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_13575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87888">
        <property type="protein sequence ID" value="RQG87888"/>
        <property type="gene ID" value="EA462_13575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="13039" checksum="0F354152AF656DEC" modified="2019-02-13" version="1">MSSTHVGSVDEFEHGDRKITTVDGASVGVFCVDGEFYALENECPHQGGPACTGRVGGEIVAEIPEPGKRKQERISDDLVVACPWHGWEFEIETGIHLGDDSICLDQFDVVVEDDEVYVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1S0</accession>
    <name>A0A3N6P1S0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91489">
        <property type="protein sequence ID" value="RQG91489"/>
        <property type="gene ID" value="EA462_05870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="133" mass="14452" checksum="1A87B82663D5F566" modified="2019-02-13" version="1">MSDETSDVDGSGESQPTSDGHDADSEWEWGKTEPVPSEDPPRDGSSDIEPVSTATDTDSETERDRIPIDLSRTPADDDRTEPDEDEDEDDPYAPEPSSTPIVAGEPDLENALFVIIGALAMILVTVRLIWIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P262</accession>
    <name>A0A3N6P262_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carotenoid biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91659">
        <property type="protein sequence ID" value="RQG91659"/>
        <property type="gene ID" value="EA462_06850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017823">
        <property type="entry name" value="CruF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007354">
        <property type="entry name" value="CruF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39419">
        <property type="entry name" value="PTHR39419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04240">
        <property type="entry name" value="Caroten_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03460">
        <property type="entry name" value="crt_membr_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="298" mass="32338" checksum="C19BE5F1B1007D23" modified="2019-02-13" version="1">MGNPENTESATEAGSANERGSWTRGSVQHRLEGLIRENRFTIAVVFPFVGAVTLVASAEGLLPAPLAYNPLFILFGTLVMRSPLVVGLLPRIGGWALACLGVLTVYTYAIEIVGVRTDWPYGAFEYTIQLGPMLLDAVPLALPLFFIPLVINAYLLTLLILGDRSDAAHYRIPAAIAAVVAIDLVLDPAAVAIGFWAFVPPGVYYGVPVSNYVGWVLSGTVAVVLVDLAFDRRALLERVRDCEFVLDDLVSFVLLWGTINLLYSNWLAAGVAGLFCLGLFGTDRYDLEMVRTSFPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P465</accession>
    <name>A0A3N6P465_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosylhomocysteine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92679">
        <property type="protein sequence ID" value="RQG92679"/>
        <property type="gene ID" value="EA462_00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="54"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="451" mass="49128" checksum="D80C311870B0CA44" modified="2019-02-13" version="1">MTQRLIRNGTVVSLDPDIGQLEEADVLIDDGEIVEIGHGLTASNAREIDASGQIVLPGFVDSHIHLAQTQVRGIAGDWSLMGEYFEHMLGNITGLYQPEDMYLGGLFGALEKLHTGTTTALDWSYPNSLEHAERAVDALQDSGLRAVYTYGPPGDDAAKWWFESDVGLPDQHIRELYAEKISDDDLLSLALGLRGPDFCTDETARTDLELARDLGALSTIHMGAALWPSSVYSEDYQGFGCIQDMLGPDVNVAHGNHFTQEDIDYAVEQGVSFSSSPEVEMQMGHGIPVTEKVINAGGRPAWGVDVCSNISGDMGSQMRIGMQVQRMFDNQKILEGNEEVTEVSVSCRDTLEMATIEGARALGLEDEIGTLTPGKRADIITVEQNDFLTAPSHSPIQTAVFQSYPSNINTVLVDGEVVKRDGELTSSLVEEEFDRFVESGRQLVDEAGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4G8</accession>
    <name>A0A3N6P4G8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92839">
        <property type="protein sequence ID" value="RQG92839"/>
        <property type="gene ID" value="EA462_01025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="233" mass="26654" checksum="185CD31175B3DDA0" modified="2019-02-13" version="1">MDLSKLYTILEDEYLWFNHVTNFDDPYEGVYSEKTAKKIAEMHVDWFDLSEEEALKKAKAGNLSSYVNCWTNSPHQSVALWEKFVEGNKGVAIKTRASNLRAAITDKRRGTDYISFRFGKVEYTDYEETMPRGISAPVYHKRNSFDYEKEYRVVISNYLQSATEGAPTITSDGVEWPYDPGLEISIDVNELVESVYISPTADSYFPDVVGDIVDNSKIDVEVIQSDLFDDPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4K2</accession>
    <name>A0A3N6P4K2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate--cysteine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92889">
        <property type="protein sequence ID" value="RQG92889"/>
        <property type="gene ID" value="EA462_01320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="370" mass="42127" checksum="6DABAC648ABD7935" modified="2019-02-13" version="1">MQLSLELEYWTVDETGTLTSASPVLDRIDDLHAESADPMLEVVTDPCDDVPELRAEVTHRLQEAIEVGREEGCRLVPLSTPLHSGSISTSDGPRTRIQRQVLGEKFNDAIHCAGTHMHIDRIDGAETDQLNLMTALDPAFALVASSTFHQGHRVATCARSHVYRRTCYGDHPWLGRLWPYVEDIDEWYNRIDVTFDRFRQRALAQGVEPSAFDEHFTPEDSIWAPIRLREKYDTIEWRSLDVALPSQVLQLTKDVRDILALVENRHVEIGSRPGVTASTVTVPAFDRLQEHVSSAIDQGLEASTIERYLETMGFDTTTYRPISAELVDKPPMDRQRAQWLRLRYADRLERDVKTLIDERSPMRTPVTQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P503</accession>
    <name>A0A3N6P503_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93109">
        <property type="protein sequence ID" value="RQG93109"/>
        <property type="gene ID" value="EA462_02580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="15172" checksum="8BD711C3AFB079F6" modified="2019-02-13" version="1">MPTRILVPVDGSKRSDDALEYAIETFPDAAITVLHVVEAGQGDLGTFSGMTGDVPDDEPELQHSTAVLESARERGEKLGASIETERGRGRPDRLIVKRAEEGDYDMVVIGSHGRDGVARVLLGSVAEKIARRSPVPVLIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6A3</accession>
    <name>A0A3N6P6A3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome C biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91275">
        <property type="protein sequence ID" value="RQG91275"/>
        <property type="gene ID" value="EA462_04605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="14"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="224" mass="22864" checksum="CFAEB1A4441624DB" modified="2019-02-13" version="1">MIDTTLLPTIVFALTAGIATFFSPCAYPLLPGYVGFYVSQTEQKEASLAGALSRGLVAGTGVLVTFGVLLGAAFWIGHSRLSNVVLFEPIVGALLVVFGILVVLDRAPSLSVALPKRRSGVFGFAIFGVGYALAAAGCVAPLFGAVIASAISQPPMSAALVLGTYVGSVVLLMVSLTVATGMGVLASVGRLAAYGDRLKRLAGAIMIVAGLGQLYLAIFVLDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9E1</accession>
    <name>A0A3N6P9E1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92845">
        <property type="protein sequence ID" value="RQG92845"/>
        <property type="gene ID" value="EA462_01060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="315" mass="35663" checksum="02BC62F404D25048" modified="2019-02-13" version="1">MKVSVVICTYAMDRYDVFSDCVDSVLAQTYDPLEVVVVVDGNDDVFDRVRADYGDSAGVVLHCNDDNQGISYSRTRGAEIATGEVVAFIDDDAVAEADWIEELARVYDETDAIAVGGHAKPDWITEKPDFFPAEFYWLVGCDERGMGEHMEELRNTYGSNISFRRNVFLNVGGYDENTGRKGDRHVQAHEAPVCIRMANRYGKGVIYNTDAVVNHKLFDYRGEFRWLVFRSFWQGYSKRIMDVLLPEASGDKNDYLKQLMVQFVPDRLSELFRRPSVPKAKQLIAIFVFTAAVGFGYLYGLLEVDRAELKASTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIB4</accession>
    <name>A0A3N6LIB4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prefoldin subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">GimC subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pfdB</name>
        <name evidence="10" type="ORF">EA462_15695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87074">
        <property type="protein sequence ID" value="RQG87074"/>
        <property type="gene ID" value="EA462_15695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00307">
        <property type="entry name" value="PfdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012713">
        <property type="entry name" value="PfdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02338">
        <property type="entry name" value="gimC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="9"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG87074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="131" mass="14230" checksum="8D5BE14F3BF28D69" modified="2019-02-13" version="1">MQGNLPPEAQEKIEQLQDLQETAQQVAVQKQEAESTLTDAENALDELENVDDDTVMYRQVGELLVETEYDEAEDELDDKVNSLEIRLETLEKQEDRVQQQFESLQEELEGLLGGGMGGGPAGPGGPGAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJS6</accession>
    <name>A0A3N6LJS6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aconitate hydratase AcnA</fullName>
            <ecNumber evidence="8">4.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acnA</name>
        <name evidence="8" type="ORF">EA462_10355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88798">
        <property type="protein sequence ID" value="RQG88798"/>
        <property type="gene ID" value="EA462_10355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="6">
        <location>
            <begin position="78"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="7">
        <location>
            <begin position="714"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG88798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="918" mass="100306" checksum="DA236CBCE4D6E6D2" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKJ4</accession>
    <name>A0A3N6LKJ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89178">
        <property type="protein sequence ID" value="RQG89178"/>
        <property type="gene ID" value="EA462_12490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="99" mass="10965" checksum="CF16070C2C4555A0" modified="2019-02-13" version="1">MIRRTLCSEMVAACLGLAGCTLPTRSEQSTEVNGSADASGELTAASTDDARIVDSRGPTFAATPLEDLPSYDDRDSEQPTDWYFEHRDRPFVIAYYQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LL74</accession>
    <name>A0A3N6LL74_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acylamino acid racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87810">
        <property type="protein sequence ID" value="RQG87810"/>
        <property type="gene ID" value="EA462_13130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="159"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="41950" checksum="22F69FCFAC3C8189" modified="2019-02-13" version="1">MEITDVEAYAVNMNVIDLEDGGLSPYVTNHGAVEDVDRILVKVDTDEGISGWGEMRVFLSPETTVTIIEDGVAPIIEGHSPFEVESLRRLLFIEYTNIDMFFSAVEIACWDIVGKSLEKPIYELLGGWTAPGVTTRQIEQDYDYEQRVDVAYCVGILSPEESRAHARKALEGGHSVLKTKAGRDWKADVDRIIAMDDEVDGALEFRLDPNQGWRLDEAVRVGAALSDAGVYLQYLEQPIRVDSHESLARLRERTCQPIGPNEDTYIAHNLQNLIESGALDVAVVDMTPAGGISGVRQLAAIAEDAGVPLAHHCAFDLGIRTAAIVHTVSGVPGFTLPPDSVYYAWEDDVIEDPFTVEDGALPVPQEPGLGVSVDEQKVAEYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLD1</accession>
    <name>A0A3N6LLD1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87900">
        <property type="protein sequence ID" value="RQG87900"/>
        <property type="gene ID" value="EA462_13640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="201" mass="22501" checksum="5F658C7C179A598B" modified="2019-02-13" version="1">MDATDDAACGRWDNSDCTGTPFCPPRCPRFADRDGEAMIVELAQQADYYPLVSMYDEMGAEQQTMGIPPLTRGRVESWIERLYRHGWNLIAKHDGRVVGHVGVTPTESDEPEFVIFIAPEYQNRGLGSELMKHVIAYASDRGYDALTLDVARENRRAITVYRNVDFEVTGTNASEVEMVLSLDKPIAKESQLPPGKRDQCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLQ9</accession>
    <name>A0A3N6LLQ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAA hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88100">
        <property type="protein sequence ID" value="RQG88100"/>
        <property type="gene ID" value="EA462_13750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="244" mass="26669" checksum="9CBFBC90CA9454EC" modified="2019-02-13" version="1">MRRVRFETDEQVRNGHYESGEIVADSETYDVDEVTILPPCEPTKIVAAGKNYHDHIAEMKEKGIGTGEIPDFPFFFFKPPSSVIGHGGIIAYPDGGELVHYEGEVGVVVGERCRNVATDDAIDVLAGYTALNDVSHRDWSGKEEQWVRHKGRDTFCPVGPFLQTDVESDIGVQTHVNGEKRQDSRTTEMVFSIAELVSDASQYMTLEPGDVIATGTPSGVGQISPGDTVEVTVEGVGTLRNDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM43</accession>
    <name>A0A3N6LM43_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90038">
        <property type="protein sequence ID" value="RQG90038"/>
        <property type="gene ID" value="EA462_08530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="55" mass="5693" checksum="84541918C56E4040" modified="2019-02-13" version="1">MSNDILVAGEALVDFIPVRPGPISAVEGFRRRAGGAPANVAVGLDALAEIVVHWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM92</accession>
    <name>A0A3N6LM92_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90193">
        <property type="protein sequence ID" value="RQG90193"/>
        <property type="gene ID" value="EA462_09400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="178" mass="20071" checksum="ADE48BE2BD182613" modified="2019-02-13" version="1">MGILDLMLGTSGPGEQGVDGKSYTLSKATHDFVYPVAVRRDELEAFVRLLEDEEAVPSLEENTDELQDALDSVLEDHDIDATELAERGRKPRLEAEPVIEHWREQLSGDLGVVYARPGTYPVLLTFVKRCTRRDEDEDDPFELPETFSDAAGLLKRLEEATDRQYRAVVHTDLLANRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMM9</accession>
    <name>A0A3N6LMM9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86805">
        <property type="protein sequence ID" value="RQG86805"/>
        <property type="gene ID" value="EA462_16475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="217" mass="23476" checksum="86575FE07647A488" modified="2019-02-13" version="1">MVETVIFDLDNTLVVFDRDRNARLAATTDEVGAPPLTNEEYLSVHKKYLTNETREPIFAELLADQDDIDPAAAAAAYRDVTAEAILPLDGVVAMLEELSHEYSIGLLTNGPERAQREKLATLGWDNLFDEALATGEIQSGKPDSLSFKTILNELAVSPEEAVYVGDSIESDINGATNAGLRAIQVLYDGGPDPHSRAAGHVEQNQIAEELPSLISTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMP8</accession>
    <name>A0A3N6LMP8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Replication factor C small subunit</fullName>
            <shortName evidence="6">RFC small subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rfcS</name>
        <name evidence="8" type="ORF">EA462_09215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90378">
        <property type="protein sequence ID" value="RQG90378"/>
        <property type="gene ID" value="EA462_09215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01509">
        <property type="entry name" value="RfcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023748">
        <property type="entry name" value="Rep_factor-C_ssu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="49"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="329" mass="36449" checksum="6676BA7936973133" modified="2019-02-13" version="1">MSEADAETVEGTPGRTEVWIEKYRPQRLADIKGHEDIVPRLQRYVERNDLPHLMFAGPAGTGKTASAQAIAREVYGDDWRENFLELNASDQRGIDVVRDRIKDFARSSFGGYDHRIIFLDEADALTSDAQSALRRTMEQFSNNTRFILSCNYSSQIIDPIQSRCAVFRFTELADGAVETQIREIADVEGITVTDDGIAALVYAANGDMRKAINALQAAAVMGETVDEETVFTITATARPEEVEAMVDHAIGGDFTAARAALEDLLTDRGLAGGDVIDQLHRSAWEFEISEQATVRLLERLGEVDYRITEGANERLQLEAMLASLALEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNT2</accession>
    <name>A0A3N6LNT2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-keto-5-aminohexanoate cleavage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87847">
        <property type="protein sequence ID" value="RQG87847"/>
        <property type="gene ID" value="EA462_13350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="313" mass="35031" checksum="C6142DFFBBD0B819" modified="2019-02-13" version="1">MRSFDKVIVTCAVTGAIHVPTMSPYLPIEPEEIAEEAIAAAEAGASIIHLHVRDPETGEPVTDLELFRDVAGRIHDACDVIIQPTTGGAPTMKPEERIRVVPELEPEMASCNMGSINFGLYPILEKYDEFEHDWEREYLEGSRDLIFHNTFEDLDTILPIFNEHGTKPELECYDVGHLYNVKHYVERGLLETPLHFQFVMGIHGGIGPDVENLTHMVHIADKLFGDEYSFSVLGAGRHEFPRAIQAVEMGGHARVGLEDNLYLESGKLAKSNADLVEKVVRLTHDLTGREIATTSETREFFGLKGRKRTNIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNV8</accession>
    <name>A0A3N6LNV8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87877">
        <property type="protein sequence ID" value="RQG87877"/>
        <property type="gene ID" value="EA462_13520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="73" mass="8208" checksum="2766B8B4314EF78C" modified="2019-02-13" version="1">MTSFRSVVRRGHRTLTCLETISNEPDVATSLISTRSLPRFQRDGSAPSSESCRVPIRPSTFRENLDQLSLITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPM8</accession>
    <name>A0A3N6LPM8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TrmB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91433">
        <property type="protein sequence ID" value="RQG91433"/>
        <property type="gene ID" value="EA462_05530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="268" mass="30064" checksum="128E11786D0A693A" modified="2019-02-13" version="1">MASLRDLGLSEYEARAYRALLNTGPTTAKELSRASDVPMGRIYDVLNSIEQYNLVRSQTASRPKKYVAVEPSTALDRLLDDKRRELEEKAEQYESIVDDLSDELDAADPIEEQFWTAAVGPEETTDLLLERLAAADDHIVMVAADPVPERDMQTVSEDVTEELENALDRGVSVDVLMTREMIGTLSENVGERYRRTLQGRDDFDVRTNDDVTGSFNLIDDVELCIQVPNPLSSGDAFGMIDLKDPEFAATVHEEFVPRWTEAEPLEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPM9</accession>
    <name>A0A3N6LPM9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88834">
        <property type="protein sequence ID" value="RQG88834"/>
        <property type="gene ID" value="EA462_10560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="169" mass="19322" checksum="3197D368A062C10F" modified="2019-02-13" version="1">MTVTIEVPPRYARLVRKKAKERNQSFEEYEDWDNQSNTWGVDPESRHMIGLMGEMAFAIYADLQINTEVLGWSDEGVDFEISIEGIERTVDIKTSQKEPYALPVKKSRVNSDYYVLAHLQDTTVTFLGAATKEMVLDRDPKKSKFGHYNYQVPVSELNPLPDSESIVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPY3</accession>
    <name>A0A3N6LPY3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91608">
        <property type="protein sequence ID" value="RQG91608"/>
        <property type="gene ID" value="EA462_06560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="7011" checksum="54D8571833665F66" modified="2019-02-13" version="1">MERRQRILVGSIWIAVAALIATTLEPGVTSTSGVIARLFVVALALFLAAVYLLDPWDLISRKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ17</accession>
    <name>A0A3N6LQ17_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MoaD/ThiS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91643">
        <property type="protein sequence ID" value="RQG91643"/>
        <property type="gene ID" value="EA462_06760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="93" mass="9970" checksum="5E4D5A633A87B072" modified="2019-02-13" version="1">MSTEWKLFADLAERAGDKRVTVDASAGDTVGDALEQLVEGRAELEARVLEDGELRSQINVLRNGTNVLVEEDGLETVLEGDDELALFPPVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ80</accession>
    <name>A0A3N6LQ80_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91723">
        <property type="protein sequence ID" value="RQG91723"/>
        <property type="gene ID" value="EA462_06190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="219" mass="23690" checksum="1CDFD2DEDAC1726B" modified="2019-02-13" version="1">MLQAIVFDLDYTLAVPDRDRATILRETIDATGAPEVTRDEYLEAHRSNLTRETREPIFADLLADRESDVDPAELAAVYRETIANTIQPLSGVEAMLADLRAEYRVGLLTNGPIRAQRDKLDVLGWNDAFDAVFVTGELEAGKPDPRAFEAIAGELGVDPAAAVYVGDEVEADVSGATNAGMRAIQVLLEDGPDPDQRAVAYVPQNELATALPDVVADLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRV2</accession>
    <name>A0A3N6LRV2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps11</name>
        <name evidence="7" type="ORF">EA462_04135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located on the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91187">
        <property type="protein sequence ID" value="RQG91187"/>
        <property type="gene ID" value="EA462_04135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019961">
        <property type="entry name" value="Ribosomal_S11_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03628">
        <property type="entry name" value="arch_S11P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="129" mass="13331" checksum="670F8B91A9194C99" modified="2019-02-13" version="1">MSQDDDKWGIAHVHASFNNTVMTVTDLTGAETIAKSSGGTAVKQNRDEASPYAAMQMAESVAEEVKAAGITGLHVHVRGPGGNLQKSPGPGAQATIRALARSGIEIGRIEDVTPIPHDGSRAPKGKGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSA0</accession>
    <name>A0A3N6LSA0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91407">
        <property type="protein sequence ID" value="RQG91407"/>
        <property type="gene ID" value="EA462_05395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="193" mass="19834" checksum="4DB11EA46CCE09D2" modified="2019-02-13" version="1">MGWNAGLEPTGQFAHVWVLETYRSLTPVERIGGQFVGALVAAVVLLGLVQEHSSRAIAKSRRSPIISSCLGFPSLLVVLTISSTGYLILGSSLGTFFGVIFVVFGITVIPVAAVVGLVAIGQSMAARFGRDTLWFGVLCGSLVCGLAGLSLAVTVVLVGTATTLGLGTLVRILLGPGGTTSPEDRSVPPANKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSB7</accession>
    <name>A0A3N6LSB7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear transport factor 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92798">
        <property type="protein sequence ID" value="RQG92798"/>
        <property type="gene ID" value="EA462_00785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="107" mass="12506" checksum="492A889A8E2F8C14" modified="2019-02-13" version="1">MEPTTLVRQYYDALDDHEYEALEEVLSTGFVQHRPDRTFEGRETFVRFMRDERPNPNTEHELDAIVDDGDQVAVRGRLIESGTTLFAFADFFDLSDGRIVRLETYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSE7</accession>
    <name>A0A3N6LSE7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92843">
        <property type="protein sequence ID" value="RQG92843"/>
        <property type="gene ID" value="EA462_01045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="467" mass="54300" checksum="CB8A2A7775209070" modified="2019-02-13" version="1">MNRDELLAELTEDILTYAMHGSFPQGEVAKSIKPKTLDERFEEYELLLDLHFVLQQEVVDFVEALPERLRSIRTETRNVSRTRRGTVDGRINWGATVKQRYSEHPRDRSIFVCDNRSENYDIPENLVLKKLVSVIHRTTREAEEYLRQDYDWVTDTWKENGELIDDLQRVVERNVHIRRIRKPDAYEPTERMLTTAANSRHEIYQDAAKLLRTRRRLFRGESDAIRRLLDETAIAPDDTETLFELFVLFRFVATLEDLRKTRPNFQTIRSGRQEVARFEGETELVLYHDTAGGDQGLNFVAVPDEDKDEKALSRTEQVQLVAQEVAENYFGKKYRNTTGRPDVIVLEIIAGDDDREYLITEVKNSTREKTIRQGIKETLEYIAFLRVNEEFVFGSREDADVRDVDVADIDESYFGDGWNGMLVVQDLDRETSSLDEQGDNEIVILQASELRDNLEPVLLQAVDGLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSF8</accession>
    <name>A0A3N6LSF8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NfeD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92868">
        <property type="protein sequence ID" value="RQG92868"/>
        <property type="gene ID" value="EA462_01190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="217" mass="22511" checksum="46A8D2C0D4F7783A" modified="2019-02-13" version="1">MLDVLFGNMPLVLLSAGLILMALEALSPGAHLIVIGVALVGAGLVGVLFPTAASPFILAALTLFIGLIATYVYREFDFYGGKGTPQTSDSGSLAGSTGYVTEPITTREGEVKLDEGGFAPFYSARTTSGSIEEGEEIIVLDPGGGNVLTVEALSSIADDEIDRALAEETPADGDSASEPSSDVHEDSELPSSRDESTVTDNDTDESTATERETEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSM1</accession>
    <name>A0A3N6LSM1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TrkH family potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_01705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92958">
        <property type="protein sequence ID" value="RQG92958"/>
        <property type="gene ID" value="EA462_01705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006247">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG92958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="509" mass="55153" checksum="9AE9D32FB389A7AD" modified="2019-02-13" version="1">MRVRVDWRSSCSLTGTVLKWLSVPLAAPALLAVLDGTDPLPFLIAMAVTIVSGLALERLSDDPDLGQRESLLMVALTWFAVAIVGAIPFVLVGLGADGNSSFSGVVNGPVNAFFESMSGLTTTGATVMNAWDFENQSRATLLWRQLIQWLGGLGILIVAIGLLSHLMVGGAQLMETETQTRNVRKLRPHISETARLIWQIYVGITVLAVAVFYALYLLGLAPNMTLFNAVSHALTSVATAGFSPEAESIGAFSPIVQWSIMPFMIIGSTNFVLLYYLSRGEFTRPFESEELRFYLGTLVFFGVVVVSILAFDPEIDMGLEATVRHGLFNVVSLVTTTGYASTNFDLWTPGAKHALFLCMFLGGMAGSTTCSIKSLRWLVVFKAFRRNLFTAIHPNAVRPVRVSGGVVDEETINDIFGYVMLALVIFFALTIFLVVDAARAGEFVSEFEALGAAASIFLNIGPAFGMAGPMDNYAGFPASSRAIMIVMMWIGRIEIVPVLVLLLPAFWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSW3</accession>
    <name>A0A3N6LSW3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphate ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="8">3.6.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstB</name>
        <name evidence="8" type="ORF">EA462_06830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.27" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91657">
        <property type="protein sequence ID" value="RQG91657"/>
        <property type="gene ID" value="EA462_06830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="40"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="285" mass="31098" checksum="2F7D8AACC5F7B729" modified="2019-02-13" version="1">MTANGGPRTVSKSGTDDAEIESVTANDVPLGSPRISDPVIESRDLDVYYGDDQALHGINMGIPERKVTALIGPSGCGKSTFLRSINRMNDLIDIARVDGELRFHGKNVYDEDVDPVALRRKIGMVFQKPNPFPKSIFDNVAYGLRVQGKDDDIEDQVHSALERAALLDEVEDQLDSSGLDLSGGQQQRLCIARAIATDPEVILMDEPASALDPVATSKIEDLVEELSAQYTVVIVTHNMQQAARISDTTAVFLTGGNLVEFDDTNKIFENPESDRVEDYITGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LTC9</accession>
    <name>A0A3N6LTC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_03195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93328">
        <property type="protein sequence ID" value="RQG93328"/>
        <property type="gene ID" value="EA462_03195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="378" mass="40206" checksum="7408EA4EE77475B0" modified="2019-02-13" version="1">MGESPDRSRRYVLAGVVGLLGILTAAILLEVLGTILFALTVAYVLVPVQRWLVRRGLSEWIGALAATLLGFVSIVAVFSPILLTLYFRLDEVIGIVEELPAEIPITAFDVTYTVEVADVQRSAIDLLTDAAFSLASALPVLAIKFALFVILLFALVLKGDAAARAAVAPIPHEYRDIAYALGTRARETLYAIYVLQLATSVATFIIGYPLFWALGYDMALTLALIAAILQFVPIIGPSLLVVPIALYHVAAGELLAAVLVGVLGVALVAWFPDIAVRPRLARRSANLPGSLYFVGFTGGLFTLGPIGIVVGPLIVAVFVEAIDLLADEVNGDVDIASLLEADDERDLDATTDGDHSPTDVDSDTETTFEESGSRTAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LU89</accession>
    <name>A0A3N6LU89_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome segregation protein SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_03715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91114">
        <property type="protein sequence ID" value="RQG91114"/>
        <property type="gene ID" value="EA462_03715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="13"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="366"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="661" mass="75843" checksum="606E467CC237BF29" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUP1</accession>
    <name>A0A3N6LUP1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_04665</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91284">
        <property type="protein sequence ID" value="RQG91284"/>
        <property type="gene ID" value="EA462_04665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="166"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="398"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG91284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="458" mass="48085" checksum="1357AA28F0FDE790" modified="2019-02-13" version="1">MTLFGTAGIRGPVEEITPSLALAVGQAAGEPGESFVVGRDGRETGTALAAAMEAGLESAGSDVYRTGEVPTPTLAFASSGRRGVMITASHNPPADNGIKLFVDGIEYDRDAERSIEAAVDSSDSGAAPWTEWGRSGRLEVLSGYRDAVSTYVRERFGDGPDGDVLSGLSIAVDCGNGVGSLATPQVLDRLGADVVALNANVDGHFSARESKPTPETLAEFSDFLAAGSFDLGVAHDGDADRLVVLGPDGGIIHEDTVLAVVAAHYTAESDARDPVVVTTPNASARIDDRVRAAGGRVERVRLGGLHEGIERERKAGDEGSAVVFAAEPWKHIHTAFGGWIDGVASAATVAALVADAGDTDTLRAPVTERPYRKVSVDCPDERKDDAMALLERRLPDSFPEATVDTDYGVRLERPDASWVLVRPSGTEPYVRIYAESDDIDELISKTNDVVETAVTDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV53</accession>
    <name>A0A3N6LV53_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91534">
        <property type="protein sequence ID" value="RQG91534"/>
        <property type="gene ID" value="EA462_06125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="124" mass="14169" checksum="32F03A95E7BF2F28" modified="2019-02-13" version="1">MSIDRETFERSSEEELEELSSVDRVLGFLATNDDRAFKARTIAREIELDVGAVSTALTRLKSRGLVEHKGTYWAVTSDERRLTSHEGYARATALFNEQFGEEDREEWKEHAPDEPHPSVADEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVY5</accession>
    <name>A0A3N6LVY5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8 10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="5 8 10">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisA</name>
        <name evidence="11" type="ORF">EA462_01700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="5 8 10"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92957">
        <property type="protein sequence ID" value="RQG92957"/>
        <property type="gene ID" value="EA462_01700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG92957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="243" mass="25190" checksum="21EAA0C3009B1141" modified="2019-02-13" version="1">MTAFPEFEVIPAVDVQDGEVVQLVQGERGTERTYGDPVEAAQRWIDAGAETLHLVDLDGAFDGERGNAEAIDSVLEAVDVPTQLGGGIRTVEDATGLLERGLDRVILGTAAVETPEIVDEISAEHPDSVVVSLDAKDGEVVVEGWTEGAGISPVEAAERYEELGAGAILFTNVDVEGKLEGVATEPVRMLVEATDVPVIASGGVATLEDVRALSDAGAAAVVVGSALYEGRVSLAEAQAVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWQ5</accession>
    <name>A0A3N6LWQ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_02955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93317">
        <property type="protein sequence ID" value="RQG93317"/>
        <property type="gene ID" value="EA462_02955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="109"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG93317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="716" mass="80960" checksum="CD5EF4A6218EE90C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXE9</accession>
    <name>A0A3N6LXE9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_16425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86721">
        <property type="protein sequence ID" value="RQG86721"/>
        <property type="gene ID" value="EA462_16425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="28483" checksum="7532EA216B2581EC" modified="2019-02-13" version="1">MSQIELRDVEKVYNSEVVAVDGVTATIESGEFVSILGPSGCGKSTLLFMIGGFIERTDGDILVEGETVHEPGPDRGMVFQESVLYPWLTVEDNIGWGLKIQGVPRDERREAVQEFISMIGLEGFEEAYPSELSGGMQQRAAMARVLVSNPNVLLMDEPFGALDAQTREVMQNELLDIWQRTGQTCVFVTHSIDEALFLSDRVLVLTARPASIKLEVDLTEFERPRDSSLKQSEAFRSRREEVWQTLQEEVAIAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY61</accession>
    <name>A0A3N6LY61_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV pilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87041">
        <property type="protein sequence ID" value="RQG87041"/>
        <property type="gene ID" value="EA462_15485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012859">
        <property type="entry name" value="Pilin_N_archaeal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07790">
        <property type="entry name" value="Pilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Pilin_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="148" mass="15573" checksum="5E174E245BFF0A69" modified="2019-02-13" version="1">MDAKLIQRKLVGEEQERAVSPVIGVILMVAITVILAAVIAAFVLDLGGSVGQEAQAGVSIDVDESAEEVSVEITSLGNSNYVDLSSSEWGDGMDGTEDNVTNMDVGDTVTLEHDKAPQDINESGTVSAVAVIEESETRTSVASEDWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY99</accession>
    <name>A0A3N6LY99_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92824">
        <property type="protein sequence ID" value="RQG92824"/>
        <property type="gene ID" value="EA462_00940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="172" mass="19927" checksum="1BF214726094A58E" modified="2019-02-13" version="1">MTDNTRREGPPPFDRPFEGEDTKQRVYGTVLHAREPMTAAEIAEQADCSAESARTHLSFYADLGIVIRHEGRPVRYERNDDYFEWRRVNELARENTVDELQARVSALTDRIEEYRDEYDVDSPAEVDVLEFDAARIDDVYVELGDWATAIEERRHHERARRKAASSTTPSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYV6</accession>
    <name>A0A3N6LYV6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93064">
        <property type="protein sequence ID" value="RQG93064"/>
        <property type="gene ID" value="EA462_02325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="69" mass="7864" checksum="D61F1D08777A4BB7" modified="2019-02-13" version="1">MTEYTTVSIPKDLAGRVEETIEGTSFQSTSDLVRFLLRSIVIQHQKEGELTEAEFEEITEQLRGLGYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ01</accession>
    <name>A0A3N6LZ01_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87943">
        <property type="protein sequence ID" value="RQG87943"/>
        <property type="gene ID" value="EA462_13860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="164" mass="18980" checksum="A56DD9B810A590D4" modified="2019-02-13" version="1">MNEYTIRHARPDDADDILDLWYEYSDTLSTADERYQHKDDAGEQWRNYFLGKMTDSSRAAVHVADSEEVDGLLGVIEVRIMGAHPIFQLSQHGAVFGHHVRTEHRGNGIEEDLLEEAERWFTDEHDLPFYRVNVLTSNDSLVDLYREYGLDRVETTYEGEGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ72</accession>
    <name>A0A3N6LZ72_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87062">
        <property type="protein sequence ID" value="RQG87062"/>
        <property type="gene ID" value="EA462_15630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="275" mass="29760" checksum="7845B77B50762FF6" modified="2019-02-13" version="1">MVATPLRVVRYGFYAVFDPSKIVGERTAVYAQTRRERVRKAARLVSFYLTNLFVYAVPLTYAGFGATGTVGDPPAIVGELAVIVGSDPATTWQFLSTLIQNCSYLLLFSVLTFGMFHLAVWLTRNSSGFLQSIHTVVYSTGIYLAAIFSFTWYLSTSPAIVVAEGWLIWIQAEFIYTLIDLVGANLELPGGRPDPVDLGGITQSGALALAGLFVSVGYYLYSLYLGSRINHESNRFAALIAVAFVIVSPILFVLGSILLALSAQTGTVAAAFLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ73</accession>
    <name>A0A3N6LZ73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88033">
        <property type="protein sequence ID" value="RQG88033"/>
        <property type="gene ID" value="EA462_14370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="138" mass="14902" checksum="D0A06FED5899BA77" modified="2019-02-13" version="1">MAVLVPIDDSEPAMSAVEHAAETFPDRDLTLLHVISPNTSMYGEAAAFAYDEIVESQREAAEELFEEVTDVFATHDRSVTTETIVGDPARSIVEFAENEGVDHIVIGSHGRSGASRVLLGSVAERVVRRAPVPVTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZB7</accession>
    <name>A0A3N6LZB7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87112">
        <property type="protein sequence ID" value="RQG87112"/>
        <property type="gene ID" value="EA462_15925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="181" mass="20003" checksum="616A4F7EEBDC5863" modified="2019-02-13" version="1">MESDKDVVFIDSSVLISCGRWESTRFQALAREARRRDTVFRISPQVYAEVTGDPALEEYTADDAAVDEALQEGWMKVTESPSYSMSEVSNVMDQARSFIASASDRTEDTVEKADTEIVGLALEILLNDTADRITIVTNDIPLGEAAESLLPQYGFDNEQITWLTGGELAGELAEDFVSEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZX6</accession>
    <name>A0A3N6LZX6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PGF-CTERM sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EA462_10810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
            <location evidence="2">S-layer</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the halobacterial S-layer protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88880">
        <property type="protein sequence ID" value="RQG88880"/>
        <property type="gene ID" value="EA462_10810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030115">
        <property type="term" value="C:S-layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026371">
        <property type="entry name" value="PGF_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026452">
        <property type="entry name" value="Surf_glycop_sig_pep"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04207">
        <property type="entry name" value="halo_sig_pep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04126">
        <property type="entry name" value="PGF_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0701">S-layer</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="754"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="792"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="792"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG88880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="874" mass="93099" checksum="4E4A9D359144DC2F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZY1</accession>
    <name>A0A3N6LZY1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87804">
        <property type="protein sequence ID" value="RQG87804"/>
        <property type="gene ID" value="EA462_13100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="155" mass="16676" checksum="AD5F0BB68D17187C" modified="2019-02-13" version="1">MNRGLVVVDDSETHRTLLEEAGALAAGSGGELVIFTHLSSDEVESNRETIEAISEQEGTTYDSDVALQPSEQFATSLAEETLSDFGIEYGVETRIVEGSELADEIISTAYETDCDHVFLVGQNRSPTGKAIFGDVVQNVILNFDGLVTVNIDEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZY8</accession>
    <name>A0A3N6LZY8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactonase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87814">
        <property type="protein sequence ID" value="RQG87814"/>
        <property type="gene ID" value="EA462_13150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="353" mass="38104" checksum="59A0C7C8431CEF1D" modified="2019-02-13" version="1">MSETVAFVGTYTDTESEGIYRCRVDEPTGSIDDIELVAATDDPSFLAVDPTHRFLYAVNEVDTGAVTAYRITTGNDLEEINRQSIGPADPCYCSLDRTGNYLFVAHYTGGAVSILPIDDDGSVNEPTVTHHSGSSVDPDRQTAPHPHSIVPGPDTDFVYVPDLGTDDVVVYELDRTAGALRERTSVSVQEGAGPRHIEFDSEGSRAYLINELNSTITAFEWDRRSGELSPIETVSTLPNEFDGDNITADIHVHPSGSFVYGSNRGHDSIAVFELTENGLERLEIVETGGSWPRNFCLGSSGESLWVANAHTDTIVGFELVGSDGTIVQIGSSVSVAKPVCLRPVYPRSSDRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M033</accession>
    <name>A0A3N6M033_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87874">
        <property type="protein sequence ID" value="RQG87874"/>
        <property type="gene ID" value="EA462_13505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="258" mass="28169" checksum="5B25BE78F22355EE" modified="2019-02-13" version="1">MLTVRFRSDGTVNTGTVDGHRITTDDATHRIGKVEILPPSEPTKIIAVGKNYRDHVRAILGEVEKEEFPMLFFKPPSSIVGHGDDVIAPESSHFLDYEAELGVVIGERCSSVSEANALEYVEGYTCVNDVTARDWQHTEEQWARAKGFDTFCPIGPVVQTELQESLDITCRVNGEVRQSSNTDELLFSIPELVAEISGHFTLLPGDVIATGTPAGTSAETIPMKEWSDRAGEGALEPGDTVEVEIETIGTLENQVRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M055</accession>
    <name>A0A3N6M055_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87904">
        <property type="protein sequence ID" value="RQG87904"/>
        <property type="gene ID" value="EA462_13660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="263"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="390" mass="40538" checksum="C8B9B2AAAE72F538" modified="2019-02-13" version="1">MTEAYVIGAGQTPFGAFPDESYRSLFQRAYESALESTDGTIDSDAVDEAVIGTLGVGGRQLGLSGPAVTEHVGLEGVPCTRVENACAAGGYAVRQAVQAVRSGMADLVVAGGFEVMTDMSGDLTKYWLGVSGETEWERLTGTTFAGVYAQMASAYMDRYGVDTEPFSRVAVKNHANGAKNPNAHLGFTCSLEDAEGGAPVADPLNLYHCCPTSDGAAVALVASEEFLEDYDGERIRVAGVGASSDPVGLADRDTYTGIPASERAAETAYEMAGIGPDDVDFAEVHDCFAIAEVLAYEDLGFCERGEAPSLLENGTTDLDGDLPVNPSGGLKSKGHPIGATGTGQVAEVFKQLTGNAGDRQLDDPQRGLTHNVGGSGGAAVVHVFERVMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0D8</accession>
    <name>A0A3N6M0D8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88004">
        <property type="protein sequence ID" value="RQG88004"/>
        <property type="gene ID" value="EA462_14195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008727">
        <property type="entry name" value="PAAR_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05488">
        <property type="entry name" value="PAAR_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="103" mass="9881" checksum="56538E969C50976D" modified="2019-02-13" version="1">MGKPAARVGDPTAHGEPLSPGPGSPTVLIGGQPAWRAGSDFASCSIPNSGGAPHGGGTAVPTTGTVLINNLPAARVADQIPEAASDVGPNSIAVGEPTVLIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M256</accession>
    <name>A0A3N6M256_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-archaeol synthase</fullName>
            <ecNumber evidence="6">2.7.7.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">carS</name>
        <name evidence="7" type="ORF">EA462_12555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:25690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="ChEBI" id="CHEBI:58838"/>
            <dbReference type="EC" id="2.7.7.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CDP-archaeol synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.67" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89191">
        <property type="protein sequence ID" value="RQG89191"/>
        <property type="gene ID" value="EA462_12555"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043338">
        <property type="term" value="F:CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01117">
        <property type="entry name" value="CDP_archaeol_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032690">
        <property type="entry name" value="CarS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002726">
        <property type="entry name" value="CarS_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39650">
        <property type="entry name" value="PTHR39650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01864">
        <property type="entry name" value="CarS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="181" mass="18809" checksum="810859B39BD18156" modified="2019-02-13" version="1">MAVLETVVIAFWAMLPAYVPNNAAVLAGGGRPIDGGRTWGGSRLLGDGKTWRGTAAGIAAGLALAAVLTLVADDVSAAIGIDVPAFTPLAALGLAAGAMLGDIFASFLKRRTGRQRGAMFPGLDQLDFVVVSLPLTALIATGWFLEVFTWGVILVVVVLTPILHVTTNVIAYKLGLKNEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2G6</accession>
    <name>A0A3N6M2G6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toll/interleukin-1 receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90000">
        <property type="protein sequence ID" value="RQG90000"/>
        <property type="gene ID" value="EA462_08310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="203" mass="23244" checksum="A15630AC2E20D152" modified="2019-02-13" version="1">MTGEQVYVSHAPGDLEFVQELLSTVRNFPFGIHIALEEVESNSMRARLEGRLVESDVVVAVLTEQASRSRWVNQELGYARSQEVSILPVFDDERYRGGFISDLEGVQIDRERPAKTIFELLSRLRCELEPLGPLSVPNWFIQFPCPSSHCPERVTLDIERSQSKLWNRHRRGHVLTASCDHCRATYSFDPATIGFVRRDERGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2Z3</accession>
    <name>A0A3N6M2Z3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inositol phosphorylceramide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_09435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90200">
        <property type="protein sequence ID" value="RQG90200"/>
        <property type="gene ID" value="EA462_09435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="6">
        <location>
            <begin position="144"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="276" mass="31522" checksum="B4A0D7B76FF609D1" modified="2019-02-13" version="1">MLVRVLVQLVVVVTLLTLVSIAVFVGRYRLRDTRLEWRTRVRAAVPVTALLAIVLLFNSVARQVVPELSWMIGWNVTWAIYDLEGQFILWLQEQATPAVTAYFSFIYIYAYVFMLVFPVIAYFALSNTRPLRELLTAYTLNYTVGLILYVFVIAYGPRNMMPELVDALLYDTYPRYQHLTRQVNRNTNVFPSLHTSLAATVTFLAYRTRDVYPRWFLVATILGVSVAISTMYLGIHWVIDVLAGIVLAYVSVALAAHLVGRWSVGEWIDGRLSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M318</accession>
    <name>A0A3N6M318_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2062 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90230">
        <property type="protein sequence ID" value="RQG90230"/>
        <property type="gene ID" value="EA462_09610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018639">
        <property type="entry name" value="DUF2062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09835">
        <property type="entry name" value="DUF2062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2062" evidence="2">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="152" mass="16468" checksum="4735435923508C64" modified="2019-02-13" version="1">MVTERLALYRDRIRRELTAAFREEHTPHQVASSFAIGIFVTAMPTGGLGIGLFFVLVSMWSWISKPAIFASIAVLNPLVKPGVYLASFQVGATVLGTDPVPIGEDLTETARDAIHQLLVGNLVIAAGLSLTGYALVLHLTRVNRRRTPTVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3K0</accession>
    <name>A0A3N6M3K0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86687">
        <property type="protein sequence ID" value="RQG86687"/>
        <property type="gene ID" value="EA462_16225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="300"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="612" mass="68291" checksum="D70896A84E5D8011" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3Q8</accession>
    <name>A0A3N6M3Q8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Taxis protein CheF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in taxis signal transduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86757">
        <property type="protein sequence ID" value="RQG86757"/>
        <property type="gene ID" value="EA462_16620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007381">
        <property type="entry name" value="CheF1/F2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42201">
        <property type="entry name" value="PTHR42201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04283">
        <property type="entry name" value="CheF-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026802">
        <property type="entry name" value="UCP026802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR026802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="287" mass="31804" checksum="D1EC8CF86B70C6CB" modified="2019-02-13" version="1">MSKSEQKLADVTGKFTQVVREGRKLSDTNWSNGRIVLSNKRMVIVSGDGKTTIPLSKVQSIRGRYDVNQTIAKVSNYISINYGQNVYLISMEEVSSFELELQKAILDGEIVLIKHPAVKGGVVQDASWTKARVKINDGVANFAVENGKLVQIEVDDVGTVESDERTIRSSERPVVEAEHTENGSSVQTYLSGSPQNCAVLKSVLDRGAEKNASQIDLSGKEEEVLMAIYSGVSPFEVPEFLDIDTDDVEEIYERLIELDVLEEIRVRREVALKPRGRNIASEAMNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5J9</accession>
    <name>A0A3N6M5J9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88009">
        <property type="protein sequence ID" value="RQG88009"/>
        <property type="gene ID" value="EA462_14220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="143" mass="16244" checksum="E6AFDE572F8EFD76" modified="2019-02-13" version="1">MHDGDELTARRWSPIDRSARRIGLRQEPMWRPTPNHRSNASSAPRTPGGNDREGDEQQTRSRELPLALTGSVRWNRLVVIRVVERRLEEGFVSCSAPAHGSMLPVHPLTSSPTRTTLGSISHSTRERELHSRVHRNQRFDGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M668</accession>
    <name>A0A3N6M668_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_06160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91540">
        <property type="protein sequence ID" value="RQG91540"/>
        <property type="gene ID" value="EA462_06160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="4">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="222"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="495"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="742" mass="81648" checksum="A17AB48B3B6FD8CA" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6C8</accession>
    <name>A0A3N6M6C8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88846">
        <property type="protein sequence ID" value="RQG88846"/>
        <property type="gene ID" value="EA462_10625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="74" mass="8428" checksum="AA10DA5A96C7F414" modified="2019-02-13" version="1">MITFKKHDTATCPDCGALLVYGTKEEASSWKVYYECNERCGWEQMTGRVPLSAVDHRDDVDDRAREMGDQWAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6N5</accession>
    <name>A0A3N6M6N5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88986">
        <property type="protein sequence ID" value="RQG88986"/>
        <property type="gene ID" value="EA462_11395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="94" mass="10403" checksum="F20F4BD3A93E70BF" modified="2019-02-13" version="1">MMRFGCDMSDKTKCRMCGSHVTPQFRRTHGDENQVAHRCIECDTDERLGEGGAAGQELEKADPIDEPERFNCGFDVPAPVQEVVATDRGESNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8K5</accession>
    <name>A0A3N6M8K5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fumC</name>
        <name evidence="5" type="ORF">EA462_07190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89796">
        <property type="protein sequence ID" value="RQG89796"/>
        <property type="gene ID" value="EA462_07190"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="3">
        <location>
            <begin position="15"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="4">
        <location>
            <begin position="410"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="326"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="471" mass="50585" checksum="C16AFC00A52568C5" modified="2019-02-13" version="1">MGDEDDYRLEQDSLGEMRVPTDAYWGAQTQRAIQNFPISGISFGRRFIRGLGVVKKAAAQANRDLDLVDDDVADAIVEAADEVIAGEHDDQFPVDVFQTGSGTSSNMNANEVIANRAAERMGADIGDRVVHPNDHVNYGQSSNDVIPTAMHVASLEAIEKDVIPALDTLREALEEKESEFDDVVKTGRTHLQDATPVTLGQEFGGYRTQVEKGLARVDKVREHLAELALGGTATGTGLNTHPEFPGRAAEYITKETGVQFREADNHFEAQAAHDAMSEAHGALRVVAGSLNKIANDLRLLASGPRNGLGEIEQPQNQPGSSIMPGKINPVVAEAVNQVHKQVVGNDAAVTAGAAEGQIDLNLYKPVLAHNFLQSAELLANASTVFADRFVRPLEANSEHCAGAVEQSMALATPLNVHIGYDKASEVAKIATNEGKTIREVALEKGYLDEDEADEVLDPAKMTERGILGQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8L4</accession>
    <name>A0A3N6M8L4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89806">
        <property type="protein sequence ID" value="RQG89806"/>
        <property type="gene ID" value="EA462_07240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="496"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="590" mass="64050" checksum="02167B98E0F40C05" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8Y6</accession>
    <name>A0A3N6M8Y6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89946">
        <property type="protein sequence ID" value="RQG89946"/>
        <property type="gene ID" value="EA462_08020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043858">
        <property type="entry name" value="DUF5820"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19137">
        <property type="entry name" value="DUF5820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="131" mass="14991" checksum="02A6DDFEA4F9F685" modified="2019-02-13" version="1">MTDETVVPDGWVVWSEGEDGRLVLAYRPDVFNGEAFPAACLPTLYLTHGRRTRRPGRNPTDTTAGDDWFVTFYLEPDVTVDGSARFSTRADALEHAIDLARRFADGEVDYRERYQVPRDRYFDRLDDLVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MA71</accession>
    <name>A0A3N6MA71_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HTTM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_03170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93210">
        <property type="protein sequence ID" value="RQG93210"/>
        <property type="gene ID" value="EA462_03170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008488">
        <property type="term" value="F:gamma-glutamyl carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017187">
        <property type="term" value="P:peptidyl-glutamic acid carboxylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007782">
        <property type="entry name" value="VKG_COase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05090">
        <property type="entry name" value="VKG_Carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM" evidence="6">
        <location>
            <begin position="23"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG93210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="533" mass="60577" checksum="F1C222C9483A1A6A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBD6</accession>
    <name>A0A3N6MBD6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF460 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92771">
        <property type="protein sequence ID" value="RQG92771"/>
        <property type="gene ID" value="EA462_00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007408">
        <property type="entry name" value="DUF460"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40707">
        <property type="entry name" value="PTHR40707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04312">
        <property type="entry name" value="DUF460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="657" mass="74021" checksum="AE3DBB2AC6C187BA" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC79</accession>
    <name>A0A3N6MC79_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91306">
        <property type="protein sequence ID" value="RQG91306"/>
        <property type="gene ID" value="EA462_04790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07719">
        <property type="entry name" value="arylsulfatase_AtsA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044094">
        <property type="entry name" value="AtsA-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="244" mass="26792" checksum="4D47EF9DE40D092D" modified="2019-02-13" version="1">MRVTFLGTGSAMPTGERVQTGLLVQESGRTLLIDCGSGVLHRLQQSGVGYESVSTVLLTHHHLDHVADLLPLMKARWLAGEEHLEIVGPQGTKGLVDGLLSVHEYMEGRLDLQVREIVAGEFSIADFDVSAYETRHSLPCLAYRFDDRFTFSGDSEAFAGLANFADGSGILVHDCSFPDDVDVSNHPTPDSLGRELADRDIGRVYLSHLYPHTDGRHEEMLESIGAHYDGDVRFAEDLTTVTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCH2</accession>
    <name>A0A3N6MCH2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation initiation factor eIF-2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91426">
        <property type="protein sequence ID" value="RQG91426"/>
        <property type="gene ID" value="EA462_05495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="283" mass="30893" checksum="7022E1F86BA7B1DF" modified="2019-02-13" version="1">MIDETVEQIQEMQTHSSSVVAIRATRALEDLTDREFATVEEYVRSLERNATVLRRANPSHATLQNAVRQVVEDVTTADLDSVEDAQNLTRERIDAVVSKVESGKRLAAENAATHLEDGATLLTHDYSSTVIGALEKATEAGKSFDVYVTEARPRYIGRKTARALAGIDGIDPTLITDSANGVYLEECDRVIVGMDCIVDETLYNRVGTLPIAATATQFDVPVTVLGSASKIISEGFVFENDFRSGIEVMSEPTEGFDVENPAYDATPVSLLESVITDDGRREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGM4</accession>
    <name>A0A3N6MGM4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93116">
        <property type="protein sequence ID" value="RQG93116"/>
        <property type="gene ID" value="EA462_02615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="352" mass="38297" checksum="F9FE98361A156823" modified="2019-02-13" version="1">MTDSRLTREMTVSAPDRCRLQRSNDRGISTVVDVSLCLLLITASIAVLAVFLADERAVHDPTIADETAQTIATSTTTIEYSVRSVERRDDTGVFDDAAYDDGRYDRVEHGSLAQLLAAAALSNVSLDGEPLSHAGLEFRDAVDANVRSELAGANDDVHLLARWEPYPSASIRGESTAGDRPPASADVSTVTFSVSSGFPSVSDDDLEGTYDAENGSFERTAEPIADAILDGYFPHESTTVALQGSDLERDLTRYEYLRFESILDLDRDLEHNELNRTAVDIAGANEKLAANLTETIAADLEETFEPEIAEIESELEAEYPADEEPVTSAVDDLVRSSVATDEVLITVRVWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGT0</accession>
    <name>A0A3N6MGT0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93186">
        <property type="protein sequence ID" value="RQG93186"/>
        <property type="gene ID" value="EA462_03020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="384" mass="40267" checksum="E8991D392DF75A50" modified="2019-02-13" version="1">MSDHDFVSGGKPIAIDRGEGPFLYSTDGTEYVDAGASFACTPLGHSHPAVVDAVKAQVSKVTFVDSSYPVQSREDAYAALVAATPDGLDQAWFCNSGTEANEAALKFARSATGESKIVAATRSFHGRTMGSLAATWKDEYKKPFEPLAGDVEFVPYGESEALADVVDDETAAVILEPIQGEGGINVPPAGYLETARELTDETGSALVFDEVQTGMGRTGSMWACENAGVTPDVLSTAKGLGNGLPVGAVAVRDWIADGAASHNATFSGGPVVSAAVHATVSTLVEEGWPDHADEIGDYLVDELEATLGDEVREIRGDGLLIGIELKRGANRVARDLAMDHRILALPAGRTVLRLLPPLVIGEDEADRVVDALTEIVVPDAETES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRT0</accession>
    <name>A0A3N6MRT0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86983">
        <property type="protein sequence ID" value="RQG86983"/>
        <property type="gene ID" value="EA462_15135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="161" mass="17240" checksum="39D82F5CDAB7D7F1" modified="2019-02-13" version="1">MSVQQQRRVSLVVGAVFLLVFAWSLWISFEVLAAEPLSGTVAAMLAGGLAMVLGGLAFLVAGLRERVTVAGRTLEWWQLQSVGFVCLGLYMIVSGLAQDSLLSFYALLTAAAGIGFVAFGIQRLRNGLPEETEPSMRQVATVVVGTMVGFLLFTIVAIWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSV5</accession>
    <name>A0A3N6MSV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87845">
        <property type="protein sequence ID" value="RQG87845"/>
        <property type="gene ID" value="EA462_13340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="101" mass="11207" checksum="7EEFA3E4A035E489" modified="2019-02-13" version="1">MFHVVEHGTRRRTTGLGAATTIRVYTASSRSLLPSRTSIRFSIGFRSPLSRCGMGYRLSLRPLQATARRTIPRIRADDVHPGFAVGGNENRSPSRVTRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MT90</accession>
    <name>A0A3N6MT90_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88005">
        <property type="protein sequence ID" value="RQG88005"/>
        <property type="gene ID" value="EA462_14200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="705" mass="74025" checksum="D572EAB843607F15" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MV36</accession>
    <name>A0A3N6MV36_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89282">
        <property type="protein sequence ID" value="RQG89282"/>
        <property type="gene ID" value="EA462_11715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="40"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="234"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="317" mass="34634" checksum="A1558FDE179BD913" modified="2019-02-13" version="1">MNAAEAARTCDAVFGEIQTAVVGEHDRFETILTAVVGQGHVLLEDVPGTGKTLTARTLATALDLEFSRIQFTPDLLPADITGTHVYDEHAGRFEFEAGPIFANVVLADEINRAPPKTQAALLEAMGEKQVSTGGETRTLPEPFFVIATQNPVEQEGTFPLPEAQIDRFMIKTTMGYPDRDGELELLDRRASRRSRTPNVSPVIDRESVLSLQSVPESVAVEPEVREYLVDICRSTREDDRVDVGISPRGVQRLFEATRARAAIVGRDYVAPEDVHAIVHPVLDHRIVLTTESDVRGVDPTAVVETALNDVSVPSMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXH7</accession>
    <name>A0A3N6MXH7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease V</fullName>
            <ecNumber evidence="2">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Deoxyribonuclease V</fullName>
            <shortName evidence="2">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nfi</name>
        <name evidence="4" type="ORF">EA462_09505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endonuclease V family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90212">
        <property type="protein sequence ID" value="RQG90212"/>
        <property type="gene ID" value="EA462_09505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="28331" checksum="364751B7F90A09B7" modified="2019-02-13" version="1">MRQPRTPRPDLEPDADLEREEMEAMQREIAAAAIFEDDHDVAVGSLSNPLEAASSDRDRPEPPLVAGVDQSFLLESERALSAVVVMQAGEVVERVHAVTPLEIPYIPGLLAFREGGPILAALEGLSTEPDLFLFDGSGRIHFRQAGIATHIGVVLDVPSVGIAKSLLCGEPRGDVDDLPAGTTVPIDANSRVDAPAGTVLGYAVQTRQYDSPDRAINPLYVSPGHRVGPETAADGALELATTYKLPEPIRLADAYADEAKRTLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MZU8</accession>
    <name>A0A3N6MZU8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">nadA</name>
        <name evidence="10" type="ORF">EA462_03810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91132">
        <property type="protein sequence ID" value="RQG91132"/>
        <property type="gene ID" value="EA462_03810"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00569">
        <property type="entry name" value="NadA_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023515">
        <property type="entry name" value="Quinolinate_synth_A_type3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="265"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG91132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="377" mass="42344" checksum="D28F790F6088E90A" modified="2019-02-13" version="1">MVKMETAELETDLSLFKYDNLEQLPTRYRELDEAERTERIEAALGELGDDVVILGHNYQRREIVEHADFIGDSYQLSKQASEADAKYVIFGGVTFMAESADIITADDQTVILPSMEASCPMAGMAEALQVDAAWAEITDAAPEANIVPITYMNSYADLKAFCASQGGLVCTSSNAHRAFEYAFEQGDKVLFLPDKHLGENTAHRLDMEDEIVEWDPWDSDGKDAETVAEQDIILWDGYCQVHERFRPDHIEQIRADHEDANVIVHPECRREVVEAADKAGSTATICETIENAAPGETWAIGTEIHLTKHLQRWHPEVNVLPLCGDACMDCNAMRQIDPNYLTWVLEELIEGRERNVIEVAPEEKDLAKVALDRMLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N001</accession>
    <name>A0A3N6N001_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_04220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91202">
        <property type="protein sequence ID" value="RQG91202"/>
        <property type="gene ID" value="EA462_04220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="6">
        <location>
            <begin position="500"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="772" mass="83991" checksum="FCF87BA44DF15289" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N090</accession>
    <name>A0A3N6N090_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91292">
        <property type="protein sequence ID" value="RQG91292"/>
        <property type="gene ID" value="EA462_04710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="102" mass="10805" checksum="E202B4C41501C738" modified="2019-02-13" version="1">MSERKFTFIELHLDGETQFGPKAINDALPFGEKTAAEELEAKDDDAENGDDATTADDGSAGTVIGAVIALVVLIGLAAAAKKFRGDDEPELEDEDQPEVIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N143</accession>
    <name>A0A3N6N143_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91662">
        <property type="protein sequence ID" value="RQG91662"/>
        <property type="gene ID" value="EA462_06865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="268" mass="27531" checksum="2ED750169F1A6454" modified="2019-02-13" version="1">MSDRDRTGYEESVVIVLVTASVVLGTFGLTVAVAGPDFGGSSATDVLETENESTDGTGSANDATDPMDEHGSLDPENADETDGVTDADDSEGDDGEADDDRSNELEESNETDGETDDDDRNETDDDDRNETDDGSGVVDGEADEEDDSPDDGEDSNDEAGADTDAEGSDESSDDDGDSDEADDDRDGTDDLDGVGSDDEAAEASGDDSEAEDGDSESADEADDDTVPGVDTEPGPDSDDVGIGDGVTDVLEEITSVVEDAVSFGEELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4A2</accession>
    <name>A0A3N6N4A2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_01970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4 6">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93002">
        <property type="protein sequence ID" value="RQG93002"/>
        <property type="gene ID" value="EA462_01970"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG93002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="382" mass="42402" checksum="A013C71E31440D9C" modified="2019-02-13" version="1">MVDDLEKGLEGVLVAESELSSIDGDAGRLIYRGYPIEDLARGASYEEVLYLLWNGHLPNKDELDRFTDALADERDVSDDVLATMERLADAGDRPMAALRTAVSMFSASEPEADADPDDLEATLRKGRRITAKIPTALAAFERYRLGESPIEPRPDLGLAANFLYMLTGEQPDDIAAETFDQALILHADHGLNASTFTSMVIGSTMADIYSAVTGGISALSGPLHGGANQDVMEVLIEIDESDLDHREWVEQATEQGRRIPGFGHRVYNVKDPRAKILQERSEELAANGEDKWYDYTTTIEQYLAEEKGLVEKGIAPNVDFYSGSVYYQLGIPIDMYTPIFAMSRAGGWIAHVLEYQEDNRLIRPRARYTGPEDSEFVPLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4X7</accession>
    <name>A0A3N6N4X7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_03405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93252">
        <property type="protein sequence ID" value="RQG93252"/>
        <property type="gene ID" value="EA462_03405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020935">
        <property type="entry name" value="PdiEstase_YfcE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01269">
        <property type="entry name" value="UPF0025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="170" mass="17986" checksum="7012D3B9FE3CE0F2" modified="2019-02-13" version="1">MITIVSDTHSGRGHELDGEALRAVREADVVIHAGDFTTVPVLESFQEESSRFVAVRGNADNSAVRDRLPTARVVEAGGARFAVTHRRDGGPTGLALFGRSRDADVVVSGHSHRPSVVDAEDCLLLNPGSHADPRGNRPGFAVLEGTADGLAGELRRPNGALLESFDVSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N519</accession>
    <name>A0A3N6N519_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93312">
        <property type="protein sequence ID" value="RQG93312"/>
        <property type="gene ID" value="EA462_02635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="1">
        <location>
            <begin position="280"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="643" mass="68486" checksum="79EC7CDC5DA17564" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVG7</accession>
    <name>A0A3N6NVG7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87822">
        <property type="protein sequence ID" value="RQG87822"/>
        <property type="gene ID" value="EA462_13205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="167" mass="18982" checksum="0A276F1D549A2710" modified="2019-02-13" version="1">MVLSEFTHTSVLATDLEESVAFYEELFGMERVPSPRFSVPVEWLRCGDRTLHLFKREIEAADFYHIGVHVDDFEYVYQQSVERGLESDFDAGGNEPVVYELPDGAVQFYIDDPAGNLVEVNYPDVDELDTSIVSNVIKRSDQLEQTGDATEAKLYFENTTASIEPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWZ3</accession>
    <name>A0A3N6NWZ3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ORF">EA462_12210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89129">
        <property type="protein sequence ID" value="RQG89129"/>
        <property type="gene ID" value="EA462_12210"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_A">
        <property type="entry name" value="PyrH_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011818">
        <property type="entry name" value="Uridylate_kinase_arch/spir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02076">
        <property type="entry name" value="pyrH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="114"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="241" mass="24878" checksum="D2DA67A99FFD9262" modified="2019-02-13" version="1">MKVVVSIGGSVLVPEPGAHRVAEHAAVVENLVSDGCRVGAVVGGGGVAREYIGAARDLGANEIELDQLGIDVTRLNARLLIAALGEESVTAPALDYEEAGDALRQGNVSVMGGVAPAQTTDAVGAALAEYVDADLLVYATSVPGVYSADPNEDESATKYDRLSAAELVDVIAGLEMNAGASAPVDLLAAKIIERSGMRTIVLDGTDSDRIARAVRYGEHDGTDVIPAGVGEEPTYWAEHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYC0</accession>
    <name>A0A3N6NYC0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">2-(3-amino-3-carboxypropyl)histidine synthase</fullName>
            <ecNumber evidence="3 6">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dph2</name>
        <name evidence="7" type="ORF">EA462_07255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DPH1/DPH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 6"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89809">
        <property type="protein sequence ID" value="RQG89809"/>
        <property type="gene ID" value="EA462_07255"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022428">
        <property type="entry name" value="Dph2_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="PTHR10762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03682">
        <property type="entry name" value="arCOG04112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="349" mass="39347" checksum="377E1240EF0A4E48" modified="2019-02-13" version="1">MSQDSAYTDGDLRNTGMRLKHDREWDYELERIVDAIDDRDATTVGLQFPEGLKRRGPSVADDLRKLADDGVTFMLSGQPCYGACDLDTYLMKRTDVFVHFGHSPMKNTDKVIYVPLFSNVDVLPIMEEALETLEDPSETKDVGLVTTAQHMNRYDAMTEFLEERGYEVHSRRGDERLTHEGQVLGCNYASADVPADQVLYVGGGKFHPLGLAMEHPDKHVVIADPVNNVVTPADTDKFMKQRYGAVHRAMDAKKWGVIFCTKIGQGRWEQAQDIIADNDDAYLITMDEVTPDRLRNFDMDAFVNTGCPRITTDDGPQFHKPMLTPGEYEIAVGNEPLENLSFDTFHGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYR0</accession>
    <name>A0A3N6NYR0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89999">
        <property type="protein sequence ID" value="RQG89999"/>
        <property type="gene ID" value="EA462_08305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="13394" checksum="1AA02114452C267C" modified="2019-02-13" version="1">MSDLAAAGVTLENRLMSHGIYVIDFERDERTVSIEYEVVASAPAVTTDEVGAVVRTLLTVADEREWAPGRLEATSRTTDGDVRGHWHVEKEWFDRLSSDLTELEFSNLVLGTITDDPIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ62</accession>
    <name>A0A3N6NZ62_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_16825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86796">
        <property type="protein sequence ID" value="RQG86796"/>
        <property type="gene ID" value="EA462_16825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="574"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG86796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="608" mass="64705" checksum="40CD7DA309801C68" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0B8</accession>
    <name>A0A3N6P0B8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_13525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87878">
        <property type="protein sequence ID" value="RQG87878"/>
        <property type="gene ID" value="EA462_13525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="119"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="221"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG87878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="42233" checksum="AD737761072D8667" modified="2019-02-13" version="1">MYSLTDEQRLIFSECRRIATEEFAPRAFTWDDEPPTENVELLADLELVGLNYPIELGGGGLSEFEVCLQIEAIGRICPDTAQSVYRRSMIAPRVIEMFGSESLKEEYITDVTAGERSISVAISEPQAGSDVQNIGTQLVEDGDGYLLTGEKTWITQGESADSLVVWTRLPDSNMGVVVVDTDQAGVARETDYTNMAGDTQTHFTFSEVSVPESHVVVSGKSGFKRMLRALNWERCASAMGCIAIALCAFDTAVEYAKTREQFGQSISEFQGLRWKFADMAMQIQLGRTMVYNTVITAVENECPPNRLQSSIAALYATEVCNNVVDEALQIHGANGYQQGHPLEYLYRLVRGKRIAAGTDEMLRNTIADAVLDEGLADLPDLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0D5</accession>
    <name>A0A3N6P0D5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87918">
        <property type="protein sequence ID" value="RQG87918"/>
        <property type="gene ID" value="EA462_13730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009936">
        <property type="entry name" value="DUF1468"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07331">
        <property type="entry name" value="TctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="203" mass="22289" checksum="F78686D92DCD8F4A" modified="2019-02-13" version="1">MSTRNTFVKVMERANQTIDSASQWIYNNERKLEIAFVVALLAFFAYAVVTGMDYRRNARLVPTIIAVPTIALLVLVLATLLSSRFAAFAASIASSDMLGIHSKAASSDTQKGESPQSDPFTSERTPASEKRLIMMVLWTGLLLGLVVAIGFSVAILVFAIGFYRIYSGESWYRSVGYAVVLWAFVIVVFQILADIDLYGGIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0M4</accession>
    <name>A0A3N6P0M4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88058">
        <property type="protein sequence ID" value="RQG88058"/>
        <property type="gene ID" value="EA462_14505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="212" mass="24317" checksum="54EA1825820E0413" modified="2019-02-13" version="1">MHEATMSIEYGSLYADLSTEYDVDVELWCNNRWDIIYLRGANAGHAVEALEGELGVYDTVSDETDVLVFTSTCLRRHGDDFIEEYLERHDCRAIPPLSYDTGEIHLRIVASAFADLSNLFEDLSDRFQVSVVSKRELETVGYDLLVPRMTGAKLTDRQRTAIRTAFDRGYYEIPRGSRTADLADELGIDRRTFEYHLRRAENEIVEQFLATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0N9</accession>
    <name>A0A3N6P0N9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HlyC/CorC family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_14665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88088">
        <property type="protein sequence ID" value="RQG88088"/>
        <property type="gene ID" value="EA462_14665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="120"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="188"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG88088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="362" mass="40725" checksum="D82C6A7063E353E9" modified="2019-02-13" version="1" fragment="single">GLLGVILATFGITAIVLLFGESVPKSYAVENTESWAIRISKPLKATEYFLFPLIVLFDYLTRQVNRLTGSTGAIESPYVTRDEIQEMIESGEREGVLEEEEHEMLTRIFRFNNTIVKEVMTPRLDMTAVPKDAAIDEAISICIQSGHARIPVYEGSLDNVQGVVHIRDLVRDLNYGETEAEDLELTDLVQPTLHVPESKNIDELLAEMQEDRTYMHMAIVIDEFGTTEGLVTMEDMIEEIVGEILKSGEEEPVEELDDRTVLVRGEVIIEDVNEALEIDLPEGEEFETIAGFIFNRAGRLVEEGEEITFDGVRITVETVENTRIMKARLHKLEAPEEPEEGAERGNENGEPNDNDIVDRSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0P6</accession>
    <name>A0A3N6P0P6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88098">
        <property type="protein sequence ID" value="RQG88098"/>
        <property type="gene ID" value="EA462_13360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="262"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="388" mass="39860" checksum="BBF84F6C616BABBF" modified="2019-02-13" version="1">MTDVRIVGAGMTSFGDHADRTGRSLFSDVARRALEDASLSSDAVDELFFSSFAGELSESQSHQAPLMASAAGVSAPATRVEAACASGGAAVRQAVTSIRAGVADVVLVGGAEKLTHLSTPDATDALSLAADERWETRIGTTFPGAYALMARAYLERFDADREDLAHVAVKNHANAVDNELAQYRNEIDVEDVLEAPIVSEPLGLYDSCPLTDGAAALVLASDDVVRSRDLSAPVEIAGIGQASDRLSLQERESLCETPATETAARRAYAASGIEPTDVDLAEVHDCFTIAEILAIEGLGFAEIGEGGRAARDGTTTATGTIPVNLSGGLKAKGHPVGATGVAQVVELVKLLTGVHANADAVPDSSVGLAHNAGGTVASAVVSVLEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1F6</accession>
    <name>A0A3N6P1F6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91329">
        <property type="protein sequence ID" value="RQG91329"/>
        <property type="gene ID" value="EA462_04940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GAF" evidence="3">
        <location>
            <begin position="264"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="658" mass="72881" checksum="E87B57DE25FA1B6E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P282</accession>
    <name>A0A3N6P282_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_03515</name>
        <name evidence="7" type="ORF">EA462_06970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91083">
        <property type="protein sequence ID" value="RQG91083"/>
        <property type="gene ID" value="EA462_03515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91679">
        <property type="protein sequence ID" value="RQG91679"/>
        <property type="gene ID" value="EA462_06970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="5">
        <location>
            <begin position="316"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="438" mass="50686" checksum="24F5C4B45192A52B" modified="2019-02-13" version="1">MGIEEVTKTARTRLCIESGERSWLKDARYTARDIANDTLRLKQQGYNKTEIQREVDRDDFLRNNKCAVVGKALQAWDSYKELLNWWYDQDDTNVGKPSPPATDKKGAYPLVMAHSEGYRLTYNDETDRLRFRVSPKPYKKVRGHLRGRQEDLNLIEAALTEEEWSLGQAELLYRDGVYYLHVTVKTEVQVPEPEDADTLVGVDINERNIALTALNRETMDTLGTLVLDYGSVKAERQRYHTITKRCQEHGQHSIHNQLGEKEERYTEWILHRLSRVVVEFAQQFSNPVIVFEDLSGIRDAIKYGTYMNRRLHKLPFHKFEQQVRYKAMWNQIPCETVESPYNSKSCSCCGHRGYRQGRRFRCTNDSCAVQQDHADRNASVNVAWRSWAKHAGVDVESVNYRTRKTQPFVRKVSLSGSGRSVNRPSSSREIASRGVLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3W8</accession>
    <name>A0A3N6P3W8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhamnulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90055">
        <property type="protein sequence ID" value="RQG90055"/>
        <property type="gene ID" value="EA462_08625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="265"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="502" mass="55597" checksum="BCDA5B634327A3B3" modified="2019-02-13" version="1">MRIVILLVFMEPAMSVRVAVDIGSSSGKVYYGTVDEGVEIEEAHRFETNMKTEDGRLVWDIEYLTQEIRAGLEAVVADGESIDSLAIDTTACDFGLLEDGELLANPYCYLDQSLYSKDEELLETVARRDIFSSTGHNGLPSSYYYQYQTHPELFERADTLVALPQLLSYELGAKPTCETSFGVTFRMMDIRTREWATELLSELDLPIDVLPTPVEAGTNVGTVDPSLSESISDDVDILLAPSHDTAAAMAAIPFTPESPGFLCTGSWFIPGLELEEPVINDAAFDVPSSNELSVDGRIRYLRNLPGFSLLEHCRDTWREEGGRHAYDELIEHARDSESFRSIVDTADPLFFEAQSTGNVIEAIRTYCTETEQPIPESEGEVTRCLLESLAIRTAITLEQLMAASETYTDRLHLVGGGVENELFCQMVASATGFRVEAGPVEATAIGNLLSQMNAADEIASYSEGREIIDERIEFAYYEPRRTGEWDRALEHAVAEFGSIDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4A7</accession>
    <name>A0A3N6P4A7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92739">
        <property type="protein sequence ID" value="RQG92739"/>
        <property type="gene ID" value="EA462_00460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="12"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="232" mass="26837" checksum="54A297399867FD94" modified="2019-02-13" version="1">MSDLPDDFDCTITNWEYIYSLCRDVSDEVRRDEFEPDVIVALARGGWFAGRCLCDFLGLDDLTSLKMEHYVGTAEKTGEPTVRYPMPEGSVEGKDVLVIDDIADTGGSIERAFEYVDDRNAGEVRTATLQLLQTSEFEPDYIGERLEEWTWVVYPWNFLEDMIDLITGAMDRADQETFTPDEIRHYLAEYHSVERIEMEIAQPNRVPEVLAEMERRDVIEMHRSGEWALRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4C1</accession>
    <name>A0A3N6P4C1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90225">
        <property type="protein sequence ID" value="RQG90225"/>
        <property type="gene ID" value="EA462_09580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="PTHR43521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="18"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="518" mass="56865" checksum="95201EDF0063A37D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4W8</accession>
    <name>A0A3N6P4W8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribbon-helix-helix protein, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93059">
        <property type="protein sequence ID" value="RQG93059"/>
        <property type="gene ID" value="EA462_02295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="96" mass="10779" checksum="2BB086FCB46AED21" modified="2019-02-13" version="1">MSSGDTQNGDDPEKTNINIRLTETFLEDIDATWAEEGYNSRSEFIREALRDAVRHPGLTRKSWKEIAAVEHARRTGESDAFAPEDSDPSEDPSSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4X8</accession>
    <name>A0A3N6P4X8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="1">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">pdxT</name>
        <name evidence="4" type="ORF">EA462_02360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93069">
        <property type="protein sequence ID" value="RQG93069"/>
        <property type="gene ID" value="EA462_02360"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PTHR31559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="L-glutamine binding" evidence="1 3">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="1 3">
        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1 2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1 2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1 2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 3">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="204" mass="21627" checksum="27A45CBE43F6A943" modified="2019-02-13" version="1">MSLVAGVVAVQGDVEEHANAIERAARARDRDVTVHEIRESGIVPDCDLLAMPGGESTTISRLVHGDGIAPEIRAHVEAGKPLLATCAGLIVASSDAADDRVDELGLLDVTVERNAFGRQKDSFEAPLSVDGLGDEPYPAVFIRAPAIDEVDDASVLASWDDRPVAVRQGSVVGTSFHPELTPDSRIHELTFFDTDDASVPPQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P5C3</accession>
    <name>A0A3N6P5C3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93299">
        <property type="protein sequence ID" value="RQG93299"/>
        <property type="gene ID" value="EA462_01740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="130" mass="14715" checksum="ED8CAE51467DC671" modified="2019-02-13" version="1">MGRESIEDAFADELISACRTAVGDELRSITYFTDETVDQLYLRSDLEQTADLIGFADHERLGFRSQSAYRNTQLGEYGATIRMFENGYLTRIIRGDHGVWVTADSLSMERFEELTSVLRSLLEVDGSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P5Y3</accession>
    <name>A0A3N6P5Y3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91095">
        <property type="protein sequence ID" value="RQG91095"/>
        <property type="gene ID" value="EA462_03595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="1">
        <location>
            <begin position="27"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="289" mass="31087" checksum="4BE72E6E47E4B47D" modified="2019-02-13" version="1">MSDLPSSVHVEPVPGEPAATALVSNERILLIADYHAGYEAGLRYERGVDVPSHASDRRERLLALLQRTNPDRLVVLGDLMHSIGDPGGAERGELEILFESFPAALDVTVVKGNHDGVIETWLGGTGVDEIDDDDRGIETGESSGTDARAFSRTAIVPGSGVAFDGLGVCHGHSWPAPAALESDVLCLGHEHPCVRLEDELGGSRTERAWLRGRIDPTPFRDRPEYEGVSWLETGATPEVVVVPAFNDLVGGTWVNVSGRSFLSPFLPDGLDDGEAYLLDGTRLGSYRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6E2</accession>
    <name>A0A3N6P6E2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91335">
        <property type="protein sequence ID" value="RQG91335"/>
        <property type="gene ID" value="EA462_04980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="89" mass="9891" checksum="255299A5DD5BD17B" modified="2019-02-13" version="1">MKPCHNCQAVIDEYILDKQLEPLRELTVDDFNLCVDCATIVPGACIECNGAVYVPRDVTVTPDFCPACRSDHIERSGYDPGWNLETTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6J1</accession>
    <name>A0A3N6P6J1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">gyrB</name>
        <name evidence="13" type="ORF">EA462_05490</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91425">
        <property type="protein sequence ID" value="RQG91425"/>
        <property type="gene ID" value="EA462_05490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="427"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG91425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="643" mass="71528" checksum="EDD2542C01C63DF0" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6J8</accession>
    <name>A0A3N6P6J8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase small subunit PriS</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">priS</name>
        <name evidence="13" type="ORF">EA462_05615</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="12">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91445">
        <property type="protein sequence ID" value="RQG91445"/>
        <property type="gene ID" value="EA462_05615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00700">
        <property type="entry name" value="DNA_primase_sml_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023639">
        <property type="entry name" value="DNA_primase_ssu_PriS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="PTHR10536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 10 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 10 11" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG91445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="391" mass="44180" checksum="DD7A1E7D0D1E29C4" modified="2019-02-13" version="1">MEERTRAYLRGRFRDHYRRTEITLPPAANEREWGFIPWTDGPGTTMVRHRSLLELGDISEFLVRKRPRHVYFSAGRFRDPGASSMDAKDWQSADLIFDLDADHLPGVTLGEDSYAEMLATCKQALFRLLDFLENDFGFYEMEIVFSGGRGYHVHVRDENVRHLEREHRREIVDYVRGIGLDFEELIETETVAGLGRKTPTERRLLQIEGGWGARTHAHFMEYVDELLELEEETALERLQEFDGIGAGKAQATLNAARNNREGLEAGNVTVHTAVSQLAERFASRAVERDNAPIDEPVTTDTNRLIRLPGSLHGGSGLETVRLERDEIAAFDPLCDAIPATFRGQEIAVDVTDGGEVELGGDIFTVSECDQLLPEYVGVFLMARGRAEKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6L8</accession>
    <name>A0A3N6P6L8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_05850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91485">
        <property type="protein sequence ID" value="RQG91485"/>
        <property type="gene ID" value="EA462_05850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="455" mass="48269" checksum="E8FE0B782E40A7B3" modified="2019-02-13" version="1">MSTVNMPRETWATRIGFILAAVGSAVGLGNIWRFPFQVGQEGGAGFLLMYLLFIVLVGFPAMLVEFVVGRHTERNPVGALKEIGGGAWRYVGWIFVATGFVILSYYSVVAGWTIRYTILGLQDGYLADAGEAEGQFVTFASGLDAIFLHAVFMAAVILIVGLGVKRGIELAVKVMVPAIIAITIGLAIYAATLEGASDAYAYYLAPEWDVIAANWTSILPAAAGQAFFTLSLGMGVMITYASYLDENRNLAEDGAIVIGFDTMIAFVTGLIVFPILFTAGIDPGDPGAGAIFVSLAAAFGDLTLGWLIGAVFFGTVAIAALSSAISLMEVVVSYAIDERNVDRMTAAIGIGGAMFLLGIPSAYDLVLLDLFDLFADQILLVLGGLLLMILVGWSLSTLAIEELERGIGDLGGYGTAWIWAVRIPVVLALFVALTLGVLDYVEFLTGPFSEWLADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6M2</accession>
    <name>A0A3N6P6M2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="8">SHMT</shortName>
            <shortName evidence="8">Serine methylase</shortName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glyA</name>
        <name evidence="11" type="ORF">EA462_05905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91495">
        <property type="protein sequence ID" value="RQG91495"/>
        <property type="gene ID" value="EA462_05905"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="10">
        <location>
            <begin position="7"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="353"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8 9">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG91495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="415" mass="44248" checksum="B0DF2C8B0EDAC185" modified="2019-02-13" version="1">MEHEHVRDVDPAVADALEGEVDRQRSSLQMIASENHASRAVMDAQSSALTNKYAEGYPGSRYYGGCEYADEVEQLAIDRATELFGAEHVNVQPHSGTQANQAVYFAMLEPGDKILSLDLTHGGHLSHGHPANFVGQLYDVEQYEVDAETGYLDYDDLAEQADDFEPDIIVSGYSAYPREIDWERIQEAADAADALHLADIAHITGLVAAGVHSSPVGIADFVTGSTHKTIRAGRGGIVMTSEEYADDIDAAVFPGGQGGPLMHNVAGKAVGFEEALQPAFEEYAEQTVANAKALGEALVDNGFSLVSGGTDNHLVLVDLRESHPDTSGGDAEEALEDAGIVLNGNTVPGETRSAFDPSGIRAGTPALTTRGFDEDDCRTVGNLIARVVDSPDDEDVTADVREDVESLCGQNPLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6N3</accession>
    <name>A0A3N6P6N3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91515">
        <property type="protein sequence ID" value="RQG91515"/>
        <property type="gene ID" value="EA462_06015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="118" mass="13222" checksum="505ABFADCC9C5860" modified="2019-02-13" version="1">MGVLCHENARHGRWRLHRVPPRRLPVRDVLVVDDFSTGSIDNLPDSVRLEVISSDIRSEPIVEECIKRAGEIYHLAAAVGVEKIVDEPLESLETNLRGTNSSSRLPRSTTSRRSSSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHU7</accession>
    <name>A0A3N6LHU7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein transport protein Sec61 gamma subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secE</name>
        <name evidence="10" type="ORF">EA462_17200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86205">
        <property type="protein sequence ID" value="RQG86205"/>
        <property type="gene ID" value="EA462_17200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="SSF103456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG86205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="57" mass="6066" checksum="F034DE1F0C751AE7" modified="2019-02-13" version="1">MDVPYDLTSYVRVLKMATTPTTEEFLQVSKIAGAGILLVGFIGFIIGGIMLLVTGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIG4</accession>
    <name>A0A3N6LIG4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86979">
        <property type="protein sequence ID" value="RQG86979"/>
        <property type="gene ID" value="EA462_15115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="62"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="313" mass="33866" checksum="6DCB31495D15B063" modified="2019-02-13" version="1">MNETREAILEAIADGPVSGPDLATDLDVSRAAIWKHIDELRDAAFEIESGPHGYELLDVSAYNGPSIEYELEAPFSVEYHDAVESTNDLARERAVHGATDVAVVANEQRGSRGRLEREWSSPAGGIWISLVTRPAVAPARAPLYTLAAAVATARIAREAGVDAQIKWPNDVVVPVGDDGDYRKLAGILTEMEGETDRIDWLVVGIGINANLDASDLPDGATSVRDETGDDVDRRRFVQRLVEEFDRARGDLESVVSAWRELALTIGQRVRVERATGELVGDAVDVTETGALVLETDDGRTTVSAGDCEHLRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ35</accession>
    <name>A0A3N6LJ35_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87851">
        <property type="protein sequence ID" value="RQG87851"/>
        <property type="gene ID" value="EA462_13380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="89" mass="10656" checksum="48EC9BAD78B6B0E9" modified="2019-02-13" version="1">MNRGLLNQISDVLATFDLDEAPHYSSLCRWEQQYRMSETGFSKLKEADGEKLRFRSWYNDREKYWEQLSEIVPLQEPAVGRWSRTIPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJU8</accession>
    <name>A0A3N6LJU8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89043">
        <property type="protein sequence ID" value="RQG89043"/>
        <property type="gene ID" value="EA462_11730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="234" mass="24562" checksum="6C7AA2E4DCFCF754" modified="2019-02-13" version="1">MNRAPSRLGLLVVTLVAGASVAVGATFAFRPALAHELFALEALVALVDPATLLLVAVLALALFAPTIGISGKLRASSTDPLVEAADSSAASRVDRDSDARRSPIVGASIDGDVERATDYDGRSHEVRSKARTQVIDSLRPIATRAYATSRGHSTDDAAAAIEDGSWTDDPRAAALLASESGPSTPVWIWLFDLVSGVDPFVRSLEHTIDEIDAIQSTPPERPRTPREESGGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK35</accession>
    <name>A0A3N6LK35_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fructose-bisphosphatase</fullName>
            <ecNumber evidence="2">3.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_16460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86728">
        <property type="protein sequence ID" value="RQG86728"/>
        <property type="gene ID" value="EA462_16460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="29109" checksum="1D54CFA9D4404F6A" modified="2019-02-13" version="1">MDDLPENEYLKTAITAAKSVGDLQNEHCGNIAKSEFKYKSRRDLVTETDIQSEKEIIDIIATKYPNHTIAGEETKGVQGESDKRWVIDPIDGTTNYYHGVPFYAVSIAFKKDGEAEIGVVYCPSTDETYCAINGNGAYYNNKRITVSGETDWERSLIGTGFLSKHIVDEELLGVLQVVVNTTHGIRRFGSAAASLAMVASGQIEGYYHPYLNTWDIAAGVLMVKEAGGTIETFETDEGDSLHVVATNGNIQTELSRLFTSSVTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK74</accession>
    <name>A0A3N6LK74_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86768">
        <property type="protein sequence ID" value="RQG86768"/>
        <property type="gene ID" value="EA462_16675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="2">
        <location>
            <begin position="202"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="350" mass="38096" checksum="608D1ED7BC104A37" modified="2019-02-13" version="1">MTDDRARRLRDLRKRTASDEDEGTKDDESADDSTAPTDGETSDETTGEDSDSDESSQESANGDERGGAELTDGEDESGGEDDRVDFVDETAATDDDREELSYDETDGTAQERPQTGDTPRQGAEEPAPADENEGIDPALQGAIADTSSMVATTETIGGEPTVDASVLSQETDDVGRASTGRGSAMLDQGDSLLHSTHDREDTIQMLELFLNESRYAIEIERISAIVEMKDITRFPRGPDAIDGVTDLRGEITGVLDPTTMLDVEQSELSDDQYIVVLKRSDDKQKLGVRVTDVSQAVTYPKSQIDETGAVMDLDSENQHEFIKGIIKKNVDEETSLITWLDVDAIIENTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKB5</accession>
    <name>A0A3N6LKB5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89048">
        <property type="protein sequence ID" value="RQG89048"/>
        <property type="gene ID" value="EA462_11755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="280" mass="30129" checksum="3BDEEC86FF7DBC19" modified="2019-02-13" version="1">MELLERRRALVEARLVDVIDGLEPETLTEEVRHVALSGGKRVRPMVTILTCETVGGVAEDAVDFGVGIELVHNASLVIDDIIDRSELRRGTGSAWAEFGHGPAIITSDGLLGEAFALFSADPHATRVVSEAMVELGIGEATELSAQPDCEEEYMTLARRKTGALFRAAAELGAIAADSDPVTVEAVGEYAERVGVAFQIRDDVLDAVADADDLGKPTGHDAVLERPSVVQVTDLTPEEANDRARTEADRAIDALERVDVSDPEARGYLLDLAEFVVERER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLM6</accession>
    <name>A0A3N6LLM6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_07040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89768">
        <property type="protein sequence ID" value="RQG89768"/>
        <property type="gene ID" value="EA462_07040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="132"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="354" mass="38760" checksum="BC5A35F90295A766" modified="2019-02-13" version="1">MTTETDSDATTTDGERTEFLSGGERTSRDRTGNPLVNWMENLSEAAYAYLLLLPAFALLALIAFYPLVMTFVMSLREDRTRGLEPLGGFVGLENYADILTGNARLARQFVDVTVSTSYPFVDLGVPFLQQALFVTLAFAIISVVLETTIGFAQAYVLDQDFRGRRWVRVAIILPWAVPIVIQGMIFFLLFQPTVGFGSDLMQWLGVFGPDPLADSQDAFIIILVADVWKSAAFMALLILAGLQSIDRSLYNVARVAGASPWQRFKLITLPLVMPALLVAMLFRTMDAMRVYGLIESTAGCTTVPSLTCLVVEAMFGGTRIYATAAAVAFATAVVIGLIISVYVVFFRDTEGGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLN0</accession>
    <name>A0A3N6LLN0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable urocanate hydratase</fullName>
            <shortName evidence="7">Urocanase</shortName>
            <ecNumber evidence="7">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">hutU</name>
        <name evidence="12" type="ORF">EA462_14520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="7">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88060">
        <property type="protein sequence ID" value="RQG88060"/>
        <property type="gene ID" value="EA462_14520"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="6 7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="10">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="9">
        <location>
            <begin position="152"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="11">
        <location>
            <begin position="364"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="254"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="275"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG88060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="579" mass="63651" checksum="EE55844DF65D6633" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLP6</accession>
    <name>A0A3N6LLP6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88080">
        <property type="protein sequence ID" value="RQG88080"/>
        <property type="gene ID" value="EA462_14625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="54"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="5">
        <location>
            <begin position="309"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="400" mass="45066" checksum="EF22FF59E3E88C09" modified="2019-02-13" version="1">MPDVHDYFAQENEIFRNKDLLQVSHLPDGDRIIGREQELTNLAGAIQPVIDGSTPNNVLVYGKTGTGKSLCSKFITRQAIDRAQENDVIIGVAYVDCLQDSTETQAVQSIAHQLNDTEQTEITIPHSGLSTSEYYRRLWRIIDRRFDAALVILDEVDKIESDDILMQLSRAVESGKLSSSTIGTIGISNKVRYKESLDERIKSSLCEREYVFPPYDATQIQEILRSRSDAFHDGVLEDGVIPRVAALAAREHGDARKAIDILRFAGEIAEETDLETVTESCVDQAHEREETSRLAELISKSPSHAKLVLEAMALLAKQPERADDTVQTTEVYELYKRLCDRDDSSHLKLRRVRDILSELEFLSIIEQERKWAGKGKGNYMENRLVDDPDVIIAACEESSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM47</accession>
    <name>A0A3N6LM47_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_16905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86151">
        <property type="protein sequence ID" value="RQG86151"/>
        <property type="gene ID" value="EA462_16905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG86151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="309" mass="34562" checksum="E2EF749C19FB3E42" modified="2019-02-13" version="1">MTAEDDEPTWDRPDDLEAAREALIGWYEDDHREFPWRRTDDPYAILVSEVMSQQTQLGRVVEAWNAFIERWPTTAALAAADRAEIVGFWTDHSLGYNNRARYLHEAAGQVEAEYGGEFPETPAELEELMGVGPYTANAVASFAFNAGDAVVDTNVKRVCYRAFGVPDDDAAFEAAANELMPEGRSRVWNNAVMELGGVACGQTPRCDEAGCPWREWCGAYASGDFTAPDVPTQPSFDGSRRQFRGRVIAVLREYDELAVDTLGHRIRVDYAPDGENGREWLEELLSDLDDDGLVDVERRDDGTVARLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM82</accession>
    <name>A0A3N6LM82_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Citrate lyase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_17180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86201">
        <property type="protein sequence ID" value="RQG86201"/>
        <property type="gene ID" value="EA462_17180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="3">
        <location>
            <begin position="37"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="350" mass="38120" checksum="13CB46A1EA7BAB16" modified="2019-02-13" version="1">MTDTTRLCRTFQTAPAAVPKEDTAKYLASGLDAKGFEAPDWLVPDLEDGTAPEMKAEGLQNVVERVPGAEFPGEIWPRVEWSYEDSTLRETGRGQIGKLVASLGDEIDGVVVPKIGRLEDVERAAAVVAEAEATNGYDDGSIGLSVIVETGRARSDLREIARFGEQSRLTALIFGPVDYTAELGGRDLGDGRPRWDGLLETLSNEASAAGLLAIGGPFDDLFKTRAGLTYYNADEYADQAEHEARLGLDGSWSLYPKQTIQANTVHMPTPEELERDVGRIERFNEAKRAGTGAVTIDGQMVDEATFKNFRNTVTTVRAIHDTRPAQTGEYYDDDLLERALSLELSYAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMN0</accession>
    <name>A0A3N6LMN0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_11965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89087">
        <property type="protein sequence ID" value="RQG89087"/>
        <property type="gene ID" value="EA462_11965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="259"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="633" mass="68933" checksum="8C9457F092FEC703" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMS7</accession>
    <name>A0A3N6LMS7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89147">
        <property type="protein sequence ID" value="RQG89147"/>
        <property type="gene ID" value="EA462_12305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019964">
        <property type="entry name" value="KH_domain_protein_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039912">
        <property type="entry name" value="PNO1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="PTHR12826:SF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03665">
        <property type="entry name" value="arCOG04150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="82"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="185" mass="20169" checksum="E4C933C19388A2A6" modified="2019-02-13" version="1">MQHVKIPQDRIGVLIGEGGETMREIEAEAEVRLDIDSENGSVAVETVGDPVLGLKGPEVVRAIGRGFPPEDALRLLEGEMMLFDVVDIDAASRNKNDMKRQKGRLIGENGRTRELMEELSGASVVIYGSTLGIIGSPEQVDAARTASEMLLDGAPHGAVYSFLEDRHNEMKHKGMEYHRFPGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMY2</accession>
    <name>A0A3N6LMY2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86915">
        <property type="protein sequence ID" value="RQG86915"/>
        <property type="gene ID" value="EA462_14745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="168" mass="17980" checksum="B96BCBB448AEC85C" modified="2019-02-13" version="1">MNDDTDAPPSVDEFVDYCQIQAGLLSGRVETIATEATDLLDEIDEDVATLRARLEERGGDVAGTATPSSAGGPGDVDVDALEELQDDLEHKQRLAEAKGARMQAFQELAAAYTELAEEVGSADDAAAALEEIVRFEVDNDAPAYFDDRRTLCEAAAEQANAVENDTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP60</accession>
    <name>A0A3N6LP60_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_07635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89877">
        <property type="protein sequence ID" value="RQG89877"/>
        <property type="gene ID" value="EA462_07635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="145"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="423"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="553"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="615"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="831" mass="93550" checksum="9AE908470783E833" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPM7</accession>
    <name>A0A3N6LPM7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90117">
        <property type="protein sequence ID" value="RQG90117"/>
        <property type="gene ID" value="EA462_08975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="284" mass="30538" checksum="50AA619493CC9FB7" modified="2019-02-13" version="1">MAVRRDPLDELVVPDGTQAKEVALETGGDVLVGARSTVEFGVRGRNVLAGENVDFGGEIEADGDCRLDMWCDVAANVLVGQDAYIGERVHIGGELRVAGDLDIGDDVDIEEGFEANGWIVIRNPMPTIVFLFVYLKHLLLLGEEDTAQRLIDELVDDDGEPDAEPLVIPRNATVGDDAWRVSTPATIGSDCRLHGNVRAETIEVDTDCDIFGSLRARGEVTVGEGTRIHGDLTTRDGNVLIEADARVLGDVSCTDLELRPGAEVDGTIRADGEITMGTSERDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPP8</accession>
    <name>A0A3N6LPP8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91463">
        <property type="protein sequence ID" value="RQG91463"/>
        <property type="gene ID" value="EA462_05740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043901">
        <property type="entry name" value="DUF5787"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19100">
        <property type="entry name" value="DUF5787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="347" mass="39535" checksum="984D68E9A8320387" modified="2019-02-13" version="1">MSRYSAEFNFELRTCRWAEREWPPDSDDDRSTLVARQLGTKHRRWDTLVLECDPVGLRERANFGPKRLDGDLLHVVKNAPTEWAYYRDAVPHPGYPWRYVREAIHRADDRGIVDARRAGNRIQIRRKWSYPDWVDRIVAIENKPDLDASAARSLEAQLEYDVAMALSDETWVATEQTGAPVEPVLLEGLPTEVGVIVLDTETLSADVEWYPRSLAVSDPGTRILERPSGGDHDGSAARFDSISADEKAEIRLEIAERAYERGWRSFVDTMRPDCRFFGLRSHAGNQLVPYCDAIDECQTATACSGSCPEFEPEPPAWRMRGWPIDGGPGARCRRLLADRRERRRPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPQ8</accession>
    <name>A0A3N6LPQ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable L-aspartate decarboxylase</fullName>
            <shortName evidence="4">ADC</shortName>
            <ecNumber evidence="4">4.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">mfnA</name>
        <name evidence="6" type="ORF">EA462_05840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family. MfnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91483">
        <property type="protein sequence ID" value="RQG91483"/>
        <property type="gene ID" value="EA462_05840"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01610">
        <property type="entry name" value="MfnA_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020931">
        <property type="entry name" value="MfnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03812">
        <property type="entry name" value="tyr_de_CO2_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4 5">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="361" mass="38595" checksum="9E63BA6A1C97CB53" modified="2019-02-13" version="1">MQMEPQPFDRVLSSMCTEPHPVAREAAERFLATNPGDPGTYRTVSALEDDAIAILGEIAGLEEPAGYVASGGTEANVQAVRIARERADDRRPNVVIPDSGHFSFHKASDVLGVELRVVPTDDRHRADVAAVRAAVDEETALVVGVAGSTEYGRVDPIVVLSEIAADAGAMCHVDAAWGGFVLPFTDYEWHFDHAAIDSMTIDPHKMGQAAVPAGGLLVRSSDLLDELAVDTPYLESTDQATLTGTRSGAGVASAVAAMDELWPDGYRGQYVRSQNNAEWLAGALEQRGYAVVEPTLPLVAADIPQSTFDALRAEGWRLSRAATGEVRIVCMPHVTREMLASFVDDLDRLESRSSAPTAGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPV6</accession>
    <name>A0A3N6LPV6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_11165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88944">
        <property type="protein sequence ID" value="RQG88944"/>
        <property type="gene ID" value="EA462_11165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG88944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="162" mass="17834" checksum="00AC1B7CF0CE6A53" modified="2019-02-13" version="1">MNLNDLRTSVAETLYRQVGRTNGRIQTHRHLPVDVLEDESSYLVVFDAPGTEPDDVQVRYVDGTIRVRFDRFREFREGFDMRFPGRGMTLEGEVDLPADAIVDPDTGMATLSESGTVRIEIPKDSADSSDEGGTATDDLESDASDDDVVPDPAEPGELAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ37</accession>
    <name>A0A3N6LQ37_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91688">
        <property type="protein sequence ID" value="RQG91688"/>
        <property type="gene ID" value="EA462_03885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="268" mass="29243" checksum="83A82FC385B702FA" modified="2019-02-13" version="1">MTLSERDGRDVVIERDEYTCRRCGKHADDDPRGLQLYSVSDRPAETVHDSALVTVCSPCFASLASDPDDACCPDETELFSLVRETTEREGVAVSAVANFASVATELPGELERTTADPVANTRVGSTYVRARRETLLAIDSVDSHLDRLSALESATYGFELSDPLDSFVETGIRLQSQLRGIVSLNERIVAGLEHCHGCFGVLEDGTSRCSACALERRDVDDWCSNSDDAIDFERLFTAINETLQAASGTTETLTDRTTTVAERLHGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ46</accession>
    <name>A0A3N6LQ46_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_11795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89054">
        <property type="protein sequence ID" value="RQG89054"/>
        <property type="gene ID" value="EA462_11795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="594"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="699"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG89054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="765" mass="82597" checksum="EE34D7509A73EE6F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ71</accession>
    <name>A0A3N6LQ71_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AbrB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91713">
        <property type="protein sequence ID" value="RQG91713"/>
        <property type="gene ID" value="EA462_05450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007390">
        <property type="entry name" value="Spore_V_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30029">
        <property type="entry name" value="PTHR30029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04293">
        <property type="entry name" value="SpoVR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="709" mass="81816" checksum="7732346CDB148D8C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRY2</accession>
    <name>A0A3N6LRY2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="6">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiI</name>
        <name evidence="9" type="ORF">EA462_04345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91227">
        <property type="protein sequence ID" value="RQG91227"/>
        <property type="gene ID" value="EA462_04345"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="8">
        <location>
            <begin position="65"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="392" mass="42459" checksum="5B8CCA20F3747A15" modified="2019-02-13" version="1">MHPPGADTVLVRHGDVNTKSNTVKRYMEDILAENLTALLEDRSIPGEVERRWNRPLVHTDEEHVEAATDAATDAFGVVSASSVLTTSTEKDEILATLETAARERYDGGTFAVDARRADKRLPYTSEDLAREGGTAIWEAVEDEFEPAVDLDDPNLTFGVEVREDFAFVYLETVAGPGGLPLGSQEPVIALVSGGIDSPVAAYEIMKRGCPIVPAYVDLGAYGGVDHEARAMETVRTLSGYAPNFDAQVYRIPGGDVVELLVGSMEEGRMLSLRRFFYRAAETLAARVDANGIVTGEAVGQKSSQTVRNLGVTSRATSLPIHRPLLTRDKQEIVAMAREIGTYTDSTIDAGCNRVAPDRAETNARLEPLLEAEPDGLLERAEEAAMNAELVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS50</accession>
    <name>A0A3N6LS50_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_00205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92693">
        <property type="protein sequence ID" value="RQG92693"/>
        <property type="gene ID" value="EA462_00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03477">
        <property type="entry name" value="Rieske_YhfW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038010">
        <property type="entry name" value="YhfW_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="446"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="534" mass="58522" checksum="E57847AD818C68C9" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSJ6</accession>
    <name>A0A3N6LSJ6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 10" type="primary">truA</name>
        <name evidence="10" type="ORF">EA462_01495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92923">
        <property type="protein sequence ID" value="RQG92923"/>
        <property type="gene ID" value="EA462_01495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="9">
        <location>
            <begin position="129"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG92923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="281" mass="30461" checksum="678B4EA4A38CFB7F" modified="2019-02-13" version="1">MSMRAFRIAYDGTEYAGYQRQPDVPTVENAIFDALRSLGVLGSDARKPDGYAAAGRTDAGVSALAQTIGLESPEWLTPRALNGELPGSIRSWASACAPDDFHATHHASRREYTYHLHAPAVDDDRFAAACEALSGPHDVHNLTPDDRNTERSPTLESRRDGDFLVVTVTASGFARELVRRLVSLASAVGSGESPPEKIDRVFAPESLPGHEGIQPAPPEPLVLTDVEYPRLSFEVDPAAAETAREVFDARSVERRARARVARMVADGVQDRGGDSSPRDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSP9</accession>
    <name>A0A3N6LSP9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR00296 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92988">
        <property type="protein sequence ID" value="RQG92988"/>
        <property type="gene ID" value="EA462_01890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="PTHR13016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00296">
        <property type="entry name" value="TIGR00296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="199" mass="21566" checksum="55F4C7B643B59F31" modified="2019-02-13" version="1">MSQRQGVDLSYEDGARAVKLARESVESYVQHGQREQPGSMREAFYERTGAFVRLESTRGRGSLRGCAGGYRSGDQLGHVIVDAAIEAASEDSCGSEVSPSELSNLTVSVCAVKNVVLTDDPLADLELGTHGIAIDGGEGGWLYPTVPVEHGWSEREYLDRTCRKAKLAPSAWQDDDVVVTLFEGQVFRERDAGGSIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSU6</accession>
    <name>A0A3N6LSU6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91637">
        <property type="protein sequence ID" value="RQG91637"/>
        <property type="gene ID" value="EA462_06730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="273" mass="29279" checksum="12DAF649BD2616B2" modified="2019-02-13" version="1">MDVATVDELFARDRRDERTALVDRTGREYDAHWLCTTAWKAGNFLRHAGVREGTTVGVVGDGPLALVSFLGTTLLEGTTRFEPPSDLSSEDGFRALVAPVTVLESGTYDLPPGAQRLGYGEKPTEPAVQHFDAGLWSENPSFPPRSIDPSVAMVSDGDRLVSHETALEAARDVIDEYGLAAGDRVVVREPWPVLETVVAGVIAPLLADGVVVLADGEGVSALEDETKERAFEDGELDGSIEPPARGEYAVSSEPVPEPERIVPDSVSLDDPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSU7</accession>
    <name>A0A3N6LSU7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS630 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_02255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93053">
        <property type="protein sequence ID" value="RQG93053"/>
        <property type="gene ID" value="EA462_02255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="3">
        <location>
            <begin position="245"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="368" mass="42308" checksum="150A125604B6FBDC" modified="2019-02-13" version="1">MTGREKEIVRHLSEDDLDRLLTQTDDEKVSKRLTFIKRLYKGATLEDAADDVGMSQSTGSLWAKRWNEGGLGKLTPNFGDGRPPKLGEDERERLLDLLEDGEPWKKQEIQHLLNEEFDIEFHPNYIPRLLDDLGLSYAIPRTERPDRPENADEILDERVSDAFAEDKKDEPHNKQPEDDGDEEWTVDDDIRTDGGTTIGFFDISHPQPWDNSQRLYTVSEPTITRPLVKIDTPAAGFYALNGESVLQFPLNQEKERICACFEEIREQNPSQRILLVLDNFSSHICAHTRKRAHELGIDLIFLPVGSPHLNPIEPVWKSLKWESSPLIVEGADEYRALLDRIFTNLTNRLSFAGSWIENHLSKFIKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSV3</accession>
    <name>A0A3N6LSV3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91647">
        <property type="protein sequence ID" value="RQG91647"/>
        <property type="gene ID" value="EA462_06780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="219" mass="24866" checksum="3807DC5C802D8E7C" modified="2019-02-13" version="1">MDSAALLDLLGNENRRRILRLLARKPCYVTEISEYLSVSPKAVIEHLRKLEEAGLIESRVDDQRRKYFHIARNVRLEVNVSPYGFASKSAYPANNSFDITTCRHLSLDISWDNTDELDELLGALEDLEQLENELSLAQRWVQSRLCDVLDQVSEEVGGGPESRIYADLLARIRTEPRSVGELGGDLDVPREVVAELLERMADEGIVRRTERGWELTTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT05</accession>
    <name>A0A3N6LT05_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93123">
        <property type="protein sequence ID" value="RQG93123"/>
        <property type="gene ID" value="EA462_02660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="417" mass="43751" checksum="381167CD775C4A62" modified="2019-02-13" version="1">MIEVTTEIIVGVAFGLVVAIGPAIAVGTLGAAGAYLGRGLSRPESVAIALSLAVGNGYAIGVVGPQIIDVRTQTPRLLVATAIVALLAMYANSLGARIASELPIGSSFPLVRNRSLSPESLESVDASGQVTIQSTGDVRDIEGYPPLSPRVRHVLEQGSWRVPADLSLPELERRLEQRLRTTENLAAVSVSIDGTGRATIAAAPPASEVASRVPDGWRAVSVPALVPSGAVPGEEIVVYTRDGAVTGSLLETNDGDRIGRVNDGTIGGEKCVTVAVPIADAESVLRTDRCRLGVRPQRASETVEALALLERADCSIGRVTGGELTAILEDDHERADVWPIVADSSESREVDTERPRQWVVEPAIADLATDDDVFVVAESLTVDRIREGNESTASSASSISDREIESTIPPAEPEGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT32</accession>
    <name>A0A3N6LT32_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2'-5' RNA ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93178">
        <property type="protein sequence ID" value="RQG93178"/>
        <property type="gene ID" value="EA462_02965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="166" mass="18105" checksum="DE633DA7A19894D6" modified="2019-02-13" version="1">MYSVNVPVPGRVRTLANDLYPDLVAFDTVRDDHSCLLKRFGDADHVARLQQRAHRALEGAPAVEARITGIEYFADPPLGSAPVVYLAVESPGLESIHADLATAFEVVDGLEGPDYVPHVTLARGGDEATAQRLAAREIEPITWTVSELEFWDGSYRLPVSRISLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUE9</accession>
    <name>A0A3N6LUE9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enolase</fullName>
            <ecNumber evidence="7">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eno</name>
        <name evidence="12" type="ORF">EA462_04175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell surface</location>
        </subcellularLocation>
        <text evidence="7">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91194">
        <property type="protein sequence ID" value="RQG91194"/>
        <property type="gene ID" value="EA462_04175"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="10">
        <location>
            <begin position="130"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="354"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG91194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="401" mass="41810" checksum="6771F13D84E0E9CD" modified="2019-02-13" version="1">MTLITDVRLRRILDSRGNPTVEADVVTESGGFGRAAAPSGASTGEYEAIERPPTEAIAAAREHAVPRLIGEAYAGNQREVDAILRAADGTDDFSEIGANSAVAISMAAAKAGADVLGAPLFQHLGGAFRGDNFPIPLGNVVGGGEHAADATDIQEFLAAPIGAPSVGDAVFANAAVHAAVSDLLTERDVPCGKGDEGAWAPSIDDGEAFELVDEAVSLVEDEVGFEISFGLDVAGAELYDAGSGTYEYSDTSRTTDEQIEYIADLVREYDLAYVEDPLDENDYEAFADLTDEVGDRTLVCGDDLFVTNTDRLADGIDVGAANSILIKPNQIGTLTDAFDAIELATAHGYDSVVSHRSGETEDATIAHLAVATDVPFIKTGAVGGERTAKLNELIRIADDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWB6</accession>
    <name>A0A3N6LWB6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable queuosine precursor transporter</fullName>
            <shortName evidence="1">Q precursor transporter</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93127">
        <property type="protein sequence ID" value="RQG93127"/>
        <property type="gene ID" value="EA462_02680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02088">
        <property type="entry name" value="Q_prec_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00697">
        <property type="entry name" value="TIGR00697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="238" mass="25178" checksum="94D00D99837BF5DD" modified="2019-02-13" version="1">MDNRHGAPTIPQVALIGLFVASLVTAQLTASKVLAFELPVSLPITGAELMLPGAALAYALTFLASDCYTELYGKRAAQIVVNVAFALNFVVLALVWSTIAAPAAEASVDPDAFSTALGASTNVVLGSLLAYLVSQNWDVWLFHWIRDRTGTEKLWLRNLVSTGTSQAIDTVIFVSIAFAIAPAVLDVGVVLPLEAILALIIGQYLLKLAIAVLDTPVVYAIVAFVRARTDDGGRPTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY94</accession>
    <name>A0A3N6LY94_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86682">
        <property type="protein sequence ID" value="RQG86682"/>
        <property type="gene ID" value="EA462_16195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02850">
        <property type="entry name" value="E_set_Cellulase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004197">
        <property type="entry name" value="Cellulase_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02927">
        <property type="entry name" value="CelD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CelD_N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="597" mass="66677" checksum="CF327CE42ADDC3BF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYM5</accession>
    <name>A0A3N6LYM5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_01800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92974">
        <property type="protein sequence ID" value="RQG92974"/>
        <property type="gene ID" value="EA462_01800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="249" mass="27657" checksum="83A4FAD2EA1B2A5E" modified="2019-02-13" version="1">MDAAVLREDMVDGLESPPREVLTDETVAIAMRDVPRHVFVGDERTAYADREHEILGTRVLAPKTTARLLQALSIEEGESSVLIVGVGVGYTAAIAAELAGSRNVHAVDIARPLVFEARANLHEAGYDEVLVDRRDGADGLPEYAPFDRILLEAAAVEPPRALLEQLSDDGRLVFPRGTHRQRLEAVSPDGGRERFGSVSFDPLLVEGEQPGAVERNRTAREDREHARRHARSRRGWEQEWVQWEETIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ96</accession>
    <name>A0A3N6LZ96_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87092">
        <property type="protein sequence ID" value="RQG87092"/>
        <property type="gene ID" value="EA462_15795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="203" mass="21376" checksum="B84BDA75C86F2CD3" modified="2019-02-13" version="1">MASQFTDDDVGKTVVNADGEEVGIVAGVEHGTAHVEPNPGIADTIKAKLGWGGTAEDAYPLQEESVARVTDDEIRLETDLSGTGSSAGTTGGRSDVDTGATDTAGGTDRRTEMGDDDDLIGDDDDGLMDDDDGLMGDDDDDGLMDDDDGLMDDDDDDLMDDDDDGLMDDDDGLMDDDDDDLMDDDDDGLMDDDDDDLIGDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZS7</accession>
    <name>A0A3N6LZS7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDDEXK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88810">
        <property type="protein sequence ID" value="RQG88810"/>
        <property type="gene ID" value="EA462_10420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="2">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="370" mass="40603" checksum="2873A491EEBB7550" modified="2019-02-13" version="1">MSDDSVDQSRADSRIPADGLDTYLRCPRQYEFAHVYGLERDDDAVDERVDLLRRSICAALESGETDAEALGEVARTRLSSLWEDHDERFHSRAQRRHERNVLEATLEAYVSRVGADHAAGIDVLASTADVDGALVGPDRTLSSRVSASPPAAPSEPSSSADANRESGSRTVSRCEPRSVAIEASVDYVYGEGSSIVGVRFVPTLAPLGPLRYRSEWDGDVAALFEDHFDPDAAAFEPGPVGALLETAVVLEGLRTLRDRLGLEGRTCRFVVIPLADRSGTSVNWVSESVETSLEIVDLTDVYIDHHTYGMTHEHRNETVETRLETVAAQLVSDGFDPSDRWDDIERTVCPDCAYAVCCQERIATEVRFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1D7</accession>
    <name>A0A3N6M1D7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose 1-dehydrogenase</fullName>
            <shortName evidence="6">GDH</shortName>
            <shortName evidence="6">GlcDH</shortName>
            <ecNumber evidence="6">1.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gdh</name>
        <name evidence="10" type="ORF">EA462_10935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14293"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14405"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88901">
        <property type="protein sequence ID" value="RQG88901"/>
        <property type="gene ID" value="EA462_10935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047934">
        <property type="term" value="F:glucose 1-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047935">
        <property type="term" value="F:glucose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019595">
        <property type="term" value="P:non-phosphorylated glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02127">
        <property type="entry name" value="Glucose_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026583">
        <property type="entry name" value="Glc_1-DH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="8">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_dehyd_C" evidence="9">
        <location>
            <begin position="143"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="181"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="271"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="300"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG88901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="356" mass="38606" checksum="B6925EE3AC20A837" modified="2019-02-13" version="1">MNAIAVEPGTGSPVLVERPRPEPESGEALVRTLRVGVDGTDHEVIAGHHGEVPDGEDRLVLGHEAVGVVEDPNDTSLEEGQYVVPTVRRPPAGLDNEYFEHDEPDMAPAGEYVERGIAGAHGFMAEYVTSPEEYLVPVPAELAPLGFLVEPISITEKAIEHAVASRSAFEWEPESALVLGNGSLGLLTLAMFETVLGIDRTYCLGRRDRPDPTIDIIDDLGSTYVDSRETPVSEIQSTHEAVDIVYEATGYPKHAFETVDALAPNGVGVLLGVPEPWTFEIDGGRLHREMVLHNKALIGTVNSHRGHFEAAVDTLAQLPDRVTDDLVTGIYDLENYESAFETNDGVIKTAVEFDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M266</accession>
    <name>A0A3N6M266_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinylglutamate desuccinylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_07720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89890">
        <property type="protein sequence ID" value="RQG89890"/>
        <property type="gene ID" value="EA462_07720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="28537" checksum="EAE2BE72DE97E956" modified="2019-02-13" version="1">MRVAQIGSGTPEIAVVAGIHGDEPCGVRAIERLLDERPTVERPVKLVVANEKALERQVRFVDVDLNRAFPGGPNAGTHEGELAHELVGELEGCLTFSMHSTQSHADPFAIVNSVTETATDLVPQLPVAAMVETSNFAEGRLFSEIETIEVECGLQGSETAAQNADRLTRAFLTAVEALPGDTVRRDLPVYRLTDVIGKNRADTYEVFVDNFTEVEPGDPFAAADGSTQVASDSFYPVLMSPNGYRDVFGYAAEKIDVLTTTPTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2B3</accession>
    <name>A0A3N6M2B3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">30S ribosomal protein S8e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps8e</name>
        <name evidence="8" type="ORF">EA462_10370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89261">
        <property type="protein sequence ID" value="RQG89261"/>
        <property type="gene ID" value="EA462_10370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00029">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020919">
        <property type="entry name" value="Ribosomal_protein_S8e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_S8e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_S8e/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_S8e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="PTHR10394"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="124" mass="13459" checksum="1A697387C61977A1" modified="2019-02-13" version="1">MQDQGRSTRKRTGGRLKNVRNRRKDELGRLPTETQVGEPRFRTVDVRGNGSKTRALATDVASVNKGGEAVSAEIEDVVENDANPNYVRRNIITKGAVIATSEGQARVTSRPGQTGQVNAVSLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M337</accession>
    <name>A0A3N6M337_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90260">
        <property type="protein sequence ID" value="RQG90260"/>
        <property type="gene ID" value="EA462_09780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="357" mass="37571" checksum="2D1B5B34B1DB7110" modified="2019-02-13" version="1">MTSLTDVYEGSTGEMRDPRRLYAGTALVLFGAILAVVAVLMAATDLFSGFVTALSWEMAPQYASVRIAGGLAGLGVPAALVGVFIVLPANRRVKAAAAISASLCLFGVVLFWHAYPYHWNGVGEDLTFQVSVVYLLGLFTAVWCLFTAVVNFKTRNDPGGMLEMNVTRHNQTILEVSDEDRESSQFGGVGFLGGTPDGEVETQTNAPGAGTGDEKATTDSEGRSSGDPEPARSSDPTTADEDGGTILSSGSKTGPDRSNGPTKPRRGLGGVPSSDGGSAASDVSSPLDEAPTGENGAEIVESAASGPNPDEPTDRYCGNCRHFEYVRSTSGMVPYCGYHEQAMDNMDACEEWMPNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3N2</accession>
    <name>A0A3N6M3N2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86727">
        <property type="protein sequence ID" value="RQG86727"/>
        <property type="gene ID" value="EA462_16455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="1">
        <location>
            <begin position="346"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="430" mass="46134" checksum="4ADA456B5D0D0786" modified="2019-02-13" version="1">MSTTSLYKELESLDEPLRLGIIGVGRMGQSISVTSERLRGIEIAAIADIDLERSWDTMHAMGHDEQAVRTVETVDEARNALKANGKIITTDSFILPKLDGLDVIICATGVPHIGAKIALRAITNEKHVVMLTDEADAVVGPYLSMLAKKTGVTYCGAAGDEPGAILELYNFVKSCGFEVVAAGKGKNNSLDRNATPKAVAEEAKEKKLNPEIYTAFVDGTNSMLEMTMVANATGLSVDKRGLHGPEVDDVQDLANVFSSTGEGGILSRNGVVDYALGGNVAPGVFVVVTTEDDTIQDDLEYLKLGTGPNYVFYRSYHIPTIEPLLSAARAELHGDANLVPQEPVVDTISVAKQNLASGDEIDGIGGETVYGLAENANTAAENDLVPISLIRGATLRRDVEQGEPIQYSDVELQDSELLHLRKLQDSYFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3S5</accession>
    <name>A0A3N6M3S5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_16720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86777">
        <property type="protein sequence ID" value="RQG86777"/>
        <property type="gene ID" value="EA462_16720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="175"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="298"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="390" mass="44391" checksum="B65FAD4845BF8507" modified="2019-02-13" version="1">MELRRTVPVALDVDSDDAVLLDDTVDTFLWCTQYVVDHAFKNEYDTTSKTTLDDETYDDIREKTDGFNGGLVQAARNKAAEACKSVVARWKNGKKASKPTFTSPHVVYDKRIATFHDEYVSLATTDGRIEADYVLPDEDRDTPHSEYLFSDEYETTGAELHYRDGDWVLHVHCKMEVESDTSDKVTPENGTVLGVDLGVNNLAVTSTGTFWTGDEFDHWRREYEKRRGSLQQCGTRWAHENIQSVGRKEEGRFKLMLHRISNELVAEARENGCSVIAFEDLTDIRERTGASWGHKWAFDRLYEYVEYKTEEYGIDVEEVDPENTSRRCSHCGFTHPDNRDGEEFECLKCGYENHADYNAAKNIGLRYLRRNQTGGDGGAPLSVRLNSAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3Z3</accession>
    <name>A0A3N6M3Z3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1918 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89941">
        <property type="protein sequence ID" value="RQG89941"/>
        <property type="gene ID" value="EA462_07990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="68" mass="7474" checksum="D946F74F9A5235F0" modified="2019-02-13" version="1">MSFEEDDRVVLNDEHSEFDGETGTITQTMESMFGDVTYTISFEDGQEAGVPEDSLEAAADDDADESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M454</accession>
    <name>A0A3N6M454_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCA-adding enzyme</fullName>
            <ecNumber evidence="9">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cca</name>
        <name evidence="13" type="ORF">EA462_14805</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86927">
        <property type="protein sequence ID" value="RQG86927"/>
        <property type="gene ID" value="EA462_14805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042090">
        <property type="entry name" value="CCA_tRNA_nucleotrans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015329">
        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643">
        <property type="entry name" value="PTHR39643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09249">
        <property type="entry name" value="tRNA_NucTransf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005335">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="SSF55003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03671">
        <property type="entry name" value="cca_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0692">RNA repair</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="11">
        <location>
            <begin position="62"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTransf2" evidence="12">
        <location>
            <begin position="176"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG86927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="471" mass="52711" checksum="E875D72E5D11749B" modified="2019-02-13" version="1">MNGENADDERDLDGADPSGDELDERDAVVAAVRERVDPDEAERERLRGVAGRLTKRAESKATELCPDADVLRAGSSARNTWTSGDRDIDIFVRFPPTLDRETLESYGLAVGHATLPTGHEEYAEHPYVKGDVDGFDIDVVPCFRLESATEIRSAVDRTPFHTAYLVDRLDDELAADVRVTKQFLKGIGVYGSDLRTRGFSGYLTELLVCEYGGFRPLLEAAREWQPPVHLDPEDHGRTSFDDPLVVIDPTDPDRNVAAVCAAVNVARLQHYAREFLENPDLEYFEPDDPAPLSADELRDHVERRGTTPVAVRFEAPNLVEDQLYPQLRKSLEGITNGLDERGFDVFRATTMANESAVVFVELAVSERPLVERHGGPPVHVRTHAKTFYEAYAETADVYGPFLDGDRYVTERNREFTTARDFLESDEIFSVGLGVHVESALESEYDVLIDTDIETLLEEFGSELRAYFEPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M490</accession>
    <name>A0A3N6M490_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90041">
        <property type="protein sequence ID" value="RQG90041"/>
        <property type="gene ID" value="EA462_08555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="82" mass="8966" checksum="B873273CD44500B1" modified="2019-02-13" version="1">MTELTIPPEADQKRAAKLIQEHVDVGDTVEIREAERTGSDSPTITGEVTGIDPGYLELDGQPLTEGSVRYDEIHTVTRLESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4J8</accession>
    <name>A0A3N6M4J8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cation:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_15760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87087">
        <property type="protein sequence ID" value="RQG87087"/>
        <property type="gene ID" value="EA462_15760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="136"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="665" mass="70503" checksum="3F1D85AFF9EDB5E4" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5A6</accession>
    <name>A0A3N6M5A6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87899">
        <property type="protein sequence ID" value="RQG87899"/>
        <property type="gene ID" value="EA462_13635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="27499" checksum="FD9567DDC2B8BA03" modified="2019-02-13" version="1">MVRTTTDGRVRTLTLDRPESKNAFTPDTASETIEALEAALTDDIRAIVITGDGDAFSAGGDVESMNEREETPLESYTRMSETMNTVIETILSAPVPVIAKVNGDAIGAGTNLVAACDFAIASRDARFGEVFVNVGLIPDSGGTVILPRLVGLRTAKELAMTGKIFDAEEAERLDLINRAVDPDDLEAEVDSLLATLGNRPTQTLALTKRGFHENIHKSLDEGLEYEALLQSLAYGTDAHEEGVSAFLEKRDPEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5Z1</accession>
    <name>A0A3N6M5Z1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II toxin-antitoxin system Phd/YefM family antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91450">
        <property type="protein sequence ID" value="RQG91450"/>
        <property type="gene ID" value="EA462_05650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="2">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="90" mass="9947" checksum="71FD84259EE6F1AF" modified="2019-02-13" version="1">MSTDAGDNGDGDMVKLNVKVPKRLLEEIDELAEELEYTNRSEFIREVLRDTTEPILTPGAQEGVSEGYTDVAAGRTMSTDEARERLGIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6C9</accession>
    <name>A0A3N6M6C9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PaaI family thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91620">
        <property type="protein sequence ID" value="RQG91620"/>
        <property type="gene ID" value="EA462_06630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="70"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="161" mass="17146" checksum="709CF2CED0A5E191" modified="2019-02-13" version="1">MSDDRHALAGDLDELAEIIQTSIDDNQEFLSWLGTTVDGVDEGTMTLSIPYDEKLTNTRSNAPNDRRADIHGGVAATLIDTVGGLALRTELEDPLAASIATINLNVNYLRPATGDLVGTATVIRAGSSIGVSEVVVESTTPDGRTREVVTGQGSYRLFRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8B4</accession>
    <name>A0A3N6M8B4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91611">
        <property type="protein sequence ID" value="RQG91611"/>
        <property type="gene ID" value="EA462_06580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="167" mass="18284" checksum="75C9E761A05AF44E" modified="2019-02-13" version="1">MSVQTSRSDSLAESEVFHILGNDRRRAIVQLLARETGQVDVSDIATEIASRESDSSSVPSNLYKSVYVSLQQTHLPQLEEDAVIEYDSDAKTITAGPNFESVLRYINGHDDQYSTILWIHLTVCVIGLLVIALAGPNLPVVSRIDPVLSSVLVLLAVAMSSLYRLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8E9</accession>
    <name>A0A3N6M8E9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_06750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91641">
        <property type="protein sequence ID" value="RQG91641"/>
        <property type="gene ID" value="EA462_06750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="49"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="331" mass="35472" checksum="819746A1AB980555" modified="2019-02-13" version="1">MSFDNSGGVADQSNEPDDDVDTDIDTSDVEDLASRSEYDDERANEIQSSIAELGESTVEISDRLEEIHAEADEQYESVMLVAEEMSNLSASVEEIASSSEEVAAAGESARDLAEAGQESANELGTAMGAIQRTANGVTEDVNAIQESVGEIDEIVEVINNIAKQTNLLALNASIEAAHADKAGDGFAVVASEVKSLAEDSQKRATEIETMIREVESNTENAVESLDENNDRIDRGIESIDRAVDILEEIHDTIEDVSDGIDEVAQATDQQASSTEEVASMVDQTVESAERIAEDTGVIASEVESQTDHIETMDRTLEHLVDDFAPNASPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M979</accession>
    <name>A0A3N6M979_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92830">
        <property type="protein sequence ID" value="RQG92830"/>
        <property type="gene ID" value="EA462_00970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="188" mass="21328" checksum="514E5A3EEA358C0C" modified="2019-02-13" version="1">MSRGSWLHLDDLRESWLFLIIGEAEKPDHHQDSQSSIAEIEYWELGVGNPETLVETTASSLSGEHVHSQTELLSKLLNELRTYRYQGTVLITPDRSTIQRLRAALVSGDVETPSLRGFAHIDIESQLQSQFGQALGDYGLAEEEWRRPRVTDDDQQRVVNTGTVERIWEVWTQVYRLVPGNSLEGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9P3</accession>
    <name>A0A3N6M9P3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF2079 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_02065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93020">
        <property type="protein sequence ID" value="RQG93020"/>
        <property type="gene ID" value="EA462_02065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018650">
        <property type="entry name" value="STSV1_Orf64"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09852">
        <property type="entry name" value="DUF2079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="800"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="808"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG93020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="866" mass="94799" checksum="06F423C1CF83B291" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9Z0</accession>
    <name>A0A3N6M9Z0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93130">
        <property type="protein sequence ID" value="RQG93130"/>
        <property type="gene ID" value="EA462_02695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="147" mass="16206" checksum="829788FA72BEB01B" modified="2019-02-13" version="1">MPQPYRGRPPSVSRFTLSGGRVAVRIPRDGTHFSKLENGYPLSEEFLDHLAKDGVDAIVIDDGERSYVFDLYTYRQGNRIGHEPYPMKRVASLDDATVGLSAGETSLTGSDSDWEWVTDTDLRPPFDQSDASSSSVTHESPDEPGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MAE3</accession>
    <name>A0A3N6MAE3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93310">
        <property type="protein sequence ID" value="RQG93310"/>
        <property type="gene ID" value="EA462_02470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="14099" checksum="B6C2FC669EFE9295" modified="2019-02-13" version="1">MGASDWAGRMVEQLEDEFGTAEKRNLRITALVRWFASDPEYEGLFDGNRQEEQHEWSLLTDDLPSVLREQPGSTIEERWNNLMLELEYQEIVEGGVYLNPWEQFDKETYDPDVTHDWDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBJ7</accession>
    <name>A0A3N6MBJ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_01035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92841">
        <property type="protein sequence ID" value="RQG92841"/>
        <property type="gene ID" value="EA462_01035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="116"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="337" mass="39199" checksum="4EB64956461B64B7" modified="2019-02-13" version="1">MTTELEPLGPETAKQMYLDERQQELADATLQSHDYRLKQFVQWCENEEIDNLNEFSARDIHRFRVKRRNEDELATASMKGQLATLRVFLRFCVSIDAVQAGLDEKIILPTTTADDARDELLSRDRAQKVLDYLERYRYARLEHALLEVLWHTGLRIGAATGIDVEDYRSDDQYLALVHRPDEGTSLKNGSKSERLVALNDRVCLVLDDWLEVNHPGVVDDHDRTPLFATKRSRLSRNRGRTIAYQYTRPCVYENKCPHNRDIDECEARPTEYAHKCPSALSPHPVRRGSITHHLQSDTPERIVSDRMDVGMDVLERHYDQRSAREKLEQRRQYLPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBX0</accession>
    <name>A0A3N6MBX0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_04070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91176">
        <property type="protein sequence ID" value="RQG91176"/>
        <property type="gene ID" value="EA462_04070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="6">
        <location>
            <begin position="495"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="6">
        <location>
            <begin position="637"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="770" mass="81421" checksum="BAC5B70E49CE749A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCB7</accession>
    <name>A0A3N6MCB7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L32e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_05110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91356">
        <property type="protein sequence ID" value="RQG91356"/>
        <property type="gene ID" value="EA462_05110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_L32e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_L32e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="PTHR23413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="SSF52042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="HhH1" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="254" mass="28001" checksum="52D1E8ACA6BB7EE8" modified="2019-02-13" version="1">MADDDPEPDVEADDVDATDDDDQQELEDISGVGASKADALRDAGFESIEDVKEADQDELAEADGIGNALAARIKADVGDLEVTADTDAEIEDDADEDDEVAVEDVETELQPRGLTEKTPELSADEQRLLDRRKAEGKPQFNRQDYHMKKRTPESWRRPRGGLSKQRRGIKGKGPKVQAGYRTPESVRGKHPSGFDEVYVENTDDLEGVDGDTEAVRIASSVGARKRERIEETAEDNGVRVLNPTYEEVEVDTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCF0</accession>
    <name>A0A3N6MCF0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93171">
        <property type="protein sequence ID" value="RQG93171"/>
        <property type="gene ID" value="EA462_02915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="453" mass="49401" checksum="101F6BADD05BBD5D" modified="2019-02-13" version="1">MAALEDPIEINGVEIPNRLYRAPLLECAGNGPDAVETLIDDLEPAAASGVGLICQGATIVRGEGGCAAPGMTRVHDPAFVSRLSRLTDRIHDHGSRIFLQLEHGGLRSMETWHAEYRAENPALGQLAVSEPPWQLRLLDRIGILSYDPHVLSTEEVYELAVDFGRSAAYAIEAGYDGVHLSGANMGIIQQFCSPFYNRRTDEFGGSPEARLEFPALVHDEIRERAGDVPLITKVPAETPAPPRPLVTRKLSLEDGVEMARRLERIGYDAVVPVETSVVWDMSVVRGEYPDRAWANEALREGYDAAFGGPGRRRLVSVGNRLESIVYDTESAWNESFCRRVRERVSIPVLAEGGIRERSTMDRLLGSSGNEGVRTGSSGAPPACEMVGLARPFYAEPRLGARLLEPETDETGVLCGSCNNCTVPQATGAPGICRTPSVLRRRGELERAGAYERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCU1</accession>
    <name>A0A3N6MCU1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycerol-1-phosphate dehydrogenase [NAD(P)+]</fullName>
            <shortName evidence="11">G1P dehydrogenase</shortName>
            <shortName evidence="11">G1PDH</shortName>
            <ecNumber evidence="11">1.1.1.261</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Enantiomeric glycerophosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">sn-glycerol-1-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">egsA</name>
        <name evidence="15" type="ORF">EA462_06375</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:21412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycerol-1-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.261" evidence="11"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91576">
        <property type="protein sequence ID" value="RQG91576"/>
        <property type="gene ID" value="EA462_06375"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106357">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106358">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NADP+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00497_A">
        <property type="entry name" value="G1P_dehydrogenase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023002">
        <property type="entry name" value="G1P_dehydrogenase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RQG91576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="353" mass="37509" checksum="D95E84EDAA13E017" modified="2019-02-13" version="1">MFEKSTWIRLPRNVVVGHGVRSAVVDVVDDLHLQGRPLFVTSPTPRDVVADPVVEDFRDAGIEPVVVTIEAATFEAVETVVESADAEAVDYLVGIGGGKAIDIAKMASDRLGMGFLSVPTAASHDGIVSNRGSVPDGDTRHSVAAEPPLAVVADTEILADAPWELTTAGCADIISNYTAVMDWRLAKRLKDVEYSEYAAALAEMTAEILVDNADMVRPGLEESAWVVTKALMSSGVAMSIADSSRPASGAEHLFSHQLDRLAPGAALHGHQVGVGSIMTAYLHGGERGVWRDIRDALSSIDAPTTADELGIDDETVIESLTTCHAIRDRYTILGDGMNERAAREVARKTGVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCW5</accession>
    <name>A0A3N6MCW5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91606">
        <property type="protein sequence ID" value="RQG91606"/>
        <property type="gene ID" value="EA462_06550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="6661" checksum="8F63F832CA2E8631" modified="2019-02-13" version="1">MLFAEKRREGDLNNAKTITLAFARVLRLLSFKLPCFVFSSTVDSLRSPICAAENAEREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFK3</accession>
    <name>A0A3N6MFK3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltransferase</fullName>
            <ecNumber evidence="1">2.3.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ggt</name>
        <name evidence="1" type="ORF">EA462_00160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92686">
        <property type="protein sequence ID" value="RQG92686"/>
        <property type="gene ID" value="EA462_00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="553" mass="60422" checksum="37CB15D041ED0279" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGT7</accession>
    <name>A0A3N6MGT7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class A beta-lactamase-related serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_03080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93196">
        <property type="protein sequence ID" value="RQG93196"/>
        <property type="gene ID" value="EA462_03080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="572" mass="61619" checksum="220BF2030032CE2A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSA7</accession>
    <name>A0A3N6MSA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87113">
        <property type="protein sequence ID" value="RQG87113"/>
        <property type="gene ID" value="EA462_15930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="171" mass="19455" checksum="1AA580F2076D2DE7" modified="2019-02-13" version="1">MATREANWETPLDTGGEVFALLRNARKAWIYTYIRHHPETTIQAIVETLELPQRTVYEYVDDLEASGFIDQANEGRPAEYTAQEIDLQLVEDDTKRRITAELVEAIARRTRDDDIDTYVDRHGLDGLAVAIEYAHEYVDGSVTHQIMAREQEISPLEAGVILDALRPVVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUJ6</accession>
    <name>A0A3N6MUJ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89072">
        <property type="protein sequence ID" value="RQG89072"/>
        <property type="gene ID" value="EA462_11885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="410" mass="44974" checksum="A64FF784F29BD044" modified="2019-02-13" version="1">MTRGKRTTRLSERRRAVICASSASIVGAIAGCMQPLLEQSEEQEEESTTTEGDADSGQANTDTDSGNGATDHENARLYSVDSSTGEINWTHDTVPNGQETRITAVTSAEGMVFYATTDSGGGDEQDPVVRCLDADTGDELWEHTFDEGFFAGLSLSGDELYVAKWHDVIVLDVDSGDRLTQYGYSPSYAGFVEGDSHLYFLGSDAVAFDPVGGSERWSRELERTPESRPIFEDDVLYYGTETGHVVALDATDGSQSWETRVDGNASRRPTLTEDHVWVLDEQGVVSAIDRTEGDLVYEHDDRIDGHHIESIDTLVYIPESESANQGTVYEETVTGGELELSERWTYPSSDLFVITRDGEFIGGWNGVNRVSTTGEISMEAEFEDEYSPSFDHVEDSLESTSDTIFVGTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MX70</accession>
    <name>A0A3N6MX70_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatininase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90092">
        <property type="protein sequence ID" value="RQG90092"/>
        <property type="gene ID" value="EA462_08825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="258" mass="28847" checksum="815B3754BD465A48" modified="2019-02-13" version="1">MYLPHRSWPDLVDGADESLAVVPLGSTEQHGPHLPEGTDHLIAESLARAATDRTGHLCTPVIPIGVSAHHRQFPGTMWVEPPVFRDYVESFSRNLSYHGIDRIVYVNAHGGNVPHLREVGRRLRDDETAFAIEWMWDESIPDLIEDVFETPGPHGGPKETAMIMHIARDLVREGRLEEARDGGAVFDYDSERVHGATTFYDSIENSSNGVFGDQTDATPEIGERLFEAAADQLVALIEWMDDQPFDDLMPRSRLNSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0C8</accession>
    <name>A0A3N6N0C8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl2</name>
        <name evidence="7" type="ORF">EA462_05040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91342">
        <property type="protein sequence ID" value="RQG91342"/>
        <property type="gene ID" value="EA462_05040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_A">
        <property type="entry name" value="Ribosomal_L2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_L2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="88"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="239" mass="25518" checksum="EBB61EC1E660712F" modified="2019-02-13" version="1">MGRRIFGQRRGRGTPTFRAPSHRYKAKLEHKKEESDVVRGTVVDIEHDPARSAPIAAVEFDDGDQRLILAPEGISVGEELQVGVSAEIKPGNTLPLAEIPEGVPVCNVEANPGDGGRFARASGTNADLITHDRNAAVVQLPSGEVKRLDPQCRATIGVVAGGGRTEKPMVKAGNKYHKMRARGTKWPRVRGVAMNAVDHPFGGGGRQHPGKPKSVSRDAPPGRKVGDISSRRTGRGGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0D6</accession>
    <name>A0A3N6N0D6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl5</name>
        <name evidence="9" type="ORF">EA462_05090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91352">
        <property type="protein sequence ID" value="RQG91352"/>
        <property type="gene ID" value="EA462_05090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_A">
        <property type="entry name" value="Ribosomal_L5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022804">
        <property type="entry name" value="Ribosomal_L5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="11"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="67"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="179" mass="19841" checksum="251ADD95321D39EA" modified="2019-02-13" version="1">MSEADSGELHEMREPRVEKVVVHMGVGQGGRELGKAEDIIEEVTDQQSVRTQAKRTEPDFGIRQGDPIGTKVTLRGQDANEFLETALPLAELSSKQFDDTGNFSFGVEEHTAFPSQEYDPAIGIYGLDVTVNMVRPGYRIAKRDKANRSIPSSHRLTPEDAISFLEANFDVSVEETDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N165</accession>
    <name>A0A3N6N165_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91692">
        <property type="protein sequence ID" value="RQG91692"/>
        <property type="gene ID" value="EA462_04200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="309" mass="33268" checksum="DF514CB0389143AE" modified="2019-02-13" version="1">MSLVLPSELVVDRFLPTVRAMLATRLAERDMTQREIAANLGVTQAAVSKYVSGDGGGDDRFRDDPETVATVDRIADGLASGEFDGYDALSELLSLVRTLEDRGPICDLHEETMPELEGLGCDLCVRGLDPDVRAERDVLGDVRTAARTLASSPQMADYVPNVGTNIGMALSNPRDETDVAAVPGRIYAVGRRIEIPANPEFGASKHVATAVLAAESVDSRTRGAINVATDESILEAARSAGIDPLEFEADYEDRRAHLQERFRDRGRVPRVAYHRGAFGIEPTTYVFGPAASDAAKLIVELLEAAATNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3M7</accession>
    <name>A0A3N6N3M7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nadE</name>
        <name evidence="10" type="ORF">EA462_00420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92732">
        <property type="protein sequence ID" value="RQG92732"/>
        <property type="gene ID" value="EA462_00420"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG92732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="264" mass="28692" checksum="4FCB1540AF20D640" modified="2019-02-13" version="1">MLDLRFSDAELERHREHITGFVRDRVDAAGVDGAVLGLSGGIDSTLTAYLTAEALGSENLHGLVLPATVSGDENMSDAERVARDLEISYDVLEIEPVVDSLLAVYPEAEGDREAVGNARARVRAVLNYLVANHERRLVIGTGNRSEAAVGYFTKYGDGAVDCHPIGNLYKKQVRQLARHVGVPADLATKTPTAELWADQTDEEEMGIGYDTLDSILATHIDGPLSVAATCRALEVDAETVEQVRRMHDRSEHKRTVPPAPEPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N453</accession>
    <name>A0A3N6N453_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92942">
        <property type="protein sequence ID" value="RQG92942"/>
        <property type="gene ID" value="EA462_01610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="208" mass="22506" checksum="4020E07F04FBABDD" modified="2019-02-13" version="1">MHVIGTVGLPGSGKGEAAAVAREEGIPVVTMGDVVRQETTDRGLDPTKDHGTVAQALREENGPTAIAERSLPMIQDRLEEHETVLVDGLRSGVEVDVFEERFGDEFTLISIEAPFDVRADRIDDRGRDASEDDGGEGLSERDARERDFGMDDAMARADVVVENTDSLESFHDRIRSTIRNGSDGLETTTPESVSGSRDQAESGAEGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4F7</accession>
    <name>A0A3N6N4F7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93062">
        <property type="protein sequence ID" value="RQG93062"/>
        <property type="gene ID" value="EA462_02315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="109" mass="12017" checksum="327CE5902614DEAF" modified="2019-02-13" version="1">MGVRPPSSGDDEEPKSVEFGIAAVAARLKHADLSFPATKDDVAAELGHERIPYDVHGNDVPLGDILEEVETSEFKSRQVLLNELHGPFEVYRKENSGGVIQQMRSMLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4I3</accession>
    <name>A0A3N6N4I3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93092">
        <property type="protein sequence ID" value="RQG93092"/>
        <property type="gene ID" value="EA462_02495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="301" mass="33458" checksum="B2E818EC3FDB7CF3" modified="2019-02-13" version="1">MSVPASARYNPTGQNVDVISTVNGGEEASWAIYRGGGLVGMESDNTRPPADVPIDFVDWPFSKDGEQSFEDHLQVVKEEKPMYAVAPDVENGRDVSTVLEYADQLDSHAGVVIVVPKDAHPEDVGDDYRIGIPCQDRFGGVPWSIWEYRNCEQVHLLGGSPVRHADFKHYVNVRSVDTASIVKAAYRGGFWNEGGWHKDTLGFYGSLEASIDGMNRFWNGGVSVFGQERARALPAGTELPEQEREELLTRGEIPDRWLHIKYPIELEAIEDQIDPNENPWPPSDTLGDGDRVPFPGRAAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4M0</accession>
    <name>A0A3N6N4M0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydroneopterin aldolase</fullName>
            <shortName evidence="1">DHNA</shortName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mptD</name>
        <name evidence="3" type="ORF">EA462_02705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal dihydroneopterin aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93132">
        <property type="protein sequence ID" value="RQG93132"/>
        <property type="gene ID" value="EA462_02705"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02130">
        <property type="entry name" value="DHNA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027508">
        <property type="entry name" value="DHN_aldolase_MptD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036839">
        <property type="entry name" value="MptD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007181">
        <property type="entry name" value="MtpD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04038">
        <property type="entry name" value="DHNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143560">
        <property type="entry name" value="SSF143560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHNA" evidence="2">
        <location>
            <begin position="14"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="126" mass="13857" checksum="F41D8D0F35450D8A" modified="2019-02-13" version="1">MADDTRVSDDETPTDAEAACFEAGIKFGSLYHQFAGTPLSLESASSLARAMEESIENQPHCSDVTVEIRTDELDDALAAASAEYTELTGRFLEVEIVVDYEGRTVVTKMAMEDGYPLMRLEAVRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N536</accession>
    <name>A0A3N6N536_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate dehydrogenase (Acetyl-transferring) E1 component subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdhA</name>
        <name evidence="3" type="ORF">EA462_03480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93332">
        <property type="protein sequence ID" value="RQG93332"/>
        <property type="gene ID" value="EA462_03480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="2">
        <location>
            <begin position="40"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="369" mass="41573" checksum="F3BAA2722E2C5546" modified="2019-02-13" version="1">MSTIQRDPRDRVQVLDEAGRVLEDADVPDLSEAKLVEMYEQMRLARRFDERAVSLQRQGRMGTFPPLSGQEGSQIASAHALEEDDWVFPSYREHGVGLVRGLSLERTLLYWMGHEQGSYVPEDVNVFSVAVPIATQIPHAVGAAWASRLRGERNAFLCYFGDGATSEGDFHEGLNFAGVFDTPTVFFCNNNQWAISVPRERQTASATLAQKASAYGFEGVQVDGMDPLAVYKVTRDAVEKARDPGAGELRPTLIEAVQYRFGAHTTADDPSVYRDADEVERWKQKDPIPRLENYLRRRDVLDDGRVDAIEDRIEDRVAEAIETAEASTRPEPDEIFAHVYEGMPKRLRRQLEYVESIRDRHGDDALLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUR4</accession>
    <name>A0A3N6NUR4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor biosynthesis protein MoaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoaB/Mog family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86930">
        <property type="protein sequence ID" value="RQG86930"/>
        <property type="gene ID" value="EA462_14830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232">
        <property type="entry name" value="PTHR43232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006443">
        <property type="entry name" value="MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="25"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="195" mass="20831" checksum="5566AAB69708AB93" modified="2019-02-13" version="1">MVTDRDERRGTDHHGHDIIDPLYVGIVTVSSSRADETSPDDPGGDTIQECFEAEDHEVRERALVRDDYSSIRTAVRGLVARRDIDVVVTTGGTGVTADDVSPEATSSLFERDLPGFGERFRALSWEEIGTRAIASRATAGIAVDTPVFCIPGSTGACQTACEQLIVPEASHLAGLATRHRAGTTDQSLSAYGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NV30</accession>
    <name>A0A3N6NV30_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SHOCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87120">
        <property type="protein sequence ID" value="RQG87120"/>
        <property type="gene ID" value="EA462_14895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="3">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="168" mass="19775" checksum="137F02DCDE22BE96" modified="2019-02-13" version="1">MNDDPATRFRENITEITAMIVTGLWLVGLFTNQWWWLPLLLVGYIVVVPLVALLFGDESDREEWWDWWDDDSEDESWESETDSGEDDESVDASSSTNRVDSNADALETLRDRYAAGELTDAQFEQKLERLLETETLEDADRWRRDAREDRTHRQFRDSNEDSNLEYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVE5</accession>
    <name>A0A3N6NVE5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87782">
        <property type="protein sequence ID" value="RQG87782"/>
        <property type="gene ID" value="EA462_12980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="18"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="267" mass="29273" checksum="ADEB7EB6C67DB305" modified="2019-02-13" version="1">MSNLLKQKIEEREYPVGNWVSIGHPTVVEVNAMLGFDFVLIDTEHTTMSLETVEHLVRAAEARNEETGSVVRVPDGDPTRIKRVLDIGVDGVMIPMVETAEEAERIVESTLYPPDGIRGIAGGRAAKYGLDFQRYVNTANGSILKIAQIETKTGLENVEEIAAVDGIDALFIGPADLSGSLEKLGDYDAIKVHDAIDTVLDAGREHETPVGTLTLDNDRIERRVEQGFDFQIVGKDAAHLSSSSEDAKDRYERAIAERTELAQQSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ02</accession>
    <name>A0A3N6NZ02_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90119">
        <property type="protein sequence ID" value="RQG90119"/>
        <property type="gene ID" value="EA462_09000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="131" mass="14673" checksum="BFE816073398DF70" modified="2019-02-13" version="1">MSRYGPRIAALERRALRERASLDAADLESDEATRFLRDGAGQAIWLYVEGRTGGRMVRFPPAEMRALECAMNAWLECYTRCYGVELDAEFTVREAAELLLETHNIVDVAQLLTGVPSRECQSSRDAVDTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZE6</accession>
    <name>A0A3N6NZE6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90319">
        <property type="protein sequence ID" value="RQG90319"/>
        <property type="gene ID" value="EA462_10110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="168" mass="18820" checksum="CF66FCEB381C669C" modified="2019-02-13" version="1">MAPELTIEPAEADDIDGITELWVRLARGQRAYDSYVRPEANRSTMRETLAAHRATDGLLVARVGPDLAGFASFSIERGSLELDATRGTLSNLYVEPEYRDRGVGSALLHTAEETLAANGVEVLTLEVMATNEDARRFYRQRGYETFRVAMDRSLDDRPENDTHSKEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZP1</accession>
    <name>A0A3N6NZP1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_15460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87036">
        <property type="protein sequence ID" value="RQG87036"/>
        <property type="gene ID" value="EA462_15460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAT" evidence="4">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="157"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="228" mass="25813" checksum="C2FF50E864685537" modified="2019-02-13" version="1">MAVIAHLRIPADSFELGRILELETTGTIELENMVPLGEKAVPFFSVSDAVRESFEQNVENHPSVERIIEVTRHDDERLYSLDWSVGRDVFLQGVVDLQGQLLSATGTVNTWEFEIRFPTHEALSEFQEYCSNAHISLEVGRIYNPVRPGTGMWYGVTEAQRETLMSAVQGGYYSIPRRMSTQDLADDLGISDQAVTERLRRAIETLTENTLIAMEEELAEEFEQPQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZP5</accession>
    <name>A0A3N6NZP5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87046">
        <property type="protein sequence ID" value="RQG87046"/>
        <property type="gene ID" value="EA462_15515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="79" mass="8423" checksum="A2FBB3EF6BE3C9D9" modified="2019-02-13" version="1">MVGVSSIPWASVETSTGRHCGAHVTNQFARVFGDDRDRAHRCGECDTYCRLSRGSAAGLEVPIPDPETSPGRHGDVPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0A2</accession>
    <name>A0A3N6P0A2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase family protein molybdopterin-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87838">
        <property type="protein sequence ID" value="RQG87838"/>
        <property type="gene ID" value="EA462_13300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="48"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="875" mass="97914" checksum="0CC34A17301BE166" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0V1</accession>
    <name>A0A3N6P0V1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91089">
        <property type="protein sequence ID" value="RQG91089"/>
        <property type="gene ID" value="EA462_03560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="226" mass="24511" checksum="5267E9B04FC90E32" modified="2019-02-13" version="1">MTDGIDTVCFDLDDTLCTYTQPGEVALEAAFERVGVDDPWTIDAYHGQYGDYLEESADIEDLRRRCFGDLAVATGYDRETGWTVAQEYATVRDGAGVERLPGVRRVLESLSGEYRLGLITNGAPGMQRAKLESTGLAERFETVVCAGFDTAPKPDPEPFDVALGRLESTPERAAYVGNSLSSDVAGANAAGLRSIWVPHGETVPDRPDPVPDHQLESLAELPSLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P138</accession>
    <name>A0A3N6P138_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Mevalonate kinase</fullName>
            <shortName evidence="11">MK</shortName>
            <shortName evidence="11">MVK</shortName>
            <ecNumber evidence="2 11">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">mvk</name>
        <name evidence="14" type="ORF">EA462_04205</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="2 11"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91199">
        <property type="protein sequence ID" value="RQG91199"/>
        <property type="gene ID" value="EA462_04205"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00217">
        <property type="entry name" value="Mevalonate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022937">
        <property type="entry name" value="Mevalonate_kinase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="236"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RQG91199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="328" mass="34122" checksum="8EC885D7E9D922AC" modified="2019-02-13" version="1">MTLSSAPGKVYLFGEHAVVYGEPAVPCAIERRARVGVERRSDGKLRVHAEDLSLDGFTVEYGASADDRPDVDVQESLLTAATQYVDSAIEQVREVTGKAEIGFDVTIESDIPLGAGLGSSAAVAVAAIDAGTRALGTTLEADELAERAYRTEHEVQEGQASRADTFCSATGGAVRVEGDDCRSIDAPDLPIVIGFDGGAGDTGELVAGVRRVREEYEFAADTIEAIGDVVRNGEDALAADDVEELGRLMNFNHGLLSALGVSSRSLDTMTWAARDAGALGAKLTGAGGGGCIVALDPTPETQTALSFTPGCEDAFRAALADEGVKRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P174</accession>
    <name>A0A3N6P174_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_10395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88805">
        <property type="protein sequence ID" value="RQG88805"/>
        <property type="gene ID" value="EA462_10395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="325"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="557" mass="60694" checksum="9296959E5F7F2406" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1W2</accession>
    <name>A0A3N6P1W2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91539">
        <property type="protein sequence ID" value="RQG91539"/>
        <property type="gene ID" value="EA462_06155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="129" mass="13168" checksum="5719D15841424C92" modified="2019-02-13" version="1">MTTRKRALTMTLTVAMLGSLMFMGFAGTAAASNHDVDQETGDATVTIETAQQNNNAQVGIAESSSSSFSFGSAASDSKYGNTIGASSYSSSNAEVNQVQVGSQSNSANIENVGAESGDNVNFNFGGFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1Z3</accession>
    <name>A0A3N6P1Z3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91579">
        <property type="protein sequence ID" value="RQG91579"/>
        <property type="gene ID" value="EA462_06390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="76" mass="8075" checksum="2E41ED6733D00CE2" modified="2019-02-13" version="1">MVTAFVMIKANTGEADRLRDEIKAIDGVESAHIVAGDVDIIAKADVGTPAEVKDIAATRIQSIDGIEDTQTYIAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3C4</accession>
    <name>A0A3N6P3C4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_07025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89765">
        <property type="protein sequence ID" value="RQG89765"/>
        <property type="gene ID" value="EA462_07025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="325" mass="36025" checksum="DFEDF606F56CBB5A" modified="2019-02-13" version="1">MLEVLQTSESNGDDVNGVLPSTFPEPTELGLALVVLIFGWFLSKLVVRLAGRTIARRIERPSVTRTVLRGVRVSVLIVTLIVVAAILGLSGGEILLQVTVISAVIAVVLAPLVGSLINGLFILADRPYEIGDMIEITDEGHRGFVEDITIRYTKIFTLQNTFIVIPNSEIQQRDVINYSAEDERTRISVEFEITYESDLEAARRHAERAARSVDTVISGGPDIRIGSARYAAAPVCTIREYADDGIALELFFWTKRPYKQTLARSSVHAAVRKRFLENDIEFAYPHRHHVFDETSGVARVSRTPETVDTPESDPSPQSHDDAVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3L4</accession>
    <name>A0A3N6P3L4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="4">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">surE</name>
        <name evidence="6" type="ORF">EA462_07795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="4">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89905">
        <property type="protein sequence ID" value="RQG89905"/>
        <property type="gene ID" value="EA462_07795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="5">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="271" mass="28472" checksum="5FD1D796E0D2AB13" modified="2019-02-13" version="1">MSDTLEILLTNDDGIDSTGISALYEALSDHASVTVVAPANDQSACGRSISHEVEVSEHELGYAVHGTPADCVVAGLSELGPDPDLVVSGCNKGANLGEYVLGRSGTIGAAVEAAFFDLPAIATSMYVPVGEAPLSDVDLTTADYAEATRVTTFLAEHGLGSGVFDHAGYLNVNVPPVRGEPSPIEITRPSKRYEMGAERAGGSIRLTDRVWETMDPEVIPDPEGTDRRAVAEGRISVSPLTIPHSTNHHEILDDLVAAYADTVVGVDHLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3U9</accession>
    <name>A0A3N6P3U9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90025">
        <property type="protein sequence ID" value="RQG90025"/>
        <property type="gene ID" value="EA462_08445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="274" mass="30246" checksum="ACB4433E3D14CDAB" modified="2019-02-13" version="1">MRGITVTLQKGGVGKTTVAINLAERLATRDNDVLLVDVDPQGSATEGVGCGDAYTAERSLRHVLERTDPLDPGALCRPVAGDTRFDLLPSNAELQHVSRRIYGDDSGELLFYRRIVKPLADEYDWVVFDAPPTIGPLSNAALIATRQVVLPLQLSKPSADALIRTVTNQLFSLNDRLSDPIDILSIVPNRVKGDNEEKRVLEAIEDSQFEPYLPSFSRSDRLETSPGPGIRERIAFRRAYRDGVPLSTYDPNADMLERFETLAAIVENRSTESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3V6</accession>
    <name>A0A3N6P3V6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90035">
        <property type="protein sequence ID" value="RQG90035"/>
        <property type="gene ID" value="EA462_08505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="301" mass="30693" checksum="C4EEF2B8A6607CE2" modified="2019-02-13" version="1">MQFDRFSPNSKACASRRKLLERLGAIGTAGAITGLAGCLARGDRETRACNGYTIEPEADLAGADLSGCELRGADFTEADLSDADLSGANLREANFFLADLSGADLSDADIRDADILVSELAAAELSGTDFSGADLPGRDFSNDDLSGVILADGTLSSSDLSDADLSDAELSGVDLSEALLTGTDLSGADLSGTILEDATIENVTLTGTIASGVALPEIDLSGEDLSNTDFSGTDLSGADLSQTTLSGADLSNSDLTTADLTGADLRDATLENANLSGATISDVNFDGATWRDGSECDPSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4B9</accession>
    <name>A0A3N6P4B9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Riboflavin kinase</fullName>
            <shortName evidence="17">RFK</shortName>
            <ecNumber evidence="5 17">2.7.1.161</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">CTP-dependent riboflavin kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 17">CTP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ribK</name>
        <name evidence="19" type="ORF">EA462_00565</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 17">Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>CTP + riboflavin = CDP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.1.161"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the archaeal riboflavin kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.161" evidence="5 17"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92759">
        <property type="protein sequence ID" value="RQG92759"/>
        <property type="gene ID" value="EA462_00565"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01285">
        <property type="entry name" value="Riboflavin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039063">
        <property type="entry name" value="RibK_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023470">
        <property type="entry name" value="Riboflavin_kinase_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706">
        <property type="entry name" value="PTHR40706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 17" id="KW-0288">FMN</keyword>
    <keyword evidence="12 17 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP-dep_RFKase" evidence="18">
        <location>
            <begin position="105"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="213"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RQG92759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="235" mass="26216" checksum="B4BFFDC993AAA288" modified="2019-02-13" version="1">MSVLADSAVGYDELAVLKLLALEGGLEGDVKISCSDLADRLEASNQTASRRLQRLESATLLERDTVSDGQWVEVTDAGERALHAEYEDYRRIFEADAEVDLEGTVTSGMGEGRHYISLSGYKRQFEDRLGYEPFPGTLNVDLREDSVRRRGALTSLEPIPIDGWEDDERTYGPAVCHRATVETVDGDSYEESHIIAPERTHHDDDQLEIIAPVKLRDELGLEDDDHVIVSVGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4E5</accession>
    <name>A0A3N6P4E5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_00850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92809">
        <property type="protein sequence ID" value="RQG92809"/>
        <property type="gene ID" value="EA462_00850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="7">
        <location>
            <begin position="116"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="860" mass="90331" checksum="3DD30C9A6CC628EF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4U2</accession>
    <name>A0A3N6P4U2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93019">
        <property type="protein sequence ID" value="RQG93019"/>
        <property type="gene ID" value="EA462_02060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="467" mass="51949" checksum="B28F8E1E1F60F51C" modified="2019-02-13" version="1">MKVLLLTIDAWRASHASFVDGSDLGLRRTVAAGCELTPHLASFARDGVAFSRAVAHGPATPYAFPSLFTSTLPLDRGGYERITADRTLLTEPLSDAGWTCTGVHSNPWLKAENGYGRGYECYADVGEFSLPLLERGRNLLHDRFETDDRVFRAVQRIYRRVRTPLRFVADAESEVDFAVGALSSAGDHEFVWVHLLTPHAPYEPPPRHQHRVGIDHAVSDSQPLVRRAQRDPESLTSDEKRTVRRLYAASVRHADEQIAALLSSVDDETLAIVTADHGEALFEHGQVGHEPALYDELLRVPLLIRPPGGTRARTNETLVRHADLAPTVLDYAGIEPPDSYEGRSLRPIVDGTDDRRTDDESGIRPAIAEVASRPGAPGRIDRTALQIVVRTADRKAYFDRGETRCFDLESDPRERRPVRDHPDSEWSELLSVLAARVNSIEETLAGEADASYDESTERRLRDLGYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4V6</accession>
    <name>A0A3N6P4V6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ilvB</name>
        <name evidence="13" type="ORF">EA462_02160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93039">
        <property type="protein sequence ID" value="RQG93039"/>
        <property type="gene ID" value="EA462_02160"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="12">
        <location>
            <begin position="45"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="10">
        <location>
            <begin position="233"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="11">
        <location>
            <begin position="426"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG93039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="603" mass="64072" checksum="B6804C3838A9C266" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P672</accession>
    <name>A0A3N6P672_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent cysteine synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91225">
        <property type="protein sequence ID" value="RQG91225"/>
        <property type="gene ID" value="EA462_04335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="10"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="325" mass="34598" checksum="FA30A98BBB8DC03A" modified="2019-02-13" version="1">MKGSILDTIGSPLVQVDSPEGATVAAKVESFNPGGSAKDRPAVQMIRSAERDGEIEPGDWLVEPTSGNTGIGLALVCAARGYDLTIVMPADKSAERRRIMAAYGAELELIDGDMTDARKRADELEADGATQLGQFDNPANPDAHYRTTGEEIVEQVDEREVDAFVAGVGTGGTISGTGRRLREEFPDVEITAVEPARNPILSTGEPGSDEFQGMGPGFVSENLDRDLIDRVETVKLEDAEDECLRLAREEGVLVGQSSGATSLAAQRIAREIADPDLECPEVPGAFDSPQPASPETDGGELEDCPLVVTVFWDSGERYLSTGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA59</accession>
    <name>A0A3N6PA59_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93225">
        <property type="protein sequence ID" value="RQG93225"/>
        <property type="gene ID" value="EA462_03255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="260" mass="28354" checksum="9016C24DD639F777" modified="2019-02-13" version="1">MFEPRNLSSSVSAVRDLHAPDALVFDCARDFETLAPAQAEDLGLVVDGLEPTSYPDEWLPADTPALLARYAGSEFTIGMPGDGSIVWTHQTAPPVVLVKPRIEGSPDPFVDFLLAEAFVELGLEVPEHFLGFFEAEYREFDRAVDLEPAGTYQIAAALYDGWVGLQSRDVFAEWHADHSDLAAAWQDAGSRLEGRVSELPRAVARGDTDFADAAELACAAIKHALELPAPFAALETEAYRDHGSSYAVRWAEKTFDALSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LID1</accession>
    <name>A0A3N6LID1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit NuoK</fullName>
            <ecNumber evidence="6">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoK</name>
        <name evidence="6" type="ORF">EA462_15870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87104">
        <property type="protein sequence ID" value="RQG87104"/>
        <property type="gene ID" value="EA462_15870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="101" mass="11197" checksum="78758BDA3BBD6F69" modified="2019-02-13" version="1">MTVAVEYYVLLSMALFCIGLFGVLTRRNALLFLMSVELMLNAANINLIAFAFYHGNLTGQVFALFTMALAAAEVAVGLGIILVLYRNFRDVDVTVPTTMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIZ9</accession>
    <name>A0A3N6LIZ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-2-hydroxyglutarate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87996">
        <property type="protein sequence ID" value="RQG87996"/>
        <property type="gene ID" value="EA462_14155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="400" mass="44261" checksum="65BBE7680E52E14E" modified="2019-02-13" version="1">MSDYDVAIIGGGCIGCSTATHLAEGSDFDVCVIEKEYQLGSHQSGRNSGVLHPGFNYPPGSLKAKFSTEGTTRMKEYLTEHNLPLETTGVLVVATDETERRRLSELKRRADENGVKAEIIEGERSVREYEPYAKGNAALYCPEAASIDSQQYVYQLAADAKDGGVEFYMGHRVESVRYEGEHVITTSSGELTSRYLVNAAGLYADKIADELGVGEEYQIVPFRGEYYELVPGMEDVCESMIYPTPDPDLPFLGVHYTRRADGKVIVGPNAVLAFGRESYRNTAIDFTELRETLSYSGFWKLLGSREMARVAWNELNKSYRKERFVSAARTLVPTVRENDLTRSYAGIRAQLVDSDGTLVKDPLLSEGVRSLHVLNAVSPGLTSSLPFGERIAQRTIDSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJP9</accession>
    <name>A0A3N6LJP9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_17030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86174">
        <property type="protein sequence ID" value="RQG86174"/>
        <property type="gene ID" value="EA462_17030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="185"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="367" mass="43766" checksum="9496D4E2749812F7" modified="2019-02-13" version="1">MIDLDEYPITTENSESYLNKRQLLDYRSEREECLEWLLTFGKKPVEATGYAPGTVKPRCYRMDRFYRYVWELEDGYTVNLTHEHADSWMNHLARRDVSATHKRNCMKSLMMLYKWLHHERGLGEWEPEFRFSADSSNQPRDYLTMEERREIRDAALEYGSVPSYNNLTSAERDRWKQYLSQRFEKPKSEITPDDWERANGWKFPSLVWTSLDAGLRPIEVERATLSWVDADNSVLRIPKEESSKNTEHWVVGLRDRTAEILRKWCQQRRTYPQYDGTDTLWLTRQRNPYGQSALRDVLHRLCDIAGIDIEHRQMSWYTIRHSVGTYMTREEDLAAAQTQLRHKSPETTMKYDQTPVEDRRDALDRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKA3</accession>
    <name>A0A3N6LKA3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89028">
        <property type="protein sequence ID" value="RQG89028"/>
        <property type="gene ID" value="EA462_11645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="203" mass="22483" checksum="E6AE6D23F1C5901D" modified="2019-02-13" version="1">MRFDGTFELGDVSTEAVWLVLSDPVMIEQALPGCEFLLEVDDDANFDELRERAEATEEKPPTLPEATPEAVGERAFEEGETYAALMELGVGGVKPSFETTVTIAEREFPRMATTGNGSAANSSFEMSAWMELEEIDDGVAVEWEAEADVFGKIAQLGGRVINPVANRIVNQFFEDVASRLDEVEEPDDETERTRLRDRIQDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKG2</accession>
    <name>A0A3N6LKG2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="9">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lysS</name>
        <name evidence="11" type="ORF">EA462_12205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89128">
        <property type="protein sequence ID" value="RQG89128"/>
        <property type="gene ID" value="EA462_12205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042078">
        <property type="entry name" value="Lys-tRNA-ligase_SC_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="PTHR37940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="67"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="334"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG89128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="572" mass="64559" checksum="2DEDD19C53B31EA3" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLH6</accession>
    <name>A0A3N6LLH6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol reductase thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87970">
        <property type="protein sequence ID" value="RQG87970"/>
        <property type="gene ID" value="EA462_14020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="32"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="146" mass="15942" checksum="0D77EC4759F5EF33" modified="2019-02-13" version="1">MADSTTDERDRIREQKKRELRERLENGIDTADTDGMTSAETPAEPIEIDGQSHLEAVVDSHSVVLVDCYADWCGPCQMLEPTIDAVAAETDAAVAKVDVDAHQRLAQQLGARGVPTLILYADGEAVDRRVGAQDRATLESLIDRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLI8</accession>
    <name>A0A3N6LLI8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87990">
        <property type="protein sequence ID" value="RQG87990"/>
        <property type="gene ID" value="EA462_14120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="195"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="512" mass="56652" checksum="2C1996E45FA3BD4B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLT1</accession>
    <name>A0A3N6LLT1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gas vesicle protein K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_07535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89858">
        <property type="protein sequence ID" value="RQG89858"/>
        <property type="gene ID" value="EA462_07535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007805">
        <property type="entry name" value="Gas-vesicle_GvpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40137">
        <property type="entry name" value="PTHR40137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05121">
        <property type="entry name" value="GvpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="114" mass="12426" checksum="5B143CF7325F9F86" modified="2019-02-13" version="1">MNQIDVGDGEDARQGLLTLVVTVVEILIGALEREAVRRMESGTLSEEEIERLGSQLATIEAEIEQLKRDEEIEEGVDDLRGDLDGLVTDAIEQLHGDPTGVYEPGYSVFGGDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLY7</accession>
    <name>A0A3N6LLY7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="11">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="11">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">nnrE</name>
        <name evidence="9" type="synonym">nnrD</name>
        <name evidence="13" type="ORF">EA462_08030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10 11">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 11">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 9 11">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10 11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 11">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="11"/>
    <dbReference type="EC" id="5.1.99.6" evidence="11"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89948">
        <property type="protein sequence ID" value="RQG89948"/>
        <property type="gene ID" value="EA462_08030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9 11" id="KW-0521">NADP</keyword>
    <keyword evidence="9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="54"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG89948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="475" mass="48921" checksum="72722DB99058F2F7" modified="2019-02-13" version="1">MITGERMGAVDENAAALGVPRRQLMESSGNAVARVVREVAEPGSSVAIVSGRGNNGGDGFVAARFLDEFDLRTLLLGRPETIGTEIARENWDALEEAAYETRVVTDSQNLELPTVDVVVDAILGTGIAGDLREPAATAARAITAADATVVSVDVPSGFDADGGDHSDDAVSADHVVTFHDTKPGLEALEATVTVADIGIPAAAERFVGPGDVDLARPAGREGRPYVIGGGPYTGAPALAAQAALRAGAELSFVAAPDSIAGEIQGYSEDLIVQPYESDRLTTARVDDLVETAERYDDVVVLGPGLGTADETLEATRRFLSSYTGPAVVDADALAVVTEVETEATLVCTPNRRELERMGGPATDSIGEAVDEIESFAADLGHVVLAKGADDVVTDGERTRINRSGTTGMSVGGTGDLLAGIVAALLDHADPLEAAAAGARVNGIAGERLAETKHEGFLASDMLAEIPAALWGDADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM55</accession>
    <name>A0A3N6LM55_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86161">
        <property type="protein sequence ID" value="RQG86161"/>
        <property type="gene ID" value="EA462_16960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="99" mass="10749" checksum="234ECE7F84C08242" modified="2019-02-13" version="1">MTEMTSRSPSAQTGAQYSVQYDRLDDEPLSVAVADAVATVCNVDITDLDPLHYSINADALERLFEPRSDGLRSNGSVAFEYNDCMVTVTASGDIQVDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMA2</accession>
    <name>A0A3N6LMA2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiamine thiazole synthase</fullName>
            <ecNumber evidence="4">2.4.2.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thi4</name>
        <name evidence="5" type="ORF">EA462_09450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:55704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the THI4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.59" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90203">
        <property type="protein sequence ID" value="RQG90203"/>
        <property type="gene ID" value="EA462_09450"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00304">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022828">
        <property type="entry name" value="Thi4_prok"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00292">
        <property type="entry name" value="TIGR00292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="62"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>glycine</name>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="309" mass="32944" checksum="514BE40AD6BBF2F2" modified="2019-02-13" version="1">MSDFDKFSDVGEADVTRAIGQEWTEEFMDFSDSDVIIVGGGPSGLTAAKELAERDVKVMVVEKNNYLGGGFWLGGFLMNKVTVRDPAQQVLDELDVSYKRSQDSEGLFVANGPEACSGLIKAACDAGAKMQNMTEFTDIVIREDHKVSGIVMNWTPVHALPREITCVDPIAVEANLVIDATGHDAMAITKLDERGVLDAPGVQDARERGQVMDQTDGDTYGAPGHDSPGHDSMWVGKSEDAVVEHTGLVHDGLIATGMATATTYGLPRMGPTFGAMLVSGKRAAQVALDELEVDADPVELTSRAAPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMD1</accession>
    <name>A0A3N6LMD1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_16160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86675">
        <property type="protein sequence ID" value="RQG86675"/>
        <property type="gene ID" value="EA462_16160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="159"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="609" mass="66875" checksum="C176890113BF04DD" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LME4</accession>
    <name>A0A3N6LME4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L44e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl44e</name>
        <name evidence="4" type="ORF">EA462_11295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88967">
        <property type="protein sequence ID" value="RQG88967"/>
        <property type="gene ID" value="EA462_11295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01476">
        <property type="entry name" value="Ribosomal_L44e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_L44e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="93" mass="10880" checksum="438B628BBD46E232" modified="2019-02-13" version="1">MQMPRRFNTYCPHCHEHHEHEVEKVRTGRSSGMKWDARRTRRNTAVIGNAGRFSKVPGGNKPTKKTDLKYRCGECGKAHLREGWRTGRLEFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMI5</accession>
    <name>A0A3N6LMI5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="4">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_10130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90323">
        <property type="protein sequence ID" value="RQG90323"/>
        <property type="gene ID" value="EA462_10130"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="11">
        <location>
            <begin position="8"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="10">
        <location>
            <begin position="191"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="10">
        <location>
            <begin position="305"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG90323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="657" mass="71004" checksum="E30A848D68E74641" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNE4</accession>
    <name>A0A3N6LNE4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trm1</name>
        <name evidence="9" type="ORF">EA462_15145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87125">
        <property type="protein sequence ID" value="RQG87125"/>
        <property type="gene ID" value="EA462_15145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004809">
        <property type="term" value="F:tRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00290">
        <property type="entry name" value="tRNA_dimethyltr_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022923">
        <property type="entry name" value="TRM1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="PTHR10631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG87125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="371" mass="40656" checksum="92652DBAD265A5F2" modified="2019-02-13" version="1">MRVTEGGVELAVPGEQTEGVEESVFYNPRQELNRDLTIATLRAYREREDRAETYLDAMTASGVRGVRAGADGWNVTCCDVEEDAIDLARANLERNDVDAAIEHRNVNALMHDSTFDVIDLDPYGTPMPFADAAFGNCRDLVCVTATDTAPLCGAHFNSGVRSYSAVPRNTDYHAEMGVRILLSALARSGARFDVGVDPILTHATSHYVRTYLELEHKPTAADAALEELGYISHCEDCTYRETAFGLIADPLEGCPHCDGNRMLTAGPVWLGSVRDREFVAAVRERVPDAFGTAENARNLCETLEAELDEPTHYDQHKLCRNWGLPANAMDDFLADLREAGYSASRAHYGGTTFKTDANVGQIRDATEDGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNZ1</accession>
    <name>A0A3N6LNZ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_03790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91128">
        <property type="protein sequence ID" value="RQG91128"/>
        <property type="gene ID" value="EA462_03790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="313"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="407" mass="44022" checksum="4F9A1CDCB105CC48" modified="2019-02-13" version="1">MNLRESLRISWRSIRSHKLRSTLTTLGVIIGVAAVITFMVLGSGFSQSIVGDIEADQEPVMTVHTQTEPEDGFGIMPVDTPIYTETDIEELEEVDGIEFVAPDGSLDLVQTSADDEQVTGVIDAHATTADRFEHGSLVDGETFSGDDEVVINEQTSQLFEENLSTDDELTLTFEDGESTTVTVSGVVEAELGDQMPPQLFLPVDPYYTTTVETPDGDEERAYPSLEMRAESIDDVDDAQNSVIDYLESDSHAAELKQSDDEIQVQTVEDAIDQFMDLVDQLTVFIGAVAGIALVVGSIGIANIMIVSVTERTREIGIMKAVGATKRDVMQLFLVESVILGMIGALVGVGLGLAIGYLGVNFLEWPMAYPIDWIGIAIAMGVGVGVVSGLYPAWRAARVDPIEALRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP03</accession>
    <name>A0A3N6LP03_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EthD family reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87947">
        <property type="protein sequence ID" value="RQG87947"/>
        <property type="gene ID" value="EA462_13880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02118">
        <property type="entry name" value="TIGR02118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="1">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="107" mass="12173" checksum="F3949B990C0CAB10" modified="2019-02-13" version="1">MYKAVFMLSRAADLTQEEFVEYWETKHAPIATEIPNLERYAICPATDPEKSPHDGMAELAFESEDDLYAALDSDEFGRVQRDAGEFSDPDSVEFMIVDERAQTETDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP09</accession>
    <name>A0A3N6LP09_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="9">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EA462_03870</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91143">
        <property type="protein sequence ID" value="RQG91143"/>
        <property type="gene ID" value="EA462_03870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061712">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="119"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="353"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG91143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="417" mass="46058" checksum="59C5F7B3D47833A2" modified="2019-02-13" version="1">MARYHIETYGCTSNRGESREIERRLRDAGHYRVDGPDEADVAILNSCTVVEKTERNMLRRAEELATETADLFITGCMALAQGEEFARADIDGRVLHWDEVPEAVTNGECPTTTPDADPVLDGVVGILPIARGCMSDCSYCITKQATGKIDSPPIEENVEKARALIHAGAKEIRITGQDTGVYGWDTGERVLHELLERICAIGGEFRVRVGMANPKGVHGIRGELATVFAENDELYDFLHAPVQSGSDDVLGDMRRQHQVAEYVEVVETFDDILGYWTLSTDFIVGFPTETDRDHAQSMALLRETRPEKVNVTRFSKRPGTDAADMKGLGGTLKKERSKEMSAAKRDIVGDAYAEMVGEVREDVLVVEDGTADSVKCRDSAYRQLIVRNASEYGLEPGDFVDLEVTAHETMYAFGEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPE6</accession>
    <name>A0A3N6LPE6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="2">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="2">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">msrA</name>
        <name evidence="4" type="ORF">EA462_04970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91333">
        <property type="protein sequence ID" value="RQG91333"/>
        <property type="gene ID" value="EA462_04970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="3">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="177" mass="20038" checksum="3B88C2CEEB78B341" modified="2019-02-13" version="1">MERATFGGGCFWCVEAAFEELEGVESATSGYAGGYTEDPTYRAVCSGETGHAEVVQLEYDPDRIEYADLLEVFMTIHDPTTPNRQGPDVGSQYRSAIYTHDEGQLETATAFVDELERTGVYDGIVTEIEPLEEFYEAEEYHQNYFEKNPTDAYCRMHAAPKVEKVRETFDERVSTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPF7</accession>
    <name>A0A3N6LPF7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S19P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps19p</name>
        <name evidence="7" type="ORF">EA462_05045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91343">
        <property type="protein sequence ID" value="RQG91343"/>
        <property type="gene ID" value="EA462_05045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_S19A/S15e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="16204" checksum="7F7DA6C5FF7664A5" modified="2019-02-13" version="1">MSQEYRTGREGDEFTYRGHTLEELQDLELEDVAELLPARKRRSIERGLSVEKQKLLEKGREKGEEETANAPIRTHLRDMPILPEFVGLTFEVYNGQSFERVRVEPEMIGHYLGEFQLTRTSVEHGQAGIGATRSSKFVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPK4</accession>
    <name>A0A3N6LPK4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90087">
        <property type="protein sequence ID" value="RQG90087"/>
        <property type="gene ID" value="EA462_08795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="242" mass="25355" checksum="ACECBC45693B8A0F" modified="2019-02-13" version="1">MSAVNAFDVDFDGSVAIVTGASGALGSAALDRFRSAGATVCAVDVVAPDDDESLLEDDLGPDTEFYEADLTDEGDVESVVSEIVDDHGRIDHLLNIAGTWRGGDPIAETDLEEFEMLVDVNLTTAFLASKHALSHLQESAGSIVSVSARSSLEGGEGDGPYRITKAGIRLLTETIAAENRGTVRANCVMPSVIDTPMNREMMPDSDHDEWVDPGEIADVMAFLCSDGASVTSGAAVPVYGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPR5</accession>
    <name>A0A3N6LPR5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91508">
        <property type="protein sequence ID" value="RQG91508"/>
        <property type="gene ID" value="EA462_05980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="257" mass="28813" checksum="17CFDCDBB2639B44" modified="2019-02-13" version="1">MHAVVLAAGKGTRLRPLTEDKPKALVEVDDRPIIEDVFDNLLEIGISELIVVVGHLKEQIIDRYGDAYEGVPITYAHQREQLGLAHAIRQVEPHVDDDFVLMLGDNVFRANLADVVNRQREARADAAFLVEQVPYDEASRYGVLDTNEYGEIVEVVEKPAEPPSNLVMTGFYTFTPAIFHACHLVQQSDRGEYELPDAIDLLIQSGRTIDAIRMEGWRVDVGYPDDRDRAETQLRQETGPLVESSTESEQPTESTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ20</accession>
    <name>A0A3N6LQ20_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-binding protein MutS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mutS2</name>
        <name evidence="5" type="ORF">EA462_11560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has ATPase and non-specific DNA-binding activities.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89014">
        <property type="protein sequence ID" value="RQG89014"/>
        <property type="gene ID" value="EA462_11560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00971">
        <property type="entry name" value="MutS2_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012401">
        <property type="entry name" value="DNA-bd_MutS2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029254">
        <property type="entry name" value="MutS_C_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="4">
        <location>
            <begin position="492"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="499"/>
            <end position="506"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="689" mass="74328" checksum="6A753B1E93113F3A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRY1</accession>
    <name>A0A3N6LRY1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89964">
        <property type="protein sequence ID" value="RQG89964"/>
        <property type="gene ID" value="EA462_08120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043816">
        <property type="entry name" value="DUF5798"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19111">
        <property type="entry name" value="DUF5798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="112" mass="12248" checksum="ACC545252B05BEC0" modified="2019-02-13" version="1">MGLGSTAKKIQGLSDRAEAMYKQVQQLQQRIIGLEEEMDDTHDTVKRLDHQLGEQRALLLAIADKQGIDGEEILAEAAIDEAELEDDSQADDSATEQPIENAETHSSESAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRY6</accession>
    <name>A0A3N6LRY6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uracil-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89974">
        <property type="protein sequence ID" value="RQG89974"/>
        <property type="gene ID" value="EA462_08180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="2">
        <location>
            <begin position="39"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="219" mass="24672" checksum="D3D797580A239F90" modified="2019-02-13" version="1">MGSRSVSLSVRNVTDRTSNPFGLRPPFDRTEPTERTAVFGYGDANADFHVIGDYPGNHGGTRTGVPFTETDAGSAIQDVLRELEFVHGFRERPDLENLYLSYVHMCCLPDGHEPTESEYAELERFFDAELRAINAHVLLPVGERPTDHVLREYTTQRDRLEFDMPTLHANEVRGRGFMVVPIRDPSEWTDGDREALVSKLESILESDYRQTKGVATSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS69</accession>
    <name>A0A3N6LS69_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_08835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90094">
        <property type="protein sequence ID" value="RQG90094"/>
        <property type="gene ID" value="EA462_08835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="14"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="257" mass="27372" checksum="D6FA0A0448C7F891" modified="2019-02-13" version="1">MSRVGRVRSEATAGWRSFVRRRTAVFFTFFFPVILIVIFGALIRTDPTGGGLFAEPAAYYVPGYLAVVVLFTPLSRMGSEVARHREGNRFEKLATTPLTRLEWLFAQTLVNAVIIGLASLLILALVIALTGAEIVFSPLLVPYVLLGVVCFCGVGAMLGSYTDSRDGAVAASNAIGLPLLFLSETFIALEQLPDWFEPLVGLSPLTYFARGVRAATDPDAAAPNGVGIDPVLANLVVLAVLAGVAFALGARSIPRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS76</accession>
    <name>A0A3N6LS76_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">thiC</name>
        <name evidence="12" type="ORF">EA462_00455</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="10"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92738">
        <property type="protein sequence ID" value="RQG92738"/>
        <property type="gene ID" value="EA462_00455"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="222"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="428"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG92738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="480" mass="52544" checksum="18D06FBBC3E5041E" modified="2019-02-13" version="1">MANTQIAAARSGEITTEIERVAERENRDPEFVREQVAEGQAVIPANRNHDALDPMIIGREFSTKVNANIGNSETTSDLETELEKLHTAVHYGADTVMDLGTGSDLDEIREAHVEHSPIPIGTVPLYEAVKRAESPEEITTELLLAVIEKQAEQGVDYMTIHAGILAEHLPLTDGRKTGIVSRGGSIMAQWMEERGEQNPLFRVYDDICEIFAEHDVTFSLGDSLRPGSLADACDEAQYAELDTLGELTRIAWDHDVQVMVEGPGHVPMHRVAENIARQQDVCDGAPFYVLGPLVTDIAPGYDHITSAIGAAMAAQAGAAMLCYVTPKEHLGLPEEEDVRDGLAAYRIAAHSGDVANGLPGARDWDDALSEARYDFDWREQFRLALDPDRARDYHDQTLPGDNYKEARFCSMCGVDFCSMRIDQDARDVEDGEMSELETTTDLESSPAAEVNLPPVGTHDSSVPSKDETGEDALVERAGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSP5</accession>
    <name>A0A3N6LSP5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2110 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90334">
        <property type="protein sequence ID" value="RQG90334"/>
        <property type="gene ID" value="EA462_10190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016757">
        <property type="entry name" value="UCP019322"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09883">
        <property type="entry name" value="DUF2110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019322">
        <property type="entry name" value="UCP019322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="230" mass="25122" checksum="E0481CC26BE64A15" modified="2019-02-13" version="1">MVVLATKLYVDGDARERSLDSLRSLVTNEIGDLEVEFDLGVRHDEFPSVTIEGADATVARNVLREEFGEIVSDLESGETYVGTLESWDDDGFVLDAGQAVRIPTDELGLGPGSAEQIRERFGLVQHVPLAFVYGGDEPNEGTATPSRLTDAERDRLYEWTRGNGRLNVNCATRAEVRATLNRAGHAQDYVTVERLGLLEQSVVCTEDTDPPGLLASVGEYLPAELRCVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSV2</accession>
    <name>A0A3N6LSV2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Preprotein translocase subunit SecG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Protein transport protein Sec61 subunit beta homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">secG</name>
        <name evidence="14" type="ORF">EA462_02355</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93068">
        <property type="protein sequence ID" value="RQG93068"/>
        <property type="gene ID" value="EA462_02355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00751">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023531">
        <property type="entry name" value="Preprot_translocase_SecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RQG93068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="53" mass="5573" checksum="033D516A49BD607C" modified="2019-02-13" version="1">MDKGQNTGGLMSSAGLVRYFDTEDSNAILINPKTVIATGVMIGVLVQLLSFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT19</accession>
    <name>A0A3N6LT19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93158">
        <property type="protein sequence ID" value="RQG93158"/>
        <property type="gene ID" value="EA462_02850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="270" mass="30621" checksum="4A86FB4BEE47B392" modified="2019-02-13" version="1">MTDREGDRDHRFSEGEGFDDAYDEFDLDPPELAVDPSKVDPVDSRVVTDTLDDQQIASDDVDAAELLDVGLNYMGINRYEQATDAFGRAAQFAEDDLLAQESWVNKGVAHAELEEWDEAIGAHREALSIDDRSEHAATAETNLAYALWEFGETATALEHAERAVEIDERFAEGWFNRAFFLSERGLSEEALNCVDNAIRLGMRNARVLEEKAQILEDLGEYDEAEEIAEEANEMRERVEQQMMEDRMEGRGQMPDGSDPSRADDRERRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LTA9</accession>
    <name>A0A3N6LTA9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93263">
        <property type="protein sequence ID" value="RQG93263"/>
        <property type="gene ID" value="EA462_03465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="199" mass="20020" checksum="5929E3B4AD852645" modified="2019-02-13" version="1">MSQQPLAATERSVSRASSVAASAGVGVLAAVIGYLVTYVAVAGEVEEAVGDSVAEWKGVAWYYYNAHLVDIDASGEIGSIGGSRTVDFIAQSGSTSATLLYVVPPLVLLGVGAMVAYQFDARDLGEAVIAGAPVTIGYAVVMGLGAVVTEASTEGSFFGVDLSGSIAPQLVPAIFLGGVLYPLVFATAGAILATVLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUK8</accession>
    <name>A0A3N6LUK8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91244">
        <property type="protein sequence ID" value="RQG91244"/>
        <property type="gene ID" value="EA462_04435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="363" mass="39540" checksum="7152C13F6F5D1698" modified="2019-02-13" version="1">MYKGKTIGVVVTAYDESAFVGRVIETVPDFVDRIYVVDDASPDDSWAVIQRVASRMNDRVEPSRAVADGGDSADGEAGRRVMTIRHEENRGYGGAVKTGYERASEDGIDVVAVMNGDGQMDPAILDRIIDPVATGEADYAKGNRLLHPDDREGMSSFRLLGNAMLTGLSKFASGYWTIGDPQNGYTAISGETIEELDLESITDQYGFLNHILTHLNLNGCRVADVSMSAVYGDEESSIRYVPFVRYVSLLLLQSFLWRLKRRYVLEGFHPTVLFYATGATGLAGGAFCLLGALGRSLRGKEGFSGGIAAFVAVLLGLVSLGIAISMDADESEELEVTYYEYSGEETEIDRPADRPIEAHQQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVE2</accession>
    <name>A0A3N6LVE2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin-like protein CetZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cetZ</name>
        <name evidence="8" type="ORF">EA462_06815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in cell shape control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CetZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91654">
        <property type="protein sequence ID" value="RQG91654"/>
        <property type="gene ID" value="EA462_06815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01946">
        <property type="entry name" value="CetZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032907">
        <property type="entry name" value="CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="2"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="10"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="392" mass="41895" checksum="1AB6B872ADCA38C2" modified="2019-02-13" version="1">MKLAMIGFGQAGGKIVDRFLDYDDRTDSGIVRAAIAVNSAKADLMGLERIPQDNRVLIGQARVKGHGVGADNELGAEIAEEDIDEVQNAIDSIPTHEVDAFLIVAGMGGGTGSGGAPVLAKHLKRIYTIPVYGLGVLPGTDEGGIYTLNAARSFQTFVREVDNLLVFDNDSWRQTGESVEGGYDQINEEIVRRFGILFGAGEVTGGQDVAESVVDSSEIINTLSGGGVSTVGFASEGVELNSGGGLLSRFTTDDRSGDDLDAANTTNRITSLVRKAALGRLTLPCEIEGTERALLVLSGPSEYLNRKGIERGRKWLEEETGSMEVRGGDFPRGEPEVAAAILLSGVTNVPRIKRLQQVAIEAQDNIDDIQSESQDNLEELVEDDEDELEPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVQ5</accession>
    <name>A0A3N6LVQ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-oxoacid:acceptor oxidoreductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_01075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92847">
        <property type="protein sequence ID" value="RQG92847"/>
        <property type="gene ID" value="EA462_01075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="4">
        <location>
            <begin position="14"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="5">
        <location>
            <begin position="235"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="6">
        <location>
            <begin position="510"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="633" mass="69535" checksum="01664EB5F1ABE725" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY54</accession>
    <name>A0A3N6LY54_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor 1A</fullName>
            <shortName evidence="3">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eif1A</name>
        <name evidence="3" type="synonym">eif1a</name>
        <name evidence="8" type="ORF">EA462_00655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3 6">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92774">
        <property type="protein sequence ID" value="RQG92774"/>
        <property type="gene ID" value="EA462_00655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="PTHR21668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="7">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="96" mass="11233" checksum="D6235AE35D686331" modified="2019-02-13" version="1">MSDDGEGGRKNLRMPDDDEVFATVTNMLGANRVKVRCADGTERTARIPGKMQKRIWIREDDVVLVEPWDWQDEKADITWRYEKSEADQLRREGHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYC6</accession>
    <name>A0A3N6LYC6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_16430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86722">
        <property type="protein sequence ID" value="RQG86722"/>
        <property type="gene ID" value="EA462_16430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="72"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="260" mass="28503" checksum="2EBE3E872D6C3E25" modified="2019-02-13" version="1">MSKHSGGGQRRIKSVDNAFRIISALHDQEGSGVTALANRVDMSKGSVHTYLSTLKSQGVVTENDGEYRLGLHLLELGEFAKRQNPVYQCAQDPLEEIATETGELARLVVKEQGYGVYLSKAEGENAIETTIQPGQREYLHCTSQGKAILAHLSEADVHDIVEEHGLPARTEDTITDIDELFDDLETIRDRGVAFSRSEVTRGMRCVASPVHAPDGNVVAAIGVCGPMSRLQGDRFRDEIPELVKNAANIVEINIQMRHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYH1</accession>
    <name>A0A3N6LYH1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92914">
        <property type="protein sequence ID" value="RQG92914"/>
        <property type="gene ID" value="EA462_01445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="284" mass="30300" checksum="EA077C1F230C23E1" modified="2019-02-13" version="1">MNLDLDGGKVLYALGIAFALGALLYFVRDVVFGLSITVTAALLFVLFVAFFVAGLALERDLLDPVAFALAAITYAVFLWYVVSRYQLWETGIFLVLAVSAALFIGLGYGVREYRLAVPLRIAGLIVVALLAVSLVFVGADVAGGGISYGAELEERVTVTVPDDASGGDTVRVERHLGTVTATNEFVFTRPLDMPGVRGCVVGTDEIADEHVHVGYDPGSYQQPEAVGGNDAYSADLTAQFTVDVDADELALAVERGDDCDVTRSEPTLVVVVGEDHERVRYTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYI0</accession>
    <name>A0A3N6LYI0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YjiH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86792">
        <property type="protein sequence ID" value="RQG86792"/>
        <property type="gene ID" value="EA462_16805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="487" mass="52851" checksum="BAAEDB96E9D3FF7B" modified="2019-02-13" version="1">MLDETPWLNDNQDTHRAEAEPEAKTISEVDLVEIRSGPVTKFVIAFLIGFLFFLVPVPWDGQVTVPFDIVVSWITESFPMIAGVYAMALIVAGGLLTTLAELRKREVIDIGEETASRLTLPYWETAAAFWLFRVVGAVLAPFLFLGIGPEWMVSPATGGLVWGTLILSVAVIIPIGAIFINLFVELGGLEFVGTMARPIMRPLFKIPGRAALDSVASWVGSYSVGLYVTRNVFDRGEYSKQDVYIISTCFATVSIGFVGVVAATVDLLELFPIIFVAYLVCIAITGFILVRIPPLSNVPEEYITEPNPETPFRGSPGDYFRFGLSEAVKKADEGGSIIGASVRGFVDGLKLAILILGTILSIGLAAVVIAEFTPTFDIISQPLVPVIQLLGIPDAELVAPATIIGITEMFIPALLVVEADPMARFFIAVLSISQLIFFSAVGPMMMDMFSDIPIRFRDLVLLFVMRTIILVPVIAAMTHLVAMLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYU0</accession>
    <name>A0A3N6LYU0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87853">
        <property type="protein sequence ID" value="RQG87853"/>
        <property type="gene ID" value="EA462_13390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="93" mass="11070" checksum="FDA5C217D6C200A0" modified="2019-02-13" version="1">MMMESRGSHHAKLTQKRADELDIEFVFIPSYSPTLNAIEPLWKDLKREISPEIFADRDHFKEFLTETFLRLSHRLSFANDWIETFLPDVQKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYU3</accession>
    <name>A0A3N6LYU3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93044">
        <property type="protein sequence ID" value="RQG93044"/>
        <property type="gene ID" value="EA462_02195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="25"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="316" mass="35167" checksum="9E3141CE9C77D988" modified="2019-02-13" version="1">MSTADDLSVLHLVTAREVFFDQQIETLEAKGVDCTVCVVPGADQIDGAMGRGRGVTEYLQYVPKVRRALRRGEFDLVHANYGLTAPYAATQFRLPIVLTLWGSDVVGVDGWVTKSCAWRADAVTVRSEEMRELLSRPDAHIVPSGVDMDRFRPIDRTAARERVGWELEETHVLFPYSPDYERKNYPLAERVVDRAGTELGEDVTLQTISGVAHEDVPYYVNAADCLLLTSRHEGSPNTVKEAMACNVPVVSTDVGDVRERLRDVKPSAVGSNATELAECLSTVIESEERSNGREIVREISWDRIGERLVNIYRAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ85</accession>
    <name>A0A3N6LZ85_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiamine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_03200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93214">
        <property type="protein sequence ID" value="RQG93214"/>
        <property type="gene ID" value="EA462_03200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005948">
        <property type="entry name" value="ThiB-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01254">
        <property type="entry name" value="sfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="418" mass="47137" checksum="E9674B7E2BDDD569" modified="2019-02-13" version="1">MRRRTFVRNVGGGSVVGLAGAGCLEREDEAPNGEEEVPPEEDDGTLRIATYSSMIDGENPAGEWLSEGFQEEFPDVEIDWVVPEAGIDHFIQRARLETEIGADVYLGLTISELIRVDDILERRLFETLERDRLERDGRVRDDLEFDDPLDRAIPFDSGYLSLVYDETVLTEPASFEDLTSAEYEDSLLVQDPRHSDPGRAFLLWTVAEYGESFDEYWRALRRNGVQMHEYWSTSYRENYLEGARPMIVSYSTDRVGANAADRDLDGHRIATPDDRGYEIREGGAIFESTDKTALAYEFLDFVLSSDAQAELAVRNAQYPAIEPDYLDLGSEFTAYARRPPETIRFSYDELRDGLNEWLAVWVDEWSDELDEDDPAADLEMNETVSDPPEANETASDSIDPNETMADSTDDDGGTESGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZD0</accession>
    <name>A0A3N6LZD0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87132">
        <property type="protein sequence ID" value="RQG87132"/>
        <property type="gene ID" value="EA462_15360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="221" mass="24092" checksum="8BFB57C697BD339D" modified="2019-02-13" version="1">MTPTDEVDWVRLIERLLYLFPPVIGVGLVGVLREADPGVPGLERGLLLVGTFGYTVLTLALAIALYADARRVRHRAGASGHWKPRPWLNALFALLWAPVAGVFYLSRRHNRFGTRAGWSGWWLVIAASFAATIIGFSMALIAVVFAVPGLLPTAIGFAGAIAFGAFPIAIYQDSAYVCLEGNSWQPNPGLYLGLAFLSLSIPPLQPLVAGYYLFRRRLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0Q5</accession>
    <name>A0A3N6M0Q5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89220">
        <property type="protein sequence ID" value="RQG89220"/>
        <property type="gene ID" value="EA462_12710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="246" mass="27957" checksum="8F3F5A876C8CB42B" modified="2019-02-13" version="1">MKNEVLRIGTAIVAIAAMYSLRYVRLGVSLWKDHYPHPYRTIDVDPSEIEYYGGQFTNNPFRYGGTFSVAYYAGATVRGGRWDNAKKSVTDLPKYTAVVDRYEKGIPWDETGIYDRILELAERGGSYDGCTTRADVSRRYKEIDELYTSIEGDGYSEDDSLDQVCVNIGRDGEIIFNGNGNHRLFIAKVLSLNEIPVRVLVRHEEWMNRRKEIADSSSVQALPESTRDYLDHPDLTDIAPEITADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1Z8</accession>
    <name>A0A3N6M1Z8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89121">
        <property type="protein sequence ID" value="RQG89121"/>
        <property type="gene ID" value="EA462_12170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="128" mass="14631" checksum="B7FE06930D745FA9" modified="2019-02-13" version="1">MAEVVRNIRVELNIPESRHSDVDHTFEEFRQAAQYVADHGWSDDLYHLVKAKNELHQATYTEVREKTDLQSSLVQSARNLAVDALGSCHGSLKDDKNTSNPEFRGSVIVYNGRTIRTFPHHRELRSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2H6</accession>
    <name>A0A3N6M2H6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Shikimate kinase</fullName>
            <shortName evidence="8">SK</shortName>
            <ecNumber evidence="5 8">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroK</name>
        <name evidence="10" type="ORF">EA462_08365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="5 8"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90010">
        <property type="protein sequence ID" value="RQG90010"/>
        <property type="gene ID" value="EA462_08365"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00370">
        <property type="entry name" value="Shik_kinase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010189">
        <property type="entry name" value="SK_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF3">
        <property type="entry name" value="PTHR20861:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005758">
        <property type="entry name" value="Shikimt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01920">
        <property type="entry name" value="Shik_kin_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="84"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG90010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="290" mass="29885" checksum="E5C7A59B2B49CA5F" modified="2019-02-13" version="1">MDGRAVAPAAGTVLNALATGTGAAFAIDLETTATVDLTDTGEIVGEIVGRPDADTSLVERCVELTIETHAESAGLDESAVGARVRTESDVPMASGLKSSSAAANATVLATLDALAVVDSVDRIDACRLGVQAARDAGVTVTGAFDDASASMLGGVTVTDNATDDLLVRDELDRHALVYTPPEQSYSADADVSACERIAPVAELVEELVLEQRYGEAMTVNGFAFCGALEFSTGPMIDALPDAAGVSLSGTGPSYVAVGDRDTLADVETRWTERDGTVRLLQTRTDGTRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M360</accession>
    <name>A0A3N6M360_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90290">
        <property type="protein sequence ID" value="RQG90290"/>
        <property type="gene ID" value="EA462_09945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="421" mass="45843" checksum="0495D7D91C724832" modified="2019-02-13" version="1">MTGTDLRPFVSRSRTLVDSEPPTTARETRRWLVEPFLESLGWDVHADTEAVDDTVEGVHLEYVLAVESIPALFVAVEAYEDSLEESRATALLEAMSWTGVDRAIYTNGRDYALLAGTTNVERLVCRLPSLTDHESSIEHFSRGAIDRRVDELGTAVVARRLALEHSTVLESIVEQLNGAAGGDTQHLEEFEAATDRFLDRLIVAFSDDEYDRLERECVEDGDGEDGGSNAKRQPPKQSDRDSKNQTDRDSKTDPGDVSLQFAESTASREFDDTPDDRSATADRSGGESPVDDGSASNEGSDRDRSEGRTGEYVVRFFGDGGSIGAIGHSSSEQALVHAAEYLFERGLSELTVPWSPADGQPTVLNDGPTRDDGSSMIAPRQLSNGLSIETGGNIEDHAERVRTLAARAGLRAMLTGDWESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3J0</accession>
    <name>A0A3N6M3J0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxypeptidase regulatory-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89771">
        <property type="protein sequence ID" value="RQG89771"/>
        <property type="gene ID" value="EA462_07060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="103" mass="11955" checksum="7E8ECCAD7E87A483" modified="2019-02-13" version="1">MRTERDLILEIDRRETTVETPLTVRVRDRENRPIEDAIVSVGTQRRRTDSAGRCEITIRSPGFWKLTATRRSSNRVSYRPTAALVRAVSRATPVRRTHRLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M436</accession>
    <name>A0A3N6M436_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S27ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps27ae</name>
        <name evidence="8" type="ORF">EA462_14705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86907">
        <property type="protein sequence ID" value="RQG86907"/>
        <property type="gene ID" value="EA462_14705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00777">
        <property type="entry name" value="Ribosomal_S27ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_S27a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022845">
        <property type="entry name" value="Ribosomal_S27ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ribosomal_S27" evidence="7">
        <location>
            <begin position="3"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="44" mass="4974" checksum="0F2C2D811C787BFE" modified="2019-02-13" version="1">MGRHELYGDDGSPESEQCPRCGDTFLADHGDRQHCGKCGYTEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M486</accession>
    <name>A0A3N6M486_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86967">
        <property type="protein sequence ID" value="RQG86967"/>
        <property type="gene ID" value="EA462_15030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="333" mass="37004" checksum="C0BF2E2EA333EDC1" modified="2019-02-13" version="1">MMNRNVGSSRIEITRRNALVGASSLAIGLAGCLGADPDEDDTTAGTDDETDSEGDIDESEFTVATGFLAVWDLTRQVVGDRMTVVDLVPIGEHGHDFDPGPSVVSDIEDADVFIYLREFASWQDSTAAELEGTDGVHVVEASDGIEFFDSPAEDDDEHFWMDPVTCQEAVDTIANALGEIDPDNAAEYEANAASFNEELEELHEEFVDIVDRAQKTQLVVGTHDSFQWWHDRYGLDIYSPIGTSPDNEATPRDVEEIERTMEEHDLEYVLYDVGEPDDLAESIAAETDADVLPISPVETQLPEYDEQDWGYLEHYREINFPTLERALNVTDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M586</accession>
    <name>A0A3N6M586_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87869">
        <property type="protein sequence ID" value="RQG87869"/>
        <property type="gene ID" value="EA462_13480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="337" mass="37675" checksum="A97E321D655FD635" modified="2019-02-13" version="1">MAGCLGDDDDEEIDLVFSSGGFKEITLTELQERGILEEEFDDRGYDVSVSSSSENTSLYASEEADIVDVSPLEAAQLGTERDIQTTVVSVLTPPYPGLMVRADSEYDPDVSGSLEESMQLLADDGLFAIGSWAGGDVPKYRVIMPEMFDLSFEEDDGDFEVTTADYFALPELLADGEVDVISTSGHYGVAPYMTGDEPELTTLFWNMDMVQEMGYGTGIHNAWTAQTDFVDENPEAMEAVTDAWQEGVNILYDEADDLFFQDEYMELIGCQTEEEAEFVYDWAIELNHPESPDNFIVYDDVELTDEFVSNEREYLDRAAEIGTVTADWDEYVQFEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5R5</accession>
    <name>A0A3N6M5R5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Adenylate kinase</fullName>
            <shortName evidence="5">AK</shortName>
            <ecNumber evidence="5 7">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adk</name>
        <name evidence="9" type="ORF">EA462_05180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="5 7"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91370">
        <property type="protein sequence ID" value="RQG91370"/>
        <property type="gene ID" value="EA462_05180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="SSF57774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="211" mass="23651" checksum="D2634B173F7194C7" modified="2019-02-13" version="1">MAQPRILILGAPGAGKGTQSAKISEEFDVEHVTTGDALRANKDMDISEMDTEYDTAREYMDRGELVPDAVVNAIVDEALSQADGFVLDGYPRNIEQAKELEGMTDLDVVLSLDVSEEELVHRLTGRRMDPETGDIYHLEYNPPEDPAVEARLEQRDDDTEETVKERLRVYRENTKPVIDHYESVGVLERIDGEQSPDEVWTDVEATIEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5V9</accession>
    <name>A0A3N6M5V9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl12</name>
        <name evidence="6" type="ORF">EA462_05410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91410">
        <property type="protein sequence ID" value="RQG91410"/>
        <property type="gene ID" value="EA462_05410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05832">
        <property type="entry name" value="Ribosomal_L12p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_L12/P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022295">
        <property type="entry name" value="Ribosomal_L12_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03685">
        <property type="entry name" value="ribo_P1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="115" mass="11608" checksum="F3FFC4D223DBC5DA" modified="2019-02-13" version="1">MEYVYAALILNETGEEINEDNLTDVLDAAGVDVEESRVKALVAALEDVDIDEAVSEAAAVPAAGAAAGGAAAAADDGEDDDGDAEETSDVPDTTDDDEDDEDDDAGGEGLGELFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6C0</accession>
    <name>A0A3N6M6C0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88836">
        <property type="protein sequence ID" value="RQG88836"/>
        <property type="gene ID" value="EA462_10570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="563" mass="64292" checksum="00B27429ED9AE5CE" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6F8</accession>
    <name>A0A3N6M6F8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_06855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91660">
        <property type="protein sequence ID" value="RQG91660"/>
        <property type="gene ID" value="EA462_06855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="304" mass="32071" checksum="594F20C5261EDA7A" modified="2019-02-13" version="1">MSADSTTASGESGNGGGDGNNGGIGRFRGELSYLLTLSRPRFWLYLAGPVLVGVAYAAETTGQLFSPVTVALFAYFLVPANVFLYGINDVYDREIDAENPKKSEREARYGGQRYVPVVVALCAVVPLSFLVVLPTAAWPWLVAFLVLGAAYSAPPARFKTTPGLDSVSNGLYVTPGIVAYAAVSGVQPPVLAILGGWLWAMGMHTFSAVPDIEPDREAGIRTTATVLDENRTYAYCGACWLASAAAFAAVDYRLGLVMLAYPALTAVVAGSSVAVDRAYWWFPAINTVVGAVLTIGGLLVIVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6J2</accession>
    <name>A0A3N6M6J2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91700">
        <property type="protein sequence ID" value="RQG91700"/>
        <property type="gene ID" value="EA462_04675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="104" mass="11544" checksum="67A9AABF86CFE1A1" modified="2019-02-13" version="1">MTDDSDRSLWFPPAMVSEQLQEAGEQVAESQQEMMRRMMQASSSNPLENASAFGPMNMGTATFKARVQSGGRISVPEPERDALDIEEGDIVQTIVVPVKRNRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7B8</accession>
    <name>A0A3N6M7B8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91231">
        <property type="protein sequence ID" value="RQG91231"/>
        <property type="gene ID" value="EA462_04370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="208" mass="22485" checksum="F1604A0FF362AA22" modified="2019-02-13" version="1">MGERLETGIDVLDRKLGGGLPPGCVVAFTASPASQSELLLYELTAARGTLYLSTERSDEAISDAIESSPSSVGSPTIRHITGDSPLEEATTLIEALPDGANLIIDTMDVLERADTDEYTTFLNELKSRMLETDSLAVVHCLKGDTVPANRVRTHHAVDAVFDLRTKIAGTELENHLTVPKFRHGDQPTDTVKLELTEEVAIDTSRDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7U6</accession>
    <name>A0A3N6M7U6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91411">
        <property type="protein sequence ID" value="RQG91411"/>
        <property type="gene ID" value="EA462_05415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01970">
        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="413" mass="41879" checksum="DD2D1B7DD9499507" modified="2019-02-13" version="1">MAVAPVEFVVDPTLSIQLLAWILAGSFLGSLSGLVPGLHANNFALLLAGFAVSIPGPPLFVGCGMLAAGVVHTFLNAVPAMALGVPDAEMAVTALPGHRMVLEGRGYEAIRLSALGSILAVLAAVPLAVPVTWAVTTAYPTIRSNLPLVLAVVVVALVASEQTWRGRFGGLLSFGLAAVLGALTLDLSPDAPLEAGGMLAPLFAGLFGAPVLIDAMVGNGIPRQDGDAITVSRRLVGATALAGALAGAVVGYIPGISAAIAAVAVLVFVPGDSGDRGYIVATSGVDTANTIFALFALVAIGQPRTGVMVAFESVNAPLEIPILLVGVIVAGLIGFALVIVVGETYLELVGKTSYWKISIVVLGLLFGLSYLFTGALGIAVFVAAATIGMVPVRLRARRVHLMGVLIGPLMFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7Y3</accession>
    <name>A0A3N6M7Y3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91461">
        <property type="protein sequence ID" value="RQG91461"/>
        <property type="gene ID" value="EA462_05725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="9414" checksum="82375544605291E6" modified="2019-02-13" version="1">MDSEIKLNEIESAFERLEFPLTDDEVVSEFDGMTLLLADGERNLGELLEASTSDRFDSPADLEAELHNVLPREAVGEPFQSEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8S7</accession>
    <name>A0A3N6M8S7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89876">
        <property type="protein sequence ID" value="RQG89876"/>
        <property type="gene ID" value="EA462_07630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="69" mass="7619" checksum="233540B89A85B791" modified="2019-02-13" version="1">MAVSPSRTDYFVIEALPRRSQWLYLEANGRDVDASRYPLPNGSDGTGYRPNSRGIVTAAPIHTDRVAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M950</accession>
    <name>A0A3N6M950_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium:proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_08400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90016">
        <property type="protein sequence ID" value="RQG90016"/>
        <property type="gene ID" value="EA462_08400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="10"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="538" mass="57062" checksum="087A55464FE1BB9A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M963</accession>
    <name>A0A3N6M963_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90036">
        <property type="protein sequence ID" value="RQG90036"/>
        <property type="gene ID" value="EA462_08520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="42"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="334" mass="36764" checksum="378126F7F9373B21" modified="2019-02-13" version="1">MTEYVSTTPGLFPLPDWAKDDLSDLKGHQKHDLITGDEDDAITAVYEDAREEVLDRQREAGLDRIAEGQLRWDDMLAHPLAVHDSVETEGIVRYYDNNNFYRDPVVTGDLTFSGDVASELETTAELTDGDALQAVLPGPYSLSDLATDEHYGDEAEFLGAVADFLAGEVDAFPDVETLFLLEPSLVENAPDDGQDERASEAIDRVANATDADVVVQPYWGALSEKAYAHLLDADIDAVGFDFVADQDDNVYNIQEYGATDDVSLGLADGQSTLVEDPEAIRDRVDWVFDQIPVSEFETVYLTTNTETFYLPYAKFEEKLAVLAEAAELAEVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9J5</accession>
    <name>A0A3N6M9J5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92950">
        <property type="protein sequence ID" value="RQG92950"/>
        <property type="gene ID" value="EA462_01660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="139" mass="14821" checksum="B0986CBDAD3ABF0A" modified="2019-02-13" version="1">MSTIFSRIVDGEIPARVVYEDETTVAFLDANPMSPGHTLVIPKSEFERLNDVPDDVASDLYASIHRLVPVVEDAVDADASTVAFNNGEAAGQEVPHVHCHIIPRFDGDGGGPIHMVAGEQPELTDDELDGIADDISSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9T0</accession>
    <name>A0A3N6M9T0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EA462_02300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93060">
        <property type="protein sequence ID" value="RQG93060"/>
        <property type="gene ID" value="EA462_02300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="12">
        <location>
            <begin position="353"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="290"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG93060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="464" mass="48676" checksum="58BBF9D85F941966" modified="2019-02-13" version="1">MYVSIVGSGYVGTTVAACLADLGHDVVNVEIDEGIVETINAGEAPIHEEGLAERIEEHAGTSLRATTEYADVRETDVTFLCLPTPQADDGSLELAPMRAGTEMLGEALAPKLEAGDDHLVVVKSTVLPGTTEDVVGPILEETADTTIGTGVELAMNPEFLRMGTAVEDFLEPDKVVIGATSEDAAATLRELYAPILGAATAAGSSGDEPNASDNSSGDDSTAAGSNASDPPDLVETGVREAELIKYANNAFLAAKVSLVNELGNVAKAYGADAYEVLAAVGLDDRIAERFMRSGLGWGGSCFPKDVDALRAGAREQGYEPALLDAAVAVNDAQPRRLVSVLEEHVDLEGARVAVLGLSFKPGTDDVRKSRALDVIDALLERGARPVAYDPVAMENVRSAHPDLPVEYADSAADALEGAEGAVVATDWPEFDDLSVAGMARRVLVDGRRIDVDRGELEVYEGLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9W2</accession>
    <name>A0A3N6M9W2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90356">
        <property type="protein sequence ID" value="RQG90356"/>
        <property type="gene ID" value="EA462_07820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="91" mass="10044" checksum="4CF0CBEB650F352C" modified="2019-02-13" version="1">MQSELADALLMVMQMAVFALALGLTLISFQSYRTNPSKRLESAFIGFAFLSMGVAVTTIVSQISTSLTVFYIVETIPFIVGFGMLYLSLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBH7</accession>
    <name>A0A3N6MBH7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92821">
        <property type="protein sequence ID" value="RQG92821"/>
        <property type="gene ID" value="EA462_00920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="200" mass="23022" checksum="EA1CA821217185FA" modified="2019-02-13" version="1">MTRYILETTVVQKAIRRLIESPVHRMFPGYLSLKQQAEIHGRDDNLPFPYNEFFNQYLRVPGGDKPYLVPFTPLENPSDENLWVSDNVPGTYAPSSLRADSPFTKVVKVEEGGHNSRWKLQPDHWKLARHHLCNGQTIPAESLAVFLFRNYAFETDDPSAYTLIQTFEDEFGYEVSGSQFTTLYQTGDTSINADSFERYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBS7</accession>
    <name>A0A3N6MBS7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91126">
        <property type="protein sequence ID" value="RQG91126"/>
        <property type="gene ID" value="EA462_03780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="52"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="521" mass="57191" checksum="A95938D360434029" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBW0</accession>
    <name>A0A3N6MBW0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase family protein molybdopterin-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92961">
        <property type="protein sequence ID" value="RQG92961"/>
        <property type="gene ID" value="EA462_01725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012368">
        <property type="entry name" value="OxRdtase_Mopterin-bd_su_IorB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036389">
        <property type="entry name" value="IOR_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="233"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="767" mass="82886" checksum="CF74FC370225BFDC" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCJ6</accession>
    <name>A0A3N6MCJ6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="8">HTPA synthase</shortName>
            <ecNumber evidence="4 8">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapA</name>
        <name evidence="9" type="ORF">EA462_05685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 8"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91456">
        <property type="protein sequence ID" value="RQG91456"/>
        <property type="gene ID" value="EA462_05685"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="8">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="309" mass="32959" checksum="40428787275FC818" modified="2019-02-13" version="1">MSTPLDLTGVFPAMCTPFDDDERIDFDTLQTDAQRLETAGVDGLVPVGSTGESATLTHDEHVRVVEAVIEAVDDVPVIAGTGSNNTREALELSERAADAGADGLLLISPYYNKPEQRGLVDHFRAIADAVDLPQIVYNVPSRTGRSIEPDTAVTLAEHENIAGYKAASGDLGLIGEITERTAEADFSVLSGDDALTVPMISVGATGTISVAANVEPERTCAMVGAAIDGDYERARGLHHELGPLFRQLFVETNPIPVKEAMAIRGNMPARLRPPLSRLSDEHRGDLETILADLETERTSVADASSESDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MD68</accession>
    <name>A0A3N6MD68_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91726">
        <property type="protein sequence ID" value="RQG91726"/>
        <property type="gene ID" value="EA462_06400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="228" mass="24811" checksum="51D0FFDFA7E86C45" modified="2019-02-13" version="1">MLSVELHVHSELSYDGRDPVDLILEQAEGIGLDAIAITDHDEIDASLEAAERASEYGLVGVPGMEISSKAGHILGLGLEEPVPPGLSYESTIERIHAQDGLVVIPHPFQESRHGVMARISRDELSEGDAIEVYNSRLLTGRANRQAERFAQSRGLPMTAGSDAHISEMVGQAVTRVDADDRSVDAILEAIREGKTSVEGKRTPWHISFRQAAGGVRRRFRNGVVGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGK4</accession>
    <name>A0A3N6MGK4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93086">
        <property type="protein sequence ID" value="RQG93086"/>
        <property type="gene ID" value="EA462_02455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="205" mass="23506" checksum="88B52864B6A1F702" modified="2019-02-13" version="1">MVQFGLLVKLTLFLSSYVPLFIILSIELSSRQPIIWGDIELPLVSVGFDISLASIILLASSILLILVLMFIIWHHSGHRTEDWRCDHFKQRNELLSSYLLAYVFVFIGLNFSDLGDWLILILFLGMLAVLQMNSEMLHVNPILGLGGYRVYEVESKNQTLLVISRDDIRESIKIPESQRGVKEPEYRNIEIIQLGPNTYMTSHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGL4</accession>
    <name>A0A3N6MGL4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase family protein subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93106">
        <property type="protein sequence ID" value="RQG93106"/>
        <property type="gene ID" value="EA462_02565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="300" mass="32410" checksum="499648A84CB473CA" modified="2019-02-13" version="1">MKPAPFTHHRPDTVEDVLELLAELEEAELLAGNQSLGIVMANRLATPDHLIDLNGVDELAGIDVTDGVVRIGAMTRHRTLERSDRLASVLPMVPEAAEQIAGPSVRNQGTLGGSIGEADPAGNYPAALIALDGSLHLRSLEGRRDVPAEEYFIAYMFTELREDELIESVSIQTDPFPPERTGMAFLELKRAAQTWPTVSAATALRVDDPTAADPIVEDVRIALANAADVPLRVEDAEAVLEGEPMTESGLDEVAELVTAAVMPEGEMHADREYKENVAGEYARRSLETSYQRAVHTADGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MR65</accession>
    <name>A0A3N6MR65_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphonate ABC transporter, permease protein PhnE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phnE</name>
        <name evidence="6" type="ORF">EA462_16490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86733">
        <property type="protein sequence ID" value="RQG86733"/>
        <property type="gene ID" value="EA462_16490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005769">
        <property type="entry name" value="PhnE/PtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01097">
        <property type="entry name" value="PhnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="271" mass="29800" checksum="CDFAFE0A0EEE0D94" modified="2019-02-13" version="1">MSTDNELSQNKSWERPSLFYNKFVKYVVYLSILLFLIWSVWELRISFERFIAGIESSQMLITEMFPPDYGDSTRPRIWSGILETLAMAVIATVIGVGISIPIAFIAAGNLVPKPVYLFGRSIVMISRALHELVLAIVIVTAVGFGPLAGILALTIATPGFFAKLLSEDLEDIDEGQINAIRAVGASRSQVATYGILPQVMPRIIGLTVYRMDINIRASTIVGIVGAGGIGMTLMLSFDTYQYDFTLAILLVIVAIVLLGEMFSAWIRNKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRX8</accession>
    <name>A0A3N6MRX8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87033">
        <property type="protein sequence ID" value="RQG87033"/>
        <property type="gene ID" value="EA462_15445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="195" mass="22297" checksum="2F05888E5A00097C" modified="2019-02-13" version="1">MNLQQHQNRDDMKVWLSQPEVVQLLESAQDTQQRLAFSLGARCGLRSHEVLDVSPDDVVDTDAGTILRVWHGKGDQFRETPVPRDLATTIRTVADVRDASRSEPLLEISTTRSLRRWLTAAADELAETTDDDGWRYLGFHDLRRTWATALAAADVDPLLVIDWGGWNDLETFLEHYRGTYSPEAQQRERQKVAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSC6</accession>
    <name>A0A3N6MSC6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87133">
        <property type="protein sequence ID" value="RQG87133"/>
        <property type="gene ID" value="EA462_15420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="180" mass="19269" checksum="BFBAA13F2576F839" modified="2019-02-13" version="1">MLVVLASVSAMGMGVVGAQENTIDGLENETIENDSAVALENQALIEFTEDTRIVGWEFRDGRVTVALETDRRTGVVVTDALAGIGADGAVQVPETRQFLERDDTTTVTMDVTEFRGGHSVGVSVDGATVRLSSEMDPDENPFEYFGGEQGLFFGMFMSVVMSGGAAGFVLWREETGVMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MU20</accession>
    <name>A0A3N6MU20_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_10820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88882">
        <property type="protein sequence ID" value="RQG88882"/>
        <property type="gene ID" value="EA462_10820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="199" mass="22821" checksum="A480C9D9359F1543" modified="2019-02-13" version="1">MATDLFDEPDGTREEILAATYRALRTHGYADLTISAIGEEFEKSPSLVYRHYESKDDLVLACLAFMLERFEARMTDDEITDSRRRLEAFLHWGLDEMSSTRYRFVTTLVELRLQATHDEAYQEHFTRSDDVFESHVVEIVQSGVDRGDFQECDPERVAAMLVTIVSGALFRRATSDSAAWPADVQAELEAYLESTVYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWZ7</accession>
    <name>A0A3N6MWZ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90012">
        <property type="protein sequence ID" value="RQG90012"/>
        <property type="gene ID" value="EA462_08375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="133" mass="14052" checksum="CDD8AD6DB8F1DEA2" modified="2019-02-13" version="1">MARATVIDGDSALLIERGRGLDIGEWFLAGGYLEYDESPREGAARELGEETGLSVSPTDLTLIGDGFLDAGNGLTMVSFNYAASKVAAEGTLQADDDAAAARFWSRDELKTNAPALRASGLQQLLTAIDELGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0G7</accession>
    <name>A0A3N6N0G7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="4">DERA</shortName>
            <ecNumber evidence="4">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="4">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">deoC</name>
        <name evidence="5" type="ORF">EA462_05315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91392">
        <property type="protein sequence ID" value="RQG91392"/>
        <property type="gene ID" value="EA462_05315"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="4">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="214" mass="22172" checksum="4381D385EECBCCD4" modified="2019-02-13" version="1">MERNELAPLIDHTVLGPETTPTDVRSVLEDARAFGMNACIPPYALEDATSDASDVTIATVIGFPHGQNDHDVKRREGVLAWKAGADELDVVINVGRLKAGEDDAVRAELAEVVAAVPVPVKVIVETALLTEAETERACEAAVAADAAMVKTSTGFADAGATLADVELMSGYLPVKASGGIGSYEEALAMLEAGAERIGTSSGVEILEGAPSRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0V9</accession>
    <name>A0A3N6N0V9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91562">
        <property type="protein sequence ID" value="RQG91562"/>
        <property type="gene ID" value="EA462_06295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="89" mass="10125" checksum="FD4A12FA42AC30A3" modified="2019-02-13" version="1">MAEIPDVDSVESEDEYIHVLFRDPDRYDEIRTPDWADDPAESVSVGSEVRTGELEGSDDWEVTSVLIKKNVGEEKAEEQAREIIEKIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3J6</accession>
    <name>A0A3N6N3J6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92692">
        <property type="protein sequence ID" value="RQG92692"/>
        <property type="gene ID" value="EA462_00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="26798" checksum="23015129F03CB06E" modified="2019-02-13" version="1">MTKTLRTLRTTVASMLAEVGTAVGVFVGLTWFSANAVALGRATDWTPVSDVGIPEEGLWLCVLAAATVGTIWLERDGYRRIRADPTGGSDFAWLSVCYLPVGFLPTAYALALIVELPSFAASLYLLGCGVTAVWLAFYGGLEWLGVERGQLGWTSLVVFGMVGLLFVGGSLNVLGGLLESLDPHRSDPALATASLVGQACALVVGARVSRPNSKLDLQGKVSPALRSKLGFTASSTSDVECESHSENDVDSNAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4F0</accession>
    <name>A0A3N6N4F0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS5 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93052">
        <property type="protein sequence ID" value="RQG93052"/>
        <property type="gene ID" value="EA462_02240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="274" mass="31638" checksum="CB8B8FD657BDDEB9" modified="2019-02-13" version="1">MAINLLDFTRICRRLAKQAFGSYAGKPASGGLPRWVHVVVHCLRLEEGWTYTEVIDRLRLMPAICELLDLLPEALPDPTTFWYSFDRFAMRVWRALLRVSAQQHPNSGHVALDSTFFERGHASHYYLKRVDRTIQTLKVTTLTDVESLAVLDVHCSVKWRHDTILGRKLVRRNADELVSVAADKAFHNWPIRYEYYAESIEPLLLRSGSTLGPHLHNALIRTNGYNQRWMAETSYSSTKRSLGPDVRSLAWYRQFREIVLMFAIHNIEGLSETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NU49</accession>
    <name>A0A3N6NU49_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase/muconate lactonizing enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86650">
        <property type="protein sequence ID" value="RQG86650"/>
        <property type="gene ID" value="EA462_16005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="146"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="386" mass="42729" checksum="2F24CC33B75CA692" modified="2019-02-13" version="1">MVITDVEAIPVEIGLKPLEEDHGLAPYIMGRLEYLESARRVIVKLTTSEGITGWGETAVVHSPSITKSIIETVVADIVVGEPVWKFETLHEYYGSHYIDSSVFLSGVEMAMWDAFGKHNDCPLHQLLGGKQTNRVDFSYCYAINTIEKSTERMRDVRDAGFDVVKTKVGGYGADTAPDDFAYERSIDSDVERLIAMYDAVDGEVELRADANQSWTVSDTTRIAARLEDAGVYLGYIEQPIRTDNVGSYKRLRQRLRTPIAVNEDLYHPGNFYELVREDAIDVGVIDMIPVGGIVPMKKMASLAEEADVSLAHHCGFDLGVKTAAMLHAISTTPAIDLHSDTTYYALEDHIIEDPFEFEDGSLSVPSAPGLGVTIDEEKLDTIRTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYL7</accession>
    <name>A0A3N6NYL7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86152">
        <property type="protein sequence ID" value="RQG86152"/>
        <property type="gene ID" value="EA462_16910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="317" mass="34594" checksum="42A9380DDAFE3557" modified="2019-02-13" version="1">MMESGRDDSTRTTRRTVLAAVGGVAGAGVVGGCLGRAGGSVSVLSAGSLAHTFEDHVGPAFEDETGIAVHGEYYGANAVMRMVEDRTKHPDVIVSADATLLRDRLYGEFTDWDIEFATNSVGLAYARESEFGRRLEDGEPWYELARETDARDLAIGDPNLDPLGYRAVQAFELAEREYDLDGFREEMMELVYEEPEEPQLLTGVESGSRAAAVAYRNMAVDHDIPFFEFPETYSFADPERADHYATVEYTTDEGDYTAEGRPVVYNATVNDEADEPNAGLRLVQFLGDNPERLVDAGLTVGEQIPRASGEVPGAIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYQ5</accession>
    <name>A0A3N6NYQ5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-phospho-L-lactate transferase</fullName>
            <ecNumber evidence="3">2.7.8.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EPPG:FO PEP transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cofD</name>
        <name evidence="4" type="ORF">EA462_08255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = GMP + H(+) + oxidized coenzyme F420-0</text>
            <dbReference type="Rhea" id="RHEA:63444"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:59435"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:59907"/>
            <dbReference type="EC" id="2.7.8.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CofD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.28" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89989">
        <property type="protein sequence ID" value="RQG89989"/>
        <property type="gene ID" value="EA462_08255"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07186">
        <property type="entry name" value="CofD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>7,8-didemethyl-8-hydroxy-5-deazariboflavin</name>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="330" mass="34881" checksum="45FB3E26BAF1D015" modified="2019-02-13" version="1">MVTFLSGGTGTPKLLDGAGAVFSPEETTIVANTGDDIELGGLFVSPDVDTLLFQGGGVLDRETWWGIDGDTHRTNAALSDIASAAGLADGPQYLPEDKQTAGRDLSSWRRFSGSAEFMTIGDRDRAVHITRTSLLDQGHTLSEATERLASAFGLEIELLPMSDDAIASLIHTDEGMMHFQEYWVARRGEPAVETVEFRGSSTAEPAPGVLEALEDTVVIGPSNPVTSIGPMLALPGFADALARTTVVAVSPFLGEEAFSGPAGELMQAVNADPSTEGLADAYPFADAFVIDETDGAEFDRPTIQTDIRIDAPGDAVRVVQAIEQAVEIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYX3</accession>
    <name>A0A3N6NYX3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_16165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86676">
        <property type="protein sequence ID" value="RQG86676"/>
        <property type="gene ID" value="EA462_16165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="147"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="516" mass="56907" checksum="B25DE301F7CBDC50" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0E6</accession>
    <name>A0A3N6P0E6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87938">
        <property type="protein sequence ID" value="RQG87938"/>
        <property type="gene ID" value="EA462_13835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="244" mass="25336" checksum="0B14B555F8E8C2B6" modified="2019-02-13" version="1">MSNQIDGTAVVTGGANGIGRAISVRLAADGAHVVVVDVADGSETVEAIVDAGGSAEYRSGDVTDAESMAAAMDGLEITTLVNNAAYYAPLVDDKKRFDEIDEDEWNDVLSVNVTGAFLASKAALPNIDPGSSIVNIASATVHTGVPGFLHYVASKGAIIGMTRAMATELGDVPVRVNAVTPGFTWSEASQQAGDEYLDQLRARQTLEETIEPEHIADAVAFLAGGESELMTGQVLNVDGGVTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1H2</accession>
    <name>A0A3N6P1H2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88925">
        <property type="protein sequence ID" value="RQG88925"/>
        <property type="gene ID" value="EA462_11055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="212" mass="23019" checksum="D4D1E158E32AFC9B" modified="2019-02-13" version="1">MYATVTTVLESLHPWGRTTEPDGDRSRAASAPPLERAAGSDAETLLRSTSAVVDAGRKDGDRGLRLEPTFRTAWNDRIEEIRETNSRLEELAARLDCERDRLALSVSSDGFVASRDRDRIGCWPSDSAFLADLAATAVLSESDPVWQTLERDERRLVLTGLRLFLERCPNCKGEPTARTNPPVGDGAGGSSVCLECSRCGSRLIAGVEDSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1M9</accession>
    <name>A0A3N6P1M9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating</fullName>
            <shortName evidence="3">6PGDH</shortName>
            <ecNumber evidence="3">1.1.1.343</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gnd</name>
        <name evidence="5" type="ORF">EA462_11455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>6-phospho-D-gluconate + NAD(+) = CO2 + D-ribulose 5-phosphate + NADH</text>
            <dbReference type="Rhea" id="RHEA:33023"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.343"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; pentose phosphate pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.343" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88995">
        <property type="protein sequence ID" value="RQG88995"/>
        <property type="gene ID" value="EA462_11455"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02047">
        <property type="entry name" value="6PGDH_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032883">
        <property type="entry name" value="6PGDH_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="4">
        <location>
            <begin position="165"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG88995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="299" mass="32381" checksum="F98C518871F63423" modified="2019-02-13" version="1">MQLGVIGLGRMGQIVVDRVLGADHDVVAFDLDAEAVATAADAGAESADSISDLVDRLDEEKRIWLMVPAGEAVDVTLEELESHLGPDDVVVDGGNSYFEDSVRRAESCSAAYLDCGTSGGPAGAELGFSLMVGGPEWAYAELESVFDAVATGPDGHERMGESGSGHYVKMVHNGVEYALMQTYGEGFELLHEGRYDLDLESVASVWNNGAVIRSWLLELCEEAFREEGSDLGTVADRIEGGSTGTWTVQEALEQEVPLPLIYTALGERFDSRADDGRFSRRLANRLRYGFGRHEVPRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1Q2</accession>
    <name>A0A3N6P1Q2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PUA domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91459">
        <property type="protein sequence ID" value="RQG91459"/>
        <property type="gene ID" value="EA462_05700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029402">
        <property type="entry name" value="TGT_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038250">
        <property type="entry name" value="TGT_C2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14810">
        <property type="entry name" value="TGT_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PUA" evidence="2">
        <location>
            <begin position="88"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="165" mass="17824" checksum="F51AADD13728E9D3" modified="2019-02-13" version="1">MSESDEPADGEADLSSLRTIADYQFGAGAGVTLFSPTESLTIKRTTSGRPQQVHCADGRIVSFGVDGRFTLGIEGGRRLSRALSHPAYRVVVDDESEPFVREEKNVFAKFVLESDPEIRPGDEVLVVHERGELLAVGRAELDGTAIEDFETGMAVAVREGEPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1R5</accession>
    <name>A0A3N6P1R5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91479">
        <property type="protein sequence ID" value="RQG91479"/>
        <property type="gene ID" value="EA462_05820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="98" mass="10858" checksum="A716E345D6A004B9" modified="2019-02-13" version="1">MGHSYRTEPDPPEEPTERSESDARETTDALRSGAWVAISSIFGLVFLVATLTQLIRVLVPTSPYGGPTLLNWLLFVAVVLAFAVAVTWSWRERTTIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P272</accession>
    <name>A0A3N6P272_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF58 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_12790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89235">
        <property type="protein sequence ID" value="RQG89235"/>
        <property type="gene ID" value="EA462_12790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="3">
        <location>
            <begin position="219"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="522" mass="56345" checksum="07A5C34288E83A25" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P2B1</accession>
    <name>A0A3N6P2B1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91709">
        <property type="protein sequence ID" value="RQG91709"/>
        <property type="gene ID" value="EA462_04960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="70" mass="7973" checksum="CC1A8E6E3C011401" modified="2019-02-13" version="1">MKVVYKPGNTYEEINCFDFREYDYGIVLHDENGYNIGYVPHEILSHIEPHAGEAVAFEDGEPPIRGDDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P2B9</accession>
    <name>A0A3N6P2B9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91719">
        <property type="protein sequence ID" value="RQG91719"/>
        <property type="gene ID" value="EA462_05735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043815">
        <property type="entry name" value="DUF5797"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19110">
        <property type="entry name" value="DUF5797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="167" mass="18774" checksum="7827B83C76FBF631" modified="2019-02-13" version="1">MTLSEEARERLADVVELQPTKNAELQDRWGMESGSEVHQYLEGELGDYYFRDDNSLIRATSEAADLVDVEPGIETGPDEEGPPSRIRVPELQSRIVAVLAAPDEESESVVSVLHKLRDEFDVDPDTEDVRSGLQSLRRKDVVEVEYRTVPTFRLTVSRDDLEVGVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P452</accession>
    <name>A0A3N6P452_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit CofH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cofH</name>
        <name evidence="8" type="ORF">EA462_00010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92659">
        <property type="protein sequence ID" value="RQG92659"/>
        <property type="gene ID" value="EA462_00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="77"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="421"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="464" mass="51374" checksum="C1CC23283131FBCC" modified="2019-02-13" version="1">MERPVTEADLTFEHVPETDQSFENALAKARGRDRLTVDDAIELLTTGTDIPGIDRRRKEQVLEAADRRRADVVGEEVTFVANLNNNVTTACNVGCLFCNFKDAAHTFETEYAEESGPETAGFTKTPEESREIVEDAVSRGIYEVTSVSGLHPAFALDEEHLEILETHPERKAVNYKPPERYVTDPGTYAEQLTAMSVDDVHVHSMTPEEAYHARRGTEWSYEEVYARLSEAGLDTVPGTAAEILVDEVRDVICPGKIDTAGWLEAMEAAATVGLGLTATIMYGHVENEAHRALHLKRVRDLQERVGGAITEFVPLSFVHQNTPLYEHDVVSGGASTDEDELLIAVSRLFLDNVDHIQSSWVKYGNEQGLKMLSCGADDFMGTILSEEITKRAGGEYGEFRSVTDYVELISSIGRVPVERSTDYETRRVLDPEEPPFGPELGPQANGTPLLTRAERSERDVLADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P467</accession>
    <name>A0A3N6P467_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydantoinase B/oxoprolinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92689">
        <property type="protein sequence ID" value="RQG92689"/>
        <property type="gene ID" value="EA462_00175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase_B" evidence="2">
        <location>
            <begin position="29"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_B" evidence="2">
        <location>
            <begin position="173"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="587" mass="62075" checksum="3D79A0ED68D53D50" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4D0</accession>
    <name>A0A3N6P4D0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_00680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92779">
        <property type="protein sequence ID" value="RQG92779"/>
        <property type="gene ID" value="EA462_00680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="3">
        <location>
            <begin position="267"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="458" mass="46787" checksum="D6CB2550FCF61320" modified="2019-02-13" version="1">MGKRREKHTVTGEWRRRPTSGTGTNSTVERASLPTETNEFIGSEALAAVVAADTGDRDRVVLAAVVFAVMFSQLLLYPGIATLVDVLGADASGSPLTETTLDAGMWFFVAEFAAYIAFVGLWGIVSDVTGRRTPFIVVGAVIGALSYGALALVPAVGSVPFEGVLALRVFQGAMTVGAFSLTMTMLMDLPGGHGKNMGAAGIAIGLGAALGAPVGGQLTEVDPVAPLVVAAGLLLTVGVVVAAVDDRTPDVHRSAGALLEGIKRRPSLSVPYAFGFVDRMTAGFFALVGTLYFQETFGLEAGTTGLLLACFFAPFALLQYPFGSLSDRIGRTIPIVLGSMCYGVGILVVGVAPTVATAAIAMATIGVLGALVSPATMALVTDLADEDERGLAMAGFNLAGSLGFLGGFLVGSIVAGQFGYDLAFLIVGGLEIAIAIVAAPIVFRLSIASDGLGPTECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P524</accession>
    <name>A0A3N6P524_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prephenate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pheA</name>
        <name evidence="8" type="ORF">EA462_02800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93149">
        <property type="protein sequence ID" value="RQG93149"/>
        <property type="gene ID" value="EA462_02800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="185"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="270" mass="29199" checksum="4B30C138FB0F2C2C" modified="2019-02-13" version="1">MAVITLGPEGTYSHRAARAIGDEIEFSQSVTSIVDAVATGEHDRGVIAIENSIEGSVTESLDALAEYDVAVVREIVTPVRHALLAQGPTFETVASHSQALAQCRTYLEREYPDAALEAVASTAQGVDFARTDASVAGIGHPANADDGDELEVLAEDIQDQDSNSTRFFAIAPTEDRSTGGGKTSLVVYPNANYPGLLLELLEPFADQDINLTRVESRPSGRRLGDYVFHVDFEAGLYESRTNEAIEELEELAENGWVRRLGSYDTEHVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P618</accession>
    <name>A0A3N6P618_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit Rpo4</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpo4</name>
        <name evidence="3" type="synonym">rpoF</name>
        <name evidence="4" type="ORF">EA462_03940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91155">
        <property type="protein sequence ID" value="RQG91155"/>
        <property type="gene ID" value="EA462_03940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00864">
        <property type="entry name" value="RNApol_arch_Rpo4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010924">
        <property type="entry name" value="Rpo4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39646">
        <property type="entry name" value="PTHR39646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005053">
        <property type="entry name" value="RNA_pol_F_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="118" mass="13809" checksum="3B5325F27693DCA4" modified="2019-02-13" version="1">MTIFKEIVDEEFLTVSETKELLADIESERALDEDRELPYELARAIEHVNRFTHLEPEEAQQLVEDLRELEKVDEPTAYKIANLLPRNRDELRSVYAQQRYSLSGDELDDILNAVARYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6U7</accession>
    <name>A0A3N6P6U7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoxR family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91605">
        <property type="protein sequence ID" value="RQG91605"/>
        <property type="gene ID" value="EA462_06540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="40"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="234"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="324" mass="35517" checksum="CC806F634D817A66" modified="2019-02-13" version="1">MNVTQASDECTAILETIGRSVICDREFIEEILVAVVGRGHVLVEDVPGTGKTLTARSVAAALGLSFSRIQFTPDLLPSDVTGTHVFDERERAFEFNEGPIFANVVLADEINRAPPKTQAALLEAMEEGQVTTDGETRALPDPFFVIATQNPVEQEGTFPLPEAQVDRFLVKCSMGYPDEEGEIELLRRRASRETTSPSVETVLEPEQVDRLRSVPESIRVDEDLLEYVAALARKTRTDGRVEVGVSPRGTQRLFEAARAYATVVGREFVTPDDIKRVAHPVLTHRLVLTPDATVNAVDRRRIVDDVLESVPVPTLEATADAGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9L8</accession>
    <name>A0A3N6P9L8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92945">
        <property type="protein sequence ID" value="RQG92945"/>
        <property type="gene ID" value="EA462_01630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="106" mass="11311" checksum="77F11DCEEE4FC27C" modified="2019-02-13" version="1">MPSGDEPADATESRQPADVTTFDPSAGQQPSLAVPVAVASFTEEDPLELTPLYEVVEPDALDSLFEHAARTDGNGVHQLWFRYEGVDVGVRSDGQIEIDAPTADPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHJ5</accession>
    <name>A0A3N6LHJ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF488 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_17120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86190">
        <property type="protein sequence ID" value="RQG86190"/>
        <property type="gene ID" value="EA462_17120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="143" mass="16107" checksum="FF3E5525FCD5E287" modified="2019-02-13" version="1">MEHGRLTDTYVAAVQHDLVDLPEGTTLVGVVRKPTAWFHAAVDENRPSLGPPRTLLESTRETVDDLKMRGICDEGAHNAAWEQVEFDERYRTYIETSPEAQAALSDLEGRLASGESLALVCFENTDKKRCHRSILRDRLDERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ12</accession>
    <name>A0A3N6LJ12_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatininase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_13135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87811">
        <property type="protein sequence ID" value="RQG87811"/>
        <property type="gene ID" value="EA462_13135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="268" mass="29136" checksum="9BCE0F654A76A43B" modified="2019-02-13" version="1">MFEASAGSRTAWGGCTYDEIDAIANEDGSILVLPVGSVEQHGNHLPVGTDTILANEIAALGAERVADEIPIVLLPPFWSGYSPHHLTFGGTVSLEFDQMLETLEEIAETALENGFDAFLFVNGHGGNQPVIDSAVSTVGSQQPNVETLGITYFQLAKSFIDEIRESDPGGMAHGGEFETSLMLYLREELVHRDELEGTYLDEPYDLGTRDLLSGGPLSVYREFDAYSETGAIGDPKLASAEKGERIYHRLGDELEQLLSDIHQQCVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ82</accession>
    <name>A0A3N6LJ82_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87941">
        <property type="protein sequence ID" value="RQG87941"/>
        <property type="gene ID" value="EA462_13850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="51"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="481"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="574" mass="63990" checksum="0E16F6B351B73133" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJT6</accession>
    <name>A0A3N6LJT6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_17085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86184">
        <property type="protein sequence ID" value="RQG86184"/>
        <property type="gene ID" value="EA462_17085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="258" mass="27797" checksum="58A5F23659D9227F" modified="2019-02-13" version="1">MHTVSHHGRETAYEVTDRGGNGPSVCCVHGTGSTHARWRAQLPLADRNPLVALDLSGHGSSDDIEAEAGYSALSAYADDVLAVTDATGASVLLGSSLGGAAIMHAIVERDVRPDAAILTGAGARLGVLEDLLIWLETDFDRAIEFLHEPGRLFSDPEPALLERSKAAMSDCGQPVVRRDFETCHTFDVRSDLSKIDVPVLAICGERDQLTPPWFHEYLADEIPDASVVTIEDAAHLVMLEQPAAFNETVREFLETVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJU0</accession>
    <name>A0A3N6LJU0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89033">
        <property type="protein sequence ID" value="RQG89033"/>
        <property type="gene ID" value="EA462_11675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="166" mass="18077" checksum="9F25D0F16C3BB976" modified="2019-02-13" version="1">MRVSIPGVPGVYYDTDTGTTALAAVTTAAGRRAPKPQGYAVQLVPYLWSFDVDLQEVPNDHPIQYLHPEGAVSMAELSSDRTDRRASTELESVLRFVWSVNRELESATDRVLGGSAGHEGVVIEIEDGRVGVDGDRLETDAFDVDGRASEEHDDRDSDESGSVDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJY4</accession>
    <name>A0A3N6LJY4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89083">
        <property type="protein sequence ID" value="RQG89083"/>
        <property type="gene ID" value="EA462_11945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="135" mass="15060" checksum="7236F61CE33FB60B" modified="2019-02-13" version="1">MDKERFPRWGWLLIGLFGATMVANLVNIAVLGPAGLSEEYFVVTIITGMSLVLIYTGVWYDDERAQYWEHSTERVFGDVVFVVIGAAVGSALAIVAISDIGLSRIVQDVIAMVAGFVLSWGLFWWRNPELYRAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK85</accession>
    <name>A0A3N6LK85_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88998">
        <property type="protein sequence ID" value="RQG88998"/>
        <property type="gene ID" value="EA462_11470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="184" mass="19504" checksum="418EE2262E60F267" modified="2019-02-13" version="1">MMATTHVFAGLAAVAPVALVVPEFAGPLALGAVVGAIAPDFDLVLEHRRTLHFPVAGLVIATPLAAVALVATATFTVALAAVAFTAWLHAASDALGGGPEMDPWNDRTERAVYDHVRGRWIEPRRVVRYDGAPEDAILALSLAAPVLVIFDGWVTAVVAVGVPITVVYALLRRRLTAWTPDWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKG7</accession>
    <name>A0A3N6LKG7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89293">
        <property type="protein sequence ID" value="RQG89293"/>
        <property type="gene ID" value="EA462_12390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="611" mass="70208" checksum="AA438FC87535A73A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKH5</accession>
    <name>A0A3N6LKH5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="10" type="ORF">EA462_12315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89148">
        <property type="protein sequence ID" value="RQG89148"/>
        <property type="gene ID" value="EA462_12315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="119"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="9">
        <location>
            <begin position="119"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="9">
        <location>
            <begin position="213"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG89148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="302" mass="33568" checksum="F15EBA9D7A188885" modified="2019-02-13" version="1">MKSSTLTICSECGGRLRETGTETVCEDCGLVSGEDALDRGPEWRSFEDSETDRRRTGAPLTRSRHDRGLSTEIGYRSGSDSYRSRLTGRKRRQIARLRREHNRARISSKAERNQIYGFAEIRRMYALLSLPDVVREQSCALFKSAQSEGLFQGRSLEGFAAASVYATCRTRSIARTIDEIEDVARADEGELKVAYDALNRELGLPTGPIDPAQYLARYASKLDLERAVERRARDHVATLDGRGLIGGRNPSGVAAACLYAAARERNEWTSVTQAEVADVANVSPVTIRSTVTDVRDFRSPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLF3</accession>
    <name>A0A3N6LLF3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89803">
        <property type="protein sequence ID" value="RQG89803"/>
        <property type="gene ID" value="EA462_07225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="144" mass="15646" checksum="95B78B5C7503C558" modified="2019-02-13" version="1">MVPTTQGSVLQHRTRAVLDVGRRITVNRLVGEIILGLWALQLVAIGLGYVFITASVEDSLAFEVVQFIWFVFTYLPASIFSILVLNPIMDQTFYQTASALGPSGSAGLFVVSLTVMYAVIGIAVSLFTLSGKNALQTVSEWWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLP4</accession>
    <name>A0A3N6LLP4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89798">
        <property type="protein sequence ID" value="RQG89798"/>
        <property type="gene ID" value="EA462_07200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043828">
        <property type="entry name" value="DUF5805"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19121">
        <property type="entry name" value="DUF5805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="130" mass="14540" checksum="AB5E5C5A61A89EB4" modified="2019-02-13" version="1">MTDRPDTSRKSIKTYVPAYQKDEWRSHADELDMSQSEFVRTMVQAGRKGFTSGSEEPDSPASDPGGNVLETRVLELLSTDTYSWDELLEAVSDDIESRLDETLEDLQSTNRIRYSGRHGGYTLVGDGDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLR0</accession>
    <name>A0A3N6LLR0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89963">
        <property type="protein sequence ID" value="RQG89963"/>
        <property type="gene ID" value="EA462_08115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="91" mass="10285" checksum="507897939BF28165" modified="2019-02-13" version="1">MCDRFGNCSNDGTCQLVLRNRITGMERVEYHCKAHLVLRVWELEDDDAHDVIDATPLNRSSSPTDQPEPGQRVQSTDPSPESIEPASNRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLR6</accession>
    <name>A0A3N6LLR6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bacterio-opsin activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_08175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89973">
        <property type="protein sequence ID" value="RQG89973"/>
        <property type="gene ID" value="EA462_08175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAT" evidence="5">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="4">
        <location>
            <begin position="156"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="236" mass="25423" checksum="DE841E9F13639B44" modified="2019-02-13" version="1">MSVIATISVPTTEFPFGTLLEADPETTLTVETTVPTSTGAVPYLWISAPQPDCVVGAIDAASTVESVSIVDRMNGHVLVSIDWIDRINGVLRAIERGDAIVTSAVGTHEGWSFRLRFPAYEELSTFYTDCADRGISIELVQLHETVSPDCDGRFGLTAAQRELVIAAYESGYFDVPRETTLVELGDRFGISDSAVSQRLRRGLAALIDTTMAVETDTQKSVNSDGQATPETGTETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMC9</accession>
    <name>A0A3N6LMC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_09220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90158">
        <property type="protein sequence ID" value="RQG90158"/>
        <property type="gene ID" value="EA462_09220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="3">
        <location>
            <begin position="173"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="566" mass="62734" checksum="64DEE9CE111C492E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMG0</accession>
    <name>A0A3N6LMG0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90283">
        <property type="protein sequence ID" value="RQG90283"/>
        <property type="gene ID" value="EA462_09910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="451"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1124" mass="124858" checksum="37BBA93BF7188089" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMG1</accession>
    <name>A0A3N6LMG1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper resistance protein CopD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88997">
        <property type="protein sequence ID" value="RQG88997"/>
        <property type="gene ID" value="EA462_11465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="154" mass="16126" checksum="52C2CD32E90E2391" modified="2019-02-13" version="1">MVDTFLAQTTHLVFASIWAGSVFYVAVVVLPLARDGAFNTTKPLEAISGKLTMISRVSALVLLLTGGHLAGTRYTAESLFNSINGQLVLVMVALWLLLAALVEIGAKRLEAGLNGKKLREPAADVLGLYRVAAVVAIALLVVAGAITTNVQAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LN03</accession>
    <name>A0A3N6LN03_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0173 metal-dependent hydrolase EA462_14910</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0173 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86945">
        <property type="protein sequence ID" value="RQG86945"/>
        <property type="gene ID" value="EA462_14910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00457">
        <property type="entry name" value="UPF0173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022877">
        <property type="entry name" value="UPF0173"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="7"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="238" mass="25612" checksum="69B2F0EB1DD5AE6A" modified="2019-02-13" version="1">MELTWHGHSTWYVTVGETNLLIDPFFDNPQTDLEPSDVGEPDYVLLTHGHADHIAHAGAFSDATLVATPEIVSYCQEEFGFEDAVGGMGMNLGGTVECGDAFVTMTRADHTNGIMTENDTSGGMPAGFVISDTHPTADDDGTTVYNAGDTSLMSEMRDVVGQYLEPDAAIVPIGDHFTMGPQQAAIAVDWLEVDHAFAQHYDTFPPIEQDPEDFVSEVGATGSDAEVHVLEADEPFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP00</accession>
    <name>A0A3N6LP00_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91138">
        <property type="protein sequence ID" value="RQG91138"/>
        <property type="gene ID" value="EA462_03840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="112" mass="12233" checksum="C80A7171142D2AAA" modified="2019-02-13" version="1">MSEDGIQRASDVGSADAPPIKEKPYKIIFEANKCFGAGKCAEVSDNWEMSIASGIAKPNTYFFEEADLEHNVRAAEICPAKKDEGCIHVVDRRTDEEIAPDPDGDGTLSVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP23</accession>
    <name>A0A3N6LP23_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_04005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91168">
        <property type="protein sequence ID" value="RQG91168"/>
        <property type="gene ID" value="EA462_04005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="27"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="386" mass="42609" checksum="B4A6441D3594E6EB" modified="2019-02-13" version="1">MGNGRLLTTTADEPTRESTLSTDDVVLELDTVAKRYGSETVISSLSLTVRDGEILTLLGPSGCGKTTTLRLIAGLEDPNGGQIRLEDETVAGDGQFVPPDEREVGVVFQEFALFPHLTARENVAFGLQEWTKQERESRVQELLELVGLESHGGHYPEELSGGQQQRIALARSIAPEPEMLLLDEPFSNLDVDLRVEMREEVRRIIKETEVTAISVTHDQEEALSISDRVAVMNDGNIEQIGTPERVFQEPKSRFVAGFLGHASFLSGEVRGDHVDTALGRVLRDDVNGLAHQYDGTDLDLLVRPDDVTAFPADESQANGRVVYRRYLGPTVLYRVELDSNETIECMHNHSDRIDLDERVAVRVTADHELAWFPAGQRGKGAATPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP35</accession>
    <name>A0A3N6LP35_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89837">
        <property type="protein sequence ID" value="RQG89837"/>
        <property type="gene ID" value="EA462_07410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="195" mass="21469" checksum="D3A50F1074991404" modified="2019-02-13" version="1">MARGQIHALEGILAAVLLVLSLVFALQVSAVTPMTESTSSQHIENQQRAVGQGLLEAAAEDGSLKTALLYWDNDAETYHGSNEDHRYTSGLPDDLRLGSELRRTITERGIAFNLHVNYVDDGEISSRTLVTQGEPSDHAVTVTETVTLFEDDTLFDSSGDPTDVTLQDAEEFYVPNEADGALYNVVEIELRLWRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP90</accession>
    <name>A0A3N6LP90_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88087">
        <property type="protein sequence ID" value="RQG88087"/>
        <property type="gene ID" value="EA462_14660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="345" mass="40129" checksum="28B72663221D9D77" modified="2019-02-13" version="1">MTTVRHFPYEDAPTQQYTAQFHTHPNEPPRNGYRYPAHKLADIYDGHRCDILAISNKKNGGEMPWPWTEWSEFPYDWEDRYPIQNHGEGPADQELDLLAIRGNYDKVDNVFNTIESDFVNEDLVGGMDRVEAAVEQNALCWWPHPGRYWNVEDTHEYDLEDLIEVFENYPSDELLGIEVWNQGYRYRDLYLYDHLLTEFYRREEGFRPIYSLAVDDMSGSGSKEDDFDLNSGYCELFMDELTVPAFRNAMENGHWYPSVARPTGELPPVIESVEHDEADGRLRVNASNYDHAVWISEGEVIETGTELDYESNDEVRSYVRAHLSRDGRKGEATTQPIAFEVNNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPG2</accession>
    <name>A0A3N6LPG2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps14</name>
        <name evidence="5" type="ORF">EA462_05095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds 16S rRNA, required for the assembly of 30S particles.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91353">
        <property type="protein sequence ID" value="RQG91353"/>
        <property type="gene ID" value="EA462_05095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_A">
        <property type="entry name" value="Ribosomal_S14_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="40S_S29/30S_S14z"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023676">
        <property type="entry name" value="Ribosomal_S14_type-Z_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="PTHR12010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="60" mass="7070" checksum="322C0E71B79D9BE3" modified="2019-02-13" version="1">MSESEHENDQTGEHAAKRTGQFEQCQRCGRKQGLVGKYDINLCRQCFREIARDMGFKKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPL1</accession>
    <name>A0A3N6LPL1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstA</name>
        <name evidence="8" type="ORF">EA462_10390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88804">
        <property type="protein sequence ID" value="RQG88804"/>
        <property type="gene ID" value="EA462_10390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="83"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG88804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="300" mass="31882" checksum="2281DFC93C2C7DBB" modified="2019-02-13" version="1">MSAQNPFADGTREIERKRLIGRVFVAVCLASTLVGIVALVALLADVLSESWGWVTWEFLTYPPSQVIENFLPDGRGAGIYPALVGSIFLIALTAVFTVFLGVGAAVYLEEYAADSRLSSFIEANIANLAGVPSIVYGLLGLAIFVRAAQLGSSLIAGALTLTLLILPIVIVSTQESLRAVPDSQRRAAYGVGATQWQVIRDVVLPRALPGIMTGTILSLSRAIGETAPILMVGAATSLFVAPDGLTSPFSAMPMMIFEWASLPEPEFQHVAAAGIVVLLTILLLMNAVAILIRNRYDPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPN0</accession>
    <name>A0A3N6LPN0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91458">
        <property type="protein sequence ID" value="RQG91458"/>
        <property type="gene ID" value="EA462_05695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="9"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="165" mass="18439" checksum="5A4E5A3258C7D900" modified="2019-02-13" version="1">MTEIHPDQRVAVLVDAQNLYHTAQSLHSRNIDYSALLEKAVQDRQLTRAIAYVIRAEAPDEESFFDALVDIGFEAKIKDIKRFSDGTKKADWDVGMSLDAVTLANHVDTVVLCTGDGDFSRLCSHLRHEGVRVEVMAFESSTADELVDAADTFLDLGERHETFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPP4</accession>
    <name>A0A3N6LPP4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91478">
        <property type="protein sequence ID" value="RQG91478"/>
        <property type="gene ID" value="EA462_05815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="258" mass="27095" checksum="2720234BF9021611" modified="2019-02-13" version="1">MTDSTIDDKPGDGGFDVGSSADELFGEIEEEPLEADVDRSDEDGDETGTEHEGEPADEDDTGVEDQTAAAVFGQLKNEVVADGADGVLEDETPEEIIAGADEPDPEPAEPIDDDLLADEDELADLLLTERTKGEEFLWVDSGSSTEDTGTEPDTAPGSDAKSQQGETSEVDLEAETAATPESIADENVDSGSNGRDSSHTDDAEAMDDRVDGGLEVTDERMDEGSDVDSPQDDSDVSETDGDTGGVIGWIKATIGRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPT8</accession>
    <name>A0A3N6LPT8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91538">
        <property type="protein sequence ID" value="RQG91538"/>
        <property type="gene ID" value="EA462_06150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="60" mass="6597" checksum="DD0AE10926CA88D1" modified="2019-02-13" version="1">MKRWWRISNATLLRPKAEKARGGPIGCRNCFAGQPSSVIECLLVAQSTSTDSISRHSGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQG3</accession>
    <name>A0A3N6LQG3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaerobic glycerol-3-phosphate dehydrogenase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_12625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89204">
        <property type="protein sequence ID" value="RQG89204"/>
        <property type="gene ID" value="EA462_12625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="488" mass="54170" checksum="BF349D4A43688790" modified="2019-02-13" version="1">MSDAEQPIDGGAPDEGDDEFEPIQVFPEAEEMDLRPGADDCYKCSTCDTNCPVAAVDDEFPGPKFQGPEQWRLKRQDDHDIDDSVMKCSNCMRCDSACPSSVPLSQMHNTARGEYVEQTMSKLSREYLRNRMLANYRRFAPLGATFPRTANFVLGLSITKWLGEKTLGITSERELPAFATETFREWWEKRGGNAASKRRAQDAREKRGGNAASKRRAQDAREKRGDNAASKRRGESNQPSEDKRIAYFHGCYSNYNTPEVGKALVRVYERFGYEVLVPDQHCSGTPMFANGMLEDARRAAETNVAELADAIENGADIIASCSSCSMSIRQEYPELFDFEGTEDVSANTWDAVEYLRVHEDLEAELEGTSVGAEFDDFVYHAPCHSRNQGLNGQTIEVMDAIDGIDVHDVGDSCSGISGTYGWKAENYETSMKIGEEMFEHMADADARTGLTECPTCSMQMEHGTGYEITHTLEVLEAALVGDSSETDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRK7</accession>
    <name>A0A3N6LRK7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Deoxyribodipyrimidine photo-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_07075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89774">
        <property type="protein sequence ID" value="RQG89774"/>
        <property type="gene ID" value="EA462_07075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="479" mass="54078" checksum="5ADE1EFC14E21A08" modified="2019-02-13" version="1">MGIHWHRRDLRTSDNLSLARAAESGDPVVPLFVFDPTILEHATPPRVACLREAVGALREWYLDLGSDLLVEYGEPSDVLPRVAAAYDADAVYWNEDYSGLAGERDRAVTAALEDEGFVCKTAHDAIHHEPGSITPNSGDHYSIFSYFWKKWRDRDKREPVDPPEPTDLAAVPSADDEVSTDSESIEGIPSLSDLGFEEPDATLPTVTPSAARERVSSFCSGPIYEYEGTRDYPATGGTSRLSVHLKWGTIGVRELFEATQRAADRASSTTDRESVESFQRQLAWREFYAHVLSYNPGTVAENFSQFDREIQWRDDPDELEAWRNGGTGYPIVDAGMRQLVDDGWMHNRVRMLVASFLTKDLLIDWREGYDWFRRKLADHDTANDVGGWQWAGSTGTDAQPYFRVFNPMKQGREYDPDAEYIRAYVPELEAATPDRIHGWHELSGTERERVAPSYPAPIVDHAERRERAIATFKRAKGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS15</accession>
    <name>A0A3N6LS15_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90014">
        <property type="protein sequence ID" value="RQG90014"/>
        <property type="gene ID" value="EA462_08385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="79" mass="8965" checksum="C565D36CCF0489E2" modified="2019-02-13" version="1">MTKVDVRDLQTNETDDRGRIYLGTKYANKRVTVAVVEVESDHPDEDELAAAYREASESAEELAEEWDDASDDAWSELDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS43</accession>
    <name>A0A3N6LS43_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydantoinase/oxoprolinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_00170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92688">
        <property type="protein sequence ID" value="RQG92688"/>
        <property type="gene ID" value="EA462_00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="3">
        <location>
            <begin position="23"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="2">
        <location>
            <begin position="217"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="695" mass="73070" checksum="BC7BED8C21BB1F07" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSB2</accession>
    <name>A0A3N6LSB2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR00341 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91427">
        <property type="protein sequence ID" value="RQG91427"/>
        <property type="gene ID" value="EA462_05500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="PTHR20992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="428" mass="44891" checksum="2F8FE56EE870288B" modified="2019-02-13" version="1">MRLVQVFVPKGDLELVLETADATGLDYAVSEETSRGEFEALVSIPVPPAAVEPLLAELRAAGFDEDSYTVVTAAETIVSSRTDQLIGQFSGTRISREELQTRAEDLAPAASTYFVLLVVSTVIATAGLLLDSAATIIGAMVVAPLMGPALAASVGVVVDDGELATRGVLFQVTGLLATVLTAALIGWLLRGTVLLPPGFDITTVPQIRERITPNFLALFLALGSGVAGVVSLVRNVGSVLVGVAIAVALVPPAATAGLGIAWGHSIVVVTAGTLVLVNMLSINLTALIVLWLSGYRPHRRASVEHVYGRVRSRIVVLVVAIVVLSMVLGGVTYGTYQTAAVEHDVGTELEAMSDDPVFGDLRFQEVAVEYELIDVYTGTEPAVTVLVERPPGEQEPAGFADTVRERLEDATGGDLTVTVELVDTRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSK9</accession>
    <name>A0A3N6LSK9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rubrerythrin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91497">
        <property type="protein sequence ID" value="RQG91497"/>
        <property type="gene ID" value="EA462_05920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="46" mass="5150" checksum="AC390FABC95A9296" modified="2019-02-13" version="1">MVYTDPYTPDRSHYECCDCGYRETTDTLGACPECGGRTQNIAIGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSV4</accession>
    <name>A0A3N6LSV4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93063">
        <property type="protein sequence ID" value="RQG93063"/>
        <property type="gene ID" value="EA462_02320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="66" mass="7228" checksum="B56287CDF9D13F19" modified="2019-02-13" version="1">MKIATKTTSAARRRAAPTYGTCSSRALYGARHVSCTELVRVLYGARHVSCTELVDTPLIPATEYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT16</accession>
    <name>A0A3N6LT16_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosomal protein MC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_02795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protects DNA against thermal denaturation and modulates transcription.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93148">
        <property type="protein sequence ID" value="RQG93148"/>
        <property type="gene ID" value="EA462_02795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008674">
        <property type="entry name" value="MC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036620">
        <property type="entry name" value="MC1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05854">
        <property type="entry name" value="MC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102875">
        <property type="entry name" value="SSF102875"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MC1" evidence="3">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="102" mass="11488" checksum="2803C998F310657E" modified="2019-02-13" version="1">MVREDGKRNFALRESSGDESSVFSGNTPRQAALKAARRLDPGSSEDDADRVELELREKGTDKVHIYDGWAWEETAPDDKPDWMPSEITEANVSKKGIEHLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV82</accession>
    <name>A0A3N6LV82_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit Rpo1N</fullName>
            <ecNumber evidence="8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit A'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpo1N</name>
        <name evidence="8" type="synonym">rpoA1</name>
        <name evidence="13" type="ORF">EA462_00050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.</text>
    </comment>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 9">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds at least 2 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92667">
        <property type="protein sequence ID" value="RQG92667"/>
        <property type="gene ID" value="EA462_00050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02582">
        <property type="entry name" value="RNAP_archeal_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00863">
        <property type="entry name" value="RNApol_arch_Rpo1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012758">
        <property type="entry name" value="RPO1N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02390">
        <property type="entry name" value="RNA_pol_rpoA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 8 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="12">
        <location>
            <begin position="274"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="936"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="712"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG92667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="973" mass="109419" checksum="439A9DE02BB7E1B3" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVA3</accession>
    <name>A0A3N6LVA3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylmercury lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91604">
        <property type="protein sequence ID" value="RQG91604"/>
        <property type="gene ID" value="EA462_06535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018836">
        <property type="term" value="F:alkylmercury lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046413">
        <property type="term" value="P:organomercury catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004927">
        <property type="entry name" value="MerB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03243">
        <property type="entry name" value="MerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="237" mass="24985" checksum="9CE8499058E52ADC" modified="2019-02-13" version="1">MTPRFDGCGGNSGCGCESAGRKNGSADDAERPTPIESEPTGSGSNATEDRWVEDPTDSAATLPEDVQTAMERFLGTEPLETMVDCLPAVRRRVFGDTVDVVDLCHADGETDHRAVLEGETYHFRCFYDVILLAALTSSPVEMRTVAPDGAAVTARVTGTGKPTVSPTSAVASFGIETDVEPLSASDRPLEVSYAAICPHTNAFPSRPEYEAWAATASAATIGMPLANATELAELLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVH1</accession>
    <name>A0A3N6LVH1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92717">
        <property type="protein sequence ID" value="RQG92717"/>
        <property type="gene ID" value="EA462_00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="128" mass="14488" checksum="6FF4403CD3ACB1B5" modified="2019-02-13" version="1">MAIVPPEAKRRLETETPIAHLATCREGLPHVAPVWYRYENEVIEIVTTGTKLENIRENSRVALSIQADDAGDPDWVVTMLGTGTVIEDDERTATARRRINERYDVKPDAYDENALVRIDIGSATYRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVN1</accession>
    <name>A0A3N6LVN1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="7">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">aIF2-gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">eIF-2-gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eif2g</name>
        <name evidence="9" type="ORF">EA462_00840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92807">
        <property type="protein sequence ID" value="RQG92807"/>
        <property type="gene ID" value="EA462_00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00119">
        <property type="entry name" value="eIF_2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022424">
        <property type="entry name" value="TIF2_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03680">
        <property type="entry name" value="eif2g_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="6"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG92807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="410" mass="43573" checksum="306B316EDACECD72" modified="2019-02-13" version="1">MAGNRQPEVNIGLVGHVDHGKTTLVQALSGSWTDQHSEEMKRGISIRLGYADATFRHCPDVDEPECYTVEQECPDGSDSEPLRTVSFVDAPGHETLMATMLSGASLMDGAVLVISASEPVPQPQTEEHLMALDIIGIDNIVIAQNKVDLVSGDQARQNYEEIQEFVEGTVAEDAPVVPISAGQEVNVDLLIQAIEDEIPTPERDPDDDPRMHVARSFDINKPGTTHENLTGGVLGGSLVHGELEVDDELEIRPGREVEEGGRSEYVPIETTIRSLQAGGESADTVTPGGLLGVGTGLDPSLTKGDALAGRIAGPPGSLPPTWDQFTMGVDLLERVVGVDGGEMVDEISTGEPLMMTVGTATTVGAVTSARDGECEVDLKRPVSAEPGAKIAINRRIGARWRLIGLGTLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVQ0</accession>
    <name>A0A3N6LVQ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92837">
        <property type="protein sequence ID" value="RQG92837"/>
        <property type="gene ID" value="EA462_01010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="30549" checksum="BD981D3B495C227A" modified="2019-02-13" version="1">MITDTRLRQLARELDVRLGYAEKNYVNSWILWAIYTSSYGDNLLFKGGTALSKLYFPETWRYSEDLDLGVEGGYRGSEEELEMALDDAARRSGIDFEVTQHRELRNEGYPTHYVDIDIQYNAVLGHRNTTSLDVMIDEFVAFDSVEHTHQYEDTPEFILTAYSLEEIFAEKLRALYQRSQARDYYDLYRMITEADVDDSVIVPAFTRKCEHDGLEINLEDGLPSEKRAEIRDGWQNTLPDLVANLPEFDSVYEILEDYIESLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWM3</accession>
    <name>A0A3N6LWM3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxo acid dehydrogenase subunit E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_03490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93267">
        <property type="protein sequence ID" value="RQG93267"/>
        <property type="gene ID" value="EA462_03490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="4">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="527" mass="56623" checksum="ED56383B9F08AE5A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LX41</accession>
    <name>A0A3N6LX41_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_17050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86177">
        <property type="protein sequence ID" value="RQG86177"/>
        <property type="gene ID" value="EA462_17050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="4"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG86177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="379" mass="41293" checksum="3E09A8DDEA589ADA" modified="2019-02-13" version="1">MTELRLEGVSKRYGASGSGAADDEDDERTGERRTVALEGVDLTVRDGEFFTLVGPSGCGKTTTLRTIAGFEEPTTGVVTFDGESMAGVPPERRNIGVVFQSYALFPHMNVAENVAYGLQFQEPPAGTTSDERVSELLELVDLSGMGHRDPDQLSGGQQQRVALARALAPQPELLLLDEPMSALDARLRESLRLQLAQIQSELGITTVYVTHDQEEALAISDRLAVLNRGRVEQIGTPQQIYHEPATRFVADFVGDNNVFDGSVRHSSGDRIRVTVDGVTFELGSPVDRTADPIGPPTDRERDRVSFCVRPEALTRTADRNRFSVAVETCEFLGESVRVHGCWNEVPIVLRLSDVPDGEEVTVGFDPADARLLNATPSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXK4</accession>
    <name>A0A3N6LXK4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_16215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86801">
        <property type="protein sequence ID" value="RQG86801"/>
        <property type="gene ID" value="EA462_16215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="112"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="336" mass="36960" checksum="EA6E30982EEF1DC1" modified="2019-02-13" version="1">MFAESEFTEVTTSQRLSEVFTQSIYEPFVVAWEDWRTKVGLTIISLYLVIGTIAWVSTSEFLVLDRITIIEPARGDGPIRLAPFQDWSYPLGTDMIGRDLLAAMIHATPRMLQMILAGAVFATALATVVGTLAGYKGGLTERSLMTISDVLMTIPGLPLVIVLIVLIDPSSPYLIGIIIVVNAWAGLARTIHSQVLTIREHSYVEASRTMGVGTPTIIRKDVLPNLMPYILINFTSMARRVIYDSVALYFLGVISVQTIENWGVMMNIGYENNALVIPEVSHLLFVPMIFVVGLSFGLILFSQGTDRLFNPRVRARGSNSKKTDDDEEITTGGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY31</accession>
    <name>A0A3N6LY31_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">smc</name>
        <name evidence="6" type="ORF">EA462_00485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92744">
        <property type="protein sequence ID" value="RQG92744"/>
        <property type="gene ID" value="EA462_00485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02169">
        <property type="entry name" value="SMC_prok_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="5">
        <location>
            <begin position="542"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="917"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1190" mass="134559" checksum="3C070E6305182B8E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYA2</accession>
    <name>A0A3N6LYA2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_16260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86692">
        <property type="protein sequence ID" value="RQG86692"/>
        <property type="gene ID" value="EA462_16260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_51K" evidence="7">
        <location>
            <begin position="147"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="NADH_4Fe-4S" evidence="8">
        <location>
            <begin position="416"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG86692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="507" mass="53334" checksum="95832C37F01FFE7E" modified="2019-02-13" version="1">MTDESGTVRRSPVVRVAADVSSQRADRVCEVARDAADAVPVVRTGPTGVDAIEPLVLLTDGGRTVLFPDPAPSAVSDLVTAFESDGVPAASTDATVDHDPDATALPTPETGALSVGCRRVLGPCGWADPLEPADHALRSSERHAGTVADVGILGRGRGDAREDEPAADAWELARETDGDPVVVVNANEPDDRHRADRTLLAGAPIAVLDGVAAVAAYVGAEDAVIYLNERDEELERHLRRAVDAAADALSIVPEVVVGPDEYRAGAPTAALEVMEGADRIEPRRKPPTPAEYGLYGRPTVVHTPRTFAQVQRALRDPDSFDADAPDPGTRLVTVTGDVDAPATVELDSATELAAVREAVSMTGAFKMACVGGVFGGITADLDVVDSEPAIAAAGLGTDGVVELLNDDRCPVATAGERARFASLENSGRCVPGREGTKQLTELLRETYLGSFRSDEIRELGRVMSRSSNCRIGACAPRPVISAMNEFEPEFRVHADGRCPNGTCFENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYU8</accession>
    <name>A0A3N6LYU8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homoserine kinase</fullName>
            <shortName evidence="5">HK</shortName>
            <shortName evidence="5">HSK</shortName>
            <ecNumber evidence="5">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thrB</name>
        <name evidence="8" type="ORF">EA462_14780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86922">
        <property type="protein sequence ID" value="RQG86922"/>
        <property type="gene ID" value="EA462_14780"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="72"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="7">
        <location>
            <begin position="199"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="295" mass="29928" checksum="593084AA93825F6F" modified="2019-02-13" version="1">MLTVRAPATSANLGSGFDVFGVALGAPADVIRVERAPETSISVTGAGSQYIPEDPKKNTVGAVAEALEAPAHIRIDKGVRPSSGLGSSAASAAGAAVALNELYDRGYTREELVPIAAEGEALVSGEAHADNVAPSLLGGFTIVTDHGVNRVDASIPVVACLPETTVSTRDARGVVPDRAHMNDVVDTVGNAATLSLGMAKNDPELVGNGMNDGIVTPERAALIRGYDRVRDAALEAGATGVTVSGAGPGILSVCHARDQRAVASTMLGAFDSIGIESRAYQTSVGGGATLFTEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ80</accession>
    <name>A0A3N6LZ80_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88043">
        <property type="protein sequence ID" value="RQG88043"/>
        <property type="gene ID" value="EA462_14425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="29053" checksum="0A224AA8A2565B48" modified="2019-02-13" version="1">MIHKRSDMGYKANRRVETSIKTFEIIERLKQGDPVGVSELASEMDMSKSIVHNHLSTLRELGYITKIEDKYALSLEFFTLGTDVRSKAPLYKFGRQVAEHSSSDLAAPIIIAQKFDNETIVIYRTNGTEIHIPDLELGATAKLGRTLPGVAILRTMDKGDIDDEAVSHDHDHPELTPTTESDEYVIGNVTTTDSVSAVASPVTVQDDVIGSICVLSPQASSSAIVDQIVPEITSIRSQLESQLKYNWSTNQSFATIKHSWYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZA5</accession>
    <name>A0A3N6LZA5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrE</name>
        <name evidence="6" type="ORF">EA462_14590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88073">
        <property type="protein sequence ID" value="RQG88073"/>
        <property type="gene ID" value="EA462_14590"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="51"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="116"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="175" mass="19062" checksum="1C170EC686A6E89D" modified="2019-02-13" version="1">MSDTELGTLIEDSGAVMTGKFKLSDGSLTDYYIDKYVFETKPDILSIITDEIVDQIDEDEIDVVVGPALGAVPLVTAVSLEARIPAAYIRMGEKHRGTQARVEGTIEKGMRVAVLEDVTSTGNTILETAKLVEEIGGLVEQLITVVDRNAGAVEHIRDEGYELDFLTRVGEDFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZB3</accession>
    <name>A0A3N6LZB3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3006 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88083">
        <property type="protein sequence ID" value="RQG88083"/>
        <property type="gene ID" value="EA462_14640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021377">
        <property type="entry name" value="DUF3006"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11213">
        <property type="entry name" value="DUF3006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="91" mass="10245" checksum="78DEFB1AC51AF659" modified="2019-02-13" version="1">MTETYTATLDRIVDGQTAVLLLEENGETVEQLEADVTKLPPEAQHERAVLEIAVEASELCEAEYLPEVTQSRKESLQERLDRLSKTLSDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZX4</accession>
    <name>A0A3N6LZX4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_13050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87794">
        <property type="protein sequence ID" value="RQG87794"/>
        <property type="gene ID" value="EA462_13050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="102"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="330" mass="36835" checksum="41B6D8958A6F289C" modified="2019-02-13" version="1">MNWYLQRTIQMLLTVYVVITLTFVLTRMLPGSAIGVLRARLEDETDMSSAEVEAAIQQFINIHPDDPIHIAYRDYMLATLQGDLGQSIWYGRSVNEIVAEAIPWTLFIVSWSLFIGFFVGIILGSLMAYYEGGKIDVGLTTYGMVAGSIPYYIFAVFLLIFLSYRTGIFPTSGRVGNVEHGFNLAFMGSVIHHAALPTISMILAGSIASLSMRGNSIRVLGSDYLRVARLRGLSNNTIISQYVLRNAVLPMYTSFMIKIGQMFGGVIILEMIFGYHGMGWFMVESVDTRDYPLMMGCFMVITIAVVIALFLADLTYPKIDPRVTTENEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1X2</accession>
    <name>A0A3N6M1X2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89091">
        <property type="protein sequence ID" value="RQG89091"/>
        <property type="gene ID" value="EA462_12010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="7280" checksum="00539E4F30D74A5D" modified="2019-02-13" version="1">MVRTNTFTEKTMPNCQNCGAFVTDAYARVFTPRGIDEPRVCPECEDKIRDGADVRSARSPRNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3D1</accession>
    <name>A0A3N6M3D1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_17190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86203">
        <property type="protein sequence ID" value="RQG86203"/>
        <property type="gene ID" value="EA462_17190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="3">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="2">
        <location>
            <begin position="247"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="650" mass="73869" checksum="47ED65AA6190739F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3J3</accession>
    <name>A0A3N6M3J3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_16170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86677">
        <property type="protein sequence ID" value="RQG86677"/>
        <property type="gene ID" value="EA462_16170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="93"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="474" mass="51812" checksum="8B3396C5E6168431" modified="2019-02-13" version="1">MKRTRRNVLRDASKLSALLAGLGAAGAAKADSDEYPEWDSETVYTGDDRVVYDGSVWEASWWTQGDEPGESEWGPWEEVDDSGDPDPEPPDGPTATVSTDPLSPEPGDEVEFDAADSDGEIEDYGWEFGDGETATGENVTHAYGEEGEYTVELTVIDDGGQTDSETVTVSVEPEDESPPVDPGEIPDQVFAPYHHLTTDPETTPVEWSGPAGTDYFHLAFILGTGDGTPAWDGDVDHVVGESQFDDEIRELQDQGGQAIISFGGAVGNYLASDYDDPTELADTLEFIVDEYDCPYLDIDDEAPDMDVVDLRNEAIAILQDRRPDVHVGYTVRTRVDGVADTEIITNAIDNGVDVGYVNLMTMNWGWVRTSAENCIECAEGTHDQLQEWLPEKSDEELYTMIGITPMIGVQNSGGPFYPEDAAEVRSYAEDHDLGLLSFWSIERDNPGDGLDAEHSGIEQDPFDFSENVSPFTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4L1</accession>
    <name>A0A3N6M4L1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_09285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90171">
        <property type="protein sequence ID" value="RQG90171"/>
        <property type="gene ID" value="EA462_09285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="53"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="413" mass="43920" checksum="241482D31A26863D" modified="2019-02-13" version="1">MEHRGFDLEDRLATLEKHEQRRTLSPVDRVAERGYFAEPSGGGLPVLESEEALVFASDNYLGLTDDQRVQDAARQAAATVGTGAGSSRPVTGDTMVHHDLERLLAETKSTDRSLTFSSGYAASIGAITALEPDVVFVDERTRASLIDGCRLTDCETVAYDHRDPSSLRSEMETRAEHVEVSTDGGPRTDAGAHESWLIATDSVFEADGSVAPLSELADVAGEFGAWLLVDESDATGLYADGGGIVQADGLEERVHVQVGTFSKALASQGGYVAGSDALIECLISEARPFLSSAGLAPPSAAAASEALHLARHTDLRERLWNNVAHLRDGLKTMGFDAPGDSQILPLAVEDRSDARLLVQGLRDRGVVASLLGHSVTSGDETRVRIAPMASHDEADIVTCLEAFRTVGEDVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4X8</accession>
    <name>A0A3N6M4X8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetate--CoA ligase</fullName>
            <ecNumber evidence="8">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acs</name>
        <name evidence="8" type="ORF">EA462_10005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90301">
        <property type="protein sequence ID" value="RQG90301"/>
        <property type="gene ID" value="EA462_10005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="7">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="5">
        <location>
            <begin position="94"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="6">
        <location>
            <begin position="560"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="674" mass="74594" checksum="61CFB8AAABD1D5C5" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6E8</accession>
    <name>A0A3N6M6E8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88876">
        <property type="protein sequence ID" value="RQG88876"/>
        <property type="gene ID" value="EA462_10790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="94" mass="11160" checksum="EDBB602497C3A6C9" modified="2019-02-13" version="1">MDWDDPAHEINRGLLYEEDGRTDPDPDDQRLETFKRGWRYGVYPADEDFGELAFSKLSWQNLGYRLGVMFGETSEELQEELYDWCVRQMRESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6V8</accession>
    <name>A0A3N6M6V8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89066">
        <property type="protein sequence ID" value="RQG89066"/>
        <property type="gene ID" value="EA462_11855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="12465" checksum="202C80C4F8219DB2" modified="2019-02-13" version="1">MIPRPTKGGSIVVLLLAGTVLGAGVLATRYPELRSAMTIVVGAAITFALLAPYVVPGVYDRPTTSIIGVLVASVGGYGILLDDTASVLMWLLLVGGIAMVAEDQYRRRRGSGSPEGHEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M771</accession>
    <name>A0A3N6M771_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89196">
        <property type="protein sequence ID" value="RQG89196"/>
        <property type="gene ID" value="EA462_12585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="454" mass="48653" checksum="5F821E923869A380" modified="2019-02-13" version="1">MTAGPPIAELHYEDAPNVDSVPGPNTRALLEKQREIDSSAVAYPEDIPIAFDEGKGATVRDADGNTFIDMFAGIGVLNVGHANPYVLEAVHEQADKFVHSVDFPTEARLELIEKLDEIAPDGLAGENRVVFGGPTGSDAIEASIKLAKYNTGGTGLVAFRGGYHGPTSGAMSLTSNKSFKEHYTPLLPDVVHAPYPHPFRQDKSPADAVDHALEEVQAILEDPYGGLANPAGIVVEPIQGEGGIVTPPEGFLQGLRDIADDNDVPLVFDEIQSGLGRTGEWWAADWAGVTPDIMTSAKALGGIGFPLSATIYHEDLDTWGPGDHAGTYRGHVVGMRAGTRAIEYIQEHDLLAHARDLGEYIRRRLREAPTDRLGDVRGTGLFIGAEFVDEDGEPGGDFVDAVQQYCFEHGVLVWTAGRHGNVLRFLPPLVLTHDLAETALDVVLEAIEHADGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7W8</accession>
    <name>A0A3N6M7W8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF106 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_05595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91441">
        <property type="protein sequence ID" value="RQG91441"/>
        <property type="gene ID" value="EA462_05595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038978">
        <property type="entry name" value="MJ0935"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42198">
        <property type="entry name" value="PTHR42198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="315" mass="35618" checksum="7671909309DECBDC" modified="2019-02-13" version="1">MTRTAEKITALVREDSSMVDALEAIRETADENGGEVQWQDVSDDLTSGQWGRLIEKGVLVDGNEGFEIADRDAYDGALDGDGDGESVVEEVDIDDEQSKWSQWDKLAAVGSVLLMIGYWLESVRDTVGGTLDLALAPLDATLPFYAVILSVAMLTGLYSTLLQANLMNPEVMGKYQQRMKSMQEKQKDVRNRKKEAEERDASEAEIERLENELEAVREEQMEAMADNIGMFKEQFRPMVWIMLFTIPLFLWMYWKIIDGHVSQAEMTMIMPIAGEVSLNQGLIGPMWAWIVWYFLCSMGFTQLLRKALNIDMTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8I6</accession>
    <name>A0A3N6M8I6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91681">
        <property type="protein sequence ID" value="RQG91681"/>
        <property type="gene ID" value="EA462_03545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="6484" checksum="2A37D8CD63E45201" modified="2019-02-13" version="1">MSVSGLCQICESRPAQERCSNCGTLACEKHYERGTGLCADCVARADPERGHDDVDVHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8R1</accession>
    <name>A0A3N6M8R1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89856">
        <property type="protein sequence ID" value="RQG89856"/>
        <property type="gene ID" value="EA462_07525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="299" mass="33100" checksum="7A54F7A1F5A40E68" modified="2019-02-13" version="1">MSDGSFVDEGFDELLEDATRSLETIEERLGGLESLDELDDDERQSILGDVETLTTVAIEAEELLETVDFGELPEAVDGDDLVEAIELGELPEVLGDEDSGPGDVVDFERAFRAIDLLSAWDATDLADLWEEKRELEGAVDDVAADDEDANVLEETVSAVTDESDDLLEGNDDLLGDAEPTDILGDIDVMEDPQAYQIAIQQAAIEGIDAFREGLLEAHETFERLYERNRETMRRQDASANSRNPTAASTVPVERRDLGGGARHATVPQQVRLSTAPSRTRIYGRRFELEREKRRNDDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M903</accession>
    <name>A0A3N6M903_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89966">
        <property type="protein sequence ID" value="RQG89966"/>
        <property type="gene ID" value="EA462_08135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="273" mass="28426" checksum="8F56AB1EDFAF24D9" modified="2019-02-13" version="1">MVRPSPSSIALGAVGGGVNVALVLALYARAGYPTLETYAGVSLLVVTGFVLGFVPAFVSAHTRLIVPAIGFLAALAGTVFVELTTPSPEWSELEGYLVVDGPTHVGSYANTWYVWLSLFLLAGVLECGIRQGYGIETRRLRNLPTPPFSPGTLAWVVLGFASLVGVSTVLLALRAGIRPPIAAVGVFVGAVGVTAVPLAAVLARGIVSPAILFAVLVPYVLSVEVFTTTDSPVHLLLFGPYAVVLVVAWVLEATVRSRVRGWDGGRFVSDGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M922</accession>
    <name>A0A3N6M922_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92760">
        <property type="protein sequence ID" value="RQG92760"/>
        <property type="gene ID" value="EA462_00570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="28116" checksum="532B2033551A0C21" modified="2019-02-13" version="1">MTLRSHIEDVGSVDHALAVIDTDVADPLTALLAETFDWEGIEVETEVTDGESSYLEGETDAVALLEDGALVATSTMTELYESILAINSDLFVTGSRTFGEIDVPDVLEGLDDSRLRLRGYPLADKEKLVLILVSRYIEQLAWSSRSGTLRSSFQHLSRLNDEVGTNEVYARLEETNVDVHVYGFRGSTDLDVTAHLGSTTEHRDGWFVIYDPDDPSSDDAAALVCLEVEPRVWDGFFTFDAARTAALEEYIAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M942</accession>
    <name>A0A3N6M942_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.65</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90006">
        <property type="protein sequence ID" value="RQG90006"/>
        <property type="gene ID" value="EA462_08345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="213" mass="23147" checksum="8FD0F0FEB919B679" modified="2019-02-13" version="1">MKFAPDAWKYAIVPLLAAPFAFIFSTTLSILALATGIGTLAFFRDPDRTPPLTGVVTPADGTVSVLRQEGDRVRLGVFMNVWHVHVVRAPVDATVSAVEHVPGANRPAFSKESDRNERVRIRLETTDGRFEGETPLDAEITLIAGAFARRIHPYVEPGDELERGDRIGHIAFGSRVDVLFPPSVDREEITVSVGDSMTAGETVVLESNGPTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M992</accession>
    <name>A0A3N6M992_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_08740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90076">
        <property type="protein sequence ID" value="RQG90076"/>
        <property type="gene ID" value="EA462_08740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="70"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="252" mass="28124" checksum="2F9A6D1E64BA1191" modified="2019-02-13" version="1">MSATDGGDTRKTTKTSLAVVEAINELDGATLSELADHTGLATSTLHTHLRTLEETEYVTRIDNTYQLGLKLFYLGENARRRDSRYTLAKEKAFRLANQVSEEVNFAVEEYGRSIMLFDETPSPSDTGFQVGRYFHMHSSASGKAMLAEYSEQRVDEIIDKWGLPKYTENTITDIDELRGELETIREQGYAVNQQEELEGLHSVAMVINNPDGSVFGSLDVSGPPYRLPEDHEIAAQLQPVVEELESELEDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC47</accession>
    <name>A0A3N6MC47_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91266">
        <property type="protein sequence ID" value="RQG91266"/>
        <property type="gene ID" value="EA462_04555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="172"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="336" mass="38336" checksum="68B8044E7AE8F969" modified="2019-02-13" version="1">MSIEIDVFNPRTDGDEWNRYVERSAGANPFFRAEALRLQAEETGTRPHLLVGFKGQEAVGIFPVFEFHKGPLTGAFSPAPRSWSCYLGPSVLNLEKLKQRKADRRIKRFLEGSLEWIDENISPQYCKFVAAEFDDVRPFVWKEYDVTPGYTYIIDLEGSANELLERFSSDARSNVRNADDGSYVIEEGTGDDVERIIEQVSNRYESQGRAFHLRPEFVRSVHSTLPDGAIRPYVCRGGGDFLGGILVVESETTRYRWQGGVKPDIDVDLPINDLLDWHVMRDGLERGLERYDLVGAGVPSINRYKAKFNPRLETHYEITSGAFGLDLVIDRYRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCC2</accession>
    <name>A0A3N6MCC2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome C oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_05160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91366">
        <property type="protein sequence ID" value="RQG91366"/>
        <property type="gene ID" value="EA462_05160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="761"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="8">
        <location>
            <begin position="7"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="7">
        <location>
            <begin position="550"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="824" mass="92064" checksum="3FD27DDFF8F99ADE" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCD1</accession>
    <name>A0A3N6MCD1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_05215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91376">
        <property type="protein sequence ID" value="RQG91376"/>
        <property type="gene ID" value="EA462_05215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="4">
        <location>
            <begin position="257"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="377" mass="39752" checksum="9B0550CD109D80CF" modified="2019-02-13" version="1">MSQTPVVVEAVRTPQGKEGGVFADLRSEELSIPLVDELLDRTGLTGEDIDDLMWGCAQQRDEQGNNVARVIALLSELGESVPATTINRWCASSMQAVMSASDAIAAGNRDVIIAGGVENMSRIAMGENTPNVHPGMAERYNIGELQMGMTAETVAEEYDISREKQDEYAAKSQQRAVEATEDGRFDDETVPIETDDGVVDEDEGLRPGTTASKLAELPSVFKADGTVTPGNASQISDGAAALLVTSESFANDHDLEIVAHVGMNNVAGVDPTVMGIGPVPATRGLLERNGRDIDDYDLVELNEAFASQAVYSRDELGVDPDLFNVNGGAIAIGHPLGASGARLPVTLIHELQKRGGGLGLATLCVGFGQGAAIEFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCR6</accession>
    <name>A0A3N6MCR6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Potassium transporter Kef</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_06195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91546">
        <property type="protein sequence ID" value="RQG91546"/>
        <property type="gene ID" value="EA462_06195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="12"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="7">
        <location>
            <begin position="413"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="586" mass="64956" checksum="776518BEBCB21B9E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MG18</accession>
    <name>A0A3N6MG18_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92866">
        <property type="protein sequence ID" value="RQG92866"/>
        <property type="gene ID" value="EA462_01180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038767">
        <property type="entry name" value="Transcriptional_reg_pdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40663">
        <property type="entry name" value="PTHR40663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="96" mass="10534" checksum="3A4834690AFA1566" modified="2019-02-13" version="1">MREADETTRQRLADALRSEPATPSELAADFELTSGAVIDHVHHVARSIDAGDDRFLVAPPTCRDCGFDDFDDLLNRPSRCPSCKSESIAEPTFAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGN1</accession>
    <name>A0A3N6MGN1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006087767.1">
        <property type="nucleotide sequence ID" value="NZ_REFY01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93126">
        <property type="protein sequence ID" value="RQG93126"/>
        <property type="gene ID" value="EA462_02675"/>
    </dbReference>
    <dbReference type="GeneID" id="39851265"/>
    <dbReference type="GeneID" id="56035259"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="7002" checksum="4F3BF2DF7DFDCAA3" modified="2019-02-13" version="1">MAKGNVDFFNDTGGYGFISTDDADDDVFFHMEDVGGPDLEEGTDIEFDIEQAPKGPRATNVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MS62</accession>
    <name>A0A3N6MS62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_15635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87063">
        <property type="protein sequence ID" value="RQG87063"/>
        <property type="gene ID" value="EA462_15635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="101"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="193" mass="21529" checksum="291ECCBF1CF3F606" modified="2019-02-13" version="1">MTPQQSIPDADESIDDQSAETDGSDPSRHERVRLRTRPTIKPPLVWILVTVIVGGALALASFANVYGLEDPGLASIVGWTVVFVVFVVSLRLLVRIYVLTRTTYTVTETDIRHEFSLWFRQYSREIPLDRVRGQEFQQDRIQRVFGVGTISVLTGGTNASLGYVEFQNVPNPNEVTETVREQRLAASPIGGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MU67</accession>
    <name>A0A3N6MU67_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88932">
        <property type="protein sequence ID" value="RQG88932"/>
        <property type="gene ID" value="EA462_11095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="266" mass="28158" checksum="4D24A2947BBF19EF" modified="2019-02-13" version="1">MITIATDFGTPYPAAMKGVLLQRTDARLVDVAHDFPRQDVRAAAFWLREVLPYFPPATHLVVVDPGVGTDRDTLVLRADEHVLVGPDNGVLVPPARRLAGTTELEAYGIDERAVSHDGRSGPASNTFHGRDVFAPAAAAVHGTSRDSLESVAALEATTSYVDLELPSAAVESDESRAAGDVLAIDDFGNVVTNVPGDFLEGRSRLVANGEVVPVGETFASVSIGTRLATVGSHGYVELDVNQGRGDDAFGLDTGDRVILEGDEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUQ6</accession>
    <name>A0A3N6MUQ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Site-2 protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_12225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89132">
        <property type="protein sequence ID" value="RQG89132"/>
        <property type="gene ID" value="EA462_12225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="PTHR31412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="7">
        <location>
            <begin position="143"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="7">
        <location>
            <begin position="270"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="393" mass="42248" checksum="95CE3CD7171D3A46" modified="2019-02-13" version="1">MDDVDSSGYSTSTRAQPLQNGPPLERIESVFSVYETQTEGETAGSDEASRTLVYYGDPLVPPQDVMSELWPVFQEAGYEPELTTRHGEFVLVAEPKQVGVDGVPWTNVVLLCLTVASTLFAGSMWYHIDPIANPTEMWRAWPFTVAILGVLGVHEMGHYVTSRYHDVDASLPYFIPVPTLIGTMGAVIKMKGRMPDRKALFDIGVAGPLAGLVATIAVTVVGLHLPPVTAPESVVQDPNAIQIRLGYPPLLEMLAAAFDQPLYRDDPATAVNPVVIGGWVGMFVTFLNLIPVGQLDGGHILRAMAGEFQETIAALVPGALFGLAVYLYYVGDHGGNSVLIWAVWGVFTAILATVGPAHPVRDDRLGLGRLLLGIVTFGLGILCFMAVPIAIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MV47</accession>
    <name>A0A3N6MV47_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_12310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89292">
        <property type="protein sequence ID" value="RQG89292"/>
        <property type="gene ID" value="EA462_12310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="553" mass="57948" checksum="CE7EA2CF087D91BE" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWG1</accession>
    <name>A0A3N6MWG1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89822">
        <property type="protein sequence ID" value="RQG89822"/>
        <property type="gene ID" value="EA462_07330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="99" mass="11183" checksum="78D5658396E01C7E" modified="2019-02-13" version="1">MATKQQMTERDVPTERAEELGQQAMGPAFLASAASVGLSWYYFFLRGDRERGLFIGLWPPTILAFASYFNQRKMRQQLDTITKPGTSIKNAIDSMMGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWV5</accession>
    <name>A0A3N6MWV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89972">
        <property type="protein sequence ID" value="RQG89972"/>
        <property type="gene ID" value="EA462_08170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="313"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="468" mass="53028" checksum="7D19D9D7652F7932" modified="2019-02-13" version="1">MPAFVNREQELDRLHELYGSDSAELSVVYGRRRMGKTALVVKSIENRDDAVYHQAAHGTTEQQLDSFIADAATVFPGVNRIRKDWENVLTYLAEQDAIVILDEFPYLVDENEALPSLIQRLWDHNVEETAASFVLTGSAIGMIHKIALDGSSPLYGRISKRPNGKLEIGPLPFAAAMEFFPNYAPAEQVIAYGVFGGTPEYLRAVDDAQSLQGNITETLLLRDGGLHEEPEDVLYRELDEVDRYFAVLKAMAEGNHKRNEIIQAAGINANSASYYLSRLRELQIIEQEYPVTVDPSRSRNSRYRIRDQLFAFWFRFVHGRSSRYEVFGADAYDELVEPHLPDFVSTTFECLCQRAVLYEYGDVYRFTEVPDRWWDTDGREIDMVAPTNDGTLLVGEAKFQQQPMGYDVLAQLEQEAPEVEWSPTDGDVNYEYALFSRSGFASSLEEAAEKRDDLGLFTVDDVVETLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0J2</accession>
    <name>A0A3N6N0J2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91422">
        <property type="protein sequence ID" value="RQG91422"/>
        <property type="gene ID" value="EA462_05475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="310" mass="32947" checksum="13E249884065A12D" modified="2019-02-13" version="1">MSWRCLSDLPRSLLAIGPIVVLGAIFGVLYLTSPFGDLGSVDDASTLEIIWMLTVIGALAGVVPVAIGMLWFPFIRDLDPRYLHAFLALAAGVLVFIALEMSEDVLEYSVDAENTLLAGSLAVIGVVGTFVVMYVASKWRQRKVTATDKSGLEIAYLVALALGLHSIGEGLGIGVAYIQGDSTLVMLLVLAFVLHNVMEGPTVVAAVARDRETPPLYHFAAMGLIAGGPVILGGWIGSFAQSDLLAVLFFSIAVGAIVQVLIEVAELIRFDAEAVLTRVNAATFVVGFALMFFLEDVLGDLLLEGWLVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0N1</accession>
    <name>A0A3N6N0N1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91462">
        <property type="protein sequence ID" value="RQG91462"/>
        <property type="gene ID" value="EA462_05730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="17"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="429" mass="44720" checksum="2F32F72E17A52A1E" modified="2019-02-13" version="1">MRELARRIVAQFVVDRRVLALAFARMADGVGNSFLIIVIPLYVASDVVGGTTLGLEEAMIIGIILSLFGFLNSSFQPFTGRLSDRIGRRKPFILIGLGGLAATNLAYVFAESYLSLVFIRSLQGISVAFIVPASIALVNELATTHDRGGNMGVYNTFRLVGFGAGPVAAGAVVNLGPYGLPGGTIISGFDAAFYVAAITALLSYAMVTVLISDPDSTKANAGADLSISIRDRTGPNVLDPIFTLGVASLLMAAAIALFATIQPQVNGRLEQGSTWFGLQFAAFIIAQILLQTPIGRACDVFGRRPFIVGGMILLIPTTLVQGFVPSSEAMFLARLLQGIAGAMVFAPSLALAGDLAGEGESGSKLSVLTMAFGFGIAVGPLSSGALIGYGFYVPFVFGTVLAVFGSILVYTQIEETLETRTALPIVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4B1</accession>
    <name>A0A3N6N4B1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I-D CRISPR-associated protein Cas10d/Csc3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cas10d</name>
        <name evidence="2" type="ORF">EA462_02025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93012">
        <property type="protein sequence ID" value="RQG93012"/>
        <property type="gene ID" value="EA462_02025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017589">
        <property type="entry name" value="CRISPR-assoc_prot_Csc3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03174">
        <property type="entry name" value="cas_Csc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115386" checksum="5EF21869B6B42614" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVG1</accession>
    <name>A0A3N6NVG1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_13140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87812">
        <property type="protein sequence ID" value="RQG87812"/>
        <property type="gene ID" value="EA462_13140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="73"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="257" mass="28166" checksum="C9527A7E0BFA4418" modified="2019-02-13" version="1">MGSQADGAGKRRVKALEKGLRIVEELKEQGSAGVSELASELNMPTSTVHVYLQTLKGTGYVVGNDGTYQLSLRFLEIGSKVRDQREVFAAARQEMIDICHSTGETVGLGVLEDGKRVQLWQIEGKNAINDNIHIGEYTHTHWTSLGKTLLASQSDESIEEIVERHGLPRATENTITDKHALFDEVETIRAQGYTLEDEERKMGIRSVSVPLTDSDGNTIAALGITAPKNKMTSATCGNYIAQLNDKANVISIKYAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVY1</accession>
    <name>A0A3N6NVY1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88072">
        <property type="protein sequence ID" value="RQG88072"/>
        <property type="gene ID" value="EA462_14585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="444" mass="48374" checksum="9AB4A4AC0CB4426E" modified="2019-02-13" version="1">MQQDDVKQAAASRNTVPHWFNPDHPHLDIRDGDGAYVTDADGNRYLDGVSQLFCVNAGFDNQTIIDAMVEQLHKAPYVTPSQYNDTRQQLSEAMLEKAPDSMGEVYFAVSGSEANEAAVHFAREYTGSHKILTRWRSYHGWNYGTSSLTGNGWSSSVIERNAATTGAQQFLPPMSYRSPFDADTPEELAEKAADHVEFVIRNEGPDSVAAILMEPIAGASGAYTAPPGYFERLRELCDTYDILLIADEVITGFGRCGEWFGIQTENVEPDMITCAKGLTSAYAPLAGVMVSSEISEYLRDDGVPLGQTFGGHPVGCAAGLAAISEYENGLLENVRSVSPYLEERLRELEDAHDVVGNVRGRGFLWSLAFSKPGTEEPVVDPRTENTDNPVEAVADHAATDGDLLVWPGRPQTQIMVAPPFCLTRADVDQIHTALDGAIESVFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX78</accession>
    <name>A0A3N6NX78_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89259">
        <property type="protein sequence ID" value="RQG89259"/>
        <property type="gene ID" value="EA462_12915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="87" mass="9886" checksum="1354DA23D7EE9012" modified="2019-02-13" version="1">MSDSNAREHLDTKHERNREQRIEGIKRWVEYIESEPPDTWGPQQNAVVNDQLDAAQSVQTSASHQQHVKDVAAEILEVSDESDTDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX83</accession>
    <name>A0A3N6NX83_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="11" type="ORF">EA462_10920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89269">
        <property type="protein sequence ID" value="RQG89269"/>
        <property type="gene ID" value="EA462_10920"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="301"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG89269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="384" mass="41535" checksum="AB96642DD5F1037C" modified="2019-02-13" version="1">MNGNRFGRLFQVTTFGESHGKAMGCTVSGCPAGLELSEEDIQTDLDRRKPGQSMISTSRGEPDDVTINSGIQDGYTTGTPIGMVIQNKDARSGKYEPFITAPRPSHGDFTYSAKFGTRNWGGGGRSSARETVNWVAAGAIAKKLLSLEGIELKAHVNQIGDVESPEVSFEEMLEHAEENDVRCAHPETAAAMQERIETYQNEGDSIGGSVYFEARGVPAGLGAPRFDSLSARLGQAMMAVPAATAFEFGLGREAREWTGKERNDDWEFSEDGDPTPVENDHGGIQGGISSGEPIYGELTLHAPTSIPKEQQTADWETGELIEDAQVIGRHDPVLPPRGVPVVEAMLALTLVDFVLLSGRLNPDRVDDQPGNYDTDYHPSNPRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYV5</accession>
    <name>A0A3N6NYV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain-containing sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_16040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86656">
        <property type="protein sequence ID" value="RQG86656"/>
        <property type="gene ID" value="EA462_16040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="154"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="358" mass="38558" checksum="9378E78E7C768AD1" modified="2019-02-13" version="1">MPSGFGGPPIVSSRPALDSRPVKRGSRPELDIEQITRTLPSPSAICDDSTAITSVNDEFCVAVERDPEELRGMSFDDLVAEPSLEALVEGPEATSEPLSNTIEYTTPSGTRRYASATARTIEAKSESGVYTLVILHDITDLKKRSERLAEFASVVSHDLRNPLQIATGHTQLLDDEYSHSSIDEIKRVLSQVETRVTDFLAIAQYGGSVREETAVSLTTSVRNAWTTATVPTESSVSLEVDSSLDGVSVMADRERLEVLFENLFRNAIEHGGDDVTVTVETHHEGVSVIDDGCGIEPSIRGSLFDVGETTASGNTGLGLHIVSEIVDAHGWQIDVTDGTDGGARFEITGLELSVVRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ39</accession>
    <name>A0A3N6NZ39_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">thiE</name>
        <name evidence="12" type="ORF">EA462_09225</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8 10">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90159">
        <property type="protein sequence ID" value="RQG90159"/>
        <property type="gene ID" value="EA462_09225"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="11">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG90159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="221" mass="22541" checksum="D06B25A0041E0CE8" modified="2019-02-13" version="1">MNFPNWRTYLVTQASVSAGRPTDEIVSEAIDGGIDAVQLREKGTEAVSRYELGLEVRERTAEAGVDLIVNDRIDIAAAIDADGVHVGQSDLPVAVARELLGPDAIVGCSAATVEEAGQAEADGADYLGIGTIYGTASKEVEEYKDGVGPDRVAAIADAVSIPVVGIGGVTAENAAPIVEAGAVGVAVISEITAADEPRAATEALARAVETAKDPEGDGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ48</accession>
    <name>A0A3N6NZ48_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90169">
        <property type="protein sequence ID" value="RQG90169"/>
        <property type="gene ID" value="EA462_09275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="124" mass="13994" checksum="4CAC0A811E6AF3C2" modified="2019-02-13" version="1">MYAETDFLLALIKDDDWLGEAAESAYREHRDELWTSQFTLVELLMVAYREDRDTERVVTNAATLVEVRGDVETVVSAATYVEDHGFTPFDALHLVESDGDTIVSSDGTYDDVTPRLDLKTVTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZQ0</accession>
    <name>A0A3N6NZQ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoate--protein ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87056">
        <property type="protein sequence ID" value="RQG87056"/>
        <property type="gene ID" value="EA462_15585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="35"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="280" mass="31279" checksum="7EDE2B2F26C2B185" modified="2019-02-13" version="1">MTDLADERWRLIRDDPREGETQMALEEIAAETALEDDVRTVRVYSWEPSTLSLGYRQDAETVDWKYCEHEEIGVTRRQTGGGGIYHDRHADISYSIVAPASEVPGDLMECYALFCEPILSALERMGIEADFANAEQPSIYQPSCYLRDINPAHDIVAPASAGTDAGKLSGNAQYRRRDVVIQHGSLNYDRAPERHVGVFEGDLEPTTFSDRVTSVRDEVGIDRNEAVETLADTLGEWCDASEGSWRDGELEAARELAGRKYGEDAWVRDRTVLEADGENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P072</accession>
    <name>A0A3N6P072_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_13070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87798">
        <property type="protein sequence ID" value="RQG87798"/>
        <property type="gene ID" value="EA462_13070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="374"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="414"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="721" mass="80150" checksum="58D0E85BB1B273C9" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P166</accession>
    <name>A0A3N6P166_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">S-adenosylmethionine synthase</fullName>
            <shortName evidence="14">AdoMet synthase</shortName>
            <ecNumber evidence="6 14">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mat</name>
        <name evidence="16" type="ORF">EA462_04355</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the AdoMet synthase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="6 14"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91229">
        <property type="protein sequence ID" value="RQG91229"/>
        <property type="gene ID" value="EA462_04355"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00136">
        <property type="entry name" value="S_AdoMet_synth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027790">
        <property type="entry name" value="AdoMet_synthase_2_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042544">
        <property type="entry name" value="AdoMet_synthase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002795">
        <property type="entry name" value="S-AdoMet_synthetase_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36697">
        <property type="entry name" value="PTHR36697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01941">
        <property type="entry name" value="AdoMet_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 16" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RQG91229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="401" mass="43404" checksum="59124095A3EAE647" modified="2019-02-13" version="1">MSERNIRVEPIDRQAVEDQEVEIVERKGIGHPDSICDGVAESVAGALARAYLERVGEVLHFNTDETQLVAGEAAPAFGGGEVVDPIYLLIVGRATKHYDGQTIPTETIALRAAREYIEETIPQLEYGEEIVVDVKLGEGSGDLQDVFGEDEVRVPMANDTSFGVGHAPLTETERIVHEAERRLNGEFAADNPYLGPDVKLMGKREGDKIDVTVAAAMIDEHIDDLDAYADAVETVREFVAAVANEHTDRAVDVHVNTADDYESGSIYLTVTGTSAEQGDDGSVGRGNRSNGLITPNRSMSMEATSGKNPVNHIGKIYNLLSTEIAENVVEEVPGIRDLRVRLLSQIGRPIDQPHVADVHVVTADGVSLSDVDDEVEAIVDRELADVTGITRRVIDGELSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1R0</accession>
    <name>A0A3N6P1R0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_05770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91469">
        <property type="protein sequence ID" value="RQG91469"/>
        <property type="gene ID" value="EA462_05770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="347"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="556" mass="59055" checksum="CD2E13CE59C36BBC" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1U8</accession>
    <name>A0A3N6P1U8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hepar_II_III_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91519">
        <property type="protein sequence ID" value="RQG91519"/>
        <property type="gene ID" value="EA462_06035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031680">
        <property type="entry name" value="Hepar_II_III_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16889">
        <property type="entry name" value="Hepar_II_III_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hepar_II_III_N" evidence="1">
        <location>
            <begin position="152"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="585" mass="66335" checksum="0B97647C59CAC26C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P222</accession>
    <name>A0A3N6P222_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91609">
        <property type="protein sequence ID" value="RQG91609"/>
        <property type="gene ID" value="EA462_06570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="39"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="186" mass="20069" checksum="9F2655694EEF7F33" modified="2019-02-13" version="1">MDPSLEPLTRSLREAPIVDRNGYEYFVHGVTDGILSVEPDVLRAVADAIIDRVDLESVDRLVVPEAMGIHHGTALSLATDIPFVVVRKRSYGFPAEVAIHQETSYGEDELFVNGVDADDRVVIVDDVLSSGGTVDAVCAGLETIGAEIVDVVTVLRRVDVDRAADSRDVTSVLDVRIDDGEVVIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4B8</accession>
    <name>A0A3N6P4B8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90215">
        <property type="protein sequence ID" value="RQG90215"/>
        <property type="gene ID" value="EA462_09520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="392" mass="41625" checksum="E9AA548DC16D05DB" modified="2019-02-13" version="1">MSDRTAVVLAAGEGKRLRPLTRHRPKPMLPAGVRPILEYVFDALIDAGITSIVVVVGYKRTDVQSHFGPSYRDVPLTYAVQEKQLGTGHAVLPAEPHVDGSFLLVNGDQVIDNRIVRDVLERHAASRAVTTIGLLRRSDIGEYGGVLTDNGTISEIVEAPRDDREYRLNSGVYAFDQTVFDAIRRATPRAGEHLIVDAIEGQIESGDSVVGVESDGFWADATYPWDLLEVADLIVETDSRVDDVDLTSTRVHESAALRPPIVAAPGCEIGAGAVVGPDVCLGANTTVGSNAVVERCVVDADVRVGQGATLLDCVIGRGVHIGAGTVVPGGPGDVRIGDRIFEDRRLGALFGDRVEDRGATRYAPGSIVGSDAVVRTGSIVSGRNTGRTEVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P534</accession>
    <name>A0A3N6P534_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF424 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93159">
        <property type="protein sequence ID" value="RQG93159"/>
        <property type="gene ID" value="EA462_02855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007355">
        <property type="entry name" value="DUF424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04242">
        <property type="entry name" value="DUF424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="97" mass="10683" checksum="D95BE94362FF9989" modified="2019-02-13" version="1">MIVHERETPEGLLVAICDDDVLGETFEEDDLSLTVTEEFYGGDETDERGVIDSLSRATVANIVGTQAVELAIEEGFIDEANVLEVDGTHHAQLLRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P576</accession>
    <name>A0A3N6P576_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S26 family signal peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_03225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93219">
        <property type="protein sequence ID" value="RQG93219"/>
        <property type="gene ID" value="EA462_03225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="340" mass="35041" checksum="931B59C0739D1C05" modified="2019-02-13" version="1">MSGPHSDDSRSSGSDSDESDPDDTVAGESGSERPGSSRTDDERTGSGTVDTDSARAATDESDEPDVTIEDDGLLRWFVRTDDGTVVLVRDVLSSVALVAVIGLLLFGISGIWPPLVAVESGSMEPNMQRGDLIFVVADDRFVGDGATEGTGVVTLENGQNAGHEKFGQSGDVIIFKPDGSDYHTPIIHRAHFWVEDGENWVETKADEDIIGGSTCEEVPTCPAERDGFVTKGDDNSGYDQYGGARTDVVQPDWITGKAMVRVPWLGHVRLVFDSLLGGLVAPIPTAPGIGSPTGAIGTGLEAGGVGLAGATGNVGTAGTIGFIGGSIGVGGIGVAAGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P5A3</accession>
    <name>A0A3N6P5A3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93259">
        <property type="protein sequence ID" value="RQG93259"/>
        <property type="gene ID" value="EA462_03445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="88" mass="10519" checksum="2D610BA54F854B97" modified="2019-02-13" version="1">MEMFLQSPVLVNGFPYLSDQFFRRRSRISRDMRCELQNKLFELLGFCQKRCDTLRALVQHDALVCYTPMVVYHWLGGVIVRPQKIFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P650</accession>
    <name>A0A3N6P650_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II toxin-antitoxin system HicA family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91205">
        <property type="protein sequence ID" value="RQG91205"/>
        <property type="gene ID" value="EA462_04235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="83" mass="9639" checksum="A1AE3AF8B54201C3" modified="2019-02-13" version="1">MVRTSFSGREIAKVLQNHGFRRSGRTGSHLKLRYEHPETDEVRIVTVPMKSEDDIPTGTMRSIAEQCGADDFYEWCRWIDEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6C7</accession>
    <name>A0A3N6P6C7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_04785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91305">
        <property type="protein sequence ID" value="RQG91305"/>
        <property type="gene ID" value="EA462_04785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="Lhr_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="65"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="314"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="945" mass="106017" checksum="1909701CA83B715A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA93</accession>
    <name>A0A3N6PA93_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonylcarbamoyl-AMP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93275">
        <property type="protein sequence ID" value="RQG93275"/>
        <property type="gene ID" value="EA462_00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="197" mass="21441" checksum="1DD4138C3AF90B31" modified="2019-02-13" version="1">MDSDVLERAATVIHDGELVVYPTETVYGLGADALTPAAVERVFSIKGRDRSKPISLAVPRFDVALEEGYVRATDRERRFAAEFLPGPVTLLCERRARVPGVLTADRDRVGVRVPDCNRALSLLERLDTPITSTSANVSGEPSARRVEDIDESVRNAAVVLDGGQTPGTESTVVDLSTETIHRRGSKADRIDAWLTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHJ9</accession>
    <name>A0A3N6LHJ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86200">
        <property type="protein sequence ID" value="RQG86200"/>
        <property type="gene ID" value="EA462_17175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045672">
        <property type="entry name" value="MC_hydratase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19315">
        <property type="entry name" value="MC_hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="42174" checksum="33A7AF521A22D304" modified="2019-02-13" version="1">MTERPDWTDADAFARALERADTRTKGHYFEDFTDGDILEHDPGLTLTRWGNERWMSQTLNHDPAYWRSDAAAERGYDEPPIHPDYLVAATLGVTVEDLSEKGGYFLGRTNGRFPTGPVFPGTELRVESVVRETASSSSRSEYGIVTWRTRGRDADTGAVICSYERTNMIPRREPLETDGGASETGDSDGAETAGDGDGSESEPASAGGGELPETFITPDGGFFEDFVAALEDADDRNAAVAYRHERGRTQDDVTVSSLPLSTLNTAKQHHNADVMADSPSGEIVTYGDVTRSIALGHARSDERTWRELGFDDERFHTFVAPGDTVYAFTRVIETDDGRQVSNESASYSSDDAGTVRFEHIAFNQREEPVYSGTRTAAIQRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI53</accession>
    <name>A0A3N6LI53_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class I SAM-dependent methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_15010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86964">
        <property type="protein sequence ID" value="RQG86964"/>
        <property type="gene ID" value="EA462_15010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040601">
        <property type="entry name" value="Trm5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18093">
        <property type="entry name" value="Trm5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="3">
        <location>
            <begin position="79"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="329" mass="36959" checksum="63FBEECF299D82A2" modified="2019-02-13" version="1">MDVPFVRVARECGERARRELADADLIDDDYEIDVEDERLYVPVVDPDAVGDDLEVVFRAGNERDTQTTPADLLGFDPSYERLGRAVLLDEDDKERARTIADAVLESDLPVDTIVNKASKVKGETRIRDWDVLAGDDTEVVHREYGREFALDLATVYFSPRLATERHRVTEQVEADERAFDMFAGVGPFVIPVAGRGAECVGVDVNADAIEYLRDNARRNDVDDRVTAVCDDVRQVAAEYDGWADRIVMNLPHSADEFLDAAVTIAGDDCVIHYYDIQHEDDPFGPGERAIRAAAEPTYDVRVENRRTVRSYAPHELNVCLDVRLERVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI65</accession>
    <name>A0A3N6LI65_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86799">
        <property type="protein sequence ID" value="RQG86799"/>
        <property type="gene ID" value="EA462_16015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="213"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="413" mass="44474" checksum="8F96003AE4567560" modified="2019-02-13" version="1">MAVDRDRLRVDIKENAQFGAVESDSGCGRSVLTGSDADQRARKRFITRLEDAGLEPRVDPVGNIAGRWIPDGVSADTAPIALGSHLDSVPRGGIFDGPLGVYAALEAVRAIQESAETPSRPLEVVSFTEEEGSRFGVGTLGSLVAVGEISVEEALSMTNDDGDTFEECLERIGFAGSSEIDPATWDAWLEVHIEQDTELESAEIPIGVVDSISGITNCTAAVAGESNHAGATSMVDRRDALSAASEFVVDVERIAKEVTNDHPTAVATVGRQDVEPNVRNIVPGRVRMEMDVRSVNGDAIDTIVERSADRFERLEHERPVETDFERNRDMPPIELSDRCVDAIELTAERLDVESTTMHSGAVHDTGNVAAKTDAAMLFVPSRDGISHSPHEWTDWDDCAISARILAATALELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LID7</accession>
    <name>A0A3N6LID7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_15935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87114">
        <property type="protein sequence ID" value="RQG87114"/>
        <property type="gene ID" value="EA462_15935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="115"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="336" mass="39369" checksum="119596E5D4EE18F9" modified="2019-02-13" version="1">MSLEPIEPETALELYLADRENNVTEATIRSHRSRLGHFIRWCNNEEITNLNNLTGRKLHRYRLWRRDEGDLSPATEKTQMDTLRVFIRWVESIDGAPEDLHVKIRSPNLTGDDNVRDEMLEEERAEELLAYLRRYEYASRHHVVIALMWHTMIRVGAIHSLDVDDFDSEEKSLQVVHRPETDTPIKNSTDGERFIALSDKVCQLLIDWIEQRRPASVDEYDREPLITTSQGRAHTTTLRGDCYRYTWPCIRGEDCPHGRNIDDCPATEYERASECPSSESPHALRRGGITHSLQQDWPMKAVGDRANVSEQVLEMHYDQRTEKEKMEQRRDYLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIN8</accession>
    <name>A0A3N6LIN8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87796">
        <property type="protein sequence ID" value="RQG87796"/>
        <property type="gene ID" value="EA462_13060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="261" mass="28905" checksum="7F4CE75F6C18A7A9" modified="2019-02-13" version="1">MPSVPTGFKALPEPDLQTSFERADEYEFDFLEVPLHPLAECREIDGRSEDVRKAAADTGVDVVAHLPHKPRDIVCVASAREDRRTTAFENVERSIETASAIGASKAVLHLEAPETHLADDTERELFAVLDSLSEYGRTHGVEVCYENLSRRYPTLADFPQLLERTSASITLDTGHARVNGYSSPEIATFAGQHAGRISHVHLNDTRGRADEHLPFGSGTIDFESIFASLLEGGWDGTMTTEVKTHDFDFIRLGKEKLDELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ57</accession>
    <name>A0A3N6LJ57_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA-transferase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87891">
        <property type="protein sequence ID" value="RQG87891"/>
        <property type="gene ID" value="EA462_13595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="27326" checksum="D047C8277CEDD6C5" modified="2019-02-13" version="1">MTAYTDTELMIARAAQELENDDTTLVGVGVPNLACNLAKRTHAPDLEMIYESGTIGSNPSRLPLSIGDPVLATNARSVVPMTKGFGYYLQAGRIDVGFLGGAQIDRWGNINSTVIGDYDDPTVRLPGSGGACEIASNTDRTIIIAPHSRRRFPPEVDFVTSPGYVGGRDNRAELGLRGGPEAVITDMAVMHFDDDGEMTVDSIHPDVSKADVAEATGWDIQFASDLDETRPPTEDEIALIRNELDPDGVYTGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ87</accession>
    <name>A0A3N6LJ87_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87951">
        <property type="protein sequence ID" value="RQG87951"/>
        <property type="gene ID" value="EA462_13900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="72" mass="7836" checksum="2E8689C6E2DA8403" modified="2019-02-13" version="1">MTRSSTTDSSDREPIQDGSNTAIERTKNGGQRHDRKRSQMKTRHTNRPTNPASTDRSDAPAAASPLIGGDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJF2</accession>
    <name>A0A3N6LJF2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ORF">EA462_10385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88803">
        <property type="protein sequence ID" value="RQG88803"/>
        <property type="gene ID" value="EA462_10385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="85"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG88803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="309" mass="33024" checksum="D71306BA7CDB40AA" modified="2019-02-13" version="1">MSQADTTTAITTGGPGGIDDRKNAAIRYVFFSCAFVTVLTTLGIILVLVQGSLEFFQHVSIVEYLTGTEWSPVIRPHSYGVLPLIWGTLVVTVGSALVAIPVGTATAIYLSEYASPRFRKIVKPTLEILAGIPTIVYGFFALSFITPLLQQLFPRTGTFNAVAGALVVGIMIIPMVSSLSEDAMSAVPDDLRNAAYGLGATKFEVSTGVVVPASLSGVIASYILALSRAIGETMAVTLAVGMHPQISFDPLEPMQTMTAYMVQIGISDVSIGSIGYQSLFAVGLTLFAMTLSMNLISLWIKSRYREEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJH5</accession>
    <name>A0A3N6LJH5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88843">
        <property type="protein sequence ID" value="RQG88843"/>
        <property type="gene ID" value="EA462_10605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="877"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1368" mass="155302" checksum="424CBEA918AB2908" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJH7</accession>
    <name>A0A3N6LJH7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88101">
        <property type="protein sequence ID" value="RQG88101"/>
        <property type="gene ID" value="EA462_13970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG88101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="305" mass="32524" checksum="2C17D5EE5E72FDF1" modified="2019-02-13" version="1">MSAAVVLVGVSVLTFGLIYLTPGDPAETILSQQTDQQPSQEAIEAFRAEHGLNEPIPHQYVNWVGDALQADLGQSYYSDRSVNGMIVQHAPATVELAIAAMAIALLIAIPTGVLSAVHRGGRLDVVCQFGALVGVSMPNFWLGYLLIIGFSLHLGLFPVSGSGGLAHLVLPAVTLGTGVAAIIARLVRTSMLAELDREYLDVTRAKGLSERIVVYKHAFRNALLPVITVVALQFGFVLNGAVVVEIVFQRPGLGTLLVDSIFARDYPVVQGVVLVTAVSFVLTNLLVDLSYRYLDPRIRLGGVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK18</accession>
    <name>A0A3N6LK18_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA primase DnaG</fullName>
            <ecNumber evidence="1">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaG</name>
        <name evidence="4" type="ORF">EA462_11020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88918">
        <property type="protein sequence ID" value="RQG88918"/>
        <property type="gene ID" value="EA462_11020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00007">
        <property type="entry name" value="DNA_primase_DnaG_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020607">
        <property type="entry name" value="Primase_DnaG_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0271">Exosome</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0639">Primosome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="3">
        <location>
            <begin position="167"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="464" mass="49598" checksum="5EF6E61228391B7D" modified="2019-02-13" version="1">MEDTTKYLIHADVTADGVVERSDVVGAIFGQTEGLLGDDLDLRDLRQSQKVGRIDVEIASTHGNSRGHLTIATSLDKVETATLAASLETITRVGPCRAELAVSEIEDVRAAKRKEVVERAKELLQTGFDDTVMSSDEILAEVRQHVRVEDITEYEGLPAGPRVTDSDAIIVVEGRSDVLTLLKYGVKNAIAVEGTNVPDAVAELTRHRTVTAFLDGDRGGDLILEELSQVGDLDYVAFAPPDESVEELDHHQLFAALRKKVPYDSVSDLNEPRDAVAATDGSATPAPVPTDESSGTRSAVSPSGEAESSPGRGEQPTNGPETGPNATVAPSHPSTPERADSSPPARALETDDAVDETPEPASETVYDHADAVIRASTDRVRFVDADGETVDETDASEAYDALEAIETSPETVVIDGILSQRLLDLSADRDVDLVIARSLGQFTKRPTSVRVHAIDEIAEESPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK81</accession>
    <name>A0A3N6LK81_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86778">
        <property type="protein sequence ID" value="RQG86778"/>
        <property type="gene ID" value="EA462_16725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="54"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="5">
        <location>
            <begin position="313"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="404" mass="45076" checksum="82D55DD58F468E46" modified="2019-02-13" version="1">MSDSDDLFIRTDPIFVNKELLEISHLPEEGRIVGRDEEIGQLANAVNPAIFGQSPSNVLIYGKTGTGKSLCAKYVSRRLVSTAEEEGVEAVFAYVDCAQDTTETQAAQTIASSVNTDDTEIYIPDKGISTATYYKRLWRILDKEYDVALIILDEIDKLEDDAILMQLSRAGEAGKVTECKIGVMGISNKIKYKDRMDERVKSSLCEREFVFPPYNASQLNQIMTARSDAFREAVLEDGVIPRAAALAAREHGDARKAIDILRYAGEIAQANGADTVREDFVVQARERAEVDRFRELIRGSTPHSRYALQALTVLSLEHCADDLSHENDGFRTTRVYDVYEQICRQEGTDALSLRRVRDLLKEHAFLDVIEQSRHSGGSAEGSYTEHTLLENPKVVKDVLADTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKB0</accession>
    <name>A0A3N6LKB0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_11700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89038">
        <property type="protein sequence ID" value="RQG89038"/>
        <property type="gene ID" value="EA462_11700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="4">
        <location>
            <begin position="195"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="644" mass="67936" checksum="4ADD5EB202BCCDCF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKP9</accession>
    <name>A0A3N6LKP9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribbon-helix-helix protein, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87048">
        <property type="protein sequence ID" value="RQG87048"/>
        <property type="gene ID" value="EA462_15530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="6909" checksum="530B3917D22AC685" modified="2019-02-13" version="1">MERVTLRIPKQQIEEVEQLVDSGEFPNRSEAIRSAVREMINEQYDGQTDQTSKRSWAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LL86</accession>
    <name>A0A3N6LL86_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87830">
        <property type="protein sequence ID" value="RQG87830"/>
        <property type="gene ID" value="EA462_13250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009215">
        <property type="entry name" value="TIM-br_IGPS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09370">
        <property type="entry name" value="PEP_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034452">
        <property type="entry name" value="TIM-br_sig_trnsd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP_hydrolase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="277" mass="30156" checksum="32A185C8D832DDE6" modified="2019-02-13" version="1">MQFPREKSLERLRSVVESGQPIIGAGAGTGISAKFAEQGGVDLLIIYNSGRYRMNGRGSLAGLLPYGDANEIVVEMGHEVLPVVEDTPVLAGVNGTDPFRQMDVFVEDLKRRGFSGVQNFPTVGLFEEGTQFRRNIEETGMGYDKEVDMIQEAAEQDMLTCPYVFTEEQAREMAEAGADVVVSHMGLTTSGDIGAETSLGLEEAAERVQAHHDAAKAVNDDIIVICHGGPIAWPDDAEYVLHNTDGVVGFFGASSLERLPTEEAIRNQAREFKEIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLB8</accession>
    <name>A0A3N6LLB8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87880">
        <property type="protein sequence ID" value="RQG87880"/>
        <property type="gene ID" value="EA462_13535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="95"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="368" mass="40332" checksum="D025A63B11C3D84B" modified="2019-02-13" version="1">MPHRTGSGRRTILKTVGAGVTVGLAGCMGNGDDDNGASDSDTSGSDDIGDEQSDDDMGGEVEIPNPLRIGHPSPAMAGYSVPTYSLFNEEMESRGVEIEPVVFNGFTAMVAGIVSGEVELGYSNPPAIINSIREGFPISSFLELNQKFSQQIIAQPDIESWEELEGAPVAAHSPQSFSALTLRATAESQLGDPEAFDLSYIAGTPNRISAMEEEEVDATTVFASAAIDVEERDIAQWFHNPNDDVAAEPLSLAQWVTTDDRLNEYEEVYRTIAEELTNSYEQAYETDPQELAEMIFDSPAEFPAYDSGDIEVWEQTIEAAQEDEMWETDMSNMLTDERVSRSIDLAERTGLIDEVIEVDDLVDRRFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLG5</accession>
    <name>A0A3N6LLG5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Isochorismate synthase</fullName>
            <ecNumber evidence="9">5.4.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_07340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isochorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89823">
        <property type="protein sequence ID" value="RQG89823"/>
        <property type="gene ID" value="EA462_07340"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="8">
        <location>
            <begin position="188"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="452" mass="49346" checksum="E9484C761D2B03DB" modified="2019-02-13" version="1">MERTSGGRGLAAESASVEHEEPIDLVSCSRDVTDVSFGAIVDTDDEPRILWTAPNGLEIAGRGVAARFTAAGPNRFERIRTSADRVFDALEHDGPPVARPRAFGGFSFHDGHAPNPPWTGFDAASFVVPRAFVTRDDTGGIWVTAVGNGPDDAYDRLDHWHERLTSGPAMRASGSGPGVTSTRRSTSPEEWNEQIESALGRIEDGRLTKVVLAQALSIDLESSVDVPTMLERLRRQYPNCYRFLVSHETGGTFFGAPPEQLVSKRDDRVETEALAGSVARGETPESDDELATRMLADEKLEREHELVVEAIRDQLEALACELAIGDRRVRKLNTIQHLRTPLSATLAGDHHVLELVEALHPTPAVGGVPPTNAWETIRQTEAFDRGWYAAPIGWFDADGNGEFAVALRSALAVDDTVTLFAGNGIVADSDPAEEWTEVQLKFRPILDELKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLQ3</accession>
    <name>A0A3N6LLQ3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="11" type="ORF">EA462_08060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89953">
        <property type="protein sequence ID" value="RQG89953"/>
        <property type="gene ID" value="EA462_08060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="10">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="141"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="235"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG89953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="324" mass="36182" checksum="C3D069F42955EE1A" modified="2019-02-13" version="1">MTDTRIRTYTNERPEDETESTDVDERERCPECGGRVISDDEHGETVCAECGLVVDEDEIDRGPEWRAFDSAEKDSKSRVGAPTTNMMHDQGLSTNIGWQDKDAYGKSLSSRQRQKMQRLRTWNERFRTRDSKERNLKQALGEIDRMASALGLPENVRETASVIYRRALEEDLLPGRSIEGVATSSLYAAARQAGTPRSLDEISAVSRVDKMELTRTYRYVIRELGLEVKPADPESYVPRFVSDLDLSDETERMARELLDSARNEGVHSGKSPVGLAAAGVYAAALLTNEKVTQNEVSQVASISEVTIRNRYKELLEASDSAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLW0</accession>
    <name>A0A3N6LLW0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90033">
        <property type="protein sequence ID" value="RQG90033"/>
        <property type="gene ID" value="EA462_08490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="373" mass="40265" checksum="7C9601D8996AEB8B" modified="2019-02-13" version="1">MTEFSHRVEQVSISGIRKVFEAAGEDAINLGIGQPDFPTPEHACQGAIDAIENGRTDAYTSNKGTHSLREAIATKYDREYGLEIDPEDAIATSGGSEALHLVLEAHVDPGQEVIFPDPGFVSYDALTRIADGTPKPVSLREDLTLDPAAVEAAITDETAVFVVNSPANPTGAVQSEADMREFARIADEYDVLCLSDEVYEHIVFEGDHRSPLEFSRTDNVVVVSACSKTYSMTGWRLGWVVGSTRRIERMLRVHQYAQACASAPAQYAAEAALTGPQEPVDEMVAAFERRRDVVLDGLEDAGLEVPTPQGAFYVMPKVPEGWCEEVLDRDVIVVPGDAFGANGEGYARISYATGIAELKGALEIIDDATAAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM21</accession>
    <name>A0A3N6LM21_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88787">
        <property type="protein sequence ID" value="RQG88787"/>
        <property type="gene ID" value="EA462_10290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="107" mass="12081" checksum="AA0E3AAAE9DC16F5" modified="2019-02-13" version="1">MSSPPPETETHEVTLSIEEQWVVHHVLADRVDEALDAEKTPPSWTMSAFETIESDDDPETFTGRQIRNLSGELATYVDRDETPERDLVHGSAVLERFEDALPSDSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMC1</accession>
    <name>A0A3N6LMC1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86665">
        <property type="protein sequence ID" value="RQG86665"/>
        <property type="gene ID" value="EA462_16105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="126" mass="13527" checksum="9C33B573F5291731" modified="2019-02-13" version="1">MKEVSTPNAPPSIGPFSQGLVDDGTVYVSGQGPIDPETEAIVGEDIEDETHRTMKNIGAVLEAAGSSLDDVVKATVFIQDMDDYDAINGVYEEYLSEPYPARSAIQVEDLPVDIGVEIEIIARVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LME5</accession>
    <name>A0A3N6LME5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86695">
        <property type="protein sequence ID" value="RQG86695"/>
        <property type="gene ID" value="EA462_16275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="189"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="293" mass="30689" checksum="2144C17D2D6CDBAB" modified="2019-02-13" version="1">MELPVQVLLALGTAAAFATSSVLVRFGVERSTPMAAMFATISVNVVVLWAISLALYDVTVDLWAWRYFILAGLFAPVIGRLCNYIGLERVGVNLTLPISNSNPLVSVVLAILLLGETLTRQGGVGALAAIAGGILLATAGRGDGSAVDVRYRDLLFPIAGAVIYGSVQLLRNVGMELVPEPAVGAAVNLTTSWLVAAAFFAVASNHRAALSIPFADLRYFVLAGIASSLGLICLYAALRSGTVVIVTPILNTTPLFALVFTFVFLREREPFTPQVISGTVLVVVGVGLLATST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMX1</accession>
    <name>A0A3N6LMX1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89247">
        <property type="protein sequence ID" value="RQG89247"/>
        <property type="gene ID" value="EA462_12855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="88" mass="9687" checksum="79FD47FFEDE98D50" modified="2019-02-13" version="1">MPRYEVTIEKDACDGVFACLTRDPRFVEDEDGLATIDPGADPVYDCEGELTETAERVVATFDDDRIDEARRAATACPTDAIVVDEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LN96</accession>
    <name>A0A3N6LN96_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87065">
        <property type="protein sequence ID" value="RQG87065"/>
        <property type="gene ID" value="EA462_15645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="144" mass="15745" checksum="BB55E2EB90944A95" modified="2019-02-13" version="1">MTDHILVPVDDSNRSTQAIEFACREYPNATITALHVLDPGDFYAATGLEGGAMVNYDEIHQQHERQAETVLENARELAAEHGRELETEQMIGSVSRSIVDYADEHDVDHVAIGSHGRTGASRILLGSVAETVARRSPVPVTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPS2</accession>
    <name>A0A3N6LPS2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_10885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88894">
        <property type="protein sequence ID" value="RQG88894"/>
        <property type="gene ID" value="EA462_10885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="224" mass="24314" checksum="47CB7E1026F0DE2C" modified="2019-02-13" version="1">MASGIRAEVTIDDPPNCVVTAVAGETDGNVHSVSKSTNPVACDRVTEEFVLEAETAPDEVDVEADLSTIFSYGSSAVYRFDRELGRGCPCESVERFDCPVTEVRARGSSLHLTFHAPDMEGLQSIIGELIEQYPTLDVKRLLQSEQEHSAGNLVFVDRSTLTDRQREVLETAHRMGYFDHPKRSNAGEVAAELDITGATFAEHLAAAQSKLLDAILDGESTGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPV4</accession>
    <name>A0A3N6LPV4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91553">
        <property type="protein sequence ID" value="RQG91553"/>
        <property type="gene ID" value="EA462_06230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011589">
        <property type="entry name" value="UCP004961"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42206">
        <property type="entry name" value="PTHR42206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004961">
        <property type="entry name" value="UCP004961_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="286" mass="31488" checksum="083B412678A3FCF1" modified="2019-02-13" version="1">MIDDETPVLDNHLHLDPDNHRGIDAVRDFARLGGTHLLVVNKPSWHLGVEAESGADFRPVFERTLEIVAAATDELEGRAWPVLGVHPGLISRLVDERGYTADQAREIMQGGIELAAEYVESGDALAVKSGRPHYDVDDEVWEASNAVMRRAFERAADLDCAVQLHAEASEDMTEVTEWADDVGLPAHRVVKHYAGGRLEGPVPSVTGQKDPLEVAADRGEPFLMETDYIDDPDRPGAVLGPKTVPRRVAWLLETGYDDAVRNAHVETPAMVYDIDTEGTLERSRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPW6</accession>
    <name>A0A3N6LPW6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91573">
        <property type="protein sequence ID" value="RQG91573"/>
        <property type="gene ID" value="EA462_06360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="74" mass="7802" checksum="91DE956C723BAD80" modified="2019-02-13" version="1">MVLQRFLGSKATRSLTVVSVLMEAKRALARGRRTRGLVLLGVAVVAWKWTVIGLAAQGVIKALRAGRPSGSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPY2</accession>
    <name>A0A3N6LPY2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88974">
        <property type="protein sequence ID" value="RQG88974"/>
        <property type="gene ID" value="EA462_11330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="414" mass="46207" checksum="8C28DF7EA195DA02" modified="2019-02-13" version="1">MNDRYDVVIAGAGPAGSQCARDLAARGYDVVVLETEPEDQFPRQSNKSTAGTFPSMMASFGIPDDVVMQYTDSVVLESPTDHYVREQPGAVLEFAEFKRFLVSDGRADGAEYRFDARVTAPIMDGGEIVGVTYNGDEEVYGEIVVDATGPAAPLAKKLDLVELERENHAIGIEYEFEGIDIDRPGFADLHDAMMLRLDHAIAPGGYSWIFHTGEDTAKVGLCYIQNDIHQRYARESFTIDDYLDHWLETDPRFQNAERLEGKQHRGSAHIQRPGKMHTDRFMAIGDTVPTVDPLWGEGINKCMQSGRMAAAAADSCLKHGDLEPTADNLEVYETLWHREVAPNVRSRLWMTKLLYFASNERYNTLMEDLNRFDNETLAKANRGNPFAVAKLLQLGDIPMLARLVAQEYGFGSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ02</accession>
    <name>A0A3N6LQ02_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">dnaJ</name>
        <name evidence="9" type="ORF">EA462_06735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91638">
        <property type="protein sequence ID" value="RQG91638"/>
        <property type="gene ID" value="EA462_06735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="5">
        <location>
            <begin position="161"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="5">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="5">
        <location>
            <begin position="204"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="5">
        <location>
            <begin position="218"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="387" mass="42042" checksum="4B2C9D4331AA74A9" modified="2019-02-13" version="1">MSEDFYDVLGVGPDASAEEIKQAYREKATEYHPDVSDDPNAEEKFKKIQKAKKVLTDEDKRSAYDRMGHDRYEQAEKHGYDASGGGMGGDPFGGMGGGGMGGGGMGGGLGDIFEQVFGGGGGRGRRRPRSGRDLRTNIEIDLEEAFEGAEKQFTVERPERCDACDGEGHPPSADAETCPECQGRGQVTQVQQTPLGRVQQTTTCSRCEGDGTLYSETCSECRGEGYVRNEATLTVEVPPGIQDGQTLRMEREGAPSPEGGANGDLLIDIIVRDHEQFERDGDDLRYRLPISFPQATFGDTVSVPTLDGTVEFDVPTGTQSGEIFRLEGKGMPRLRGRGQGDLFVKVQIVTPKTLNEEQREALEAFAEAGGDEIEVAEGFFEKIKRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRQ5</accession>
    <name>A0A3N6LRQ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89844">
        <property type="protein sequence ID" value="RQG89844"/>
        <property type="gene ID" value="EA462_07450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="115" mass="13415" checksum="8B6DE37D1A6BBA12" modified="2019-02-13" version="1">MSEEIDLSRILAILDDEYARDILTHTSVEPMSASTLSERCDASLPTIYRRLERLEESRLVTEETELAPDGNHYSVYSANLDRFELSLEEGSFDLELTYREEDVADRFTRMWEGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRZ5</accession>
    <name>A0A3N6LRZ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91247">
        <property type="protein sequence ID" value="RQG91247"/>
        <property type="gene ID" value="EA462_04450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="349" mass="36948" checksum="CBE55EA5EDA5199D" modified="2019-02-13" version="1">MTADGAAASDGAETGDGAGTAAVTGATGFLGTHLCERLLENGWTVDGLCRPTSDRGGIDNGDDSNEQNGLEDVNWHVGDLFDRRTLESLVDGADAVFHLAGVGLWSATPDTVERVNRDGTAAVLRACRASDVGRLVFTSTAGTRRTNGTGTFADERDVAEPIGAYQRSKAAAEGLVDRYARTEGDAVTVHPTSIFGPGDGSFTAQLIAMGTEPTMPAYLPGGLSIVGVSDVVDGLLAAYRSGTSGEHYILGGENLTYDRAVSRISDNTGGSPARLPVPSAAIHAAGPVVEAVGTVTDRQVFPFDRQMARLATRRLFYTSQKAHEELGYEYEPLEAHLPETMSWYRHRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS59</accession>
    <name>A0A3N6LS59_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HPP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92703">
        <property type="protein sequence ID" value="RQG92703"/>
        <property type="gene ID" value="EA462_00255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="169" mass="17356" checksum="BD3135124D773EE0" modified="2019-02-13" version="1">MDDRAGTTLHTGLLISTTAVIAWLFGLPMLFPSLGPSAFVLALFQDSEATSTRRVVGGHAIGVVAGLLAYHLLAAGISMTATTAPGSLEGLRLAASGVLATTLTAGGMLATDTRHPPACATTLIVSLGLLTTVLEGVMIVLAVVVLVSTHRVLLASERIGPRYGKRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSA8</accession>
    <name>A0A3N6LSA8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92783">
        <property type="protein sequence ID" value="RQG92783"/>
        <property type="gene ID" value="EA462_00710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="7134" checksum="90484AA933553EAC" modified="2019-02-13" version="1">MAKGTVEFFNDTGGYGFIESDDSDEDVFFHMEDVGGPDLEEGQEVEFDIEQADKGPRATNVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSK3</accession>
    <name>A0A3N6LSK3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class A beta-lactamase-related serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91487">
        <property type="protein sequence ID" value="RQG91487"/>
        <property type="gene ID" value="EA462_05860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="694" mass="74116" checksum="5ADB8DD13052260D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT57</accession>
    <name>A0A3N6LT57_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93193">
        <property type="protein sequence ID" value="RQG93193"/>
        <property type="gene ID" value="EA462_03055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="145" mass="16320" checksum="CD9F9809D646737B" modified="2019-02-13" version="1">MHPKAKGANDTGGEQGTPGAFDSWTALQKATDRTRANLIADIVGHPKGAPSVKELDYMNPSLEADAIRRHLSILRDVGVVTELEVEPGNRIRGYPYKFYRLSDPARELFDRNDLFPTDAWQRQYARVQRTGEIKDLEAMPRPTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUM3</accession>
    <name>A0A3N6LUM3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegT/DnrJ/EryC1/StrS aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91264">
        <property type="protein sequence ID" value="RQG91264"/>
        <property type="gene ID" value="EA462_04545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="373" mass="41417" checksum="85F7997DFDEF205F" modified="2019-02-13" version="1">MISGTPSLFVSSLSSERPTGIEQFVDGHTRAYTYYGSGKAALRDGLSDLVEPGENVLVPAYLPDGVVEPLIELGLEPRYYRIRSTLAPDFGDVEARIDTNTVAVLSVNYFGFPQPGLSELSDLVSEYDCYHVDDNAHAPLSVDDGTLLGTRGHLGITSLWKLFPVPDGALLYCNDDDVADRYEPSSLAGIQDGLDRTDIRFVAKSILDDVFDADGTVRQSISAIVSGRGGSPSVGTPQKRYERRKTRMSKLSYRVVEDADPIGIRRTRRENYRRWRTLLTDRDDVELVYESLPEGICPQVFPVRTDRPEAFLAELEQCGIGGVHTWPRLSSSVVEEPAYETARRLSRDVLTLPVHQHIEPSTIEAVGSELRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV39</accession>
    <name>A0A3N6LV39_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91514">
        <property type="protein sequence ID" value="RQG91514"/>
        <property type="gene ID" value="EA462_06010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="6797" checksum="3FC284C8F7B6A0DA" modified="2019-02-13" version="1">MPTERPLAFLDVGFALLWLLEALVEGDLVRTCSISGSEPVNSITSSARSLMLVGTGDPTLYTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ30</accession>
    <name>A0A3N6LZ30_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87012">
        <property type="protein sequence ID" value="RQG87012"/>
        <property type="gene ID" value="EA462_15315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="159" mass="18292" checksum="D26DF86C9A4B09CE" modified="2019-02-13" version="1">MPSYDRRTIIDAPLQDVWQFYSRASGLEDVTPDWVDLRVESVIGSDGRLGPDVLEPGSELSVSIRPFGLGPRQYWLSVITERERADGAAYFRDELEHGPFDEWVHTHSFFAHGDRTVLRDEIEYELPLGPLARFGRPFSRIGFEAMFRARHRLTNEQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M064</accession>
    <name>A0A3N6M064_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="11" type="ORF">EA462_11420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88990">
        <property type="protein sequence ID" value="RQG88990"/>
        <property type="gene ID" value="EA462_11420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="10">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="143"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="237"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG88990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="326" mass="36120" checksum="92BCC4FDAE18077B" modified="2019-02-13" version="1">MTNAPANTRVRRSEHEQTDEQTEHEQSDLACPECSGNLIVDDEHGETVCEDCGLVVEEDSVDRGPEWRAFDAAEKNEKSRVGAPTTNTMHDKGLSTNIDWRNKDAYGNSLGSRQREKMQRLRKWNERFRTRDSKERNLKQALGEIDRMASALGLPTNVRETASVIYRRALDEDLLPGRSIEGVSTACVYAAARQAGVPRSLDEIADVSRVEKNEIARTYRYVVRELGLEVQPADPESYVPRFASGLDLSDEAEHRARGLLQNAKEKGVHSGKSPVGLAAAAVYAAALLTNEKTTQAAVSDVADISEVTIRNRYHELLEAEETLGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0L7</accession>
    <name>A0A3N6M0L7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="7" type="ORF">EA462_12500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89180">
        <property type="protein sequence ID" value="RQG89180"/>
        <property type="gene ID" value="EA462_12500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="6">
        <location>
            <begin position="194"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="223"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="429" mass="46701" checksum="A20DCE7005D96678" modified="2019-02-13" version="1">MTDSSYPPISEQLDDLDEARTKGRRKMDWAAQHMPILEHVREEFLADQPFEGERIAMAMHVEAKTAILVETLAEGGAEVAVTGCNPLSTHDDVSAALDTHESITSYAKRGVNDEAYYDAIEAVIAHEPTVTVDDGMDLVAAIHEEYPELIDGIVGGAEETTTGVHRLRAMDDDGALEYPVFAVNDTPMKRLFDNVHGTGESSLASIAMTTNLSWAGKNVVVAGFGYCGKGVARKASGQNANVVVTEVEPRRALEAHMEGYDVMPMAEAAEIGDVFLTTTGNRDVVVREHFEEMQDGVLLANAGHFDIEIDLEALDDLAVDRYEARDGVEAYEMADGRRLNVVAEGRLVNLAAPVSLGHPVEVMDQSFGVQAVCVREMLENSDAYDAGVHDVPDELDEEIAEIKLAAEGVEFDSLTETQREYMGSWDHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0Z3</accession>
    <name>A0A3N6M0Z3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">GMP synthase [glutamine-hydrolyzing] subunit B</fullName>
            <ecNumber evidence="5 12">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">GMP synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">guaA</name>
        <name evidence="12" type="synonym">guaAB</name>
        <name evidence="15" type="ORF">EA462_10260</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="5 12"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88781">
        <property type="protein sequence ID" value="RQG88781"/>
        <property type="gene ID" value="EA462_10260"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00345">
        <property type="entry name" value="GMP_synthase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026598">
        <property type="entry name" value="GMP_synthase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="14">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="29"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RQG88781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="305" mass="33800" checksum="D27A818F130952A3" modified="2019-02-13" version="1">MVDTETFTPDAVEEIETEIGDENAVIALSGGVDSSVAAALAYEAIGDRLTPVYVDTGLMRKGETEQIRETFSYMESLRVVDAKDRFLEALSGVSDPEEKRAIIGEQFIREFEREANDADADYLVQGTIYPDRIESEGGIKSHHNVGGLPEVVDFDGIVEPVRDLYKDEVREVARHLGLDELVAERMPFPGPGLAVRVIGPVTEEKLEVARDACHVVEDELEEYEPWQALAAVIGKATGVKGDNRVHGWVVSVRSVESRDGMTARAQEIDWETLQRIQSRITGTNENVARVVYDVTHKPPATIEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M152</accession>
    <name>A0A3N6M152_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AbrB/MazE/SpoVT family DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88801">
        <property type="protein sequence ID" value="RQG88801"/>
        <property type="gene ID" value="EA462_10375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="333" mass="36494" checksum="2DC14679F4DC02C6" modified="2019-02-13" version="1">METRKVQVTGGSTYTVSLPKEWATDNDVSAGTTVECYPEDDSLLLTPQSDTQRQQGTLDVSDLEGERLTRAVMTMYVSGFDIIRLEAGRITTDQRRAIRDATQSLVGVEVLEETSGSVVIQDLLDSSELSIVNAVSRMRLIAISMLDDAITALIENDDDIAHDVIERDDDVDRLWLVVSRIFRATLRSPRAAEELGVPREDCFDYHSSARQLERVADHAAKISNLALKLEEIPESVAEALAALRTDAGDVLEKAMDALFADESDEAIRLGHAAREAVLEIDEHTRTIDDMLRDLEPVQAQSLGLIVDSLSRSADYGGNIAETALQKAAPRPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M232</accession>
    <name>A0A3N6M232_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89161">
        <property type="protein sequence ID" value="RQG89161"/>
        <property type="gene ID" value="EA462_12400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="128" mass="14334" checksum="D3E19A3CB3781218" modified="2019-02-13" version="1">MSPDHPPIPREALPPGWGLAEHRDDRFSYRCSRLPIELVADATIPRPPPGLGLCRCWELRYSYSLGEQPISEAIGRVSTRHAATEGLLECMNRVHETVEDAEDVLYVRTVLERVSLSSLVPERVSESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4D8</accession>
    <name>A0A3N6M4D8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87027">
        <property type="protein sequence ID" value="RQG87027"/>
        <property type="gene ID" value="EA462_15405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="71" mass="7945" checksum="FD96F149781B6C08" modified="2019-02-13" version="1">MVTEARRIYEPRVAPVIGVSLGGAALSGYLGNVGVFLLCGFAVSFLVWKMWESEKRWRNLEREENAVTQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M514</accession>
    <name>A0A3N6M514_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90341">
        <property type="protein sequence ID" value="RQG90341"/>
        <property type="gene ID" value="EA462_10225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="66" mass="7417" checksum="358B86B878C9104D" modified="2019-02-13" version="1">MSDLTAFGLEPRDSPEDDDENELSETVSETWSECVDCEYVGYEVKARLQHSVPLCTACFAEREGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5P9</accession>
    <name>A0A3N6M5P9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88089">
        <property type="protein sequence ID" value="RQG88089"/>
        <property type="gene ID" value="EA462_12955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="113" mass="13048" checksum="A9ED5D3401F63A70" modified="2019-02-13" version="1">MYVEGTDDWLVVGELTDVCELVGGETYSIEYGRAGRMADWVETDDQGNFTFDVRETLAEFTFDEEFVTHLEQVELESDDDEAYPYRTEFFADMMTTIWDAKGPLETSTDDQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6C3</accession>
    <name>A0A3N6M6C3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF192 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91610">
        <property type="protein sequence ID" value="RQG91610"/>
        <property type="gene ID" value="EA462_06575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="117" mass="13333" checksum="23BC0BA368B6D419" modified="2019-02-13" version="1">MKLVHEPDDGEEAVLASRVDLADSVLSQTRGLMFRRSLPDEYALAFRFDAPSTRDVHMLFVFVPLDVVWVDDGTVRRVERLRPWRGFARERADLIVELPAGAAEEVDPGDRLVLEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M778</accession>
    <name>A0A3N6M778_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">glpA</name>
        <name evidence="15" type="ORF">EA462_12635</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89206">
        <property type="protein sequence ID" value="RQG89206"/>
        <property type="gene ID" value="EA462_12635"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017752">
        <property type="entry name" value="G3P_DH_GlpA_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03377">
        <property type="entry name" value="glycerol3P_GlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="13">
        <location>
            <begin position="6"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="14">
        <location>
            <begin position="437"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="539"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RQG89206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="573" mass="62459" checksum="D916A97C01CAB6F0" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7Q8</accession>
    <name>A0A3N6M7Q8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell shape-determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91371">
        <property type="protein sequence ID" value="RQG91371"/>
        <property type="gene ID" value="EA462_05185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01011">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="491" mass="52976" checksum="AD40D0ABAC964A3A" modified="2019-02-13" version="1">MGFFSSAHRRRTRTGVNGPNTGSDRSRVEPERPGTELEEISRRGLLAGVGAVGSLSLVGSSARVGRTIPGCERAAADAGPEHVPRPVDDDVTMFRRGLRRYGYYPDVTVPDEVRVDWSTPVNRIGHTAAKSTPRPTSDGETILVAADTGVIRALTPEGNERWRLETGASRSLGFHGTPAIVGDVAYVGGYDGVLYAIDVESGELIWRTGIREFDGAIAIGSSPAYIDGRLYLLAEYSDPASGALWEIDAETGTPTWSDDRIWGMPHPSPAIDCDAGRLVTGSNDGVVYCWEFPSLEFAWSFQAGGEGGPDGESMAGGRFNLGAEIKGTTPVYDGAAFVGSWDGRFYRLDLADGSEEWSFETGQVIMSNPAIDPDEGVVYVGGDDRHVHALDAETGDELWSTNVRGHVIGSLTATADAVLVGSYDTHLYALEKETGSRRWRVENRGHVTSGPIPRGGRIYYAERGVFSNFWDDSEETVFEEPGHAYCLVADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M904</accession>
    <name>A0A3N6M904_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small multi-drug export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92740">
        <property type="protein sequence ID" value="RQG92740"/>
        <property type="gene ID" value="EA462_00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009577">
        <property type="entry name" value="Sm_multidrug_ex"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06695">
        <property type="entry name" value="Sm_multidrug_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="190" mass="19837" checksum="EF61890A254BD3DE" modified="2019-02-13" version="1">MIDGPSSALSGALFSTPSLQFASVDILFAGAEERARELLSESDGIGQYLLVFLLAATPLLEILIVIPIGVALGLNPILVASVAFAGNVMPVYVLLVASDRVRSMLAARRSDSPPSKRRRRAKRVWDSYGLPGLALSAPIVTGVHVGALIAVGLGATRQSAIVWMTASIALWTVVITVLSVTGATFLSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MA23</accession>
    <name>A0A3N6MA23_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KEOPS complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93170">
        <property type="protein sequence ID" value="RQG93170"/>
        <property type="gene ID" value="EA462_02910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016799">
        <property type="entry name" value="UCP022062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022062">
        <property type="entry name" value="UCP022062"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="SSF143870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="196" mass="21242" checksum="43DE0223A69D138E" modified="2019-02-13" version="1">MRTLECRLAIDDLDGFVAALGDIGDRTGTTVQAFDARYVADRRHLKRALELADRSIARGENVARDRAVEILLYAAGRRQIDRALEMGIGERETRAVVLVDRRPDGGDCSRADTDDGNGIGGTDVSDAESEAVDAESEAVDAIRDLEAFVGEEPTLDSPDETTLCAFFDVTDAEREATDASLGALVRERVALLEVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC69</accession>
    <name>A0A3N6MC69_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93081">
        <property type="protein sequence ID" value="RQG93081"/>
        <property type="gene ID" value="EA462_02425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="13425" checksum="B5FDC779DAB9E411" modified="2019-02-13" version="1">MTTENSSDNLDRLLNKRCSEDPYRLPHEKETGIHLKGDEDHISVTSFKEVVYGKLLRRPDFDLDQLIIQDVDGREYTVDSLEEVLADPAVQIVGANGKLPAGALSIRKPRNSDSHARIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC93</accession>
    <name>A0A3N6MC93_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Xanthine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_02590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93111">
        <property type="protein sequence ID" value="RQG93111"/>
        <property type="gene ID" value="EA462_02590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="528" mass="55421" checksum="C2C4460EB0C02E1A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCF9</accession>
    <name>A0A3N6MCF9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93181">
        <property type="protein sequence ID" value="RQG93181"/>
        <property type="gene ID" value="EA462_02985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032604">
        <property type="entry name" value="DUF4897"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16238">
        <property type="entry name" value="DUF4897"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="409" mass="44633" checksum="ECE25B511416A24B" modified="2019-02-13" version="1">MDERGLRALVCVLVVLGCSVALVPSVSAAVVADAGMESPAYQELNESEQETEDDGAVNESDGADESNGTDDDGNESEQGQNESTALNESDQLDDADEVHIDVSLHENGSATFVVDYRFGNDSTENWEALRDDVEANSEAYAEKERNDWNEILVEGANETGRDMEISDVTVETDTSSAPRNMGHVEFTFRWSSFAHVELNRIEAGDALAGFTLVDDTTLQFFWPEEYAVREIDPSPDDPPDNSIFWDGDGTEFTDEQPWIVLIKNGGTADEAVEVTESPAMPWLAVLGALLLLAAAAAVGWLIRHRADGIGSNDDHSTGSSPPSTETREPIEPGERGTGPPSDLLSNEERVLQLLEERGGRIKQQEIVSELEWTEAKTSQVVSGLREEDEIDVFRIGRENVLAIPEDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCJ1</accession>
    <name>A0A3N6MCJ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_03180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93211">
        <property type="protein sequence ID" value="RQG93211"/>
        <property type="gene ID" value="EA462_03180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="8"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="28413" checksum="A2E7B988EF995953" modified="2019-02-13" version="1">MTHSGSAVSLEDVRKTYQLAEAVHALDGVTLEVPRGSYTAIMGPSGSGKSTLMNLVGCLDTPTEGRVIVNGEDVTELDSRERTDLRGTQVGFVFQTFNLMPRLSALENVALPQLFQGASRRQRRERARRLLERVGLADREDHLPNELSGGQRQRVALARALVNDPAIVLADEPSGNLDTDTEADVLDLFSEFHEGGTTMVVVTHERHVAERAERIVHLLDGRIERIEQLESGAGSDGIADEQGEEAVDETSESGAGGDGEATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGE7</accession>
    <name>A0A3N6MGE7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_02045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93016">
        <property type="protein sequence ID" value="RQG93016"/>
        <property type="gene ID" value="EA462_02045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="37"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="172"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="242"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="298"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="5">
        <location>
            <begin position="392"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG93016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="494" mass="54938" checksum="35782704043613BB" modified="2019-02-13" version="1">MTNDVSRDVSLPAFLLDDLEEAVDDRLQIAGVKNHIDILHVDDNHNIGTLVAEFLRRENGSFEIRTETHPADALEAIDRDDADFDCVVSDYEMPGMNGLELLEELRKRYSDLPFILFTGKGNEEIASEAISAGVTDYLQKSTGTDQYEVLANRIQNSVRGYRAENHAVRGFRAMNQAPIGITITDPRKADNPIVFVSDGFVELTGYPRSEALGRNCRFLQGEHTDDETIRDVRDAIRNEGPVTVEMRNYRRDGSEFWNRLDIAPIRDETGTVTHFVGFQQDVTARRELLAEFEALGDVLSHDMMNPIQTIRGRLRLALETGEETHVDEALPALERLEHLITDISEVLKAGSIVSEQTRLEVGTLAESVWDALDSYDTDGTLSIDGAPEIVGDERSVTRLLDNLLGNSLEHGTGEVTVRVGELTDGFYVADDGPGIPEQNREKVFEQGFTTKEENGGTGLGMASVRQIALAHGWRIYVDDDDTLGGVRFEIRTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MR94</accession>
    <name>A0A3N6MR94_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86773">
        <property type="protein sequence ID" value="RQG86773"/>
        <property type="gene ID" value="EA462_16700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="118" mass="13114" checksum="C69A1AD8602D9B60" modified="2019-02-13" version="1">MNVLITDDSGFMRDLLREILEEDHTIVGEAENGVEAVELYREEQPDIVFMDIVMPIKDGIEATGEITDMDSNAKVVMCTSVEQAEQMKDSIKAGAEGYITKPFQKESVLEELNSIAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MT37</accession>
    <name>A0A3N6MT37_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87945">
        <property type="protein sequence ID" value="RQG87945"/>
        <property type="gene ID" value="EA462_13870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="32"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="271" mass="29229" checksum="2E1A325B6337D20D" modified="2019-02-13" version="1">MFLMAPVVFVDMRIQTNGIEVECRVEGRGRTVVLVHGLGSTLSTWEGVAQSLSSSYQVVRFDLRGSGRSDVPDGPYDLETWVDDIDGILAELDVETAHFVGHSLGSIISMRYALEHPDAVSSLSLAAAGPGMPEEKVSEAQTVVDAIESDGMEAHADTEVEESLSPHTRETRPELAGLYRDLILNNDPDGYVASMRGLMNADLRGDLADVPVPTLLIAAENDVVTPPVASFIISDRIPDSEVTVLQHAGHMAQLETPAELARSVHDFIANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTB2</accession>
    <name>A0A3N6MTB2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88035">
        <property type="protein sequence ID" value="RQG88035"/>
        <property type="gene ID" value="EA462_14385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="160" mass="18095" checksum="CA556C66316589DB" modified="2019-02-13" version="1">MPGRDESTTVRIEPYNHGVQEHPLRHPADIVRHHYDYGYKETSILLFDNLNERGVRAAGKRFLPLYGVGGYFVLLVLTIAVGGVQGAVTVVDRIAPSILRLILVCLWFCTPLLIYWDCQAAERYLRQDWSGGKLNALLGIFVGPGALFLQVLYRIRKLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MU30</accession>
    <name>A0A3N6MU30_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88892">
        <property type="protein sequence ID" value="RQG88892"/>
        <property type="gene ID" value="EA462_10875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="150" mass="16897" checksum="3F0DF72FF7224965" modified="2019-02-13" version="1">MAINQEVEMTDAEIDEFLGRNETGVLSLARSDDPYAIPISYGYDASERAIYLRLVSTAESEKRDFLDSEPDARLVVYDEAQSTYRSVIATGALCNIPPSELTPNEIAQYGQAKRPLFEIWAQGTDELDIELYRLAPVSLEGRRTDVEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MU57</accession>
    <name>A0A3N6MU57_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88922">
        <property type="protein sequence ID" value="RQG88922"/>
        <property type="gene ID" value="EA462_11040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="220" mass="23483" checksum="E5F0A55B9954E8E9" modified="2019-02-13" version="1">MTADLPESLAGAWQPHATHADELTVLFASISAETTVFEPVETTPLEAALASELPVRSLFVVELSFSPPLPSLGVSPASVHSKAVSRATDQLVSLLTDAGVIVDGVRERLEFEAPNGKPGTWSVVDVRYPIADGRSVDATNGTDDADPIRAEAHVAVWPGERTFGVAGGTLPLERPDRFRTNTAAVSDGRSDENRTVEIDPERDRETVSTLISDIDLDADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MX20</accession>
    <name>A0A3N6MX20_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-oxoacid:ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_08480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90032">
        <property type="protein sequence ID" value="RQG90032"/>
        <property type="gene ID" value="EA462_08480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="6">
        <location>
            <begin position="202"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="287" mass="31223" checksum="CEE3B54ADB32E981" modified="2019-02-13" version="1">MSSDVRFTDFKSDKQPTWCPGCGDFGTMNGMMKGLAETGNDPDNTFVVAGIGCSGKIGTYMHSYALHGVHGRALPVGTGVKMARPDLEVMVAGGDGDGYSIGAGHFVHAVRRNVDMTYVVMDNRIYGLTKGQASPTSRSDFETSTTPEGPKQPPVNPLALALASGASFIAQSFSSDALRHQEIIQEAIEHDGFGFVNVFSPCVTFNDVDTYDYFRDSLADLEEEGHDPTDYEAAKEVILDGEKEYQGVMYQDENSVPYHEQHGVTEDMSDIPDGAPEDAMDLVREFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXB3</accession>
    <name>A0A3N6MXB3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS</fullName>
            <shortName evidence="1">tRNA(Ile2)-agm2C synthetase</shortName>
            <ecNumber evidence="1">6.3.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile2) agmatidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tiaS</name>
        <name evidence="3" type="ORF">EA462_09130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:43608"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10626"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83545"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TiaS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.22" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90142">
        <property type="protein sequence ID" value="RQG90142"/>
        <property type="gene ID" value="EA462_09130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01892">
        <property type="entry name" value="tRNA_Ile2_agm2C_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013696">
        <property type="entry name" value="DUF1743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024913">
        <property type="entry name" value="tRNA_Ile2__agm2C_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08489">
        <property type="entry name" value="DUF1743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUF1743" evidence="2">
        <location>
            <begin position="159"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="456" mass="49875" checksum="1052C4B2CB7ADA83" modified="2019-02-13" version="1">MTVVGLDDTDSREHGMCTTYVAASVAARLKREPSTTDQPNERGDEPRLCLVRLNPAVEYKTRGNAALAIHTDCDPDRAFAVARERLESLAVTGDERTNPGLVVADCPLEFASHEPTGSGSIPEDVVRFARRAVREHLEIDDAVSLIERHGYRSWSSGDGRGRIGALAAIGSWRGRSEWTYEHISYRNQNRWGTPRNVDVGSVFDAAEAGYPAAWDTVDRGENEPVCVPHTPGPILYGIRGDDPETVRKVARRIDGEPVASSQLFVTNQGTDAHLQDGAIADVRDGHAYRLEGRVASDPETRRGGHVFFDLVEPRNDADRSANSTAGVDGPILECAAFEPTKRFRDRIRALRTGDRITACGEVSRGTLKLEKVAVRGLVTTASVTPVCPDCERTMESAGRGQGYRCRDCGTTASKKSVIGVERDLENGWYEVPPCARRHIAKPLVRGGFDAPVHPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXF7</accession>
    <name>A0A3N6MXF7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA/HSCARG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90192">
        <property type="protein sequence ID" value="RQG90192"/>
        <property type="gene ID" value="EA462_09395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="300" mass="33193" checksum="AAD30172AEA14128" modified="2019-02-13" version="1">MTTSVLVTGATGNQGGSVVDHLLEAETEFDVSGLTRDASSEAARELADRGVSMVEGDLNDPDSFSEHVSDVDAVFVVTNFWTEGYEQQVEQGTNVADVASEVGIDHFVLSGVGSHERDTGVPHFDSAWEIERYATDLDLPMTVLQPVFFFQNLEAFAEDIVEDGRLELPLEEDVSLQMIDTDDVGRVAATVFERRDAFVGERLELAGDERTLTETAEVLSTVTGVDVEPVHVPIEDAYDTFGEEFTEMCEWFNEVGYSADIDALEDRFGFEYTDLETYLREHGWEDKDGMASVPGWVKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXR8</accession>
    <name>A0A3N6MXR8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_10125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90322">
        <property type="protein sequence ID" value="RQG90322"/>
        <property type="gene ID" value="EA462_10125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="235"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG90322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="41870" checksum="0327AB691675E652" modified="2019-02-13" version="1">MEFGLSDEQRQIRDEVTRFAENEIVPVAADHDENETYPYDVVESAAEMGLTGAYIPIDYGGAGYSILDTAIITEELFSYDPGIALSIVSTSFGCEAIMNFGTEDQKERFLEPVALGEKISGAAISEPDTGSDVSSVSTRAEKDGDEWVINGTKMWITNGSVGDFFVVLCETDPDAQGRYNGFSQIVVESDREGFSAEKITGKLGIRASDTAELVFDDVRVPEENLIGTRDAAFMQQMQFFDETRTAVAAQGVGIAKGAIRAALEYATDREQFGKSISEFQAIQHKLAEMATDTEAARNLTYKAAWKVDQGEDITKLASMAKEHASRVAVDVADEAVQIHGGAGYVNDFPVERLYRDAKITQIYEGTTEIQKNIIAREMLGKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXT2</accession>
    <name>A0A3N6MXT2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90342">
        <property type="protein sequence ID" value="RQG90342"/>
        <property type="gene ID" value="EA462_10230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="173" mass="18768" checksum="3794D1391DE165F1" modified="2019-02-13" version="1">MSSRTSALESPKASGDALEAHLIQSFDALEYVGDRTATWHDARTTTLLEPAESLPFYGIVVVEPGVPVEIKGCQIETSNGSGSTRGRFYVKREAHSRLLEAGGMYLFVVYIPRPGLPQVARAIVPATIVDELLSGRWYDVGGPRSENEVAKLAWSHVIDPETVDSSVTVGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0N9</accession>
    <name>A0A3N6N0N9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">ftsZ</name>
        <name evidence="10" type="ORF">EA462_05785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91472">
        <property type="protein sequence ID" value="RQG91472"/>
        <property type="gene ID" value="EA462_05785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 6 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="8">
        <location>
            <begin position="56"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="9">
        <location>
            <begin position="249"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG91472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="40110" checksum="E17AE34A2394DE5D" modified="2019-02-13" version="1">MDSLIDDAIDEAEDGDPSTVPDEAQSADGASSGSSRETGTMTDDELEDVLQDLQTDITVVGCGGAGGNTIDRMHEEGIHGAKLVAANTDVQHLVEIEADTKILMGEEKTGGRGAGSLPQVGEEAALESQQDIYDAIDGSDMVFVTAGLGGGTGTGSAPVVAKAAREAGALTISIVTTPFTAEGEVRRTNAEAGLERLRDVSDTVIVVPNDRLLDSVGKLPVRQAFKVSDEVLMRSVKGITELITKPGLVNLDFADVRTVMERGGVAMIGLGESDSEAKAEDSVKTALRSPLLDVDISGASSALVNVTGGNDMSIEEAEGVVEEIYDRIDPDARIIWGTSIDETLEGSMRTMIVVTGVQSPQIYGRPEGDAVQPEMEDDIDFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N174</accession>
    <name>A0A3N6N174_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="8">GGGP synthase</shortName>
            <shortName evidence="8">GGGPS</shortName>
            <ecNumber evidence="8">2.5.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">(S)-3-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoglycerol geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_04800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23404"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GGGP/HepGP synthase family. Group I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.41" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91702">
        <property type="protein sequence ID" value="RQG91702"/>
        <property type="gene ID" value="EA462_04800"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047294">
        <property type="term" value="F:phosphoglycerol geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002094">
        <property type="term" value="F:polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02812">
        <property type="entry name" value="PcrB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00112">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039074">
        <property type="entry name" value="GGGP/HepGP_synthase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038597">
        <property type="entry name" value="GGGP/HepGP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008205">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026417">
        <property type="entry name" value="GGGPS_Halobacteria"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40029">
        <property type="entry name" value="PTHR40029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01884">
        <property type="entry name" value="PcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01768">
        <property type="entry name" value="GGGP-family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04147">
        <property type="entry name" value="GGGPS_Halobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="8">
        <location>
            <begin position="162"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="8">
        <location>
            <begin position="212"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="233" mass="25105" checksum="B3A2BB7E76188583" modified="2019-02-13" version="1">MSPPWDDWNHVLKIDPDKELPPGTTYGDLCATGTDAIEVGGTMGITEANMEAVVEACSEHGVPLYQEPSSPDVVIDNEALEGYLIPTVFNAGSPFWITGAHKEWVRIDNGLDWERTATEAYIVMNPDADVATYTEADCDLDADEVAAYATVAERMFGQEIVYLEYSGTLGDEEIVAAASDATDEATLFYGGGIHDYESAYSMARYADVIVVGDLGHDEGVDAVRETVEAASDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3H5</accession>
    <name>A0A3N6N3H5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mgtE</name>
        <name evidence="9" type="ORF">EA462_00085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92672">
        <property type="protein sequence ID" value="RQG92672"/>
        <property type="gene ID" value="EA462_00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="85"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG92672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="345" mass="37253" checksum="9DA892BF92758BF8" modified="2019-02-13" version="1">MEVASSNLEFHADRVAEITDDEYVAVTQETFIGHAIDEFRDFDPITEETTVYYLYATDNAGRLVGVMSLRELLNAPEDDVVEDHMMTDLVTISADADPEHAADDMAERDFPALPVVDADGFLVGVLRTDDMLEVVEEEATEDILKSAGFSFADIEQSRSSAILESSIPRILRLRLPWLIVALAGGLLAGGVIEAYEDTLEAVVALAFFVPVIMDMGGNVGTQASTIFVRGLALGQIDDRNAMKYFAREGLIGLLIGLIIGGIGASAAYFWQIDEPYAFELATVVFVGLVSVCVVASVVGYVIPWVMNKLGFDPAAASDPLITTIKDVTALLIYFGLAAVLLAELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3L9</accession>
    <name>A0A3N6N3L9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1059 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92722">
        <property type="protein sequence ID" value="RQG92722"/>
        <property type="gene ID" value="EA462_00365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="57" mass="6704" checksum="55CAB5B814EF1C51" modified="2019-02-13" version="1">MVTERYRFRCHDVADCDVIVYSEFEESIYEAARSHLKDVHGRDVSDEDVAPYIEHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4M9</accession>
    <name>A0A3N6N4M9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-splicing endonuclease</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA-intron endonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">endA</name>
        <name evidence="5" type="ORF">EA462_02765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93142">
        <property type="protein sequence ID" value="RQG93142"/>
        <property type="gene ID" value="EA462_02765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01834">
        <property type="entry name" value="EndA_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023516">
        <property type="entry name" value="tRNA_splic_arch_long"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="PTHR21227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="SSF53032"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="SSF55267"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_int_endo_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_int_endo_N" evidence="4">
        <location>
            <begin position="184"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_int_endo" evidence="3">
        <location>
            <begin position="257"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="349" mass="38827" checksum="7A6C1FC8FE67B998" modified="2019-02-13" version="1">MSLEGRYDESANVVRLGENARQRFHDARGYGYPLSGNEIALAPVEAAHLLYRGDLEAVVDVESGERLSFRSFVAREPGTEFGVRFLVYADLRSRGFYLSPAAEPWLVDPPTADFAVFPRGKGPGDGEIAYTMRVIGERTDVPAADLASGVLAVVDEESEITYFDVGRADPRGSSTATLPDGCDADLLADRVVVWDPPLDLYEEAFYGQPLEGREYDRPTLQCSLLEAAFLVERGAIDLESSVVRERGREVEGERFGRRRRVYTALRERGVVPKTGYKFGADFRTYADVESVDELGHSELLVRVHSASAVFEPRDLALDVRLAHGVRKTMVFALVDGEEIEWWSLERLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N514</accession>
    <name>A0A3N6N514_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93302">
        <property type="protein sequence ID" value="RQG93302"/>
        <property type="gene ID" value="EA462_01905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="192" mass="21389" checksum="03A4EFF8CAB71727" modified="2019-02-13" version="1">MNLEPARTAVVVVDMQNGFCHPDGALYAPGSEAVIGPIASLLERAHDAGVTVLYTRDVHPPEQFEDAHYYDEFEQWGEHVLEGSWEAEIVEELPAESADHVVEKHTYDAFYETELEGWLNARGINDLVICGTLANVCVLHTGGSAGLRDFRPIMLEDCIGAIEDDHREYSLEHADWLFGEVAESDDLEFEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NU58</accession>
    <name>A0A3N6NU58_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86660">
        <property type="protein sequence ID" value="RQG86660"/>
        <property type="gene ID" value="EA462_16075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="79" mass="8594" checksum="21D2AEBEB276B2E6" modified="2019-02-13" version="1">MDEIDLDELVASLTPREENQTITVYQNTVAVSCPACDTQFDDLVVCKENPASLNLSKQLDLCVGSADGHAVIFTHKQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUA0</accession>
    <name>A0A3N6NUA0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86720">
        <property type="protein sequence ID" value="RQG86720"/>
        <property type="gene ID" value="EA462_16420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="287" mass="31209" checksum="C6986A9348BC72C4" modified="2019-02-13" version="1">MNPTPEDITLRGINYESDDGTEFDGFELTSDVSTFEGRNVGVLFLHGLRGFALGAGISPVAHPLARAGVRCLTINKRNSGKGYVTSDFAEIDRDIRGGVEWLLDQGCEDVVIWGRSLGATEAAYYQGKRNDDDVDGLVLAAPFADIRERSTRGYFEAISDEPDEAYESFVADARELVEDGRETEIVALPRPVGDDIEYIPMTAEAFLSYRSPESACATIDWVPKIDVPNLLVPHAADRNVTPAEAEEIADAYPGSTSVDVHPVEADHFFTGAESEVAGVTADFLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUD7</accession>
    <name>A0A3N6NUD7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86770">
        <property type="protein sequence ID" value="RQG86770"/>
        <property type="gene ID" value="EA462_16685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="144" mass="16156" checksum="96391D342978196D" modified="2019-02-13" version="1">MATTNPTAERTSTHVLEFDLGENRYCVDIGYVAEIVNTDELTEIPNTPDHIEGVMDLRGETAKIVNLRTIFGDEAGTTLGDRIIVFKRKRDSNERIGWLADEVHQVQELQTDIVDTSVNGSGIAGIVRREEEFVLWIDPTDVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUX4</accession>
    <name>A0A3N6NUX4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type IV pilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_15480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87040">
        <property type="protein sequence ID" value="RQG87040"/>
        <property type="gene ID" value="EA462_15480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012859">
        <property type="entry name" value="Pilin_N_archaeal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07790">
        <property type="entry name" value="Pilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Pilin_N" evidence="3">
        <location>
            <begin position="11"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="145" mass="15395" checksum="AF1F8AAF16B3722C" modified="2019-02-13" version="1">MTSHSLQYRNRAVSPVIGVILVVAITVILAAVVAGLVLDIGSDIDEEVQAGVSITVQHDPQYLDVQVTTLGNADHINITGDPYDNLDDSSPNNLDEDDLRELETGDSVRIGKDDLESAGENGTVVAVGVAGEQETLITSEDYNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVR0</accession>
    <name>A0A3N6NVR0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87962">
        <property type="protein sequence ID" value="RQG87962"/>
        <property type="gene ID" value="EA462_13965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="93"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="300" mass="31599" checksum="A50A5AA8391749AB" modified="2019-02-13" version="1">MNSETRTSTTDPSSPSKTGREIVVSELRYNPLTLVGVLLVTGIATVAIVGPLVTPYDPTAQNLANRLQSPSPIHPLGTDRLGRDVLTRLVYGARVSLGIALAVTTIRVVVGTGVGLLAGYVGGWVDELLMRLVDVQLAFPGLVLALVVAGILGPSLRNVMLALAVVGWATYARVVRATVLSVAEREYVEAAKLAGTPTSRIARRHLLPNVLGTVIVLATLNLGTVVLATAGLSFIGLGAQPPAPEWGTMIAGGRDYLRSAWWIVNAPGVAIVLTVLGFNLLGDGLRDVLDPRQRSQLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWF9</accession>
    <name>A0A3N6NWF9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88879">
        <property type="protein sequence ID" value="RQG88879"/>
        <property type="gene ID" value="EA462_10805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="83" mass="9024" checksum="6A0D4438E5E6AC63" modified="2019-02-13" version="1">MAGETDEDEIRVHPSATARDRTSIMIPSDSNSRTIAVARTGVRHLVRAIDAFSSGASCCRAERPLRRTAITKKAVCRRAGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX30</accession>
    <name>A0A3N6NX30_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_12545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89189">
        <property type="protein sequence ID" value="RQG89189"/>
        <property type="gene ID" value="EA462_12545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="204"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG89189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="437" mass="47205" checksum="979F05AB847507E9" modified="2019-02-13" version="1">MTTNSTDDATGTDAPTEATTDTADVDSALVTARRQLERAATHADVDSGVVERLKHPTRVQRVSVPLERDDGTVEVFTGYRSQHDDVRGPYKGGLRYHPHVNAEECIGLSMWMTWKCAVMDLPFGGGKGGIAVDPKALSADEIERLTRRFAEELRDIVGPTRDVPAPDMGTDAQTMAWFMDAYSMQQGETIPGVVTGKPPVIGGSFGREEAPGRSTAIITREAVDHYGRDLSETTVAIQGFGSVGANAARLLEDWGATVVSVSDVNGAIYDPDGLDVQSIPTHDEEPEAVLEQDAPETLSNDEILELDVDVLIPAAIGNVLTADNADDVGADLVVEGANGPTTFAADAIFEERGVPVIPDILANAGGVTVSYFEWLQDINRRQWTLEEVNDELESKMLDAWNDVRSEVESKDLSWRDAAYVVALSRIAEAKAVRGLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYY8</accession>
    <name>A0A3N6NYY8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90099">
        <property type="protein sequence ID" value="RQG90099"/>
        <property type="gene ID" value="EA462_08870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="63"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="316" mass="34743" checksum="A2B4B8AD95341B20" modified="2019-02-13" version="1">MNARTVLGVAAGIVGGAALSNRLLANRAGGLESRLPGVERNYRWRGIDIEYTVAGEPTDPDMLLLHGIHAGASSDEFEPVFERLADQYHVIAVDLPGFARSERPPLVYSPTLYADFVRDFASDVTDEPIVVASSLTGSFAVDAADETTFDSLVLICPTDETRDERPRLRSLLRTPLVGTTLYNALASKPSIEYFYDRDGYYDSDRLETETIDYAWRSAHQPGARYAPASFVAGSLDPDFDLATKLASLETPTTLVWGRDAELVSLRDGRDLAEAADLELVVIDYATQLPHVEHPEKFAEYLSAELVHSDLESGRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZB3</accession>
    <name>A0A3N6NZB3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RimK family alpha-L-glutamate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90269">
        <property type="protein sequence ID" value="RQG90269"/>
        <property type="gene ID" value="EA462_09835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008503">
        <property type="entry name" value="Put_Zn_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05618">
        <property type="entry name" value="Zn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="105"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="447" mass="47945" checksum="490D491CB79E6A75" modified="2019-02-13" version="1">MTGVDPVTVGVLSLHTSKETKAILNAVESLGHDTEWLRNENTSVSVEDGTVSLEPSVDVIANRMLLSNTEQPAEELGLANTFKQLVPMLNEPASVLTAIHKLSTATTLSANDVRTPDVTLSLNSERLNAVRDRYGEEAVYKTAIGTHGGGTWKVGPNEPVNAKVGNRYAFLQELIDRDDSRHRDVRVYVVGGEIIAAMYRYAPDNDWRTNVALGGSVEDATEDLPEEVRDLARRAADAVDLDYAGVDLVESNDGWFVLEVNPTAGFKGLYEATHISPAPHIAKLAIERGGGEVDEERVAELSNVLDDSQPTAQPVQTSAGTEETAVIGYTEDVVLSGTSGSKSVLAKSDTGATRTSIDTALAADIGAGPIKSITRIRSGSSKTAKSRPVVDVVVGVGGNQHTVTASVEDRGHMDYPVLLGRDILENYRVDVSRRTDRDASDTPEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZE0</accession>
    <name>A0A3N6NZE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90309">
        <property type="protein sequence ID" value="RQG90309"/>
        <property type="gene ID" value="EA462_10050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="256" mass="27864" checksum="584D68BE03DC4856" modified="2019-02-13" version="1">MVDENDELTEAIRELTRTIDDLSREFEPQPRRPPLRPPTPRELLAFTDEVALPAMLAVLNSSVRTLETFQRGLELVRTEREVRERTGEVVSSERANDLRKTTLSRLDTVLAELQRAASEGTLPADERARELLTDARRLRDDVDDRLEDAAGGLDPDERDGSPSSESVEIDIDEGSSGADQRSVDGDAESNVDVDAELETLKDQYGPDDDPDSSSVGDDVSGDDAGNSAEQGDRSADHGGSDDSGGENAGEHSDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZJ2</accession>
    <name>A0A3N6NZJ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_10075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90389">
        <property type="protein sequence ID" value="RQG90389"/>
        <property type="gene ID" value="EA462_10075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="170"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG90389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="418" mass="45807" checksum="5355DE4544BEE4A3" modified="2019-02-13" version="1">MARQTDIHETVAMASEPSNPFTDLPLNEWRDVFFSLPEEVQEHLIVDMSRSELETFIDRLDPDEVTAVLWFTDEETREALLTTLDSERREKIDFLLSFNPESAAGVMSLDYVTVDEARGFPEVIERVRRFEDRMGQVPTIFVTDDEELQGELPGAALSVADEEAETINDYVQETPHIRYDRDDEEVLEVFKQNRERSVAVLDEDEDILGVIHAEDLFRMLEEARGETLYEFTGVAEEESVLDGPGTKVRRRYKWLILNLGTAFMAAAVVGLFESTIAAVAILAAYMPVVAGMGGNAGTQAMAVTVRGISLGEVSLNTGKRVIFNEVAAGAVNGMITGVLVAVIAIAFSFGEFGLLLGAVIGISMVANLVIAGFFGAITPLLLDRIGYDPATSATIFITTATDVLGFFVFLGLAQAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0J1</accession>
    <name>A0A3N6P0J1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88008">
        <property type="protein sequence ID" value="RQG88008"/>
        <property type="gene ID" value="EA462_14215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="110" mass="12225" checksum="5D6BDB2A192CE673" modified="2019-02-13" version="1">MVHPDATPPVVPDPSSESVRTGTTRSEPTVSDPPQPTGAIEESAAYPGATNEPRQPRDDASLVQPRRRDGVNQVDLEAVLQSRGLIDDLVEKIYRKTERKRQIDRERRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0N1</accession>
    <name>A0A3N6P0N1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase family protein molybdopterin-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88068">
        <property type="protein sequence ID" value="RQG88068"/>
        <property type="gene ID" value="EA462_14560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="803" mass="86391" checksum="66B85989B036F098" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0Z5</accession>
    <name>A0A3N6P0Z5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91149">
        <property type="protein sequence ID" value="RQG91149"/>
        <property type="gene ID" value="EA462_03905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043870">
        <property type="entry name" value="DUF5830"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19148">
        <property type="entry name" value="DUF5830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="140" mass="15994" checksum="EA4B3F9A5FB683E1" modified="2019-02-13" version="1">MDREGNDRRERRNDRTNREERAHLDDRVRLGLALLERLEHESLSLADVVDRIETVTADPTVTRTILDEAELRGIVERDDGIVRPKSRQYVRFGRDVITKEGEFSCRRCGSSLSTGYFIDLEAGELGPFGSSCVRKVTGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1D5</accession>
    <name>A0A3N6P1D5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EA462_04745</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91299">
        <property type="protein sequence ID" value="RQG91299"/>
        <property type="gene ID" value="EA462_04745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="PTHR10887:SF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dna2" evidence="13">
        <location>
            <begin position="55"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_11" evidence="14">
        <location>
            <begin position="533"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_11" evidence="14">
        <location>
            <begin position="637"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="15">
        <location>
            <begin position="725"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RQG91299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="936" mass="103161" checksum="B40E9BAB9D4AF37D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1K1</accession>
    <name>A0A3N6P1K1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88965">
        <property type="protein sequence ID" value="RQG88965"/>
        <property type="gene ID" value="EA462_11285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="91" mass="10974" checksum="669CCED8FA878ABF" modified="2019-02-13" version="1">MYDLTGFQRDLLYVIAGEEEPHGLAIKEELEQYYEKEIHHGRLYPNLDTLVDKGLVEKGTRDRRTNFYTLTRRGRRELEARREWEAQYVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3I6</accession>
    <name>A0A3N6P3I6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89855">
        <property type="protein sequence ID" value="RQG89855"/>
        <property type="gene ID" value="EA462_07520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="203" mass="22452" checksum="03B2A4EE7321066B" modified="2019-02-13" version="1">MTEDDPDVSDDRFDESNDDHWLSSLLAALESLERRSASDVDRRGRSTVEYDLSIRTLDDLLDSGSAFGGDPVASEGFDQRDPAVNDGSDERTNDHRRRRRRRSRSSRSYHLTTRRYDDELVISADVTSADPGEVTVGLDDDAIVIAVDTREIGRVNVPWPEHTTEAAVRNGVLTVRIEPESSAGSAASGTEVDPNEDTEDTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4N4</accession>
    <name>A0A3N6P4N4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92939">
        <property type="protein sequence ID" value="RQG92939"/>
        <property type="gene ID" value="EA462_01595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="248" mass="27061" checksum="8A194A9E57410923" modified="2019-02-13" version="1">MDADGDSSSTCDHDRTGNHDDVLSELLSGNQRHVEDLSNDYFSSVRTGQHPEAVSVCCSDSRVPQERMWGVEDPGTVFTPSNIGNQVWDDDGDDRIVDGGLLYPIHHAETEVATVVGHTGCGAVTAAYRVATGGSKPGPRGVDKWVDMLVPVVEDGLESDLIDASEDEETVINQLVEYNVDRQATFLRESPDVPDDVDVYGFVYDFQGIYGDDDGRAYLVNLNGETTPDAIAARLPEEYEAVTRSLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4P3</accession>
    <name>A0A3N6P4P3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92959">
        <property type="protein sequence ID" value="RQG92959"/>
        <property type="gene ID" value="EA462_01710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="88" mass="9577" checksum="03DFD532A6734E6C" modified="2019-02-13" version="1">MSNHSPLPNESIGPSSPDADPQGEGRPLRRSLKGPAQFLSFWVAIALPFVHVPLLSRGLGDPRVTLAFFTLLVLNVLALYVGHGYNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4Z7</accession>
    <name>A0A3N6P4Z7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 19" type="primary">uvrB</name>
        <name evidence="19" type="ORF">EA462_02530</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93099">
        <property type="protein sequence ID" value="RQG93099"/>
        <property type="gene ID" value="EA462_02530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="40"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="443"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="16">
        <location>
            <begin position="632"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="588"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RQG93099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="684" mass="77633" checksum="C8C40139B6F22B0E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P517</accession>
    <name>A0A3N6P517_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF309 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93129">
        <property type="protein sequence ID" value="RQG93129"/>
        <property type="gene ID" value="EA462_02690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="204" mass="23278" checksum="A8277E1D987FF40D" modified="2019-02-13" version="1">MRDQLRAGVAIYNDGFYHAAHDAWEERWLDLEAGTDDERLLHGLIQFTAAVFHARNRNWEGAVGLAESACEYLAELPDGYRDLWLPPVRSFLETLATDPDVIERREPPAIDHDGDTPTLTDLGLEATAIAAVVLAEELGYGDEPLEHALTYARRDLEDGIDDSRFISLLFEFVREDDHRGIVYQRLTEHVDRRRSREEDVDGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6C4</accession>
    <name>A0A3N6P6C4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3225 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91295">
        <property type="protein sequence ID" value="RQG91295"/>
        <property type="gene ID" value="EA462_04725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="140" mass="15814" checksum="B5C11226A8107DE5" modified="2019-02-13" version="1">MSTSAVDIVSDYYDALRRGDPLEPYFLEGDSTVKFGISEALFGYESVADALREQTATTTDWRLESHRLVVRDGGEFATFADDVTMAWRDTESGDDREFETRWSGALVRTDGDRHTENDVDRDVPDWSFVTMHVSTGSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6N7</accession>
    <name>A0A3N6P6N7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91525">
        <property type="protein sequence ID" value="RQG91525"/>
        <property type="gene ID" value="EA462_06070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="81" mass="8737" checksum="F7BE441DE50A2188" modified="2019-02-13" version="1">MTAHLGTHDVQMSSSDTGAISRCEKLEDPFNDARFDPMFTVIFLGLMLVAAVLKGIGRSFILSINEIAPVDGSVANLQLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P717</accession>
    <name>A0A3N6P717_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91705">
        <property type="protein sequence ID" value="RQG91705"/>
        <property type="gene ID" value="EA462_04850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043900">
        <property type="entry name" value="DUF5788"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19101">
        <property type="entry name" value="DUF5788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="146" mass="16976" checksum="39A396CCCF9ED0B5" modified="2019-02-13" version="1">MQEYERKQLLERVERESATVGADIPETITVQGEEIDLRTFVFEIKRRETVPPGERDRVERAKRNLRRERTDRLERIEDGPISREEGETLARDVIGIDRALNALENLGQTDLEREQQTQQAADTKRWMSFLEKALGRADDAGARRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9A2</accession>
    <name>A0A3N6P9A2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF58 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_00720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92785">
        <property type="protein sequence ID" value="RQG92785"/>
        <property type="gene ID" value="EA462_00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="3">
        <location>
            <begin position="223"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="397" mass="42680" checksum="12A31B73C38193FA" modified="2019-02-13" version="1">MESGRTTGRVTAIEWSKRPSSASRSRRSGCSPGDPPVRLTLRGWVVVAVIAFSLWTSARYGPRSLNAVVVPATIVVLAGVVSVARISRPSVERTTSSEGVAGDGLTIEHVIDGDRTVSATLSEAADGELYDVKSDGDPTTETVLEAGVQTRFEYELHLEKRGTDVIGPLSIVVTDVFGLVARRFDDDGTTSLVVVPPTKELRAGPTERLLAPAVESDRDERAEFDHLREYRRGDSLRDVHWKSTAKRADDGLFVTEYVAEGDAGSVTIALECVEGRADELATAAASVADSLLERGVRVGLVRSDGGAPLAPGTGREHRRDVLEILAVVDSGELAVDTRREADVRIRADESETTVSVGDVETSFERLRRGRDHGREFGPTVDETRSDDPGMDDFGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHI1</accession>
    <name>A0A3N6LHI1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Triphosphoribosyl-dephospho-CoA synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86150">
        <property type="protein sequence ID" value="RQG86150"/>
        <property type="gene ID" value="EA462_16900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046917">
        <property type="term" value="F:triphosphoribosyl-dephospho-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002736">
        <property type="entry name" value="CitG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01874">
        <property type="entry name" value="CitG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="283" mass="30640" checksum="0DF2AC440B0FA6E6" modified="2019-02-13" version="1">MRTPAQNAQLALLLEVAGTPKPGNVDRRRDLDDLRFEHFLAGAVGAQRGLEMAANGAAVGRSFEVAIEGMSDQRGDNTQFGALLLTVPLVRAAREELSPSAVESVVEGTTVDDAAAFYRAFEHVDVFVSDPPEEMESLDVRRGRDAVPTLEDRSLTLFDVLERSVPGDDVAREWVYGFERSFLASELLATANGTPLDRTAAVFLSLLAERPDTLIAKRHGDAVAREVTDRASELLDRDALETEPEAVETFADELVERGVNPGTTADVTAAGLFIALECETLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHL9</accession>
    <name>A0A3N6LHL9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86644">
        <property type="protein sequence ID" value="RQG86644"/>
        <property type="gene ID" value="EA462_15965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="390" mass="40687" checksum="C62F9036618847F6" modified="2019-02-13" version="1">MNWQYRYSVLVLCTLAFFVTYFARLAVSPVVPFIIDDFEISNTLIGVALSGMWLAYGLAQFPSGILSDRYGEKPIILIAVGGTAVVSVLLALSPVFGAFVVAAVVLGGVAGLHYSVASALLSVTFDDLGTAIGIHSIGGPLAGLVAPVAAAWVGVRYGWRPAIALTAVVGVPIFVLVLLWIRPTEPRQPDKPLRDSLELRTVVELISRPAIAFPLLIAIAGTYVVQGLLSFFPAFLVAFHEYSPTAAGVAFSAFFLVRTVSQIVLGRASDAYGRDIAIAGSMMAGAVGVPLVILDSGTVTMAAGITLVAVASSFFAVIDPRFMDALSVEERGSGFGLVRTVYTVVGAAGSVGVGLTADLFGWGVAFGTLAALFAISFLSVVVNRMLGLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI08</accession>
    <name>A0A3N6LI08_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_16355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86709">
        <property type="protein sequence ID" value="RQG86709"/>
        <property type="gene ID" value="EA462_16355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="244" mass="27000" checksum="F382D5D2B1DED8B1" modified="2019-02-13" version="1">MVMGTTTLLRIEEVHKTFGGIVALDQFTATVNEDEITGLIGPNGAGKTTLFNVITGVLTPDSGSIRFEGKELTSLKSHQICHEGIGRTFQTPKPVRSLTVRENLQVARKYGVGDNEKRETIQSINEVIELFSLEEKQDTITKELQLVEQKFVDVARALVTGPKLILLDEIMAGLNPTEKQEMMSTIKTINTEFGSTFLIIEHDLGIIRSISDRIITIHEGSELTSGSPEKVMENDKVREAYIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI91</accession>
    <name>A0A3N6LI91_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87034">
        <property type="protein sequence ID" value="RQG87034"/>
        <property type="gene ID" value="EA462_15450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="77" mass="8294" checksum="6CDFEEDC5E9C522B" modified="2019-02-13" version="1">MCTAPIESVESVSFAVVMAVAQRKGTPVKELRPLHDVVDPDALDALCTAAEVSVTFSYDGYMVTINGDESIHLEEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIN4</accession>
    <name>A0A3N6LIN4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="7">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_15845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87099">
        <property type="protein sequence ID" value="RQG87099"/>
        <property type="gene ID" value="EA462_15845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="5">
        <location>
            <begin position="39"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="6">
        <location>
            <begin position="301"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="551" mass="62659" checksum="2A02A314F21C7B23" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIP7</accession>
    <name>A0A3N6LIP7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS1595 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10245</name>
        <name evidence="1" type="ORF">EA462_14670</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87119">
        <property type="protein sequence ID" value="RQG87119"/>
        <property type="gene ID" value="EA462_14670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90391">
        <property type="protein sequence ID" value="RQG90391"/>
        <property type="gene ID" value="EA462_10245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="32" mass="3754" checksum="C7860B37EA5C241E" modified="2019-02-13" version="1" fragment="single">KLTPYLRAFQLRRELYRKPGDEALKHAIDAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIR0</accession>
    <name>A0A3N6LIR0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87139">
        <property type="protein sequence ID" value="RQG87139"/>
        <property type="gene ID" value="EA462_15595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="114" mass="12445" checksum="82BF2ED6BD19784C" modified="2019-02-13" version="1">MSVIQATDTQLPSDYLLLLSASLIALGLALFIVFHAYRGYQRNSSVRMLYLACGLGLITVVPMTLSIGVNSLGQMVDLAPRVYTFYLPLATRVSEITGICTLLYSLLIKPSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIZ7</accession>
    <name>A0A3N6LIZ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-acylating methylmalonate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87781">
        <property type="protein sequence ID" value="RQG87781"/>
        <property type="gene ID" value="EA462_12975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="29"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="497" mass="53670" checksum="F920D2841F89A604" modified="2019-02-13" version="1">MAGQEQTQLTASVPDVAQNYVGGEWTVPADGEEHSLENPATGDSIATVHYASANDVETVVDTAADAFDDWRRTPPVERIQYLFDLKAELEDRQEDIAQALTREHGKTLSEARGEVRRGIENVEVASGIPNMFREQSGNVEDVASGVDERSVREPLGVFTAIVPFNFPAMIPLWFLPYAVATGNTFVLKPSERVPLSSQIIFDAVDAAGFPDGVVNLVNGDAEAVNALMEHPEVAGVSFVGSSPVAKYVYETAAQEGKRVQAQGGAKNYAVVTESASLSEAVPNIIGSVYGNAGQRCLANDVVVGVGDVYDDLREQLIDGAESLTVGYGIDEETDVGPLITGDSRERVLDLIDDALEEGAELVLDGRDYEHPEYDGHFLGPTFLEGVTTDMEITQTEIFGPVLCLADASDLGEAIEMVNSTRYGNASSIYTERGGEARTYRYEVDAGNIGVNVGVCAPMGFFHFGGRKDSFFGDLHAQGEDAVNFYTEKTILIERWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJM1</accession>
    <name>A0A3N6LJM1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_11045</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88923">
        <property type="protein sequence ID" value="RQG88923"/>
        <property type="gene ID" value="EA462_11045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG88923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="558" mass="61013" checksum="1F73D1BB69EE465B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK23</accession>
    <name>A0A3N6LK23_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86708">
        <property type="protein sequence ID" value="RQG86708"/>
        <property type="gene ID" value="EA462_16350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="35"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="386" mass="42517" checksum="184AE50CB2CEFBF2" modified="2019-02-13" version="1">MTNNSTRRRFVISTGALGAAAIAGCVGDDEVQRAIGAATPQSGPLEPDGTAGIRGMEVAIEELTEELDEPIELQATDGEAAPDRAVSVARNMYDNNIPVITGTFSSDVSNVLSDLAEDEEVPFITSISVDPEIINEDDEYTFRMTGDTTQKLKGMAEFLEEEGVSGIAVIAADYSMGESSIEFFEERAEEYGMELVHSAEVPMETDNFVPEIGDLDTDEIDALFYPFPGGTAPTLISQTREQGLFDEVDIVIGHDSYGTETFYESLGDDLQDMYFWGVDLENEQAQQANERMQEMFDVRMDPLSLPYYDTIHLIAEVMGEQGSVDPQDIRNGLADIEYETASGWDVRFDQNGNNTEFQMIVGQWQEDDDGELAPNVEYTSHVVSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK67</accession>
    <name>A0A3N6LK67_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">30S ribosomal protein S27e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps27e</name>
        <name evidence="5" type="ORF">EA462_11300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3 4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88968">
        <property type="protein sequence ID" value="RQG88968"/>
        <property type="gene ID" value="EA462_11300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_S27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_S27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG88968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="57" mass="6098" checksum="A005D99FAC4404E0" modified="2019-02-13" version="1">MAGNFYSVRCSDCENEQTVFGKASTEVACAVCGTTLARPTGGKAEIEHEIIETVESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKE3</accession>
    <name>A0A3N6LKE3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable ribonuclease FAU-1</fullName>
            <ecNumber evidence="6">3.1.26.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA-binding protein FAU-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fau-1</name>
        <name evidence="8" type="ORF">EA462_12050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FAU-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89098">
        <property type="protein sequence ID" value="RQG89098"/>
        <property type="gene ID" value="EA462_12050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:endoribonuclease activity, producing 5'-phosphomonoesters"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01910">
        <property type="entry name" value="RNA_binding_AU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016730">
        <property type="entry name" value="RNA-bd_FAU-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018644">
        <property type="entry name" value="RNA-binding_FAU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DUF402" evidence="7">
        <location>
            <begin position="384"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="480" mass="52472" checksum="4BC49C7E9A7642FB" modified="2019-02-13" version="1">MTTVRIRGIYATAITRLLEQRGFEIAQASEPIRDRFDESFATAPADVTIDTTRDRQGLELSGVPEEVEAVATALEDVSIDTFRWADDVPRGAVFDAEVVAASGGSGAVVDLGDDRRGYLPYDAVDGYVDDGSRYRLQVHEPAPPWDDDRPLVEPTLEARGDLCTLSRDRHGVSAAVRGARGDELVGMTDLLSIDRPEGWGVRWQPPAAEADLETMTTALERGVERVRTLEDGLADAPGEPDEPDRLLAPGETEWIWFGRESRFELDDVRRDVETTMPGHHRTKAADRAASAAVDFTESVTASIASDGAFPSADSFPFETVARQFGPTVDDRLEIGHGKPDGRLVSLGRGEVTDWGPDGTLTLERSMRGGGTYDALDVPKEDGDVAVTKFREGRWWYPTTYRTADGSTKGTYVNVCTPVELFPERIRYVDLYVDVIKRADGTVEVVDGDELEAAVDDGLVSEELSERARSVAAAVERAFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKH6</accession>
    <name>A0A3N6LKH6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNB domain-containing ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86938">
        <property type="protein sequence ID" value="RQG86938"/>
        <property type="gene ID" value="EA462_14870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="71"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="426" mass="49019" checksum="49C320120A652BB9" modified="2019-02-13" version="1">MSDDAQAEAGTAEGQGPVEISEELSRHLENKREELFEKFEIRDGFPAEVLDEAEARTENVQSEITDEIDERRDLRDLTTWTTDPIDAQDFDDAISVEERDDEYVLWVHIADVAHYVHPESSMWTEAVERGNTVYLPGYTVHMLPPVLAESVCSLVPNEERFAHTVEMHLDRETLSYETIDIYKSVIESDERLTYSQAENRLDDPDAPLHEENVLVHDLADQMHEQRKEDGSLVLNPSRDRAHTIIEECMLKANKAVTHELMWNRGVEAMYRVHPQPSPDEWSKALQEIQDLDGVSIPGDTWEDPRKAVNATLEEAPSRQLDKIQWAVMKVMPRARYMNDPFGGHHALNFEIYGHFTSPIRRLSDLINHWIVYQNDVPENLVALCDRASDKQKDAEQCEREYKSFLQEVDLDPMAVNNRGIEVVDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKL8</accession>
    <name>A0A3N6LKL8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">katG</name>
        <name evidence="12" type="ORF">EA462_12645</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89208">
        <property type="protein sequence ID" value="RQG89208"/>
        <property type="gene ID" value="EA462_12645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="111"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-77)" evidence="8">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG89208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="714" mass="79776" checksum="923584D381F5BD44" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLR7</accession>
    <name>A0A3N6LLR7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89838">
        <property type="protein sequence ID" value="RQG89838"/>
        <property type="gene ID" value="EA462_07415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="320" mass="34424" checksum="F04B7E0F90E273C7" modified="2019-02-13" version="1">MADVRGRDAPRRDEDGSVHRGQLLLVMGVMIALTLVFLAVLLNSVIYAENLGTRGSDIGGNDAVQFESAVQDAGEGFVTATNRDADSQDHDPLVSEFDESIADWDDLSRSHLVRDGHYASLSFDRTPSSPSNGSQIRQSESGSFQNANDESAWAVVENADVRNYSMTIHDVSDDFLLSVSTADGEWNLTVGDGSETTVTTERDGNVIADCTVHDEPFEIDFVAGTVDGDYCNGEPVTFAGDLEAPYGTIEYANASAVEGTYTLTVNSTDPLSSNSFNQPGEDEPVAVAGIYAADVSLMYETERIEYESTVTAAPNTHYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLU4</accession>
    <name>A0A3N6LLU4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89878">
        <property type="protein sequence ID" value="RQG89878"/>
        <property type="gene ID" value="EA462_07640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="193" mass="22021" checksum="FE65A805E711E690" modified="2019-02-13" version="1">MSTEESRHVYRLHSTLELPLEELRDHIDDATFPEGVDDVEITRRNNTLILKAVANDETVSKYTPSAQLKASVTENRVYEEDPDERRNSFHWDEEEEEEIESELVEFAAFKGDRETVLQNSLLQYEMFLVLCEIAENTEKGTLTAISEHGGELEATRIVEGEPRPANIEVVEGPRDHGSGESGVNWRDNKFISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLV4</accession>
    <name>A0A3N6LLV4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="6">IMP dehydrogenase</shortName>
            <shortName evidence="6">IMPD</shortName>
            <shortName evidence="6">IMPDH</shortName>
            <ecNumber evidence="6 13">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 16" type="primary">guaB</name>
        <name evidence="16" type="ORF">EA462_07710</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 13">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 13">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 12">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="6 13"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89888">
        <property type="protein sequence ID" value="RQG89888"/>
        <property type="gene ID" value="EA462_07710"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 13" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="6 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="105"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="169"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="6 8">
        <location>
            <begin position="348"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="6 8">
        <location>
            <begin position="371"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="6 8">
        <location>
            <begin position="395"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="6 7">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <begin position="308"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RQG89888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="499" mass="53203" checksum="0481DC798F89269A" modified="2019-02-13" version="1">MANDVPEHGSYSSKLDVPEALTFDDVLLRPKESRVEPDDADLTSRVSKTVEVSVPILSAAMDTVTESGMATAMARHGGLGVLHRNMNIDEMVEEIERVKTADELIIPLDSVVTADPEMSVREVDDLMAREGVGGAPVVNTRGEVLGIISSTDIRPHLEVNEDDPVTEAMTDEVITVHEDVDARDAFDLMYDHKIERVPVVDDENLLVGLVTMQGILQRREYKEAVRDEDGRLRLGVAVSPFELDRAEAADNADADVLFIDTAHAHNRNVIEGAREIKAAVEADVVVGNVGTREAAADLVDFADGIKVGIGPGSICTTRVVSGSGMPQITAVAQVADVASEHGVPVIADGGIRYSGDAIKAIAAGADAVMLGSYFAGTDEAPGRVVTMNGKKYKQYRGMGSVGAMKSGDSDRYLKEEPDDDEYVPEGVEAATPFKGTLRSELHQLAGGMQSGMGYVGAGTIPEFKTRSEFVRVSSAGQAESHAHDVVITDEAPNYSPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLY4</accession>
    <name>A0A3N6LLY4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90063">
        <property type="protein sequence ID" value="RQG90063"/>
        <property type="gene ID" value="EA462_08670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="85"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="537" mass="60405" checksum="570236C146DDC403" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM06</accession>
    <name>A0A3N6LM06_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor S</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Transcription elongation factor IIS/RNA polymerase subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_08200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89978">
        <property type="protein sequence ID" value="RQG89978"/>
        <property type="gene ID" value="EA462_08200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006288">
        <property type="entry name" value="TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01384">
        <property type="entry name" value="TFS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG89978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="109" mass="12347" checksum="EC2BB5EF9FBE9D28" modified="2019-02-13" version="1">MQFCDDCGSMMKASGERMICTNDDCGASTERNRDREDEFVTTESQTDGDVIESSEDANFEGKPKASDVVCDECGNQEAWYTLKQTASADEPPTRFFKCTECGHRWREYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMM1</accession>
    <name>A0A3N6LMM1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Archaemetzincin</fullName>
            <ecNumber evidence="1">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">amzA</name>
        <name evidence="2" type="ORF">EA462_11915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable zinc metalloprotease whose natural substrate is unknown.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89077">
        <property type="protein sequence ID" value="RQG89077"/>
        <property type="gene ID" value="EA462_11915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11375">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01842">
        <property type="entry name" value="Archaemetzincin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012091">
        <property type="entry name" value="Pept_M54_archaemetzncn_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910">
        <property type="entry name" value="PTHR15910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005785">
        <property type="entry name" value="Zn-prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="173" mass="19235" checksum="C1C7EB597A1920B6" modified="2019-02-13" version="1">MLVDIVPVGNVSAEVKRAASSALRSVYDCDVSINDSQSVPNGAYDSGRNQYSAETFIQLAERIGRGTKNIAITPHDLFYRRRNYVFGLAYLDGSGSVVSTYRLQTSSDGGFSNKSASEIFENRVRKEIVHEIGHTYGLEHCDNNRCVMNFSPTVREVDIKEEHLCGSCQRIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMP6</accession>
    <name>A0A3N6LMP6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90368">
        <property type="protein sequence ID" value="RQG90368"/>
        <property type="gene ID" value="EA462_08800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="149" mass="16288" checksum="20143ED56D484209" modified="2019-02-13" version="1">MNSRIEAPIDILLVEDNPGDARLTEEAFEAHSNEVTLSVTTSGDEALEVLRKRRDEDPATVPDLVLLDLNMPGMDGFEFLRTIKADSAFTRLPVLVLTSSTASEDVLESYELAANAYLTKPTDPDEYAAIADAVVAFWFERASLPSSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMT7</accession>
    <name>A0A3N6LMT7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89177">
        <property type="protein sequence ID" value="RQG89177"/>
        <property type="gene ID" value="EA462_12485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025707">
        <property type="entry name" value="DNA_bp_PD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016702">
        <property type="entry name" value="DNA_bp_PD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="139" mass="15580" checksum="9602CCBA8BD8CCD6" modified="2019-02-13" version="1">MNYRAVETTGEYVARLETGADWRAEIESLAAAVEADAAWFSALGAVQDAECWFYDQDDCEYDAIEFDEPLEVASCVGNVSWLDGDRFAHTHAVLSDPEGNAVAGHLNEATVWAGEVYMRVFEEALEREYDETTELDLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMZ5</accession>
    <name>A0A3N6LMZ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89287">
        <property type="protein sequence ID" value="RQG89287"/>
        <property type="gene ID" value="EA462_11985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HELICc2" evidence="2">
        <location>
            <begin position="399"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="606" mass="67788" checksum="420386CCB58CDC16" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPH5</accession>
    <name>A0A3N6LPH5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03557 family F420-dependent LLM class oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90047">
        <property type="protein sequence ID" value="RQG90047"/>
        <property type="gene ID" value="EA462_08585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023907">
        <property type="entry name" value="Non-F420_Flavin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03885">
        <property type="entry name" value="flavin_revert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="321" mass="36330" checksum="DDC29D763FE8C67C" modified="2019-02-13" version="1">MTNIGYHASHEQFAPSKLLEFVTLADEYGFDDVLASDHFHPWSERQGESGFVWSWLGSAMEATTMTFGTVNAPGYRYHPAIVAQAAATLRETYPERFWLAVGSGQLLNEGITGGNWPTKADRNERLEESARVIRRLWDGEDVTHDGRIDVERATLYTRPETSPPLVGAALSEETAGWLGACEWTDGLITIATPDHEGLERRIDAFRENAPDEPVFLKVQLSYATDEETALDGAYDQWRTNCIPGSVTQELRTPEQYDELAERTSREHVRENVRVSADLDRHLEWLHEDLSLDVDKLVLHNVNREQTRFVEDFGETVIPALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPV3</accession>
    <name>A0A3N6LPV3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90227">
        <property type="protein sequence ID" value="RQG90227"/>
        <property type="gene ID" value="EA462_09590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="396" mass="43455" checksum="BB1C84FDFD9790F2" modified="2019-02-13" version="1">MHSVDDLSDAIDVTRDLLLPIRAKLWLKLAIVVFFVGGMGMGGGVPTGDVSMFGDDVPVDGVDEGVDAIPEDVLLIVGAVLLVLLALWLLFQVLAAIMEFVFIESLRSKEVHIRRYVRANLGRGLRLFGFRLLIGLFAFAVVAVPTVLVVLNASSTEAILGSVLLLLLVGVVVYLGYAVVMRFTSEFVAPIMLLESRGVLSGWSRFLSTFKANWSEYVVYLILVWILQLVVSFAAGILILFAIIVIAIPFVIVIFGLLTLGELGLWLAVPVGIVAGLIMLLVVALIETPIRSYFQYYALLILGDTDAELDLIPEQRAAVRGDGGAPIDRDEPAHDDDRWDGDESDDTATWDDTDSDSSSYWDDPDTGSDWDDSDGGSDRDDRDDRDDRDDRDDRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPX1</accession>
    <name>A0A3N6LPX1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trm112 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90257">
        <property type="protein sequence ID" value="RQG90257"/>
        <property type="gene ID" value="EA462_09765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="66" mass="7462" checksum="569422E2AA12C4C0" modified="2019-02-13" version="1">MKESLLDILRCPMDKHELELEDAEYGENGDEIVAGTLVCVECGERYRIEDGIPNLLPPDMREETPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ57</accession>
    <name>A0A3N6LQ57_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class IV adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cyaB</name>
        <name evidence="2" type="ORF">EA462_04360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91693">
        <property type="protein sequence ID" value="RQG91693"/>
        <property type="gene ID" value="EA462_04360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="PTHR21028"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00318">
        <property type="entry name" value="cyaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="205" mass="22786" checksum="552A84F52F73D99E" modified="2019-02-13" version="1">MYEVEVKVPADLASVRSRLEELEVASDGTVVQTDSYYDAPHRSFPDTDEALRIRTERPTEGTNETRLTYKGPLVDDESKTRKELETTVASRETVAGILTNLGFEAAATVRKERERFVIRLVDVLETPADATPDTTTFDATTSDREYTITLDTVDGVGEFLEVETDVEAETDLEPARDGAYAVLELIGLDPTNQIRTSYLELSLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQD3</accession>
    <name>A0A3N6LQD3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="5 10">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EA462_12415</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + NAD(+) = 2-dehydropantoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:61292"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:61294"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:16235"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="5 10"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89164">
        <property type="protein sequence ID" value="RQG89164"/>
        <property type="gene ID" value="EA462_12415"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="11">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="12">
        <location>
            <begin position="173"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG89164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="299" mass="31104" checksum="1BD15F24050AF768" modified="2019-02-13" version="1">MEIVVFGAGSLGSLVGGRLARDHEVTLVARAEHTEAIRDSGLHIEGELEATVFPAATTDGRGLAADLAIVTVKSGDTATAADALATGSFDVVLSLQNGMGNEAVLADVLEGSILAGTASYGAVRREPGTVECTGRGEIVLGAREGGSSVLAERVGRAFSVVGLETTVADDMPRRLWGKLAVNAGINPVTALADVENGAVLDPPANDTARAATRETARVARACGVHLPNRVALESMARVADDTAANASSMRQDVRTGRRTEIDAINGYVLDRASERGLEVPTNRTLATLVRTWERARGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS45</accession>
    <name>A0A3N6LS45_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92683">
        <property type="protein sequence ID" value="RQG92683"/>
        <property type="gene ID" value="EA462_00145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="134" mass="14640" checksum="ECF1478DB6BEF50C" modified="2019-02-13" version="1">MTDRAASNSDSPSMPGRLLYSGILAIMAIDGFRNNDKRVEVARESGVPTPEIMVPFVTGLLLVANLGILLWKYPRASAAAIVVFFLSTTPVIHDFWTMEGKERQANKINFQKNVALLGCALLLFNEAGTDTDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS47</accession>
    <name>A0A3N6LS47_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90064">
        <property type="protein sequence ID" value="RQG90064"/>
        <property type="gene ID" value="EA462_08675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="7"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="277" mass="31117" checksum="0C6DB3AD45B2C71D" modified="2019-02-13" version="1">MTPDIPPIGLGTDQNTALEDDFEVDFEACVETVTNAIEIGYRHIDTAQIYGTEPCVGAAIERSTVPRDDLFVATKVHYQRAEYEDALESVEQSLEDLGLEQIDLLYVHWPAGTYDPEGTLRAFNELHDRGVVANVGVSNFTPALLDEARDLLEPPIVAHQVELHPLLQQTELREYAERHDHRMVAYSPLIRGRVGDVPELASVAAKHDVSPAQVSLAWMAQKDVVPVPKASSETHRRENAEAIRLELDDEDIDTIDSIDQEQRIIDFEFAPWNDERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS64</accession>
    <name>A0A3N6LS64_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92713">
        <property type="protein sequence ID" value="RQG92713"/>
        <property type="gene ID" value="EA462_00310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="245" mass="25791" checksum="5C298D0B0337EBC3" modified="2019-02-13" version="1">MAADAPDTPDDSRTIQWRRDASTSRAVWLLWSLGVGTFFAAISIVVFWRLYDLAGQAGSGVQSIVVAFVVALFVTVLAVLLSNNAESQLERIARLLSITPPSGTALERATDAALGTIVMTLVIGSLMVAGRIVSQQGLLGDVGAGPFTGAAALLIPLALVAVALASFLRSAGALDLDDGALYLVDPDQKVDLSTIETVSRRRIADATVVTLGYAQPDGRYVPGPRRLVVPPDVAREIERAVDARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS90</accession>
    <name>A0A3N6LS90_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91387">
        <property type="protein sequence ID" value="RQG91387"/>
        <property type="gene ID" value="EA462_05285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="6847" checksum="F7019587F429E678" modified="2019-02-13" version="1">MVAGTERFDMSADGSLMADEDEEFIRRVLSIMAVWLIVTVIAGVALVLLRDPFAGLFAFAGAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS93</accession>
    <name>A0A3N6LS93_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_05340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91397">
        <property type="protein sequence ID" value="RQG91397"/>
        <property type="gene ID" value="EA462_05340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="16"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="259" mass="27352" checksum="42B1BCB1576C8A90" modified="2019-02-13" version="1">MGTQPHLLVEDGDLTDIALVPGDPGRVDRIASHCDESETVASNREYKVVNASYEGCELTICSTGIGCPSAAIALEELANVGVETVLRVGTTGALQSGIEIGDMIVATGAAKNEGTSKRYERAEYPAVPDYEVLSALVETANEREGNRTVRASNGEDAAGQVHVGPIASDDAYYAETEEYVADWEEAGLLSVEMEAAALFTLARRRGLRAGAICTVDGNLVDGTQKGTDTEDDELPEKAKNNVGRAIDIALEAATELSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSE0</accession>
    <name>A0A3N6LSE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92838">
        <property type="protein sequence ID" value="RQG92838"/>
        <property type="gene ID" value="EA462_01015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="157" mass="17659" checksum="95DD19FCBC8089C2" modified="2019-02-13" version="1">MPIPVDELTNDEPFPIKPDTNEYEALRFLVANQKYGFTPLEVADHTNISKSSASKTMARLFKKDLISRSSGVYYVEPDRADVLRQRLESLDAAVRLFDSTPDDDAYAKEGWEEELPSINPDDEPATAETRDSTTVDAEAERLIMDLEDNQGKTSDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSL6</accession>
    <name>A0A3N6LSL6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91507">
        <property type="protein sequence ID" value="RQG91507"/>
        <property type="gene ID" value="EA462_05975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="64"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="233" mass="24393" checksum="34466C2679CD1FEB" modified="2019-02-13" version="1">MNRDVGVTELIRTVLPEWAGPIFEITALLGDELVVVGVLGILVVVDVYRSADSGSDHLLSRETATLVAIVLGGLALTLVLKTTIDSPRPPASLQAVPREGTGFPSGHTMAATVLWVSLAYWSDRFSARGRLLIASIVIAVVGFSRLALGVHYLVDVVASVGFGVGYLLLAAKATGLEPMRAFATAGVLGVMALLVTAGSADGWLAFVGCIGGAGGWWLVNRPAVQRMWIATTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSR3</accession>
    <name>A0A3N6LSR3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="2 9">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cas4</name>
        <name evidence="11" type="ORF">EA462_02005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="2 9"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93008">
        <property type="protein sequence ID" value="RQG93008"/>
        <property type="gene ID" value="EA462_02005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="10">
        <location>
            <begin position="16"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG93008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="205" mass="23670" checksum="9B44974B0DEC0312" modified="2019-02-13" version="1">MKSPPTVGQRDKVVHVSALNEYVYCPRRFYYQRYHDEIGTPYELVDGRSKHQNQSNRGGWITERYFRADELKLHGKIDLIESEGGVFTPVERKRSESGQYYPSDEVQLTGYCMLLEAALNEPVNVGYIYLYSTDERHAVRITDRHRRTVREIITRIEEMSVGSIPPLTDNPEKCEACSAREYCMPAETARLEPEKAAGTGWEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSZ0</accession>
    <name>A0A3N6LSZ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93103">
        <property type="protein sequence ID" value="RQG93103"/>
        <property type="gene ID" value="EA462_02550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="174" mass="18634" checksum="28B77C0921899A7F" modified="2019-02-13" version="1">MSTDSTGEYDGPVTEEITVTVNGRAVTATVEPRLKLSDFLRDVCGLHGVRVGCEHGVCGACTVQQDDRTVKSCLSYAVQADGAAIETVEGLDDDGSLHPIQEAFHETHALQCGFCTSGFVMATKELLEENPDPTREEIQTGLAGNICRCTGYQNIYDAVERAGEKLTAETGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUK0</accession>
    <name>A0A3N6LUK0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91234">
        <property type="protein sequence ID" value="RQG91234"/>
        <property type="gene ID" value="EA462_04385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="279" mass="31568" checksum="4476D497EF8E8298" modified="2019-02-13" version="1">MYGVVTRNAEEVRWPEFDRGCYEVKDVTGRSAEPIEDGVNMVSCFGDNAAADADPSLVPVDDLGRPATRDRTYFDWDYICPSRRDYRTGLLEVVDDCVEANEDVRLDDVGFPRSEYCRCGVCERAFDESDFEDRLEWRARVITGFVAEAASRIPGRVYLTLYPDPYPGHLYERSGLDLAALEEYVDEFVVPLYDTAYETTYWLETIAKGFESALETPFSIELYAVNVDIDNLIHALDVANEYGNDVFFGYDATNAKAAIRRMRADDREGVTHGEPGSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVH7</accession>
    <name>A0A3N6LVH7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91704">
        <property type="protein sequence ID" value="RQG91704"/>
        <property type="gene ID" value="EA462_04840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="207" mass="23131" checksum="D9B722338C20DC9E" modified="2019-02-13" version="1">MDEACRNCPDLCETRTRVVHGYGDVGADFLFVGERPTPEADETGVPLVGTLETTDDERAESTADGLRRILERLALCDATSPSERPKLENVYLTNLTRCRDPDRAPTDEEVDSCEPYLNAEIRMINPEVIVPVGDRALREIATEYTTTAADDLAFPDAHATTIRGRGFALVPMVDPRAQTDDQTQDWLEHFAALMASDYRQTKGRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVI0</accession>
    <name>A0A3N6LVI0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PhzF family phenazine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92737">
        <property type="protein sequence ID" value="RQG92737"/>
        <property type="gene ID" value="EA462_00450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="299" mass="31782" checksum="C57BA65754F4E979" modified="2019-02-13" version="1">MDTIRVRQVDAFTDEPCTGNPAGVVPDADDLSRGQMQAIANEMALSETAFLRDSAEADRRVRYFTPAQEVDLCGHATIASFTHLREEGLDPGTSTLETNVGVLEIDVGADGTVWMTQEAPTVREVDVGYARTAEALGVDRAALEGASDDIPLAVASTGLPFLIVPITYLSDLGNAAPDMDAIEALTDSIEATGVYLFTFDALEAESTLHGRMFAPGAGVPEDPVTGTASGAVGAYLDHFGAFDDDLPDELRLEQGHYVDRPGSVRVRVDRDVRVGGRGVTVLDGSLVVPEDDEDDILEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVR3</accession>
    <name>A0A3N6LVR3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92857">
        <property type="protein sequence ID" value="RQG92857"/>
        <property type="gene ID" value="EA462_01130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="92" mass="10152" checksum="38955FAD9D12CB61" modified="2019-02-13" version="1">MSPTVDDLRNEIREALGRYERIESTAFTKEALGALCDAVGYDIETNPFPPKSEMRAGVLRTIGALEDVDPTQADRPFRKAELEAIAAALEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LW35</accession>
    <name>A0A3N6LW35_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphate ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="8">3.6.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstB</name>
        <name evidence="8" type="ORF">EA462_02100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.27" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93027">
        <property type="protein sequence ID" value="RQG93027"/>
        <property type="gene ID" value="EA462_02100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="31"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="278" mass="30618" checksum="F510ABA87DD950E7" modified="2019-02-13" version="1">MATQDNERALITTEVQTESTDRSDRPDETVLEARTLDVYYGEDQALTDVSIEIPEHKVTAIIGPSGCGKSTFLRSINRMNDQIDACRVDGELSFHGKNVYDDDVDPVALRRKIGQVFQKPNPFPKSIYDNVAYGLRVQGELDEGGMDDAVEEALRGAALWDEVEGKLDSSGLDLSGGQQQRLCIARAIATDPEVILMDEPTSALDPVAASKIEDLIDELVEEYTVVIVTHNMQQAARISDRTAVFLTGGSLVEEDDTATIFEDPRDDRVEDYITGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LW85</accession>
    <name>A0A3N6LW85_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4868 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93087">
        <property type="protein sequence ID" value="RQG93087"/>
        <property type="gene ID" value="EA462_02460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032359">
        <property type="entry name" value="DUF4868"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16162">
        <property type="entry name" value="DUF4868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="322" mass="37374" checksum="498A1F894401AFDD" modified="2019-02-13" version="1">MTTQNDAADTLKNAREFVQGNTSTDYLLVHKRETGPEIQTLEFRKTVQNELEKLFADVLTSYIDKVRDGSVGIRNLSAINTVTDESLIQHATIDELPDTELFRSLTSDSTYPTTKYDKNDPPDFQLIKVSDGKKHLIGIQNHRSLKTYDASKSGIPLLYRDAVYSKFESDLLIVPEALNAIYFEDQLFVMTPKSFEKMFEMRDEYEQKAETVISNFEDSGIRFSKSKITDDWMINGDIRVLRKLYTVHENEIPTYATPDRIKMVIDKYDIEVQYRKKNGFIELDIEEYTDIWKLLRLLNSDYAEAELIPDARLEIESKRIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYB3</accession>
    <name>A0A3N6LYB3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86702">
        <property type="protein sequence ID" value="RQG86702"/>
        <property type="gene ID" value="EA462_16310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="155" mass="17269" checksum="DF950C24F80BE0D2" modified="2019-02-13" version="1">MTNQYYPTTDVDRIVVETGDTRVDVTKVRTPTGERIQIEHDDLGQIRLDAVELEALTWQDEAFFADLVDGEYDYRNVDPRPKSAADLQVSNEYALARLRGSDDGAGVSLTAPKMGYGIGIDARVLAAVVTRPKTFFSELLRTPYGPDDDDDVHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYN1</accession>
    <name>A0A3N6LYN1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HlyC/CorC family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_12930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87773">
        <property type="protein sequence ID" value="RQG87773"/>
        <property type="gene ID" value="EA462_12930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="8">
        <location>
            <begin position="25"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="233"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG87773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="293" mass="32174" checksum="BFFC460537229EB5" modified="2019-02-13" version="1" fragment="single">MTRSLPLEMMVAAYDVPVVGFEIAESTVTLLGGFAVVVLIALSGFFSSSEIAMFNLPKHRLEGMVEDGTEGAALVKRLKDDPHRLLVTILVGNNIVNIAMSSIATAVLSIHFGGLLGVILATFGITAIVLLFGESVPKSYAVENTESWAIRISKPLKATEYFLFPLIVLFDYLTRQVNRLTGSTGAIESPYVTRDEIQEMIESGEREGVLEEEEHEMLTRIFRFNNTIVKEVMTPRLDMTAVPKDAAIDEAISICIQSGHARIPVYEGSLDNVQGVVHIRDLVRDLNYGETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYY5</accession>
    <name>A0A3N6LYY5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93094">
        <property type="protein sequence ID" value="RQG93094"/>
        <property type="gene ID" value="EA462_02505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="122" mass="14092" checksum="A11C5A30E2639A96" modified="2019-02-13" version="1">MSDDTRRSTQSSEEMFESIENISPDTVFDLLSHRHRRIVIELLVASDGVLTIRDLRNEIIEKEQGVEITEGDKEQIEQVFISLYHIHIPKLAEEGIVNYDQERTVVEPTEKLSNLVPFLSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ26</accession>
    <name>A0A3N6LZ26_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87973">
        <property type="protein sequence ID" value="RQG87973"/>
        <property type="gene ID" value="EA462_14035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="135" mass="15680" checksum="5B2F56626AD0C8DC" modified="2019-02-13" version="1">MADSMAEQLQQDMQCEGLLECIHGLKQLDKDCYRAMVESDGPLTIDEVAERVDRERSTAYRAIQRLLQSGFIQKEQINYDQGGYYHVYYPTDPSQIANDMQRMLNDWYAKMGQLIHEFEDKYQQVDDGTVAVDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ35</accession>
    <name>A0A3N6LZ35_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87022">
        <property type="protein sequence ID" value="RQG87022"/>
        <property type="gene ID" value="EA462_15380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="173" mass="18900" checksum="51B74BAB2D13AD75" modified="2019-02-13" version="1">MSSRTSELESPKASGDALEAELVQTIDALEYVGDRTATWHDARTTTLLEPELSLLFYGIVVVEADVPVEIKGCQIETSNGARSTRGRFYVKRNAHQQLLEAAGMYLFVVYVPRPGLPQVARAVVPATIVDELLSDRWYDVGGSRSENEVAKLAWSHVIDPTNVDPSTATGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0U5</accession>
    <name>A0A3N6M0U5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89280">
        <property type="protein sequence ID" value="RQG89280"/>
        <property type="gene ID" value="EA462_11640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="655" mass="71268" checksum="016FC10DB1479244" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M299</accession>
    <name>A0A3N6M299_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89241">
        <property type="protein sequence ID" value="RQG89241"/>
        <property type="gene ID" value="EA462_12820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="411" mass="43679" checksum="93B1CCEE597751D8" modified="2019-02-13" version="1">MESLSAVVLAAGEGRRLRPLTRSRPKPMLPAATTPVLERVLDELIDAGVTDITVVVGYQRERVQSHFGPTYRNVPLTYVHQRSQLGTGDALLSIRGVVDGSMLVINGDQIVDRRIIADVVSAHERSDSVATLGLLQRSEVSTYGGVLVDRATDEETPTAPVVELVERPRDDREYRLNAGVYGLEPEIFEAISETTPRTGEHSLIDAISYLLETGSDGVPPVRGIESGGLWVDATYPWDVLEVAIELLDRGRGDRTTNGRERRTISPSSSIHGTAIVRGPVVVDDNCEIGPGAIVGPYACLGENVTVESGAVVERSVLDTDTRVRTNATVLECVTGQAVEIGAGTTIPGGPGDVRVGDRIFEEAALGALLADRVRDDGGVTYTPGSIVGPNATVRAGTTVRGSVAEGTEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2D6</accession>
    <name>A0A3N6M2D6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps19e</name>
        <name evidence="6" type="ORF">EA462_12235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in maturation of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89291">
        <property type="protein sequence ID" value="RQG89291"/>
        <property type="gene ID" value="EA462_12235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01474">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_S19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027548">
        <property type="entry name" value="Ribosomal_S19e_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_S19e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="PTHR11710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="151" mass="16845" checksum="1247150EC55057A0" modified="2019-02-13" version="1">MATMYDVPADDLIEALAEDLGDRLDEPDWAQFAKTGVGRELPPQQEDFWATRAASLLRKIADRGPVGVERLATEYGNAKSGSNRYRVAPDRRTDGSRNVIRTILQQLEDEDLVETAEGEGRRITPNGRSLLDDTAGTVLEDLDRPELERYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M382</accession>
    <name>A0A3N6M382_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_10115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90320">
        <property type="protein sequence ID" value="RQG90320"/>
        <property type="gene ID" value="EA462_10115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044065">
        <property type="entry name" value="ACP_MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51901">
        <property type="entry name" value="ACP_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="ACP-type MB" evidence="5">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="206" mass="21652" checksum="CB0DDBAD1DBD79DB" modified="2019-02-13" version="1">MESELSVRDVLTTEYVGVSESDTVLAAVQLMREERASCVLVVRGSEPVGIMTEWDVLGIMADEDDPTETTVGDAMTAPVISLGPDRSLADAATMMGRENIRNVVVEAGDEVFGLVTQRDVITAAGSFQATMTPTRSSASTGSVSTANEVDTEESVTRSVSEAADERALPNGGDEFSTQGVCEACGSLSDALWDANGRLVCSDCRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3B4</accession>
    <name>A0A3N6M3B4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_17080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86183">
        <property type="protein sequence ID" value="RQG86183"/>
        <property type="gene ID" value="EA462_17080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="81" mass="8909" checksum="E06982061E8A4E54" modified="2019-02-13" version="1">MNIEHFAHETGQAVRRYEYDDHSMLAVDFGPRSEATVDLVGGTVIVVDGGDQYELELPDDAGDAHTFMKNGVLTIELEADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M508</accession>
    <name>A0A3N6M508_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Methenyltetrahydromethanopterin cyclohydrolase</fullName>
            <ecNumber evidence="4 10">3.5.4.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Methenyl-H4MPT cyclohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mch</name>
        <name evidence="11" type="ORF">EA462_03570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin</text>
            <dbReference type="Rhea" id="RHEA:19053"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58018"/>
            <dbReference type="ChEBI" id="CHEBI:58337"/>
            <dbReference type="EC" id="3.5.4.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the MCH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.27" evidence="4 10"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91090">
        <property type="protein sequence ID" value="RQG91090"/>
        <property type="gene ID" value="EA462_03570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018759">
        <property type="term" value="F:methenyltetrahydromethanopterin cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00486">
        <property type="entry name" value="McH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003209">
        <property type="entry name" value="METHMP_CycHdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02289">
        <property type="entry name" value="MCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03120">
        <property type="entry name" value="one_C_mch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG91090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="310" mass="33014" checksum="9A308A6072AAEC4A" modified="2019-02-13" version="1">MESLNRMAIELVDEALEYAEELNVGGYDLDNEATVLDFGLDFDGGIEAGLLLTEIQTAGMATLNYDLGEIGDASVPFVQLSSDQPALSLLCSQKAGWELTTEDFEGLGSGPARALVAREEEFRRIGYTDAFDLTALALEADSHPTEAAAEQVAELAEVETGSVFLLAYPTASLVGSISNAARVAELATFRLVELGYDPLDIVSATGRGPVAPVPGDERTAIARTTDAIAYGGTAHLSVREDADVFDAVPSTAGDDHGRPFADVFDDLEWEFEEVPSDLFAPARVTVDVVGGPTYVHGETDEELLLESFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5K4</accession>
    <name>A0A3N6M5K4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88019">
        <property type="protein sequence ID" value="RQG88019"/>
        <property type="gene ID" value="EA462_14280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="74"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="259" mass="29204" checksum="A3B16C96AB05BCC2" modified="2019-02-13" version="1">MDADPEDDLTRVADAFGTALREYYDGDGPGVYTTVRDDGKRTKADLSHYFDSHDEWESPTKQALTYIRPGDRVLDVGCGSGRHALWLQEQGYDVVAIDQSQQAIDICEDRGIDSCSVMDMTDLQFEDDAFDTILVVGNIIGLGGSLTDISGYFDEFDRITTDRGRVITDSQNPFPDGIEDSAYFRDNQIDDRDASTVRFRVQYRDLVEDWLEIAMLGEDELTTLLEDTSWSVTETIETAPGDGWYSVAMQWYFAVIDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M635</accession>
    <name>A0A3N6M635_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="5">SDH</shortName>
            <ecNumber evidence="2 5">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">aroE</name>
        <name evidence="9" type="ORF">EA462_05880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="2 5"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91490">
        <property type="protein sequence ID" value="RQG91490"/>
        <property type="gene ID" value="EA462_05880"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="6">
        <location>
            <begin position="121"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="8">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="130"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="274" mass="28319" checksum="FF6CA84C8978F114" modified="2019-02-13" version="1">MDVFGLLGNPVGHSLSPPMHETAYDELGLDARYVTFEPETDELEAATTGADALGIAGLNVTIPFKQDVLEIVEPDDLAARIGAVNTIDFSRSSGSKTEPPTGHNTDAAGAMRALCDHDVTVDGARAVVVGAGGAGRAIAFGLADAGATVDIANRTESTAHDLAADVPGATGHGLETDALETLVGDADVLVNATSVGMEEDATPVQADVLHGDLVVMDAVYRPLETRLLSEAAAVGATTVDGAWMLLYQGVEAFELWTDERAPVGAMNEALRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6F3</accession>
    <name>A0A3N6M6F3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acVLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91650">
        <property type="protein sequence ID" value="RQG91650"/>
        <property type="gene ID" value="EA462_06795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040783">
        <property type="entry name" value="VLRF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18859">
        <property type="entry name" value="acVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acVLRF1" evidence="2">
        <location>
            <begin position="184"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="312" mass="34707" checksum="7A383C92FA1D09D6" modified="2019-02-13" version="1">MFDVDRLLGRASLKERIDELEDETERLRSRYEAESERRATAATARQEAEETINRLEDRIAQLEGELERVDGVDSGLEFRSRERMRGTELADVLDRLASIRTAPEGALTAVVSDGETGVGHRGVDLDDVLGERAALLDDASPCVCYVDDAGLVSVALRPPILPAIEPTWDDRFAVDREWFLGTDRYVLALVRADLFALGVYDGDERTAYRGFESDVKGAHSKGGFSQARFERIRDDQIDDHLERCRATLSEYRSDRPGDEPLYLTGQRGVIDTLVDDGTLEPDATTAVDATGDPKSALDDAHRSFWTTDVLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6I5</accession>
    <name>A0A3N6M6I5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91690">
        <property type="protein sequence ID" value="RQG91690"/>
        <property type="gene ID" value="EA462_04010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043811">
        <property type="entry name" value="DUF5793"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19106">
        <property type="entry name" value="DUF5793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="156" mass="17312" checksum="5EF9F971759F254E" modified="2019-02-13" version="1">MRREHFTLDVSNVDWVETDAEPSKPSVSIDFTGPSTMLRERLTGLDGDILDASETDVALRLQEPFGTDAPGVVSVTNRVTGEFILELNEDAEDVLLFIRAARGYGEATDEDGGRYEVTISLEGDHFVTYDKRTFLVYDDEGSLLRQHSLIPSGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6Z6</accession>
    <name>A0A3N6M6Z6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF364 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91101">
        <property type="protein sequence ID" value="RQG91101"/>
        <property type="gene ID" value="EA462_03635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007161">
        <property type="entry name" value="DUF364"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04016">
        <property type="entry name" value="DUF364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF364" evidence="2">
        <location>
            <begin position="129"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="287" mass="30550" checksum="CEEBBBB8444020CD" modified="2019-02-13" version="1">MTDSILETVSDRLRARDALRSVRCNRVTVGDSVVLVELSDSSESDDHPLAGLAHRPRNTELDLDGTESSRSNRTVDELLEPIEADDRDCDENVGSLERAVAVATVNALSVPFLEWRAGDPMALLDPSVETITTVGLFRPAFRKFEDVDVRVIERTSVDDDLSTPDGVRVSAFEPADAPRAMAGSEVVFVTGSVFVYDGITNYLETAPDAATVVVVGATASFLPGPLFASGVDVVAGATIDEPGRVREAISDGSCGTGLHDAGVRKVYTATDRPSGIQLESVSTKDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8I5</accession>
    <name>A0A3N6M8I5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89776">
        <property type="protein sequence ID" value="RQG89776"/>
        <property type="gene ID" value="EA462_07085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="256"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="588" mass="65884" checksum="DD395D5ACF770D9D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8K0</accession>
    <name>A0A3N6M8K0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91701">
        <property type="protein sequence ID" value="RQG91701"/>
        <property type="gene ID" value="EA462_04775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MFS" evidence="1">
        <location>
            <begin position="11"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="423" mass="43574" checksum="B16A4D68132F604E" modified="2019-02-13" version="1">MSGAFRGRSLVIGAVIVSTFFVGFGGGVIFPILPNLGELLGISPFLVGVILSANRFSRLVSNAPAGILVDRVGTRTPFVVGMVIQGVATFGYVVAVLAPVPEAWFLGSRLIWGVGSALVFATAYTIAADVSDGGSRGTSMGLIRGGVLFGFPCGVVLGGIISEFWGTVVAFVVATAFAAVASAIAYATVPETHVEGDEHRAIKPWEIDMSVPALTVGFVNFAVLFAYIGALFATLVLFLDRNELGVFGFDAQASSGIFMALTVIAAGAFMFLGGYVSDRRESRVPTLVVFLGTTFVGFVLLAFAGSVWTLAIACLFIGAGQGGTSGPLMALLADLTPEERMGRAVGTNNVLGDVGGGLGPIVSLPLIGIVGFQPIYVACAVLPIVAGVILVAGVHRETGQFLPAVSLTDDSSRDTESTPDHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8W1</accession>
    <name>A0A3N6M8W1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">gcvH</name>
        <name evidence="6" type="ORF">EA462_07855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89916">
        <property type="protein sequence ID" value="RQG89916"/>
        <property type="gene ID" value="EA462_07855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="127" mass="13902" checksum="BC9EC25C7E452C43" modified="2019-02-13" version="1">MSFDVPEDRRYLGSHEWAHETGDVVRIGITDFAQDELGDVVFVELPDDGDALTQGDEFGIVESIKAVSDLYAPISGDVVAVNDALFDTPELVNEDPLGDGWMIEIEPNDDAELEGLLSAEEYDDQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9S9</accession>
    <name>A0A3N6M9S9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">hflX</name>
        <name evidence="10" type="ORF">EA462_10035</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90306">
        <property type="protein sequence ID" value="RQG90306"/>
        <property type="gene ID" value="EA462_10035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045498">
        <property type="entry name" value="HflX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19275">
        <property type="entry name" value="HflX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="186"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="253"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="319"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="347"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG90306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="433" mass="48437" checksum="A89797E57FC675B0" modified="2019-02-13" version="1">MSAIVAKRVDSGTADTTEIRDLAAAAGYTISGEVTQSRRADPALQFGEGKAEELAARVDETDAKTVVFDNRLGPYQMYNLGQLLPDGTEVIDRFTLILEIFGQRAQTRKAQLQVELAELRYELPRAEAKSSLAKRDEHPGFMGLGEYDESRERDIKAQISRITDELEQIERTEEHRRERRRDSGFDLVALAGYTNAGKSTLLRQLAADLEIDENEDLHPDLESTAESQDRLFTTLGTTTRRAAIQPRDVLVTDTVGFISDLPHWLVESFKSTLDSVYRADLVLLVVDVSEPVDEIHEKVVTCHDTLYERNEAPIVTVLNKIDRVDDEELTEKREALSGLAPGPVSVSARTGTNVEELLERIDDELPDWLEERLVLPMTDDTMSLVSWIHDNANVNDVTYGDEDVHVSFEARPAVVSRARSRAGELERTSVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9U5</accession>
    <name>A0A3N6M9U5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amphi-Trp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90336">
        <property type="protein sequence ID" value="RQG90336"/>
        <property type="gene ID" value="EA462_10200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027598">
        <property type="entry name" value="Amphi-Trp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20068">
        <property type="entry name" value="Amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04354">
        <property type="entry name" value="amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amphi-Trp" evidence="1">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="84" mass="9426" checksum="2D5FAB3DA3BE39F2" modified="2019-02-13" version="1">MSETTSHDEDVSREEAADLLQELALELRDGGPAEVRVGNKMLTLTPDSVIEYGIDVEERSPMLGGDREQITVSLEWDVNHEEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MA13</accession>
    <name>A0A3N6MA13_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93160">
        <property type="protein sequence ID" value="RQG93160"/>
        <property type="gene ID" value="EA462_02860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="302" mass="32497" checksum="33A6861293615571" modified="2019-02-13" version="1">MSREQRSVLDRVRQPEYTGANRCVPCTAVNLGIAVVLAGGIAIVAPLAATLVLVSSVAVIYVRGYLVPGTPTLTERYVPDRLLAAFDKHPEPRSGTLETNGDGLETEAGGSVDEMSPDPSDGGASAAIDPESTFLAHDVLIPCSDLADSDGAHPDDDLCLTEDVERAWRREIDAHRGGDREDQVAAFLETDPERVRIVQPRDSGVRALVDDRSVARWESDAALLADLAGATVLATRVADWERLSVENRSRLANGLRTFVGQCSACDGEVSLDEETVESCCRSHQVYAITCEDCNVRILEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MA74</accession>
    <name>A0A3N6MA74_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93220">
        <property type="protein sequence ID" value="RQG93220"/>
        <property type="gene ID" value="EA462_03230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="153" mass="17107" checksum="FD7BD9CDF6802482" modified="2019-02-13" version="1">MRRRTVVVGTAAVVALSGCLFDDRDDSAEPPELHGFGTIEIVVDDSAIDLSEDRFQAEHADDYSMDFHLHEDTDFWYMEGDEPVTFAAGIDVLPHFAYRRDGDVHVVSYEETTYRGDESGTELTFAVDDTDVEPTDYVLEDGDDLSLEITTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MB60</accession>
    <name>A0A3N6MB60_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92691">
        <property type="protein sequence ID" value="RQG92691"/>
        <property type="gene ID" value="EA462_00195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="280" mass="30048" checksum="7F19E9C509C25FA7" modified="2019-02-13" version="1">MDTPAVIAHRGYAGVAPENTIGAAVRAAERSETSMIEIDVQPAECGTPVVIHDERLEGARDGRPLTDATGLVRDASRSKLAETRVLGTRESVPTLASLLEAVPATVGLNVELKNPGTASLRFSESLPQDERDGRRECWRPFVERVVSDCHGFGGEVLFSSFCEGAIAAVRDVDPKYAVAPLIWDDLEAGLEIARRYDCEAIHPPRNAITGSALATTKYAGFPPDEPAIDVLEIAHDEGRAVNVWTIETWHGFADLAAAGVDGIIADYPGLGTFSRDDRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFN2</accession>
    <name>A0A3N6MFN2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92716">
        <property type="protein sequence ID" value="RQG92716"/>
        <property type="gene ID" value="EA462_00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="137" mass="15176" checksum="213153FB6A938534" modified="2019-02-13" version="1">MTRHDVLLKVSALFGFAFGLGLGVYQTFTLDPMISTMHDGVPYWMRVTHIHILGLSLVTFVLSFVIDDAFESHRGKVAWLTVLGQWGTPLTLYPVVALGIVVFGPIHNLVSLLTFVVVLAFAVAYARSWSQVSEPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MQT0</accession>
    <name>A0A3N6MQT0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86179">
        <property type="protein sequence ID" value="RQG86179"/>
        <property type="gene ID" value="EA462_17060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005948">
        <property type="entry name" value="ThiB-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01254">
        <property type="entry name" value="sfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="390" mass="42793" checksum="0A2069BF9305EB5F" modified="2019-02-13" version="1">MRRRTFVGAIGGGATLGFAGCVTRDDENGGNGGNGSDDGSGSDDPADGTDDSSTDSGEDELSGTLEVVTYESMIDGENPAGPWLKDAFEDEYPDVELEWTLLPDGGINHYIQRADQGADIDPDVYLGLNIDDLVTVDDNLADGGLFQELDTGAIEHADRIRDGLDMGDPHGRALAYDTGYISLVYDESEVDAPETFDDLTEPEYEDALLAQNAQTSDPGQAFLLWTIDAFGEDGYLDYWGDLEENGVRVLEDWTESYYGAYMEEERPMVVSYSTDQVFAVAEGNDMTRHQIAFPNDQGYANPEGMAIFDDSESADLAAAFFDFVLSNEPQAEIAQRNVQFPAVDEEYVDLDEEFDEYAHVPLEAVTVGYDQLRGNLDGWVDDWAREFASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTE7</accession>
    <name>A0A3N6MTE7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-nitrogen hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88075">
        <property type="protein sequence ID" value="RQG88075"/>
        <property type="gene ID" value="EA462_14600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="30032" checksum="F4ECC7A84DC1E80C" modified="2019-02-13" version="1">MRLTVCELPDNRSRFIDSWRGLCDHVETERSELVLLPEMPFSRWLPMKQGGSEEKWGDAVEAHDDWMDRMNELAPATVLGSRPTHSEGRRLNEGFVWTESSGSRLVHQKTFLPDDGPWFWEGSWYERGEDDFSLVECASAKCGFLICTEIWGAEQARKYGHDGAHLIVNPRVTEPQRREQWRAGTQAISTISGSFVASSNRVTIPTESVEEIPFGGNGWIVDPDGTVLAETSRNQPFVTVEIDISVAEKAKKTYPRPAFEGMERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTV4</accession>
    <name>A0A3N6MTV4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88812">
        <property type="protein sequence ID" value="RQG88812"/>
        <property type="gene ID" value="EA462_10430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="135" mass="14715" checksum="4D479113794343C3" modified="2019-02-13" version="1">MEDIFVARVMSSSLKTVRPDTLVEDAGQLILDNDISSVIVVDDEGHLEGILTTTDFVDIVARSHPKAETTVSRYMSTDVVTASAQDSIRDVADLMVEHGFKHVPVVDDEEGAIGIVTTTDLASYLSRLQRPSPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUY1</accession>
    <name>A0A3N6MUY1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89212">
        <property type="protein sequence ID" value="RQG89212"/>
        <property type="gene ID" value="EA462_12665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043833">
        <property type="entry name" value="DUF5810"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19126">
        <property type="entry name" value="DUF5810"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="153" mass="16072" checksum="E497AC39C2CC2B41" modified="2019-02-13" version="1">MGYACPVCDAEQADAVHLANHLAVTASVGREDHLEWLDDHAPDWADRSPAELGAIVSAEAPEIETPSFDDSGHAHGATHEPGRPSGFEDGLAGQRRATERGDLTTEAAGVLEEARRLTRRMAASSGSDDGDHGESETGRSTDEPSEGDGNENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWC7</accession>
    <name>A0A3N6MWC7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89782">
        <property type="protein sequence ID" value="RQG89782"/>
        <property type="gene ID" value="EA462_07115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00050">
        <property type="entry name" value="rRNA_methyl_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="28389" checksum="3215400CF0522E52" modified="2019-02-13" version="1">MSDQSSRSDSTTRSSKPAVAVVDAQSPGNVGTIARAMKNFGFEELLLVDPPELDPDGDAYGFAGHAREDVLPNATEVTFDEIVENYHTVGCTAVTNEDDRSHVRFPFSTPADLSDRLSTVDGRTALVFGRERVGLTNEELARIDEICSIPANADYPVLNLGQAATIVLYEIRPLTLSDEDIQLPDVERVRASEPTLDRLYGQWESLLAEINHPEEKREKTMRMLRRVHGRADLTEREVNTLLGLVRRATERPDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWL9</accession>
    <name>A0A3N6MWL9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89882">
        <property type="protein sequence ID" value="RQG89882"/>
        <property type="gene ID" value="EA462_07670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038482">
        <property type="entry name" value="Tp34-type_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="448" mass="48924" checksum="3C51526D392BF7A1" modified="2019-02-13" version="1">MQEHDTIDRRTVIRLGAATGLLAAAGCLELGGNGEDPDEDTGESTEDDDVTVAPELVEVDDPPAAVYLPTHREAMRMLEPIEAGEFVLAPMLSYPHPFWVIAGGGTDDEVERVDPDDGRGVHMMFTLWDAETGIVLPADEGAQIRVFRDGESVGSPRSPWAMISQGMGFHFGDNVPLPEDGTYTVEVTIPSISTTRTGALEGRLTESRTATFEFVYDDEFRHEVVDGVEYFDEEYWGRPGAIGPMDHGEHGDGHGEHGDDGHGEHGDDGHDEHGDDDHDEHGDDGHDEHGDDDHDHHVPYSALPRVEEYPGTLLVGPTSDSVPEETEDLPRSGDAAMLATVFESGFRLADGDERYLLVSPRTPYNRVPLADMSLSVTVERDGEVVGESTLEQTLDGEYDLHYGASIADIEPGDSVTITIESPPQVARHQGYETAFLEMPPVEFVLEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3L3</accession>
    <name>A0A3N6N3L3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_00305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92712">
        <property type="protein sequence ID" value="RQG92712"/>
        <property type="gene ID" value="EA462_00305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="396" mass="39214" checksum="94E4E890DF83504B" modified="2019-02-13" version="1">MVEIVTIATFLVAAVASLFMAWAIGAGSSGSTPFAPAVGANAISVMRAGFLVGILGFAGAVLQGANVSEAVGTELIGGVTLSPLAATIALVIAAGLVAIGVFAGYPIATAFTVTGAVIGVGLAMGGDPAWPKYAEIATLWILTPFVGGGLAYGIARTLRAEALSETTLIVALAALVGVIVANIEFAVLDSADGGASIAQASSRILPVSELVGVAIVTLLVAGAWAAVIAFDLAGGVERGERHFLLILGGLVAFSAGGSQVGLAIGPLIPLSGDLELPLIALLVGGGFGLLLGSWTGAPRMIKAISQDYSSLGPRRSIAALIPSFLIAQIAVLYGIPVSFNEIIVSSIIGSGYAASGAGGGVSGRKMAYTVLAWLLSLAGSIAISYVGYAVLAAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4R5</accession>
    <name>A0A3N6N4R5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ORF">EA462_02990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93182">
        <property type="protein sequence ID" value="RQG93182"/>
        <property type="gene ID" value="EA462_02990"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG93182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="395" mass="43568" checksum="8FC124ECD46D485E" modified="2019-02-13" version="1">MTRVALAFSGGLDTTVCVPLLEEEYGYDEVIGVTVDVGQPAEEFDEAEETAEALDLEHHIVDATDEFADLCFEGVRANATYQGYPLGTALARPVIAAAILEVANEQDCTGIAHGCTGKGNDQLRFEAVWRDSDLEVIAPVRELGLTREWEQEYADEKNLPVEGGSGGDWSIDTNLWSRSVEGDKLEDPNYVPPTEIYNWTDEPSGETEEIEIRFENGYPVAIDGEEYDPVALIEYLNELAGSYGVGRTDSMEDRMLGLKVRENYEHPAATTLLNAHEALEGLVLTQEEREFKQLIDQRWSKKGYEGLVDAPLVSALEGFIDETQTRVTGTVTIRFEGGQARAVARDSEYAAYSAEHASFDTESVGKISQEDATGVAKYHGFQRRLANSVIDAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUB7</accession>
    <name>A0A3N6NUB7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagella protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86750">
        <property type="protein sequence ID" value="RQG86750"/>
        <property type="gene ID" value="EA462_16580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006752">
        <property type="entry name" value="Arch_fla_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009205">
        <property type="entry name" value="FlaC_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04659">
        <property type="entry name" value="Arch_fla_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05377">
        <property type="entry name" value="FlaC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arch_fla_DE" evidence="2">
        <location>
            <begin position="267"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="424" mass="45232" checksum="40A97F7EE52D8F9D" modified="2019-02-13" version="1">MTFLLFSGLGADDEDDADDGGDDLLGGGDDGLLGDDLGFGDDDGGSDDDELNYRLDEVEKEIDSLGNKVETVRGENEKISDSISTVERNVDKLVDLYEIVTHGINPFVGDQEIGNAFETATEQGGFGASDDPADEIDPEIADAEATDFLADDIESDDDIDDLDEDPFSELDGEDELDSEPDDEAMDDKTAEDELDDFLAPDDDDPDDDDALEADDDPLGDDDDPLDPSTGIEDDDPLGDGADGLTTDETAAAVADDLEDAVNGEIGEPPYLVRHPAQNGAEITTLQWIEFLVESAGIDGASRTIAYYETVGWISPPVETYLQSLLNGFGDESVSPADDLDTHSPLGTNAHRRSLRYIAAIATPERNPDSLEDASNTEHEAEHTTGSVDDPSAEPDTESAGEPIADRDDRLAGGFEDGVDNGRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVL4</accession>
    <name>A0A3N6NVL4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87892">
        <property type="protein sequence ID" value="RQG87892"/>
        <property type="gene ID" value="EA462_13600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="5"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="322" mass="36512" checksum="D76AD1103C67B832" modified="2019-02-13" version="1">MVQRIDAFGHITPPEFYDEMSDVHSTPALHNLYFEPIWNVDRRLEDMDDHGIDKQVLTLANPPIWRGIDPDDALPLTRLANDLVREVADDHPDRFIPVATIPFATEEYVEEFERCLTDLDMHGVQIFSNVDGRPVDSPGHMALYETAANAGVPVWIHPQLHEWYDWLSEYEIHRTIGWPFDTTAAMARMVFGGAFEQNPDLDVIVHHLGGMVPFFIGRITTFFEARVNNPDMYPEFEAPDFSTTVREQFQNFYGDTVIGGEVPPFECGRSFFGDDGVVFATDYPFGPEGGRRFMKQAVDVVDSVEDDDAYEAISSGNVQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVP6</accession>
    <name>A0A3N6NVP6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87942">
        <property type="protein sequence ID" value="RQG87942"/>
        <property type="gene ID" value="EA462_13855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="93" mass="10391" checksum="CA5390D6F3AC0936" modified="2019-02-13" version="1">MTEHTIHFVNEDITFTMSEDSNDSILDAAEKHGLDLQYQCRMGHCGICTVRAEGEVEQGDAMMLTESEKEEGYILTCVATPLSDLEIYSDETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVT7</accession>
    <name>A0A3N6NVT7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Baseplate_J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88002">
        <property type="protein sequence ID" value="RQG88002"/>
        <property type="gene ID" value="EA462_14185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1253" mass="136204" checksum="73BF6EA23E1A949C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWB0</accession>
    <name>A0A3N6NWB0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_10415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88809">
        <property type="protein sequence ID" value="RQG88809"/>
        <property type="gene ID" value="EA462_10415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="20"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="487"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="956"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG88809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1258" mass="140367" checksum="0CA3CFB5512EBF89" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWM5</accession>
    <name>A0A3N6NWM5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88959">
        <property type="protein sequence ID" value="RQG88959"/>
        <property type="gene ID" value="EA462_11255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="161" mass="17532" checksum="618A3B7822B53214" modified="2019-02-13" version="1">MSEEIIKSESTTEHLHVLGATITITADSDDTDGEFSVKNMLAPPGFENGLHTHEPAEVFHVIDGEMLLYVDGETQYLKPGMTGYVSAGERHGMRVEGDEVLRVLIVMSPAGAEDFFRAVGEPAADRNLPEPREVTNADLEAIFATGEEHGFEFFGPLPADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYE3</accession>
    <name>A0A3N6NYE3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89839">
        <property type="protein sequence ID" value="RQG89839"/>
        <property type="gene ID" value="EA462_07420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="148" mass="15349" checksum="3A7A7F1F2E9B7CA2" modified="2019-02-13" version="1">MDDRALSTALSYALLLGVTVMLMGGLSVAAGGLLESQHERAVEAELDVIGERVTADLQTADRLTHTAGETESLAVRSSSPQLVSGGHYTIDVVNGGEETTLVVESADVDVTTETTVPTTTPVAETTVIGGELEITYDSESDELVIANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ30</accession>
    <name>A0A3N6NZ30_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86746">
        <property type="protein sequence ID" value="RQG86746"/>
        <property type="gene ID" value="EA462_16560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="252" mass="27793" checksum="4E7320DC86F6D377" modified="2019-02-13" version="1">MSQLNNIFSIGLDDRDRLNKELGGGIPTGSIVLMEGDYGAGKSAISQRFTYGLCETGKSVTFLSTELEVKGFVEQMDSLDYNVEEHLLFENLLFLHGDLDSGGVLSSSGEEDTRQDLLTDLMDEDTIWSADIIVIDTFDAILRNDPKFEALVRQNDERQAALEIISFLRNVISQGKVVVLTVDPSTVGEEAIGPFRSIADVFIELEMIEVGNDIRRQLFIKRFAGMGEQVGDRVGYSVRSGTGIVIENRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZW0</accession>
    <name>A0A3N6NZW0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_15160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87126">
        <property type="protein sequence ID" value="RQG87126"/>
        <property type="gene ID" value="EA462_15160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="155" mass="17027" checksum="EC8D39C1B3F84C1A" modified="2019-02-13" version="1">MTYENLDAKLVNALLGDGRASLRSLAEELDVSVTTVSNHLSDLEEEGVIEGYTPRIDYDAVGYDVTAVIQLQVEGNALPEITDTLRDHRQMISVYEVTGDYDVIAIGKFRDTDGMNDQIKALLTDPDIKASNTSVVLNAVSENEQFTLDVDVDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1L6</accession>
    <name>A0A3N6P1L6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rhomboid family intramembrane serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_11385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88985">
        <property type="protein sequence ID" value="RQG88985"/>
        <property type="gene ID" value="EA462_11385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="7">
        <location>
            <begin position="64"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG88985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="224" mass="23076" checksum="DC50C4A9C5C8C75A" modified="2019-02-13" version="1">MANRSRTQPTQSVGSEPRASGDSGSTGPIIELLVVFAVVFALQSITAVVGVMTGLFVLSPPLSDSPWTIVTSVYAHGSLWHLLSNSLALVVFGWPVARATTRLRFHTFFLMTGALAGVAQVGLTGFAATLSLVPATPTAGVLGASGAVFALLGYLVASNRLSDGLASFVDIPRWLTILVFAVLAGILTLATAAPGVALIAHFTGFLVGAVAGRARVLHVRSPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3J9</accession>
    <name>A0A3N6P3J9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine 2-epimerase (Non-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89875">
        <property type="protein sequence ID" value="RQG89875"/>
        <property type="gene ID" value="EA462_07625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="1">
        <location>
            <begin position="28"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="369" mass="41002" checksum="41807AB12455363D" modified="2019-02-13" version="1">MRVCSIVGARPQFVKAAVISRKLREVGEEVLVHTGQHYDEELSGVFFDELDIPEPEYNLGVQSDTHGRQTAAMIAALEPILEETEPDAILLYGDTNSTLAGAIVGSKRDLTVAHVEAGLRSDNWEMPEEVNRVLTDHASSLCFAPSRTAVTNLAEEGITDGVHWTGDVMYDAILDARERSRRRSTILEELDVAEESFVLATVHRASNTDDPENLAAIIDGLSDASLPVVFPAHPRTASRLREFDLWDRATRDLRVIDPQGYLDFVRLLDATERVATDSGGVQKEAFFLSTRCLTLREETEWTETVDCGWNRLVGPNARSIHESLHEDWEPESSPHPYGDGAAGRRIVRLLQERLAVADPERRVEAPALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4E4</accession>
    <name>A0A3N6P4E4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_09755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90255">
        <property type="protein sequence ID" value="RQG90255"/>
        <property type="gene ID" value="EA462_09755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041346">
        <property type="entry name" value="DR2241_Fer4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041181">
        <property type="entry name" value="DR2241_middle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18069">
        <property type="entry name" value="DR2241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18009">
        <property type="entry name" value="Fer4_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DR2241" evidence="3">
        <location>
            <begin position="123"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Fer4_23" evidence="2">
        <location>
            <begin position="237"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="392" mass="44483" checksum="3322AA9992BB8F4D" modified="2019-02-13" version="1">MTVSRTHVESLLERADDGVALDGFRLERSEDGDGRYVLETPDQRRPSLDESALEGALESTAEYVTNWSYWQETVGGEGTARRAFLRWCERAPVGETEPTAAGNGDRGITERGTAETEPIRSLPERYDAIRTGISREWGQLSITVSFDDGDDRRGGRVYELRHVDDDGAQREDLEALDEPRDARDIATTDENGRYRPLKTAPTLESGWVFADLAGDDLVEAVDFLYPATIANWHRERRGNLDVDHWLETAERQTGIYDVVDELPREAVEWMAEACCVDSQCLRRREWEYEEDAELDVDGGDGQFPCREPCSLVIAAARKWTILESEDERTYELELTTSEFNQLTELIDAVAEGRTDEVREADVYDGANRYRARYLRAKRFDDGALTARSSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4J0</accession>
    <name>A0A3N6P4J0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92869">
        <property type="protein sequence ID" value="RQG92869"/>
        <property type="gene ID" value="EA462_01195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="32"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="392" mass="43568" checksum="E0D37B29B5D63114" modified="2019-02-13" version="1">MVLELLPMQTTGGALLFIGALVLVVVIAALLSAIEIVDAYEKRALTVFGEYRKLLEPGINFVPPFVSNTYRFDMRTQTLDVPRQEAITRDNSPVTADAVVYIKVMDAKKAFLEVDDYKKATSNLAQTTLRAVLGDMELDDTLNKRQEINAKIRHELDEPTDEWGIRVESVEVREVNPSKDVQRAMEQQTSAERKRRAMILEAQGERRSAVEKAEGDKQSEIIRAQGEKQSQILEAQGDSISTVLRARSAESMGERAVIDKGMDALTEIGQSESTTFVLPQELSSMIGRYGKHLSGSDVKDGDDKLDSLDFNEETRELIGLDDISEIIGEIDQEADMDVEAMEQEAQAIKEGKDPSTISDPEDVIEEMDQDFQEQTDGGIDDRGDAEDTTTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4K3</accession>
    <name>A0A3N6P4K3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_10140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90325">
        <property type="protein sequence ID" value="RQG90325"/>
        <property type="gene ID" value="EA462_10140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="344"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="420"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="482"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="686" mass="75133" checksum="54A6E15AEE1C5800" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4L3</accession>
    <name>A0A3N6P4L3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_01370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92899">
        <property type="protein sequence ID" value="RQG92899"/>
        <property type="gene ID" value="EA462_01370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="303" mass="33166" checksum="7F71C8555BEFA542" modified="2019-02-13" version="1">MRTMATVVRKDFSDSVRSLSLWVATLLLVAAACAVYLFVWGAQDIAGPRLETGILSMTFPLQFLIGLIALLVGFGAIVGERTTGSIKILLGLPPTRRDVFLGKFVGRFLVIAVPIAVTFLAVSVLSLVTYGEVPIADFAPLLLGALLLGAVWTSIAVSFSAVTESRTRVIAACLSVWLVLVVLWEILLTILYYIVEGTFPEAAGPDFVAEPTWVLVLQRLNPIEAFAFLSSEYVEPMILPALFPFFVGEQRWGEYTTAERYHGQEGATEIPFYLEGEFGAVILLAWIVIPLAIGYLRFRSVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4V1</accession>
    <name>A0A3N6P4V1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93029">
        <property type="protein sequence ID" value="RQG93029"/>
        <property type="gene ID" value="EA462_02110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="132" mass="14694" checksum="8621E378F9A40569" modified="2019-02-13" version="1">MAHATERLRRYLEDELEECRSEDVDRRLDELGTLEATIGHERVSDELDVLSALANETRYAIVRVLVAAREELCVCELNAVVDVTESGLSHALSALVEAGLVTARKEGRWRKYRATNRAVALVTVLEGSLEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P545</accession>
    <name>A0A3N6P545_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NINE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_02975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93179">
        <property type="protein sequence ID" value="RQG93179"/>
        <property type="gene ID" value="EA462_02975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="9">
        <location>
            <begin position="74"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG93179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="144" mass="15463" checksum="BBD413AB71E9BFEC" modified="2019-02-13" version="1">MKHCLNCGDQIKAEAAVCPTCGFNQSDTLEGSHEDRAENEKYCVECGATINRQAEICPECGVRQPSASGSGDTDKIAAGVLALLLGGLGAHKFYQGRMKLGVLYLCFFWTGIPALLGLIEGILMLIADDDEYERKYADGGILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P5A0</accession>
    <name>A0A3N6P5A0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93249">
        <property type="protein sequence ID" value="RQG93249"/>
        <property type="gene ID" value="EA462_03390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="68" mass="7576" checksum="72013A3DA9B7D031" modified="2019-02-13" version="1">MIFKCPADISRYRPRPVRPMPTCNHCDAHVSERFARVFADERGDIHACISCSANAGIAEVAKERSRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6B4</accession>
    <name>A0A3N6P6B4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MaoC family dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91285">
        <property type="protein sequence ID" value="RQG91285"/>
        <property type="gene ID" value="EA462_04670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="88"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="215" mass="23357" checksum="5AC9DA77FB750053" modified="2019-02-13" version="1">MSQNTEGNEFAAVTNAWSEMTRSFIRSATAANRAALSAMVPAATENGSNGKSTPASVPSIDHSDLGWTFERTVDESADLDVGDAVTFDKRLTDEDVRAFAQISGDTNRLHLDDGFAVETRFGERIVHGTLVSGLISAALARLPGLTIYLSQDLEFVAPVGIEDRVSARAEIVEDLGNRQYRLETVVRNEDEDEVVIDGEAVVLIDDLPDDDRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6U1</accession>
    <name>A0A3N6P6U1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91595">
        <property type="protein sequence ID" value="RQG91595"/>
        <property type="gene ID" value="EA462_06490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="447" mass="50425" checksum="483B17C9630AED28" modified="2019-02-13" version="1">MGLFDRLRGDGNPRVAFIGVDGVPFSLLSEHEELFPNFAAIAADGTASEISSIVPPESSACWPSLTTGTNPGETGVYGFQDREAGTYDTYVPMGQEVQADRVWDRVHEDGRRATVMNVPVTFPPQRSVQRMVSGFLSPGLDKAAYPDDVRDYLESIDYRIDVNPKLGHQDDKSAFIEDAHATIDARYEAFEHYIEEDDWDLFFGVFMTTDRVNHFLFKDYERDGEYRAEFIEFYRTVDDYIGRIREALPEDVTLIVASDHGFTSLDYEVHFNEWLREEGWLSFETDEPEELGDIATETKAYSFIPGRFYINLEGREPRGSVPEDEYDDVRDELKADLEALEGPDGRNVVERVVEKEAAFRGDHDDIAPDLVAIPTHGFDLKSGFKADSTVFDTGPRNGMHSFDDTALYIDHPDASIDDADLFDIAPTILDLMDVEYSRGEFDGASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P902</accession>
    <name>A0A3N6P902_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-lactate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_00155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92685">
        <property type="protein sequence ID" value="RQG92685"/>
        <property type="gene ID" value="EA462_00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG92685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="564" mass="60202" checksum="694AECFC6277D025" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA24</accession>
    <name>A0A3N6PA24_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase</fullName>
            <ecNumber evidence="2">1.2.1.103</ecNumber>
            <ecNumber evidence="2">1.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysY</name>
        <name evidence="5" type="ORF">EA462_03010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in both the arginine and lysine biosynthetic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:41948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9712"/>
            <dbReference type="Rhea" id="RHEA-COMP:9714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78499"/>
            <dbReference type="ChEBI" id="CHEBI:78501"/>
            <dbReference type="EC" id="1.2.1.103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:52668"/>
            <dbReference type="Rhea" id="RHEA-COMP:13313"/>
            <dbReference type="Rhea" id="RHEA-COMP:13327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:136717"/>
            <dbReference type="ChEBI" id="CHEBI:136761"/>
            <dbReference type="EC" id="1.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.103" evidence="2"/>
    <dbReference type="EC" id="1.2.1.106" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93185">
        <property type="protein sequence ID" value="RQG93185"/>
        <property type="gene ID" value="EA462_03010"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00037"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043870">
        <property type="term" value="F:N-acetyl-gamma-aminoadipyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02083">
        <property type="entry name" value="LysY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037535">
        <property type="entry name" value="LysY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="4">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="24"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="358" mass="37590" checksum="27CF110B42374299" modified="2019-02-13" version="1">MAADAESHADGRADAVTASIVGGSGFTGGELLRLLAGHPHVEVAEVTSRSKAGKSVGSVHPPLRGSDLRFTEPDDMENVDVLFAATPHGVSMGRIDDFFEIADTVVDLSADFRLGTEAQYDEWYDGHDAPEYMEKAEYALPEINRENLEGAELIAGGGCNATATILGLYPLFEHGILEGGEQVVVDVKVGSSEGGAGGGEASSHPERSGVVRPYAPTGHRHEAEIEQFLGTSVAFTCHAVDMIRGASATSHVFPSGPVSKGDLWKAYRGCYEDEPFVRMAAGSSGVYRYPEPKAVAGTNLAEVGFELDPSNERIVVFSAIDNMMKGSAGQAVHAANIALGFEETAGLDFAGLHPVGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHT6</accession>
    <name>A0A3N6LHT6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="3">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">panB</name>
        <name evidence="7" type="ORF">EA462_17090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3 6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86185">
        <property type="protein sequence ID" value="RQG86185"/>
        <property type="gene ID" value="EA462_17090"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="3 5">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5 6">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="270" mass="28707" checksum="B2F3C99E1DDE848E" modified="2019-02-13" version="1">MPTVRDVRAKSGEEPITMLTAYDAPTAEIVDEADVDVILVGDSVGNTSLGYETTLPVTVEDLARHVGAVSRSTEDALVVADMPFLSIGVDEADSIENAGRMLKDEGAHAVKLECGQHTVSLTERMVQLGIPVMAHLGLTPQHVNQYGGYPRQGTDQDGAERILELARAHENAGAFSLVLEHVPSNLAADVTDALDIPTIGIGAGPDCDGQVLVVDDVVGLSAWSPSFSKQFGTVRREMESAIDEYVSAVESGSFPAPEHSHEADDLEDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHZ9</accession>
    <name>A0A3N6LHZ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86699">
        <property type="protein sequence ID" value="RQG86699"/>
        <property type="gene ID" value="EA462_16295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="163"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="297" mass="31064" checksum="E1B9BA75DF9913F7" modified="2019-02-13" version="1">MPVTIDVFLLSILAAALWGLNPVFMKKGLERDGNAILASVVAATVSFGLFVTIATVVYGPSESYLGVSRTGAAIFLFGGVIGSSLGRLVVYAGVDRVGVSVNTAILNTRPLFAAILAVGLLGEPITGWLGLGILVIVVGVVLVSLSRGGDIRGWKWYELAFPLFAAIAYGAGNVVRRYGFTATDTDVLSAFVLNEFAALGILMGYALVRHGRKLFVVSRRTYALFAAGGLLSSLALLSLFTALSRGPVIVVDPLAGTSPLFAALFTVIFLKRVERVTRGVVIGAAVIILGVVFITLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI54</accession>
    <name>A0A3N6LI54_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetamidase/formamidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86779">
        <property type="protein sequence ID" value="RQG86779"/>
        <property type="gene ID" value="EA462_16730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="419" mass="45896" checksum="5F4CF46DDB88034D" modified="2019-02-13" version="1">MPETVFEVDTEAPPDEQPDPIVNRWHPDVPPVASIDPGEKVRIECMDWTGGQVNNDDSANDIRDMALDPNHHLSGPFEVTGAEPGDILIVDILDLGAFPDHEWGFNAIFDKENGGGFLTDHFPEARKSIWELDGVIASSRHIDDVRFPGCAHPGILGTAPSHELLEEWNERERALIERGPDAETAVNHETREEQPPLALPPESNDVLLGGMDDDDAEEAAEEAARTIPPRENAGNCDIKNLGRGSRVYLPVFVDGANFITGDLHFSQGDGEITFCGAIEMAGWVDLKVDVIKDGMEKMGTDYAMFKPGYMDPDFSDYVVFEGYSVDEDGKQHYKNANVGMRRACLDAIDYMTNFGYSEEQAYMILSTAPVESRIAGIVDLPNTCVTVSLPEEIFDIDINPDILADGDATGDRGGVAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIB9</accession>
    <name>A0A3N6LIB9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_15745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87084">
        <property type="protein sequence ID" value="RQG87084"/>
        <property type="gene ID" value="EA462_15745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="8">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG87084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="165" mass="17555" checksum="64EDCE6F77CD9A75" modified="2019-02-13" version="1">MSRTDSYDDTYTESQVIMTSVKIIAPFTLTYGMFMSLHGADTPGGSFQGGAIIGVTVLMLAFAFGIEPTRRWLKNSFVVGLVTGGVTIFIATGLATIALGGNFLEYDAFVDAFGIAHYWGMEAIEVGGVALIVAGVVITLFFATAAGFTPERRSDERLEGVSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIE8</accession>
    <name>A0A3N6LIE8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86949">
        <property type="protein sequence ID" value="RQG86949"/>
        <property type="gene ID" value="EA462_14930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="22"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="216" mass="22681" checksum="52FFDF90F1CF31B9" modified="2019-02-13" version="1">MVTLVETIDWMSSNSDVLIRQSIEHLSIALTALVIGIVLWVPIGILIRNNERVSQVLLGASGIVLTIPSLALLPLLIPFFGIGEAPAIVALVLYSALPIMRNTVVGIAGIDDAIREAGRGLGLTDRQLLVRVQLPMAYPVIMAGIRQATVLLIAITTVAAYFGAGGLGRSIFAGIRLANADQIIGATIVLSALAIVLDYGLAATVKLLPNSEVIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIF3</accession>
    <name>A0A3N6LIF3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86959">
        <property type="protein sequence ID" value="RQG86959"/>
        <property type="gene ID" value="EA462_14980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1252" mass="131257" checksum="3B102BCC252D349F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIN5</accession>
    <name>A0A3N6LIN5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87786">
        <property type="protein sequence ID" value="RQG87786"/>
        <property type="gene ID" value="EA462_13000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="266" mass="29843" checksum="C894D3D908644DA1" modified="2019-02-13" version="1">MNPGRTDDNRRSGGSIVTRLSTASIVTPIRFGRSIRSRRLEYVENTSMARFHPAIAAQTLSLDPSDWDRTFVIGDVHGCRATLERLLDQLGICENDLVVFVGDLVRRGPDNHGVVEIVRSAPNMYSVRGNNEEKIIAATRNVGNLTTDDIDWLRSLPVVISWTETIVVHAGVDPRKPLTDQTVENLLDIDLLNPDDESSPFWWEEYDGSLRIIFGHEPLEEPLIDDTLVGIDTGCVYGGSLTAYDCRNDRAIRTAVDNSEVYDWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIQ8</accession>
    <name>A0A3N6LIQ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_13230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87826">
        <property type="protein sequence ID" value="RQG87826"/>
        <property type="gene ID" value="EA462_13230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="252" mass="27390" checksum="A23E842E518E6989" modified="2019-02-13" version="1">MTLLKTRNLTKDFGGLTAVEEVDIDVQQEELISVIGPNGAGKSTLINLITGMLAPTDGDIVYDGTSITGLDPHEITQLGVGRSFQTASIFPELSVRDNVDIASFASRHGEFSVNFFRRQERYDGVSQRTMDALEAVDLVEEVDTVANSLPYGDKRRLEVAIGLATDPDLIFMDEPTAGMSPAETNMTTDLIEDMRTDWGITVVLVEHDMDIVFEVSDRIFVMNRGSLIASGSPDDIRGNPDVQAAYLGGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJE6</accession>
    <name>A0A3N6LJE6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88041">
        <property type="protein sequence ID" value="RQG88041"/>
        <property type="gene ID" value="EA462_14415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="410" mass="42814" checksum="11D9073FD966C3AB" modified="2019-02-13" version="1">MDDNDRSVVGVVMLSHALVHTYELTIPIFMVVWLVEFSATEALLGVVVAVGYALFGIGALPSGVISDKYGSQNLIAVCLVGMGLSFIILSFATNILMIAVAVCLWGAAASIYHPAGLSLISTAVKDSGSGFAYHGMAGNAGIALGPLCSVVLLWFTDWRAVSLVLAIPAFFAVVYILRADIDEMAAANLASDGSGGTGGPADAPSSPSFFESSKSLFLGGFALVFLVIVFNGLYYRGILTFLPELLADFVTIGGLEDGAGAEQFDGSDFIYVGILMVGILGQYVGGKATDRIPVERGLVAGYACLVVIALLYVPAAESGLIFLVFVSLLLGFCLFALQPMYQVAVAEYSPTDSRGLSYGYTYLAQFGVGAMGAAIVGIILTYSVVASVFFALAAFAVVASAFSVRLLMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJR0</accession>
    <name>A0A3N6LJR0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88973">
        <property type="protein sequence ID" value="RQG88973"/>
        <property type="gene ID" value="EA462_11325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012015">
        <property type="entry name" value="UCP_HTH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004955">
        <property type="entry name" value="HTH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="259" mass="26922" checksum="F31F7CBA5EE08F1B" modified="2019-02-13" version="1">MVDVLDNKRAATRFRILVQIAERQPAVSQGEIAGEVGVTSQAVSEYIRDLVEEGLVEKEGRSRYRVTPEGVDWLFGAAEDVRRFADHVTGDVLGAMSEDAAIATGDIDEGDTVSLTLQDGLLHATPGEEGPATGIATTDAEAGTDVGVTSFEGVIELEPGAVTVLQVPTVRTGGSRTVSIDTVSEVCADADLVVATGVEAVVACRRANADSDVRFAVGDVAADAAERGLEVTAVVTTDAVGRVTDSLRDADVSHEVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJY2</accession>
    <name>A0A3N6LJY2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86658">
        <property type="protein sequence ID" value="RQG86658"/>
        <property type="gene ID" value="EA462_16050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="178" mass="19407" checksum="780069A7BD4A7C9C" modified="2019-02-13" version="1">MWPLGHAAIAYLCYTVSTRARFDSPPAPLPVLIVLFGSQFPDLVDKPLAWYLGVLPTGRTLAHSLLLLVPLSLAIYALARHAGRAEYGIAFAIGAISHALVDALPVLWGGTSADFLLWPLIPVESYESGAPTILGLLFDSLGDPYFLSEFVIAALAFVMWRRDGYPGLEIFSRPRSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLK6</accession>
    <name>A0A3N6LLK6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tat pathway signal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89883">
        <property type="protein sequence ID" value="RQG89883"/>
        <property type="gene ID" value="EA462_07675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="428" mass="47224" checksum="0E567EE0677F2168" modified="2019-02-13" version="1">MTLSDRSSLSRREYVRSLVAAGGVSALAACLDAVDGDGASGATDVPTGTDDPDSLPERQHAWNDALSSDDDGNVALPEHHVLVALSLVDHPDETSRETVERAFETLERAYEWSNEGLVFTIGYTPSYFERFDDPVPDSVDLPEPAALTDRESPTFDEFDALFHLASDRPSVVLEAEEGLFGECETVNDVSVETGLSDVFERLEDDRRTGFVGDGLPAERTDVDGVPDSVPEEAPFFMGFRSGFRESQATEDRVTITEGPFAGGTTQHVSSMDIQLEVWFDQENHYQRVSKMFSPEHAEREMVGDHGERLGATSELSDERIEATEADARERGVVGHAQKAARARENGDPLLLRRDFNTVDDGPGLHFVSLQREISEFVRVREAMTGADLDVPFANNGIRHYIFIDRRGNALIPPRSLRSLPPANPTRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLL1</accession>
    <name>A0A3N6LLL1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_07735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89893">
        <property type="protein sequence ID" value="RQG89893"/>
        <property type="gene ID" value="EA462_07735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="6">
        <location>
            <begin position="63"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="268" mass="29091" checksum="7C4E26D0636CC018" modified="2019-02-13" version="1">MSEDPEPSMNISGGESGGGIATEFDPSTAETRAERVIDRLGELYWQKTYGGQDAFTCLVRTILSQNTSDKASQPAHDDLLERYGGGNVDLAESLASAERSELAETISSAGLYNQKSEVIIETAEWVREQFGSARAFDAFVKDEEPETVRETLLSVRGVGPKTADCVLLFAGGRVGIFPVDTHVHRIYRRLGIAPADADHEGVRSVLEREVPASKCGFGHTATIQFGREYCRARKPACLEDPDACPMGDLCDQVGVYPETNEIVDPSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLN5</accession>
    <name>A0A3N6LLN5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TlpA family protein disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89923">
        <property type="protein sequence ID" value="RQG89923"/>
        <property type="gene ID" value="EA462_07890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="47"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="199" mass="21096" checksum="72DAAAFF5945DB43" modified="2019-02-13" version="1">MNRRELVAGIGSVVLLAGAGGVMWRGLPAFADPADGSSDLEDAENQEKSGETDGSLEVPTIDANGSEAGALTVPDRRATVATFFVTGCGQCQAQMPRLAEAHSTLEERHGDDVAVLSVTYQTPETMPENELREWWADLGGNWSVGYDPSPSLAATYGAVGYPVTIVVDENGEKHWHENGVQRANRIVRAAESVLEAGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLX0</accession>
    <name>A0A3N6LLX0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose 1-dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89918">
        <property type="protein sequence ID" value="RQG89918"/>
        <property type="gene ID" value="EA462_07865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="254" mass="26564" checksum="6C626F5CB902F835" modified="2019-02-13" version="1">MTRFDGTTAIVTGGGSGIGEHTARTLATDGANVVIADVDSENGEATTAEIVDETDSDATFVDVDVTNDDDVEGMVETALEEYGGLDIAVNNAGIGSKLEPTAAVSESDWQRTIDVNLTGVWRCLRSEIDAMVEDDGGAIVNTASILGRVGTQGAPAYTASKHGVLGLTKVAALDYASEDIRVNAVCPGYIDTPMLEEAGLYEDEATVEQLRELHPQGRLGEPQEIADAIAWLCSDEASFATGEAMAIDGGYLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM04</accession>
    <name>A0A3N6LM04_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative nickel-responsive regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_08830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Transcriptional regulator.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="8">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90093">
        <property type="protein sequence ID" value="RQG90093"/>
        <property type="gene ID" value="EA462_08830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010045">
        <property type="term" value="P:response to nickel cation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00476">
        <property type="entry name" value="NikR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022988">
        <property type="entry name" value="Ni_resp_reg_NikR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0533">Nickel</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHH_1" evidence="9">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="NikR_C" evidence="10">
        <location>
            <begin position="54"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG90093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="142" mass="16265" checksum="1628DCC7648EA626" modified="2019-02-13" version="1">MAVVSVSMPDELLDRLDEFAQEHGYTGRSEVVREASRNLLGEFEDTRLEERDLMGIVTVLFDYETTSVEEQMMHLRHEHEELVASNFHSHVGDHYCMELFVLEGQLEDISTFVGKIRATKDALTVDYSVIPVDDFDPISQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMB8</accession>
    <name>A0A3N6LMB8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90223">
        <property type="protein sequence ID" value="RQG90223"/>
        <property type="gene ID" value="EA462_09570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="146" mass="16834" checksum="7548B21873E0F8DE" modified="2019-02-13" version="1">MTVRVDRSFELRASPERVWEFIADPANRARAISVVDRYTTTGPDGRETTWHVELPIPFVRRTVAVETEDVVRRPPEYVKFVGRSNVLKVTGEHRVSETATGARLENHFVVDGKLPGVETFFKRNLDDELENLRRALERDLRTAEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMI6</accession>
    <name>A0A3N6LMI6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carboxyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_11635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89027">
        <property type="protein sequence ID" value="RQG89027"/>
        <property type="gene ID" value="EA462_11635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="14"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="300" mass="34308" checksum="E3DF367D3F26CC41" modified="2019-02-13" version="1">MANERITPDDLPEPRYEYGADDHVFVELAEAMSFTANVKAMAITQQVAEREIDGVIENCPANASYMLRIDPEVIHPDDLIAQLREIESDLDLTEYEWDTRLIDVPVLFQDPWTHETLMEFRDRHQDADATDLEYSAQINGYDSVEAFLDAFVGAPHMVTMVGFVPGLPWCFQMVPRSEQLEVPKYVEPRTDTPSRAVGFGGAFSVIYPVQGAGGYQLYGRTPIEVLDVDQILPDFRDSMVFPNPGDILNYRRIDRDTYDEIRESVEAGEYEYTYQRVSFSPDEFFESPHEYTDDLTAVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMJ0</accession>
    <name>A0A3N6LMJ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tfx family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89037">
        <property type="protein sequence ID" value="RQG89037"/>
        <property type="gene ID" value="EA462_11695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029291">
        <property type="entry name" value="Tfx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004645">
        <property type="entry name" value="Tfx_DNA-bd_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018384">
        <property type="entry name" value="Tfx_DNA-bd_euryarc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036657">
        <property type="entry name" value="Tfx_DNA-bd_sf_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14601">
        <property type="entry name" value="TFX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004932">
        <property type="entry name" value="DNA_bind_Tfx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89915">
        <property type="entry name" value="SSF89915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00721">
        <property type="entry name" value="tfx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="TFX_C" evidence="2">
        <location>
            <begin position="66"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="152" mass="16342" checksum="CD358A3DA9B06C4D" modified="2019-02-13" version="1">MIDDTEELLEEIGFEPETSVLTHRQAQVLALRERGISQADIADALGTSRANVSSVEASARENLEKARETVAFAEALRAPVRVRVSSGTDLYDVPQLVYEACDEAGVKVDYTAPNLMKVVSDAAGSAVSGRQVTTPLIVGVTSDGMVRVRHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LML6</accession>
    <name>A0A3N6LML6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90288">
        <property type="protein sequence ID" value="RQG90288"/>
        <property type="gene ID" value="EA462_09935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="160" mass="16964" checksum="DCA4D55A928815D7" modified="2019-02-13" version="1">MRDTLTRDERGLSTAVTHVLTMGITTVLVAGLLVSSGTLIDHQTDRSAEQSLETIGERLAGEITHVDRLASDGDSVTVIATHPRTIAGSTYRVGIEDSRTCAGEPLLDGSTVCLRLSSTDADAEVFVPISNESELNSESLVTGGTIEIEHNGTTNEIELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMS3</accession>
    <name>A0A3N6LMS3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89137">
        <property type="protein sequence ID" value="RQG89137"/>
        <property type="gene ID" value="EA462_12255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="15153" checksum="D0B00DEE8E65801B" modified="2019-02-13" version="1">MSSAGSSSNAEQSSSRRQLALFLALVLLGSSLFVRTPAFLPGRTAMGVMGIFAVIAVVLLWRRSAAASEAGSTDRSDGDRERQSDAERAADGDSSVWNAIPSWQYEGRHVESGGLARSEQERALEDVRQQAAELSEEPPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP53</accession>
    <name>A0A3N6LP53_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltranf_PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89867">
        <property type="protein sequence ID" value="RQG89867"/>
        <property type="gene ID" value="EA462_07580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027391">
        <property type="entry name" value="Nol1_Nop2_Fmu_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13636">
        <property type="entry name" value="Methyltranf_PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranf_PUA" evidence="2">
        <location>
            <begin position="127"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="182" mass="20824" checksum="7838A04F2AAC1D2C" modified="2019-02-13" version="1">MTDGDRADAEDRDADRKSNDGQRFDRLPATEAERTVEGRASRREVLEYVDDRFGIPPETFDDYTFWEKGAGKIWIYAGEASSPLEIEAIGMTCLRTRQEHWKPTTDFVQRFGRHAQTCVIELDPEAARRFVAGEDQELEWDGDWGYLVVGHELAGDLEPIGVGMYVHGELRSMMPKGRQRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPA0</accession>
    <name>A0A3N6LPA0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89937">
        <property type="protein sequence ID" value="RQG89937"/>
        <property type="gene ID" value="EA462_07970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="332" mass="34645" checksum="EF5927B975016CF9" modified="2019-02-13" version="1">MTDTLFLTSSDVADLATPAEYVDAVRAGYRQRGNGAPAKPRSKFFRSDPGGMLTSYAAVLPETGAMGGYMYSAGFGAEDAWFMTPLFDATSGAPLALLDGASMNPFKTGAAGAVAVDELAREDADALAVIGSGAQARGQLRTTATVRAFSDVRVYSPTADHRESFAADFDDQLEATVRAVDSSTAAITGADVVITATRADDPVFDGSKLEAGTHVTAMGQYAPERCELDTTTIERATYVPDLRERATFDAGSFLAALDAGVVTEDHIHAELGEIVAGNARGRTSDDEITVFDSGGTGIETVAAAYMLYEKARAEGIGTEIAFEPASEALTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPE4</accession>
    <name>A0A3N6LPE4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR00270 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89997">
        <property type="protein sequence ID" value="RQG89997"/>
        <property type="gene ID" value="EA462_08295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004451">
        <property type="entry name" value="CHP00270"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00270">
        <property type="entry name" value="TIGR00270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="97"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="179" mass="19042" checksum="0A04B74C1A11F818" modified="2019-02-13" version="1">MVQCEMCGAETSSPKTIKVEGAKLDVCSNCTDFGTEVKQPTSSTASTKYSTGSSSGESSGTSNSQSASSSSSGGSSSRRKDMFDDMDELVTDYDDRVRNAREKKGISQSDLANELNEKASLIRKIERGDTLPSDRVQSKIERFLEIDLSAEGGSADDAEWSGGSSSGSYTLGDVVKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPK1</accession>
    <name>A0A3N6LPK1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88794">
        <property type="protein sequence ID" value="RQG88794"/>
        <property type="gene ID" value="EA462_10335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="541" mass="59997" checksum="A124E8B94EACD438" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPL7</accession>
    <name>A0A3N6LPL7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90107">
        <property type="protein sequence ID" value="RQG90107"/>
        <property type="gene ID" value="EA462_08910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="167" mass="18383" checksum="C80797120440A670" modified="2019-02-13" version="1">MRSETTSRARVERERFFVLPVDYSRVAPDRAENEPEEYDPEAEFRDPDSDSITIPRVPTEDAGSTLRADLAAEFGNGTPEIPDSLPEPSEVPADLRRTFWVIVLVVNAAVLAVSLGLILSLFNGLSTHGIALVVGGVVLFALAVRRYHNYQAANDTSEQIPDESERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPU0</accession>
    <name>A0A3N6LPU0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91533">
        <property type="protein sequence ID" value="RQG91533"/>
        <property type="gene ID" value="EA462_06120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="112" mass="12453" checksum="58DE1E24FF541753" modified="2019-02-13" version="1">MRTFGAQRRRRPYAVGSRPHYRRGTGVLAEIAAPSEEDEQTDGRTPRCEGIADLRIRHAVERHETGEVSTNEAARIAAVSAAEWLEIARERGLTTQLSPDALESDVRSARDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPZ1</accession>
    <name>A0A3N6LPZ1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps10</name>
        <name evidence="7" type="ORF">EA462_11380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88984">
        <property type="protein sequence ID" value="RQG88984"/>
        <property type="gene ID" value="EA462_11380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_S10_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="6">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG88984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="103" mass="11613" checksum="E1B88EFD145EAC66" modified="2019-02-13" version="1">MQQARVRLAGTSPDDLDDICDDVREIANNTGVNLSGPIPLPTKTLEVPTRKSPDGEGTATWEHWEMRVHKRLIDLDADERALRQLMRIQVPNDVSIEIVLEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ30</accession>
    <name>A0A3N6LQ30_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89024">
        <property type="protein sequence ID" value="RQG89024"/>
        <property type="gene ID" value="EA462_11620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="60" mass="6374" checksum="7B9E86256BD2363D" modified="2019-02-13" version="1">MYVHHKFAYSLGDPARRASVDVCTRSRDASRDDGKLFGFATGEGRFAAGKGYAASISTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQE0</accession>
    <name>A0A3N6LQE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89174">
        <property type="protein sequence ID" value="RQG89174"/>
        <property type="gene ID" value="EA462_12470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="508" mass="51147" checksum="7CCD2D3C295F2869" modified="2019-02-13" version="1">MARKNRRNRTGSSGLSRRSALALIGGGGLIGVGASGAFDAASVNRPFGLPVRSDDEALLGIDLYDPTASSGSEVRILQLYNGFSETLTTVSVSTLSTGGITLDIDDPLVSGAFEPNQRIPVYATISCGEERTESVDLEIVVEGETERVAATRSIDVTCQRAESDPIPACDLGPTGGETAVSLRGNDSEDELSGELDVTMSGSTSVAGNVDVTGDVDLDGNSQIAGDLIAGGSVTLEGSATVDGDVVVGGSLEMSGGAQVGDGAAAIEVCGDASFSGGGGSNLGIDTLTVGDDLDVSGGYRIDAEGDIVVNGSVHWNANQLTTTGGDLSVGGDLSVSEGAKLEIDGDILVDESVAMNGNRLETTAGDLSVGDDLEVSNGRTEIDGDVLVDGALEMNGNRLESTSGDIVVEDDVAANGGTLAVGETGLIDVSGAFGMTDGWAVTVGDVTVGESLDIDTGEMTASGDTVTVAGDLNMGHGQGYPEIEADVVIGGSLNKDRGSIQGTITYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQK4</accession>
    <name>A0A3N6LQK4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89264">
        <property type="protein sequence ID" value="RQG89264"/>
        <property type="gene ID" value="EA462_10505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="181" mass="21116" checksum="C4030A95680A3506" modified="2019-02-13" version="1">MPRPEVAMRSRDELFTVLSNRRRRRVLYYLLQHDVKQVDLRTLVDVLSEWEYGESVDDLSWKQRKRVYTALHQSHLPKLAEAGAIEYERSRGQVTPTEEIGEYRIYLEYVPADDIPWYRYYLGLTAIAATLTGLVWLSVFPFSNLSGLALSTILVSVFAVSAIVHAHHSRWNQIEMSELFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRW6</accession>
    <name>A0A3N6LRW6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriocin biosynthesis protein SagD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89944">
        <property type="protein sequence ID" value="RQG89944"/>
        <property type="gene ID" value="EA462_08005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027624">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03604">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="235"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="586" mass="61883" checksum="B820DE26BB878022" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSA6</accession>
    <name>A0A3N6LSA6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YeaH/YhbH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91417">
        <property type="protein sequence ID" value="RQG91417"/>
        <property type="gene ID" value="EA462_05445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006698">
        <property type="entry name" value="UPF0229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30510">
        <property type="entry name" value="PTHR30510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04285">
        <property type="entry name" value="DUF444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="439" mass="50096" checksum="B130AB868E880C66" modified="2019-02-13" version="1">MGLRDDLERFREVGEQRREDLAEFIQYGELGSSRPGEIKIPVKIVSLPEFEYDQRDKGGVGQGDGDTPDVGQPVGQPRPGDGDEDGEPGEEGGDHEYYEMDPEEFAQELDEELGLDLDPKGKTVVEEKEGPFTDLTRSGPDSTLDFERMFKEGLKRKLAMDFDEEFVREVCKVDGITPRDVFEWARGENLPVSMAWIETTYAEIPDGERGTWSSIEDVERNVDRESVQQKIRREGIKHVPFRREDERYRYPEIIEEKEKNVVVVNIRDVSGSMREKKRELVERTFTPLDWYLTGKYDNAEFIYIAHDADAWEVEREEFFGIRSGGGTKISSAYELASELLEAYPWSDWNRYVFAAGDSENSSNDTEKRVIPMMEEIDANLHAYVETQPSGNAINATHAEELERYFGTDTDDVAVAYVNGESDVTDAIYETLSTEGETDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSM8</accession>
    <name>A0A3N6LSM8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91527">
        <property type="protein sequence ID" value="RQG91527"/>
        <property type="gene ID" value="EA462_06080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="157" mass="18318" checksum="D3765B5C467CED85" modified="2019-02-13" version="1">MIRGGDWDLKAKPFEESPKYRYISEFAERDCPPPERTEVVPEWGKSEQYLIEFERLYESIQTDGFQTQSELPDGGGVVNEINICIGRDGTMIVKHGYHRVAIAKVLELDAVPVYVRVRHEDWQRHRDEAWEADSVKQLSAETRRHISHPDIRQALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSQ8</accession>
    <name>A0A3N6LSQ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacterio-opsin activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93003">
        <property type="protein sequence ID" value="RQG93003"/>
        <property type="gene ID" value="EA462_01975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="213" mass="22651" checksum="03E51041814C2F60" modified="2019-02-13" version="1">MTGFRATVVVHEPTDCPVASVSAASDDSIGSVNWTRASDGVTVEEFDAPRATALEDATLDVEVTRLRSDGDGGVYRFERERDDCACEVVEGLGTPISSVRAQDGSLLISFRTGDLEEVAVVVEGLRDRFEGVVVEELTRGAAGAGGDRAIVDLDALTPRQREVLETAHEMGYFAYPKGANATEVAEELGVARSTFSEHLAAAQTKLMAAVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSZ4</accession>
    <name>A0A3N6LSZ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93113">
        <property type="protein sequence ID" value="RQG93113"/>
        <property type="gene ID" value="EA462_02600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="397" mass="43868" checksum="9544F6C04EC8FA0E" modified="2019-02-13" version="1">MSHDGRILEGVNVVDLTTFVTGGFCSLMLANQGADVVKVERPGMGDDNRHSGPPFIDGESPYFWTVNYGKKSVELDLKSETGRKALYDLAGEADVFLQNYRPGTAARLEVDEETIRSYNDDIVYCAISAFGQTGPWRERPGYDLMIQGMSGIMSITGEDDGRPVKVGLPTTDLITGMWAAFGISNALYRRELTGEGEYIDLGMLDAALPWLTKQAGKVFAGESPSRMGTKDPVLAPYQTFETADGYLNVACLNQKLWRGLCEAIDRPELADDDRFETNGDRVEHMDELEAELESTFRDRTTDEWMTTLVDEAGIPAGPVADVEDALYNEQTEARDAVTTIEDPDRGTIPVIEHPLNYDRAESGFESPPPRLGEHTRSVFEALGYDEDELEALEAMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT96</accession>
    <name>A0A3N6LT96_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="9">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lpdA</name>
        <name evidence="12" type="ORF">EA462_03495</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93268">
        <property type="protein sequence ID" value="RQG93268"/>
        <property type="gene ID" value="EA462_03495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="11"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="360"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG93268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="482" mass="50445" checksum="66BA27A6C218BA38" modified="2019-02-13" version="1">MVVGDVTTGTDVLIVGAGPAGYVAAIRAGQLDLDVTLVEKDAYGGTCLNHGCIPSKALITATDVAHEAANAEEMGIHADPAIDLSGMVAWKDDVVDQLTSGVEKLCKANQVNLLEGTATFADENTVRVSHDGEGQGSETIEFEHAIVSTGSRPVEIPNFDFDDDPVLDSRQALSLTSVPDSLVVVGAGYIGMELASVFAKVDTDVTVIEMLESILPGYDDDLKRPVKQRATELGIEFEFGYTAAEWREADDGVRVVAEPADRTAGDDEEPDPLELEAEAVLVAVGREPVSDTLDLEAAGVETNDRGFIETDSRARTNVDHIFAAGDVAGEPMLAHKGSMEGQVATEVIAGEPAAIDYQAMPAVVFTDPEIATVGLTETEAKEAGFDPVVGQFPFRASGRALTTGDAEGFVSVVATESKGYLLGASIVGPEASELVAELGLAIELGATLEDVASTVHAHPTLSESVMEAAENALGRAIHTLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUT5</accession>
    <name>A0A3N6LUT5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps8</name>
        <name evidence="6" type="ORF">EA462_05100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91354">
        <property type="protein sequence ID" value="RQG91354"/>
        <property type="gene ID" value="EA462_05100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_A">
        <property type="entry name" value="Ribosomal_S8_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="130" mass="14082" checksum="A529EDACC99883BB" modified="2019-02-13" version="1">MTGNDPLSNALSGLDNAESVGHLSHEVTPASNEIGSVLEVFYDRGYIDGFEYVDDGKAGQFEVELKGAINACGPVKPRYSAGAEDFEKWEKRFLPARDFGALVVTTSNGIMSHYEAREQGIGGQVIAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUU4</accession>
    <name>A0A3N6LUU4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_05150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91364">
        <property type="protein sequence ID" value="RQG91364"/>
        <property type="gene ID" value="EA462_05150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="9470" checksum="E524C734410B0655" modified="2019-02-13" version="1">MADVRTYALIYVVLLALGTGKFAFFEFFTYEIALAATIVLAVAKILLIAGYYQHLIEEPRSITYMMGMAVFMVFLLTVAAGYSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUZ0</accession>
    <name>A0A3N6LUZ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein FxsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fxsA</name>
        <name evidence="3" type="ORF">EA462_05540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91434">
        <property type="protein sequence ID" value="RQG91434"/>
        <property type="gene ID" value="EA462_05540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="202" mass="21582" checksum="6B8B0CFEF5AB0381" modified="2019-02-13" version="1">MLRWIFALLLIPFLDAVILAIVVSQTTYIGWVGMVLLVVLTGLIGMLLVRAEGRRTLRKMQRSLAAGKPPTNELLDGGLLIAAGAFLLTPGLVTDAIGFLLVLPLSRIPIRAGLKRYVIVPYADKKTAGFASGTVWTYGFPEGDRSEDSATTANDGTYDLGEDAYSVDSTGGDSYTIDFGDESSTGSSSSEDGTDDRDPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVK3</accession>
    <name>A0A3N6LVK3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Box A-binding protein</fullName>
            <shortName evidence="5">BAP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">TATA sequence-binding protein</fullName>
            <shortName evidence="5">TBP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">TATA-box factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tbp</name>
        <name evidence="6" type="ORF">EA462_00610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006671604.1">
        <property type="nucleotide sequence ID" value="NZ_REFY01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92767">
        <property type="protein sequence ID" value="RQG92767"/>
        <property type="gene ID" value="EA462_00610"/>
    </dbReference>
    <dbReference type="GeneID" id="40263726"/>
    <dbReference type="GeneID" id="56034431"/>
    <dbReference type="GeneID" id="63187075"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04518">
        <property type="entry name" value="TBP_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033711">
        <property type="entry name" value="TBP_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="PTHR10126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="1" evidence="5">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="186" mass="20330" checksum="D1E5E16C0BBD3AC2" modified="2019-02-13" version="1">MTDPKDTINIENVVASTGIGQELDLQSVAMDLEGADYDPEQFPGLVYRTQNPKSAALIFRSGKIVCTGAKSTDDVHESLRIVFDKLRELQIQVNEDPEIVVQNIVTSADLGRNLNLNAIAIGLGLENIEYEPEQFPGLVYRLDEPEVVALLFGSGKLVITGGKKPEDAEHAVDKIVSRLEDLGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY03</accession>
    <name>A0A3N6LY03_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_17000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86168">
        <property type="protein sequence ID" value="RQG86168"/>
        <property type="gene ID" value="EA462_17000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="246" mass="28172" checksum="15F57C7EE8C1E18F" modified="2019-02-13" version="1">MGAVRRALRNVDVTPTEAMDILSWAQDELPAIYERDQTAYLVLGSYRSPYIRRVRSVSDRLNRRYGTYAFLIGDLDDIDVSRLPEFRVKFHLTAALADYITTVIEQDAGGEINELGKLSETEYFRKAYVLPRGYRWDTESNLRDREDVLAAAAQIETATGADEETKQSELSKLVDRATAAGIDVTVEGLTEWLVDHDLAVPSYSWVQLNDFRLFELQDRCCPWLTEDELVERTDELPGSPRPQWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYC3</accession>
    <name>A0A3N6LYC3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske (2Fe-2S) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_15015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87121">
        <property type="protein sequence ID" value="RQG87121"/>
        <property type="gene ID" value="EA462_15015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="30"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="15183" checksum="AA761F844E142DDB" modified="2019-02-13" version="1">MGVRMRLTTVETIHEEGSWLCTVRDQHGTDEEVLLVPCGDGVEAWINRCTHESQRLDTGTGAAMRDGQIICPKHGSMFDSCTGYCDNGEAAETTLPSIDVIVEDGTVYLTDDDVTYLRDGGIEGGDADGDDDPSSTSHLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYI8</accession>
    <name>A0A3N6LYI8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Indoleamine 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86802">
        <property type="protein sequence ID" value="RQG86802"/>
        <property type="gene ID" value="EA462_16315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="PTHR28657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="386" mass="43561" checksum="1B0CD3DA66D1A860" modified="2019-02-13" version="1">MAEAKLDESIDNQRGFLPTPDPLTSFNTDQYDSMTSEYLQRLDQVGDNLPDLIESGEVRPVLRSLEKPPAGLLDKLNDREMIRLCQLSGFFASAYVNYGQLIGEDDSVLPAGMAIPLYETSEEIGRKPILSYDLLCLHNFQRKDPDGDLSVENLDLIQSFTHHDDERWFVIIHVAIEAAAGPAITACSTAQQAVREDDPELLLRKLHTIEESLVEQTSIMQRMTEGNDTSVFANEYRPYYYGFDEIIFEGVNELEGTPQSLRGGSGAQSSILPSIDATLGIKHDATKMIEKLDDMRSYMPPFHRNTITELDTGPDIKEYVAKQGSDELRRAYNNCITNLITFRKVHFRQISQYIREETGDTTGTGGTNYAYYLQKMKEETEAARID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYX3</accession>
    <name>A0A3N6LYX3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Restriction endonuclease subunit S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_02445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93084">
        <property type="protein sequence ID" value="RQG93084"/>
        <property type="gene ID" value="EA462_02445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="34"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="280"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="463" mass="51969" checksum="DA583D5BE0A651DE" modified="2019-02-13" version="1">MSEQRTLDEISEGTSIESDEVRSSLDETSLGEIPKDWQQVRLKDVIHESNYGAAESAEDFDPGNPRYVRITDINTRGRLKSHTKVSLSKEKADGYLLKKGNLLFARSGASVGKTYLYRQQDGDCVYAGYLINHHINTDLANPEFLYQYTDSPNYDSWVARIQRTGAQPNINAQEYGNLLIPYPPLPEQRKIATILYTVDQAIEKTEEIIDKLEMVRRGTEQDLLSRGILEDGSLRSEENIEYKSSWVDEVPEDWVVQPYSELISDSSVGIVVKPTQYYDEAGEVPILRSKDISRDGIVNGDFEYMTQESNEENSNSQLEAGDVITVRSGEPGLSCVVSPEFDGSNCADLLISTPGDNLDPHYAAMWINSRAGRKQIDRFQAGLAQKHFNLGALRKLRVAVPPIEEQQRIVESVSSITESIDREHQYKTRLQCLKQGLMQDLLSGTVRTADTNIAVPDEIAQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZC3</accession>
    <name>A0A3N6LZC3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93264">
        <property type="protein sequence ID" value="RQG93264"/>
        <property type="gene ID" value="EA462_03470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="80"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="171" mass="18434" checksum="4505D46CA30440AE" modified="2019-02-13" version="1">MAFSTTPDWFHLGDDEEIVWESRPHPIELGVAFPVAVVLVVLGLGVTAWGLSDERGVVTGVGIVLVLGGGATAAVRYLFWTNTRYVITSSELYKKRGVISRDVTQFRLERVQNTSLSQSVLGRTLGYGDLTVYTAGSGDPELTFEHVPRPEHASSILSDQLALSSAGESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M048</accession>
    <name>A0A3N6M048_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ribosome biogenesis protein Nop10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nop10</name>
        <name evidence="8" type="ORF">EA462_11310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88970">
        <property type="protein sequence ID" value="RQG88970"/>
        <property type="gene ID" value="EA462_11310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00803">
        <property type="entry name" value="Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023532">
        <property type="entry name" value="Nop10_arc-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="SSF144210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG88970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="6792" checksum="3391958E831FCB00" modified="2019-02-13" version="1">MKSDIRVCSAWRDRHERPVYSLSSTCPVCDADTENSAPAPFDPTDAYGEYRRALKRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0A6</accession>
    <name>A0A3N6M0A6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89040">
        <property type="protein sequence ID" value="RQG89040"/>
        <property type="gene ID" value="EA462_11710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="234"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="426" mass="46119" checksum="434D493FD6EEAC52" modified="2019-02-13" version="1">MEVQFLGGAREIGRSAILVDDRLLLDFGMDSGNPPSFPIGDVDPEAVIVSHGHLDHVGSLPSLLSGDGRPPVHWTPPTRDLAMVLARDTLKLHGGTYDCPFTEAELARLTQVSETHGYREPFEAAGYEITFFDAGHVPGSAHVLIEDNGFSSGRPGADGGTRLLYTGDFHTGDQQLLAGTTARPNADVVICESTYADTARRPRAEIEAGFAESLRTTIWEGGTVVVPAFAIGRTQEVLCLCEEHDLECYVDGMGKRVTELFLRAENRAFLRDPDLLRRAKGNARFVDGRDGQRKRIAAQNTVVVTTSGMLHGGPAMTYVPEIRSHPVNKIAMTGYQVEGTPGRDLLETGSAEIDGRVMPVSAQVEQFDFSAHADRTGLRSFLESYRNDTVLVNHGDRCEAFAAELRADGFDASAPELGARLEVGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M275</accession>
    <name>A0A3N6M275_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89900">
        <property type="protein sequence ID" value="RQG89900"/>
        <property type="gene ID" value="EA462_07770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="216" mass="24810" checksum="59174F74AED20867" modified="2019-02-13" version="1">MEYELLGWPPDGPTLRLDYERFSYAGKFVMSNTGKAVARTEDDEASERLDLNGDTDGERDHDVGRIVAAAAFNEDRTDDETLWIRYVTVDRAHRGDGIGPKLLSLVRERALKRGYDRLRIAVNNPFAYEALYRTGFVYTGETTGIAELLLEYPSPLELDERSGDGVADSQSRHKDVRFERYQAGLEEFRERDLSEAEERFLEDRRERTPPNPRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2D1</accession>
    <name>A0A3N6M2D1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89281">
        <property type="protein sequence ID" value="RQG89281"/>
        <property type="gene ID" value="EA462_11650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="162" mass="17016" checksum="6B3F41FD6D17FAFB" modified="2019-02-13" version="1">MTTHEITLTVNGTKRELSVEPRTLLIHALRDHLGYTGPKVGCESSLCGACTVHVDGKAVKSCTLLAVQADGADVTTVEGLGAADELHPLQAAFQDEHGLQCGYCTPGVLLSALALLESEPDPSRTEIRAALEGNLCRCTGYQNIVDAVETAADRMPAAEGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2T8</accession>
    <name>A0A3N6M2T8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoacyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_09120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90140">
        <property type="protein sequence ID" value="RQG90140"/>
        <property type="gene ID" value="EA462_09120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PTHR12649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="112" mass="11771" checksum="5736BE88EE387A95" modified="2019-02-13" version="1">MKQAIVARTDIGMGQGKLAAQVAHASLSASEKADSQLRDQWKRNGQKKVVLKGDSERQLHELSAIADSEGIPNALVRDAGHTQLEPGTVTALAVGPAGDDRVDAVTGELSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3L0</accession>
    <name>A0A3N6M3L0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="9">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cysS</name>
        <name evidence="11" type="ORF">EA462_07165</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89791">
        <property type="protein sequence ID" value="RQG89791"/>
        <property type="gene ID" value="EA462_07165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="10">
        <location>
            <begin position="376"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="288"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG89791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="510" mass="57258" checksum="03C6ECCDE24CCF0C" modified="2019-02-13" version="1">MTLHVTNTLTGQIERFEPQDPENVLLYYCGLTVSDPPHLGHARSWVHVDVMHRWLEYLGYDVRHVENFTDVNEKIVARVGEDDLGGDEADVAETYIERTIADMRSLNLLRAEVYPRVSEHVPEIVDLVETLIEKGYAYESNGSVYFDVASFDEYGTLSNQELEEIESQGEPDERSEKRHPADFALWKAGGVDEDAVREHRHECVDHGGEPPTGQTWDSPWGDGRPGWHIECSAMSMTHLGETLDIHVGGRDLVFPHHENEIAQSEAATGRRFANYWLHCELFQMDDEKMSSSLGNFVTVEEAVSNWGTNVLRTFLTAGSYNSKQLYSDETIAEAEERWGHLERGYESAVETLDSADARTNVEDDGLRTAVSIARDEFTAAMNDDFNTREAQSALLSVATAINRHLEDGPISDSNGESRDEYRGFDYRGLRRAVETLEELGNVLGLSFVGETSGTATLAGDVVELVLDVRERERDDGNYERADELRDELEALGIEVQDTDEGATYRLPSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4D6</accession>
    <name>A0A3N6M4D6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90091">
        <property type="protein sequence ID" value="RQG90091"/>
        <property type="gene ID" value="EA462_08820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="152" mass="15503" checksum="A89238BD8EBBA95F" modified="2019-02-13" version="1">MSDVIPRSLRSNWPTLAASFACFAVAGIANGGAAGLAATIGTTGVAVVGVYLAARFVTTISRPELARLSFALWVAFLAVAGLYAIGPDAVIAAVPGPSEALSLSLTAITWGTLFSAASTTVFLGFRELGSASTSEIPEEQILDGESSDYSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M580</accession>
    <name>A0A3N6M580_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_13425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87859">
        <property type="protein sequence ID" value="RQG87859"/>
        <property type="gene ID" value="EA462_13425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="74"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="258" mass="29175" checksum="7F04B6341CB69CE7" modified="2019-02-13" version="1">MYLNMTQTNPRRPVKTVDTAMDIIQVLVESGGMTLSEIAEVVDLAESTTHRHLATLVYNELVFRDGKRYYLSFQFLNIGTQKQYRHPLFKAGREYVDDLAEKTGERVWISTMENGYSISLYWTSDKKPLFHHSRAGQRLHLHVSSVGKAILSELTDEKVDSILDQHGLPGLTDQTITEREMLYSELETIQEQGYATDSEETVNGMDSIAVAVSDDVADILGGIAIGCATNNMTRNREKEYKDLLRETAAEMAIRTRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5B4</accession>
    <name>A0A3N6M5B4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87909">
        <property type="protein sequence ID" value="RQG87909"/>
        <property type="gene ID" value="EA462_13685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="297" mass="32815" checksum="C9B819458A557732" modified="2019-02-13" version="1">MPRDRSTTLTDAVERIEPGSSIAMGLALEHAIPFAVGHELVRQQRDELTLVGPISDVLFDQLVGAGLVDRIRAAWIGNASAGSGYCFRRAVESSDLEVEDHSNLSLAMALHAGSLGVSYLPTRSLLGSDLLSSESPFETETCPFTGETQVLVPAIKPDWTVVHAQRADRYGDVHYWGSRGVTEEAIGAADHVLVTCEELVEPSVIKSDPDRVVGTREQVDAVVECPMGAHPSPLTGCYRRDHDRYVSYHDRTETPEGYREWADEWVHGVDREEYVDRLDPDLRDLEETVAAEVHYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5L5</accession>
    <name>A0A3N6M5L5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cation_ATPase_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88029">
        <property type="protein sequence ID" value="RQG88029"/>
        <property type="gene ID" value="EA462_14340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation_ATPase_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="9328" checksum="6DC7C17C4CCD6D43" modified="2019-02-13" version="1">MPLGDVSTALETSERGLDPEDARARLGRAGPNEIEAEEGVSPLRILFGVEPLGLVHWVQIAIAAAVFALLMALFVTVEDRYFERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7G9</accession>
    <name>A0A3N6M7G9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Like-Sm ribonucleoprotein core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91291">
        <property type="protein sequence ID" value="RQG91291"/>
        <property type="gene ID" value="EA462_04705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="75" mass="7918" checksum="6F422B5849D98053" modified="2019-02-13" version="1">MSGRPLDVLEASLGDRVTVRLKSDEEYVGDLAGYDQHMNLVLEEATISADGGGDGDAPVEDTTIIRGDNVVSITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7N5</accession>
    <name>A0A3N6M7N5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">30S ribosomal protein S4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps4e</name>
        <name evidence="11" type="ORF">EA462_05085</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91351">
        <property type="protein sequence ID" value="RQG91351"/>
        <property type="gene ID" value="EA462_05085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="KOW_RPS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_S4e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_S4e_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_S4e_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_S4e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_S4e_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="PTHR11581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RS4NT" evidence="10">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_S4e" evidence="9">
        <location>
            <begin position="91"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG91351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="250" mass="26940" checksum="4121720D8F5DA4AA" modified="2019-02-13" version="1">MTKHQKRLSVPKSWPVERKTEVFTVKAGAGPHGEEGVPLVVLLRDVLGYVDSKKEARYALSEDSILVNGESINDEQRPIGIFDILAFPGREESYRIFPDEGGRLALTEIDEESAGSRLGKIEGKQQVPGGDTQLSLHDGTNVIVDAESEYVANDSIVIDNEDKSIVAHFPYEEGALVTAIRGNHGGKIGEVETIDVTPGSGPNTVAVSTDDGEFETIEEYVVVIDENFTSDDSSSEDESGETASDGGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M806</accession>
    <name>A0A3N6M806_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-hairpin-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91491">
        <property type="protein sequence ID" value="RQG91491"/>
        <property type="gene ID" value="EA462_05885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="237" mass="24537" checksum="317C22E458AF4246" modified="2019-02-13" version="1">MGILQTLKSLLGLGDSSPQRRESREVGVTVERESSRGEVGHDEDDSDPAAAGSDAAGSTASLTEPSDDPDRAAEPAEAAGPTESDATPASEPDPADGVSHIEEAESPEPTDAESPESSDEHDGPERDEAKSDSVVDETGSDSETDETESDSESNELESDSESATEDDGSDSPRDADDEHGEPITSIKGIGPAYADRLADAGVETVTELADADAAELAGGTDISEKRIQGWIDRAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8A4</accession>
    <name>A0A3N6M8A4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoenolpyruvate carboxylase</fullName>
            <ecNumber evidence="2">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_06520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91601">
        <property type="protein sequence ID" value="RQG91601"/>
        <property type="gene ID" value="EA462_06520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="896" mass="102081" checksum="E5F72D6D8D7CCB63" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8M5</accession>
    <name>A0A3N6M8M5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91731">
        <property type="protein sequence ID" value="RQG91731"/>
        <property type="gene ID" value="EA462_06610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="144" mass="16327" checksum="5B3497BC524C9A99" modified="2019-02-13" version="1">MTRIQRTRTQDGRRLEVSHVFEAPPAEVWDLLVDTTRWTEWLPIVGVESTDRRIQAGTSGRIRVPGVWLPFVVTDRADRRWTWRIAGAMGATHRVDDLGAKRCRVAFELPPHAVGSAPLCLDAVERIERLWDAERSETAEAGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBA9</accession>
    <name>A0A3N6MBA9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S6e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps6e</name>
        <name evidence="6" type="ORF">EA462_00525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92751">
        <property type="protein sequence ID" value="RQG92751"/>
        <property type="gene ID" value="EA462_00525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00512">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_S6e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020924">
        <property type="entry name" value="Ribosomal_S6e_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="PTHR11502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="157" mass="16070" checksum="6F371C3C8F94E407" modified="2019-02-13" version="1">MASFTVVVGDPDTGSSYQLEAEEQDANRFIGRSIGEEVDGSAVGLDGYTLEITGGSDDAGRPLSGDVGGANLGEVLMEGRQTGYHPSRDGERRRVTVRGREVSDSVAQINAAISARGSTDVSELLGLDSDGDADADADADADADADADADADADADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCQ9</accession>
    <name>A0A3N6MCQ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91536">
        <property type="protein sequence ID" value="RQG91536"/>
        <property type="gene ID" value="EA462_06135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="252" mass="26760" checksum="DB19504BF2558C4D" modified="2019-02-13" version="1">MLHRARDGSILIQAVSGVRTRVRAVLDGRADDRSSRGGVRRLRTREAPFAGSRLVAGVSAVSRSGETLVRIGSASKLVGLGKAGKRAVESSFVYGWLTAEPEPDVIVIDLRETWTVGPAIRVVDRIEREASVAARTSLLVAGARRFASSVRERPIRVASLFVLAAAVGSLVATLSAASLSSDLVLAHLLAASLAVVGLRSRASLDELLETRIARALGAAFGPPEPPESARDRPANRSDRRNEPDSKSNSSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCZ0</accession>
    <name>A0A3N6MCZ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91636">
        <property type="protein sequence ID" value="RQG91636"/>
        <property type="gene ID" value="EA462_06725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="199" mass="21212" checksum="A55F2381BC85AFF5" modified="2019-02-13" version="1">MSDVIVVGGGPAGLSAALFTAKNGLETVVFDGDETWIHKAHLFNYPGIRSISGDEFLKLTRGQVGDRGADVRVGEPVTEIEVDTADDPDTEATDADRFRVETDDDVSTGEYLVLATGADRSIAENLECAFDDDGTVDVDLNMETSVENLYATGAMVRAEKWQAVIAAGDGAAAALDILSTERGDHFHDFDTPDDVPSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFQ1</accession>
    <name>A0A3N6MFQ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92736">
        <property type="protein sequence ID" value="RQG92736"/>
        <property type="gene ID" value="EA462_00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043813">
        <property type="entry name" value="DUF5795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19108">
        <property type="entry name" value="DUF5795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="75" mass="8258" checksum="3B051459522C1F83" modified="2019-02-13" version="1">MSENRVVQGRMVTAKSLAELIEGESVMEAEAITEADRDCPDCGGSVLEVGYMPSVTAFVTGRKCQDCDWREVERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFR0</accession>
    <name>A0A3N6MFR0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SRPBCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92746">
        <property type="protein sequence ID" value="RQG92746"/>
        <property type="gene ID" value="EA462_00500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="173" mass="19646" checksum="80A9D0932059C353" modified="2019-02-13" version="1">MDRILLSTVAHRSPEEVFPYVRSFTDYPRYADHLNAVSVHGDGNSGSVYDLHFEWWMLGYTANSKVIDVSPPDSLEWRLVNDVDARGEWRVESEPEAAPATAETASRIFFEAVYDPYSADTNAISLPRFVSIDWVVEKVQPRLLSEAETVVERLVADIEGTHRDVELTVHHMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGR4</accession>
    <name>A0A3N6MGR4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_02890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93166">
        <property type="protein sequence ID" value="RQG93166"/>
        <property type="gene ID" value="EA462_02890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="343"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="501" mass="54790" checksum="3DCE2A2794F78D36" modified="2019-02-13" version="1">MNIKQRLTHGFFYIFTGRVGAGVLTVLTTPLVVRVLGSGGYGDYAFAMAVYSALRTLAGGGVYEGARKYIAEYPDREDKAAVFSFYLTISFLSGATIALGLVLFTYGAIGTVLLEYRLRNYLYIVAVMVFFHAFYHLVRSSLMGFKLEEYSETMYVLNRVFFPIIGLPLAVIGFHVSGILIGHAASTFLIVSLGYVALKRQTNIRVRGMRSIVPNPAEIFHSRMFRYGLLNVVFVLLTKSLYITDILLLQPFVTSERVGFYNASLVVAEFLWFVPLALQIVLLHSASQLWTEGRTAEITAVASNITRYTLLLTGGVGIVLAIVGDSFLPIYFGGEFTASYVPMLLLLPGVVGFAVARPIYAIGQGHGNMRALIYGTGGAAILNVVLNLALIPQFGVYGAAVATSVGYGSMLIFHILAAKRLGFNPLRNVRLGRVVVTCTGPIPILWLIDRSLESNVLSIVVVTLVGLASFFLLAWATRALSRSEVVEVLETVPRVRQLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGU4</accession>
    <name>A0A3N6MGU4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93206">
        <property type="protein sequence ID" value="RQG93206"/>
        <property type="gene ID" value="EA462_03145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="474" mass="52895" checksum="2FC994AFE728D9AF" modified="2019-02-13" version="1">MAETHTVQSDDGTSTSKTNRSNAERPPRLRGFPLIGRTLSIARDPLEFLESAREYDDVVVYEAYGTEFALVSDPALVETILVSRADEFRKGEFETGFGELIAPSGIAFTEGERWRRQRNLLQSSFTPDRVRSAADGMVTEASALVDGWDDGETIVLRDALSAYTLRVLSRTLFDLPLEDDRTAIVRRATTALDEYASPRRLALESIVPSWLPTPAERKYENAMGDLEALVADLVETRRTKDAAGDDLLSLLARAEYPDGTRLTPTEIRDQLVTFLFAGHETTATTLTFACWLLADDSAVRSELERELEAVCGDRDPTIADLEDLEYTEAVVNEAMRLYPPITSIYREPCAETVLGNHLIPAGTTLQLPVYGIHRDDRWWSAPEAFRPERWLNGSNGGLTRDDRERPEYAYYPFGGGPRHCLGMRFAMVELQLALATLVSKIVLEQVTESLEPSLGVTLDPGSVEARVRKRENSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MR88</accession>
    <name>A0A3N6MR88_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable chemoreceptor glutamine deamidase CheD</fullName>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheD</name>
        <name evidence="5" type="ORF">EA462_16650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86763">
        <property type="protein sequence ID" value="RQG86763"/>
        <property type="gene ID" value="EA462_16650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16352">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01440">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038592">
        <property type="entry name" value="CheD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005659">
        <property type="entry name" value="Chemorcpt_Glu_NH3ase_CheD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147">
        <property type="entry name" value="PTHR35147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03975">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="210" mass="22191" checksum="BC07F6E095776AC3" modified="2019-02-13" version="1">MTGSEDRRDGSDRSTSFDPSDLPIHDDTDSDSRSTTSEQKTGLSSSARRVSTNAIPVTIADYAVTDADVPLKTSGLGSCIGVAIHDEEAFVSGLLHFMLPKASQAHSGPHPEAKFADTGIEAMLSEFRDLGGDPTRSWAKGAGGATMIVFEKTKPSIGERNADALRRELETHDVSIVGTDFGGNHGRSLEFVPGRGTLTITGADGTERTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRN7</accession>
    <name>A0A3N6MRN7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86933">
        <property type="protein sequence ID" value="RQG86933"/>
        <property type="gene ID" value="EA462_14845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="211" mass="23695" checksum="3F03A6434465E31E" modified="2019-02-13" version="1">MSQSELTREVARRVFASEFNDSTYAFKESDDERAPNYALLPTGDRANRVLVVGTLTETEDVGEDSEYWRGRVVDPTGTFFVYAGQYQPEAASVLRDTEPPAYAAVVGKPRTYETEDGTVNVSLRPESISIVDDATRDRWVVETAERTLDRIEAFEEWEAEQEAPESASTAPTNEYAQMARERYDSPVVNYRNDVIQALEGLEETSDPEATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRQ5</accession>
    <name>A0A3N6MRQ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-phenylpropionate/cinnamic acid dioxygenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86953">
        <property type="protein sequence ID" value="RQG86953"/>
        <property type="gene ID" value="EA462_14950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00667">
        <property type="entry name" value="ring_hydroxylating_dioxygenases_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000391">
        <property type="entry name" value="Rng_hydr_dOase-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41534">
        <property type="entry name" value="PTHR41534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00866">
        <property type="entry name" value="Ring_hydroxyl_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="168" mass="19639" checksum="1851FACE2373C441" modified="2019-02-13" version="1">MNDDLVLTLECRQFLVNEAELLDDQRLHEWLDLLTDDVEYRVPRRVMRERGAEAAEFSDEGFLFRDDKGTLRTRVERYDKEYAWAENPPSRTRRIVGNVRVVEQTADDVTVKSNSIVYRSQGDESDHDLIAGERVDVLRRADEGFRLARRTVHLDQTVLATRNLSIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSX0</accession>
    <name>A0A3N6MSX0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87865">
        <property type="protein sequence ID" value="RQG87865"/>
        <property type="gene ID" value="EA462_13460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="64"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="381" mass="40817" checksum="0AA62CD8503AFD16" modified="2019-02-13" version="1">MGNIAGMVMGLCRAYTFLIRTETRVTTCRQQTNPVGACTPKELGLHDSSVYPIPMRAITYHETGGPDVLQVEEKTKPEPASDEVLVRVEATSVNQIDTLFRSGVDMFVPDQFPAVAGVDMAGVVEEIGSEVEGFTIGDRVLGAEFPGPTGANAEYVASSPAFLAPLPEEVSFEAGAGIGHVGITSWRSLVDHAALEPKETCLIHGGGGGLGPIAVQLADRIGGRVVTTSSSPDRRDELERLGAEVALDYRRDDLQEAFLEAAPGKANVIIDGHLNNYFEFDLEVLARFGRIVCIEFTGDEGGEASFSQFHTRLGNWKEARLHWVGAPNAPDVSDVLGRLAALVASGDVEVPIAKTYSFDEAADAHQAMIDSDYFGKLILEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUF3</accession>
    <name>A0A3N6MUF3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor 1A</fullName>
            <shortName evidence="3">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eif1a</name>
        <name evidence="6" type="ORF">EA462_11550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89012">
        <property type="protein sequence ID" value="RQG89012"/>
        <property type="gene ID" value="EA462_11550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="PTHR21668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="5">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="94" mass="11152" checksum="063ABE98A9EAF7E2" modified="2019-02-13" version="1">MTEESGRRNLRMPNSDEVFAVVTEHLGGNHVRLRCQDGEERLGRIPGRMKYRTWIEQDDIVVAEPWDWQDEKATIEWRYTGQDADQLRREGHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUM5</accession>
    <name>A0A3N6MUM5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89102">
        <property type="protein sequence ID" value="RQG89102"/>
        <property type="gene ID" value="EA462_12070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="360"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="568" mass="61722" checksum="D40B0D9AB0A9F7D1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUV6</accession>
    <name>A0A3N6MUV6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class III-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89192">
        <property type="protein sequence ID" value="RQG89192"/>
        <property type="gene ID" value="EA462_12560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="456" mass="49162" checksum="069EA45EBD1382C8" modified="2019-02-13" version="1">MDRDTAEPDVGTFPGPNGREWVEFHGANAAPSEYSHEFVWDITREADGPFVTDVDGNVLLDFTCHIGAAPLGYNNEKILGKLREFDLVEPMKIAGQDMYFGAGPTPEESSVPGSSHLMEKLVSVSSQYGMDTVFLSNSGAEAVENAMKITNDHRAPAKYGVAFSGSFHGRTLGTLSVTKSKEVYTRRYPEISGIETVPFCADRTCDPGSCDCGFFASGGSQLRNALSPEGGYVDPDEIAFVVLEPIQGVGGYRFPSEAFMREVGDVADEYDIPLVVDEIQAGVGRTGEIWASDHYPIEPDVIASAKALRVGATISRSEVFPTEKNRLGSTFGGGDLLGSMIGAFTLEAIQEYDLLENATSRGTQAKELLRDDAPEYVEDVRGKGLMLAVTFDTAERRDAVVAESIDRGLLTLGCGAKTIRLLPPLDSSEREIELGVGIFLEAIEAAITTATQRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MZS8</accession>
    <name>A0A3N6MZS8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidylprolyl isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91112">
        <property type="protein sequence ID" value="RQG91112"/>
        <property type="gene ID" value="EA462_03700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="172" mass="18848" checksum="1F7D87BFD03FA17B" modified="2019-02-13" version="1">MGNVTATLHTSEGDIDVELYDERAPRTVDNFVGLATGGQSWTDPETGDEIEGEPLYDDILFHRIIDGFMIQGGDPTGTGRGGPGYQFDDEFHEELRHDDAGVLSMANSGPDTNGSQFFITLDAQPHLDDRHAVFGKVVDGMDVVREIGDVDTDENDRPTEDVLLESVSIDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MZX1</accession>
    <name>A0A3N6MZX1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_03975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91162">
        <property type="protein sequence ID" value="RQG91162"/>
        <property type="gene ID" value="EA462_03975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="365" mass="38760" checksum="C3A05D05EF58CBB5" modified="2019-02-13" version="1">MNVRTTFFVVLLLALGAIAALMIVPLLQYVMAAAFLAFVLHPVHARLERRVGSRISALLLTAVAVVGIVVPFLLVSLIVLQTAASFLRDVDGASLIERVRTIARDDLGLDEEYVHSIESALLAEIDSSLSNAIEVALFELVGLVNTSIEMGLGLIVFVFLLYYLLADGRTFIAWLTDVIPLEEEVRSELFSEIDVVTWAVIKSHVLVAVVEGVLGGFGLYLLGVPNVAFWTVVMIVVAFLPAAGVWLVWGPAVGYLALVSGPVPAVALLLYGVTVLSLIDNYLRAYFVDRGSGLHPAVVIIGVIGGIYLLGIMGLFLGPVLLAVFKAGITVFSRTTTVTGDGDRSAASTVGSLPESEPESPTTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N082</accession>
    <name>A0A3N6N082_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PspA/IM30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91282">
        <property type="protein sequence ID" value="RQG91282"/>
        <property type="gene ID" value="EA462_04655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="33"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="280" mass="32083" checksum="3FD923BE8AC4094C" modified="2019-02-13" version="1">MGILSRTSYVIRSKLNSVLNRAEDPTQTLDYSYEQMRDQLQEVKRGIADLTTQKKRLEMQKRRLEENVDKHNEQARTAVQQDREDLARRALEKKKTKMNQIEDLERQVSELQSQQDRLIEQKDELQTRIEEFRTKKETMKARYEAAEASSTVSEAMTATGDEFEDVGRAIERAEEQTEDMEARAAALDELHETGAFDDVMSDKDSIDRELEELSTGSGVEAELETLKSEVDGTEETESESQSETDVETDIDESELEDLEAGVDDEEVEAELAELQEEENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0L3</accession>
    <name>A0A3N6N0L3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91442">
        <property type="protein sequence ID" value="RQG91442"/>
        <property type="gene ID" value="EA462_05600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="891" mass="98127" checksum="32140ACE52ED1F59" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N182</accession>
    <name>A0A3N6N182_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91712">
        <property type="protein sequence ID" value="RQG91712"/>
        <property type="gene ID" value="EA462_05310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="242"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="620" mass="67967" checksum="3336DDBFA4674473" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3P6</accession>
    <name>A0A3N6N3P6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92762">
        <property type="protein sequence ID" value="RQG92762"/>
        <property type="gene ID" value="EA462_00580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="99" mass="10512" checksum="9A2D218DEB3C9D8B" modified="2019-02-13" version="1">MWPPDSPLLALAGLAITVAVFAVVYWDATRIEMGRPLLWASITASTCAVGVGLYVFVPTAPLTGVLLTANTGPVLYGFEREVTTETDEPAEPGTLPHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N417</accession>
    <name>A0A3N6N417_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92912">
        <property type="protein sequence ID" value="RQG92912"/>
        <property type="gene ID" value="EA462_01435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="157"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="264" mass="29397" checksum="7315B6F82DE06435" modified="2019-02-13" version="1">MDESVVVSPDWLATHLEEPRIRVVDVRDPWEYDGIGHVPGAVSIPFESYRDESDVDRGTLPGPDAFASLLSEVGVTPDDTIVAYDDTHGVFAARFVLTALEYGHDDVRLLDGDYSAWNRAHETTTDAPDPGSAEYGADPLAREESPLVGLEAVEDALERDAVFVDTRERGEFEEARLPGAVRFDWREVVDDETRRLKPEAELEELLSDHGITRGREIVLYCNTARRISHTYVVLRALGYEDVAFYEGSLTEWLANDGEVETGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4T3</accession>
    <name>A0A3N6N4T3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">radA</name>
        <name evidence="9" type="ORF">EA462_03125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93202">
        <property type="protein sequence ID" value="RQG93202"/>
        <property type="gene ID" value="EA462_03125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00348">
        <property type="entry name" value="RadA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="78"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="8">
        <location>
            <begin position="283"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG93202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="343" mass="37196" checksum="A535E3B558C7B823" modified="2019-02-13" version="1">MPEVNLEELPGVGPATADKLQEAGFDSFQSLAVASPSELSNTADVGESTSADIVRAARDAADIGGFETGSTVLERRNEIGKLTWHIDEVDDLLGGGIETQSITEVYGEFGSGKSQVTHQMAVNVQLPQEVGGLHGSAIFVDSEDTFRPERIDDMVRGLPDEAIDATLDDREIEGSATDEEAVDELIDDILDKIHVAKAFNSNHQMLLAEKAKELASEHEDSEYPVRLLAIDSLTAHFRAEYVGRGQLADRQQKLNKHLHDLDKVGNLYNAAVVVTNQVASNPDSFFGDPTQPIGGNILGHKSTFRIYLRKSKGDKRIVRLVDAPNLADGEAVMRVQGDGLKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUS9</accession>
    <name>A0A3N6NUS9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86960">
        <property type="protein sequence ID" value="RQG86960"/>
        <property type="gene ID" value="EA462_14985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="95" mass="10768" checksum="3CB30BAADEA39E59" modified="2019-02-13" version="1">MEAPLATPFVRPVLTATGVGPTITIVDRNLVFRSIQLWNFPGTNTRDSLEATGRCVLWTRIRHCLLPVGNRVASIHHVLRGHRTRSLIRSRKPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWR9</accession>
    <name>A0A3N6NWR9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_11530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89009">
        <property type="protein sequence ID" value="RQG89009"/>
        <property type="gene ID" value="EA462_11530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="458" mass="49776" checksum="E8E1E7206FBAAE5C" modified="2019-02-13" version="1">MDNGVLEDWNPEDESFWNEQGKRIAWRNLTVSVFTLFLSFAIWVLWSLIVVYLPEAGFTYSESQLFLLIAIPSLVGATGRLAYSFVVPIFGGRRWNAFATATLLIPAIGIGFAVQNPNTPFWIMAVLAATAGFGGANFSSSMDHIAYFFPKRDEGTALGINAGIGNVGVSAAQFLVPVVIFLGAFDGFGGATQTYVTGNPGEQSMWLQNAGFVWVPFILVGTVASYLWMNDIANVEANFGEQLTILTEKHNWIMCWLYTGTFGSFLGYATAFPLLTSIQFPGRNVALFAFAGPLVGALVRPPGGWLADRLGGARVTLWVFVTMAIGTGLVIYFMIEGIFWGFFAAFILLFLASGIGNGSTFKMVPVIFRKQHLREVNEDDSEAQKKAHSRAELEAGSVLGFSGGIGAYGGFFIPQGFSTSVELTQATTAAMGAFLAFYLSCILITWYYYERAGAEVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX64</accession>
    <name>A0A3N6NX64_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89219">
        <property type="protein sequence ID" value="RQG89219"/>
        <property type="gene ID" value="EA462_12705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="103"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="222"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="406" mass="46154" checksum="EA691B9E1C0ED2C8" modified="2019-02-13" version="1">MSNTVTDVPERNSTTAEQYASGKKLLVITHNYSNFTKGQIDAIADTFEEILVLVRYNRVTDLSGILEWDTLKKYGRDFKIADSAPENVEIVPLALTYAPIEQWYKRLGKHHYWATKAKLRGRIESFDIIHAHFSWTAGYVATRLGEEFGLSTVLTVHENEDRLREELQSGNEELYWTWRNVDAIIRVNEKDCETLSEFNESVYAIPNGYDRDRLPLKKAANAREEIGISEGAKIVFSLGGLIPRKRFKLLIRAISAVEHDEPIVCAIGGRGKERKKLERLARRYSDGSVEIRVLGFISDEELANWLNACDIFALASESEGNPTVMFEALGCGKPYVGTNVGGVSEIITSDEYGLLCQPNDENALVEVLQKGLSKTWQRETILEYGTRYTWNEIAEEVYDVYRYVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX86</accession>
    <name>A0A3N6NX86_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89279">
        <property type="protein sequence ID" value="RQG89279"/>
        <property type="gene ID" value="EA462_11570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="88" mass="9874" checksum="2CEE6633F62F4EFE" modified="2019-02-13" version="1">MGTGLDRAHTELERAAETASDDVREDVQVVLSAFEEYEIEDRLPDHAVFDGHLNTLRQASERASGETRERIDDGLEAAEAFREELEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NY91</accession>
    <name>A0A3N6NY91_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_07050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89769">
        <property type="protein sequence ID" value="RQG89769"/>
        <property type="gene ID" value="EA462_07050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="395" mass="43407" checksum="2B09649B0D733A68" modified="2019-02-13" version="1">MARVRLENVTKRYEDVTAVDDVSLDIDDGEFVTFVGPSGCGKSTTMETVAGLTRPSGGRVYIGDDDVTDLAPKDRGVAMVFQNIALFPHMDVFENISFGLRLRKYDDDEIRRRVEGAAEIVQLEGMLDRMPDELSGGQRQRVAIARAIVRNPDVFLMDEPLANLDAKLRVHMRTELQRLHRELGTTVIYVTHDQAEAMTMSDRIAVLNEGKLQQIAPPLTCYNEPANRFVAGFIGSPSMNVAEGELVEGGLETEHFRIEVDRAVVSDASIGDALTFGVRPEDVHLEAESSSIEYPTDPITARTDVLEPMGDEVFVYLVLDEGSSRSMAQDPATAADQLLMSVTPDTEIRAEQSVEVVLDRSKCHLFETETGDALTHGVVRRSGSDSGTAETQADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYA5</accession>
    <name>A0A3N6NYA5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0104 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_07155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89789">
        <property type="protein sequence ID" value="RQG89789"/>
        <property type="gene ID" value="EA462_07155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="342" mass="36677" checksum="D54555FAAA28BEFC" modified="2019-02-13" version="1">MKGRITIAFGISVVLLGFLILAVGWESVLASIGQATLRIYAVAFLAISGCLLFRALVWHRVLSVVDRPRPYWLVSGIVLTATFAKYVAPYGLVTSGVGVAAVVSRYYDSAYEEGLAATVSADFLNYLPYYSFGAVGASYVLFVYSPSIPLRQYTTVGVLVGSGVIALVLVAWRSQRILIDCLLRILDSARRVVARVSSTKSRHLRRENLSARFEGFSTTVELVSRNRSSMAIALVYAHLAWLGLAIALYATAQAVAMPIPFGVAILGVALSKLGFLVPTPGGVGGVEFTLASVLYLLTPMGMAIATSIAILFRFASYWFPMCLGGVISMALTLSDPLPPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYI9</accession>
    <name>A0A3N6NYI9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89909">
        <property type="protein sequence ID" value="RQG89909"/>
        <property type="gene ID" value="EA462_07815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="136" mass="15160" checksum="78F0DF9972C30985" modified="2019-02-13" version="1">MNGGSDMTLAFELEALTELASPESVFEDARGWSEYIGVVSEKPTYVVTNFTRKNRIRQDFFSGPRGKAESLEGVKDQFDTERYVFIGAGEDDSDLAEDVGWEYLGIEDAAESADWVLATSVDSEDEDSDPVRDDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZR2</accession>
    <name>A0A3N6NZR2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pribosyltran domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87066">
        <property type="protein sequence ID" value="RQG87066"/>
        <property type="gene ID" value="EA462_15650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="107"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="236" mass="25348" checksum="CCD5727219FB0E06" modified="2019-02-13" version="1">MNRAEKAALQLRAVDVLRMLKETRTYDELAVTTGLPAGDLNRYVNGHVLPGTDRAHDVVEDLGRTALAEELGARIQVDDEGYVDNTGTVFDQPFLDLVSPVIANGFEFGRPDVVLTAATDGITLAASLASYYGTRCAYAKKRKETAVEEFIEARERLESGIQLTYYLPASAIDAGESVLVVDDLIRSGETQELLLDIVETADADVAGVFTLIAAGEDGIERARGRTDAPVGALTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0H1</accession>
    <name>A0A3N6P0H1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87978">
        <property type="protein sequence ID" value="RQG87978"/>
        <property type="gene ID" value="EA462_14060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="340" mass="34656" checksum="F86379E117E52BD6" modified="2019-02-13" version="1">MELLGLGVEFLVLFVSFGFMVGVFFGFFGMGGSFLVTPALLILGYPAPVAIGSSMAFVFGTAVIATMKHHDVGQVDYKLGALMFVGIALGIEAGKYVVFFLEALGRAELVVGVAYVLLLAAIGLVFVRSALTQDEGSTGTDHADDEIPAIATKIKSYDVPPMVTLTDGSEASMWTISGVGGGVGLVSGFLGVGGGFIRMPAIYYLVGVPLAAAVGTSLFGALMSGAVGAFTYGLGGVIDLGIVTALLAGSALGARIGSAATAYIDENDVTIYFGVMLLLASTAVALGELATWLEIPTLDTISFVLLVGSSAFVTTMIFYYGAQAVRANGTSPAATVGGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P274</accession>
    <name>A0A3N6P274_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase Pus10</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine 54/55 synthase</fullName>
            <shortName evidence="4">Psi54/55 synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pus10</name>
        <name evidence="6" type="ORF">EA462_06905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(54) in tRNA = pseudouridine(54) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:57876"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14141"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91669">
        <property type="protein sequence ID" value="RQG91669"/>
        <property type="gene ID" value="EA462_06905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01893">
        <property type="entry name" value="Pus10_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005912">
        <property type="entry name" value="Pus10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="PTHR21568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01213">
        <property type="entry name" value="pseudo_Pus10arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="THUMP" evidence="5">
        <location>
            <begin position="62"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="449" mass="49533" checksum="A9E8BA5D5B626653" modified="2019-02-13" version="1">MITEDVRALLATGAVCDSCLGRPFAERSFGLTNAERGRALRTTVALADDDDFEPDTPGDCWVCEGYCGTFDAIADAVVDALEGVAFATYQVGSQVPPLVEENERLLRDDADLKPDVGESIKREVNREVGRRIGARTGTEVDFDRPDVLAVVDLEGFDPFETLESNRVTSHAVDVQVNPAFVYGRYRKLERDIPQTEWPCRECGGSGVQLGDDGEEPCDYCGGSGYMYETSVEQVVRPHVVEAMDGDEGTFHGAGREDVDARMLEGGRPFVLEVKRPRIRDPDPADLEREINAAAEGAVEVDGLRLATYEMVERVKEHDASKQYRADVVFENPVDRDAFEAVLEELSGTTVEQYTPQRVDHRRANLTRERIVYEIGGELLEPTRAEVRIHGAGGLYVKELISSDDGRTDPSLAGLLETGAEVTALDVTGVDGEDEPFELEEYFRDEPRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3Q9</accession>
    <name>A0A3N6P3Q9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydropteroate synthase</fullName>
            <ecNumber evidence="5">2.5.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folP</name>
        <name evidence="5" type="ORF">EA462_08130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89965">
        <property type="protein sequence ID" value="RQG89965"/>
        <property type="gene ID" value="EA462_08130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="4">
        <location>
            <begin position="553"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="818" mass="88261" checksum="2281C90651A2A051" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P406</accession>
    <name>A0A3N6P406_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90115">
        <property type="protein sequence ID" value="RQG90115"/>
        <property type="gene ID" value="EA462_08965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="198" mass="22439" checksum="67A1BC09986FE12C" modified="2019-02-13" version="1">MERTPNGTAVGVDDPYEFAGICDYLTNDGRCRYAFDHYEADPEFARDRAREDYACPVVDSGSEADSGAPDRESDALPGWSDCPHFRSRNHDRECVRCGLEEKRIAHDDERPLLEEHHLSYADGLRSSGESDASDSVNLSHEITIYLCRWCHAKVHTSWARITDDVAPDPDAIAALEDRRGREYDELGFESAAERRDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4R2</accession>
    <name>A0A3N6P4R2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="3">2.5.1.114</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA wyosine derivatives biosynthesis protein Taw2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">taw2</name>
        <name evidence="6" type="ORF">EA462_01830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.114" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92979">
        <property type="protein sequence ID" value="RQG92979"/>
        <property type="gene ID" value="EA462_01830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01922">
        <property type="entry name" value="TYW2_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030867">
        <property type="entry name" value="TYW2_archaea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="5">
        <location>
            <begin position="112"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="384" mass="41469" checksum="61773FE35807AEE3" modified="2019-02-13" version="1">MSDDDFPSESPSVRDVVGRTDGETALAAVVEKPRTETAIESLRAEGVYDDSRRVRETESGTIALPVTEPPSETPVLEVVRQLDPEVRLTDVEDVLGARGWSTDDLATVPSSWAVIGSVVMVSVPADCPDELELADALLEVHGEADSVLADEGIANDGVAGTHREPRTRLLAGDPDTETVHTEHGTRYGLDPAAVMFSPGNQAERARMGDVCEPGERVFDMFAGIGYFTLPLVRAGADVTATEINPTAFRYLVENAMLNDVSERVDAYMSDCREIAADVEADRVVMGYYGRSTEAAPPEDECGRGGGTRSDEAAEFLPAALEALVPGGLVHYHEATPEPRLWDRPLERLESAADTAERELTVLDRRRVKSHSAGVAHVVVDARFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P550</accession>
    <name>A0A3N6P550_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Threonine synthase</fullName>
            <ecNumber evidence="5 9">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EA462_03035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5 9"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93189">
        <property type="protein sequence ID" value="RQG93189"/>
        <property type="gene ID" value="EA462_03035"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="80"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="10">
        <location>
            <begin position="247"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG93189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="425" mass="44496" checksum="35FDB29D670C38EC" modified="2019-02-13" version="1">MSLNLSADQPAVPDDADDGVWLECIECGETFAPFADVRYTCDECDGLLEVRYADLPTFGDFEGQGVWRYTAALPLEEGVTTQEGATPLYEVPRLEDEIGVEALRIKHEGMNPTGSFKDRGMTVGVAVAKELGVDRLACASTGNTSAALAAYGSRGGMETLVLLPAGKVAAGKVAQASLHGARILEVDGNFDACLDIVQELAAKGEAYLLNSLNPFRLEGQKTIGLEILEGFLSDYDAVPDRIVLPVGNAGNTSALYKAFRELVQAGALDESEVPKLVGVQAEGAAPMVEAIENDADEVRRWDDVETRATAIRIGNPVNAPKALPGIRETGGTAISVTDEEITDAQRDLAGEGIGVEPASAASVAGLRKLRAEGVVSDDERVACLTTGHLLKDPDAAAAAGSDPEPVPAETNGVLATLASENSSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9W0</accession>
    <name>A0A3N6P9W0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_02450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93085">
        <property type="protein sequence ID" value="RQG93085"/>
        <property type="gene ID" value="EA462_02450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="4">
        <location>
            <begin position="145"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="500" mass="57267" checksum="56D77AF4A6D38B0C" modified="2019-02-13" version="1">MTLSPDKLESHLFECADIIRDAVDPTDYKEYILPLVYYKSISDEFEKQYAENVDEYGEDFARRQNLYDIPVVPEGYLWDDLRSVSDNVDQALNEAFEALTEENPSLKGLFRADYIDADALDDDRLGKLVEHLNKYDLDRDSIPPDMLGEAYMDLVRHFAEEEGKSGGQFFTPPHIVNLCVRLVDEFEDGHTFHDPTVGSGGMLTEAARYYLEEQDGDPAKLTFTGQEINPDIAAIARMNLSIHGLNGTIEREDSLSNPAFTNEDDNELTRFDRVLANFPFSANWDKDGLQDDPYDRFDWHEKLPRADRGDFAFIMHMAKQLKTPEKDGNGGKAAIVIPHGVLFRKHESRYRKPMLEADMVEAIVGLPENLFQNNSIPSAVLVLNTDKPAEREGEVQFIHAADEAFYEELSNQNELTEGGLDHIVENFRNWTTEERVSRTVSIEEIKENDYNLNIALYVDTTEPEEEINVKEELAKLRELQDERDAIESQMSQHMEALNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHP9</accession>
    <name>A0A3N6LHP9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">trpB</name>
        <name evidence="14" type="ORF">EA462_16325</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86704">
        <property type="protein sequence ID" value="RQG86704"/>
        <property type="gene ID" value="EA462_16325"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="54"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RQG86704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="390" mass="42665" checksum="FE4D72CA457D9B7C" modified="2019-02-13" version="1">MVRDGSPQTFGQFGGRYAPDELEEVLEDLATEYDHLKDDEEFREELDELLRNFAGRPTPLYHASSLSEEYGATIYFKREDLVHGGAHKLNNALGQALLAKHAGKERLIAETGAGQHGTATSFVGAHTGLETEIYQGKKDAERQRMNVFRMEQMGATVNKVTRGGSGLADAVDAAMEDLIKNNENTHYLVGSVVGPDPWPRMVRDFQSVIGEEAREQILEQEGKLPDAAVACVGGGSNAIGLFHPFFDDSEVDFYGAEAAGKGLDTNQHAAPLSEGKEEVYQGMRTRVIDDDVEVHSIAAGLDYPGVGPEHANYQELDRCSYRGIVDEDALQAFQDLCKYEGIVPALESSHAVALAKELAAEMDEDDVLLVNLSGRGDKDVEKIAEEYLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI67</accession>
    <name>A0A3N6LI67_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0284 protein EA462_15220</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0284 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86994">
        <property type="protein sequence ID" value="RQG86994"/>
        <property type="gene ID" value="EA462_15220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01086">
        <property type="entry name" value="UPF0284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002805">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38811">
        <property type="entry name" value="PTHR38811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00303">
        <property type="entry name" value="TIGR00303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="345" mass="34544" checksum="DA2AC1E2E563CA1F" modified="2019-02-13" version="1">MRVVLPAGTTETALIDGISAAGAAPDLMAHTPSADVEILAYGEPTAAPVTPVSPTGCPTPAAVTRAVREVIGFDLSVVDAGLARSTTAPTVDLGATPGDDIRASVAVPDASTIFDRAYGFGSSLPDDEILLGETVPGGTTTALGVLTALGEPMSVSSSLPENPIERKRRVVEEGLDASDLEAGSCDGNPMAAIRAVGDPVQAVVAGIAAGALESGTDVTLGGGTQMVAVAALLRHAGVDGPLSIATTSFVAAGQGTELLTTCERFDCELVVTDPGFDGRDHVAMSRYCAGEAKEGVAMGGVLSLVDDGGMAAVRAQFAAVCDRLGIDSNADESIDSSESSDDRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIC6</accession>
    <name>A0A3N6LIC6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_15815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87094">
        <property type="protein sequence ID" value="RQG87094"/>
        <property type="gene ID" value="EA462_15815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="33"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="382" mass="40636" checksum="4EDB199412331E80" modified="2019-02-13" version="1">MTMEFTDRVTRVEPSATLAISALATELEADGADVVDLSVGEPDFPTPRNIVDAGQEAMDAGHTGYTTSAGILALREAISEKLADDGLDRGTDEIIVTPGAKQALYEIVSSLVQDGDEVVLLDPAWVSYEAMVKMAGGSLSRVDLSPHDFQLEPARDELEEAVSADTELLIVNSPSNPTGAVYSDAALEGVRDLAVEHDVTVISDEIYKEITYGVEPTSLGTLDGMADRTVTVNGFSKAYSMTGWRLGYFAGPSELIDQAGKLHSHSVSSAVNFVQHAGIEALENTDEAVAEMVEAFEGRRDLVVDLLADHGVDVAVPDGAFYMMLPVGDDDQAWCEGAIEDAHVATVPGSAFGTPGYARISYAASEERLEEGIERLVAEGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIH6</accession>
    <name>A0A3N6LIH6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Translation initiation factor 2 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">aIF2-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 9">eIF-2-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">eif2b</name>
        <name evidence="13" type="ORF">EA462_15250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86999">
        <property type="protein sequence ID" value="RQG86999"/>
        <property type="gene ID" value="EA462_15250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00232">
        <property type="entry name" value="eIF_2_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004458">
        <property type="entry name" value="TIF2_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="146"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG86999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="203" mass="22448" checksum="3CE011C5CD2B3A12" modified="2019-02-13" version="1">MDYESSLERAMDDVPDIGGDEQRLQIPDARAQKDGAFTRFTNLGEIADVLSREDEHLHRFVQREMGTSGKLEDGRGRYNGTFSTTDFDAAIDAYVDEYVLCSECGLPDTRLVREDRTPMLRCDACGAFRPVTKRSTTSQQHQQADAVEEGKTYTVEITGTGRKGDGVAEKGSYTIFVPGSEEGDVVEIYIKNISGNLAFARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIY7</accession>
    <name>A0A3N6LIY7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TrmB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87976">
        <property type="protein sequence ID" value="RQG87976"/>
        <property type="gene ID" value="EA462_14050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005104">
        <property type="entry name" value="WHTH_HrcA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03444">
        <property type="entry name" value="HrcA_DNA-bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HrcA_DNA-bdg" evidence="1">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="172" mass="18311" checksum="D59F6544626EA714" modified="2019-02-13" version="1">MPQFELSSSQRTMLSSLVNTAQSEGAPVPAKAIASAIDREPGTVRNQMSTLIDLGLVEGIPGPNGGYRPTETAAEALGRESVDDPTMAIMTREFDRVSALVDDIAFTNVHHPTTCRARIQFQESIRGLEEGDAIAIGATPNAELLLAGVIEAIEPGRNRILLDISQLEASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ43</accession>
    <name>A0A3N6LJ43_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanine dehydrogenase</fullName>
            <shortName evidence="1">AlaDH</shortName>
            <ecNumber evidence="1">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ala</name>
        <name evidence="2" type="ORF">EA462_14605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88076">
        <property type="protein sequence ID" value="RQG88076"/>
        <property type="gene ID" value="EA462_14605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006522">
        <property type="term" value="P:alanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00935">
        <property type="entry name" value="AlaDH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028609">
        <property type="entry name" value="AlaDH_arch-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="328" mass="34978" checksum="8DAEF47B7581AB80" modified="2019-02-13" version="1">MQTVLLDQSAVNANAETSAVISAVEDAFAAYERGTVQMPVKSYVDLERYNGDFRSMPAYIDAGEWDAAGIKWVNVHPDNPSEHGLPTVMGTMVYSDPETGYPLAIMDGTELTMKRTGAAAAVATDYLAIEDATSLGIVGAGVQSYTQLDAIAAVRPIEDVVVADTNSERVQAFIDAFEDRFSVVEGTIADAAACDVLSTVTPVDSPIVEHSVVGSHTHINAMGADAAGKQELTEDLLLESTVVIDDYGQTTHSGEINVPWREGTFSDEHIYGELGEIVAGKKSGRTDDDGITVFDSTGLAIQDIAAAHVVYEHAIDRENGSRFELINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJT4</accession>
    <name>A0A3N6LJT4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oxidized purine nucleoside triphosphate hydrolase</fullName>
            <ecNumber evidence="11">3.6.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">2-hydroxy-dATP diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">7,8-dihydro-8-oxoguanine triphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">8-oxo-dGTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Methylated purine nucleoside triphosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside diphosphate-linked moiety X motif 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EA462_10410</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71395"/>
            <dbReference type="ChEBI" id="CHEBI:172878"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63212"/>
            <dbReference type="ChEBI" id="CHEBI:77897"/>
            <dbReference type="EC" id="3.6.1.56"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:31584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71361"/>
            <dbReference type="ChEBI" id="CHEBI:172871"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:65397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63224"/>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:31576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + N(6)-methyl-ATP = diphosphate + H(+) + N(6)-methyl-AMP</text>
            <dbReference type="Rhea" id="RHEA:67608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
            <dbReference type="ChEBI" id="CHEBI:172873"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:67609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H2O + N(6)-methyl-dATP = diphosphate + H(+) + N(6)-methyl-dAMP</text>
            <dbReference type="Rhea" id="RHEA:67604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169976"/>
            <dbReference type="ChEBI" id="CHEBI:172872"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O + O(6)-methyl-dGTP = diphosphate + H(+) + O(6)-methyl-dGMP</text>
            <dbReference type="Rhea" id="RHEA:67600"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169974"/>
            <dbReference type="ChEBI" id="CHEBI:169975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67601"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.56" evidence="11"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88808">
        <property type="protein sequence ID" value="RQG88808"/>
        <property type="gene ID" value="EA462_10410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003563">
        <property type="entry name" value="8ODP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01403">
        <property type="entry name" value="8OXTPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="18">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RQG88808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="169" mass="19281" checksum="9C9FD30111AD0162" modified="2019-02-13" version="1">MIEATLCFPLRGDVEGDAKEVLLIEKRRGLGQGWYNGPGGKLEADETPRECAVRETREEVDLAVDPDDLERAAELTFVLDGETHTFCHVYVTETFEGQPRESPEARPEWVAIEEVPYDRMWEDDRLWLPGVLEGRTVRGEFAFEGGRPLDEAEFVGHDLEWDVPLSEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK56</accession>
    <name>A0A3N6LK56_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-oxo acid dehydrogenase subunit E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86738">
        <property type="protein sequence ID" value="RQG86738"/>
        <property type="gene ID" value="EA462_16520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="4">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="5">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="5">
        <location>
            <begin position="230"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="642" mass="68267" checksum="272789400B9E3CB9" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK68</accession>
    <name>A0A3N6LK68_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86758">
        <property type="protein sequence ID" value="RQG86758"/>
        <property type="gene ID" value="EA462_16625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="420" mass="46290" checksum="EBCB6EF1F577EF01" modified="2019-02-13" version="1">MTLFKLERNAEFEKLITHLEESSNPDIRKRSAEILGSLESETGGTNLSHDEVVDALVEASKADDDGRVRAAAIDALDQYGQDALEQFIGELSEQDIDDVAEWKKAQILARGLNAEQAELRMAAATGLGRIGEDNVLNQLVARLEDPDSRVRKRVARALARVESPECVPALSRNLHEDQYDVRVEVAYALADIGTQNALAELVEIADDDDEVLRRIAVDALGRLGSVEAVEILAGALSDETEMVRRTAMFSLVQLLSEAPPNASHQVREKIVDELEEANERDSVQPLIEILGRSTETAQRRNAAWLLGRIADDAFRTEAQDALIETLADDDEMTSKFAATSLALLDGDGLEQRLIKLVETDTKDEEMRVKALFVLGKIGGDRSRKRLSKFVERTESDRLRKRGFSALSKLGGMEMPSGDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK89</accession>
    <name>A0A3N6LK89_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86788">
        <property type="protein sequence ID" value="RQG86788"/>
        <property type="gene ID" value="EA462_16780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="93" mass="11035" checksum="2131426E5417FBC6" modified="2019-02-13" version="1">MYDLTGFQRDLLYVAAGLDEPHGLAIKDELEKYYESEIHHGRLYPNLDTLVDKGLLEKGTKDRRTNFYTVTRRGQREVEDRRGWEDQYVEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKD4</accession>
    <name>A0A3N6LKD4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89088">
        <property type="protein sequence ID" value="RQG89088"/>
        <property type="gene ID" value="EA462_11970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="271" mass="29785" checksum="41191465D1900657" modified="2019-02-13" version="1">MCYDWGERLFSSPHRLAVLRELYSEPADTQALTDSLPISRVTVQRHLNGCAELGWARKVDGRYELTPVGNHVCEAAATFLDRLSVLESSGDVIDAVATVDDRFDPILLANATVSVAEPDTPHEPIIHYRNAMAETTTDTVRGILPVFSELIVEVHRDLLASGVETDLIAPRPILETAPPSIAETPSTLFSLYVLEQPLEFGLTLTDDAAFFGAYDDGTFAVCIESSEPAFREWATDRYEHYLERARPVPLEADGSGVESTSVREFGTDAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKI7</accession>
    <name>A0A3N6LKI7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89168">
        <property type="protein sequence ID" value="RQG89168"/>
        <property type="gene ID" value="EA462_12435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035185">
        <property type="entry name" value="DUF5305"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17231">
        <property type="entry name" value="DUF5305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="378" mass="42175" checksum="3BD96CFA1B4BF784" modified="2019-02-13" version="1">MAAIDRGVRIRAFVQTWFAVGVVVLLLATLVGGWWAYQVNVVPDVAEEERLVEQWDESTAYDHSASIEQDSVPFEEGEVVSNRPIYYTNLSSGLNGTYTYGYSAEDGDVSVTTETLLLIRAGELEDQRVVETYWEVAEPLESTSADSVGPSDEHAVEFSVNVTDVLETIETVERQVGATEGLVDVRVVSVTDVDGTVEGESHADTYESEMIMVVDPATFRVIETDTITEDHPSFETVQLIAEPSPHEVYGSILLFTAAFVLLVALSFARIGGYTDLSENEQELLRLERDRAQYDDWITTGKFPSEREYEQTVLVDDLEGLTDVAIDTNKRVIEDTQLGVSTVLDDEYIYLYVHPNSPARDWLVNYADTTLEEFEANAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKL9</accession>
    <name>A0A3N6LKL9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86998">
        <property type="protein sequence ID" value="RQG86998"/>
        <property type="gene ID" value="EA462_15240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="63" mass="7396" checksum="131DE623890D45A8" modified="2019-02-13" version="1">MIESVTRRNGVEDAAGNATGDDERLAVRPNWEMSCEVNRRTSHGRDHRTRGRSERNPRRRPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLP8</accession>
    <name>A0A3N6LLP8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89808">
        <property type="protein sequence ID" value="RQG89808"/>
        <property type="gene ID" value="EA462_07250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="242" mass="26237" checksum="FAB2198138E50831" modified="2019-02-13" version="1">MTTTEPDRNSAHALGSTARPQALRTVLSSDRRRELLRLVARASPSGISKETLAARLCETGDVRSGSVTDEGRRKMLASLHHRDLPALIDVGLLTTADDGTIVATGHSLFDHLDILATEPPDGFEAVSDALAHSRRRSILAVLHRRNGSVSTRSLARAVTADESGFVVYPSSSDDVDDVYVSLVHVHLPILSDADLIAYDPDSGRVRYEGHPALSAGSETILERDRSITDDEFEIELLSRHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM60</accession>
    <name>A0A3N6LM60_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88847">
        <property type="protein sequence ID" value="RQG88847"/>
        <property type="gene ID" value="EA462_10630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="94" mass="10467" checksum="EDA69530AAF7007F" modified="2019-02-13" version="1">MSRPDPATSLNGVQTGHICDSCNKQIQHGDKVSMYATWYDEGGWTPRRTWCMKCCPGSVDPGTEGADEVIVEAVFWSHQLAGVRVKDRSRPIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM83</accession>
    <name>A0A3N6LM83_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MoaD/ThiS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88887">
        <property type="protein sequence ID" value="RQG88887"/>
        <property type="gene ID" value="EA462_10850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="98" mass="10551" checksum="D9A6F44C6B215A9F" modified="2019-02-13" version="1">MEIELRFFATFRDAVGQKERTGTFEDGETVGDVLSSLESEYEGLEGQLIENGAVRDQLSVLKNGRDVVHMAGTETTLEDGDVLSVFPPVAGGCVSRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMB7</accession>
    <name>A0A3N6LMB7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86655">
        <property type="protein sequence ID" value="RQG86655"/>
        <property type="gene ID" value="EA462_16035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="96" mass="11184" checksum="C95A39136F4FB7E4" modified="2019-02-13" version="1">MGTISTRVPDDLEGELEEYLDEERLDRSTAVRKLLSEGLEEWRRERALKRLAADEITFTKAARCAEMSVWEFAQLAKDRDITWVSDDHLEADLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMH6</accession>
    <name>A0A3N6LMH6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_09595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90228">
        <property type="protein sequence ID" value="RQG90228"/>
        <property type="gene ID" value="EA462_09595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="230"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG90228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="381" mass="42084" checksum="00D9298F3985BBDA" modified="2019-02-13" version="1">MDLELPDEHRMIQETVRDFCETEIEPVAQEIEDEHRFPTEIFDQLAELDMMGVPIDEQYGGLGGDTLMYSLVAEELGRVSGSIGLSYVAHVSLASKPLERFGTEEQKRRWLRPLAEGTHLGGWALTEPESGSDASDMSTTAERDGDEWVLDGTKQFITNASEAGSILVKAVTDPEAGYDGISTFIVDPREDDGFEVTTIWEKMGLNASPTCEIHLEEVRLPPDRLLGEVGDGWEQTKTTLDGGRISIAALSTGLAQGAYEHAREYSLEREQFGQPISSFDAVRDKIVDMHRKTERARLLTRRAARTADAGRPVTRESALAKLDASEAAREVAEDAVQVLGGYGYTTDFAPQRFYRDAKLMEIGEGTSEIQHLVIGRELGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMH9</accession>
    <name>A0A3N6LMH9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T2SP_E domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86745">
        <property type="protein sequence ID" value="RQG86745"/>
        <property type="gene ID" value="EA462_16555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="1">
        <location>
            <begin position="173"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="557" mass="63032" checksum="A246B35312D81B71" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMU1</accession>
    <name>A0A3N6LMU1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_12535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89187">
        <property type="protein sequence ID" value="RQG89187"/>
        <property type="gene ID" value="EA462_12535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="77"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1052" mass="112429" checksum="B9C2F5CFA6B8661E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP14</accession>
    <name>A0A3N6LP14_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Elongation factor 1-beta</fullName>
            <shortName evidence="7">EF-1-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">aEF-1beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ef1b</name>
        <name evidence="9" type="ORF">EA462_03955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91158">
        <property type="protein sequence ID" value="RQG91158"/>
        <property type="gene ID" value="EA462_03955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00043">
        <property type="entry name" value="EF1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004542">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39647">
        <property type="entry name" value="PTHR39647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006521">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="SSF54984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00489">
        <property type="entry name" value="aEF-1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF1_GNE" evidence="8">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="88" mass="9327" checksum="5E624FA5587DB288" modified="2019-02-13" version="1">MGKVAAKIKVMPNSPEIDLDVLQERLESSLPEGAKINGVEREEVAFGLVALYPTVIVPDGSGGTETVEENFTEVDGVESVGVENVGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP50</accession>
    <name>A0A3N6LP50_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88027">
        <property type="protein sequence ID" value="RQG88027"/>
        <property type="gene ID" value="EA462_14330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="153"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="289" mass="31591" checksum="7BE3893FAA24F227" modified="2019-02-13" version="1">MTTEIETDGLLLVPVANDETASRQLETAVDVARDRSYRIRLLYVLDVPPQLSLVDGRRYLLEDDTERMLADAVTEIETRGIPVDSRIRLARGITTGITGAIESYDADAVLMGWRGRPPRQNVVLGTHLDRVLRGAACDVLVERIKTPRPDVDSVLVPVVGGPHDEFATETGGAIARRRNADVTLLYVNQSDNPDRSLSEGESVLLDRSSLLEDVDSVERKLLEADDVAGTITDWTTEHDVTVVGVSRGGLIQRKLLGTISEAVGRHAAGSVILAKRHDPVPSRLKRLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPB6</accession>
    <name>A0A3N6LPB6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91278">
        <property type="protein sequence ID" value="RQG91278"/>
        <property type="gene ID" value="EA462_04630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="341" mass="38168" checksum="066D35B0D832F1B1" modified="2019-02-13" version="1">MNDSDSNEDSSGRDRLGGARLWMLLRVNRWAFTGAVLSLVFVILVATSQIGLTPLREIVENQDGLEFLFSAFIGAIITGTSIVVTINQLVLSQELGAIGDQRDRMQTSMQFQRDVEDTIDEDTSPPEPAAFLYELVDGVQERAAELEAEMEDERDEDLREKVAQYVAELDDNATEVKASLENAQFGTFDVIWSALNFNYSRKIYDARTIRDDHSDSLSEDANEKIDHVIDTLQLFGPTREHFKTLYFQWELIALSRALLYISVPALTAMAIMIMYVDASALPGTTLGVDNLVWLTSAGFVFGIAPFVVFIVYILRIATVAKRTLAMGPFILRESEREEDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPF9</accession>
    <name>A0A3N6LPF9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rps17</name>
        <name evidence="5" type="ORF">EA462_05070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91348">
        <property type="protein sequence ID" value="RQG91348"/>
        <property type="gene ID" value="EA462_05070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_A">
        <property type="entry name" value="Ribosomal_S17_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_S17_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019978">
        <property type="entry name" value="Ribosomal_S17_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="148" mass="16401" checksum="5A2B2236989818D1" modified="2019-02-13" version="1">MAIGLDVETPPEPDNPEEYDYEKCPFYGELPARGQILEGTVVSTDMDKTVVVEREYDVAVPKYDRYMKRRSRIPAHVPGVLEPLSLGDTVKIAETRPLSKTKSHVVVEITEEATAADVAELTRPGEPERELSSEDVTADADDEPEGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPH4</accession>
    <name>A0A3N6LPH4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="2">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">coaD</name>
        <name evidence="5" type="ORF">EA462_05195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91373">
        <property type="protein sequence ID" value="RQG91373"/>
        <property type="gene ID" value="EA462_05195"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00647">
        <property type="entry name" value="PPAT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023540">
        <property type="entry name" value="PPAT_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="159" mass="17797" checksum="8A9C6FF0BB4816EE" modified="2019-02-13" version="1">MDVAVGGTFDPVHDGHRRLFERALELGDVTVGLTSDEFAPKTRHTDRQIRPFEARAEILENELEELADEYAREFEIRPLEKPTGIATEPQFDYLVVSPETRDGGERINEIRVERGYDPLEVVAVPHVLAADGDLISSTRIIEGEIDEHGTVLSEDSDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPP0</accession>
    <name>A0A3N6LPP0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">lysA</name>
        <name evidence="6" type="ORF">EA462_05670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91453">
        <property type="protein sequence ID" value="RQG91453"/>
        <property type="gene ID" value="EA462_05670"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="38"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="278"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="409" mass="44176" checksum="8F390E125F1BECA3" modified="2019-02-13" version="1">MCDLADSPAVRRLTDWDASTLESLAAEYETPLYVIDLDRVAENYARFSTAFPDAEVMYAAKAHTGKAVLETILETGGDIECAAWGELQRSIDAGADPNTLQYTAVNPPDHDLDYATDLATDHPGLTITIGAIDTLERLADRGYDGRIAIRVNPGIGTGHHEKVATGADAKFGIPYERVPDVADRVRDGFDLVGLHAHAGSGVLTDGIEEHCRAIERVGAMARRVGDLEFVDVGGGFGVPYREDEKPLDLERTAEMVRDAVGEIDATLKLEPGRYVVADAGVILTEVNTIKEAPDTTVVGVDASLATMIRPAMFGSYHPMLNVSVPEREPHPVTVGGPVCTSADVFAHDRPIARPEREDVIAIGNAGSYGYELASQFHSQPRPGEVALEDGGHRIVRRRETLDDVTRVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPV9</accession>
    <name>A0A3N6LPV9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91563">
        <property type="protein sequence ID" value="RQG91563"/>
        <property type="gene ID" value="EA462_06300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="761" mass="85482" checksum="DA2EDC1BFA045AAE" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRP3</accession>
    <name>A0A3N6LRP3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acetyl-CoA carboxylase biotin carboxylase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_03610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91097">
        <property type="protein sequence ID" value="RQG91097"/>
        <property type="gene ID" value="EA462_03610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="1"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="121"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="534"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG91097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="609" mass="65590" checksum="C7FC6199C26CEC91" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRT7</accession>
    <name>A0A3N6LRT7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-CASP ribonuclease aCPSF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_07740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89894">
        <property type="protein sequence ID" value="RQG89894"/>
        <property type="gene ID" value="EA462_07740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019975">
        <property type="entry name" value="aCPSF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033769">
        <property type="entry name" value="KH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17214">
        <property type="entry name" value="KH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03675">
        <property type="entry name" value="arCOG00543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="98"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="194"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="3">
        <location>
            <begin position="423"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="644" mass="71679" checksum="8E496B190D80894B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS63</accession>
    <name>A0A3N6LS63_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92718">
        <property type="protein sequence ID" value="RQG92718"/>
        <property type="gene ID" value="EA462_00340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="6790" checksum="2624CCC5038D80D7" modified="2019-02-13" version="1">MLFPPTLDIGLLGVQGVQTVTAEEPIILEDSRGNLLEIDGELGPTVDRKLEVTGTGVSGERSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS75</accession>
    <name>A0A3N6LS75_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_00425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92733">
        <property type="protein sequence ID" value="RQG92733"/>
        <property type="gene ID" value="EA462_00425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="4">
        <location>
            <begin position="65"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG92733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="138" mass="14785" checksum="510C6898ED3E3194" modified="2019-02-13" version="1">MNTVVPPAGRQKRTDSTFVSRGHDSGTDAGPIVALVPEGAREVRITVRSDSVILTAPSQPSEPPETSLRNRFSGTIERLESGDAITRVTIRLDDDCTVQALVTKTSADRLELEDGKRILAAFKATAARAIALDADARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS98</accession>
    <name>A0A3N6LS98_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90134">
        <property type="protein sequence ID" value="RQG90134"/>
        <property type="gene ID" value="EA462_09090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="418" mass="43429" checksum="4053FF0BCF195C43" modified="2019-02-13" version="1">MSTEGRPAGATYAVSDLESASFVRLVTRADGDALAASGLVARALTARGTPFQLTVGRTVAERTRRVETATEHVAGAHDLTVAVGAVDADVSRLDVDDRPATLAAVDLVRDLEATPDPDPILALAGLVAAGVDPGAGESEWILETARDRGLVERRPGVAVPTADPVDGLAHSTRLRAPWSGDRDATHEALKSVGVETPTELDADDHRAIGSLAALDVVGADETSDVAAKSIQRVLRPYATPDAPFETLGGYADVLEATARSEPGTGAALAMGHDAREPTCSVWREYGRTVHAGLDRASTGRYDGLFVVDIDDGPVEAAARTVVAYRSPEPVVLAVGNGEAAIATRGGGAVGPTVERIARELEGAFDGSAGGEPGATAVDDRPDEAGVEYDVGHHRGYLRYDPSVDESTIIAIVREVSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSA9</accession>
    <name>A0A3N6LSA9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92788">
        <property type="protein sequence ID" value="RQG92788"/>
        <property type="gene ID" value="EA462_00735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="121" mass="13332" checksum="60EF7D178E2249CF" modified="2019-02-13" version="1">MDGEVSPDEVNELLEANSDVRIVDIRDERSFERSHIPDSENVPFHELTARIDEFEDADRIVTVCPHGKASVQAAKLIGSYEGSADARVESMAGGLEEYGMRYGLVREDGDGDSTTEPESPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSE4</accession>
    <name>A0A3N6LSE4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-ketoglutarate ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92848">
        <property type="protein sequence ID" value="RQG92848"/>
        <property type="gene ID" value="EA462_01080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="3">
        <location>
            <begin position="61"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="311" mass="34474" checksum="B7ADF3BC1C17A7E2" modified="2019-02-13" version="1">MSAFNAIGDEREIDRDEFTPGVEPQPTWCPGCGDFGVLKALKQALPEAGKTPEEVLTVTGIGCSGKLNSYLDTYGFHTIHGRSLPVARAAKLANPELEVIAAGGDGDGYGIGGNHWIHTARENHDMTYIVFNNEIFGLTKGQTSPTSPKGHKSKTQPSGSAKTPLRPLSMSLNAGASYVARTAAVNPNQAKEIIKEAIEHDGFAHIDFLTQCPTWNKDARQYVPYVDVQESDDYDFDVHDRKEGAEMMRETEDVLNEGTVLTGRYFVDDDRPSYQQEKKAVGEMPEEPLAERYFDDDAEWERSYDLLERHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSE5</accession>
    <name>A0A3N6LSE5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SprT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90194">
        <property type="protein sequence ID" value="RQG90194"/>
        <property type="gene ID" value="EA462_09405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="190" mass="21823" checksum="B5063355B6937E46" modified="2019-02-13" version="1">MTDGEQLTIDDEIVARARIHARTVLDEYDLSVDRDALEWETSLRARRRAGACRWDPNREIATIILARRAYERYDWPTFAGVVRHELVHAWEYQRFGESGHGARFRERAAALDAPRHCQSFSEPRYVLRCRETDCDWEATRHRASKPVKSPDRYRCGSCGGSYEVEHAESGRTWTTASGYGGSKAALGDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSH7</accession>
    <name>A0A3N6LSH7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92893">
        <property type="protein sequence ID" value="RQG92893"/>
        <property type="gene ID" value="EA462_01340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="297" mass="32002" checksum="3D1812B2BC5AD51A" modified="2019-02-13" version="1">MVDRRDTMNDVSVIGCGGIGTAFVETLAGEGVNVIAWNRTREKAEALAGKQVEVADSPGDALEASRTTLCCVSDHPTMMDILEDASDRIDGTTIIGVSFATPEQATEANAFMQDFDGHYLDMAVLAYPRLVGTDTGHFFIAGDSRAYEAARSILDHLGTVTYIDGPPGSAFLRESVVFLPFLPMAVSMVQSAHIAEAMDIPLAWVGERFRALYPAFIDITFETIQSGMDPADPANVDASVQVWSAGAEEYACFLDEMGLDTGMYEALHRLFEAGVADGRGDHDWVSVTELRADQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT60</accession>
    <name>A0A3N6LT60_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster assembly scaffold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93203">
        <property type="protein sequence ID" value="RQG93203"/>
        <property type="gene ID" value="EA462_03130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="139" mass="15354" checksum="AE41A049DB0E401B" modified="2019-02-13" version="1">MGLGSDMYRQQILDHYKNPRNYGTLEDPTFTHIGENPMCGDEIRMDVELAEDDETIERVAFSGDGCAISQASASMLSGELAGKSIDDLLEMDRDDIVDMLGVDISPMRIKCAVLAEKVAQDGAEIYRGELEKEKTSTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVR6</accession>
    <name>A0A3N6LVR6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NDP-sugar synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92867">
        <property type="protein sequence ID" value="RQG92867"/>
        <property type="gene ID" value="EA462_01185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="323" mass="35951" checksum="3A2181E528E8E908" modified="2019-02-13" version="1">MKAVVLAGGYATRMWPITKHRPKMFLPIGESTVIDRIFAELEADTRVDSVYVSTNERFAPDFEAHLAESEFEKPQLSVEETTEEDDKFGVVGALAQLIDREDVDDDLLVIAGDNLISFDVSDFLDYFERQGTPTLAAYDVGSREKAKSYGLVELEDDRVVDFQEKPADPKSTLVSIACYAFPRDSVSLLSTYLEEGNNPDEPGWFVQWLQNREPTYAYTFEDAWFDIGTPESYLDAVSWHLDGDSLVAESATLENATIGENVHVMNDVRLEETNLDHAVIFSDATVQNGDIRRSIIDEGTHLEDLDLAGALIGAHTTITNGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVZ3</accession>
    <name>A0A3N6LVZ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92967">
        <property type="protein sequence ID" value="RQG92967"/>
        <property type="gene ID" value="EA462_01765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="71"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="206"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="416" mass="45671" checksum="5653B9A85337466F" modified="2019-02-13" version="1">MDHDELVSTFGQTVGIEKARSLIQQTLAELDISPAESYSSHEVADICETIGHRTDGYLEIVATEIQAREKAHRRFDTLVEEIPDPVVTVSFDGSVPTVTGLNPAFEATFGYGTEVIGRSLPELIAPEDADSEPVDVWFRSDTDGGVEVDRLTAERERRTFIFQPVIVSGFDGEIEGYGVYTDITDRKRRERRLTRQNEQLERFVSVVSHDLRNPLTVAQGNAELARSSLSDSDAAEHLEEVISAQDRMESLIDDLLALASQGRIVDDPGPVRLTNVVSKSWHYVETADARLVEEFSGDVTIEADGDRLCQLFENLFRNAIEHGRADDPVTGEPTVTVRVGWDEGVLFVEDDGPGVSADEREEVFGHGYTTSQEGTGFGLAIVDAIADAHGWTIDLVDGRVGGARFVIHGVSVVRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYQ3</accession>
    <name>A0A3N6LYQ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93004">
        <property type="protein sequence ID" value="RQG93004"/>
        <property type="gene ID" value="EA462_01980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="133" mass="15369" checksum="34DB13E76899F410" modified="2019-02-13" version="1">MGNKNKTISFRVNEDAFEALQDIATERDISLSAVFRDYVDLLVDHDGQVTVVPDHELETGASDDGDRSFPPTVEVPKSFIREHERLELEAEHLREQLDEYNAYVTDLQDRLEGEEDEILLLDDLDDEESYQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ51</accession>
    <name>A0A3N6LZ51_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoesterase</fullName>
            <ecNumber evidence="1">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93174">
        <property type="protein sequence ID" value="RQG93174"/>
        <property type="gene ID" value="EA462_02935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020935">
        <property type="entry name" value="PdiEstase_YfcE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01269">
        <property type="entry name" value="UPF0025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="222" mass="23949" checksum="EA61628019DE5933" modified="2019-02-13" version="1">MKVGLISDVHGNLVALEAVLAEMPPVDEVLCAGDVVGYNPWPGECIDELRGRDVPTVMGNHDAAVVGDAPFRFSGMARAGVEHAESVLSGAQLEWLESLPIERTECDGRVKLVHGHPDDPDRYTRYTYPKEFSPRMLGDEDVLVLGHTHVQGASQYAEGIVVNPGSVGQPRDGDPRAGYAVVDLEALTVDTHRVEYDIEAVQSAVAETDLPEQIGGRLSRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ57</accession>
    <name>A0A3N6LZ57_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phage tail sheath family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_14240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myoviridae tail sheath protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88013">
        <property type="protein sequence ID" value="RQG88013"/>
        <property type="gene ID" value="EA462_14240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035089">
        <property type="entry name" value="Phage_sheath_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020287">
        <property type="entry name" value="Tail_sheath_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04984">
        <property type="entry name" value="Phage_sheath_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17482">
        <property type="entry name" value="Phage_sheath_1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_sheath_1" evidence="3">
        <location>
            <begin position="295"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_sheath_1C" evidence="4">
        <location>
            <begin position="464"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG88013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="577" mass="62222" checksum="704616391FB50882" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZZ3</accession>
    <name>A0A3N6LZZ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rubrerythrin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88900">
        <property type="protein sequence ID" value="RQG88900"/>
        <property type="gene ID" value="EA462_10930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="51" mass="5517" checksum="009BEF8E46845790" modified="2019-02-13" version="1">MPHEQDVEGDTADIDSEFECLQCGTIVTAETHPGTCDDCGGDFQNRAKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0K3</accession>
    <name>A0A3N6M0K3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88094">
        <property type="protein sequence ID" value="RQG88094"/>
        <property type="gene ID" value="EA462_13220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG88094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="306" mass="32087" checksum="D9A235B325B82781" modified="2019-02-13" version="1">MIESAIRFVYLSLSIASVYILVAIGFSIAYGSLKFVNMAHGALYLLGAYIGLFIAFEPTVGGTLGNYSPIGLALGFTAAIVLVPIILFGIGVVMERLIAKPFYERDMLDQLLVTFGILIIIQELVAVLVGRGGLSYARPDWATGAVSVSGIVSASRWRLIVIALTALFLILLYAFYKYTDFGLAVRAGTEDAEMVEMLGIKISRPFALIFAIGAGYAGLAGILGGSIFTVQPEIGLDILIPALLVVVMGGVGSITGTILAGLLVGATFTATASVYPEMATASIFLLAIIVLSIKPSGLFGTDEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0R1</accession>
    <name>A0A3N6M0R1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lasso peptide biosynthesis B2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89230">
        <property type="protein sequence ID" value="RQG89230"/>
        <property type="gene ID" value="EA462_12760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Transglut_core3" evidence="2">
        <location>
            <begin position="59"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="160" mass="17545" checksum="8DC17A780720ECB1" modified="2019-02-13" version="1">MGRLSGFLSISAGDKVRVVVAATLLLIVQFGFAFVSFSSLRRVLLGVSTTLSRIVPGIPAPIRIAWAVEATDRNVPGKRTCLMRSLTSETMHRLYHHDIIHRIGVDPSGTDADDLETVTVSRGTFEAHSWIEHEGEILLGDLEDLSRFEPLPPLNGADDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1V5</accession>
    <name>A0A3N6M1V5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89770">
        <property type="protein sequence ID" value="RQG89770"/>
        <property type="gene ID" value="EA462_07055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="357" mass="39377" checksum="A4EFF82E96FB832B" modified="2019-02-13" version="1">MTTNLKDIRTGIVGLGNIGQYHAERLVELGVPLVGGMDISPEARKRFARRYDVDVYDDHTELYDTVDALVITTPNKYHEEYAVDALECDRHVLLEKPLAHSLDSARRIAEAAAAADSRCMVGFNNRFANTVRIVSDRIDRGELGALSHIEANYVRRRGIPGRGTWFTRRQIAGGGALIDLGVHAIDLALYVLDYPPVEEVSGVTRSEFGSRSEYAYLEMWAEDAGPGGFDVDDSASAFIRCAGGKTISLEVAWATNRPENHEFVIRGTDSAARFDLLDGDLSFYSAKKHGPDHLENTVIETPQNDTHSDEQAAFFDRIIAGEDDQSVEQALVVQRVVDAIYSSSELGASISMDEYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2N9</accession>
    <name>A0A3N6M2N9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Geranylgeranyl reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90080">
        <property type="protein sequence ID" value="RQG90080"/>
        <property type="gene ID" value="EA462_08760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="495" mass="54726" checksum="657CADF9240D59EB" modified="2019-02-13" version="1">MVRNQYGVVVVGGGVAGCFAAATAAAEGIDVVQLERKPREEGGFIACGDAMKSPRNPKNYPGPIDMDAIAGDESVLVDNNIDQIEFWDEELGVRKVLPYETGSNVIDRYEFGQRLLEQAADRGAEQHYDTVVNEVIQTDRVTGVDAIRNGDPVSYECDVLIDAAGAQSILQDMIDFEGLDTSGDPTFEVPHYTHFGSAYREIIETEKPVEYHNAIVGKPLERMGYIWYFPRTPTEINVGLGFQMNTEPIPLADRLRRDIENRPEYQDATVSDRFERKNKLGAAIALRRPLDSMVAPGYLAAGGAAGTTHPITGKGIRGAAYSGYSAGRAAAQAIEDGDVSESGLWEHNRFLYREHGEAAKLASWDAYNVAASSIEVNVLRAVTALLPERELREIVGTSTKVDSLKSKALVGTGVLKNFVSEYRRGSFDALDVGTGELYEAVRSVRTTRTYVSAYENQYEAYPEERSTFEDWLSERDRIDREFYDALDLSPGDYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3D8</accession>
    <name>A0A3N6M3D8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86213">
        <property type="protein sequence ID" value="RQG86213"/>
        <property type="gene ID" value="EA462_17095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043860">
        <property type="entry name" value="DUF5822"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19139">
        <property type="entry name" value="DUF5822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="80" mass="8738" checksum="BCEBBD962672EFDE" modified="2019-02-13" version="1">MPEPVETTTPDGVDYGWVMQVTFVVTIVVGAPIVALLSLSAELPTWGVRAEFAIRVGAPIWFATAVVVFVYAKRTRTDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3U5</accession>
    <name>A0A3N6M3U5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferritin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86797">
        <property type="protein sequence ID" value="RQG86797"/>
        <property type="gene ID" value="EA462_16830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="177" mass="19834" checksum="B0D4C659332183BD" modified="2019-02-13" version="1">MLKNSIEDALNEQINEELYSSYLYLSMAAYYEDEGLPGFASWMRSQADEEHAHAMRIYEFVVERDGRITLEGIDSPPTEWNGPADAFEAAYEHEVEITRMIDELVGLAREENDNATENMLQWFVAEQVEEEATAQGILDKLNHVGDDGPGLLMIDQELGQRGGDGAEDESSAPESPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M459</accession>
    <name>A0A3N6M459_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86937">
        <property type="protein sequence ID" value="RQG86937"/>
        <property type="gene ID" value="EA462_14865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="96" mass="11315" checksum="214CBCC38D8DC390" modified="2019-02-13" version="1">MWSARNRTEAVTCLACGDEVSRSRAREYDKHGDRWNRADKTFEHLCKRCDDELCRHPRDELEELLVELEAGTDGTSRFLTAYFRAVEERYGSLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4H0</accession>
    <name>A0A3N6M4H0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90131">
        <property type="protein sequence ID" value="RQG90131"/>
        <property type="gene ID" value="EA462_09070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="185" mass="19195" checksum="233FE72CECE5AAD4" modified="2019-02-13" version="1">MATSSQTADEIEIEVARPTEEQSFKERIADVATVGGISGAGDAAIAANEHAEEVADQHFDNVLINGIMTVLIGGILLTLAGVIITDFVEIMPEEGFMDQGDITSPLSTALGLTAISLVVPVVAGVVALLMGSFGGFMGTAVESALENANAASVIFYEAHGNAGIADTRCCPGSNHNHRTVRVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4K9</accession>
    <name>A0A3N6M4K9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="2">N5-CAIR mutase</shortName>
            <ecNumber evidence="2">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purE</name>
        <name evidence="5" type="ORF">EA462_15830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87097">
        <property type="protein sequence ID" value="RQG87097"/>
        <property type="gene ID" value="EA462_15830"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="4">
        <location>
            <begin position="26"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="212" mass="22722" checksum="E3E29F8644E817C5" modified="2019-02-13" version="1">MSDSVRDLIDRLHREADQDRPPAETPDVGIVMGSDSDLETMMTGGTRPGAYDAFVDELDFAEQTAFDAPPEERFTFETYVTSAHRTPDLMTAYAETAEDRGLEVIIAGAGGKSADLPNMTASIAYPLPVIGVPVQEKSVDSVIGMPAGAPLVAVDAGKSFNAALSAAQILARSHDAVRDRLISYHDRLREGVGDVSRELHDGGITSFRDRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M519</accession>
    <name>A0A3N6M519_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein gvpF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_07510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90351">
        <property type="protein sequence ID" value="RQG90351"/>
        <property type="gene ID" value="EA462_07510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="207" mass="23289" checksum="6EBF09C2C12700C2" modified="2019-02-13" version="1">MNNRYVYGIIDGEPVEFDAQAVGGADRVYTISHRRLGAVVSDIETTDPEETDEDATRHDEVLRTVMDFDGGRPVVPMQYGMAFESDRALKNVLRGARPAFRRALNDVEDRVELGVKIVRDEDAVVDADEIDATVESRLEPIAAQSVPNDLFSDRLVLNRSYLVERDEREMFDEAVARFEDDHDDLTVQYSGPFAPYSFVDVAIGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5D0</accession>
    <name>A0A3N6M5D0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91220">
        <property type="protein sequence ID" value="RQG91220"/>
        <property type="gene ID" value="EA462_04310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013971">
        <property type="entry name" value="HalX_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08663">
        <property type="entry name" value="HalX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="199" mass="22545" checksum="21A0AB1D7E144ED8" modified="2019-02-13" version="1">MATDHSSVLIVEDEPDLADLYASRLEDEYDVQISYDGNQALESIDEGIDVVLLDRRMPGLSGDLVLETIREQRLDCRIAMVTAIEPDFDIVSMGFDDYLVKPVSKAELIEVIEGLLLRSAYDEQLQEFFAVSAKKVLLDGRKTEAERLTSQEYARLEDRIAVLRVRLEETTSELADGDGYRQLCMDISQQQSTEDRTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5E9</accession>
    <name>A0A3N6M5E9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ORF">EA462_13890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87949">
        <property type="protein sequence ID" value="RQG87949"/>
        <property type="gene ID" value="EA462_13890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="3"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="193" mass="21233" checksum="8832AB63E076DAD5" modified="2019-02-13" version="1">MPKRIVIGMTGATGQIYGIRALQLLQETEYEVHLILSNAGKINVTQEADYEVSEVTDLADVVHDVKNIGAETASGSFQTEGMLIAPCSMKTLSNIAHGSSGDLITRSADVALKERRPLVLMPREKPFNRIHLKNMLEVTDAGAIVFPPFPSFYQGPMNLDDMITRTTARALSQLSVRIEVDEWEGLDSTNETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M704</accession>
    <name>A0A3N6M704_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_12145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89116">
        <property type="protein sequence ID" value="RQG89116"/>
        <property type="gene ID" value="EA462_12145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043795">
        <property type="entry name" value="N-alpha-Ac-DABA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039012">
        <property type="entry name" value="ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="318" mass="34034" checksum="A59658BA33BC8E1B" modified="2019-02-13" version="1">MTTLGTARAGPGEIDTGRLEVGETRDGSPFGLPVAVINGAQSGKTLYMQAASDGDELNGVGVIQRVVPRLDPAELSGEILIVGIVNYHAFQVAEHRNPIDDTKMNRTYPGNETGTSSERIAAATFDAATRADLVLDLHQGSTSRMVDEVRVRCGKRHRLYDECLELAKTFGCGYVLDQKGPDGQLARAAPNEGVPTVDPELGGCVGWDEESIRAGVEGVFNVLNYYGFLEGTVDRSRQTRANGFEQYGAPSGGLVTMKADLGEQVSAGQTIFEVTTPFGEPKATVTADSRGVLWRIRRLPQVATGEYVCSVGTDVDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M720</accession>
    <name>A0A3N6M720_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA primase large subunit PriL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">priL</name>
        <name evidence="9" type="ORF">EA462_12250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89136">
        <property type="protein sequence ID" value="RQG89136"/>
        <property type="gene ID" value="EA462_12250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06560">
        <property type="entry name" value="PriL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00701">
        <property type="entry name" value="DNA_primase_lrg_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023642">
        <property type="entry name" value="DNA_primase_lsu_PriL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="PTHR10537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0639">Primosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="362" mass="40962" checksum="ED4723ECB43CDCE1" modified="2019-02-13" version="1">MQRLHARYPFLEAARETVATEAVDLATVVEDDRAVVDRARQRVITALEGEGIGEPHRTTRIELLSYPVARVLVSMVGERILVRRYARGEAETAYDRFKNDRDDTTELKSVETTALDLADLRAEFEMDEAVRSSSTESYRIDVGTYLPLAANLWGDEWLLVNQPVADGEVPVSEDELLVLLREAIRNRIEDGLPFEVPESIASALEDDAEEIRRALAELDLTREIDTVVPDLFPPCMKALLDDIQKGEHLPHHSRFAITAFLANIGMSTDEIVDLYRVNSSFGEEMTRYQTDHIRGDTSPTEYSSPSCATMQSYGDCVNKDDLCERIPHPMAYYEERIDDAEDDELEDWRESEGEEEGEPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8J3</accession>
    <name>A0A3N6M8J3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">flpA</name>
        <name evidence="5" type="ORF">EA462_04060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91691">
        <property type="protein sequence ID" value="RQG91691"/>
        <property type="gene ID" value="EA462_04060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="212" mass="23399" checksum="F68F680CA8D51E29" modified="2019-02-13" version="1">MSEPTLPEGVERRTFDGSDRLATRGEAVYGEPTDGEWRAWNPDRSKLGAMFELGMETGLRGDETVLYLGAASGTTVSHVADFAGPTYAVEFAARPARDLLDAAASRPRLFPLLADARKPATYAHVVEADVDAIVQDVATRGQARVALENRRFLADDGRLLLAVKARSEDVTRDPEDVFTDVETELDEGYEILERRRLEPYHADHLAVVARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8L7</accession>
    <name>A0A3N6M8L7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IIA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91721">
        <property type="protein sequence ID" value="RQG91721"/>
        <property type="gene ID" value="EA462_05910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="260" mass="26877" checksum="60F54B28CE0EECBE" modified="2019-02-13" version="1">MTDYEGVILDVDGTIVLGSELIPGAIEGISALEDASCSRLLFSNNPTRGSDHYGDKLDPHGIDVGPDTVLTSATVSASYLSETYDDERVFLVGGDRLASILDEAGVSLTDEPAEAEVVLGSFDRAFSYEGLSAALDALENGVPFYGTDPDATIPVDGGTIPGSGAILAAMEAVAGREPDAILGKPSSIAASAAKRRLEIDAEDTLVVGDRLDTDIALGEQAGMTTALVLTGVTDRSAVASSPVKPDYVLDSLADVERILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M911</accession>
    <name>A0A3N6M911_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92750">
        <property type="protein sequence ID" value="RQG92750"/>
        <property type="gene ID" value="EA462_00520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="145" mass="15922" checksum="EA0FA5B63BAD203A" modified="2019-02-13" version="1">MADRISSDHPSVQTVRSTCTETTTGVALVISAADRDAFSIDDVVRFVLDRDQRFARAERALTGDELTIRGVYETPQGARDPGDETDRLEQWAVEAGIQPGGSVLIDVVEPGFLYGLRKPGKTAYYDAYEPPSDSLSEIARNLDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M986</accession>
    <name>A0A3N6M986_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92840">
        <property type="protein sequence ID" value="RQG92840"/>
        <property type="gene ID" value="EA462_01030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="90" mass="10171" checksum="CCA746AE19A579FA" modified="2019-02-13" version="1">MFGAIGYGYIDPTVQQVIDEYGYGKFHAAASIYEAAILDGELDYSFGEMFPSIPHRDLAPIKRAYKYAYGRLSVDPLWGKTYDIECTTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9G4</accession>
    <name>A0A3N6M9G4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90166">
        <property type="protein sequence ID" value="RQG90166"/>
        <property type="gene ID" value="EA462_09260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="207" mass="23059" checksum="358C05830FDAF472" modified="2019-02-13" version="1">MSEKTNNPITAELPESPFHTTGTDHITIWGSNEEDTVAFYRDLLGMPLVLRQPNLDDPSQTHLFFDTGDGRILTFFVSDDRPSNRRGQRGGVGAVHHLCFSVDPDEYEDVMNALEDAGHRYNVFDRGIFHSIYTNDNNGLVIEISTDKYEIPNDRRAEVLATAQRLREEDGSDYAKDEHLSGAIEELGLEVVKHDLPDASAGVGGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9H5</accession>
    <name>A0A3N6M9H5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6 9">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="1 6 9">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pgk</name>
        <name evidence="10" type="ORF">EA462_01535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="1 6 9"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92930">
        <property type="protein sequence ID" value="RQG92930"/>
        <property type="gene ID" value="EA462_01535"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <begin position="357"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG92930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="402" mass="43945" checksum="B70852FC73C66C36" modified="2019-02-13" version="1">MPTFTTIDDLEPAQRLLVRIDVNAPIEDGTAQDNRRFARHAETISELLEDGHALALLAHQGRPGRDTFVSLESHADVLSAHLDREVAFVSDTFGEEALEAIRDLEPGDVLLLENSRMCEGELPEEEPAVKAETELVRTLAPEFDAYVNDAYSAAHRSHASLVGFPLVMDAHAGRVMETEYTANSAIRDREFDGTVTMVLGGTKAEDLIPVIEQVDDTVDRFCLGGIVGELFLRADGHDVGYDVDGTEFFDHQWADHRETIERVRSEYGDRLLLASDLAAESDAGERTEAAVENIEKETSYLDVGSETARRYADLVRESDAVFVKGALGVFEDERFADGTVSVLSAIAETDCFSVVGGGDTSRAIGMYDLEEKDFSHVSVAGGAYVRALTGDSLVGIDVLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9N5</accession>
    <name>A0A3N6M9N5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90246">
        <property type="protein sequence ID" value="RQG90246"/>
        <property type="gene ID" value="EA462_09695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRTGG" evidence="2">
        <location>
            <begin position="244"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="380" mass="41061" checksum="A6EE691028DA1FB7" modified="2019-02-13" version="1">MTDTQSEPEPEAESKTEREAEPEPKTGTRPKPILVASLSESTGKTAITLALARLARVDGQRAGYMKPKGTRLQSDVGKTLDEDPLLARELLGLEAEIHDLEPIVYSPTFVEQAIRGRENPDELRTRVREAYETLSADHDRMFLEGGGEYGIGGIVDLTDADLAELLDARVVLVAPYGVPADIDDVLGAVEDFGDRFAGILFNDVHDAAYDQLETDVVPYLENRGVRVFGVIPSERRLSGVTVGELADELGAELLVEAGTDAYVERFSVGAMGADSALRRFRRTKDAAVITGGDRAGIHTAALEAPGVRCLILTGGHRPSGSVLGRAATKDVPILSVRTDTLTAVERAEDVVRSGRTRDEETVDRMTELLADHADVESMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBC0</accession>
    <name>A0A3N6MBC0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="9">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA wyosine derivatives biosynthesis protein Taw1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">taw1</name>
        <name evidence="12" type="ORF">EA462_00575</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TYW1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92761">
        <property type="protein sequence ID" value="RQG92761"/>
        <property type="gene ID" value="EA462_00575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01921">
        <property type="entry name" value="TYW1_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023993">
        <property type="entry name" value="TYW1_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="PTHR13930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03972">
        <property type="entry name" value="rSAM_TYW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="73"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG92761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="353" mass="39749" checksum="2D41F43488DA8831" modified="2019-02-13" version="1">MSDSADSGAQAASDGHQDGGKRNDGDGSDDGDGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKNIYYGIESHRCIQMTPVVRCNERCVFCWRDHKGHAYEMDDVEWDDPEAVVDASITLQKKLLSGFGGNDEVPREVFDQAMEPRHVAISLDGEPSLYPYLPELIEAFHDREITTFLVSNGTRPEMLRECDPTQLYVSVDAPERHTFDQVVKAMEDDAWERLLETMDVLAEKDDTRTVLRTTLVDGENMHHPDWYAGFYQQADPDFVELKAYMHVGHSRGRLDRSSMPTHEEVIEFAESIKEYMPAFTECMGVPASRVALLSKTRDTWVPKLEKDSEFWARDPVTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MG58</accession>
    <name>A0A3N6MG58_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92916">
        <property type="protein sequence ID" value="RQG92916"/>
        <property type="gene ID" value="EA462_01460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="127" mass="14564" checksum="4BDD2981BF601B40" modified="2019-02-13" version="1">MCVAAVERRRTDRSRSERSLDAGLRLEDPVEPVERSLVEHRSPRALAVAAGPVGVCELDVPRGRRNRRRQIARLDREPIGFVTGDERGEPRPTRPSRTTRRTSCRSRRLRSGVRQYRRNREPSAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGY9</accession>
    <name>A0A3N6MGY9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93256">
        <property type="protein sequence ID" value="RQG93256"/>
        <property type="gene ID" value="EA462_03430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="82" mass="8427" checksum="41290975BADD480C" modified="2019-02-13" version="1">MVDDDPPPSETDRSATTPLGHHVVSVLRLAAISLVVVGFSGWVIDHGGEIALESPFTIAFGVGVACAFASIYLGIFLADGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRT9</accession>
    <name>A0A3N6MRT9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_15215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86993">
        <property type="protein sequence ID" value="RQG86993"/>
        <property type="gene ID" value="EA462_15215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="33"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="365" mass="39500" checksum="BE94E17B5D6D359B" modified="2019-02-13" version="1">MRASTRASRVTTVDPDCVRTVERVPHGGEPDRDVLDFSANTNPHTPPGVEAVYENALAESTRYPDDAYPEFRAAAAEFVGCDPASVIPTAGGLAAIRLAMAITLGPGEEALVPYPSFGEYARELRLQGGKPRLVRYDELCDLEPAVLESVSFAVVCRPNNPTGDAVGLDELAAFATRCREAETTLLVDEAFLGFTEFPSAVELETENVIVARSLTKLFGLPGLRAGFAVATGEDRDALETGRRAWSLGTPAARVGSYCLRQDEFVAETRTRVRQERERLRDALEERFSVHPSDAPYLLCTLEEGNQDVSSLVASAREKGVAVRDATTFRGLDAHIRVAVKDRDANDRLLASLGVGETNTDGDGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MT55</accession>
    <name>A0A3N6MT55_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ParA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87965">
        <property type="protein sequence ID" value="RQG87965"/>
        <property type="gene ID" value="EA462_13990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="291" mass="32190" checksum="AD34F217F4271CFA" modified="2019-02-13" version="1">MLAYSTYSEAGGVGKTTTAANLAVAHARAGLKPLVIPLDPQDGDLSRLFGVDDDRTESVDNLVRHMIRRPKGEFDDLVRTVEGVDIVPEHNMLSDLTEYLQREKDQAEAMGEAFGMHAQLLRVLREAGVPETYDVLICDPPATEGPHLYNAIHATRSLAIPVEPSAKGRAAVEGLESLVAGLEDQLDVEVGVLAAIPIGFKNTRDQRTILDEIEYPVPEVIGERASLMEGCWMQQCSAFRYVRDHRERRREYELETLAQFDRIARHLESSVDLEAPNPPEPGELEPEVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MT81</accession>
    <name>A0A3N6MT81_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87995">
        <property type="protein sequence ID" value="RQG87995"/>
        <property type="gene ID" value="EA462_14150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="441" mass="47537" checksum="4A97D195FE201063" modified="2019-02-13" version="1">MPEYTAGSVSNADVEHQYEEYLMPIWKSLNVPVKRASNCVLEDFDGNEYLDLYSGISVTNVGHNNDAVVEAAKDQLDEFVHGCTYVHPHRPAGQLAEKIARITPGELEKTFFCNSGTEAVEGAIKLARKYTGSKEVLALEMSFHGRTLGSLALTGNTSYKAEMAPTINDVSHVAPPYGYRCQRCSGTTCTATCAEQLERVIDTHTSGDLAAVILEPVMGEGGIIVPPVEWIERVQEITHDHDALLIADEVQTGYGRTGEMFASEHFDVVPDILTQAKGIANGLPLGAFTASSDVANAFESGDHLSTFGGNPVTCAAALATIEELEGGILETARANGKWFESQLEELEAEYDVVGQTRGLGLMHGIEIVDPDDGHGPMGVSPAPDPVLAGNVAKRLRKDGIVMGVGGFYKNVLRIQPPLTIGREQLDRTAEELREAIQREVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTC2</accession>
    <name>A0A3N6MTC2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin molybdenumtransferase MoeA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88045">
        <property type="protein sequence ID" value="RQG88045"/>
        <property type="gene ID" value="EA462_14435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="181"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="408" mass="44366" checksum="8475D08B307F673A" modified="2019-02-13" version="1">MGHDHSDMIWRRTAVESVLEMRSSVLSERETRSVPLESIERRTLAESIVAERDVPAHDHATMDGFAFDATDEYPLAVIADEVFPEDEPPSIDPGEAVPIATGAPLPPEANAVLKREDSSLEGDQLRGTTLEPGTYTYERGSNLSEGDRLFERGERLSPKDAILLGDLGRETVEVYEPFSTAVLATGTEIHEGRITDLDSDMLAGLIRSWGHDPTYEGSVPDEYERVEDSIDRLANQYDVVLTTGGTSVGHKDHVIRALDALGEVVFHRVRIRPGKPIAMATLPDHDAVAFAIPGKPIGAHTISTFVMRPFFTGTTSLPTVGARLTHDLELGPDGFEYVVPVTLEETEDGYETTALGHADSPLSVYDSQFDPSVLSSSTRASRADGVVLTQSPLEAETTVSVLPYSVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUU1</accession>
    <name>A0A3N6MUU1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89172">
        <property type="protein sequence ID" value="RQG89172"/>
        <property type="gene ID" value="EA462_12455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="187" mass="19177" checksum="8036F8C7B7569B21" modified="2019-02-13" version="1">MGITRRNTIIGLGVLAGGAGLIGGSGAFDSVEANRSFDVSVEGDAGGLLGLAVTDSIIATTESAGAGENDVIAFDLEDADDGSDRALNENAVTDFYSVFDMTNNGSQTVEVSVDTGEANGVSFVVVEERADNGSVVGEDVDLEGDTVELEPGETVSVDISIDTTDGGYTESEDEDPYQMTITAESTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUZ8</accession>
    <name>A0A3N6MUZ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89232">
        <property type="protein sequence ID" value="RQG89232"/>
        <property type="gene ID" value="EA462_12775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="162" mass="17538" checksum="591B43958FC208E5" modified="2019-02-13" version="1">MPDLLTHVLVGYIIGTIVVLRCEWAGSPHVTMVMIGALVPDFKKINLLVSDATVSDLLGIPWGWMAIHTVGGSVVIILLGSMLVAPGHRRRVIALLAIGATSHLFLDLLVITWSGEAFPVLWPVTEYRPPSGGLFRSSDRWPALATLTAAAVLWAVRRRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MV07</accession>
    <name>A0A3N6MV07_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="11">5.4.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glmM</name>
        <name evidence="11" type="ORF">EA462_12825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="11"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89242">
        <property type="protein sequence ID" value="RQG89242"/>
        <property type="gene ID" value="EA462_12825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="155"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="252"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="365"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG89242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="442" mass="47274" checksum="614A6AA24D2A4596" modified="2019-02-13" version="1">MFGTSGIRGTVGSEVTADRALSVGRALASDGYDRLVVGRDARESGRFLTDALTAGIRECGGDVINIGVASTPTVARSVAPLEADAGVVITASHNPPEDNGIKLWQPSGQAFDEERRNAISERVREERVSLVPWNEIGERTRHDAERARRRHRAAIRESVTAAGLEELSVIVDVGNGTGGITADVLYELGCSVRTLNGQPDGRFPARPSEPNEETLETLERTVGATDADLGIAHDGDADRMVAVDERGEFVPKDVLLALLARETASDGDRVAAPLNTSLALDDALETVGASVTRTPVGDVYVAERATEADVVFGGEPSGAWIWPNETLCPDGPLAACKLASLVARRGSLGELATALETYPIRRDSVRVDDREVVMAAVEAAVRERGEAFDAMDGVRIDRDDGWMLIRPSGTEPLVRMTAESRDPARADALFEEAKEIVLESTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWK1</accession>
    <name>A0A3N6MWK1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">dnaK</name>
        <name evidence="7" type="ORF">EA462_07555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89862">
        <property type="protein sequence ID" value="RQG89862"/>
        <property type="gene ID" value="EA462_07555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="649" mass="69811" checksum="4709F73C6BF6927A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWQ4</accession>
    <name>A0A3N6MWQ4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA topoisomerase 1</fullName>
            <ecNumber evidence="11">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">topA</name>
        <name evidence="14" type="ORF">EA462_07885</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="11"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89922">
        <property type="protein sequence ID" value="RQG89922"/>
        <property type="gene ID" value="EA462_07885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="13">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="11">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="11">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RQG89922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="827" mass="91759" checksum="609303D28EF5BF48" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWT0</accession>
    <name>A0A3N6MWT0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89942">
        <property type="protein sequence ID" value="RQG89942"/>
        <property type="gene ID" value="EA462_07995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="145" mass="16972" checksum="4F9444C5E017BEE2" modified="2019-02-13" version="1">MPQIPLHYVDLRTFCYATEDQKRVEQALRTFLPEEFEIDRTESEGHYGDRILVLSTRLEKADDVRYVLSRLADLETYETLIDELDERVTENTELFLRLDKQAAFEGDVRLGEGITFRGKVEAYPAKKEQAVENAEEVLTRLRDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MX88</accession>
    <name>A0A3N6MX88_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_08950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90112">
        <property type="protein sequence ID" value="RQG90112"/>
        <property type="gene ID" value="EA462_08950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017158">
        <property type="entry name" value="Tscrpt-reg_CBS-contain_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037253">
        <property type="entry name" value="HTH_CBS_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="179" mass="19547" checksum="B6F0231F6E418B9A" modified="2019-02-13" version="1">MELPTPADLRQRRTDLGLTQSELAEKADVSQPLIARIEGGDVDPRLSTLRRIVNALEKAESDVVRADDLMNEDVVSIAPEDPVSEAARKMEAEAYSQLAIIQDGIPVGSISQGDLVHLDSDVRDEPVEEHMSESFPTVSKDATLDEISNLLEHYKAVMITEAGETVGIITEADIARRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXK3</accession>
    <name>A0A3N6MXK3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90242">
        <property type="protein sequence ID" value="RQG90242"/>
        <property type="gene ID" value="EA462_09675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="469" mass="51992" checksum="C02B867449E78343" modified="2019-02-13" version="1">MTLSRRSVLTCGGAALVGSSLGGCLSEPNESDPNGSDGTSKGYAAFFALWDWAKHVSGEEMGFENPIEAGEMGHGWEPPADIQREIADSDVFIYLDTAEFSWAQTIASDLEMDYDDVTVIDGMADLENELLPIDRETDDDREPATDYDFDPDSVSIGGFDVYDGQSGEEVAYWHGDHWHGSLPPIPLDGYATVEGVFEDGDERVLPLGEDEQFRIDARIVDGANEDVVEITSRGDRVELHGLETGRTRIVFELVGDGDVVWDTSDDNITTETVEELDESTAPEFYDPHVWVDPVIAQDIVRTIADGLADVDPDNATVYEEHAATYTDRLADVDRQFEELVEEASRDVAVLAGHDSFQYIEHRYEFDIHTPVGISPDAAETESDISETIRVVDEHGIDTILYDPFETPNPDEDVPQMVELLLEGTDAEEYAPLTPAEGTTAEWNEQNWGWVEQMEEINIPSLRRALGARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0A3</accession>
    <name>A0A3N6N0A3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91312">
        <property type="protein sequence ID" value="RQG91312"/>
        <property type="gene ID" value="EA462_04830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="107" mass="11775" checksum="63229CC1FFF8FE82" modified="2019-02-13" version="1">MTVTVRYTCPHCDAVTSVEREPDLADRSVTALSQPGWEYAAPGDDDLESADGIAFVCGEDGPVTDLEEEPVEGCGRPFFLNFVRYERGVELEPNPPTYGGPRFDFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0H8</accession>
    <name>A0A3N6N0H8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91402">
        <property type="protein sequence ID" value="RQG91402"/>
        <property type="gene ID" value="EA462_05370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="60" mass="6530" checksum="D4DE86D42EFD4539" modified="2019-02-13" version="1">MSVNTTMNWVDPVTCPFCGDELASPGAGFVDHIDENGDCERGFDHWRENIAGDLAGEWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0P7</accession>
    <name>A0A3N6N0P7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="7">PEP synthase</shortName>
            <ecNumber evidence="7">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_05835</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 7">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91482">
        <property type="protein sequence ID" value="RQG91482"/>
        <property type="gene ID" value="EA462_05835"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="10">
        <location>
            <begin position="15"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="9">
        <location>
            <begin position="387"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="11">
        <location>
            <begin position="481"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG91482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="780" mass="84381" checksum="65B0B698F1FF7E97" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3W3</accession>
    <name>A0A3N6N3W3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92842">
        <property type="protein sequence ID" value="RQG92842"/>
        <property type="gene ID" value="EA462_01040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="902"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1213" mass="136915" checksum="A1E2D5009A1AE961" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUE8</accession>
    <name>A0A3N6NUE8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AmiS/UreI transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_16735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86780">
        <property type="protein sequence ID" value="RQG86780"/>
        <property type="gene ID" value="EA462_16735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003211">
        <property type="entry name" value="AmiSUreI_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038523">
        <property type="entry name" value="AmiSUreI_transpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02293">
        <property type="entry name" value="AmiS_UreI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="165" mass="17975" checksum="92768B75557122D8" modified="2019-02-13" version="1">MGLLFVGGVLFVNGIWLLGRGSDEDVAVFNFLTGLITFLIVLWWGFGDGSAGTPFDAAGTMLFSFTYLWLGANAYRGVADQRSFGWYCAFVAIVAIPTGYLVLLDGDLGLTALWWVWAALWASFFLLLGLQRDEYTAPVGWFTALVGVVTAVSGYLMAAGFWPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVI4</accession>
    <name>A0A3N6NVI4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87852">
        <property type="protein sequence ID" value="RQG87852"/>
        <property type="gene ID" value="EA462_13385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="88" mass="9952" checksum="19F3A8F0B13BE914" modified="2019-02-13" version="1">MNNSQRGLLVQHLSEAELDQAVEAAQKADETRLVRRLCFIKNLYQGDTREQAGRRVGISRSTTRRWAVAWNDDGIEGLSSRETHPETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWX1</accession>
    <name>A0A3N6NWX1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_11980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89089">
        <property type="protein sequence ID" value="RQG89089"/>
        <property type="gene ID" value="EA462_11980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="83"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG89089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="290" mass="32867" checksum="6A600FB568E7C6FB" modified="2019-02-13" version="1">MGQGTDAEFGLVELEDGETPGDEWEEIDVSDTEADRIARKRDRKFEQFEERIKDADQFKVEQSVFDDATLAALYKLVQDGHVEAFGGPLSTGKEANVYQALAGDHEVAVKVYRINSSSFRQMRDYLEGDPRFEGLGGNKKDVVLAWTKKELANLERAKRAGVRVPEPIATERNVLVMEYIGNEDGRAKRLGEVHIENPRTAYEVMREYMRRLYAAGIIHGDLSEYNVVFHEGQLVVIDLGQAVTVHHPNSREFLERDCENVSSYFARQGVETDPDELLEFVTNPEPDPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYG8</accession>
    <name>A0A3N6NYG8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Geranylgeranyl reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89869">
        <property type="protein sequence ID" value="RQG89869"/>
        <property type="gene ID" value="EA462_07595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="458" mass="49372" checksum="2492EED3305F3908" modified="2019-02-13" version="1">MTSSTESYEMVVVGGGTAGCFAAATAARDGLEVALLERKTADEAGKIACGDGIKGKSSFPDVVDRDRLKSESFTNREISRGIFENPRTGESIEIPFGQTGAVVDRHAYGQVLLDETERAGAEIHYDTVVNDVVQPNGRVSGVTAVRDGEPLEYEADVVVDGAGSLSVLQDKADLSSSTFDTNVNYSQFCSAYREVLEVPEPVEWDDALVFKPTEELGYLWYFPRSSTEINAGLGFQMSQKPMALVDVLKDDIASRPEFSDASVKNKLGAALPTRRPYDSAVHPGYLAVGDAAGHVNPCTGGGIPGAAKAGHWAARVAADAIADGDVSEAALWEYNERVQTDFGKRFAAMDLYNIFGTAHDLDELVALITALPGQQLVDAIGKTGTADMGLGLKLRTLLKTVGHWDVLYELYRVQNAAGSLKDVYDGYPDDPSRFSAWQRERDAVLDRVYDVTGADPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZF8</accession>
    <name>A0A3N6NZF8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90339">
        <property type="protein sequence ID" value="RQG90339"/>
        <property type="gene ID" value="EA462_10215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="77" mass="8129" checksum="08CF73C8C44E02F1" modified="2019-02-13" version="1">MNSRDGPADAGRTPRDLVCGRCGDSVPAARVIHLSSEPCPELTGHYESVTKSFCSDCVAAVGMLEFTAAARSRVESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1H1</accession>
    <name>A0A3N6P1H1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl14</name>
        <name evidence="5" type="ORF">EA462_05075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91349">
        <property type="protein sequence ID" value="RQG91349"/>
        <property type="gene ID" value="EA462_05075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019971">
        <property type="entry name" value="Ribosomal_L14P_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03673">
        <property type="entry name" value="uL14_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="132" mass="14319" checksum="44489AA767D9E12E" modified="2019-02-13" version="1">MEAMKADVTQGLKKGSLITCADNTGARELKVISVSGYHGTKNRQPKAGLGDKVTVSVTKGTPEMRRQVLEAVVVRQRKSIRRPDGTRLKFEDNAAVIIDENEEPRGTEIKGPIAREVAERFGAIASTATMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1I6</accession>
    <name>A0A3N6P1I6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91369">
        <property type="protein sequence ID" value="RQG91369"/>
        <property type="gene ID" value="EA462_05175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="157" mass="17507" checksum="50572FF9B51CC287" modified="2019-02-13" version="1">MTRFDATEPNDRRKLYVDAITAHRERGSAFLTLEVDDSELGGDELGTEETDHVDGDRKRNSRETTGPDPELGTPWIQFSDGTINLDCTDDELEELKAVLGEFPAFKISELTRPDDAPGTNAHVSAKADPNRIGQFLDAVFRRVYGLPAEFRVWVVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P264</accession>
    <name>A0A3N6P264_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89225">
        <property type="protein sequence ID" value="RQG89225"/>
        <property type="gene ID" value="EA462_12735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="410" mass="47679" checksum="12D8FD622E56D102" modified="2019-02-13" version="1">MDQRKTEHRSRDERGRTAERFVVDCVRAAIGNRRGRFDWVDADLEWDRVVALATKHGVSSLIVSAIETHSVQNVPDSHLQTLENRTKYVSQRNLRLFQEVATLSAAFQNEGISAIPYRGPVAGEVIFGSVGRREFGDLDFLVSRESIPDLRSVLLERGYDHQYVLETTGDLTENQRWAYARFSRDYAFVHRTEPFEVELHWRVVSRRFPSTIDLGTVWERRSTLPVAGTDVPVLGHEDRLLMLCVHGTRHRWERLMWLCDVCAYINTQSFDWDTVLERARRHSRERMLYLGLAVADELLGVGLPETVRRAIDRDPVIDSLTSHVRNRLFDEATYWHLDTKRYQARTLDRRRDRVAFWIKGAIEPDRGEIELLSLPRPLVPLYSLVRCFRIGRATLNRLLTPTKCGEKRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3G5</accession>
    <name>A0A3N6P3G5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_07350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89825">
        <property type="protein sequence ID" value="RQG89825"/>
        <property type="gene ID" value="EA462_07350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="302" mass="34053" checksum="1D4014554AB2E088" modified="2019-02-13" version="1">MAENYYEVLEIEPDATRTDIEDAYRRRVLETHPDHNDDPDAIDEFQRVSTAKSILTDGDERARYDRLGHDAYVRLGRYAGPTSSSESPGQRTDDRRSSESAGMSSDRRTGSKGTHRRHRQQRSNRRTNRQRNHRQHRQQRTATGRSAESNRSFDPGASSETTEDTNSEASNGETNSAFRYTVQDWDEDVDLEWEGRSIDHSTAVTVTCLWILYPVFVYSSLTPMVSPILNGLLLVCTLGVIGYLLTMPRVAMLVFGSLSVLFPLGVGQLQLIEPLSLHGGVSVAFVWIPFGYAVAVWWALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3J4</accession>
    <name>A0A3N6P3J4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF790 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89865">
        <property type="protein sequence ID" value="RQG89865"/>
        <property type="gene ID" value="EA462_07570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008508">
        <property type="entry name" value="DUF790"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39640">
        <property type="entry name" value="PTHR39640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05626">
        <property type="entry name" value="DUF790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019435">
        <property type="entry name" value="UCP019435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="508" mass="56468" checksum="0E511409A902837A" modified="2019-02-13" version="1">MLTKDLLRISRAGGGYHPQFAAREHRPLAARVVGTYQGHVDETRGELEDALTDLERDADDFKLVRGFAALLERDATFETEAAIEPERARRAAFEAAEAVDVVTADERAMALVRAGESFGVSADDLERSFYADLDERQVLTEVDPRWDPDGLLAQYNLSLAQTALFDATELRVRSSDPNGLVSAVKRLRLMYEIRKRTENETSGDASNREVVVTGPTHLFRSTRRYGTRFARLLRTVASANAWHLEATIDDRGTERLLELSDDDPVGVPTADPVADVSFDSGIEADFAARFSDLDLEWDLVREPEPLATGTRVMIPDFSFEYEHASFRVFFEIMGFWTPEYVEKKLKQLEGLEEVELVVAVDESLGVGQEIAARDFRAIPYSGSVRIKDVVDVLREYERQLVAESAASLPGEIVPDDDVISLEKLANRHGVSVDALADVTVPEHDRIGRTLIRPTVIDALEEALDVGMDLADAESRLEEYGVSDSSAMLSRLGYRVEWDGLAGGTIVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3S9</accession>
    <name>A0A3N6P3S9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative adenylate kinase</fullName>
            <shortName evidence="2">AK</shortName>
            <ecNumber evidence="2">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89995">
        <property type="protein sequence ID" value="RQG89995"/>
        <property type="gene ID" value="EA462_08285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="PTHR12595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="2">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="2">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="169" mass="18693" checksum="DAACBD2A7423D6B0" modified="2019-02-13" version="1">MRIAVTGTPGTGKTTATDLLESRLDIVHLNEILESEELYTEVDAERESKVADLNGLSDWLDGRDDAMIESHLAHRFEVDRVVVLRCEPESLEDRLLERGESRAKARENAESEALDVILAEAVEEHGLESVYEVDTTDLEPETVADELEAVVAGDREPGAGEVEFVGYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P491</accession>
    <name>A0A3N6P491_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1616 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90185">
        <property type="protein sequence ID" value="RQG90185"/>
        <property type="gene ID" value="EA462_09355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011674">
        <property type="entry name" value="DUF1616"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07760">
        <property type="entry name" value="DUF1616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1616" evidence="2">
        <location>
            <begin position="33"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="346" mass="37192" checksum="EAD50A7808096B6A" modified="2019-02-13" version="1">MKDRSTRTFQPFTTVRQGSKHLAARLPTDLAGVVGFVALAVVLLAVIDVGSILARAAIGFPLLFFVPGYVTVAALFPRGGPDHESGSPVSIDRCGVSPLERVALAFGLSVAILPLLGLVIAVAWGFSAGVVVATVAGYATVVAWIGAIRRLRVPTSERYRFSLVPTVETARARIFDTRSSFHAAVNVVLVASLIVALTTVGYALVAPQQGEQYTGLEILTENDAGELVTEHPDEVVASEPFELTIGVENREGQDAEYTVVVQEQWISDDTVIERNELQRIDFAVSDGDTAHGDRDVTPVAEGGDVRIAVLLYEGDDVPETPTTENAYRYGYFWTEIVDEIDASSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4H1</accession>
    <name>A0A3N6P4H1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">coaBC</name>
        <name evidence="6" type="ORF">EA462_01085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92849">
        <property type="protein sequence ID" value="RQG92849"/>
        <property type="gene ID" value="EA462_01085"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="5">
        <location>
            <begin position="179"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="184"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="390" mass="41202" checksum="2641237C45B6C18F" modified="2019-02-13" version="1">MLEGVNVALGVTGSIAAVKTVELAHELRRRGADVRGVMTDSARGIVHPWAIEFATDDDVVTEITGSVEHVDLCGYDGWADVFLVAPATANTVGKIAGAVDDTPVTTCATTALGADTPVVIAPAMHEPMYDHPGVLEAIDTVSSWGVEFVDPRIEEGKAKIAREEAIVCDVARAASDRPLEGNHVVVTSGATSESIDPVRVLTNRSSGRMGRAVARACYVRGADVTLVHDGDEVPYANVRAVESAAEMLAATRDACADADALVSAAAIGDYTVEASAEKIRSGQDLTLELEPTPKLIDEIRDERPAVPIVGFKAETSGDERSMLERARETLERADLAFVVANDASVMGSDRTRTLLVHENDAARYEGTKAGLGDEIADSIAAILTDDMPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4Y2</accession>
    <name>A0A3N6P4Y2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93079">
        <property type="protein sequence ID" value="RQG93079"/>
        <property type="gene ID" value="EA462_02415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="63" mass="7317" checksum="27ECCCC3EEDD74EC" modified="2019-02-13" version="1">MATVSPYLAFDRLTVLDFPVPFYFDKEISSAFSMFDIYIGLMTASIVNFVLEIYLIRVIHFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P5D1</accession>
    <name>A0A3N6P5D1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93309">
        <property type="protein sequence ID" value="RQG93309"/>
        <property type="gene ID" value="EA462_02430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="499" mass="56802" checksum="CC8F91BCBD216CB1" modified="2019-02-13" version="1">MYGLTRDQYNRQHADWRKTGYQVNGDYNSIATKLQDECEAEDQVLYPIHIESDELQRVGPKVLTDWFREFVEDHLEVPFRSCTQYFSGSRSIHIHVPRFVSGERQRERLKQQAEKFCEDTGAKLDCCIYGRKRLFRLPGVEHEKTGVPKVEFDGEWDDSQMCKLYQKATPDVPESYEAVLRHVFVKDSLTIGTVSQAAYTPQDLFQVLDSDKTILEFGCDKKSIETPLIELQEPPNEASTSEMKQWLMCNAKEFSPYALADGNFRSVAALKIKGTPFARKEVTAGNSSRPVHALIPAYFYGAQGCAGEKFTKADEHAPLQLSKGKGKDYDKWTSSKFVPGDNIVIIGGKSRSSKIHSVKSYQAIAVGNILTGENGSRDKALEYLENEGFDIGSAGRTEPRSLTRELAKSRGYSESGPRSMELTKAQKFKQQAERDGIQSLSPEERFQVACRLLLRGWQPAWDWFKEQFGSEFKPDVTRTYFTSIVNRWPEYDHVQIPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P5X5</accession>
    <name>A0A3N6P5X5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91085">
        <property type="protein sequence ID" value="RQG91085"/>
        <property type="gene ID" value="EA462_03530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="93" mass="10166" checksum="8380221B805DCD16" modified="2019-02-13" version="1">MDSRNKLTSVPSLGSLRKRVRTTLSGSRPRTNRSTDADLECDSDGKSPSGSPDSPGNLFHCSTCRTVYIAHDKRVCSECDEDLEQVSSTLSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA63</accession>
    <name>A0A3N6PA63_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93235">
        <property type="protein sequence ID" value="RQG93235"/>
        <property type="gene ID" value="EA462_03305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="442" mass="47959" checksum="50B812FC31E70FD0" modified="2019-02-13" version="1">MAREQVTVEADETSPLDTFQQFFSLKRDVLVLSLAMFAFSLGFQMTNRFLSEYLIFLGASGLVVGIWGSFGNVIGAVYPYYGGVISDRVGSRYALTVFGFLSSIGFGIWLAAAFIDPIDLGVLTIEPWVWVFVGLLLAQCWKSFGIGGHYAIVKQATEPDRLARGFASTETFRRTAFLLAPLIVAVLVADEFIPGFLWVLVIGIIFAVLGTFVQHVMYESKQDSVGSEFEGFGQILDDLRALPEPLQPLLVADTFVRFANGMVYVFFILVITQMMEIGWMVNVPAVGAIDLAPAAFFGVLTGIEMLVALLTMAPAAKLAERTGLKPVVGFGFFVYAAFPIVLIFAPEDVWVLIALFAFSGLRFAGLPAHKALIVGPAERGAGGRVTGSYYFVRGAIVIPSGLLGGILWDYATPETAFTAASIIGMVGVVYFAIYGKEFDAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHV3</accession>
    <name>A0A3N6LHV3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86215">
        <property type="protein sequence ID" value="RQG86215"/>
        <property type="gene ID" value="EA462_17220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="148" mass="15445" checksum="B6737995860E51F9" modified="2019-02-13" version="1">MIGANVVVAGCGLVIAVVVGLVVHEWLHALVLRLANIEYTISYAPDRTDGILAMLASCPWAVVDPHPTGREPPWVFRLAALAPLGLAAPVFAVAATGGLTAGSPLETAVTIGLLACSLPSPQDFSVAFYAHRMLAEDTNSSTRRSRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI71</accession>
    <name>A0A3N6LI71_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(+)/NADH kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87004">
        <property type="protein sequence ID" value="RQG87004"/>
        <property type="gene ID" value="EA462_15275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="270" mass="27887" checksum="78C614370867556A" modified="2019-02-13" version="1">MSRTAWAPESDPLIGLVTERPPANGESPGSAASIASGTDRSIVDVESSIADLGAAAVSGNLEDVLADEPSLLVTPGERALTEAASRARATPILPVGTVPGVPTIDRTSVEGALEAALDGGAVLSEQPLLTAETPRGRRDRGVFDVTLVTEEPAQISEYGVRSRDESIAQFRADGVVAATAAGSHGYASTVDGPLLSRAIDALVVVPIAPFVTRTRQWVLPDDELTLSVERDEDPVVLCVDDRSVERIPAGESVSVSASETSAVLTVPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIX4</accession>
    <name>A0A3N6LIX4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87946">
        <property type="protein sequence ID" value="RQG87946"/>
        <property type="gene ID" value="EA462_13875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="1">
        <location>
            <begin position="15"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="485" mass="51845" checksum="A988014CFC510B0A" modified="2019-02-13" version="1">MTYDGPTALYIGGNWVPAADDETIETVDPATEDAYASVACAGESDIDDAVAAAEEAADRDAEWRSIGPSERGQYLSAMADEIEEMKDEIVLVESHDNGKTPFEATLDVDMVIDTFRYYAGFTDKIHGETIPVPGSRVDYTRREPIGVTGHISPWNYPFQLAGRSVAPALACGNSVVLKPSSTTPLSALYYAKAADAVGLPPGVLNVVPGSGRNAGTALATHEDVDHVAFTGSTGVGKSIMEYAAEDVSGVTLELGGKGPNIVFEDADLEAAAKGCHYGIFMNAGQMCWAGSRLLVHESVHDEVVDRVVERAQATPLGSGIDDDGRMGPLVNESHRDDVLEYIETGVSEGATIACGGGVPEDRSTGYYVEPTVFTDVTNEMTIARAEIFGPVLSVIPFSDRQEALDIANDSLYGLMAGVWTKNIDVAHDTAERLEYGMVSVNEYPVTFPQTPFGGYKESGFGREQGAEAIREYTQVKNVNINVDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ31</accession>
    <name>A0A3N6LJ31_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88056">
        <property type="protein sequence ID" value="RQG88056"/>
        <property type="gene ID" value="EA462_14495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="393" mass="42765" checksum="0B1B339A84E62C7B" modified="2019-02-13" version="1">MLSHYTVLEVGDYVAVPYAGKLLADCDAEVIKVEPPDGDSARRVAPFVSGDGRSESAVFGYLNTSKRSLTLAESSDRAPELLEELIETLGVDLVVEDRLDAYGLDARELQTRHDGLTVVSVTGFGSDGPFADYSAPEIVAMAESGQMNKMGYPGEPPLRPRVKSADYWAGQHAAIGGLASLLSRDLQDDSGQHVDVAARDVAITYMEGFVAGFSWSGACTERTGLGYPDQDGQPGLPALYETADGYISAAVSDARWGTFCEDVLERPELTSDERFSTPEARLENLPELRDVVESYTGEQDKWALFEEFQANGIPCGIVQTPTELLEFDHLHDREFWVDLELPNGETVTSPGFPFRVDGSPVPMGSPPALGEDNELYDELERDRTRLAASGVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJA2</accession>
    <name>A0A3N6LJA2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87971">
        <property type="protein sequence ID" value="RQG87971"/>
        <property type="gene ID" value="EA462_14025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="199" mass="21864" checksum="59AE648B3A3CDB22" modified="2019-02-13" version="1">MSRTSNQADGDVVRDFLSVADLLEEPRLARLYTNLAREDGAAVQDVMDDIDLAQGTAYSYVNRLVDAGVVEVTHDEQPRRYAAREIDLTVTTTAGDREYTITPALIDAVGRRKMDADIDTYIDRHGVSGLATALTYAVARERGEVTHRLMADDLTISPLAAEIILQALRPVVHEYYEIEESGASLDALHADDRDAADDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJG0</accession>
    <name>A0A3N6LJG0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88071">
        <property type="protein sequence ID" value="RQG88071"/>
        <property type="gene ID" value="EA462_14580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="IclR-ED" evidence="3">
        <location>
            <begin position="74"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="271" mass="30788" checksum="D6A6C66A1754A466" modified="2019-02-13" version="1">MSPNRNPSDSSRVLQTADTTFEIINVIKSRDGAKATEIAEHLDLSRSAVYNHLTTLIENEWIIRTENSYQLSLKFLMLGVYVRNHNRLFSVGKSEVQKLAQETGETAHLATEQQGYQINLLKETGELAVGDQYHTQKLQQTNYHHDTATGKAMLAFLPEERVETILDKQGLPSKTSNTITDRDVFLEELHEIRERGYSYNDEEEIEGLRAVGAPITDQHGNVLGSVSVSGPTSRLKNDRYHEELPEKVMSTANIIELNLNMERRIDRPNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJP8</accession>
    <name>A0A3N6LJP8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoserine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88953">
        <property type="protein sequence ID" value="RQG88953"/>
        <property type="gene ID" value="EA462_11210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="293" mass="34710" checksum="B7A40FA767371D84" modified="2019-02-13" version="1">MVDESKNIELTEDDLENKSKGQLIKMAGQLRDRRNELNQMASSRASSRDDLNAKTREKVDEAQEHREKRDELNEQVQEHKESRNELNAEANELFDKVEKLKSDMELDEGKDLEELEDEIEQLEFKQQTEVLSSEEEKELIEKIEGKREEYEERKQKLDQNSDLEGLVEEAEEVRSEASKHHQKVTELADKAQEHHNQMIEAYREADDIRDEADDMHEQFVEAQEAADQHHEDFVRVQKRLRELDKEEEKERKSARDKKKEEAKEEAEEIYQKFKEGETLDTEDLMKLQKTGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJW8</accession>
    <name>A0A3N6LJW8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_10740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88868">
        <property type="protein sequence ID" value="RQG88868"/>
        <property type="gene ID" value="EA462_10740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG88868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="28082" checksum="9FF7235591CB38A6" modified="2019-02-13" version="1">MTLEAINVHHGYGNETVFEGVSLTVTPGEVVGIIGPSGVGKSTLLRLLALFDAPNQGSISYENEDVWQVSEQQRLEYRRQIGMVFQEASLFDASARRNAEYGLRVRQSWTDRLRHELSSLVGKTNGTGDAIEALDTVGLREKVDQDASSLSGGEAQRVAFARALAYEPDILLLDEPTSDLDPRNTAVIEDAVLEAKKRGIGVVIATHDMHQAERIADRVAVLLENDIIEVGDTETVFENPTDERTQKFIDGELIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKH1</accession>
    <name>A0A3N6LKH1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89138">
        <property type="protein sequence ID" value="RQG89138"/>
        <property type="gene ID" value="EA462_12260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="86" mass="8954" checksum="A0A1B5E4A69BC008" modified="2019-02-13" version="1">MLDRERVIEIIVAVSAVLVMLGVMFYIGVTYGGENSVLSPDGAEMLVGAIVGFILLLTAVGIGLAFVLNEPGDGLEDEDTEAKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKS5</accession>
    <name>A0A3N6LKS5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89288">
        <property type="protein sequence ID" value="RQG89288"/>
        <property type="gene ID" value="EA462_11995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="81" mass="8509" checksum="75375C390375D41E" modified="2019-02-13" version="1">MARDTCDGCGRAVSVAGGMANVWTFGKNDGSAGTAMTLEFDDGTDHLLCYPCLAALPDEPSVADVDRLESVDGETSRLREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LL62</accession>
    <name>A0A3N6LL62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03557 family F420-dependent LLM class oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87790">
        <property type="protein sequence ID" value="RQG87790"/>
        <property type="gene ID" value="EA462_13025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="336" mass="37991" checksum="D5A421978554C46D" modified="2019-02-13" version="1">MVSIDYMAHQEQYDPNELLEYSSLAEDAGYDFVWTSDHFHPWFHTDAEAGFAWSWLGAACERLDIPIGTCVSPATGHYHPGIIAQAFATLQSMHDERVVLGLSTGEAMNETPLGFDWPEYPERRDRLEESLRIIRALWGDEQWVDSELIGEDGFVTYDGDRFELNEAKLYTNPERSPEIHIAANGPSTARLAARYADGFITVKKGEEYTDRLYPAIRRYAEEEGNDPDAIETTLLVIASYDPDYEAALEATRPWWATTQNVFDRAMANPMRIEREGEKATREQVEEKFLIADEPETIAAQLEEYAEMGFDRIAIGNTSPDPAALFDVMGDDVIPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LL96</accession>
    <name>A0A3N6LL96_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4147 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87850">
        <property type="protein sequence ID" value="RQG87850"/>
        <property type="gene ID" value="EA462_13370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="19"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="341"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="450" mass="46278" checksum="DA1C8699F28EE2E6" modified="2019-02-13" version="1">MADIENRSVLSRTTGHETALACLEAGIEAAHPDNLVAERLSLEGDELTIDGFGTGRTVFDLERYDDVVLVGGGNAASQLASAVEDLLGERIGGGAVVTDDPVGTDRIDVFVGDHPVPSRRGVRNADRVLELAQSATEDDLVIACLTGGGSALLPAPVDSISLSELQTTTDRLLASGATIHEINAVRKHCSLIKGGQLARGASPATVVGLVVSDVVGDDPSVVASGPTVPDSTTYEDAIAVFERYDLDVPDAVWTHLRNGLDGSVPETPGPDDPLFERVSTHVLGNNRTALDAAAEAAAARGYEPVVLSSRVRGEAREAALTHVAIAEECRTTGDPVAPPAVFLSGGETTVTLGQEYGTGGPNQEFVLSAAVELELDGVVVAAVDTDGIDGATDAAGAIADASSVDTVEGRTALESNDSTTALSQAGSIVRTGQTGTNVNDLRVFVVDSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM17</accession>
    <name>A0A3N6LM17_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Triosephosphate isomerase</fullName>
            <shortName evidence="2">TIM</shortName>
            <shortName evidence="2">TPI</shortName>
            <ecNumber evidence="2 3">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">tpiA</name>
        <name evidence="4" type="ORF">EA462_08300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="2 3"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89998">
        <property type="protein sequence ID" value="RQG89998"/>
        <property type="gene ID" value="EA462_08300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_A">
        <property type="entry name" value="TIM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022891">
        <property type="entry name" value="Triosephosphate_isomerase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="6"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="214" mass="21633" checksum="4E4E0B095E1E7B9B" modified="2019-02-13" version="1">MFILVNLKTYPCDPVAVAEAVRDVDESTDARIGVAPQATHLERVAETGAETWAQHVDPIEYGSNTGHTLAESVADAGAVGTLINHSEHRLKLADIDGAVRAASRTDLETVVCANNPAQVGAAAALGPDAVAVEPPELIGTGTPVSQADPEVVEGAVGAAASVDIDVSVLCGAGISTGDDVVSARDLGSEGVLLASGVAKADDPRTALEDLVDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM42</accession>
    <name>A0A3N6LM42_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86141">
        <property type="protein sequence ID" value="RQG86141"/>
        <property type="gene ID" value="EA462_16855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="140" mass="15492" checksum="469DFEFBDB0366F9" modified="2019-02-13" version="1">MPTEDADELRRILGYDRVAVVGASTSYEKAAHIVPAYLQRHGYELRPVNPNADEIFGECAFDSLADVTEPVDVVEIFRPSEDVPEIIAQTLAREDVKAIWMQSGIQNDEAALEAETAGLDVVQDRCMKVEHGQLIRNPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM77</accession>
    <name>A0A3N6LM77_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PGF-CTERM sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EA462_10795</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
            <location evidence="2">S-layer</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the halobacterial S-layer protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88877">
        <property type="protein sequence ID" value="RQG88877"/>
        <property type="gene ID" value="EA462_10795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030115">
        <property type="term" value="C:S-layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026371">
        <property type="entry name" value="PGF_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026452">
        <property type="entry name" value="Surf_glycop_sig_pep"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04207">
        <property type="entry name" value="halo_sig_pep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04126">
        <property type="entry name" value="PGF_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0701">S-layer</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="758"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="786"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG88877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="873" mass="95622" checksum="DFC7FC08474AC2F8" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMK6</accession>
    <name>A0A3N6LMK6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagella cluster protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86775">
        <property type="protein sequence ID" value="RQG86775"/>
        <property type="gene ID" value="EA462_16710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="76" mass="8897" checksum="C5B0AC718CA1D424" modified="2019-02-13" version="1">METDFDVHDHRHRMKLLRDDGATAAYDNRTQLQCPVCSNPFDRLLLIKTETISFPKNDGIPFCLVHRDDDIALFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMT0</accession>
    <name>A0A3N6LMT0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uroporphyrinogen-III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89157">
        <property type="protein sequence ID" value="RQG89157"/>
        <property type="gene ID" value="EA462_12370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="2">
        <location>
            <begin position="20"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="267" mass="28109" checksum="546C1EBE20F2EB71" modified="2019-02-13" version="1">MSDQPTVAVFRPDDERLAEASALLESLGADPIVDPMLAVEPTDETPRTDAEYTIFTSKTGAELVADAGWERGETTVCAIGTPTASALERVGYAVDLVPEEFTSSGLVAALDGSVNPRIERDERESDAERRSANTPRETVEGARVEVARSDHGSDVLLEGLEAAGAYVHETVLYRLVRPEGSGESAERAAGGGLDAACFTSSLTVDHFLESAADRGIRDEALSGLANATVGVIGDPTRETAESQGIDVDVVAEEATFDALARETLEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMW7</accession>
    <name>A0A3N6LMW7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_12800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89237">
        <property type="protein sequence ID" value="RQG89237"/>
        <property type="gene ID" value="EA462_12800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="319" mass="34789" checksum="A9B86F4187C9F4BE" modified="2019-02-13" version="1">MSTNDFDLTDESITSERASDSHASGLETEDRSPGSDRIELAGRIERLETENDRLRREYVRLKRTQHRTRALGLVAIGLIAVGGAVVFSDVRSILVALGATGLFGAVLIYTLAPETVVSADVGERIYSALASNHRAMVGSLGLGDERLYVPEPNRSEPPAEHAVPRCRLFVPRYQEYAVPESDDGPIVTDEDARGLVLEPTGRRLFSEFERGLTTELESDPERLSEQLSDALVEGFELARSVQPDVDSRRVTFAITDSAFGNVDRFDHPIASFLAAGLAIGLEQPVSLEVTDAGERTDWLVTCRWGDDRGGDGPSTDESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNR7</accession>
    <name>A0A3N6LNR7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87827">
        <property type="protein sequence ID" value="RQG87827"/>
        <property type="gene ID" value="EA462_13235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="248" mass="27433" checksum="F4D8D50CFCB42DA8" modified="2019-02-13" version="1">MTLLELDDVHSYYGHSHILRGVSMEINDGEVVSLLGRNGAGKTTTLRSIAGATPPEVNSGRIRFDGTDITDMNTEDVIMSGIGLVPEERRLFTDLTVEENLLLSQISQSTWNTIRRKVSPRETNGKSLDELYELFPRLEERREQRAGTLSGGEQQMLSIARTLRLPNVELLMLDEPSEGLAPQIVEAVMNAIETIAAEGTTVLLIEQNVQAALELADRGYVLDMGDIVYEGSAAELRNEDDLDQYLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNX1</accession>
    <name>A0A3N6LNX1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_03615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91098">
        <property type="protein sequence ID" value="RQG91098"/>
        <property type="gene ID" value="EA462_03615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="389" mass="42102" checksum="06B00E22CA6F8BC5" modified="2019-02-13" version="1">MTNNVVVLGAGYAGAGAINTLQSELGGNARLTWIADVDYHLVLHESHRVIRDPTVRSDITFAVDQIADPSTRFIQDEVTGLDVDEQAVELADGDDVDYDYVLVALGTKTAYYGIPGLEEHSRTLKSLDDALEIHDAVKSASQDATRGEPAQVLIGGAGLSGIQTAGEIAEFRDEHRAPIEIHLIEALDEIFPGNDPEIQQALRDLLEDAGVRIHTDDPITEATADHIEFDEGDPLEHDVLVWTGGITGRDALDDADLEKEHNRVNTEANFQTSDERVFAIGDSAIIDQGDQPAPPTAQAAWQAADVVGENIARAIENRPLKTWEYEDKGTVVSVGDEAVAHGVKPAFGVSLPVDTFGGFPAKNLKKMIAARWIADITSWGESRRSWSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNZ0</accession>
    <name>A0A3N6LNZ0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin-like protein CetZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cetZ</name>
        <name evidence="7" type="ORF">EA462_07090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in cell shape control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CetZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89777">
        <property type="protein sequence ID" value="RQG89777"/>
        <property type="gene ID" value="EA462_07090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01946">
        <property type="entry name" value="CetZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032907">
        <property type="entry name" value="CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="2"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="10"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="386" mass="41094" checksum="F5CCC13A0C86B8F1" modified="2019-02-13" version="1">MKLALIGFGQAGGKIVDEFLAYDERVGDGFVQTAIAVNSATTDLHGLEHIPQDNRVLIGQARVKGHGVGADNELGAEVTEEDIDEVQGAIDKIPIHEIDAFLIVAGMGGGTGSGGAPVLATHLKRIYTQPVYGLGILPATDEGGIYTLNAARSFQTFVREVDNLLVFDNDVWRSAGETVASGYDRINQEIVERFGLLFAAGEVNQGDHVAESVVDSSEIINTLDDGVSTIGYARETVDSSSDGLLSTFRDTDEFDEGAATNRMTSLVRKAALGRLTLPCDVASADRGLVVTTGPPEHLNRKGVERGRQWLEDETGSMEIRGGDYPIPDSNEVGAIVLLSGVTDVPRVNQLQQVAIETQDRTNALQAKADEDLASLVDTGGELDALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPA3</accession>
    <name>A0A3N6LPA3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88107">
        <property type="protein sequence ID" value="RQG88107"/>
        <property type="gene ID" value="EA462_14445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="213"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="413" mass="44546" checksum="B51FE90030C9A2ED" modified="2019-02-13" version="1">MAIDHERLRSDIEANARHGAIETDTGRGRTVLTGSDADKHVRERFIDRLEDAGLDHRIDRVGNIVGRWVPEGASEETPPVALGSHLDSVPSGGIFDGPLGVYSALEAVRSIQESDETPSRPLEVVCFTEEEGSQFGIGTLGSRVMTGRMSVESALELTNDGGETLEQRLERIGFAGTGDIDPATWHAWFEVHVEQDTRLESAGVPIGTVDSISGITNCAVTVTGEANHAGATSMDERRDALVAAAEFVVDVERIAEEIAAEHPSAVATVGRHDVEPNVRNIVPGGVTMQMDIRATESDVIDTLVDRYADRLDRLERRRPVETSIDRYRDTPPIGLSERCIDAINRGADRQGVDSMDLYSAAIHDTANVSTVTDAGMLFAPSRDGISHSPQEWTEWEDCATSAGVLAAAALEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPL2</accession>
    <name>A0A3N6LPL2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose utilization protein ThuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91428">
        <property type="protein sequence ID" value="RQG91428"/>
        <property type="gene ID" value="EA462_05505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009381">
        <property type="entry name" value="Trehalose_catabolism_ThuA_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030013">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="231" mass="26269" checksum="920935450BBCF002" modified="2019-02-13" version="1">MADVTIWNEFRHEREDDDAAAVYPDGIHETIAEGLGDAHEIHTATLDEPDHGLDEGRLERTDVLIWWGHTAHDEVATDIVDRVHARVLDGMGLIVLHSAHYSRVFKRLMGTTCSLQWREDGRAERLWVVDPGHPIVDGLDESIELPETEMYGEPFDVPEPDRLVFVSWFEGGEVFRSGCCYRRGNGRIFYFRPGHETYPIFENDAVRRVLKNAVDWAASPGGSPRSFGERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPS3</accession>
    <name>A0A3N6LPS3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91503">
        <property type="protein sequence ID" value="RQG91503"/>
        <property type="gene ID" value="EA462_05950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014651">
        <property type="entry name" value="UCP036983_2CBS_MJ1404"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036983">
        <property type="entry name" value="UCP_2CBS_MJ1404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="133"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="211"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="385" mass="42703" checksum="7B632AA2FA86D60A" modified="2019-02-13" version="1">MNIADIATQDYIEVDVGTRMGKVRSTFENGNPKGIIVTNDGEYEGVISEREVLQSHVEDDAKVAALTKPSRSAPAPKIDRHEDVRETARVLVESNAKVAPVFEHDELWGVISDDAILEAVLENLDTLTVEDIYTDAPVTLTEDDGIGKAINYLREHGISRLPVLNDSGFLTGVVTTHDIADFVIRENHTTTTGDRVGDSDRLLDVPIYDIMTSPVQTTTLDTTAKEAVETMLELDYAGLMVTPEDDDRVVSGVITKTDVLRALTFTEEEYMDVQITNVSLLDTISRESIVQSIEDVSDKYADMQVMHAHVRFTEHKEKLRGTPLVQCQIRLRTNKGQVAGTGEGYGAENAFRVALDKLERNVLEVKGITADEEYRGQLLRKLNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPS4</accession>
    <name>A0A3N6LPS4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90187">
        <property type="protein sequence ID" value="RQG90187"/>
        <property type="gene ID" value="EA462_09370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="135" mass="14370" checksum="78D73CB227A747C1" modified="2019-02-13" version="1">MSSTERRSLLYVLLAAAVLLTIGVHVSLVPRYFPDDPFMAALSLGVGWLSYTIVFYAVGRVRSHPGILPSMRTADIGAALFLVSLLLALALDSLGFPPTLVIEAYALPAVGIYVGLALIGWSVGRRTNAINAVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPZ4</accession>
    <name>A0A3N6LPZ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91613">
        <property type="protein sequence ID" value="RQG91613"/>
        <property type="gene ID" value="EA462_06590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="164" mass="17967" checksum="C4126B091EFACC53" modified="2019-02-13" version="1">MRIQFQHSIRAVDVVATTTGTAVYSIEDWHPLGLKPRSPLAVSGDPHLAALVGIVALALLGGVLVIRNRLENRSSLSTAGELPREEIVTDRERIRTLLSENGGRMKQSNIVDSVDWSKAKVSRLLAELEEDDQVTKLRLGRENLVCLPGNEPSATRSPEHSSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ56</accession>
    <name>A0A3N6LQ56_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89064">
        <property type="protein sequence ID" value="RQG89064"/>
        <property type="gene ID" value="EA462_11845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="191" mass="20379" checksum="466F93377749947A" modified="2019-02-13" version="1">MTGVGDPNVESVDTKLEAVDPVEIVDATEGVSIQSSGVIFQQVDVAEKYLGSCGTIGYDDHMYYHVAMELGDYKFDDLGDAIAYGVVCDALFILVGSKSKTIKQLLKKISDHPLIRTIPDSICAFISGTVLDGIFSGNDGTVAFWDRESGGTVSTSQLVFGGSGEYDPDPEDVIDKGPVEEFTGVHTEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRS4</accession>
    <name>A0A3N6LRS4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91147">
        <property type="protein sequence ID" value="RQG91147"/>
        <property type="gene ID" value="EA462_03895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="62" mass="6510" checksum="F8A22E8197906D1F" modified="2019-02-13" version="1">MASTGDEGDDSGEPTASSEQATADSRASGPVCPHCQAPLYNRHCKYVCPQHGVVIDCSDPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS53</accession>
    <name>A0A3N6LS53_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91337">
        <property type="protein sequence ID" value="RQG91337"/>
        <property type="gene ID" value="EA462_05005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="137" mass="15852" checksum="749B63285C1C8E71" modified="2019-02-13" version="1">MSTNLEAAKGTKPRELIHFVTQQTRFALINNILQHPEQLPSMYELEELNPSVSDATVYKHIQKLIDAGIVNEVALDDDQRRQGYPWKFYGLTEEGRDFLEEHNLLAAEETLQQIYETISDKSEKMVKYENAPRPDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS78</accession>
    <name>A0A3N6LS78_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA double-strand break repair protein Mre11</fullName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mre11</name>
        <name evidence="8" type="ORF">EA462_08895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Nuclease activity is regulated by Rad50.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90104">
        <property type="protein sequence ID" value="RQG90104"/>
        <property type="gene ID" value="EA462_08895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02044">
        <property type="entry name" value="Mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032885">
        <property type="entry name" value="Mre11_archaea-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="7">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="465" mass="51315" checksum="6F14B00B1F8D6DA3" modified="2019-02-13" version="1">MTRVIHTGDTHIGYQQYNAPERRRDFLEAFRSVIEDAVTADVDAVVHAGDLFHDRRPGLIDLQGTVEVLRTLADAEIPFLAVVGNHEGKRDAQWLDLFADLGLAVRLGGEPEVVDDVAFYGLDFVPRSRRDDLEYDFGPVPDDADHAALVSHGLFEPFAHADWDTERLLSESTVEFDAVLLGDNHKPDTAEVLDTWVTYCGSTERASASERDDRGYNLVSFESEVAISRRGLTSTREFVFVDVSLEDDEGVDRVQESVRQHDLEDAVVIVTIEGDGRPIAPAAIEELAVDRGALVARVNDRRELPDEEEAVSVSFADPDDAVRDRVRELGFSDAALEIDRTVRDGDLPDSTVRESVERRVRELLEDDHDAFEPTSERDPETITTVADRRGNGGDETDGGAIESAAVEDETDSTDGVDESDTDSTDEIDGSDTNDTDERIERADRTDESDSTESDEQADASLGDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSD7</accession>
    <name>A0A3N6LSD7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90184">
        <property type="protein sequence ID" value="RQG90184"/>
        <property type="gene ID" value="EA462_09350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="602" mass="64160" checksum="09B6FA2F0F4626EF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSI4</accession>
    <name>A0A3N6LSI4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">EA462_01415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92908">
        <property type="protein sequence ID" value="RQG92908"/>
        <property type="gene ID" value="EA462_01415"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="45"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="113"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="175" mass="18699" checksum="8B19AA7FC9CEEDA2" modified="2019-02-13" version="1">MTNQELIDALREAEAVKFGEFELSHGGTSEYYVDKYLFETDARCLEAIADAFAQRVDDETLGGVALGGVPLAATTSVAAGVPYVIARKQRKEYGTGNLIEGRLEDGDEVVVLEDIVTTGTSLVDAVEALREAGATVERALVVVDREEGGRENVEDAGVEMESLVTASELLADADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSK6</accession>
    <name>A0A3N6LSK6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92933">
        <property type="protein sequence ID" value="RQG92933"/>
        <property type="gene ID" value="EA462_01550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="2">
        <location>
            <begin position="41"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="133" mass="14970" checksum="B235B48180BF6BCA" modified="2019-02-13" version="1">MRRDDRDEPFDDLFREIERMMNEMMNGADANVDFNSSSNVESGFGMDTHIDIHETEGEIRVVADLPGVAKEHIDLECDGKTLTISAGSEHHQYDERLSLPQRVNEHTASATYNNGVLEVVFEPAEKSSDISLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LST8</accession>
    <name>A0A3N6LST8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93043">
        <property type="protein sequence ID" value="RQG93043"/>
        <property type="gene ID" value="EA462_02190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="326" mass="37422" checksum="1312E29933692DC8" modified="2019-02-13" version="1">MQTNIRAWVAEMRDRFRDHPLRAPLYVIFTWYLVFWYAVTSRVPIGTNVYERDWDVLIVLDACRVDTLEAVAEEYEFIESVDSIRSVGSQSDEWMAKTFTERFRSQIARTHYVTANGHATQLFEQGELPPKNNTTPIDVSSWDLVDLDVFDDVTMVWQDHHDETYRVVLPRTMTDHAIQAGRANESDRLIVHYMQPHLPYIGQALDEGRPPTDLEMEGYNRLESNEANRSEVYDLYEDTLRLVLDDVAILLENLDADDVVITADHGEAFGEFAAYGHPEGFPHPVVKNVPWVRTSATDTGSRDPDLEISSGASVDVEEHLRDLGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT07</accession>
    <name>A0A3N6LT07_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91727">
        <property type="protein sequence ID" value="RQG91727"/>
        <property type="gene ID" value="EA462_06410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="109" mass="11611" checksum="6698541B57F34F55" modified="2019-02-13" version="1">MSLDCYADAIADLDPADGEIESTELVVTDDVLVKAFALGPDATLEPHEHGDSTNVFHVLEGTVTVIRDGERERIDAPGVVRHDRGVEHGAKNETDGTVVFTASLCPLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT15</accession>
    <name>A0A3N6LT15_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93133">
        <property type="protein sequence ID" value="RQG93133"/>
        <property type="gene ID" value="EA462_02710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043808">
        <property type="entry name" value="DUF5790"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19103">
        <property type="entry name" value="DUF5790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="142" mass="15084" checksum="21C267BE5D6A9EFE" modified="2019-02-13" version="1">MSQATFGDDELFGEAANEMREDVESSLSAGWEALPAADDIWESDADNVLGVLNGLNAVLDVGDAEDHLRDAKKWFTMGQRAEAFDDADDLEAEIGDLEDAIDDITAAGDQVGELTSTIPTLRGTLEDAGAEDSSVDDDDADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LU66</accession>
    <name>A0A3N6LU66_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II toxin-antitoxin system death-on-curing family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91084">
        <property type="protein sequence ID" value="RQG91084"/>
        <property type="gene ID" value="EA462_03525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006440">
        <property type="entry name" value="Doc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39426">
        <property type="entry name" value="PTHR39426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01550">
        <property type="entry name" value="DOC_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="162" mass="18454" checksum="E8E81E5976614E6C" modified="2019-02-13" version="1">MADSFWYPSVGDVLAIHDDIVSEYSDTHAGVQNRGDLEFALNYIEDGSFGTVPETIHGKAFHLIRLLVANHPFVDANKRTALNTTVVFYFLNGYRFAYDNEIRTILKQFGTDQTTVEEAETIEYLRSHTEEIDLIGEVEQWRDDLIRYGLDELTGDSSNPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUQ2</accession>
    <name>A0A3N6LUQ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91304">
        <property type="protein sequence ID" value="RQG91304"/>
        <property type="gene ID" value="EA462_04770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="209" mass="24035" checksum="6BB846110D13ACED" modified="2019-02-13" version="1">MGRDSEDEGVDTQEAIMRATYRALCKHGYANLTMQAIADEFDKTKGVIHYHYDTKETLLVAFLEYLLDAFNENIAVDENEEPETRLLTLIDTLLFGPPERGEFDHWELMVALLEVRSEAPYNEEFRRQFTHNYETIEATLVAIIEDGIDRGKFRDVDPQLAATLFLTALNGARIYQVALRRDDVAQLTRDGLEAIIDDWLRRSDASTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWP3</accession>
    <name>A0A3N6LWP3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">hisB</name>
        <name evidence="6" type="ORF">EA462_01715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93297">
        <property type="protein sequence ID" value="RQG93297"/>
        <property type="gene ID" value="EA462_01715"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="196" mass="21373" checksum="5C49548B77F396A7" modified="2019-02-13" version="1">MSERTATVTRETAETSIECAVAIDGDGRATVETGIGFFDHMLTAFAKHGLFDLEIDCDGDLEIDDHHTVEDVAIVLGTAIDEALEDRSRIVRYADRRVPLDEAVAGAVVDVSGRPRYYFEGTFSQDEIGGFTSDMARHFGESLAMNAGLTLHLEVDGENAHHEVEALFKALARALDDATRVDDRREGTPSTKGTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY15</accession>
    <name>A0A3N6LY15_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92724">
        <property type="protein sequence ID" value="RQG92724"/>
        <property type="gene ID" value="EA462_00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="152" mass="17287" checksum="63F5B802F885C01D" modified="2019-02-13" version="1">MTEFNGSWTEAEVMAFLRDATVPIRLATHRPDGSLWLVTLWYRYHDGSLECATQASAHLVRFLRDESAVAFDVSTNRIPYRGIRGTGTVTVSPDDGTAVLRALVDRYLGGDESALARRLLDDDREEVCIRIDPREVYSWDYSNRMDDVDERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY75</accession>
    <name>A0A3N6LY75_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II toxin-antitoxin system VapC family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86652">
        <property type="protein sequence ID" value="RQG86652"/>
        <property type="gene ID" value="EA462_16020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="137" mass="14959" checksum="49D418DAC831EEC6" modified="2019-02-13" version="1">MTDTIVFDTEPLIAYLDDEPGSDVVEAWIDRVASGEVDGYISPVTKTEVLHAGSRVGFRLDDVRASLDRLEELGVAVFDPRECWEIAAALKEAYTMALGDAYALATADATDGTLLVGADNDFDELEDDVERFRENPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY79</accession>
    <name>A0A3N6LY79_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Spt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spt4</name>
        <name evidence="4" type="ORF">EA462_00825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of Spt4 and Spt5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal Spt4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92804">
        <property type="protein sequence ID" value="RQG92804"/>
        <property type="gene ID" value="EA462_00825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00949">
        <property type="entry name" value="Spt4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007178">
        <property type="entry name" value="Spt4_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038589">
        <property type="entry name" value="Spt4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40704">
        <property type="entry name" value="PTHR40704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="SSF63393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Spt4" evidence="3">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="65" mass="7241" checksum="0488AC96272E7CC4" modified="2019-02-13" version="1">MVSDRLVCRECHRVNDPDNETCDACNSSSLTEDWAGYVVIAHPEQSQIATEMQVTEPGAYALKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYF4</accession>
    <name>A0A3N6LYF4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92894">
        <property type="protein sequence ID" value="RQG92894"/>
        <property type="gene ID" value="EA462_01345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="73" mass="8012" checksum="46BC3794D6534AC4" modified="2019-02-13" version="1">MSTGVSQSTGYGPNLQMSAFGWVMAIVLALMLLPVLPVVVLALILWKIFGEDEVIESQFETWRTASERQPNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ36</accession>
    <name>A0A3N6LZ36_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ORF">EA462_02830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93154">
        <property type="protein sequence ID" value="RQG93154"/>
        <property type="gene ID" value="EA462_02830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039018">
        <property type="entry name" value="VapC20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42188">
        <property type="entry name" value="PTHR42188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG93154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="146" mass="16272" checksum="35B293998B63BB41" modified="2019-02-13" version="1">MSVLIDTGVFVAAQNERDEHHDVAVRALTAGFNGEFGALYTTDYVYDEAVTLARIRTGSHREARLIGDRIAGRHSYPSGIELLFVHDDRFEKTVRTFERYDDHELSFTDASLIAVVKSEGLDAVLSFDDDFDGVVDRIDPTTSSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M025</accession>
    <name>A0A3N6M025_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88940">
        <property type="protein sequence ID" value="RQG88940"/>
        <property type="gene ID" value="EA462_11145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="78" mass="8486" checksum="63537FFC6631B718" modified="2019-02-13" version="1">MPVDRLIPEFLQREDGSESDDAVLHECRHCGSKFEEAIDQCPVCGATEIATYEFATDEGSSEDAGANSNERSDSGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M074</accession>
    <name>A0A3N6M074_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aconitate hydratase</fullName>
            <ecNumber evidence="6">4.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_11480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89000">
        <property type="protein sequence ID" value="RQG89000"/>
        <property type="gene ID" value="EA462_11480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006250">
        <property type="entry name" value="Aconitase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01342">
        <property type="entry name" value="acon_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="5">
        <location>
            <begin position="528"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="656" mass="70897" checksum="E028E132FAC2B2A6" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0B3</accession>
    <name>A0A3N6M0B3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2270 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87974">
        <property type="protein sequence ID" value="RQG87974"/>
        <property type="gene ID" value="EA462_14040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014470">
        <property type="entry name" value="UCP01500"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10028">
        <property type="entry name" value="DUF2270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015000">
        <property type="entry name" value="UCP01500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="232" mass="26463" checksum="E6E01DDACD52383D" modified="2019-02-13" version="1">MPEDTDELTRTELGRELNRDTTDLSSVLGDAYRGELDRETTWRSRLDQTTTWSVTIMAAILTWAFSSPDNPHYVILVGVIAVGMFLWIEARRYRNYDVYRSRVRLFQQNVLANALDPSTGVEHADWRTELGDDYRRPTLKITIFEAVSNRLRRIYFALLSVLCLSWLFRVTAFMPGESLPDAASIGTVPGAVVLAAVGAFYGVLLVIILWPHEREAKEEFRKTEAGEWKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1Y6</accession>
    <name>A0A3N6M1Y6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89800">
        <property type="protein sequence ID" value="RQG89800"/>
        <property type="gene ID" value="EA462_07210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025758">
        <property type="entry name" value="Fic/DOC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026287">
        <property type="entry name" value="SoFic-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13784">
        <property type="entry name" value="Fic_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038925">
        <property type="entry name" value="AMP-prot_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="136"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="393" mass="44854" checksum="70216CC97350F90A" modified="2019-02-13" version="1">MDRNRFAESAPGELVTTTIDGYETPSFIPDSLDTIELDQGEFTKEIGQAMRMLGALEYIGPKAGSSTMLIEAFARKEAVHSSRIEGTQVTLSDMYRYEAQQAVGETSSDHEGARQAENYLEALQTGLKAIERDERITVDTLCEMHSILLDGVRSEDPSPGEIRDQQNYLAPFEDADISQATFVPPPPTQAHEKLDALLEYANAPQPIHSLLKLGVIHYQFETIHPFRDGNGRLGRLLVSLELQREELLTEPYLYLSAYFNEYRGDYTNLLTQVRTRGSWDDWLHFFLRGIWQQAKEGVKRGERLLELRREYVTEYQTHRSEYILPVTQQLFKNPYITAKQAEQQFKFSHTTAYSLIETLEEDGVLTEVESDGSSRLYQATEIYELIDTPLSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3L7</accession>
    <name>A0A3N6M3L7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR04076 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86707">
        <property type="protein sequence ID" value="RQG86707"/>
        <property type="gene ID" value="EA462_16345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023811">
        <property type="entry name" value="CHP04076"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04076">
        <property type="entry name" value="TIGR04076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="112" mass="12407" checksum="56F91376EA156C9A" modified="2019-02-13" version="1">MAKISSETEFTVYDLRVECVEINGDAEGSYDVGDYFEVHGENLVFPEKQTFPIYALSALIPLLPAKQRESDSNDWMSTPVKVTDPDPDVDGTFEISRIGERTVTPKSASDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3Q7</accession>
    <name>A0A3N6M3Q7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89841">
        <property type="protein sequence ID" value="RQG89841"/>
        <property type="gene ID" value="EA462_07430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="390" mass="42179" checksum="EEE5AAA2800A1C64" modified="2019-02-13" version="1">MAIVDGHQQTTEVGAAENELSLVGSKISEVTLGESTAQTVSVSGQSGTYGVNETAGRMEITHYNRTGTDTGELIGNETFSLGEITYATDGETIAYQGGGVWKHDGDHTTMVSPPEFHYRYGTLTLPIINVTGDGQRTGKTDIVAQRTSETERIFPNSSRTYDDGTVYQNPIENGTVEVTVHSEYYLGWERYFQDRTQGNVSVDHENETVNVELITLGDQGLTPLSDGGDIRIRAAQEDDPINEFTLTLAGDGSSGLNNLDWSLEVDGTEVANVHGQGHGGVDTTITDATGEEWTAEDAFEVNQSADPETVTINLTSDVIAQNASGSERELGALFNETIEAYGPNVDLTVEDKSGAQRVDHDESEGYIDYEAEGFVTYLQITENTADVRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3U8</accession>
    <name>A0A3N6M3U8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">YeeE/YedE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_07725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89891">
        <property type="protein sequence ID" value="RQG89891"/>
        <property type="gene ID" value="EA462_07725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="7">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="166" mass="17160" checksum="CFA5B6B9CF989112" modified="2019-02-13" version="1">MTATLSLFVALFAELFPNGISHYAIGGLFVGLGVAVIYLGTGTAAGASTFLESTLSYGSSLSRFQQYRPSRDWRIVFTVGIVIGAAIYAVTVSPQDGLWTTDVQWWRLFVGGVLIGIGTRVGKGCTSGHGVCGVGSVSSASFVGVATFLFIAIGTAQLIQAVGVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M401</accession>
    <name>A0A3N6M401_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0212 protein EA462_08045</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0212 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89951">
        <property type="protein sequence ID" value="RQG89951"/>
        <property type="gene ID" value="EA462_08045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01223">
        <property type="entry name" value="UPF0212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007564">
        <property type="entry name" value="UPF0212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42199">
        <property type="entry name" value="PTHR42199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04475">
        <property type="entry name" value="DUF555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="165" mass="18279" checksum="C6DD79DC93C4B102" modified="2019-02-13" version="1">MNCRVVVEAAVPVFDVGTEDEAIRIAISKTGEMLNPDLNYVEIDMGERTSPSGEELPPAFIAADEALVALELEMTVFNVEREEHASRIARKEIGQRLENIPLEVIDIDVIEDEDTDGDTDDEDETVDDAEDSDDDPADEDDSSQSETTDEESSDEILPEFEDLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M421</accession>
    <name>A0A3N6M421_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89971">
        <property type="protein sequence ID" value="RQG89971"/>
        <property type="gene ID" value="EA462_08165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="113" mass="12816" checksum="AF1204686BAB156F" modified="2019-02-13" version="1">MSSTEHAEGGREQKKELRKDHPSGWLHLTQHDAIPILVDALLDLPPNREFNKTEFAEHAGVTRQTVGNYTDLLLEVELIEEVPNTSPRRYRVADSDVVRELFELNSALNNVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M477</accession>
    <name>A0A3N6M477_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86957">
        <property type="protein sequence ID" value="RQG86957"/>
        <property type="gene ID" value="EA462_14970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043821">
        <property type="entry name" value="DUF5799"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19113">
        <property type="entry name" value="DUF5799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="154" mass="16633" checksum="A2655E9A9B030399" modified="2019-02-13" version="1">MSEPSWTDQIVGERMTVDQEFSTHIQDSQFSNQEWSLIMTATTFEIEQPDDPEQARMVANTDQVDQVIPELENIQSSMGAMGAEGGSQPSSSGGGIVDSIKGALGFSGTTDSGSDEAKLEAAEDLTQKYAAELQSHLESNGRWESVREAASPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M481</accession>
    <name>A0A3N6M481_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxoacid:acceptor oxidoreductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_08475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90031">
        <property type="protein sequence ID" value="RQG90031"/>
        <property type="gene ID" value="EA462_08475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="3">
        <location>
            <begin position="13"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="209"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="585" mass="63993" checksum="FC47B6C0C696218D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M593</accession>
    <name>A0A3N6M593_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87879">
        <property type="protein sequence ID" value="RQG87879"/>
        <property type="gene ID" value="EA462_13530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="273" mass="30842" checksum="C3524FEE77588871" modified="2019-02-13" version="1">MEYEYIELSVEDDVGKITLDRAEKRNAIVPELALEVTDALERIEDEIRVLVLEGNGSAFCAGMDLEKRFYETRQEGPRAFYEAGRKTGSMFTTLFDYNRPTVAKIDGWTFGAGYCLQAVCDFAVTTEESVFGLSEINFGIIPGGGAMWAAVNTMNRRKALYYTSTGESFTGATAEELGAVTTAVPEDKLEETTDELIESLAEKNPIAMQFNTAVLERVRYMDFHEALDYERGKSEEMKYYQQDEWVDEGIGQFKEREYKPGLESYDEQSEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5G3</accession>
    <name>A0A3N6M5G3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor IIB</fullName>
            <shortName evidence="6">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tfb</name>
        <name evidence="9" type="ORF">EA462_04520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91260">
        <property type="protein sequence ID" value="RQG91260"/>
        <property type="gene ID" value="EA462_04520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="6">
        <location>
            <begin position="134"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="6">
        <location>
            <begin position="228"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="317" mass="35557" checksum="BA29A753815281C5" modified="2019-02-13" version="1">MTQSIIDHTRPESERTDAERCPDCETETIVHDPDRGERVCADCGLVLTEDPIDYGPEWRAFNAQEHDELSRVGAPLTQSMHDRGLTTTIDWRNRDANGHAMSAEKHGQIHRLRVWQERIRTKNAGERNLKYALSEIDRMVSALGVPKPVKETASVIYRSALEKDLIRGRSIEGVATSALYTACRKEDIPRSLEEVTSVSRVDQREIGRTYRYIADELDINLEPTNPRQFVPRFCSELDVDNDVETKAIEIIDQTTAQGLHSGKSPTGFAAAAIYAAGLLCDETIPQRAVANTAQTTVVTVRNRYREQLEAIDRAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5M6</accession>
    <name>A0A3N6M5M6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88049">
        <property type="protein sequence ID" value="RQG88049"/>
        <property type="gene ID" value="EA462_14460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="54"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="446" mass="48073" checksum="51D02FA222C02A1F" modified="2019-02-13" version="1">MSDVDTQFSGGRVYHAGELMDLTVGVTDGTVTHLARPGTALNATEQIELDGEWILPGFVDGHIHLREPGYVEKEGIETGTAAAAAGGVTTIVEMPNTTPPVLDVDRLEEKAARFARDSHVDHAFFGAITEENVGTGNIEALAEAGITAFKTFMATSFGPLLMDDKGVLYRAFEEVSDTGLPLYIHAEDEEYLDEFTTRCKDQDGMDAFFDSRPPIAETTAVSDVLDMVEATGAETVIAHVTTAEALSRIRDGRADGLPVHAEVTPYHLTFDRSDVAAIGTAAIGTPPARDSQNFEGLWTHLRNGDVQLLGSDHAPHRLEERDQPPLEVPPGMPQLETAVPAMLEAIDRGRLSVEKLVELYAESPARLHGLYPRKGTIRPGADADLVVVDPDREWEVDATRFESAADYSPFDGMTLTGMATAVYQRGTMIAKGGETVSEPGDGIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5S8</accession>
    <name>A0A3N6M5S8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88109">
        <property type="protein sequence ID" value="RQG88109"/>
        <property type="gene ID" value="EA462_14575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="272" mass="30056" checksum="0CB184774E8BBEAC" modified="2019-02-13" version="1">MNRFFRITRKLPGSRPVISTLVALQIVFLMLPTIVVFVVSFQPGDIVRFPPDGLSLQWYYELPDESRYISALWRSVLVATFCMLLSIPIGILAALGLIRYDIRFEKAFQLYFLLPFTVPLVVSGVILLIIFGEMGVIGNLWTVGLALTIINIPFMIWSVTSRVNALDSELENAAKNLGADEIQTFFNVTFPSIMPGVVTGALIMFVLGLNEFIVSLIITTPDIVTLPVLIYTSIRTNISPLIAAVASVYVIVAFLAVIVADRLVGLDELLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7C3</accession>
    <name>A0A3N6M7C3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DegT/DnrJ/EryC1/StrS family aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91241">
        <property type="protein sequence ID" value="RQG91241"/>
        <property type="gene ID" value="EA462_04420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="420" mass="44908" checksum="9D9E59E12C8506EB" modified="2019-02-13" version="1">MTDTTETETETDATVESRTNDRSTDGGVDADSSGGAAGSRSRPSADAEGRRDEPIAIADPALGDDAKRRVESVIDAGELADGPEVRAFEAAFADYCRTDEAVATSNGTTALHAALEALGVDNGDAVVTSPFSFVASANAIRLAGGTPVFADVDPETYTLDPHDVERVLAERDDVVGLLPVHLYGLAADMPSLCDLADDHDLFVLEDACQAHGAEIDGDRAGGLGDAACFSFYPTKNMTTGEGGIVTTDDADLADRISSYVNHGRETSGTGGYEHVRLGHNFRMTSLAAAIGRAQLERLPDLTRTRRDHAAYYDDRFDDLSLETPTEPPGYRHVYHQYTVRVDDRDGLRDALESRNVDSAVYYGTPIHRQPAYETVSTAAAQLPKAERAAETVLSLPVHPGLSTRDLETVAETVRDSLETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7Q0</accession>
    <name>A0A3N6M7Q0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl15</name>
        <name evidence="8" type="ORF">EA462_05135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91361">
        <property type="protein sequence ID" value="RQG91361"/>
        <property type="gene ID" value="EA462_05135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_prot_L15/27a_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="163" mass="18100" checksum="BA5C12129E4C55FA" modified="2019-02-13" version="1">MTSKKRRQRGSRTHSGGTHKNRRGAGHRGGRGRAGRSKHEFHNYEPKGKHGFKRPHDIRDEVAEIDVQKLDEDAILYVADDLADETDGGYELDARDIVEDGYDVDIVKVLGSGQVRNQLTVTADAFSETAREKLEAAGGEAIVSERAQEDDAETDDEPEQNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M853</accession>
    <name>A0A3N6M853_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91531">
        <property type="protein sequence ID" value="RQG91531"/>
        <property type="gene ID" value="EA462_06110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="9531" checksum="51DFDE61A3E22863" modified="2019-02-13" version="1">MRKRAEWMTRADDEILEYLESRGAGTPKAIAGEIDRNNDYVGVRCRQLASYGLVDRPSRGFYVITDQGTAYLEGELDASRLEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8J8</accession>
    <name>A0A3N6M8J8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle 19 kDa protein</fullName>
            <shortName evidence="5">SRP19</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">srp19</name>
        <name evidence="6" type="ORF">EA462_07140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89786">
        <property type="protein sequence ID" value="RQG89786"/>
        <property type="gene ID" value="EA462_07140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00305">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022938">
        <property type="entry name" value="SRP19_arc-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="PTHR17453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SSF69695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="93" mass="10325" checksum="EC7072314A4F0188" modified="2019-02-13" version="1">MVENVIWPAYLDVELSRAEGRRVSGELAVDEPTVDEIAKAVQQIGYDATIERDKAYSREPWAERGRVVVRGADDSSKTDLVQAVAAYVVAMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8M1</accession>
    <name>A0A3N6M8M1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rhomboid family intramembrane serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_07290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89816">
        <property type="protein sequence ID" value="RQG89816"/>
        <property type="gene ID" value="EA462_07290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="7">
        <location>
            <begin position="86"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="612" mass="65516" checksum="F1D08276A013B15E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8N3</accession>
    <name>A0A3N6M8N3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89826">
        <property type="protein sequence ID" value="RQG89826"/>
        <property type="gene ID" value="EA462_07355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005530">
        <property type="entry name" value="SPW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03779">
        <property type="entry name" value="SPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="153" mass="16107" checksum="DF7A25A1F097152C" modified="2019-02-13" version="1">MSESTTTDPAGETPQMQGRDEPEAQKWLSGIVSLIGLWIAASPFVYEAVVAFTWNNVVIGGAIFLLAGYNYYRIVTDHPTSTSVMSLVALLALWTLVAPFALEGQFAMEGLEVAASALVWSNVVFGIIAAAMAAYIAYAGGRGVRAGTAAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9N0</accession>
    <name>A0A3N6M9N0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TraB/GumN family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90236">
        <property type="protein sequence ID" value="RQG90236"/>
        <property type="gene ID" value="EA462_09640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PTHR21530"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="590" mass="63137" checksum="2974529EBBFAF134" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBM9</accession>
    <name>A0A3N6MBM9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92871">
        <property type="protein sequence ID" value="RQG92871"/>
        <property type="gene ID" value="EA462_01205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="404" mass="44753" checksum="0F51F375FEB61C5F" modified="2019-02-13" version="1">MYDDLIDSGELPIARKSVLPGTGFFLPDTLEDDLEEERTEAALEGTDVAVIADPDADGLACVALLREYYDDVQRVPQPDVDESDSDREVESDEDETATAQTGESEAPLAELEPTPHGVALVPASPHDVEDALARVGEYGDRGIDIYVCDLCPDRYEYVEDELQAALETASGVAWYDHHQWDDDVADAVREAGVDLVVGDSDEECSADVVYRSLEYEFDPIYEELAAVTRDHDLWLREDPRSDDLADYAYWTDPGEYVEVVREHGADLPEWVQSYITERRVEKEALIDRAVARSELREIGEYTVGITYGRCSQNEVAEAMRENGADASVVVKPAGSASIRGTDEFDRCHEVADRVNGGGHPKAAGCKPDIYDDMLDYATHWTSRGAVTKRVILDAFREVVEDGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBU7</accession>
    <name>A0A3N6MBU7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92951">
        <property type="protein sequence ID" value="RQG92951"/>
        <property type="gene ID" value="EA462_01665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="75" mass="8037" checksum="EE16B18415306C84" modified="2019-02-13" version="1">MIAGLTDRFRSHPVATTLELGSVITCVFLFIGTFVLLASGLPRGVGTPWLVIVTVGAAFVVFWTALVPLYERAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MH18</accession>
    <name>A0A3N6MH18_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93286">
        <property type="protein sequence ID" value="RQG93286"/>
        <property type="gene ID" value="EA462_01090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="194" mass="21939" checksum="A45BE4B6D36005B6" modified="2019-02-13" version="1">MSTDSEGGDGATDPLPKGEIFEVLRNQRRRYVLHYLKQDDRPVELGDLAQQVAAWEYETTLEDVTPEQRKRVYTTLQQTHLPRMDEAGILTFDSDDGVIAGTDRTRDISVYLEIVPSHEFAWRELYLSLGAISCALVAALWLEIYPLTLLSALTWTGIVAVTITATAVAHIYHERHMRLGHGEQPPELSFRTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MH47</accession>
    <name>A0A3N6MH47_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_03150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93326">
        <property type="protein sequence ID" value="RQG93326"/>
        <property type="gene ID" value="EA462_03150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="7">
        <location>
            <begin position="147"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="304" mass="32701" checksum="3DFBE2D91B77E063" modified="2019-02-13" version="1">MTKVSVVGAAGTVGAAAGYNIALRDVADELVFVDIPDQEDTTIGQAADTNHGVAYDSNTTIRQGDYEDTAGSDVVVITAGIPRQPGQTRIDLAGDNAPIMEDIGSSLAEHNDDFITVTTSNPVDLLNRHLYEAGDRAREQVIGFGGRLDSARFRYVIAQRYDVPVQNVEATILGEHGDAQVPVFSKVRVNGRDLEFTDDEKTELLEELQTSAMNVIEKKGATEWGPATGVGHTVEAILRDTGEVLPASVVLEGEFGHEDTAFGVPVKLGANGVEEVVEWDLTEFERNQLGEAAEKLSDQYDKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTG2</accession>
    <name>A0A3N6MTG2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88095">
        <property type="protein sequence ID" value="RQG88095"/>
        <property type="gene ID" value="EA462_13280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05018">
        <property type="entry name" value="CoxG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="166" mass="17957" checksum="DB8E975E4C63EAD8" modified="2019-02-13" version="1">MIFDGEFETHRAPDELWTYFADPDIVADCAPGMEEMNHISDSEYEATITVGVGSVKPTFSVDATVLEMEEPEKLVMKAEGSGGRKGAFDAVSRMEMTESEDGGTILKWEAEANVSGIIASLGQRALGSVAERLIGQFFDCMEGKVEEGVDATPRMAPKPDVEADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MU39</accession>
    <name>A0A3N6MU39_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase/muconate lactonizing enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88902">
        <property type="protein sequence ID" value="RQG88902"/>
        <property type="gene ID" value="EA462_10940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050401">
        <property type="term" value="F:xylonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034624">
        <property type="entry name" value="Xylonate_dehydratase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00564">
        <property type="entry name" value="xylonate_dehydratase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="165"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="412" mass="45832" checksum="426834DD264AB9F3" modified="2019-02-13" version="1">MGVDYSTLHDPNAEYTMRELSAESMNVTRERGGGRDVEITDIQTTMVDGNFPWTLVRIYTDAGIVGTGEAYWGAGAPELVERMKPFLRGENPLDIDRLTEHLVQKMSGEGSIGGVTVTAIAGIEVALHDLAGKILETPAYQLLGGKYRDEVRVYCDCHTEEEADPVACADEAERVVEELGYDALKFDLDVPSGHEKDRANRHLRDVEIDHKVSIVEAVTERLGHRADVAFDCHWTFSAGSAKRLAKRLEEYNVWWLEDPVPPENHDVQREVTQSTTTPITAGENVYRKHGQRRLIEEQAVDIVAPDMPKVGGMRETRKIADLADLYYMPVAMHNVSSPVATMASAHVGAAIPNSLAVEYHSYELGWWGDLVEEDVIEDGYIEIPERPGLGVTLDMDAVAEHMVEGEELFDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWM9</accession>
    <name>A0A3N6MWM9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">YeeE/YedE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_07730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89892">
        <property type="protein sequence ID" value="RQG89892"/>
        <property type="gene ID" value="EA462_07730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="7">
        <location>
            <begin position="40"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="155" mass="16582" checksum="C12E4384821855A4" modified="2019-02-13" version="1">MSPEHDQHPLFLPLVFVGGLLFGFGLGFSHMAQPEVVLSFLQFTDFGLLFVMFGAAIVTGITFFGVKQFRSRAPLTGAVYERRLKSLDKNVVIGGGIFGIGWGLSGICPGAAYASLGIGNVPILYGIAGMFVGAYIQGFWRSARTERNTPATTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MZW5</accession>
    <name>A0A3N6MZW5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_03920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91152">
        <property type="protein sequence ID" value="RQG91152"/>
        <property type="gene ID" value="EA462_03920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006686">
        <property type="entry name" value="MscS_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01246">
        <property type="entry name" value="UPF0003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="400" mass="43891" checksum="5EA8F57815F9F7D7" modified="2019-02-13" version="1">MSEVLAGLDWLARSVETTELKVAVTVGAATLLLLVLLSYRRVQSWISERTKPLYGDIASTVLLTATFVVALAVVIGVWDQTETLRQGYDELDMGGQILARAVVSFILIVGTLIFRRFVKRILDELLGSASAVTDHQREISHRIAQVIIWSVSLVVVLGVWIDDLSGLLVGAGFLGIVVGMAARQTLGTVLSGFVLMFDRPFEIGDWIEVEDREGIVTDISIVNTRIRSFDGEYVMVPNDLVASSMVTNRTKRGRLRIEIDVGVDYGSDVERAGELAEAAVSELEHSLSAPGTQVVTKRFGDSAIVLGVRFWIDNPSSQRRWKARTAAIGAIKRRFEDENIGIPFPQRELSGRDGTAVHVDATDDGRSDSEDDVSPRSDSDASADEPTEPREYRMTQPEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N027</accession>
    <name>A0A3N6N027_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91212">
        <property type="protein sequence ID" value="RQG91212"/>
        <property type="gene ID" value="EA462_04270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="69" mass="7363" checksum="DE52A8D59C010378" modified="2019-02-13" version="1">MCAGRHGSPSLRAPPSHGLVRLNTLLRGATLLRTTPYAGLMMLLASQDFRRRVLGPGPSPDGRGVRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N117</accession>
    <name>A0A3N6N117_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">crcB</name>
        <name evidence="7" type="ORF">EA462_06700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91632">
        <property type="protein sequence ID" value="RQG91632"/>
        <property type="gene ID" value="EA462_06700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="140" mass="14632" checksum="C80E986D254FB385" modified="2019-02-13" version="1">MPDDHPLVRLETLALIVIGGFAGANLRFFALGLVSDIVAVLAVNVLGSFLLGFLVYEAEYMDVLERNSRLLFTTGFLSSLTTYSTFAIQTAVNAGPAEPLLLAAVVVGNYGLGFVGVLASRSLARRVAAETAHSAGGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N459</accession>
    <name>A0A3N6N459_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">A24 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_01670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92952">
        <property type="protein sequence ID" value="RQG92952"/>
        <property type="gene ID" value="EA462_01670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009655">
        <property type="entry name" value="Preflagellin_peptidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06847">
        <property type="entry name" value="Arc_PepC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Arc_PepC_II" evidence="4">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG92952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="331" mass="35452" checksum="9881D6407FF646AD" modified="2019-02-13" version="1">MTLSGTFATVPDLLRLVAVPVFAWVAIRDVKTRRVSSSVWIPFSLLGAVLLVWDGVLAWNAGGGRWLAFLVPAAISLGFVVPIAYLFWWFGGFGGADAKALLVIALFFPTFPQYAVGSWTLPLSITPIGAFSFTILTNAVLVGVTIPVALAIRNAAAGRIAPVMFIGWPTAWNRVPQTHGSLLETPAGLTRRGLDLDALRMYLRWRGLSLTEIRDQPGRYRDPTTLPDEPNPPTDGAVTASGPPLGDGGDVEMPELTDESVGTDPWGADAFLADIEGTAYGTTPDELRDGLEVLATEETVWISPGTPFLVPVFVGLVIALVYGDLLLGTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4Q5</accession>
    <name>A0A3N6N4Q5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93172">
        <property type="protein sequence ID" value="RQG93172"/>
        <property type="gene ID" value="EA462_02920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="73"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="249" mass="27053" checksum="1CF0386871CB9C20" modified="2019-02-13" version="1">MERRKLLVSTGALAIGGVAGCLDGDDQPDESGETTASGSDEQPVVNGEAYPTMNYDDVDVPLAPLEDVYEWYDSDAVSVVDTRSEHQYEVSHIAGAALSPAPTGPDSDDPVEAWDEDGLIVTYCVCPHAMAVQRAAALIQDGYENVYALDEGFNAWIEAGYPLEGDDVDEELPAFDVQGRTDPAYEGEFVWIRDPVTGQREPGQIDADGRYEMTLYFTDVDDDTVLEVDGPEYTHELTLAEITSDVITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NU62</accession>
    <name>A0A3N6NU62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86670">
        <property type="protein sequence ID" value="RQG86670"/>
        <property type="gene ID" value="EA462_16135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="101"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="328" mass="37483" checksum="F79AE43C061CBA1F" modified="2019-02-13" version="1">MVRTTRQFRSRLADLHLGSYLPLYNRLTEQQRFAYKLLAPGLAMMFLIHFIPIIWGTLISFLGVDSSYIYRWHAAPFVALENYQYVLDPRTVVGGRFWFSVRQTVIFAVGTLVVTYVLGLTAALVLNQKFKGRFVARTLLLLPWVAPVVVTLLIWRMMFQQQSGIINNILMSIGVINEPIYWLIGDNAIWTLVLTHSWTQFPLVMIMLYAGLQSIPEQLYEAAAIDGAGRWEKFRHITFPQLKPVSAVVVLLVMLWTMINFTAPYVLLGAQPPRAGQVSILYIYDFAFSNFQFGRGAAMSVVLFAIAMTMALAYYKYLFDEDFTEGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVJ9</accession>
    <name>A0A3N6NVJ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87872">
        <property type="protein sequence ID" value="RQG87872"/>
        <property type="gene ID" value="EA462_13495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="63" mass="7025" checksum="3975350E70497787" modified="2019-02-13" version="1">MNRPEQQIVDGYSYVLPAKYREALDSHTSDSHVVSGLLGSIPQLTDVDRRLDSWTDTASTSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVV6</accession>
    <name>A0A3N6NVV6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88032">
        <property type="protein sequence ID" value="RQG88032"/>
        <property type="gene ID" value="EA462_14365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="450" mass="50946" checksum="79CC17E6FDD73D77" modified="2019-02-13" version="1">MTDSRPNIILMQCHDLGQYLGCYGTDVETPRIDELAESGALFENHFVTAPQCSPSRGSFMTGRYPHVNGLMGLAHGNWELEAGETILPQYLSRNGYETHLFGLQHITQDTDRLEYDYVHSEGNLYPGVSPSVHQVNRARSVADVVSGFLDRGAFESPFFATVGFFELHRVEEENGRFGFDGDRYDTDDPDEVRPLSYLPDRRGIRHDVAEMHGMVYALDDAVGTILDSLESTDLSQETLVIFTTEHGIAFPRAKGSCYDAGIEAALVLRCPEIADDGSRYDELISNVDVLPTLLDLLEIEIPATLDGRSFASMLSDDGAYASHDHIFAEMTWHDMYNPVRAVRTDRYKYIRSFWHLPKVYLTKDIFASEAGRMVRETDGVPPRPYEELYDLTESPQEDENVVYEPKYQETRLDLSRILREWMIETDDPLLNGPVPPGDYEEITAWPSDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVZ6</accession>
    <name>A0A3N6NVZ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_13975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88102">
        <property type="protein sequence ID" value="RQG88102"/>
        <property type="gene ID" value="EA462_13975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="68"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG88102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="505" mass="55182" checksum="DF874DF71D1FE7FC" modified="2019-02-13" version="1">MLAGAVSGGVAAVGGCLSDSSGRPDDNSSVSIALEDDPTADSWDTYGYVTPYFTKVVEPLIWATESMEPTPWLATGWEAVDETTWSVTLRENVSFHNGEEMTATDVVWSFERLFERGQFVSGWLHLEPENVVAVDEYTVEFTNTEPFPAFPGTIAHNMICVQHPDSTADDLGTIGTGPLTIEAVDRGSTVETSPFADYWQDGVEVPLSFEVIEDPSTRALSLESDDVDVIFNPPRNRVEPMRDDPSLSVLTQQSSRTMFLPCNLYRPPTDDARLRRALNYAVSQSELVDTVLEGIDDPARGPISPIVHWSAHDGLRTYDRDLDRARELVEQSDYDGEPLVLAVNASVVSGELIAEAVAGAFTEIGVETDITVVDPGSYNEYVQAGNAHLGLQTSGSNSAAADYIMFENFHSEGVSNAQLFEAEGTGVSNPGKAVDELIETAYQSRNAETTATAYRDAQHRLVEEAVCLPICHVVHVIAARTEIEGIDPHPIDKMVDWSDLSREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWV0</accession>
    <name>A0A3N6NWV0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="4 13">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpA</name>
        <name evidence="15" type="ORF">EA462_11820</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="4 13"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89059">
        <property type="protein sequence ID" value="RQG89059"/>
        <property type="gene ID" value="EA462_11820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005726">
        <property type="entry name" value="ATP_synth_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01043">
        <property type="entry name" value="ATP_syn_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rhodanese" evidence="14">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="239"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RQG89059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="587" mass="64822" checksum="CB5F82355723ABEE" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWZ8</accession>
    <name>A0A3N6NWZ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protease HtpX homolog</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">htpX</name>
        <name evidence="13" type="ORF">EA462_12265</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M48B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89139">
        <property type="protein sequence ID" value="RQG89139"/>
        <property type="gene ID" value="EA462_12265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="12">
        <location>
            <begin position="75"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG89139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="295" mass="32472" checksum="CBFCA4EF8406CD85" modified="2019-02-13" version="1">MNWQADWGLRFRMFLTMFLLFVLYIVFAGAITLYTGSGPLLFALLFGGFSLVQYYYSDTLTLRSMGARTVSADEYPQLHASIERLSQQADLPKPTVAVVDSQVPNAFATGRNQRNAAVAVTTGLLRTLERDELDGVLAHELAHVKNRDMMVMTIASFLSTIAFMMVRWGAFFGGGRGRGGGRGGGGIVVAILVSLVVWIISYLLIRALSRYREYSADRGAAAITGNPAALASALMKISGEMDRVPKDDMREEAEMNAFFIIPIRSGVVGRLFSTHPPTERRIEQLRELEQGMTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYF8</accession>
    <name>A0A3N6NYF8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gas vesicle protein GvpFL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_07540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89859">
        <property type="protein sequence ID" value="RQG89859"/>
        <property type="gene ID" value="EA462_07540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="317" mass="35133" checksum="5ABBECE09BC271CC" modified="2019-02-13" version="1">MSFDDGSDRLEGVDAGAQGAIDAGERTATGADTGDVPALEEGRYLYCLVRADSEDTLETTGVESQPVSLVAYDEVAAVVHPCDEIYDSADLAQVRRWLVRHQTVVDEAGDRFGTPIPFQFDTILRGDDDDVREWINQEYDTIEPTLSELADHWEYRVEVVETDPVDDEALVQRDDRLRELDAKIGNSEEGTAYLLEKQFDQRITQLRVSRRESLTADLEDRLADEAREVHSLERSPTVSLSDDPADETNGTAGEETLCRLTILAHEDDEGAIGSVLDDAASNDGLEIRFTGPWPPYTFAPELGEDASNRGLARDQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYP5</accession>
    <name>A0A3N6NYP5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89979">
        <property type="protein sequence ID" value="RQG89979"/>
        <property type="gene ID" value="EA462_08205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="161" mass="17650" checksum="A8215AA3812F182D" modified="2019-02-13" version="1">MASEDHQDGGVSFALPPDVDDWIRTEADRRGETREEMCRQMVVAAHHVSADDGLDPGAELVDRSEIEFLEGALDAQREGFIDLIEDVRSRVVQVKPDDDSGESDTTIADLLGERLRPPSSELHSSGGRTEESRPRSKLGRGGFCARSRSVLRCSSVTTVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0Y9</accession>
    <name>A0A3N6P0Y9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="3">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">icd</name>
        <name evidence="7" type="ORF">EA462_03845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91139">
        <property type="protein sequence ID" value="RQG91139"/>
        <property type="gene ID" value="EA462_03845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="PTHR43504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00183">
        <property type="entry name" value="prok_nadp_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="6">
        <location>
            <begin position="32"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="420" mass="46293" checksum="34A062CDEB07494B" modified="2019-02-13" version="1">MSYEKIDVPENGKKITLKDGSNDQLEVPDNPIIPIIYGDGVGSDVGPAAQQVLEAAADATGHEINWMRVYAGESARDKYGENLPDETVEAIKEHRVAIKGPLTTPVGSGFRSLNVGLRKLLDLYANVRPTYHLEGVPSPVTTPEQMDMITFRENTEDVYAGIEWEAGTDEVEQVKEFVEEEMGHDNVIHDGPVGIGVKPITEFGTKRLVRRAIDYALEHDRDSVTLVHKGNIMKFTEAQFRDWGYEVAEEEYGDEIITEDTLWEERDGDAPDDAVVVNDRIADNMLQQLLTRTDQYDVIATMNLNGDYMSDAAGAQIGGLGIAPGANFGDGRLLAEPVHGSAPKYEGQDKVNPTAMILSGRMMLEYLGWNDAADLVRDAVEETISSGKVTYDLERQLEDAEKLATSEFAREVVDNIESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0Z9</accession>
    <name>A0A3N6P0Z9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1610 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91159">
        <property type="protein sequence ID" value="RQG91159"/>
        <property type="gene ID" value="EA462_03960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044720">
        <property type="entry name" value="HVO_2753-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011668">
        <property type="entry name" value="HVO_2753-like_ZBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40733">
        <property type="entry name" value="PTHR40733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07754">
        <property type="entry name" value="HVO_2753_ZBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HVO_2753_ZBP" evidence="1">
        <location>
            <begin position="12"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="6345" checksum="96C616FB853249D3" modified="2019-02-13" version="1">MSTTDDREIRSCVSCGINIAGTNAAAFKCPDCGAQIYRCAKCRKQSNLYECSKCGFTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1G2</accession>
    <name>A0A3N6P1G2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88915">
        <property type="protein sequence ID" value="RQG88915"/>
        <property type="gene ID" value="EA462_11005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="253" mass="27253" checksum="85F77B74D53FB4AE" modified="2019-02-13" version="1">MSLAFAASIDGETVLVAVLVALVTVAHLLPDELSVSVGLSRHDLLSLTGGVSIVYAFLHLLPELDERQEALEGVPVLVWSLASHHVYAVAFVGLALFYGLERLARMSRSYGVERELGSVGEEPVFWIHVGGFAVYNAFIGYALVQGETGTDNVALFGVAMALHLFGNDEAMQHHHRELYSRFGKWILAGAVVLGAAVGVGYTIDDVTVTTLLGLLTGGILFNSIKDELPRTRESRFWPFALGSGTYAVVLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1P7</accession>
    <name>A0A3N6P1P7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CbiA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89015">
        <property type="protein sequence ID" value="RQG89015"/>
        <property type="gene ID" value="EA462_11575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="432" mass="45440" checksum="EBDADE1AA647FDB6" modified="2019-02-13" version="1">MIAIAGSKGGCGKTTVTVGLARAFARAGDPTVAVDADRQLPNLHAVANVDRTPTLATVEADAVGAAVQPLSGTTGAGVIAAPDTTDRIDLETALDRLGNEDVRILLDCPSGCGPDVTDPLAVADAVVVVTTDTDRARRGARTTIELARRLEVPVAGAVVTKHGGETETIGSELGIPVLGTIPEHDAPLSADATERAFDHVVDRLRRESFPDRARAATDSNRLSTGICALDGALGGGFRPGSVVALTADPASQSEHLLAALTGTRGTLYLTAARSRRSVERTLESTREGAVTPTVRRVGGDARFEDATELIDKLPEGANLVIDSMNAFERGDRERYLEFLSGLVDRVTETDGLAVCHCLEGGSTPTNRSVTTHLADVVVSLRTYSAGVGTGIEHTLSIPKVRTERAAVETVALELDTDRDYEREREPSSARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P482</accession>
    <name>A0A3N6P482_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90175">
        <property type="protein sequence ID" value="RQG90175"/>
        <property type="gene ID" value="EA462_09305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="247" mass="26098" checksum="F3EF7E47B0141CE0" modified="2019-02-13" version="1">MAMDGRTCVVTGSARGIGRGIAQHLGERGANVVINYRSSEEAALEAVDAIETAGGSAVTARADVADRDDVEAMRSVCHDAFGPIDVLVNNAGITADTQFTDMTREEWDRVMDVNLGGMFNCTQTFYDDIWNADEGRLINISSVVGKQGNFGQANYAAAKSGMFGFTRTIALELAQGGSTANCVAPGFTRTDMLEGVPETVLDRIIAGIPLARLADVEDVAAVVRFLASEDSSYVTGEVIDVNGGMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4S4</accession>
    <name>A0A3N6P4S4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92989">
        <property type="protein sequence ID" value="RQG92989"/>
        <property type="gene ID" value="EA462_01895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01571">
        <property type="entry name" value="NAPRTase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035809">
        <property type="entry name" value="NAPRTase_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_C" evidence="2">
        <location>
            <begin position="115"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="40769" checksum="E62A849BD6AAA563" modified="2019-02-13" version="1">MSNPFGIVPSEAILEGTATDAYFERTRETLEYAGRNPTVVAEVTADQFPTGSFEVFTGVHDVATLFEGRSVDVDALSDGQLFDGGPVLRIEGSYLEFAELETSLLGFLSQPSGFATAALEARLAAPDCSIFSFGARHVHPSIASTVERAALVAGLDGFSHVAAGKILGRAAGGTMPHALLFCFGEGNQADAWEAFDEAVPADVPRIALADTFWDEVSESLLAAETLGDRLDGVRLDTTGSRRGDFRHIAREVRWELDARGYDDVEIFCSGGLDPDAVRSLRDVADGFGVGSHITGADSVDFSLDIVEIEGEPISKRGKLSGVKDVYRTGDGGHHVALASEPGPDEGRPLLEALVRDGEVVREFDLEAARERCLSDADVVGFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4T7</accession>
    <name>A0A3N6P4T7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type I-D CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cas3</name>
        <name evidence="4" type="ORF">EA462_02010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93009">
        <property type="protein sequence ID" value="RQG93009"/>
        <property type="gene ID" value="EA462_02010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017575">
        <property type="entry name" value="CRISPR-assoc_helicase_CYANO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03158">
        <property type="entry name" value="cas3_cyano"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="40"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="717" mass="80967" checksum="B6C94E4A8AB650EC" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P632</accession>
    <name>A0A3N6P632_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NOP58 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91175">
        <property type="protein sequence ID" value="RQG91175"/>
        <property type="gene ID" value="EA462_04065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D RNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="PTHR10894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="SSF89124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="1">
        <location>
            <begin position="177"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="305" mass="32520" checksum="D86C1A9B14273743" modified="2019-02-13" version="1">MNESPSADAGWFVDVDPDRADLESAVAAIREGETSTPREWPALAVEAGFVDDEPAYYDALKNATTEATRATVTEREAADDRQLVHAVRAMDDCDRTANELAERLAEWGGSVDSESGTGVEYARTLVDRSGRNSTDTVPSPDFGPDERPIHSLAARVTDLADEAEDLRRFVERRTPVVAPNLATLAGPVLAARLISLAGGLEPLAKKPSGTIQVLGAEDALFAHLRGHAPSPKHGIIYVHDAVRGTHPDHRGSAARALAGKLAIAARVDHYSGEPRPDLEAELNERIEAIQARTADADANGGDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6G6</accession>
    <name>A0A3N6P6G6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91375">
        <property type="protein sequence ID" value="RQG91375"/>
        <property type="gene ID" value="EA462_05205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="184" mass="20619" checksum="223B61D0C1D52FF3" modified="2019-02-13" version="1">MTTEGDSPTNDPVWAEVVADAGAITEEYRDRDWDVVVLEPADISPVEDGDRTGFDVVVSDAEYDLVETLVEGDDGSFTDADVYYRPSDGSDRRFALVLERDEASETAVCIPLTYSISSARSVLEGALLDEELLVHVRTLRSDTDDDDHEDRSKQWVTFSHDDPSLFLEESDVRDWDESETEDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P927</accession>
    <name>A0A3N6P927_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_00380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92725">
        <property type="protein sequence ID" value="RQG92725"/>
        <property type="gene ID" value="EA462_00380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="241"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="360"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="585" mass="62785" checksum="6DD3C6799651693C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9J6</accession>
    <name>A0A3N6P9J6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92905">
        <property type="protein sequence ID" value="RQG92905"/>
        <property type="gene ID" value="EA462_01400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="226" mass="24679" checksum="A45C873AFF9F6CA3" modified="2019-02-13" version="1">MGRVDRVSESDAEREQALQCKNQRLEQFASVVSHDLRNPLNVATGRLELARETGATEHFEEVANAHERMESLIDTLLALARDGEEVGTTEPVDLATLTEACWSVVATTDAGLVLETEQSIDANPRRLRQLLENLIRNAIEHGGEGVTVTVGELEDESGFYVADDGPGISTDESEKVFESGYSTTANGTGLGLTIVRDVVEEHGWSIEISERNPRGSKFVISDVNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9R4</accession>
    <name>A0A3N6P9R4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93015">
        <property type="protein sequence ID" value="RQG93015"/>
        <property type="gene ID" value="EA462_02040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="65" mass="7261" checksum="1F75CB16FD8C1B72" modified="2019-02-13" version="1">MECCNCNSVGRLEKYQLVLRGEDTLEMTITLCEECVIDFRATDWITVRGGSERATGRSGVEGQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9S3</accession>
    <name>A0A3N6P9S3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ORF">EA462_02090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93025">
        <property type="protein sequence ID" value="RQG93025"/>
        <property type="gene ID" value="EA462_02090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="100"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG93025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="330" mass="35386" checksum="6018C454FDDD6FCF" modified="2019-02-13" version="1">MSTETTPGPDITGGAARGDLEANRRARRLLFGCATITVVTTLAIFFVLIDNAVSYFFGARATEILLGASLERTVTFTEFFTGTRWAPDHATPGHGVLPVVFGTIAITVGAAFVAIPIGTATAIYLSEYASDGVRRKLKPTLEILAGIPTIVYGYFAIAFINPVVLSPIAETLFGINIGRYSMLSGMLVVGIMTIPMVSSISEDAMSAVPDDLRNGAYALGATRFDVSTRIVLPASISGVFASYILAVSRAIGETMAVSLAAGFNANITANPFDEIMTMTAYMVQMARGTTAVGTVEYQSLFAVGLLLFVMTLTMNLLNDWFKRRFQEEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA33</accession>
    <name>A0A3N6PA33_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93195">
        <property type="protein sequence ID" value="RQG93195"/>
        <property type="gene ID" value="EA462_03065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="28190" checksum="B6D9C8398869DFE0" modified="2019-02-13" version="1">MPTATNGDVSLYYDRTSAGDPHAEQVVFVSEAGLGGWLWGWQHAGLAGPFETVVWDLRGTGRSDSPPGPYSLEALVSDLEAVLIDCEIHTAHLVGCGLGGAIALVAARSSSRIETLTLFGTAARGDEYDLEPLFAPSDDRAAIRESLETALSADFREDQPDMFEGIVDWRADGDADRAGWEAQLAALEGFDASDWLIEVTQLTLVCHGGEDDLVSPAAGRDLADGLPRGEFVSLEDMGHLAFVERSRTINDRIAGMLEDESPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHK5</accession>
    <name>A0A3N6LHK5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redox-regulated ATPase YchF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ychF</name>
        <name evidence="3" type="ORF">EA462_17230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86210">
        <property type="protein sequence ID" value="RQG86210"/>
        <property type="gene ID" value="EA462_17230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="MMR_HSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="MMR_HSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="2"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="392" mass="42710" checksum="2BAE85EF78AEF196" modified="2019-02-13" version="1">MLSIALAGKPNAGKSTFYTAATMADVDVANYPFTTIDANRGVSYVRTRCPCLEREERCNADDCADGKRYVPIELLDVAGLVPGAHEGKGLGNQFLDELTNADVIVNVVDASGGTNEKGEPIDIGAHDPLEDIDFVEEEMDLWLAGIVERNWESVERKSRSPDFDIDDVLADMLSGFGASPTQIATVLRDLEYPEDPIQWDDEHREALARDVRRRTKPIVVAANKIDIAPQENVERLLDLDKPVIPTTAEGELALRRATENDLAAYDPGDRSVAIGDDVTDVQREALEDLGETMAEWDGTGVQSALDYAVYELLDHVTAYPVEDAAKWSDGSGNVLPDAFLLPTSSTPVDLAYAVHSDIGDGYLHAVNAKSGREVSDEYELEEGDVIKIVSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHT9</accession>
    <name>A0A3N6LHT9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86774">
        <property type="protein sequence ID" value="RQG86774"/>
        <property type="gene ID" value="EA462_16705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="402" mass="44135" checksum="8A9F3AB4A0B99F5A" modified="2019-02-13" version="1">MEIDIRELETYQELAHDGARSAAESLSQLTGISTRVQVTDVSLMSSSDLEYEFIGSEFAGVNIDLSGEIGGEVLLAFDEQGRAAITDRLVPADDPEKKKSSIKEVGNIMTSGFVDGWANYLEAKIKSSPPTYIQGTGTDVLPTSAIEEDRHLFVFRSRVEASQDSRSDPIDFRILLVPDSKSLERSLEPQTDKIVSLEKLEVFNDMTKEGAQKAATNITSMTGIETTVNISRLSLIPIEDIPTEVGSKRFVGTVMEFRGKFSGYLIILFDQPSGRAVVDSLVPMETDEQWGDIEQGALKELGNIMTSGFIDGWANVLNAEIKHSPPNFVADTGSGILTPITTQIAKTDDHAFLLDSSIQTNSDRVFTCQMLALPRRDELEQALDDLLIENSGNTRIDPDDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHX3</accession>
    <name>A0A3N6LHX3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86659">
        <property type="protein sequence ID" value="RQG86659"/>
        <property type="gene ID" value="EA462_16070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="218" mass="24210" checksum="E6DE6D08513F77EC" modified="2019-02-13" version="1">MSTEILPDVYDITVEETDGRRTRAFLRTRDVPTLIDTGFAETTDALFTELDDLGIAPRRLVITHGDSDHIGGFDDVVERYDVETWVPEQTTVDTRVRPDNRYEHGDSIGSFEAVHTPGHQPDNYALVDEEAGILVAGDALFGADLRGLPDGYLVPPPALYSENVNRAEQSLETLLEYDFDAVLVFHGSSVTKDAYDRLEAFVDFPGKPDWATYLDSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIV4</accession>
    <name>A0A3N6LIV4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87916">
        <property type="protein sequence ID" value="RQG87916"/>
        <property type="gene ID" value="EA462_13720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005064">
        <property type="entry name" value="BUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042100">
        <property type="entry name" value="Bug_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42928">
        <property type="entry name" value="PTHR42928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03401">
        <property type="entry name" value="TctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="348" mass="37551" checksum="DC26667A5A0A7048" modified="2019-02-13" version="1">MVHDINQLGADSATSRRKVLALSGSAMAAGVAGCLGDDDGDDDDEEYPTGDIDVIIPFDTGTGFDTFVRGVIEFLPGHLPNEVDVIPDNQGPAPEGTAAIYNAEPDGYEIGASMLLGMSVQELMLDAPFSIAEMTALPRIHADRAILAANTDTPYETVDDLQTTDEDLRWAVVGGTDSHYQAVITADEMGIPADIVPYDGAPDAIASTLRGETEITAFSASSTPMADGLTQGDLRPVMIYNDGPLDYLPYTQELDIADTTHDLGYSELDITSVQRVFFAPPDLPDDIHGVLEDALMDTMESDEMQEWADEDEGRFVDPAPSDVIADEIDMIHDLINEHEDTIQEHLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ13</accession>
    <name>A0A3N6LJ13_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88026">
        <property type="protein sequence ID" value="RQG88026"/>
        <property type="gene ID" value="EA462_14315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="67" mass="7609" checksum="182EC76EA444C7C7" modified="2019-02-13" version="1">MRFDPPLFVSGEILLVGVYNPVPGHFRDIESNVNRFCEVKSVPLEECLRRVEEPFGMFVDVVLSSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJF6</accession>
    <name>A0A3N6LJF6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH bat-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88061">
        <property type="protein sequence ID" value="RQG88061"/>
        <property type="gene ID" value="EA462_14525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="158"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="217" mass="25088" checksum="4119E51CC03BF06F" modified="2019-02-13" version="1">MTLYEATFRVAHESAYAELTEGRDLRLDMWCNDHCDMIRASGTDHDVLIDRLEAHVGIRDMYREDERLLLITNDCLRSHQEPLIEAYLSEHGCLLWPPQQYEHGQLLVRVLALTESSLSELYQQLVDDFPVTVESKLRRTHDVLDNIVDQSHSVTAGLTNRQTEALIAAHEYGFYEIPRDNTSEEIATHLDLSRRTFEEHLRRAEGKIVSEVLSEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJN0</accession>
    <name>A0A3N6LJN0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88933">
        <property type="protein sequence ID" value="RQG88933"/>
        <property type="gene ID" value="EA462_11100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="38"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="13022" checksum="8497839DF5CE734F" modified="2019-02-13" version="1">MSGKTPTGRLTPVENAAGRTVYYDEDQRTYHTWCDDDDYEPVSTALLAVVSSVIGTDPVELESLSDRVDPDALNAMVHHWRTGGSDGGGSISFTFSDCGITVLASGEIVIDPNRRQRSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJP6</accession>
    <name>A0A3N6LJP6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86164">
        <property type="protein sequence ID" value="RQG86164"/>
        <property type="gene ID" value="EA462_16980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="378" mass="41420" checksum="D6FF1941F05AEC21" modified="2019-02-13" version="1">MSVPGIVQSTLTDEDIAARVSLGGDDELFITPTRTIVYRAEGLLSDESVDEYPHDADRLTLSEGRRKTKFSLEYPLDGSYEFTVPSSKTDAVLHPVLAGVLNGNEITDPGETVVQTYRFSELTLIITSDRLVKHIGGAVWDDDYEEYHFGDVTNLSFEDGSVATQIVLEVGGRPQRIKAPNEEANDLRERLKRALFDYHDVKSLEQLNEEVGDDGDDDAPTDSGMDFGGGIDPLDTSSSEDGEGDTVEEADGREAAVPDSIDAQPDRPDDDERTRGQSSSSASAATVPSDPNESASDSSEGQRVATVETGDVFENPDDSIETRDADRKKVRSTTGDVSRSDLLERIETLEESLARQNDLLEQQQETIEQLIVELRQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJR8</accession>
    <name>A0A3N6LJR8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88993">
        <property type="protein sequence ID" value="RQG88993"/>
        <property type="gene ID" value="EA462_11440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="14"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="171"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="618" mass="68776" checksum="58A4D8A3ABF95898" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJV8</accession>
    <name>A0A3N6LJV8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88848">
        <property type="protein sequence ID" value="RQG88848"/>
        <property type="gene ID" value="EA462_10635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="62" mass="7426" checksum="972EF07CBB700DE8" modified="2019-02-13" version="1">MPMIERFIRLMVWWFRKWYPIFRLVGEKTGREEYVETAIEVSEENFQNTAEAIGIELEGIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKE8</accession>
    <name>A0A3N6LKE8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PRC-barrel domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89108">
        <property type="protein sequence ID" value="RQG89108"/>
        <property type="gene ID" value="EA462_12100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="81" mass="8640" checksum="55A8ECDE224FF329" modified="2019-02-13" version="1">MTENTLEKSDEGKRVLNVDGTEVGRIVAVEGGRGYVVPDPGLVSTIRAKLGWGTVPEDGHPLDEGSIEEITDDAIHLRGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM78</accession>
    <name>A0A3N6LM78_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_09295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90173">
        <property type="protein sequence ID" value="RQG90173"/>
        <property type="gene ID" value="EA462_09295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="29"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="385" mass="42025" checksum="C52FA9472BB583FB" modified="2019-02-13" version="1">MTIELSERVKTVPPSGIRRFFEIAEERDDVISLGVGEPDFSTPWAARDAAIASLEQGKTSYTANRGKRELRDAISTYVSDRFDLEYDPDEQIIVTAGASEAVDLAFRALVDPGETVAIAQPAYISYEPGVIFAGGEVLSVPTSKGDDFRLTVGALEEAGAADADLLVLCYPNNPTGAIMREDDLEPIAAFAREHGLTVLSDEIYAELTYDGEHVSIATLPGMRERTVVFNGFSKAHAMTGLRLGYALGPTDVIGAMNRIHQYTMLSAPTTAQYAALEALESCHDDVREMVDQYDRRRRFVLSRFREIGMDVFEAKGAFYCFPEVPAGVSATEFAEEVLHEQGVAVVPGDVFGEGGTGHLRVSYATGLEELREALARIETFVEEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNN0</accession>
    <name>A0A3N6LNN0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_12950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87777">
        <property type="protein sequence ID" value="RQG87777"/>
        <property type="gene ID" value="EA462_12950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="42"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="382"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="419"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG87777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="645" mass="71736" checksum="17D972B8E50A0074" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNU6</accession>
    <name>A0A3N6LNU6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87857">
        <property type="protein sequence ID" value="RQG87857"/>
        <property type="gene ID" value="EA462_13410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="1">
        <location>
            <begin position="130"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="340" mass="37475" checksum="C259B7DE667DEF26" modified="2019-02-13" version="1">MPSHRRSFMKKVAIGASAGISGITAGCLGDNDDTELQVGIVDPLTEPVSLFGIDEIADTAGENMGAEYELTVNAAEGSPQVINQLSAGELQIGNVAYASFPRSVAQEAVPGGITGIVSEARDAHPDYKPWEILTLEDSDISEPEDLEGSDFGVNAVGTGVHAICELGLREFGLNPDEDIDWVEIEFPAIGSALRDGRIDAGIFVPVFSHAEVAEGGVELVFDSTDVWDEQYDFTFLAARNEFLDDNSDTVEYFLEDYTNLLEYIYDPDNRDDVVSLASDEFDVPEELLDMYYLTEEDFYRPQDGRLDIPRLQEVIDRLYESELIEDNINVEDNATNEYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNW1</accession>
    <name>A0A3N6LNW1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_03550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91088">
        <property type="protein sequence ID" value="RQG91088"/>
        <property type="gene ID" value="EA462_03550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039263">
        <property type="entry name" value="GTPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="PTHR43721:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="141"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="551" mass="59761" checksum="13F76B3F780DDED4" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNY5</accession>
    <name>A0A3N6LNY5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tricarboxylic transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87917">
        <property type="protein sequence ID" value="RQG87917"/>
        <property type="gene ID" value="EA462_13725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01970">
        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="494" mass="51211" checksum="02F6EB9A3EAB6E7D" modified="2019-02-13" version="1">MSEILSAAVQAAEVLFTWPTIGFLILGTLIGLIFGAIPGLGGAVAIALLIPLTWGVDTSAAMVLFAATLGGATFGGSISAILINTPGTPPNAATLLDGFPLTRQGRSGEALATSATASALGAVFGVIVLLASLPVAREIVLAFGSPEFFWLGVVGVSVIATISRGSTLKGMIAGGFGFMLSFIGYQGATAEYRFSLGTTFLWDGLELIVVLIGIFAVGEAINLATEEGKISQVKTKANRSDIVQGIKNPFKHWFLFLRSSVIGSLVGMIPGAGGALATFISYAQAVQTSDNAEKFGDGDVRGVIAAEAANDSSDGGALIPTVVFGIPGSVATAVLLGAFIFHGLSPGQQLLNDNLDILLLIIFALVISNVLTSLIGVVSANQVAKITQIDTNLLIAPILVISFVGAFGLRTHIGDVGVVAIFGLIGYLMLRFGYSRIAFVIGIILGPIIESSFLQSLSVSGGSYMIFFERPLSIFLIVILVLNLTAPFIRRTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNY6</accession>
    <name>A0A3N6LNY6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_03735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91118">
        <property type="protein sequence ID" value="RQG91118"/>
        <property type="gene ID" value="EA462_03735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1023" mass="110768" checksum="DC789BC49224F7A7" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP13</accession>
    <name>A0A3N6LP13_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87967">
        <property type="protein sequence ID" value="RQG87967"/>
        <property type="gene ID" value="EA462_14000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="43"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="186" mass="20351" checksum="7C575D29105F3DA4" modified="2019-02-13" version="1">MGHHTFDPSRADKLERPGRRFRFLSAEELRWALDLDASDRVADLGSGTGFYTDVIASQADTVYAVDLQPEMHEYYREKGVPESVELVTTGVGDLPFDDGTIDVAFSTMTYHEFASADALAEIHRVLESGGRFVIVDWAATGPGESGPPLAERYGADEIADALREAEFSIEHVAVRSETVLVIATAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP16</accession>
    <name>A0A3N6LP16_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89807">
        <property type="protein sequence ID" value="RQG89807"/>
        <property type="gene ID" value="EA462_07245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="30"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="276" mass="30892" checksum="0B5290500F233C98" modified="2019-02-13" version="1">MTEIRSDWGDWLIRDVEAAQPNGLAVWYLGCNGFILKGSDGTTVFIDPYVGLGDPPRTVRMIPVPFDPDDVTDADAVLATHEHTDHVHGPTQAPILERTGATLYAPDESLSVVREDEEWLTEWNVDEGQLSEVTEGKTVEIGEFTVHVEHANDSDASHPVSYVIEHDAGTFFHGGDTKPSDEFERIGREYDIDLGVLAFGTVGMVLDRRTRWYNDENQIIEAATALEIDRLLPSHWDMWRGLTSDPKTLHHHAKSFEYPSRLEITEIGDRVDITGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPB8</accession>
    <name>A0A3N6LPB8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89967">
        <property type="protein sequence ID" value="RQG89967"/>
        <property type="gene ID" value="EA462_08140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="143" mass="15444" checksum="19FC97DA8BC85B1E" modified="2019-02-13" version="1">MYQVLLPVDSNEDRAIDAANVVRSLPGPPGDVHVTILNVQKELDVSDGDGNARSEDWYDETDFPPAIDAVKRHLEDDGFVVETRREHTDPAEGIITVAAEIGADQIVMSGRKRTPAGKVLFGSVTQSVLLNAETSVTAVMTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPH3</accession>
    <name>A0A3N6LPH3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amphi-Trp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91368">
        <property type="protein sequence ID" value="RQG91368"/>
        <property type="gene ID" value="EA462_05170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027598">
        <property type="entry name" value="Amphi-Trp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20068">
        <property type="entry name" value="Amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04354">
        <property type="entry name" value="amphi-Trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amphi-Trp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="93" mass="10243" checksum="545E2722C75A0706" modified="2019-02-13" version="1">MPEEVLFKFEREMNQADIADYLRAVADNLESGEDLTIEAGGESVTMSPPARPTFEIKAERETSSSGGAGELSIEFELEWDENGDRSSGELNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ26</accession>
    <name>A0A3N6LQ26_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90327">
        <property type="protein sequence ID" value="RQG90327"/>
        <property type="gene ID" value="EA462_10155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="307" mass="32227" checksum="5E11D4D0B74A4F34" modified="2019-02-13" version="1">MTEGTTDGFEDRSDSVGIVDHSRCRPTRATAADRARPLRLLTDGGQAQVEEDEQNHDQERESEGENGGDTDGEDDDESADETAEGAEDDGSERDDLEGESTGDAEDGMDDSHVEDAEDVYEGDDASGVLHLDLDGLFLDLLGLEVNLNPVTLDVSARPGENNLLGNLLSAVTGLLDGTASMMDRLTSLLGTPKKLLGKITGTLRETAATLLGKPRDVVRGLTGGSEDGDSEDDSDGEDDTTGGALSSVTSWITSRLAGLVPSLPVEELLATVIREIIRGVIDQLEPPADESDGESETGADQQAEAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ39</accession>
    <name>A0A3N6LQ39_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89044">
        <property type="protein sequence ID" value="RQG89044"/>
        <property type="gene ID" value="EA462_11735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="626" mass="63174" checksum="81EBA8813B24EC13" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ69</accession>
    <name>A0A3N6LQ69_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CinA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90387">
        <property type="protein sequence ID" value="RQG90387"/>
        <property type="gene ID" value="EA462_09790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="11"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="175" mass="18295" checksum="769D9A3E1B4533D4" modified="2019-02-13" version="1">MNDDIDRGLPMAVADALRATDETLAVAESCTGGLIGAAITAVPGASEYFEAGLTTYAYGAKRRLLGVSREALDEHGAVSAPVAREMARGVRDVTDVSWGVSTTGVAGPTGGTDETPVGTVYIGIAYAGPWDSESSFATTARYEFDGDRAAVRAKTADRALEDLLESIEDREKMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQE6</accession>
    <name>A0A3N6LQE6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_12520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89184">
        <property type="protein sequence ID" value="RQG89184"/>
        <property type="gene ID" value="EA462_12520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="24"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="422" mass="44687" checksum="C82A2BB383868E22" modified="2019-02-13" version="1">MSGNATAAPVTLSDVERARERLDGVVHRTPLETSRTFAELTGATSVGLKLENLQRTGSFKIRGAYNRMAQLSDSERDAGVIASSAGNHAQGVALAGDLLRIETTIVVPEVTPAAKIEATRGYGAEVVVEGDIYERSYEYALERAKNTGETFVHPFDDEAIVAGQGTIGLELVEQYPDLDTVLVSIGGGGLISGIGTALEARDSDRRVIGVQPAGALHAKPSLERDEIVELEDVDTVAEGIADTRLLETTFAVAREVVDDVVGVTDREIATAVTLLAERAKTVSEGAGAAPLAAALSETTDLDLAGERVAVLVSGGNVDLTEHAELTRTGLECLGRYTELRLEIAGWPSTVGDVVAVIESQGGELDVLERARRRGLDHPNRVPMTIAFEGSGPEHLERIRESLSDLSGVTVLEDETASTGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS17</accession>
    <name>A0A3N6LS17_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Poly(R)-hydroxyalkanoic acid synthase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91287">
        <property type="protein sequence ID" value="RQG91287"/>
        <property type="gene ID" value="EA462_04685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="181" mass="20881" checksum="20495C991A34AAD0" modified="2019-02-13" version="1">MEHENPQTQHWNAFVEQWNEQFIDAFEDNVETQAQFVESWSETVAELSEDETTSEGLEGYAKAYETWMNASQQMVERMNDTLEGEDVEIEEFRDVWLNTANDAFKDVMSTTAFAKMTGETVGDVLELKQDADEASQETLRTLGFATEEDLLEVGDRLVELERRQQAVEGKLDRILEHVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSD9</accession>
    <name>A0A3N6LSD9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_00985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92833">
        <property type="protein sequence ID" value="RQG92833"/>
        <property type="gene ID" value="EA462_00985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="39"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="150"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="360" mass="41640" checksum="3604ED7E443615DF" modified="2019-02-13" version="1">MGLSAGSHEGQSVQCPVYEQARQNPEWQDLLSGPVCTEPKCGHLINRVVNKAGYWSDSTIRKYCYAGSHYIIYLHDQGKTTCDAEYEDVERFFAKLSKRKLRKNTYMNYRTAINHIYTSIALSPDHHSYLSAQKINEWLNLEELPTRKQLERESLSEEEVEKLFEELTCFRDRLMAQSAIEWGGRNESLRALKTSDVNLGTQIVRLKNTKSGGTYPVPISDKLTMLLRHWINVERKAYLVSSENDYLFPSRRGGSLSGTSFSEMVREAAEEAGIQKVIGTIKHTERQKEAFGKEKRNFYRVTPHALRHTFNELLRARGIPREVRSDALDHSSTDVTKEFYEHSTENYHSQIRRHFSDMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSI0</accession>
    <name>A0A3N6LSI0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metal ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_09685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90244">
        <property type="protein sequence ID" value="RQG90244"/>
        <property type="gene ID" value="EA462_09685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="366" mass="38452" checksum="71D6BC3623F921D6" modified="2019-02-13" version="1">MSGPNEHATESTTVSEPNSHASADRWRALEVVGVSIVGVLGALMIGVITLDWLRHYPSLGNGPVLLFEQLRIAGMWADHYLGTDVFAHPFMWRSIATGVLIGIVAPLVGTYLVHRQMALIGETLAHTAFAGVAIGLLVIAVTGFEGSLLLVALVVSVIGALGVQWLTERTSTFGDVPIAIMLTGSFAIGTLLISWGRGFMSVSIEIEGFLFGSLSVVSPSGARMMAVLSVAVVAVVIYTYKQLLFITFDEQAARVAQFNVSGYNTLLVVMTAVVVVGAMQVLGVILVAGMLVIPVAAATQIARSFRETLYLSILFGQLSIGGGFAFAISQSLPSGGSIILVAIAIYLVSIFVSLLAGRSSAAISMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSP7</accession>
    <name>A0A3N6LSP7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90344">
        <property type="protein sequence ID" value="RQG90344"/>
        <property type="gene ID" value="EA462_06975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="70" mass="7460" checksum="815B292A1F8DAB36" modified="2019-02-13" version="1">MDRSGFVRLAVVAIGLVIASFFVRGFGQLVVGRGSAEMLQAPILFAGFGLLVYLFVRATLDAIGLWSIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT40</accession>
    <name>A0A3N6LT40_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="3 5">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argF</name>
        <name evidence="9" type="ORF">EA462_03030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 5"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93188">
        <property type="protein sequence ID" value="RQG93188"/>
        <property type="gene ID" value="EA462_03030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="171"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="73"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="281"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG93188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="322" mass="34998" checksum="691459921AB7B2D8" modified="2019-02-13" version="1">MTDTDTDTETTDSSAVDTGDAELRHFLEVDDLSREELLAVLDRAAAYKGAQARGDDHEDLEGQTLGMIFQKPSTRTRVSFETGMTHLGGHAIFLGADDIQLGRGEPLKDTSRTLSRYVDAVMGRVFKHDNIEVLAQYASVPIVNGLTDDAHPCQTLADLQTIREHEDGFDDVSAAWIGDGNNVAQSFAIGAALTGIDLTIATPEGYGIDDAVLERARSLGGEPTVTTDPIDAVADADVVYTDVWISMGQEDERDVRMDDFEGFQVNDGLLAHAPDASVMHCLPAHRGEEITDDVVEGDRSIVFDQAENRLHAQKALLSWLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUX6</accession>
    <name>A0A3N6LUX6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91414">
        <property type="protein sequence ID" value="RQG91414"/>
        <property type="gene ID" value="EA462_05430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="174" mass="19304" checksum="329D5D8096903EAC" modified="2019-02-13" version="1">METLEITDEQYEVIQQLREEMSESVVGKYGFVREQDVVQFLLDNLDEETQLADEVDLAPDDSTAAVDADGPVESGSSEREEVTFDETARAATDSSSDSSSDNEDENAGDEDADDGGNADDDDLLNEMMSLLETHDDKWEESSSADYRYTVTLPDGSSEDVQTKDDVRALLFKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV73</accession>
    <name>A0A3N6LV73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TrmB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91564">
        <property type="protein sequence ID" value="RQG91564"/>
        <property type="gene ID" value="EA462_06310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="279" mass="30795" checksum="69ABBB33D9F18565" modified="2019-02-13" version="1">MDELTDQQQAVELLQQLGLKEYEARAFVALSRLPRGTAKDISEISEVPRTRVYDAIRVLETKGLVEVQHSNPQQFRSVSFAEATETLRDEYESRTELLHETLQDLEPANFDSDAGTAHEVWALSGNVPITNRAHQLLDEAENELVFVIGHDSVVTDTLFDSLKAAQQRGVTIIVGTISGTLRERVQDRLPNAEVFVSGLEWLSGAALTDDETEISRILLVDRSTILVSSFHEAETGERSHEQAVFGRGFDNGLVAIVRRLMATGLVPLDDPGTAGSDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVG3</accession>
    <name>A0A3N6LVG3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nmad3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91684">
        <property type="protein sequence ID" value="RQG91684"/>
        <property type="gene ID" value="EA462_03625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041135">
        <property type="entry name" value="Nmad3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18754">
        <property type="entry name" value="Nmad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nmad3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="273" mass="30456" checksum="D3BFB75A7A2695BC" modified="2019-02-13" version="1">MTVVLAGVGADSTNLGALGPLYDDGRFEYVPIPEKTRETSEVETLGSWTLRADDRVAADLTTRIDPQPVRGGVDSVTGDDLESWPLHRDPNFEARTYGEHRTSGYVTRLRSLESGDVVGFYAGLRRPNGERAHRYLIGYFTVDRVDVIGSETPPAERKALFERHAENAHSKRARGDTPYLAEKQIVIVDGREPGGLFDRYPIRLSEYYVAPGNQRPQYYLREDLAAAWNVREGKSNMMFKPAYRCSLSGEEFRSNVGTPGDRSVAHGKVDTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVW3</accession>
    <name>A0A3N6LVW3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92927">
        <property type="protein sequence ID" value="RQG92927"/>
        <property type="gene ID" value="EA462_01515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="161" mass="16856" checksum="A932833A6E1D60D3" modified="2019-02-13" version="1">MVSRRTMLAISGLGIVATSGCLGEDGGDGESGSDVAARNPEAPLVTTTDDGNDELVLATYGDVVEVSTVDYNDQQGRYYVPIGLTEEATDSFVDDLESIGAFDAPSERELAIHAADEVVDTPVIGRSLADAMQAGEWDGSLQIGSADEGTLLDLRSELDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LW69</accession>
    <name>A0A3N6LW69_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent F420 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">npdG</name>
        <name evidence="2" type="ORF">EA462_02345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93067">
        <property type="protein sequence ID" value="RQG93067"/>
        <property type="gene ID" value="EA462_02345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="222" mass="23244" checksum="736EE25D84ADFC08" modified="2019-02-13" version="1">MRIALLGGTGDIGEGLALRFARDTDHEILIGSRDPEKAREAVASYEAELEARGADADLNGFGNEMAADRADVAILSVPPYYAGDTVEAIDGSLDAETVLVTPAVGMNGDEDGMHYHPPGVGSVSELVAQRASDDVPVVGAYHNLAAGKLGDLDVEFDLDTLVVGDDTDAKATVTDLTNEIDGLRALDAGPLANAAEVESVTPLVINIAKYNDEMHDVGVKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY39</accession>
    <name>A0A3N6LY39_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92754">
        <property type="protein sequence ID" value="RQG92754"/>
        <property type="gene ID" value="EA462_00540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="310" mass="34016" checksum="A434A2443D954D96" modified="2019-02-13" version="1">MSEHTTTRDESGSTRRSFSNLSPSVRTIASDAIPTDDRSIPVALCRLGTELRLESDRPHPKSHRSTAPVVDAIRSLEGYVVVRRELLETERYDREAMRDTAVLASDFLHAKAYESIAETPLTRRRLLELYRIATDGSTAISTQFLARVANESAGGVEHDGTPFETLSETAAALGTTAAGTSDETRAAFERYGRELTAACHRHPLSIERSQRVAVEILAGSTSTEPTDGRERVTDDTARLTDDGDRPNGEGDRLAASSSLEQHLASARTSLDRLRELNRSASVSSAQNQPILSRLERATRIPFENVLEIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY50</accession>
    <name>A0A3N6LY50_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87021">
        <property type="protein sequence ID" value="RQG87021"/>
        <property type="gene ID" value="EA462_15375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="180" mass="19873" checksum="F9BC782357E92822" modified="2019-02-13" version="1">MSGESSSETYRINGDQIPVEQVDEFDGDRILSTDVTRAVNEGFDFTDIWRHASVEVENDGETFTATVVACEIEHGMGAIRLTDIEENKIEVAGHEVYATQKSILPCPVCESSREVYYLGSRNSLTAGDEPRSYTVSGWVCPECESTLEVTDEDLRNGSGNVAWADVIVRSRQLGGERNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY58</accession>
    <name>A0A3N6LY58_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87031">
        <property type="protein sequence ID" value="RQG87031"/>
        <property type="gene ID" value="EA462_15430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="143" mass="15171" checksum="F4D6D043A6E03589" modified="2019-02-13" version="1">MATSRSLAFGSGTGSNEIDPIDIIALMVLPISASMIFQVFSFQINVFGEYDFTEPIWTVGGADISLALLITVAAVAWVLITNIVNAETDHGPYELGAIVVAILLPVAYVFVPAVESAVMWNDLMQLAALLYVSAATVVVSYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYC0</accession>
    <name>A0A3N6LYC0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86712">
        <property type="protein sequence ID" value="RQG86712"/>
        <property type="gene ID" value="EA462_16380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="361" mass="41140" checksum="7C0CAAC4EEC7AF1D" modified="2019-02-13" version="1">MGRIDKYMAVGLSPTVWGAEERSDIQKNLDHIHENLSAATWLSGTDLPVKLAVIPEGALQGFTDEVFDMDHQTYRDEIAVDIPGKESDTLGEYAKEFGIYIVASAKEKAPEYDDRFYNTAFVISPDGELILKHRKNTPLLPVERSVTPHDMWDDWVEEHGKDLDSFFPVVDTDIGRIGISLAIEGAYPEYVRGLAMNGAEVVCRIACPEPMVANNAWEIQNKARALDNNVYFMAPNLGTYYLTQDKEEPIDTFGGGSMLVDHKGRTISEHDYGAGSSYCAGVIDIEGLREFRTRSPQMNWIKDLRTELCEVIYDRELYPKNLWLDDLPVNHEEYNEEVTQKQIELMVEKDIYVPPYWEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYG3</accession>
    <name>A0A3N6LYG3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fla operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86772">
        <property type="protein sequence ID" value="RQG86772"/>
        <property type="gene ID" value="EA462_16695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007381">
        <property type="entry name" value="CheF1/F2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42201">
        <property type="entry name" value="PTHR42201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04283">
        <property type="entry name" value="CheF-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="291" mass="32140" checksum="664D5DD994AAC85A" modified="2019-02-13" version="1">MDEDIVADFTGRFFLKRTGDDVPSSGRIIMTRKRLVLATNDNRTTISLSRVVDVNVGSVPKHVRRFFDDTVTVGYEADGSVRSAVIESNSDTVTTFVAILFRCLLNDQRVSVSHPAKVGGRIRNTNVVEGKLRIKKRSIAVATKTGSFEIDVETVMDIKRTNKIGERSDRVTLAVKYIDTGSGLTKTSLLSPEKGKNVNLLARYLRLEFDELRDEVDQLELSNPEKRVLVSVHAAGGDIDFTNMLDGDPAYVTNVLNSVQRKELVVDGESGISLTPKGRIVVSQRIEDVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ66</accession>
    <name>A0A3N6LZ66_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93194">
        <property type="protein sequence ID" value="RQG93194"/>
        <property type="gene ID" value="EA462_03060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="199" mass="22817" checksum="00D5D25EEAD9FD93" modified="2019-02-13" version="1">MDDGNNRADGADFIDGTDPEALREEEQLQPTPEQHERLKDGLHGELFDDIRRADRRYLVIGRGSDAPGERRAAVCEQLDERLSAVAFRLEEFGFSGEEVDLWVPAFEILSEMASRIVAIVEDYDGGHVWELGYLYRYQTTVRNALWMLKRVYETESKRRERYDNGMAASHMAALEKAVSERVIGWESPDDLPRAVERVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M011</accession>
    <name>A0A3N6M011_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87844">
        <property type="protein sequence ID" value="RQG87844"/>
        <property type="gene ID" value="EA462_13330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="41"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="287" mass="31476" checksum="2D294A5DA6E8E18C" modified="2019-02-13" version="1">MVHSNWGTWFVNDEIEAVEPFGLTMWYIGGTGFVLRTPETTVYVDPYFGDGDPPNIVRMLPVPLDPADATECDAVLVTHEHLDHMHPPSYRPFVDDLGADVYATEACYDSPQYDGEIGVPDEKKHVVASGDSVRIDDLVVHVRGANDPAAIDEVSYVIEHESGTFFNGGDSRPDSEGFPAIADEFDIDAGALALGSVGNVSAPGGTEIERTRWYMDENQLIEAANQLELERLLPVHHDLWRGVGANPAVLGEHAASFEFPRTIESVSLGDRFDVDSPGRVQSRAIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1V8</accession>
    <name>A0A3N6M1V8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arginine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_11880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PdaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89071">
        <property type="protein sequence ID" value="RQG89071"/>
        <property type="gene ID" value="EA462_11880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016104">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016105">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase_sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002724">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438">
        <property type="entry name" value="PTHR40438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01862">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01170">
        <property type="entry name" value="Pyruvoyl-dependent_arginine_de"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56271">
        <property type="entry name" value="SSF56271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="166" mass="17037" checksum="6266AE2666611CE6" modified="2019-02-13" version="1">MSTIRVVWGSASAPTAMSSYDAALADAGVENYNLVSVSSVIPEEVAVEAVGTAPDLGPAGNRLTVVESRATTGPDTGSSASRVSAALAWARSLGDGPGLFYEAADETGSEDVEERVREGLAAGQELREWTFDEPRVAVESSEADPGTYTTAVVIAAYGGSVPIIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M293</accession>
    <name>A0A3N6M293_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89231">
        <property type="protein sequence ID" value="RQG89231"/>
        <property type="gene ID" value="EA462_12770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="148" mass="16143" checksum="B419E7525396F118" modified="2019-02-13" version="1">MSTTEPLGQRGRLLVVAVLIGTFVCLPLWFGSSRPSIGGVVSSGGSDQLTPVLEDAFPVDEWPGSREPWERYYMYGISGVAGIWVASRFVLGWRFDRERVAFVPRSDQCAPAGVFRRATVASESEREAETAGSAQEERNTTGRGIEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2R5</accession>
    <name>A0A3N6M2R5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufB</name>
        <name evidence="3" type="ORF">EA462_08930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90110">
        <property type="protein sequence ID" value="RQG90110"/>
        <property type="gene ID" value="EA462_08930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="137"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="476" mass="53016" checksum="1D3FB22A233D280C" modified="2019-02-13" version="1">MSSEQDHLKETDTEARFEFKKEQNAAVKSGKGLTEEVIRMISEDKDEPDWMLERRLRALKQYHNMPMPTDWPGQPDLTQLDIGEIVPYIRPDVDKREGVDDWTELPDEIKDTFDKLGIPEAEKNALSGVGAQYESEVVYQNMQDQWEEKGVVFMNMDRAVQEHPDLVKEHFMTTCVPPSDNKFAALHGAVWSGGSFVYVPEGVTVEMPVQAYFRMNSEGMGQFEHTLIIAEEGAEVHYIEGCSAPKYGSHNLHSGGVEVFVGEDAHVQYSTVQNWSKNTFNLNTKRAICEADGTMEWISGSMGSKATMLYPCTILKGRGSTDTHITIAFAGEGQDIDTGAKVYHNAPDTSSTIESKSISKDGGRTNYRGLVHIADGAENSSTAVECDALMFDNESTSDTMPYMEIEESKVDVAHEATVGKIGDEDIFYLQSRGLDDDDAKKMIVAGFIEPITEELPIEYAVELNRLIELEMEGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3C1</accession>
    <name>A0A3N6M3C1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_17140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86193">
        <property type="protein sequence ID" value="RQG86193"/>
        <property type="gene ID" value="EA462_17140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="77" mass="8932" checksum="4A82A66BC36EF0DD" modified="2019-02-13" version="1">MWVQELIYDIPASVFYFELLEPRVRAKAPIDERVVPNCNANRALHRSRPRLAAETRVTVTRSLGDREPNLERGRCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3W6</accession>
    <name>A0A3N6M3W6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89911">
        <property type="protein sequence ID" value="RQG89911"/>
        <property type="gene ID" value="EA462_07830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="66" mass="7451" checksum="4E38BAB2BBB14DC9" modified="2019-02-13" version="1">MATTNDVSNGMTEPCEVCERDTLHDVSVQLVTEGGEGKNARYSREPYRVRECLRCGNRDSQRMNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3X2</accession>
    <name>A0A3N6M3X2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">tRNA (cytidine(56)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="6 10">2.1.1.206</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">tRNA ribose 2'-O-methyltransferase aTrm56</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_07880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42968"/>
            <dbReference type="Rhea" id="RHEA-COMP:10308"/>
            <dbReference type="Rhea" id="RHEA-COMP:10309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.206"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the aTrm56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.206" evidence="6 10"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89921">
        <property type="protein sequence ID" value="RQG89921"/>
        <property type="gene ID" value="EA462_07880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00077">
        <property type="entry name" value="tRNA_methyltr_aTrm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002845">
        <property type="entry name" value="tRNA_mtfrase_aTrm56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197">
        <property type="entry name" value="PTHR42197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01994">
        <property type="entry name" value="Trm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016123">
        <property type="entry name" value="UCP016123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="10">
        <location>
            <begin position="114"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG89921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="209" mass="22883" checksum="45C81698A0DF01E5" modified="2019-02-13" version="1">MNDEPEVAVLRLGHRPGRDERMTTHVGLTARALGADRVLLPDNAGQSLETVVDITDRFGGPFEAELTGSPKAVIREWEGRVVHLTMYGERVQKVESDVRDAHRTVGEALLVVVGSEKVSFDVYEAADWNVGVTNQPHSEVAGLAVFLDRLFEGAELDREWEGADRRVVPMETGKRVEPAEDGERAANDDDSGSDDHAADDDHTANRTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M462</accession>
    <name>A0A3N6M462_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chorismate mutase</fullName>
            <ecNumber evidence="3">5.4.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90011">
        <property type="protein sequence ID" value="RQG90011"/>
        <property type="gene ID" value="EA462_08370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010950">
        <property type="entry name" value="Chorismate_mutase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01791">
        <property type="entry name" value="CM_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="107" mass="12316" checksum="01B90AD8C993911D" modified="2019-02-13" version="1">MTRDTETTENQIGDRTTDDMALDELREEIETIDREIVELIAQRTYVADTIAQVKEEEGLPTTDESQEQQVMDRAGSNAEQFDVDANLVKAIFRLLIELNKVEQRNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M471</accession>
    <name>A0A3N6M471_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90021">
        <property type="protein sequence ID" value="RQG90021"/>
        <property type="gene ID" value="EA462_08425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="81"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="198" mass="21750" checksum="2B79F9F2A904C411" modified="2019-02-13" version="1">MAESTPGSTDGTGRSGPTNADAGTDPNDRDLEWLSLDDGEEIVWADGPDRRTLVPAFVIGVPLAIVLIGILIIVGEYLRVTNTHYVVTDRALYRKSGVLSRDVKRIDHEKIQDISYSQSALGTVFDYGTVEVSTAGGSGVEMAFKSVPEPKAVQQLISELIDRDHREKTDDRSKDDVLEEILAELRSIRTTLEEPDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M499</accession>
    <name>A0A3N6M499_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_08605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90051">
        <property type="protein sequence ID" value="RQG90051"/>
        <property type="gene ID" value="EA462_08605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="15"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="347" mass="38965" checksum="791A2DC676EDB92D" modified="2019-02-13" version="1">MRPYRWRKPMIDPKIEVTDLKKHFKSNEDLFTRLFGWGEVEYVKAVDGVSFDIAEGESFGLAGESGCGKTTCGKSLLHLLEPTSGSVRFDGRDVTDPDVRDEMDFRTEAQIIQQNPYESINPRYRVFDWIKEPLDVHEIGTAEEREETVIETIESVGLNPPEAYMHEYPSELSGGERQRVSIARAIILEPSFILADEPASMLDVSVRASILDLLDRLQEELGISILYISHDLSLLKHMCDRIGIMYLGKLVEVGSATEVINDPQHPYTKALVGSTPTVDPDDRRESVELQGEIPDPVNLPSGCRFAPRCPEAMDECTAEEPAMYPTEAGQQARCVLYDEETVNTIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4I1</accession>
    <name>A0A3N6M4I1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_15660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87067">
        <property type="protein sequence ID" value="RQG87067"/>
        <property type="gene ID" value="EA462_15660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="342"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="506" mass="54455" checksum="532654E225E1E5E1" modified="2019-02-13" version="1">MTNQDEGISTLAKQGSITFVGNVVNGVFGFAIVMLMTRFVSPSVYGLFVLATSVILFMQVFANLGLPLAIDYFVPQYLDEGERGKAKGVIVQVTATVLVTSSLVALALAMSSDFVGEFFQEPAMRIALLLLSVTIPMLAIYNVLLTSYYSIKKLQYRVIMRDLVRPIVRFAVTAVLLLVGYGLLGLIAGYVIGLFVAITIGAAVFTYKAWDLLSTELEFVAPGPLVTYSVPLAMTSVVFVLMGHVDYFVLGYFLESDDVGIYRVGYMLGSGLMIIFNSLSPVFKPLIAETRDDVELVQQRFRIMARWIVAITLPVAIVLSLGASSYLAVLYTPQYAEASAVVALLAGAFLFNVTFGGPDGSLLQGLGYSRIVFANTLALFGTNFIVSMALVPIVGIEGAAIGSAAALFLVGALTLAEIYYLDRIHPFTRDFAKIVASGVPATIAGVPVVYVLESDLAIVAVLPVVVIATYLGTLILMDAFTDADAQMAAEFSPALRKWLPVSLFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4R9</accession>
    <name>A0A3N6M4R9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90231">
        <property type="protein sequence ID" value="RQG90231"/>
        <property type="gene ID" value="EA462_09615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043859">
        <property type="entry name" value="DUF5821"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19138">
        <property type="entry name" value="DUF5821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="272" mass="29760" checksum="EDD21AE08B0DAF9A" modified="2019-02-13" version="1">MTSNLLNHQIDDILESVLEDARGDVYMVNPSREAIEEFVTVATSFDGAVPSVHMLADERTLKDVMDDFIVASNAADLIADGTLSLRTIEQAPENSLLVTEDRVIAVVHAGDRVGGLVTDEESFVEDTYDTYTNRWDDAASYNLRTPPITDVRETLADEISPDAEDDFTAILNSLETARGDGDGLDEVTISLLVAAKNEALLYDISKWGEDVGIASKATFSRTKTKLEDMGLIDTEKVPIDVGRPRLRLKIGDDRLREADNGQLATVAQSILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5E7</accession>
    <name>A0A3N6M5E7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91240">
        <property type="protein sequence ID" value="RQG91240"/>
        <property type="gene ID" value="EA462_04415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="192" mass="19525" checksum="6F24439D2635C022" modified="2019-02-13" version="1">MGGLVQGNGCTIDEDVTTGYGEFDEPTRIGHDGTIRAGSIVYGDVTIGDRVSTGHDVLIREGTRIGDDVLVGTKTVIDGRTTIGSRVSLQTNVYVPTETTIGSDVFVGPSAVLTNDEYPVRSDGQLQGPTIEDGASIGANATLLPGVTIGENAFVAAGAVVTDDVPADTLAVGSPATTRPLPAALEGANQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5K5</accession>
    <name>A0A3N6M5K5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91310">
        <property type="protein sequence ID" value="RQG91310"/>
        <property type="gene ID" value="EA462_04815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="466" mass="52373" checksum="0C252C7CBB34B925" modified="2019-02-13" version="1">MLGDTPAVDEGRPPGPDGLPIIGTQLAFLRDPYDFMTGVARKYGDIAHWRDSGGDVYQLNHPAYIEQVLVGNNESYVKGATFQNILGPITGNGILNSEGEVWRRNRHRIQPAFHPDRIREYAEMITEFTEDVLEDWRDGETRNVHEDMMELTLKIVARALFGAEVDAHVDTVGSALEEFMLATENLAHLVLPPSVPTPGRLRIRRARKNLDEVVYRLIEERRRNPTEHDVISTLLDAGHGGDGRSETAGRGPTGTERGVDGTMSTEQLRDEVVTLLLAGHETTALALTLTFYLLSKNPAAEETLVTELEDVLDGETPTVDDLSELSYTERVVEESMRLYPPVPGVVREPVKPDVIGGYEIPPGSTIRMHQWVVHRDPRWYDDPLAFRPERWSDEMKADLPKLAYFPFAAGPRRCIGDRFAMLEARLILAAVYREYHLEAVPGTDLDLMATITARPKHEIPMTIRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5M0</accession>
    <name>A0A3N6M5M0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91330">
        <property type="protein sequence ID" value="RQG91330"/>
        <property type="gene ID" value="EA462_04945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036825">
        <property type="entry name" value="MTH865-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024093">
        <property type="entry name" value="Uncharacterised_MTH865"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07747">
        <property type="entry name" value="MTH865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69025">
        <property type="entry name" value="SSF69025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="83" mass="9142" checksum="B018545CF5A31EC0" modified="2019-02-13" version="1">MVDETDIREQMIEAFEGAEYPISSPMDLVPALPNGPGTSFESGEFSMTAMELNTKTSGGDFPYDDVETFVDDIIEDLKEQGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M644</accession>
    <name>A0A3N6M644_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_05990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91510">
        <property type="protein sequence ID" value="RQG91510"/>
        <property type="gene ID" value="EA462_05990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041154">
        <property type="entry name" value="AglB_P1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18079">
        <property type="entry name" value="AglB_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="AglB_L1" evidence="3">
        <location>
            <begin position="740"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="815" mass="88681" checksum="9614F6451BF3D11B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M694</accession>
    <name>A0A3N6M694_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glutamate synthase large subunit</fullName>
            <ecNumber evidence="17">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">EA462_10400</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="17"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88806">
        <property type="protein sequence ID" value="RQG88806"/>
        <property type="gene ID" value="EA462_10400"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="16">
        <location>
            <begin position="26"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="884"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1484"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="884"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1497"/>
            <end position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RQG88806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1514" mass="165238" checksum="3ECEAC8896062394" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M735</accession>
    <name>A0A3N6M735_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cobA</name>
        <name evidence="6" type="ORF">EA462_12365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89156">
        <property type="protein sequence ID" value="RQG89156"/>
        <property type="gene ID" value="EA462_12365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="302" mass="31193" checksum="EB63A7D709B84230" modified="2019-02-13" version="1">MSDTDAESDDSDEPGTVYLVGSGPGDPDLLTVKATRLLENADVVLHDKLPGPEIIEMLPEDRREDVGKRAGGERTSQSEINERLVDLAREGNAVVRLKGGDSFVFGRGGEEAEYLAAHGVPFEVVPAVTSAIAAPAVAGIPVTHRDHASSVSFVTGHEDPTKAESAVDWSALAATGGTIVVLMGVGRLPDYTAALLEAGMGPETPVALIERGTWPGQQVATGTLETIVDVRDEAGISPPAVTVIGGVAATRESVLEFLRNEDGTAVATDGTPTGDGEPPDKGGEESGKGGEARSENGERGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M764</accession>
    <name>A0A3N6M764_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_12530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89186">
        <property type="protein sequence ID" value="RQG89186"/>
        <property type="gene ID" value="EA462_12530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="44"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="111"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="322" mass="34684" checksum="EE171170EE4E3611" modified="2019-02-13" version="1">MTDPDVVVLREGTEGLSMESYAETLRERLPDATVELARTPQDERELASSARVVTGITIDEDLIERAGRLELFACTFAGTDHVPMDALADHGVMVTNAGGIHAPGIAEQAIGNMLVFARRLHEGWRRKQNDEWRHFPSFEFTDSTVTIVGLGSIGRATAQRLAGFEVETIGIRYTPSKGGPTDEVLGFDDEDIHEAFSRSDYVVLACPLTDLTRGLVGEAELATLPPNAVVVNAARGGIIDTDALVSALQFEGIRGAALDVSDPEPLPADHPLWDLENCLITPHTGGYTPNHWDRLADIVAHNVDVLGSGGDLENVVLTPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8H8</accession>
    <name>A0A3N6M8H8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TrmB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_07030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89766">
        <property type="protein sequence ID" value="RQG89766"/>
        <property type="gene ID" value="EA462_07030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="111"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="354" mass="39004" checksum="1E3DB27AE36E6DD9" modified="2019-02-13" version="1">MASDELRSTVERVGDRFNLGEYEIDAYLTVLEQGQLTASEISDRTDIPQPRVYDTVRSLSDRGLVELRESRPMKVVALDPGDAFDDVQESLTKMIDELEARYTAPARDTEAVSLVKSRSTILRYFEEVIGSAEYELSLSLTPDLLMRFETELSAVVDAGVSVDLLVTPASEAPDPDEFDYTAVATSARARRGITTPVIAVADGNYSIYATQDALRDDQDRYGVIFNRSALGFLVSGFFGTVLWTTAEETLSEDGAARTYPRKYASIRRCVKDILEEGGEFYATVEGRDVERGGSRVVRGRVLDVSFEVSEEVAGLTLEDDSGEEITVGGRVAALEDIESHEIHIGRNEPPAIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9T2</accession>
    <name>A0A3N6M9T2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90316">
        <property type="protein sequence ID" value="RQG90316"/>
        <property type="gene ID" value="EA462_10090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="89" mass="10112" checksum="F47820F17C8F9FB5" modified="2019-02-13" version="1">MLGRLQLSPSGILRSFVEWFVDRLGRSLGIVPQLARVGYAYEVEAFSNEEVVLERRTFEDGMEPSCSLEFVDEVSTSVSGVRKEVRRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9U2</accession>
    <name>A0A3N6M9U2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_10145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90326">
        <property type="protein sequence ID" value="RQG90326"/>
        <property type="gene ID" value="EA462_10145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="234"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG90326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="42491" checksum="1A74AC508ECFB841" modified="2019-02-13" version="1">MELLDDSIVPEHAHDLKARAHEFAREWIEPHAQEHFRSGEYPHEILEAGQDAGLVAGDIPEKWGGNGFGLPELLAITEEFYRADAGIGLTLQLASFGCEITYEYGSDEQCEEYIRPVAAGEQLSGLAVSEPETGSDLAGMETTAEKDGDEYVLNGEKYWIGNGVEADWVTLYARTGDDENNRYGNHSMFIVPTDTDGYEAEHIPEKMAMRASKQAHITLEDCRVPEENLIGTEGAGFWMLAEFFNHGRVIVAGHGLGLAAAAIEEAWEFTHDREEFGRTINQFQAVQHGLADMLIDFEGARALTWRACEKVDRGESAGYWAAMAKTGATETAVSVSEQGMQFHGGRSILDERRIARVYRDARVPVIYEGANEVQRNLVYRQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBN5</accession>
    <name>A0A3N6MBN5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF420 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92881">
        <property type="protein sequence ID" value="RQG92881"/>
        <property type="gene ID" value="EA462_01265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007352">
        <property type="entry name" value="DUF420"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37692">
        <property type="entry name" value="PTHR37692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04238">
        <property type="entry name" value="DUF420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="188" mass="20384" checksum="25BDE634D2ADC4A7" modified="2019-02-13" version="1">MEYVSRERVRPLTLVLSVVSLAVVFAAAGGRVPASAVPGAPQWVLDLIPHVNVAISAAAIGTIIYGWRAIRRGAVDRHRVSMLVSFGLFGTFLTLYLYRLIATGGPQPFPGPDLLYQFVYVPVLAVHILLAVACIPVLYYALLLAAAYPIAELPRTSHARFGRIAASLWLISFSLGIVVYLLLHVSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBS9</accession>
    <name>A0A3N6MBS9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating)</fullName>
            <ecNumber evidence="4">1.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gap</name>
        <name evidence="12" type="ORF">EA462_01540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.59" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92931">
        <property type="protein sequence ID" value="RQG92931"/>
        <property type="gene ID" value="EA462_01540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043891">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="11">
        <location>
            <begin position="16"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="7">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="7">
        <location>
            <begin position="222"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG92931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="357" mass="38310" checksum="1E8A055F07B8BB18" modified="2019-02-13" version="1">MSEHSYSGDNGSSEPLRIGLNGFGRIGRNVLRASLSYDDVEVVAINDVMDNDDMEYLLRYDSVHGRLEDVSRDGDALSVQGREIQLLSERDPAALPWDDLEVDVAFEATGLFRTHDDAAQHLEAGADKVLISAPPKGEKEVQTIVYGVNHDEYDGADVVSNASCTTNSVAPVVKVLDDEFGIESGLLTTVHAYTGTQSLVDGPLAKRRRGRAAAENIIPTSTGAAIATTEVLPQLEGKLDGMAIRVPVPNGSITDLTVDLEADVTEDELAEAIREAADDELAGVLGYTDDEIVSRDIVGLPFSSYVDLESSMVLEDGLVKVLTWYDNEFGFSNRMLDLATYVAAEADSVDAEGAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC61</accession>
    <name>A0A3N6MC61_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91286">
        <property type="protein sequence ID" value="RQG91286"/>
        <property type="gene ID" value="EA462_04680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="161" mass="17187" checksum="E7753FC88DB1E9CD" modified="2019-02-13" version="1">MTQNPLTALFDAQRTAIEQSQNFTHDAIEAQRTSISALSDGLETAGSLAESNAELTSGAVHASLDALESALPEEAAQFDDLREFVDESVDATTDAQTQSLEATIDALEESEAAFDEFTVNYSEVVDSSFDAFLDAHEQAEANVTAVAENVEEATDEFDVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC75</accession>
    <name>A0A3N6MC75_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4326 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93091">
        <property type="protein sequence ID" value="RQG93091"/>
        <property type="gene ID" value="EA462_02490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025475">
        <property type="entry name" value="DUF4326"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14216">
        <property type="entry name" value="DUF4326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="108" mass="12236" checksum="F2FB57789EC0AD18" modified="2019-02-13" version="1">MTTERVHKSEPHDVYIGRGQNGETNMGGVPIGVTGWLGNPYKESHYGREKCIELFERDLGWMVEGNPVFRAKLVSLYGKTLGCYCFDHQECHGDVIVSKINELYLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCA3</accession>
    <name>A0A3N6MCA3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91336">
        <property type="protein sequence ID" value="RQG91336"/>
        <property type="gene ID" value="EA462_05000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="182" mass="21357" checksum="9277A18A8685B4FA" modified="2019-02-13" version="1">MSDEESPVPEGVLTSAKDQLNEDEISLADNEEILHALSELTLVYENDRSYFVLGNYDREPIRRLNLVVDRLNRRQDTYAFRMVDIRGEWDNSIQKFCLIADIVTYLVGVAEKEPSDFLVEQGLLVGTTEYFSKSHVLKREYEDETYPFGWMQDGVFELFEKKGRLYRWRTEEQLVDVTENLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCQ3</accession>
    <name>A0A3N6MCQ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91526">
        <property type="protein sequence ID" value="RQG91526"/>
        <property type="gene ID" value="EA462_06075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="399" mass="45440" checksum="038B31974474E608" modified="2019-02-13" version="1">MNILMTIWGDYPPDARVRKQAKTLLNAGHNVRILCESDSPGIENIKGATVHRVYRPDPGHNLRDVPRSIELLLKNVDPLWRDEVQNEIKKNVDIIHVHDLPQARTVLQESNVPVILDLHENYRKAIYHYRPDLNFWKILTNPKILARRVCKPPWRYHWEQKFAMKNADHVLAVVPEARDEYIRSGIDPEAVSVVSNTVDLEWFDRHIPNSDDLYSEEFTLTYVGSVSGPHRGLDTVIRAIPRIKKEIPNVLFRIAGGGQLNDLEDLANNLGIRDHIEFTGWIDETEFPKYMSSANIGLLPHRSNGHTNTTIAHKLFQYMAAELPVIVTDTRAVGRVVREASAGVVVPPEEPNAIADAAINIFQSEVGRIYGKNGRNAVESKYNWSHDSKQLLKVYDKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGY0</accession>
    <name>A0A3N6MGY0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="7">IPP isomerase</shortName>
            <ecNumber evidence="7">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="7">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fni</name>
        <name evidence="9" type="ORF">EA462_03375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93246">
        <property type="protein sequence ID" value="RQG93246"/>
        <property type="gene ID" value="EA462_03375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="PTHR43665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_dh" evidence="8">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_dh" evidence="8">
        <location>
            <begin position="168"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="7"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="272"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="293"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG93246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="353" mass="37273" checksum="F36A802D7C84B1B0" modified="2019-02-13" version="1">MPETSDRKDDHIRIIEEEDVETTGAGFADVDLVHEALPEIHRDEIETSTTLFGHELSAPIVIESMTGGHPNTTKINRALAEAAQRTNVAMGVGSQRAGLEIDDEALLESYTVVRDVAPDAFLYGNVGAAQLLEYDLGDVEAAVEMIDADAMAIHLNFLQEAVQPEGDVDARGCLEAIEHVADGLSVPVIVKETGNGISRETATRLADAGVDAVDVAGQGGTTWSGIEAYRAAAVGARRQEAIGQLFRAWGVPTVVSTREAVDAHDCVIASGGVRSGLDIAKAIALGARAGGLAKPFLGPAGQGTDAVVDLIETLSLELRTAMFVTGSASVDELRSAEYVVLGRTNEYLEDRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRM8</accession>
    <name>A0A3N6MRM8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86923">
        <property type="protein sequence ID" value="RQG86923"/>
        <property type="gene ID" value="EA462_14785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="118" mass="12567" checksum="C9A6F669513EC4A3" modified="2019-02-13" version="1">MGSRTDAILSLFVLAVAAVAFVVVDASLSTSLFVFGGFATVAFEIVAARDRERIRRWWDTPTVQFVAVVLAIGAVIAGTTLAPTSSLSAVVGALVTYLAYLAVVRLSDSRKTTDDERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWI1</accession>
    <name>A0A3N6MWI1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89842">
        <property type="protein sequence ID" value="RQG89842"/>
        <property type="gene ID" value="EA462_07440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="506" mass="52808" checksum="2B407EAB4C5B8826" modified="2019-02-13" version="1">MDRRIPNPIRLCLLWIGLALARVGLIDPDRARRVTSLAWPRIVTGLARMSKSAVDVAMVGIAVGSAAIAGVGFAAPFWGLAFSIGGGVAGGTIALVSQRYGAETFDQLGQAVRSSTVLVVVVSLPITAAFWQYSAELISLISDDPEAIELGAAYLQIVGLGVPFAGLNLVGSRTFVGMDDAWKPMIIRAGGAVANIALNALLIFGLEMGVVGAALGTVLANVVVTAMFVLGLTAGWLPGVGSFPTAVDPYGSYLHGRTIWDLTKIGLPVFGTTLVWTVAEFPMLAIVDLFGQDTVAAYVIVRRIWGLMNTPSWGFGLAASSLVGQELGVGNEGRAAQYGREIVRFSVAVYVLAAGIVFVFAGPIALAFVDDPSELSIPTTVSLIYAACIAVVLQGVYTGAEGALRASGDTRWPFYSQLLGMFGLAIPLAYLGAAGLTIPALGPIPGTTVTVPGVTVPPLGLAGLALAFLAETTVPAVINYYRFSTGRWKAISRDYRPQTETSPTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWN9</accession>
    <name>A0A3N6MWN9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_07780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89902">
        <property type="protein sequence ID" value="RQG89902"/>
        <property type="gene ID" value="EA462_07780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="311"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="533" mass="58468" checksum="D3C87E0EB01945AE" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXG5</accession>
    <name>A0A3N6MXG5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90202">
        <property type="protein sequence ID" value="RQG90202"/>
        <property type="gene ID" value="EA462_09445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="256" mass="29118" checksum="F1CBDA2268DB2CC2" modified="2019-02-13" version="1">MVDRVILYRAPSSVVDVDELATWLERRTDVDVAVRDRFLEVHRSDELPERFAEARVTSPYERATGNTMLGTIRYEERALENPDREGGVLYDGVSVQRTLNSVLPASERELETLHVPIIDRAIGTWGGHDGRWHKRVNVLGQPALVSVPGLYEAPAKPEAYYKEKQRHSLISGDTPPREVLENQVDGEFLIENDPRSTDALAGYVLQAYHFIEEGSGFCEREGCRLFNAHYHEDLIEAQLRRPAFCSEHARLYGTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N075</accession>
    <name>A0A3N6N075_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91272">
        <property type="protein sequence ID" value="RQG91272"/>
        <property type="gene ID" value="EA462_04590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="235" mass="26152" checksum="2D5554C904F88570" modified="2019-02-13" version="1">MSIETADMDVERAGLRSLADGGIVAQLRLDHPDLVLRPTLERVPDVTVQPEYWTTIDTDRTLLFLTAYGSSFGAFETALETDSTVRDPVLVDRYPDRHVYRVTLADGTRTVIARTAEVGGRVLELSSTRDGWLVQLRFPTRDALVRFNEFCRAHGISVTVDHLRRSDDDNEGVVALTDKQEKLLTVAHEEGYFEVPRGISQDELADRLGVSKSAISQRLRRAIGELCDASLSSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3K1</accession>
    <name>A0A3N6N3K1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92702">
        <property type="protein sequence ID" value="RQG92702"/>
        <property type="gene ID" value="EA462_00250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="135" mass="13970" checksum="7780D43FD9249A4D" modified="2019-02-13" version="1">MTRHLLVPMDDSDPARAALRHALTTFPGAEVTVVHAVDDLEAGYGGDPGMGDVSSSSDPEFFDDVRAAAAEHDASVEPTVLRGTAATAILEYADEADVDQIVIGSDGRAGVSRVLLGSVAEAVTRRSSVPVTIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3S4</accession>
    <name>A0A3N6N3S4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92792">
        <property type="protein sequence ID" value="RQG92792"/>
        <property type="gene ID" value="EA462_00755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="203" mass="22525" checksum="6D4946B28AFB8FF7" modified="2019-02-13" version="1">MDVYHVTDGAEIFTCNAFLAIGDQTTLVDASSWDGVVDEIRERTDDVDAVVMTHQHGDHVSQLEAVVDAFDPDVYAYDDHPTRTHSIDDGDTVPIGDETFDVVYTPGHADDHVSFVSERSLFSGDVVVHDDGAFEYGSFGRTDMAGQSREELIESIERLRERLPEGVEHLYAGHGGVFHGDVRDVVETALERATNREPKYPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4K3</accession>
    <name>A0A3N6N4K3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93112">
        <property type="protein sequence ID" value="RQG93112"/>
        <property type="gene ID" value="EA462_02595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="149" mass="16848" checksum="54B9103FF5AD5297" modified="2019-02-13" version="1">MPSRRGLELDRGERLYYRGGLRKGGEIAVTDARVLVRDDDELTSVPYTNVSEVATESFNWFLSLLSGALVLFGLYSIPENALLGGTFAAFGLWSIYRSYRHRDRVRIHTHSQPKPVEVFPENVDTLYDELEPAIEAARAERGRETAESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4P1</accession>
    <name>A0A3N6N4P1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93152">
        <property type="protein sequence ID" value="RQG93152"/>
        <property type="gene ID" value="EA462_02820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="372" mass="38998" checksum="C5CCBFEDDEC98B50" modified="2019-02-13" version="1">MDRLAGRLVRRFRDDADEPTVAGLEDEDADKLFDALGSKTSRAILAACYEQGRTRSELADDLETSIQNVSYHVDKLESADLLEAVETRYGQNGREVTVYEPSKRAVVVAAGEPGVVDRLADAVDRLFAPITFVGLLAMTVAAIVRGPARVGMLGDDAGTATTAPTAPEPWLVAAVLAALCGTLIVFVADRLGAFERDGAVGAARTGVPRRLFGRHVGSSRRYAVWIVAFAFATFLALDLVAVGAGHRLTVLAWLAVQLAIPAGLVGAAAVAYLNDGLVASWAAASAPFAGLWGYLVAGDIVRGGFEPILLALGPVAVLVVATPLGTLSYLAGRLLATRRERGVDLSRRAAGALVAHPIAVVALIVSWVVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NV10</accession>
    <name>A0A3N6NV10_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Digeranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">DGGGP synthase</shortName>
            <shortName evidence="9">DGGGPS</shortName>
            <ecNumber evidence="9">2.5.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Geranylgeranylglycerol-phosphate geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_15780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18109"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="EC" id="2.5.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.42" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87090">
        <property type="protein sequence ID" value="RQG87090"/>
        <property type="gene ID" value="EA462_15780"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047295">
        <property type="term" value="F:geranylgeranylglycerol-phosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01286">
        <property type="entry name" value="DGGGP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023547">
        <property type="entry name" value="DGGGP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG87090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="283" mass="29157" checksum="BC0B5781A6E44629" modified="2019-02-13" version="1">MTAAETIRGLLELMRPVNVIAASMLTFIGAFVAGGVTDVPLEVGAAVAATGLAVGAGNAINDYFDREIDRINQPNRAIPRGAVSPGSALGFSIVLFVAAVAVALTLPWLAVAIAAVNLVALIAYTEFFKGLPGLGNALVAYLVGSTFLFGGAAVGEIGPSIVLFVLAALATLTREIIKDVEDIEGDREQGLNTLPIAIGERRALQVATALLVVAVLASPIPYLHEDFGIAYLLVVIPADAVMLSAVITSFDDPTAAQSRLKYGMFLAALAFIIGRAAVGVSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NW90</accession>
    <name>A0A3N6NW90_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclophil_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88779">
        <property type="protein sequence ID" value="RQG88779"/>
        <property type="gene ID" value="EA462_10250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025658">
        <property type="entry name" value="Cyclophilin_TM1367"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04126">
        <property type="entry name" value="Cyclophil_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophil_like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="126" mass="13473" checksum="1B81035FCB2E5803" modified="2019-02-13" version="1">MTDLRLTVGGIELEATWTNDAPETRAELDAALPVSGDAIRWGDELYFDAPLGVSSENAREVVAEGSIAYWPAGGKLCLFWGETPASVDGEPRAAAPVNVVARATETKPLETLEGGARMTLERAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWD9</accession>
    <name>A0A3N6NWD9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88849">
        <property type="protein sequence ID" value="RQG88849"/>
        <property type="gene ID" value="EA462_10640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046164">
        <property type="entry name" value="DUF6166"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19663">
        <property type="entry name" value="DUF6166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="133" mass="14315" checksum="F8374755895A682B" modified="2019-02-13" version="1">MSHDVGGETQGSSIQSTDPGPSATTDSAETVYHGYRDPTSPVGEECTVSVDGEPLDFRYDLLSASRSGFEWGYGGSGPAQLAIALLAHAFDGDIACDHYQRFKQDVVANLPEKGWTLHSSDLDAWYKEVNADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX34</accession>
    <name>A0A3N6NX34_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Copper resistance protein CopC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_12600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89199">
        <property type="protein sequence ID" value="RQG89199"/>
        <property type="gene ID" value="EA462_12600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CopC" evidence="9">
        <location>
            <begin position="49"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="10">
        <location>
            <begin position="363"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG89199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="681" mass="71054" checksum="664037E0821D5395" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYK2</accession>
    <name>A0A3N6NYK2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89919">
        <property type="protein sequence ID" value="RQG89919"/>
        <property type="gene ID" value="EA462_07870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="156" mass="16549" checksum="C98CA522EEB09B53" modified="2019-02-13" version="1">MFDRVRAILAPDSSETTARDRGVGLFVDGPNVLREEFDVDLDDLRDAARDLGRVGVIRLYLDEHATPGLIQAAEARGFEVIVTSGDVDVKLAVDATALTGDGTIDSLAIASRDTDFKPVLEYAGTVGVETIAIAPGTYGRSDALQNAADRAVTIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ12</accession>
    <name>A0A3N6NZ12_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_16450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86726">
        <property type="protein sequence ID" value="RQG86726"/>
        <property type="gene ID" value="EA462_16450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="264"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="512" mass="55495" checksum="4C7DD82576F421AE" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZF7</accession>
    <name>A0A3N6NZF7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86926">
        <property type="protein sequence ID" value="RQG86926"/>
        <property type="gene ID" value="EA462_14800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="1">
        <location>
            <begin position="18"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="343" mass="37139" checksum="71ECC9FB4A488DE5" modified="2019-02-13" version="1">MQFGYSEVCLAHDPGSRHPETPDRLRAIRERLKRKHGVEYVEADPCDVEAITAVHDREYIESLEEFCADGGGEWDPDTTAVEATWDAVRRSAGLACWAVESALEGADGRKTPFSLGRPPGHHAVGDDAMGFCFVNNAAVAAQYALDHDNYDVDRVAIVDWDVHHGNGGQDIFYDRDDVFFVSVHEQGLYPGTGDVDETGEGDGDGMTMNLPMPAGTDDLEYLAAIGGPVTAALEGYDPDVVIVSAGFDAHRHDPISRIRLSTEAYALMTDRLRALANDTDAELAFVLEGGYGLDVLADSVALVHETFDGREPIEPGGELSDQAESALEDVLEAHGLDLDLDCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZI7</accession>
    <name>A0A3N6NZI7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metal ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_15025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86966">
        <property type="protein sequence ID" value="RQG86966"/>
        <property type="gene ID" value="EA462_15025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="250" mass="26751" checksum="A187F4635B19E02B" modified="2019-02-13" version="1">MNHAITVENVSFSYGDRPVLKDVSLSVETGEFLGLIGPNGSGKTTLVKIMLGLQTPDTGTVELFGTPASTFTEGTRLGYVSQQSSEADSMMPVTVREVVEMGRYPHAGLGRLSDDDDAIIGDALEQVDLTDLANRRISKLSGGQKQRAYIARALASEADLLALDEPTVGVDAESVETFYELLEELNASGITIVLIEHDIGIVTDHADTMACLDCELYEHSETEQFLESDALERAYSSARVASAANVSAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0Q3</accession>
    <name>A0A3N6P0Q3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Imidazolonepropionase</fullName>
            <ecNumber evidence="1 4">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hutI</name>
        <name evidence="6" type="ORF">EA462_14515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1 4"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88108">
        <property type="protein sequence ID" value="RQG88108"/>
        <property type="gene ID" value="EA462_14515"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01296">
        <property type="entry name" value="Imidazolone-5PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00372">
        <property type="entry name" value="HutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="73"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="412" mass="43226" checksum="4CB3A6CE1D4C79CC" modified="2019-02-13" version="1">MTDLQFVVHGAAEVAAVSDADDAGPAAGLETIADGAVAVVDGEIAAVGETATVTRDYPPENAATAIDAAGKTVQPGFVDPHTHAVFAGDRSDEFEAKLRGKSYQEIMAEGGGILRTVRATREADTETLLANLLDHLDLMLAHGSTTVEVKSGYGLDTETELRMLEVIDRANERHPIDLVATYMGAHAVPEDRDTDEYVDEVVDEQLPAVADQGVAEFCDVFCEEDVFDVAQSRRILEAGRERGLSPKAHAEEFVHLGGTQLAADVGATSADHLLNATSDDVRALIDAGTVPVLLPGTAFGLRTEYADARGMLEAGAPVALATDFNPNCHSHSMGFATTLACVGMRMTPAEALIGATRNAAAAIDRPNGPGRLEVGGPADLCVLDAPSHVHVPYSFGVNRVETVVKDGEVVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P156</accession>
    <name>A0A3N6P156_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88785">
        <property type="protein sequence ID" value="RQG88785"/>
        <property type="gene ID" value="EA462_10280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
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        <property type="entry name" value="ADH_N"/>
    </dbReference>
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        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="352" mass="37978" checksum="9D33E60E4BBED5E7" modified="2019-02-13" version="1">MQAVKITEHGGTDVIEYGEYPDPDVGPDEVLVDVKAGALNHLDVWVRRGLPTLSLEMPHVPGSDAAGVVAEVGRDVTRFEPGDRVAVTPGVSCGDCEFCRHGDPTLCVNFHLIGEHVPGLHAEYTAVNEENLIPVPDDVDWLTAASTVLVFQTAWRMLIDRAGVEAGEKILVLGASGGVGHAAVQIADFAGAEVYATGSTDDKLEYARAHGADHVVNYEHRDFSEWVREKTGKRGVDVVVDYIGAGTWQDSIKSLAKNGRLVTCGGTAGGNPRTDIPRIFWNQLQIIGSTMGTPGQVDDVMELVWDGTFEPSIRAVLPMSEMARAHEIIEDREGFGKVVVRPDSEYTGRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P213</accession>
    <name>A0A3N6P213_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89165">
        <property type="protein sequence ID" value="RQG89165"/>
        <property type="gene ID" value="EA462_12420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="99" mass="11314" checksum="2CE7F31BFDC58C25" modified="2019-02-13" version="1">MAMKENRPRLGSGTTVYTETGRPIGRIRGFDEDGFYVTLRDGLEGLSIEHVRSGHEFGEAHLMWRCLECGEMGTLENDFPSSCPSCNTERENLYYWTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P228</accession>
    <name>A0A3N6P228_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_06625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91619">
        <property type="protein sequence ID" value="RQG91619"/>
        <property type="gene ID" value="EA462_06625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="157"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="290"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="365"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="417"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="492"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="685"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="895" mass="100729" checksum="5DF1CD883BB0418A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3D1</accession>
    <name>A0A3N6P3D1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inositol phosphorylceramide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_07080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89775">
        <property type="protein sequence ID" value="RQG89775"/>
        <property type="gene ID" value="EA462_07080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="6">
        <location>
            <begin position="156"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="294" mass="32923" checksum="78DA7AE4859CE07B" modified="2019-02-13" version="1">MSLVGLVLELVIVVVTMLVTATLVIVGPRRFMASLSGFRRRIEVCTLPLAALAVVLALRWSTVDPFMRLERRVLGTNITPLLFELEFGEQALLPVNPIVLLQSIQSPEVTSFFIFVYVYGYAFLLLFPFIAYFALEDSEDLRTLLLAFTANYGIGLICYALFIAYGPRNVDPTIIEGVLYDAFPQSGLLTHRVNQNTNVFPSLHTSLSMTVFFVAWLTRAKYPLWLPISGVLAISVALSTMYLGIHWFSDVVAGTILAAVSVYIGRTYTVDGILESTRQYLDRRYDRLRRTGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P487</accession>
    <name>A0A3N6P487_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92719">
        <property type="protein sequence ID" value="RQG92719"/>
        <property type="gene ID" value="EA462_00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="348" mass="37975" checksum="15679EC151B74C82" modified="2019-02-13" version="1">MSDENRLSRRQLLVRGGGGVSLIAGGVGTYNEILGYDRLTGTNVVRQDLDPIVSEHLGAATDTLTTVSGRHIDHENGALTVQEVAVSNGSEAGNGPSTLTSFEWSETSPAEAAKLDEELGLDTEGSPLEQLTTDLSALEATEIDFVYGTLAEFFEYAREGESRPYTVDALRGRVGGVDPGVLEEFTGTPASDVEALIDGLADGFQEFTTYDASRYLAGSLEDNVLFGRGDLRARFESPADFTAIVGGENDGLDCTEMSRRTIEAVHTAHPLEQTVPVVAGYVRDLRHSHFYVTLATVTRVDGELVIPVTFVDYMYTTLVDDFRLDRLARVDPSAYDRYHRADEIRWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4L6</accession>
    <name>A0A3N6P4L6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92909">
        <property type="protein sequence ID" value="RQG92909"/>
        <property type="gene ID" value="EA462_01420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="86"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="320" mass="34644" checksum="C79233C8ED832A36" modified="2019-02-13" version="1">MTQLRADEPHPDARAVLEAYHSTSVPPFDEISPAEARTMMDTMYSSEEPSIELESVSERSIDGARGEVPVRIYDSGQNTAGSRPIILYFHGGGWVVGSLDTHDETCRKLAAESGYPVVSVGYRLAPEHPFPEGLTDCYRALEWLAGAAPELGADPDRIVLAGDSAGGNLAAATALLARDRDGPSVAYQLLLYPVTGDASETDAYEENADGYLLTADEMEWFLSHYLARDVDEGNVYALPRRAADLTGLPPATVLTAGFDPLRDDGVAYADRLQDAGVPVTLRNYDDLIHGFVGMLSEPMEIERAHDAVDDVVDDLRTALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4M6</accession>
    <name>A0A3N6P4M6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92919">
        <property type="protein sequence ID" value="RQG92919"/>
        <property type="gene ID" value="EA462_01475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="155" mass="17453" checksum="5D25D7CB1AB6438D" modified="2019-02-13" version="1">MANNDDVSHRLRGAIDGDVLFTIRDEFLRQAPLATATVDDMVSPSVLMVELTAGLQDESTGRFETQWTIEGDYKFHYTEDDLDFRWGHHPHGGDYNVQGDAHFHPPPNASSHPNDIEPSCFTVHRPKLVTRGVLKNWHAAYHDGPDELNSPEYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4Z0</accession>
    <name>A0A3N6P4Z0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93089">
        <property type="protein sequence ID" value="RQG93089"/>
        <property type="gene ID" value="EA462_02475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="144" mass="15415" checksum="A511F75B456F81FD" modified="2019-02-13" version="1">MMELISDAADQIDPVNADLEVIGIPGGIGKELEDYAIEGAHVRGARYMNTMSGTDIGINSKPKRVYLQPTICLGEGEDAEMVDVISFEELSALPAEYRSDLKIDAAAMTNKLIEKPLDEILQAVGVDTKAAIKGQSQTGLAAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P509</accession>
    <name>A0A3N6P509_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93119">
        <property type="protein sequence ID" value="RQG93119"/>
        <property type="gene ID" value="EA462_02630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="568" mass="59601" checksum="E4930F4A0D24B7F6" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P5B2</accession>
    <name>A0A3N6P5B2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93269">
        <property type="protein sequence ID" value="RQG93269"/>
        <property type="gene ID" value="EA462_03500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="97" mass="10398" checksum="83FBCCCA9C69B23E" modified="2019-02-13" version="1">MISLIGTTETAMALAVVKTLVLVVGSVITYFAFKAYRRTRQRALGYLAAGFGLVTLGLVLAGMLYEILEVPLAIGILLESLLVLAGFLVIAYSLYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9H7</accession>
    <name>A0A3N6P9H7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92895">
        <property type="protein sequence ID" value="RQG92895"/>
        <property type="gene ID" value="EA462_01350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="97" mass="11189" checksum="366AC553DB06A0B2" modified="2019-02-13" version="1">MKTVTTRIPEDDEEALAELEAELSADLPEVLRRLIRQGLSDWRTERALDQLRDHRITLRKAAELADVSYVEMLTLATEEGIDVGYTTDDLERDFDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHS7</accession>
    <name>A0A3N6LHS7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Archaeal flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the archaeal flagellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86754">
        <property type="protein sequence ID" value="RQG86754"/>
        <property type="gene ID" value="EA462_16600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097589">
        <property type="term" value="C:archaeal-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35903">
        <property type="entry name" value="PTHR35903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Arch_flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0974">Archaeal flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="188" mass="19899" checksum="6987E21A04150147" modified="2019-02-13" version="1">MFEDNENRGQVGIGTLIVFIAMVLVAAIAAGVLINTAGVLQTQAEATGEESTQQVSDRLDIVSSSGNVTETQTIDNVTFTMAMAPGSDPIALNQTTAQLIGSAGEETMSLQHDNISISNIQGIADEENPVLTSNSDRAEVTFQLNEVYEELDEGDRLTVSFTTAAGATTQTELRVPTTITSDDDSVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIE1</accession>
    <name>A0A3N6LIE1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86929">
        <property type="protein sequence ID" value="RQG86929"/>
        <property type="gene ID" value="EA462_14820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="3">
        <location>
            <begin position="281"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="428" mass="47422" checksum="7A47E296434F896C" modified="2019-02-13" version="1">MSTPVTLLCGELGAGKTTLLSRLLESTDLEIAVLVNDVGAVNVDADLVEARTDLSTGEEVVALENGCICCSLGNELSRSVIELQREHEFDHLVVEASGVSEPEPIARQFVRGPAAGSYDPNAIVTVVDARRFHDRFVDADSDGEPPAIEGADGGGTRPLADLVLEQVEFCDVLVVNKCDLVNERERDSVVALLETIQPRAEIVATEYATLEADSLLDAHRFDLEAATDAAGWKRALEDDANRERDHDHGGHDDHTHSHGEETSHDRGRDHHHAHPPERYGISVDSYHRRRPFHPERIVALLADLPPELVRAKGLCWIAGREDQAITMSQAGDETALEVTGRWIASLPERRRERYRRGQPDREWDDEWGDREIRLALIGRDLDLDALTDRFDDCLLTDEEMAADWSTFENRTPTAMGESTVVADERGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIU2</accession>
    <name>A0A3N6LIU2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoaD/ThiS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87896">
        <property type="protein sequence ID" value="RQG87896"/>
        <property type="gene ID" value="EA462_13620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="104" mass="11624" checksum="CDC73FF88A34E7F5" modified="2019-02-13" version="1">MTVEIRVFGPFRDVVGRKHVTWPVTRGMTVDDLLTELVERHPAVEHYLYDDDELVHRIAITKNKAHIGQLEGVDTVIEDGDTIRIAPPVSGGGSADYQPTEFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ01</accession>
    <name>A0A3N6LJ01_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88006">
        <property type="protein sequence ID" value="RQG88006"/>
        <property type="gene ID" value="EA462_14205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="329" mass="35827" checksum="07D7A6391DF7599C" modified="2019-02-13" version="1">MYPGAKAAQFVVKIGTETFREYSESVSEVTVDTAVDGADRCRIALTPPFDHEFGSFKNVALDSIGPGTGVSVGMAYGEESSAQLFSGEVETVEPTFPTAEPPWIVVTAYGHSRKMMRGTRSDSWKGKSLEAIVESIASNYFEDIEIEDGGITPQGVIQDNESDYRFLKRVAAKYGFEFFSSAGTLYFVPRDGGVSPGDPVTTLTYGSSLESFSATTKALRHGAVVVKYWDRERRKKISAEANNGSGGSPEVFRIRVSSQAEAQRIADSKLHTSRVTGVAKTFGIPSLVAGEVVELTGFSSEYEKNYYITDAIHRIGDDGYKTEFEVRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJI7</accession>
    <name>A0A3N6LJI7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88863">
        <property type="protein sequence ID" value="RQG88863"/>
        <property type="gene ID" value="EA462_10715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="209"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="416" mass="44641" checksum="035EC3FB442E63EF" modified="2019-02-13" version="1">MTISPDRDRLVETMEAQASIGATDGGGLHRLALSEEDERVRDWFSAQMDAAGLSTRIDEFGNMFGRREGTDPAAAPVLLGSHLDSQPSGGIYDGALGVVAALEFVRTLDDEGIETERPIEIVNWTNEEGSRFQPAMQGSGVWAGAHDKEEEYATTDEDGVSLKTALEGIGYLGDAPAEPLEEYDSYLELHVEQGPYLEDGGHQVGVVTGIVGFVWGAITFSGEPNHSGSTPMAHRSDALVGAADVITQVRRIPSTLGPRTVGTTGYVSASPNSINIIPGDVTFTFGFRDPDDEVVDEAFDRVLLEADAAADREGLDWRFEERMRVSSVEFADRCVDAVESAATSLEYDRTRIFSGAGHDASHASRVCDTGMVFAVSENGKSHTEAEYTSWDDCYAAANTLANAALELARPTDTADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJX5</accession>
    <name>A0A3N6LJX5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4870 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86648">
        <property type="protein sequence ID" value="RQG86648"/>
        <property type="gene ID" value="EA462_15995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="283" mass="30047" checksum="9530714AB4158F5B" modified="2019-02-13" version="1">MPSEHTPDTTSTTDGPRLLEERSIGGILVHFVAIPTGVVGAGLVYLVSTHEFTRRNARNALDWHLTVLALTILTFGSLFIYAEGTGQGATDVATLPSPVSATASVVLPVLISLWMFVTFWTFLVGLIAMGKATFGTAWRYPLSPALVDRFGPRVDLPGGWPVIIVVYVAVAPLIVGVALFGPREGAAFFASGLGLVALILVLTPITGVALYQHGARIRPTDADWQPPVVAYLGVPIAVAAAGYLLSEAVTDSINPAGDAVYVFLAAFWVASLVYAVRWWTESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK26</accession>
    <name>A0A3N6LK26_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89113">
        <property type="protein sequence ID" value="RQG89113"/>
        <property type="gene ID" value="EA462_12125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="290" mass="32666" checksum="86B4A16D22E60202" modified="2019-02-13" version="1">MNWHSKDLAAIVADPTNRAVLDVLVDADRRLTTMEIAERLVSRESGVVDSREYDRRLDERQLSLHHGVLPKLDEIGIIDYDARRNVVSVESDVGSEGVWAEFESIDELLARINAPDEADERTVGMLEGREALYEYGRTLADRSDDELFLIYTSDELLDGDCLPQAKNAIQRGVEFHAGVQGSGARQFFQERLPDATVWEPQLDWCSDPSVYPTISRLIVSDRKRVLVGLWDEPDADDRKASVDDGKTEIGMVGEGRRNPLVVLVRELLGPRLDHLDYQSDAFLGDLPFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKB1</accession>
    <name>A0A3N6LKB1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89203">
        <property type="protein sequence ID" value="RQG89203"/>
        <property type="gene ID" value="EA462_12620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="35"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="387" mass="42096" checksum="FEEE682058E9FF41" modified="2019-02-13" version="1">MNLHERIARRRSAHKGQGIVVDHDHLSPVVHRPEPVGRGPVLEQLLDALEPVFDGDLPSPVAVVGPPGSGTSAIVVALFDAMNDRLGESSQSIRTTTRAGSTEPTTWFVYVDARRVQSEFAFYRAVLSVLSSESVPESGIGTGALHDRLRDRLARHDRQAVVAIDHHHEPETLEYERVCELLEPVDSSVSTVAVGSAAPTDWAGTTVSVPPYRHHELVDVITDRTSTALAPGVIDHESLRDLAMWADGNAHDALAALFEAAAYARQDESDRIDHQHLERAKADVPEDGVHVDRALALSETRQQVLSHLVSLESDGQPIRDVAEEIATHSSLTAGTVKRFLYELADRGVIERVPLPANGTGRRPSAIEARFPPITFQSLSSTTDVDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKB9</accession>
    <name>A0A3N6LKB9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">V-type ATP synthase subunit F</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">V-ATPase subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpF</name>
        <name evidence="7" type="ORF">EA462_11815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89058">
        <property type="protein sequence ID" value="RQG89058"/>
        <property type="gene ID" value="EA462_11815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00312">
        <property type="entry name" value="ATP_synth_F_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022944">
        <property type="entry name" value="ATPase_V1-cplx_fsu_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="111" mass="11912" checksum="9020ADE6C2064622" modified="2019-02-13" version="1">MSQEIAVVGDPEFTTGFRLAGVRRFENVAAEEKGTELDDAVTNVLDDDGVGIVVMHDGDLEHLSRNVRQDVETSVEPVVVTIGSGTGGGGLRDQIKRAIGIDLMDEDEDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKG0</accession>
    <name>A0A3N6LKG0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89283">
        <property type="protein sequence ID" value="RQG89283"/>
        <property type="gene ID" value="EA462_11770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="425" mass="45453" checksum="1416D614F7282E9B" modified="2019-02-13" version="1">MRLSTAVTLALAALLVTSLLGVALAAPVAALGAEPESGTVSGADPPHESPSLSSLESGQVPEPSLTTTSNETPLPSAEPFQVIRINVSDDGDARWTIESRFVVSEEADEELLVEHADSVSSGDREVGYDVAQFEPFVDSAAGATDREMTLENAGWNAPHFEDPPEDADLDDDARIGVISYSFTWTNLATIDDGRIYFGDAFQSSAGTNIDLVDGQRLVIESPPNYGLETPTQLTWDGPHQFEDGDLEIVFLRGHVPDTGGSSPVVPAAGAVVALLVVGYLFYRFGRMSSGDGILPQSSRSEPSAAESELEETVTPAGENGGNEVASERPTAGGDDTPAGTSIEYQEELEEDVDLELLSDEERVHRLLKQNGGRLKQATIVKETGWSNAKVSQLLSQMDDDEEIDKLRIGRENLITLPEVDPTEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKN1</accession>
    <name>A0A3N6LKN1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87018">
        <property type="protein sequence ID" value="RQG87018"/>
        <property type="gene ID" value="EA462_15350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="72" mass="8347" checksum="C841E6E1A6C072E2" modified="2019-02-13" version="1">MVFSDEIGRGDRDRLADGELSIDECRETARDENRIEPQLRIERQLSGRESATTAAETPPRVVRPRPDRFYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLF5</accession>
    <name>A0A3N6LLF5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87940">
        <property type="protein sequence ID" value="RQG87940"/>
        <property type="gene ID" value="EA462_13845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="9931" checksum="5CFFA5BD4AB38903" modified="2019-02-13" version="1">MTDAQAPEPASDDAHKRITEETRIDISQPLDIDEMFLEAMADTDLLHFEYDDDDDVIARCEIDPRVLRSAMFLYSSMERTPHDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLG0</accession>
    <name>A0A3N6LLG0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_07275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89813">
        <property type="protein sequence ID" value="RQG89813"/>
        <property type="gene ID" value="EA462_07275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MacB_PCD" evidence="6">
        <location>
            <begin position="28"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="409" mass="42927" checksum="4FA2B54CF9700C36" modified="2019-02-13" version="1">MSVRGRSVRARAVAGIALVQLRRSPSRTVLAILAVAVAVLSVTLLTSLGAGVVAMGEDGLDTADRDIWISSDPVDPGASGTENSVVGSHAVAAELSEREDITGASPIAMHDVYIGTEPDDLERNPAVGVQRTHDGFGFEDGDGFETPEEAYEDARADDPVVEEIVLDPAIAGELDAETGDTVYVGTSRESAPEYEFTVVGTSAYYSQFLGSDTVTLPLVDLQAVAGTTGTDRSTFITANVTDDADRDEVRNELTAAYPDYDVRTSDEQVGAMLEERPLVIASGLTLVGLAVLGGSVLTVNLFTLVTYHQRTELAALRAIGLSRPVLAGTIGVQGLSIGLLGGIVGLAATPPLVRGLNHISTAVIGFERLLRTPLEVYVLGIGLALMLGTTVALVTGWRAGRYARIEHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLU7</accession>
    <name>A0A3N6LLU7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type II toxin-antitoxin system PemK/MazF family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90013">
        <property type="protein sequence ID" value="RQG90013"/>
        <property type="gene ID" value="EA462_08380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="117" mass="12737" checksum="56F9E72BE648F53B" modified="2019-02-13" version="1">MSEDTKVRRGDVVIVRLDPAEGHEMKKTRPAVVVQNDVGNKNASTTIVAPATGTYRGYPFEVLVEAAESPFEKDSSVRLDQIRAVSIEKRIHSVLGGLDTETMEAVDEALKLSLGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLZ3</accession>
    <name>A0A3N6LLZ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89958">
        <property type="protein sequence ID" value="RQG89958"/>
        <property type="gene ID" value="EA462_08090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="7169" checksum="374AEE0319953D02" modified="2019-02-13" version="1">MTSDRGTSGTTTLEFEMDATRFRSIDLANAAFAPSLVRFQRDKNDSGNLNTVKPNHRPNARVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLZ9</accession>
    <name>A0A3N6LLZ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Formate dehydrogenase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_08145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89968">
        <property type="protein sequence ID" value="RQG89968"/>
        <property type="gene ID" value="EA462_08145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015942">
        <property type="term" value="P:formate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02753">
        <property type="entry name" value="MopB_Formate-Dh-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041924">
        <property type="entry name" value="Formate_Dh-H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006478">
        <property type="entry name" value="Formate_DH_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01591">
        <property type="entry name" value="Fdh-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="711" mass="78940" checksum="88E2B498968C8361" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM54</accession>
    <name>A0A3N6LM54_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88837">
        <property type="protein sequence ID" value="RQG88837"/>
        <property type="gene ID" value="EA462_10575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="109" mass="12456" checksum="ED4A78FFC5CB0A8E" modified="2019-02-13" version="1">MGEEMPWWLNPKLGQLDNGTTLRHVYKSGEYEDDVVTAHVQGERIDVPGDTGPDDSDFTTRTPSGAAREADRRHRGADSRNDPYGYSGWDWWEYQDDDGEWVPISELPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM65</accession>
    <name>A0A3N6LM65_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="8">SHMT</shortName>
            <shortName evidence="8">Serine methylase</shortName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glyA</name>
        <name evidence="11" type="ORF">EA462_08695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90068">
        <property type="protein sequence ID" value="RQG90068"/>
        <property type="gene ID" value="EA462_08695"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="10">
        <location>
            <begin position="8"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="354"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8 9">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG90068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="416" mass="44641" checksum="382F467E92E2F109" modified="2019-02-13" version="1">MVDSDALTATDPEVFDAIRNERRRQENTLELIASENHVSEAVLEAQGSVLTNKYAEGYPGARYYGGCEHVDRVEQLAIDRAKTLFGAEHVNVQPHSGTQANMGVYFATLEPGDRILSLDLNHGGHLSHGHHVNFSGQLYDVTQYGVDPETGYIDYDELATLAEECDPALIVSGSSAYPREFEFDRIAAIADAVDAYHMADIAHVTGLIAAGVHDNPVGVADFVTGSTHKTIRAGRGGFIMTSDAYGEEIDRAIFPGGQGGPLMHNIAGKAVGFGEATEPAFERYAERVVANAKAMADVFVEHGLSVVSGGTDKHLLLVDLRDSHPNLTGEEAETALESVGITVNKNTVPGESRSPFVTSGIRIGTAAVTTRGFGRDEIETVATHIVELLDTPDDEELAATVAEEVDSLCTVYPIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM80</accession>
    <name>A0A3N6LM80_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90088">
        <property type="protein sequence ID" value="RQG90088"/>
        <property type="gene ID" value="EA462_08805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="219" mass="23874" checksum="26ED246FFAE13EC0" modified="2019-02-13" version="1">MRLIAHRGFAATAPENTIAAVKSAAEHADAVEFDVRRCGSGELVVIHDETLERVTGSEGTVADSSLEELRTRSVLGSGERIPTLEEMLAVVPTDTEINLEMKDHDIAADVLEALEGVDNRVVVTSFLSPELRTITDLDRSQPTGLLVNRRLETPVTTAVELGCDVIGANYWRCLGTRLVPRAKSVDLEIHAWSIERRLTAIVLGLRGVDCVSADRPIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNC5</accession>
    <name>A0A3N6LNC5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">EA462_15820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87095">
        <property type="protein sequence ID" value="RQG87095"/>
        <property type="gene ID" value="EA462_15820"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="43"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="14739" checksum="2AE8105882167CBF" modified="2019-02-13" version="1">MTTLGLVVAEFNRPITEQMEDEALETAHAAGASVSETVRVPGVYDAPLAADRLARLETVDAVVVLGSVITGDTDHDQVISDATAQRLSDVSLERDTPVTLGVTGPGMSAAEARERVENAAKAVDGALDLVSELPEPSEDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP02</accession>
    <name>A0A3N6LP02_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">H/ACA RNA-protein complex component Gar1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89787">
        <property type="protein sequence ID" value="RQG89787"/>
        <property type="gene ID" value="EA462_07145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="89" mass="9676" checksum="91D0C3D36D3B4FD5" modified="2019-02-13" version="1">MRRVGSVVRTAQGLAILRTDDTDESGVSERRGTDDEYRGEIGTVVIDDSLEKVGRVVDVFGPVDRPYLAVTPDDGVHLPSLVSSTLYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP04</accession>
    <name>A0A3N6LP04_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TVP38/TMEM64 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91148">
        <property type="protein sequence ID" value="RQG91148"/>
        <property type="gene ID" value="EA462_03900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="243" mass="24501" checksum="BAAE131D274C025A" modified="2019-02-13" version="1">MSLVASVSRRAFVGLLLVAAIVTAGLLVSPAAMAGFLESLAADPGLFALTVAGLYLVRPLFAWPTTPLSIVVGYGYGIALGVPIAIVGVVVTVVPVFLAARWFVASNGSSATADSSLETAWGPLDRISGAVTRYYRTTGPIRGVTVSRLAPIPSDVSTCAAALSGVKLRHLVVGTALGELPWTIAGVVVGASAATITTDGFGGLGLALTLACGVAATLLLAGPAYRVVRSRTQTPETGRPGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP31</accession>
    <name>A0A3N6LP31_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fructose-bisphosphatase</fullName>
            <ecNumber evidence="1">3.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91178">
        <property type="protein sequence ID" value="RQG91178"/>
        <property type="gene ID" value="EA462_04080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="268" mass="28721" checksum="094A77330765D75B" modified="2019-02-13" version="1">MTTHGSDRRRADVAVRAAENGAAIAIDSFRTPLEVETKAGKTDVVTDADRNAQVAVTERIRETFPDEPVVGEENDALKRVPDEGPAWIVDPIDGTNNYVDGTPAFGTAVAAVVDGEPVGAALVCPALSDTYRSGPDGAFLNGDPLSVSQRTDPERSIVCPTFWWDFDRRGEYARATRELVTRFGDLRRHGCTQLELGMVASGALQGAVTNLRTNPWDTVAGVGLIRNAGGIVTDLEGERWRHDSRGLVASNGEIHDEVLAAARAIDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPD5</accession>
    <name>A0A3N6LPD5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_04835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91313">
        <property type="protein sequence ID" value="RQG91313"/>
        <property type="gene ID" value="EA462_04835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="5">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="101"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="357" mass="37751" checksum="930CA780E9AD3DDF" modified="2019-02-13" version="1">MDEDAVLERLRSVEDPELGDDIVSLGLVNEIAVDGEAVTIDLALGAPYSPTESDIAGEIRELLLSEGLEPDLTASIPDRDEVSSEEQVLPNVKNVIAVASGKGGVGKSTVAVNLAAGLSQLGARVGLFDADVYGPNVPRMVDADEPPMATEDETLVPPEKYGVKLMSMAFLTGEDDPVIWRGPMVHKVITQLTEDVEWGHLDYLVVDLPPGTGDTQLTMLQTMPVTGAVIVTTPQGVALDDARKGLEMFAKHDTVVLGITENMSTFACPDCGGEHDIFGSGGGEEFAATHEMPFLGSIPLDPSVREGGDGGKPTVLEEGETSDALRSITENVANNTGIVHRRGVSRSTGRRSPSPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPQ9</accession>
    <name>A0A3N6LPQ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AEC family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_05925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91498">
        <property type="protein sequence ID" value="RQG91498"/>
        <property type="gene ID" value="EA462_05925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="302" mass="30889" checksum="9BAEE1F671571CAA" modified="2019-02-13" version="1">MEVVARLLALLVLLLVGAGLRTTGVLDRRRVAGLNTIAYYVALPALVFVSTYDQNVADLLSVALVGGLLFVLGTTAALAWVVHRNRGSNDRSSVAIVQSYHSNLGYLGLPLVAATFDARVTAIASVVLGVVTLTQLPMTIVVLSTLNGADAALVGEIRGIVKNPVLLALIVGLAVGSAGVSIPSTVASGFDAVAALALPIALLCVGASLQVEASTIDFGAVVSVIALKICCMPILAWLVFSALGVDPATFTAAVVMLGTPTAVSTYVFAAELGGDRKFASLNVFATTLASIVTLFVLITLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPY1</accession>
    <name>A0A3N6LPY1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF371 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91593">
        <property type="protein sequence ID" value="RQG91593"/>
        <property type="gene ID" value="EA462_06480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007171">
        <property type="entry name" value="DUF371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023131">
        <property type="entry name" value="Mth639-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40696">
        <property type="entry name" value="PTHR40696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04027">
        <property type="entry name" value="DUF371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="138" mass="14680" checksum="E13EBF1277BD0A47" modified="2019-02-13" version="1">MEEVIHARGHEHVSAAHASTFEVTTDDYLTPAGDCILAIDADRAPADFDPAFVRACRNADATIAVTLEADGHRDSVEGRGDPDLAFESDRSAVGRTSEHVDERTILLEAAFAAEGFDRDLVEALADGADLTVTITVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPY8</accession>
    <name>A0A3N6LPY8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1427 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90277">
        <property type="protein sequence ID" value="RQG90277"/>
        <property type="gene ID" value="EA462_09875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020017">
        <property type="entry name" value="XapX_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03510">
        <property type="entry name" value="XapX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="6792" checksum="62D87C64E50CFBDB" modified="2019-02-13" version="1">MTTQITVLALLTGLLTGALFRFLNIPIPAPPELPGLMGIVGIYVGYRLIDHFDVGVDLLEALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQI4</accession>
    <name>A0A3N6LQI4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89224">
        <property type="protein sequence ID" value="RQG89224"/>
        <property type="gene ID" value="EA462_12730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="70" mass="7889" checksum="ED2D0C4F6EEA7FFB" modified="2019-02-13" version="1">MYSRFNRIIGVFILARASCETVNIDRIRDGTVCPDCDAPLERGHHKDRPALVCRQCGVPRVVSYPVSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRT0</accession>
    <name>A0A3N6LRT0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="2">DHNA-CoA synthase</shortName>
            <ecNumber evidence="2">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">menB</name>
        <name evidence="3" type="ORF">EA462_07680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89884">
        <property type="protein sequence ID" value="RQG89884"/>
        <property type="gene ID" value="EA462_07680"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="140"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="2">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="297" mass="32983" checksum="3A2E972745028E5A" modified="2019-02-13" version="1">MVSELFDEERWTPVDGLERDFRDITYHRAVDSGTVRIAFDRPSVRNAFRPGTVDELYDALEHAKRQTDVGCILLTGNGPSPDDGGWAFCSGGDQTIRGEDGYQYDGDEDRASEQGRLHILEVQRLIRHVPKVVVCVVPGWAVGGGHSLHVVCDLTLASDEHAKFLQTDPDVASYDAGFGSAYLAKQIGQKKAREVFFLGKTYSAEEAADMGMVNEVVPHAELEETALEWGERINSKSPTAMRMLKYGFNMADDGMIGQQVFAGEATRLGYMTDEAAEGRDAFVEGREPSFDEYPWHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS26</accession>
    <name>A0A3N6LS26_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91297">
        <property type="protein sequence ID" value="RQG91297"/>
        <property type="gene ID" value="EA462_04735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="81" mass="8421" checksum="17C92984CDBDCF41" modified="2019-02-13" version="1">MSVRQSFSFVELFLTAPAKSALLGFGPIALALGQLLNSYLNGVSPAVAICFAAVMIGFAVIATGHHAAEVRLQSLEADLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS56</accession>
    <name>A0A3N6LS56_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="7">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ileS</name>
        <name evidence="10" type="ORF">EA462_00285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92708">
        <property type="protein sequence ID" value="RQG92708"/>
        <property type="gene ID" value="EA462_00285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="8">
        <location>
            <begin position="20"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="9">
        <location>
            <begin position="691"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="603"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG92708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1064" mass="121511" checksum="0D1EF741197EFD37" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSZ2</accession>
    <name>A0A3N6LSZ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M10A and M12B matrixin and adamalysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91707">
        <property type="protein sequence ID" value="RQG91707"/>
        <property type="gene ID" value="EA462_04930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="261" mass="28248" checksum="ABD91DB3CDE076C0" modified="2019-02-13" version="1">MNRRHVLGALGTATSLGTLAYATRDPVDTLEIRLWLSERAATYGTARRRVLEYLGRLLDFEFWTVDVSLGGTISVSTEDGALVTSSGEWPLAVTSGTVGPGDIEPASDVNLLVTDGQMRRAPTGYGLPHVASVGGARYLDSLEPFDDLVGTGADGDVERSIVPVRTPTRTMQVLLHEIGHALGLHHDHGVAFRYGDAVVATPMISTYAFDPTYDVDRSRCGTGFATLDDHERRLSLAFSRCARRELRTYTGGIGPRRTIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LU82</accession>
    <name>A0A3N6LU82_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YHS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91104">
        <property type="protein sequence ID" value="RQG91104"/>
        <property type="gene ID" value="EA462_03650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="2">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="363" mass="38020" checksum="AD9AB6C6BD1C29FA" modified="2019-02-13" version="1">MTHDTTPHDESATDAAEGEREDGLESIEDRLVERREPYVRATVVRREPPVSANVGDRAVITADGELRGWIGGASCAQSIVTTEARSVLESGEPQLLGIAPDPERIDRDGLEAFQMTCHSEGVLEVFLESVNTAPDLLIVGDSPVARSLARLASELTFDVTMVSGGGDDGLDGDVPPGTTVRPSTDPDAIVDAIDREPIVVVASMGEFDARGIAAGIMTDALYIGLVASNTRAEEVIERAATVLETDPGAVREAVTNPAGVDVAAYTPAEIAASLLAEIVDVRATVGGATGNYTPADCGAGDGSADREPAIDPVCGMTVVRSDAPATVDHDDVRYYFCCPGCADAFRSDPESYLETTETRVSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWK9</accession>
    <name>A0A3N6LWK9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1931 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006665251.1">
        <property type="nucleotide sequence ID" value="NZ_REFY01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93247">
        <property type="protein sequence ID" value="RQG93247"/>
        <property type="gene ID" value="EA462_03380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015207">
        <property type="entry name" value="DUF1931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09123">
        <property type="entry name" value="DUF1931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="55" mass="6105" checksum="793BDF8F47462D5D" modified="2019-02-13" version="1">MADLIVKAAVKEALDDKNVASDFYDALDEEVDELLADAARRAEANDRKTVQPRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWQ9</accession>
    <name>A0A3N6LWQ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_03175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93327">
        <property type="protein sequence ID" value="RQG93327"/>
        <property type="gene ID" value="EA462_03175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12089">
        <property type="entry name" value="Hef_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041755">
        <property type="entry name" value="Hef_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="PTHR14025:SF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="32"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="363"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="533"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="601"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG93327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="834" mass="92110" checksum="2A0D3E8C603717B2" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXZ2</accession>
    <name>A0A3N6LXZ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86951">
        <property type="protein sequence ID" value="RQG86951"/>
        <property type="gene ID" value="EA462_14940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="37"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="239" mass="24935" checksum="7AEBB035FDBBEA60" modified="2019-02-13" version="1">MSETAVSALLQALSIPLVLTGWIEYILENPGSFATMLREHLQMVVIGVTAAIAVAVPAGIAATRHQAVGTAVMNMGAIAQTVPPLGVIALTFAFLGVGPRPAILALFLYGLLPILKNTTAGIRNVEAAQVEAGRGMGMTRLQRLWRIELPLALPVIIAGIRTTIVLSVGIAYLGAFIGAGGLGQWIILGQQRYANEILLAGAIPGAVLVIVLDQTFGWLGARISPVESSTDDHTQSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYX8</accession>
    <name>A0A3N6LYX8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ring-hydroxylating oxygenase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_14945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86952">
        <property type="protein sequence ID" value="RQG86952"/>
        <property type="gene ID" value="EA462_14945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="53"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="459" mass="51411" checksum="303E126E6AA88DB1" modified="2019-02-13" version="1">MAESTTQSSIPRDVRDVVEDVGRVTETGEIPSRIHNDRDIHEAELERVIGETWVFVGHVSEIPEPGDYAKRYIGDSPFIFVRDETGEIRVLFDSCQHRGTTVVRAEQGNTSHFRCPYHNWTYKNTGELVGVPYKDQCYQELDMCEHALESAPQVDSYRGLVFATISADAPPLSEYLGDFTWYLDLNLGFLEEGFEVVGEPIRWEIDTNWKIGADNFTGDSYHTLATHKSAMDLDIFPPELSATGSDRAPADVTNCSGHSCMLAYLEDGTLTGGYPSEVFSVDGLSSDQFEIARGLVSSVGTVFPNLSFLQMNLNADPDDREVTAFLNLRKWQPIGPKTTQLWNWILVPKTASEEFKQRAYDTGIATFSVSGSFEVDDFAVWDGIAEAAGSTYVTKHRSTSNFQMGIEGMGEATNISEEWPGPGEVYDTNLEDGTMRTFYRSWYRAMTGSRIDPDREDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYY2</accession>
    <name>A0A3N6LYY2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87913">
        <property type="protein sequence ID" value="RQG87913"/>
        <property type="gene ID" value="EA462_13705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="163"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="300" mass="31833" checksum="7913DCA867C2DD84" modified="2019-02-13" version="1">MVNVLGLTFAVLAALALGVTSIFVRLGSRSGKSNEIVIVTFIANLTFVVPITLYWYYPNFGLTPRAIVAFAMAGTMGTFFGRALFYKSIETIGASRTEPIKATQPLHAAVIAALVLGEALTATNLFGILLLIGGLALVSREIVNDDDVGGSDNVSPALLVVPLGAAFFFGIEPIFAKIGFEEDTPILVALVVKTVAGLTAMTLYLRVRNNFPSFSLRSTEPVVLKWYALAGISNTIFLTSYYAALETAPVILVVPLVQTSPLVVVVLSLLFLSHLERVTPRLIAAATIVVVGATVVSLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZY2</accession>
    <name>A0A3N6LZY2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88890">
        <property type="protein sequence ID" value="RQG88890"/>
        <property type="gene ID" value="EA462_10865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036473">
        <property type="entry name" value="Mopterin_CF_MoaD-rel_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="88" mass="9749" checksum="B9A069F05CF96B89" modified="2019-02-13" version="1">MEPSTRIERSFRGISERLAIRYLRNLGGERIDDDVVEGADWRATVSSESVTVGPTLSLTEVTVTFEGTDDDLESLVERFARKAMRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M032</accession>
    <name>A0A3N6M032_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88950">
        <property type="protein sequence ID" value="RQG88950"/>
        <property type="gene ID" value="EA462_11195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="295" mass="32061" checksum="B34D6E4660FC5451" modified="2019-02-13" version="1">MKIAILGCGYVGLELGRQLVERGHDAIGVRRSGDGVRRLEDAGLEAVQADVTDGDDLAAVPDVDAIVFAASSGGRGAGAARAVYVEGLRTAIDAFGARDDPPGRLVYTSSTGVHGDHGGDWVDEETPVEPTTEKTAVLAEAERIALEYPPEYAFEGTVARYAGLYGPGRYRLERYLEGPVTEGYLNMVHRDDAAGAVRFLLSADLARGEVVQIVDDEPAQKWAFADWLADQCGLDAPPKRTKADRLAEEDLSEPARRRILTSKRCSNQKLRTLGYEYSYPTFREGYRDAIEAYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0I5</accession>
    <name>A0A3N6M0I5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89140">
        <property type="protein sequence ID" value="RQG89140"/>
        <property type="gene ID" value="EA462_12270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="297" mass="32075" checksum="0FDB20370BCCC9A6" modified="2019-02-13" version="1">MTHSRLSRRGVVALAAVGLAGCTSSEDRNDDGGTNGGNTDDTNGSESDANGADERDSTDRDIEANWDEAAPFRTWLLDTDANRRFDYTEEFPADADPASGFPDVFGVSDGAIDAHLIQTGTHVFFGSFDSESIVDGVEAADEYDSAGQYEGYALLTQTLPDGQPQDIAIGSDVIVVGNDYERRIDAHRGERDRLEETDPEFTHLFRELPHETTVSGQYGSPTGANVDIDELHLWGVSSEFPTAETMTWVFVFEREEDLTGTALEELEGISSGVEDSSIDGRTATVVGAPPDIPEEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M180</accession>
    <name>A0A3N6M180_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88831">
        <property type="protein sequence ID" value="RQG88831"/>
        <property type="gene ID" value="EA462_10545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="250" mass="29128" checksum="46863DDA8A34C2B3" modified="2019-02-13" version="1">MLDVILDTNYWITLKENQDILSRFKQSKLRHGFNVLFTRPNFVDLAKWDQQDRLSDIIAEITDTYVVVEDYNSDEYLYSDDPLLIPPPEIRDALKEHTLDFRAAKTLRFLFRSMEQNPDEGFPDLSRALSDIHKEGGESYLKMAAFWRYIERKDDRARVELSDASKLGYVRRQLTVEHAKQIQPNENIETQDYVDLEICAYAIYASDVFVGEKKWINQEIIPNVCAGIEDEDGPILMKSLDEFFAGFPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1U4</accession>
    <name>A0A3N6M1U4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89051">
        <property type="protein sequence ID" value="RQG89051"/>
        <property type="gene ID" value="EA462_11775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="408" mass="44557" checksum="A484A1F275A5D3CD" modified="2019-02-13" version="1">MNSATPALLALLLVCSLPAMAIVAADSGLDGSGEPDGSVQDDVPRTPLEIENTTNRLQLGETTHGYAGATPNLGSVFASTDEELRVDHEQYVFVERGFDTASSTEREEMIEAAHSRITDRTAELEEREETVVRQHANGEKSDDELVRSLLEIYHEASVLLDGLDRLEERADDVVGYSLSSNQVRENTRALEAHRTTIKSELAASSADLEADDRFEVLIQTSEEGYRLSIIEGETYISETTRFDNYDPEAPDQFAGTDRDAYDYAGELYPWAAEHGSPNYLAAGSIHDISFTANEFDIRMYIDGGTGEVYRELQRLSIDSLPIKEHETWSQDGLELSTRTTPANGPVEVTVTDAETGEPESSTIAVDGHELGETESDGTLWIIPPIGEYELAAETQTGGINVTTETPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2S1</accession>
    <name>A0A3N6M2S1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90120">
        <property type="protein sequence ID" value="RQG90120"/>
        <property type="gene ID" value="EA462_09005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="221" mass="24250" checksum="630E53AFC04CB7C0" modified="2019-02-13" version="1">MSVQFEKLTFDRLGHATVRVETDDETVIYVDPWGEVLEEETGDGDIVLITHDDFDHYDPAAIDTVSSPAATVAAYEAIDTSDLDFDVVDLPHDGKTMVEGIEIRTVPAYNDPNGAHVDDDGNPFHAEGEVVGLQFTLADATIYFPSDTDFLEHHGSIDADVFVPPIGGHYTMDRNEAAAFARSVDPELVLPEHYDTFEAIETDAEAFAADLSEDGIRVELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2W6</accession>
    <name>A0A3N6M2W6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Replication factor C large subunit</fullName>
            <shortName evidence="4">RFC large subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Clamp loader large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfcL</name>
        <name evidence="7" type="ORF">EA462_09280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the activator 1 small subunits family. RfcL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90170">
        <property type="protein sequence ID" value="RQG90170"/>
        <property type="gene ID" value="EA462_09280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01508">
        <property type="entry name" value="RfcL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023935">
        <property type="entry name" value="Rep_factor-C_lsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="36"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="516" mass="56727" checksum="5C4F5100BE613142" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M332</accession>
    <name>A0A3N6M332_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90250">
        <property type="protein sequence ID" value="RQG90250"/>
        <property type="gene ID" value="EA462_09730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="195" mass="21518" checksum="E6590D613202C4B7" modified="2019-02-13" version="1">MTQTGQGDARTNRGVPDDAVLLLIDFQRGFDDPSWGTRNNPDAERRARRLLEHWRATDRPLAHVRHDSTEPDSPLRGDRPGFAFISETAPVEGEPTFVKSVNGAFVDTDLESWLRSSGYETLVLAGLTTDHCVSTTARMAENRGFDVIVVADATATFDRTFDGERFDPETVHRTALAHLEGEFATVAETDSIVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3D2</accession>
    <name>A0A3N6M3D2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylcholine/phosphatidylserine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90380">
        <property type="protein sequence ID" value="RQG90380"/>
        <property type="gene ID" value="EA462_09460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="241" mass="25030" checksum="D016005AC6EC702E" modified="2019-02-13" version="1">MLPRFVGRLGVADAVTIANAALGFVAVVVAFVDIDLAARLILLAAVADGLDGILARRYGGTEAGPYLDSLADVASFAVAPAVLAFVVVTAGLNIGFETVTAGLLLVTAVCALFVATAVTRLGMYTAYDVTGSYTEGVQTTLAATILGAAILADVAGPWLVLAITGAFCYLMVSRIEYPDLLVRDAAIMGVVHVLAVLVPEFAARSFPFALLILGMAYMTLSPWFYWREGPETGRAGVHGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3V6</accession>
    <name>A0A3N6M3V6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89901">
        <property type="protein sequence ID" value="RQG89901"/>
        <property type="gene ID" value="EA462_07775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="72" mass="7953" checksum="D732F62C7DDCAAA6" modified="2019-02-13" version="1">MNVAGDGGLSVSSQAPSPVDVLDDVPVTNILYMMLELGYELPDLDSLLLWSSRDPNPHRPRLREQVESYGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4T4</accession>
    <name>A0A3N6M4T4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90251">
        <property type="protein sequence ID" value="RQG90251"/>
        <property type="gene ID" value="EA462_09735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="13106" checksum="84E7A7D39CA69FF7" modified="2019-02-13" version="1">MTDEGSDRPAIVSEGRYSIVDASAGEPTDFWLVRADTESRDSGGVEVDVAHRVPIDDTEIDDLDSTISRFRNTRSDTTDGTDQVELECHECGKRWTYTGSDDHAACPNCETEVPVKGIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M596</accession>
    <name>A0A3N6M596_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl13</name>
        <name evidence="5" type="ORF">EA462_04155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91190">
        <property type="protein sequence ID" value="RQG91190"/>
        <property type="gene ID" value="EA462_04155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_L13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="PTHR11545:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="147" mass="16439" checksum="26C615212255BEA4" modified="2019-02-13" version="1">MSVAEFDADAVIDARDCILGRVASEVAQRALDGERIAIVNAEDAVITGDKEDVFETYRTRLQMGSDSGPYYPRRPDTIFKRSVRGMLPYKKPRGREALDGVRVYVGNPYEGDRDAEIVEDTSLDRLSNIRFVHLGEVSEQIGANVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5V0</accession>
    <name>A0A3N6M5V0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ORF">EA462_05355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91400">
        <property type="protein sequence ID" value="RQG91400"/>
        <property type="gene ID" value="EA462_05355"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="4"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="220" mass="22816" checksum="9E13E42341A8353F" modified="2019-02-13" version="1">MTRVKICGLTGRNDLETVVDAGADAVGVIVDVPVNTPREITADRAADLVATAPPFVTTVLVTMDRGLEHAADLVERVEPDVLQLHADPETIDIAAVTDCVDSQLVLAVDTDDVSSAQRHDGDVDAFLVDTPAEDGGGGTGRTHDWNRTRTAIADLESPVILAGGLTPANVAEAVRAADPFAVDVASGVEADGGVKDPNAVRSFVECARRAHGAEPTPHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M606</accession>
    <name>A0A3N6M606_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_05710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91460">
        <property type="protein sequence ID" value="RQG91460"/>
        <property type="gene ID" value="EA462_05710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="28192" checksum="EAB57C046E45EF8A" modified="2019-02-13" version="1">MEDDTDPTGDAETEPGDDGGRIPVLLVRDDREFLIEPGEEMGTDLGVLDVPDDVESGDTIPTHLGEAFTVRRLRGPDLFHHFERTGAPMVPRDIGLVIGETGIARGDRVLDAGTGTGVLAASMARAGASVVTYERDPDFADVARTNMALGGVTEDVDVRTGDVREEIETLEPSSFDVLTLDTGDAASIVSHAPDLLVEGGFVAVYSPFIESTRAVVEAAREVELSNVRTRETIQREMQFDDRGSRPSTAPVGHTGYLTIARNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M687</accession>
    <name>A0A3N6M687_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylosuccinate lyase</fullName>
            <ecNumber evidence="3">4.3.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88796">
        <property type="protein sequence ID" value="RQG88796"/>
        <property type="gene ID" value="EA462_10345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006188">
        <property type="term" value="P:IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013539">
        <property type="entry name" value="PurB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08328">
        <property type="entry name" value="ASL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C" evidence="2">
        <location>
            <begin position="336"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="461" mass="50708" checksum="B2567C593A2AD10E" modified="2019-02-13" version="1">MTDTHALYAVSPLDGRYGRRTEPLSPYASEAALMRARVRVEVEYLIALSDLEATPLSLDSDERGTLRELYEGFDEDDAALVKKLETDGHAGFDATNHDVKAVEYFVRHRLPEDSDASPWIHFGLTSEDVNNLAHRLLVRDAVDDVLLPALYDVRDALAEMAREHRDLPMLARTHGQPATPTTFGKEMAVYAARLGRATGRIRGATDGLRGKLGGASGTYAAHVAAYPNVDWQAFAERFVTDLGLGFESLTTQVSPCDDLAALFDAFRGANDVLLDLDLDIWLYVSDRYLGQEAVDGETGSSTMPHKVNPIDFENSEGNLSKANSDLTFLADYVTTSRLQRDLSDSTVKRNIGAAFAHCLIGYDKTAVGLAKVVPTETVMRDDLESTPEIIGEAVQTILRREGQEDAYERVKDVTRGKDVALADFREMFDDLEVDDDVREELHALTPTGYTGVASGLVDNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M727</accession>
    <name>A0A3N6M727_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_12300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89146">
        <property type="protein sequence ID" value="RQG89146"/>
        <property type="gene ID" value="EA462_12300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="168" mass="18085" checksum="CF5459139A805B09" modified="2019-02-13" version="1">MNIGIVSDTHDNVTATERVTEIFAAEGVEIVLHCGDFVAPLIPPYFEGVELHGVLGNNDGDVANLGSAFDALSGESELHGRFASLEFDGLSFAVLHGESKAEVEAVATAGMYDFVCYGHHHERELTEVGRTTVLNPGAHFPTVADADRTVAILDTRSETVRFRSVLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M794</accession>
    <name>A0A3N6M794_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_12740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89226">
        <property type="protein sequence ID" value="RQG89226"/>
        <property type="gene ID" value="EA462_12740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="27"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="360"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="403"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG89226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="612" mass="66426" checksum="6A43A01B13CE73BC" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7R5</accession>
    <name>A0A3N6M7R5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91381">
        <property type="protein sequence ID" value="RQG91381"/>
        <property type="gene ID" value="EA462_05245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="123" mass="13720" checksum="7363E56CAC4DBA85" modified="2019-02-13" version="1">MATSDSSGDGFQTATVSSGNYDGDDAEWIPLPDEGEVIQGIILAMTPNSGDYDQLRVRFKSTDGDDEGEIRLAHFNQTLEDTVHENGISEGYEFRLEGVDSYEWTDDDGNEREGTERELEYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8X0</accession>
    <name>A0A3N6M8X0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hisI</name>
        <name evidence="9" type="ORF">EA462_00240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92700">
        <property type="protein sequence ID" value="RQG92700"/>
        <property type="gene ID" value="EA462_00240"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG92700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="125" mass="13881" checksum="D65E451E6DD8D54E" modified="2019-02-13" version="1">MDDGIAIDFGEDGLVPAVAQDAETGDVLMLAYVSPEAFERTRETGRAHYYSRSRDELWEKGTTSGHIQNVEEVRVDCDADTLLYLVDQEGGACHTGYRSCFYRTVEGETVGERVFDPEAVYESGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M926</accession>
    <name>A0A3N6M926_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RecJ like exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89986">
        <property type="protein sequence ID" value="RQG89986"/>
        <property type="gene ID" value="EA462_08240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="634" mass="70183" checksum="40F4FE65F8E2F779" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M941</accession>
    <name>A0A3N6M941_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coenzyme F420:L-glutamate ligase</fullName>
            <ecNumber evidence="8">6.3.2.31</ecNumber>
            <ecNumber evidence="8">6.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Coenzyme F420-0:L-glutamate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Coenzyme F420-1:gamma-L-glutamate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cofE</name>
        <name evidence="10" type="ORF">EA462_00685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + L-glutamate + oxidized coenzyme F420-0 = GDP + H(+) + oxidized coenzyme F420-1 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:59907"/>
            <dbReference type="ChEBI" id="CHEBI:59920"/>
            <dbReference type="EC" id="6.3.2.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + L-glutamate + oxidized coenzyme F420-1 = GDP + H(+) + oxidized coenzyme F420-2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30523"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57922"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:59920"/>
            <dbReference type="EC" id="6.3.2.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="8">Monovalent cation. The ion could be potassium.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CofE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.31" evidence="8"/>
    <dbReference type="EC" id="6.3.2.34" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92780">
        <property type="protein sequence ID" value="RQG92780"/>
        <property type="gene ID" value="EA462_00685"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052618">
        <property type="term" value="F:coenzyme F420-0:L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052619">
        <property type="term" value="F:coenzyme F420-1:gamma-L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01258">
        <property type="entry name" value="F420_ligase_CofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023659">
        <property type="entry name" value="F420_ligase_CofE_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="38"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="210"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG92780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="258" mass="28006" checksum="3E5CB9880BB70610" modified="2019-02-13" version="1">MELEPVTDVPEIRPGDDIAALVADRATLEPGDVLTVASTIVSKADGRTADLEAYPVSGRAREIADRIGALTDDEKDPRFAQAVLEESTELLIDCPFLLTETRFGHICVNAGIDRSNVPDHDLLLLPDRPAKSAERIRTGLVDRGIDDVAVIVTDTCGRPFRHGQRGVALGWAGMPASRDWRGELDRDGRELGVTVQSVVDELSSAANLVAGEGAGGTPAVVVRDWEFGDVAGSDELFRSVEDDLIRRALRQWEWGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9B5</accession>
    <name>A0A3N6M9B5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90106">
        <property type="protein sequence ID" value="RQG90106"/>
        <property type="gene ID" value="EA462_08905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="156" mass="17317" checksum="89452AA9871FB8B0" modified="2019-02-13" version="1">MKTVQDDTGKRYLLLKQSEHASLVRDPQNGNECYVRNDRLETVDDATALETAARTIPDPHRRLLTTVHDEETLGLLIELSERGPIDVRTLLDRYTLCESDLHGRLTVLTSAGLLAETAVAGEPAYQLTESCRTALETFRTGPIVDSPSETRLEGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9C0</accession>
    <name>A0A3N6M9C0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92880">
        <property type="protein sequence ID" value="RQG92880"/>
        <property type="gene ID" value="EA462_01255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="170" mass="18016" checksum="460222AF30492FB3" modified="2019-02-13" version="1">MAKYSTGSSSGGGGTNCELCGAESDSLRLASVAGAELEVCPGCAPHDDTADRERSDRDSSGSSTDGPSRKQKAARNVAKANPVWDGDSEHWEQDGTNYDDDPLPYLVSEYGERVVDARQEAGLQREELADELGLREQELLAVEQGRATQAGIGGGVIEALEDRLDVSLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9P0</accession>
    <name>A0A3N6M9P0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90256">
        <property type="protein sequence ID" value="RQG90256"/>
        <property type="gene ID" value="EA462_09760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="193" mass="20504" checksum="A182AE5B805226C6" modified="2019-02-13" version="1">MSGTQITVYVNRGTTDSLEAETESIETHRTFTLDLQGYERPAHVHCRILGDLDRIVSIDQSNYYLEPGVETGVPVEIDSARIDEPVDGQLEIVTGYGAESLTIDLTVTPAPDTGIDVDRSLSKPSRPTPEPSPFEQLFSRLVLDTSAIAVLALGAIAVAIATITAATIGGLMALIGLAIVGAGVLVALWLLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9U0</accession>
    <name>A0A3N6M9U0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional nuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93070">
        <property type="protein sequence ID" value="RQG93070"/>
        <property type="gene ID" value="EA462_02365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="155" mass="16768" checksum="BCF6B9C4FB98555E" modified="2019-02-13" version="1">MQASIDAVRVAGTQQGPVPVVVLEVDGEDDVVPIFIGFNEATSIARGLEAEDIGRPLTHDLLLDVMEELGSRIDRVVVTEIETRDDGHGGTYIADLHVQTPRGETVIDARPSDSLALAARTNAAIEVSSDVFENGRDDSEKFEQLEDIRTVSGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MA38</accession>
    <name>A0A3N6MA38_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93190">
        <property type="protein sequence ID" value="RQG93190"/>
        <property type="gene ID" value="EA462_03040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="110" mass="12931" checksum="32F344824D529131" modified="2019-02-13" version="1">MSVEQRPVDSPPTDERAKNPRYGIELEFRSTDTDSSADRVERTLAVRIERVRLLARIAALERELEECEKRRQEIITRYERVLEDQRADADRGETRTNAPDPLGRLRRIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBE3</accession>
    <name>A0A3N6MBE3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5,10-methylenetetrahydromethanopterin reductase</fullName>
            <ecNumber evidence="4">1.5.98.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Methylene-H(4)MPT reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mer</name>
        <name evidence="7" type="ORF">EA462_00690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:21144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57818"/>
            <dbReference type="ChEBI" id="CHEBI:58116"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
            <dbReference type="EC" id="1.5.98.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mer family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.98.2" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92781">
        <property type="protein sequence ID" value="RQG92781"/>
        <property type="gene ID" value="EA462_00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018537">
        <property type="term" value="F:coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01091">
        <property type="entry name" value="F420_mer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019946">
        <property type="entry name" value="MeH4methanopterin_reductase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="342" mass="36480" checksum="E3B6DB352C5250FD" modified="2019-02-13" version="1">MTNDGPDGVSVRGSSEPTRAIELTPEHPPARIAELAACAEREGFDVAFTSSHYFNRDPFVTLSRMTDATDEIRLGPGVVNPYETHPVKLAAQTATIDEVSDGRAVFGVGAGDRSALSNMGVERDRPLRRVLETFDVARDLWDGTTVTHEGTFTARDASLNLEPAEIPVYVGAQGPQMLRMSAKHADGALINAAHPRDLEWASDQIERGLEDRPDEHGEFEALAFASVSVAPEEDDARAAARPPVAFIAGGAADPVIDRHDIDRQAASAVSDALEDGRLTEAFDRVTPEMIDAFCIAGTTETVADRFEAALEHTDGIVVGSPLGPDLEDAIVRASEALSIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFI4</accession>
    <name>A0A3N6MFI4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit Rpo1C</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit A''</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rpoA2</name>
        <name evidence="3" type="synonym">rpo1C</name>
        <name evidence="5" type="ORF">EA462_00045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92666">
        <property type="protein sequence ID" value="RQG92666"/>
        <property type="gene ID" value="EA462_00045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06528">
        <property type="entry name" value="RNAP_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00411">
        <property type="entry name" value="RNApol_arch_Rpo1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012757">
        <property type="entry name" value="RPO1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02389">
        <property type="entry name" value="RNA_pol_rpoA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb1_5" evidence="4">
        <location>
            <begin position="57"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG92666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="405" mass="44523" checksum="086A04DC3FAB1A95" modified="2019-02-13" version="1">MTEVDFDVDDDTIAIVENADLPRRLKDEVYAELESRPEATVEDADNLANAVEDRYVDTRVEPLDPVGTVSAQSIGEPGTQLTMNTFHYAGVAEIDVTQGLPRLIELVDARKTPDTPMMTVHLEDEYATERENAHEVVWNIEATKILALGDVSTNVADMRVQISLNQDTLEERMITPEEVAEIIEDNLGVSTVQNGTEVQFGPEEPSYRDLLQLVEELRDITFKGIEEVSRVVIRREEREAGTPSDGDDGSEEFVLYTEGSAFGDVLEIEGVDASRTTCNNIHEIHRNLGIEAAREAIIEETNNTLAEQGLDDVNVRHLMLVADIMTNRGEIESIGRHGISGSKESVLARAAFEVTVNHLLNAAIHGEIDELHGVTENVIVGKPIKLGTGDVELRMGSTTGGRQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGX2</accession>
    <name>A0A3N6MGX2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93236">
        <property type="protein sequence ID" value="RQG93236"/>
        <property type="gene ID" value="EA462_03310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042150">
        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35797">
        <property type="entry name" value="PTHR35797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="306" mass="31811" checksum="121F951785BE0BB8" modified="2019-02-13" version="1">MTDRRPLFVFLGSLIVLSSGFVFVSQLLSVSMITLAPAYMFTPMFAGIVTCLAGSPSFERAGLRIPWGRLRWLGAAALAPIALILIGTGLALALPEVQFVPDANPLTGEGTEFAPANGDGAAGPSLPGWPLNLILTAVAALVLGVSINAVFAFGEEFGWRGVLLTQLAPYGFWQASGAIGVLWGVWHAPIILEGYNYPNNPVVGVGVMTFACLAMSPVYTYLTIATRSVLSAAVFHGTFNAFATTMIVFARGGSELVVNPVGGVGIVVFGLAALGIAIRGTPELTADWAVGRDESVADPDGSTHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MQN9</accession>
    <name>A0A3N6MQN9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86139">
        <property type="protein sequence ID" value="RQG86139"/>
        <property type="gene ID" value="EA462_16845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="121" mass="13783" checksum="AC8FECB7240004A4" modified="2019-02-13" version="1">MDNHGNWWPSTVYDLLSNSRRRLVLYSLLDGDNATIDELTREIALTEGRATDEDVMEEIEISLVHNHVPRLVDHGIVEYDGRDDRVELTKRFDDIQAAVERSKEIEVDGVPATQSEVFSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MR28</accession>
    <name>A0A3N6MR28_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Formate dehydrogenase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EA462_16265</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86693">
        <property type="protein sequence ID" value="RQG86693"/>
        <property type="gene ID" value="EA462_16265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015942">
        <property type="term" value="P:formate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02753">
        <property type="entry name" value="MopB_Formate-Dh-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041924">
        <property type="entry name" value="Formate_Dh-H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006478">
        <property type="entry name" value="Formate_DH_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01591">
        <property type="entry name" value="Fdh-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="12">
        <location>
            <begin position="142"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="11">
        <location>
            <begin position="396"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="301"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1087"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG86693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1108" mass="119030" checksum="176771B50FEC8948" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MT22</accession>
    <name>A0A3N6MT22_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87925">
        <property type="protein sequence ID" value="RQG87925"/>
        <property type="gene ID" value="EA462_13770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="264" mass="29896" checksum="4F6C16DC7339DD6A" modified="2019-02-13" version="1">MPKSITVDRVSKTYGNGEEAVHVLDDISISIPEKEFVCILGPSGCGKTTLMKMMDGLVDPSEGEIRIGDTVITEPTPEAALVFQNFELFPWRTTLENVELGLEILGVDKSTRRERAQTWIDRVGLDGFEESYPSELSGGMQQRVGLARALCVDPEVILMDEPFGALDAQTKDKMQTQLLQLWEQEKKTVVFVTHDIRESIFLADRVLVMGTKPSSIVEDIEIPFERPRWKRRVEIENDDRFADIEQLLRERLGLKAEEETEVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MU82</accession>
    <name>A0A3N6MU82_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin-like protein CetZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cetZ</name>
        <name evidence="7" type="ORF">EA462_11205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in cell shape control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CetZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88952">
        <property type="protein sequence ID" value="RQG88952"/>
        <property type="gene ID" value="EA462_11205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01946">
        <property type="entry name" value="CetZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032907">
        <property type="entry name" value="CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="2"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="10"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG88952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="360" mass="38080" checksum="11BACF6716F8E146" modified="2019-02-13" version="1">MKVALIGIGQAGGKVTERLTRFDANMGFEAVQGALALNSAKPDLQSIEFVDTQLIGADRVNGHGVGGDNELGSEIMQSDVQEVLGALDGRITSRSDAIVVVAGLGGGTGSGGAPVLVHNLQQVYDVPVYALGILPGRNEGALYQANAGRSLKTLLREADSTLLIDNDAWHEQGESVEDAFETINDKIAQRVGLLFASGEIIDGVGESVVDSSEIINTLRSGGVSVLGYASEVASEDSSENIRTVMTVARQALLTGASMPDATAADSALLVIAGQPDRIPRKGVEKARRWLEDETESMQVRGGDFPLESERLGALVLLGGAERSERISAFMDRAREANKTQQSEATDTIDDLTDDRLENLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MV10</accession>
    <name>A0A3N6MV10_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalt-factor II C(20)-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.151</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.151" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89252">
        <property type="protein sequence ID" value="RQG89252"/>
        <property type="gene ID" value="EA462_12880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043781">
        <property type="term" value="F:cobalt-factor II C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="271" mass="28724" checksum="3285CD80F60391BD" modified="2019-02-13" version="1">MTLYGVGLGPGEADLVTVRGKEVLRNADTVYSPGRLSRTVAIEHVDESKIGNLDFPMTKDEEKLRSAWKEAAAAIAPNALDGDVAFVTLGDPNVYSTFGHLRRTVTAFHPDVDLEIVPGVSAVTAFATALDVEIEAGAGLSLREAANGVSPAGPDRMILFKVTDAPATHEGLVEAGYDVTYGRRLFMEQGETVVTDDPDAIDERDYYTLAYAERNDLAEQATAVFGRETGDSPESTSEDSAPSDTSAADGGTAVELERAEGCEHGDCGGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MV19</accession>
    <name>A0A3N6MV19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain-containing sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89262">
        <property type="protein sequence ID" value="RQG89262"/>
        <property type="gene ID" value="EA462_10440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="128"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="338" mass="37626" checksum="4DF4E538408C1327" modified="2019-02-13" version="1">MLPAEFDNLDVGITLHDSETGAVLDVNEELEKLYGYSRAELRSMTVGEYTAPSTRFTQEKALDRIRAAAAGESQVFEWHVERSNGELLWVSVHLSETVLDGVSCVLAEVYDITDFKARERRLRLLSRVLRHNLRNEMTVLRGYAELLTEAIEEETLEEQAETIFEIATEVGELSDSIRQIEEIATPDATKRSPTNLRDVVVSVTGTVPDEYPETDLSVETSEDVWVVADRSIRYAITHAIENAIEHNDRESPTVSVTIDDDPEAGRGVVRIADNGPEIPNVEIDVLDENTDPNEVYHGSGVGLWVMKWCVDSLGGSLEFESNSPRGNVVSISLPRVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MV26</accession>
    <name>A0A3N6MV26_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_11105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89272">
        <property type="protein sequence ID" value="RQG89272"/>
        <property type="gene ID" value="EA462_11105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="514" mass="53817" checksum="5415E2C75F2B9A5B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MZS1</accession>
    <name>A0A3N6MZS1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91102">
        <property type="protein sequence ID" value="RQG91102"/>
        <property type="gene ID" value="EA462_03640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="496" mass="53460" checksum="F69C9567EEA215F9" modified="2019-02-13" version="1">MSPPGDFDATEAIDGVERSIASDSTSRTERRNDDDDAVARFGAGRSRSDHGVPDFVGARQHVLTELVRFASALRSEGVAVPPTGTLEAARSLSVIGLADESRASAALRATLVTEADEREAFDAAFPTFWHRLRTGLERIATANDWTSPDGEDDEGAIDPDQDRSESPRDADFLNDADAPPMDAENSGDEDESVPSVRIATNRREVSGDRSASTEESEVRRYSSVGGSQPVDAEIHPLSRGERTSIRRFVDALATLPGRRSRTSPSGSAVDARRALRSSLGTGGAPIELPATEAIRSELRCCLLVDVSGSVLDTIDRSVLLTFAEYLQESARDARVFLFDTDLVDATAEFARADGDPAATLRDAEVEWGGGTRIGAAIASLRRRHPNAVDRRTVVVVVSDGLDVGDQELLETQITWLASRADSFIWLNPLAASPAFEPRSRGMATSVPYVDALFGFVAPSDLESAARQIERRGLDGPIGYEYDPRRRPTESGGEKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3P1</accession>
    <name>A0A3N6N3P1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92752">
        <property type="protein sequence ID" value="RQG92752"/>
        <property type="gene ID" value="EA462_00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="94" mass="10765" checksum="8E49CA4AA7F077F7" modified="2019-02-13" version="1">MFIEPDRLESRLREEFGGGSSESRVVVRQAVDLADSCLYVDDVGSPLTNDVVIEELSDAREGTPAARWNWWIGSLDVAFGHYHQFSVRRYPYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N442</accession>
    <name>A0A3N6N442_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <shortName evidence="8">GAPDH</shortName>
            <ecNumber evidence="8 10">1.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gap</name>
        <name evidence="12" type="ORF">EA462_01545</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8 10">
            <text>D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8 10">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.59" evidence="8 10"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92932">
        <property type="protein sequence ID" value="RQG92932"/>
        <property type="gene ID" value="EA462_01545"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00559">
        <property type="entry name" value="G3P_dehdrog_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006436">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01546">
        <property type="entry name" value="GAPDH-II_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="11">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="8">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="8">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG92932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="355" mass="38292" checksum="440BEF62BC4E52DB" modified="2019-02-13" version="1">MLRVGVNGYGTIGKRVADAIRAQPDMVVCGVAKRSPDYVAVGAAEESYPVYAVDGERTEEFRSIGIDLAGTVDELVDESDVMVDATPSGVGADNRSLYERHDTPALFQGGEDATVAEVSFNARVNYEEATGADYARVVSCNTTGLSRFVAPIEENYGIEKARATLIRRGGDPDQTGRGPINDAVPDPVSIPSHHGPDVQTIFPDLDIDTIGLKVPTTMMHVHAVNVTLEEAPDDVSEIRDRLRAEDRLVLIPEYAGIDGAGTLKDFALDAGRPRGDIWENCIWEESLTLEGSDLYCMQAIHQESDVVPENVDALRALSGHLSGPESRSLTNETLGIGLGRLDGREDLTLDRQTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUA3</accession>
    <name>A0A3N6NUA3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IIA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86730">
        <property type="protein sequence ID" value="RQG86730"/>
        <property type="gene ID" value="EA462_16470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="259" mass="27508" checksum="E67B2F75672C83C2" modified="2019-02-13" version="1">MDGAIIDLDGTVYRSNEPIPGAVKAINRMRSFDLDIVFATNSSTKSIRTCVEKLESMGVSTNRNEILTSASVTASYVSEAYSDAVAFVIGEDPLRDELSERGVAISSDPCDAETLVVGKDRSFDFNTLQMTLNILDTGIPFIVTNPDRSSPTDSGIAPGTGAIIAAIVAASGRDPDIVVGKPNESMANITLDSVDSSPSEWLVIGDNVDTDIAMGKRAGMTTVLVQSGVDNRRVERNSSTLPDYILDSLGSINEVLNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVH1</accession>
    <name>A0A3N6NVH1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_13260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87832">
        <property type="protein sequence ID" value="RQG87832"/>
        <property type="gene ID" value="EA462_13260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="11"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="334" mass="35290" checksum="7485FEF658ED3A63" modified="2019-02-13" version="1">MRAVQVESAGGSFDCVDRERPAPGDGEVRLEVEACGVCHSDSYVKEGNWDGITYPRIPGHEIVGRVDAVGSDVETWEPGTRAGVGWHGSHCFTCDPCRRGRFINCRHEQITGIDRDGGYAEYVVASAEALARVPEELDSTAAAPLLCAGVSTYRSLQLADTRDGDVVGIQGIGGLGHLGIQFASAAGFETVAISRGTEKRELAHALGADHYVDARSRDPGDELANLGGASVVLATAPNSRAIQSVVSGLGVGGELITLGVPDESVDVDVLELIDNQRSITGWSSGTAADSEDALAFSALHDVAPKVERYPLEEADVAYDRMKSGDARFRVVLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVR6</accession>
    <name>A0A3N6NVR6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87972">
        <property type="protein sequence ID" value="RQG87972"/>
        <property type="gene ID" value="EA462_14030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="144" mass="15869" checksum="1C819D5060C1F2B0" modified="2019-02-13" version="1">MSTHVLVPIDRSECSTRALEFALKTYSEKRITAITVTDPSDVYDTPAFESTSARSTEQRRQKHERRARTVLEDARELATDAGIDLETDHVIGGVSKTIIDYADEHDVDHIVVGSHGRTGASRILLGSIAETVARRSPVPVTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVU8</accession>
    <name>A0A3N6NVU8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88022">
        <property type="protein sequence ID" value="RQG88022"/>
        <property type="gene ID" value="EA462_14295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="223" mass="24916" checksum="EB0822428704D1CD" modified="2019-02-13" version="1">MGKPGQKVARVIDDYELEGLDETLVDLWTRDDSSRKSIRELADLVNAEIVSAVVGSELQGMTPMEYPPDRIATRLAARSSTDSRFEDVSQGDINEVTNWMESEGIDVDSLTNDFVTFGVVYDYLKNYHDAKASEKYRKSSSPEELKEKVTSRLDGLKEQVETVTKESNRSLENAGILQETNRTVTVDIRITCVNCGREYPAIEFVEANGCRACDDELTGPVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWC1</accession>
    <name>A0A3N6NWC1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88819">
        <property type="protein sequence ID" value="RQG88819"/>
        <property type="gene ID" value="EA462_10470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="95" mass="10984" checksum="DBFDCEA4ABC12A06" modified="2019-02-13" version="1">MDQLTGFQRDLLYVIAGKDRPSGQQILDDINGYIDQPVTHGRLYPNLDTLVDKELVEKGQLDRRTNYYALTPKGKRELQHRQEWVGQYVDVVGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWN2</accession>
    <name>A0A3N6NWN2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor IF-2 subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_11305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88969">
        <property type="protein sequence ID" value="RQG88969"/>
        <property type="gene ID" value="EA462_11305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="PTHR10602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="SSF110993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="SSF116742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG88969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="266" mass="29514" checksum="3B5264BEA5992AC4" modified="2019-02-13" version="1">MKFSGWPDAGELVVGKIDEIEDFGVFVDLEEYEDKRGLIHISEVASGWIKNVRDHVREGQIVVCKVLDVDEGHEQIDLSLKDVNDHQRSEKIQQWKNEQKADNWMDLAVGEEIDDEEYTAIATELIGVHGSLYDGFKQAAIHGEEALSDTDLSADEIDAIVETARENVSVPYVTVTGYVDLENPSPSGVDGIRKALEAGQGNGDIPDEIDLEVSYVGAPEYRIKVKAPNYKTAESQLEASADRAVTTIESHGGEGEFHRERRTDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWY6</accession>
    <name>A0A3N6NWY6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89119">
        <property type="protein sequence ID" value="RQG89119"/>
        <property type="gene ID" value="EA462_12160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045490">
        <property type="entry name" value="DUF6432"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20024">
        <property type="entry name" value="DUF6432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="99" mass="11198" checksum="734562B9928DE2A2" modified="2019-02-13" version="1">MRAKREYRDRSETEVAVLDALVDRAGDGMTVFELRAAVEAEIDDLEDALATLKSDGLIVVESEGDRTRIKPDERVVPSDPTDLDEESSISDWLRERFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NY84</accession>
    <name>A0A3N6NY84_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dodecin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89759">
        <property type="protein sequence ID" value="RQG89759"/>
        <property type="gene ID" value="EA462_06995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324">
        <property type="entry name" value="PTHR39324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="66" mass="7429" checksum="F82CBC5FE53E1389" modified="2019-02-13" version="1">MVFKKITLIGTSTESFDAAADDAIDRAEETLQNVYWIEVDELGVEIASVENREYQAEVTVAFELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NY98</accession>
    <name>A0A3N6NY98_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
            <shortName evidence="1">HPPK</shortName>
            <ecNumber evidence="1">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">6-hydroxymethyl-7,8-dihydropterin diphosphokinase</fullName>
            <shortName evidence="1">6-HMPDK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">7,8-dihydro-6-hydroxymethylpterin diphosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
            <shortName evidence="1">PPPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mptE</name>
        <name evidence="3" type="ORF">EA462_07100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal 6-HMPDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89779">
        <property type="protein sequence ID" value="RQG89779"/>
        <property type="gene ID" value="EA462_07100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02131">
        <property type="entry name" value="HMPDK_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027510">
        <property type="entry name" value="HMPDK_MptE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648">
        <property type="entry name" value="PTHR39648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MAF_flag10" evidence="2">
        <location>
            <begin position="46"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="239" mass="26266" checksum="09FDA4BC2CC76D7D" modified="2019-02-13" version="1">MNFAEWESVYVDILEDFGYDRVADERARDVLGSLTGPFDTDRLSMARGATVAIAGGAPSLEETGQLERVRCADVVFAASTAADVLETNGVGVDCMVTDLDKNPVTVRLLTERSVPAAVHAHGDNIPAVRRTVPDCVDEFVLPTTQASPNGPVRNFGGFTDGDRAAFLADSLGADRLVFAGWEFDDPTVDQLKANKLAWAERLLYWLERRREERFDVLDGRRDAIESIGAFETRSSDRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYR8</accession>
    <name>A0A3N6NYR8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90009">
        <property type="protein sequence ID" value="RQG90009"/>
        <property type="gene ID" value="EA462_08360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043814">
        <property type="entry name" value="DUF5796"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19109">
        <property type="entry name" value="DUF5796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="167" mass="17864" checksum="69CA5DE424C9D2FC" modified="2019-02-13" version="1">MSARNNVAPSTIGVDFVEGGVVVEYLDGREVFYHGPPKPVEGPITTPPGKDVHVLVTDPEGIEGVMTYVNDRDTHDGILETTGVGRVMLDGSDEERLFPGVTVSTDAYSIRVEADHSSVDGRVFVFAEDEMSEHAYELVDESADGGGSSETRGSRSSGDASREESRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYV6</accession>
    <name>A0A3N6NYV6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Triosephosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90059">
        <property type="protein sequence ID" value="RQG90059"/>
        <property type="gene ID" value="EA462_08650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="226" mass="24174" checksum="6674A63204C6E6E8" modified="2019-02-13" version="1">MTHTYPYFGVNFKVYPNTIGEGGLELAKTVERVHEETGANFVVTPQIPDLRLITSETDLTVSSPHVDPVSPGRGIGKVLPETLADAGIAGATINHAENRDTLTDIAKKIDRCNEVGLDSSVCVDSIEMGEAVAAFDPDALIYEKPEDISTDRAITTTHPERVERFVEMIESTNPRTKVLVGGGIRTAEHVRAAFELGADATGAASAISTADDPYERLTEIAGALPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ63</accession>
    <name>A0A3N6NZ63_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylated-DNA--[protein]-cysteine S-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.63</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_09430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90199">
        <property type="protein sequence ID" value="RQG90199"/>
        <property type="gene ID" value="EA462_09430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="4">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="156" mass="17226" checksum="E8929089E4771DEC" modified="2019-02-13" version="1">MEDVTEAGIYGRKSSYLDRYVQLGAASGRVISVSFPDVPEDELDDDHPVLELLFEYLDGLEPVVFDDVTVALTMPTDQRAVLEQVGEIPYGDQVDVETLARTVPDLDPDDDDDIILIRTALDENPAPILIPDHRVRDGPSAAPPAVEQKLRSLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZL3</accession>
    <name>A0A3N6NZL3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endonuclease III</fullName>
            <ecNumber evidence="9">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">nth</name>
        <name evidence="11" type="ORF">EA462_15285</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87006">
        <property type="protein sequence ID" value="RQG87006"/>
        <property type="gene ID" value="EA462_15285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="10">
        <location>
            <begin position="44"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG87006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="227" mass="25233" checksum="46ADEE8D86BBA47B" modified="2019-02-13" version="1">MGTPLASTGEQAEEVVNRLEEAYPDSTISLRYADRLELLIAVILSAQCTDERVNSETEHLFEKYDGAKDYANVPQDELAEDLNSITYYNNKAKYIRSACESIVEDHDGEVPDTMAELTDLSGVGRKTANVVLQHGHDVVEGIVVDTHVQRLSRRLGLTEEEYPEPIEAELMEIVLEDYWQQFTHLCIDHGRATCTARNPDCSACVLADICPSEKGDGEVDLASGDPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P198</accession>
    <name>A0A3N6P198_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88835">
        <property type="protein sequence ID" value="RQG88835"/>
        <property type="gene ID" value="EA462_10565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="265"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="322" mass="36820" checksum="4E348E5571559191" modified="2019-02-13" version="1">MTFSVSWHTLLDELDDLPEGATLITPLSHKRFRVTDVQEQRVIIDFEDRDEKRPLQRDQFETLYRRISDGHGGFELDRLPADADPYPAVLSLHPRFEIDEDAGLIIEKDGPTSSQLLDAELTRDTDERSEPDLDVYADALLLVDALERHDVTTLSEMETNALVNLYTLLSDVQRNANDLRQDVAGVLLNRLHHDRPVSGPFGSVQRTTRRNRSLKDEEEVLAKLENAGVDRERVTGIDRSKVDDALKVTELSERDVYDIEESEYVRKAEVDEEVKETRLQGLKEQLAATEGEEAEELRQEIEDLEGRIDELTSFRTGTEVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1B4</accession>
    <name>A0A3N6P1B4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88855">
        <property type="protein sequence ID" value="RQG88855"/>
        <property type="gene ID" value="EA462_10670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="172" mass="20227" checksum="CAB64B3A5DD48217" modified="2019-02-13" version="1">MMKTHKPMEESEYKSFGNNHMYNPDTVIFRHAEKYYQVLSTGDQDQVTNCRQQLFHHLSAYQHCLNTDEPPRDSWTVLQLTIRYASTYAKNYVKSDDYSSPETVKVIRQQMVEEGRRLPYGVAEWIVQHVEARSTNQRGGMEEMQDGFTGFNDEKLQQRIKFDSETLDTAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1X8</accession>
    <name>A0A3N6P1X8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91559">
        <property type="protein sequence ID" value="RQG91559"/>
        <property type="gene ID" value="EA462_06265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="6503" checksum="31C83068FB128735" modified="2019-02-13" version="1">MALELDHECPDCGVERTFYRAASTTLHLGEKVKWHCPDCDYGFVRIGDNGTAVDSSVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P290</accession>
    <name>A0A3N6P290_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89265">
        <property type="protein sequence ID" value="RQG89265"/>
        <property type="gene ID" value="EA462_10620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="76" mass="8936" checksum="A9EEFFA406A5C90B" modified="2019-02-13" version="1">MRRFEVGDRVRIDIPDKGDPDFELYHDRKGEVVDLIEDDADAVTGDVRDSYLFAVEFGNGEIEHFRWRDLRPVPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P297</accession>
    <name>A0A3N6P297_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89275">
        <property type="protein sequence ID" value="RQG89275"/>
        <property type="gene ID" value="EA462_11435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="232" mass="24442" checksum="773015AE3296EAB0" modified="2019-02-13" version="1">MSSFETPHETGRGFGLSSREARVIGGASALMAINVALMYVFVSTPLAVVNDYLFAAPILGVLVYGAAIMVGELIAERGVTSGDMGVAFAGVALLQLAFGVFGAGVISFAPAEAHLTILGLTAAVTAVATAIISGYVYARSTTFEHWGRFANLAFIGGVVVIAIGTFVLPALLAVGFVFIFLGFLLRLGYEIWQVRDRRDASATLQTIGVYIAVAGVFVHILQLVMRYVLSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P473</accession>
    <name>A0A3N6P473_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="6">ATase</shortName>
            <ecNumber evidence="6">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="6">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 13" type="primary">purF</name>
        <name evidence="13" type="ORF">EA462_00235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6 10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92699">
        <property type="protein sequence ID" value="RQG92699"/>
        <property type="gene ID" value="EA462_00235"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="5"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6 8">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG92699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="490" mass="53404" checksum="74B0DBA24D89C971" modified="2019-02-13" version="1">MTEKCGVVGVSLDGRDAARPLYYALYALQHRGQESAGIITHDGFQQHSHVEMGLVGEVFDESDLDVLNGTAGIGHVRYPTAGSVDSSCAQPFSVSFKSGSLGLSHNGNLVNADEIRDELAGVGHAFTSDGDTEVIAHDLARNLLEEDLVRAVKHTMGRIHGSYALTISHDDTVLGVRDPQGNRPLCLGKLEDGYILASESAAIDTLDGDLVRDVRPGELIVLEKDGQGYDSYQLVENDNTAHCFFEHVYFARPDSVIDETLVYEARRNLGRRLWEESGVETDVVMPVPDSGRAFASGYADAASETTADGEMREEDDDGVEFAEGLMKNRYVGRTFIMPTQDERERAVRLKLNPIKSTVEGKTVTLIDDSIVRGTTSTQLVQLLKDCGAAEVHMRIGAPEIVAPCYMGIDMATREELIASDKTVDQIRTAIDAESLAYLSTDSVADVLGKDRIDLCLGCVTGNYPYEIDGEETDRDVTRPELGDQPMYADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4I1</accession>
    <name>A0A3N6P4I1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92859">
        <property type="protein sequence ID" value="RQG92859"/>
        <property type="gene ID" value="EA462_01145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="276" mass="28959" checksum="BEC7159FB55F3F35" modified="2019-02-13" version="1">MVVIRSLKRTPGLLRSEPIIFVPILVIGLLQAPQLFAQSLDPVVSTVVSLVMTGLFVFVMPFFFGGLIGMVNDVATSGRTSLGRFIGHGKTFYLSILGAYLIVFALTMTLGFALGIGVVVGVIGLFASGGSALAIAVVVLLLLVFLVIYLAIIAVFQFYGHAVVLDGARAVDSLKRSFDVVRTNLRQVVGYYLVLIVGGVVIGGIYGAMMLLLFPPATPGEPAPMPDLGPALVGVGGSALLTTLFGAVFLVYSVVFYRAITGLDEPTTESSEPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P997</accession>
    <name>A0A3N6P997_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Twin-arginine translocation signal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_00660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92775">
        <property type="protein sequence ID" value="RQG92775"/>
        <property type="gene ID" value="EA462_00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07477">
        <property type="entry name" value="Peptidases_S8_Subtilisin_subset"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034202">
        <property type="entry name" value="Subtilisin_Carlsberg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="148"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="454" mass="47045" checksum="06E23093AAB069F9" modified="2019-02-13" version="1">MTLSRRQLLQGVGAGVSAGLVGTVVSEPASASSSPSSDTRRVFVHPENGLLGDLLDAVEGVGGTTLLEFDNFEFVVAEVPSNRVSDLAGAAGIAFVEDDEETGIPDDWSPSLLDVLVPPDRSDCSTHPDQRTSWGLERIGADDVDPGGSDVDVGILDTGIQSDHCSLSVAGGRNFTATGTPSDYEDRHGHGTHVAGIAGAVDNDLGMVGTAPDTNLYAVKVLDDDGRGRYSELVAGIDWCLSNDIELISMSLGGENESETVDDVIETATSDGHLLLTAAGNEGNAEDGSCDEETMTYPATHDDVLAVAAMDEDDTLASYSSVGSAVDLLAPGTEITSTITDNEYAEASGTSIACPFVTGVAALVWGISEADGPGPNDAIRRTLTDSAEPVLETCEEGHGLVDARAAVDGDVPDADDSSSDREGEPTDRGESRSALEWLADAVSGLLERIRELFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9N1</accession>
    <name>A0A3N6P9N1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="10" type="ORF">EA462_01755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92965">
        <property type="protein sequence ID" value="RQG92965"/>
        <property type="gene ID" value="EA462_01755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="8">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="9">
        <location>
            <begin position="309"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG92965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="593" mass="65138" checksum="501B7931A8ECAE2E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LH83</accession>
    <name>A0A3N6LH83_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS1595 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_17365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000011">
        <property type="protein sequence ID" value="RQG86090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86090">
        <property type="protein sequence ID" value="RQG86090"/>
        <property type="gene ID" value="EA462_17365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018658">
        <property type="entry name" value="DUF2089"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024442">
        <property type="entry name" value="Transposase_Zn_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12762">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09862">
        <property type="entry name" value="DUF2089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12760">
        <property type="entry name" value="Zn_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="2">
        <location>
            <begin position="120"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="294" mass="33753" checksum="2C408B91262B08B5" modified="2019-02-13" version="1">MFPVNRFVSESAAADLLQQVRWRNGVECPRCRSDLTVRNGSYRVYQRYLCKNCGRTFNDKTDTIFAHSKLTLKEWYFTIYVFLRFNTSIRQIEAELDLSYRTVRQRVERFARALDAPSLTLSGPVEIDEVYVSAGLKGRERDQKSRSRGLSTRGRGSYEGDKPPVFTLVDRGNDQRYVVPAKSADESTVRLLLADHEEEPLTVYTDGFRAYDPLEKDDAFAREYVVHGDGEYADGDVHVNTCESHGSLVRPWLSPHRGVSKDKLTPYLRAFQLRRELYRKPGDEALKHAIDAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHJ3</accession>
    <name>A0A3N6LHJ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_17065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86180">
        <property type="protein sequence ID" value="RQG86180"/>
        <property type="gene ID" value="EA462_17065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043867">
        <property type="entry name" value="DUF5827"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19145">
        <property type="entry name" value="DUF5827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="88" mass="10107" checksum="10DFA95DB1D9BC75" modified="2019-02-13" version="1">MPVPKSEFDSLSPCDFYTPDELFEQEQMYTVYEIARLLQGLDPDAEIDRETEDVLLDWAIPWIMTNADDLVVAEPRSGDEPGYYGLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI42</accession>
    <name>A0A3N6LI42_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86759">
        <property type="protein sequence ID" value="RQG86759"/>
        <property type="gene ID" value="EA462_16630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="238" mass="26391" checksum="DD3AFF878A2CF1F8" modified="2019-02-13" version="1">MSASVRRRHSVRFLSLIYFDSFVVPRVVGAADAFFTYWCDGSGRMAEPGNTKRGAQLTRRRALAVAGTVSLGTTAGCLDSIQSIGGSRTEIEPTEPDDGTDSEDDGNHVPTYGEFYYHLEDAGITVDELYHDTDDDDLILFYESDAETRDESDDEIAQIYVLFRDELVARGSDVSHMYTEVTDGFDEQVDGWGVNSEWAEDDLAGDAGPIDVWNAIVDTMVYEGDSDRYDLPEDSTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIP5</accession>
    <name>A0A3N6LIP5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_13110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87806">
        <property type="protein sequence ID" value="RQG87806"/>
        <property type="gene ID" value="EA462_13110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="4"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG87806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="347" mass="38193" checksum="DB43D18E57A936EA" modified="2019-02-13" version="1">MSLVNIDGVSVEYRTDNGPLTAVDDVSFTIEEGETLGIVGESGCGKTTMTKAFLRLLDNNGEISTGSITYDGIDLATVSEEQLRTDIRWKEISYIPQNAMAALDPVYTVGAQVVQVIELHTDNSTEQARERCAELFKRVDLDPNRMGDYPHELSGGQRQRVTIALSLALSPSLIVADEPTTGLDVIVQDQICELLAEIQDDIGCAIVFVTHDMGVVSNISDRVAVMYAGRIAEIGTIDDVFDRSAHPYTIGLQNAFPRMDEFPASSALIEIPGSPPNLLDPPTGCRFEGRCPYATEECRHTDPSSVELEDGHRIECLYPERRSEFREHGNEPDTWKDAREAEAKQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ21</accession>
    <name>A0A3N6LJ21_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_14390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88036">
        <property type="protein sequence ID" value="RQG88036"/>
        <property type="gene ID" value="EA462_14390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG88036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="42325" checksum="4EBD7B4A47381695" modified="2019-02-13" version="1">MTSLETKQEVPETDVEPTIKIDNLRKEFDVPGGIEVAVDGVSLDIGDGEFVTLVGPSGCGKTTTLRCIAGLETPTSGQITHEGEDLTYIPANKRNMAMMFQNIALYPHMTIVDNIAYPLKVIGVPKSERHEEAREAAEIMQIGELLDKYPGELSGGQRQRAALARTLVQDPVAFLMDEPLSDLDAKLKVEIRKEIQKVHKRLEKSTVYVTHDQEEAMTMSDRIAVMNDGQIEQVGTRDELYNYPVNTFVASFIGNPSINYFDGNVLDLSEERGAIDVHGTTIEFDVEYFSDSLSGSDVRVGFRPIAVSLEMNSSGGQFEGSLELLEPVDDRALATVDGPEGELRAHIPTNLPLEEEETVQIEIDTTDLYIFDGETEELVARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ44</accession>
    <name>A0A3N6LJ44_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APC family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_13490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87871">
        <property type="protein sequence ID" value="RQG87871"/>
        <property type="gene ID" value="EA462_13490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="451" mass="48468" checksum="EAC5E5C0077424EB" modified="2019-02-13" version="1">MSKADTEKLATIGLLGAVAWIIGLNLSSSLWVIPAVAVNITGTSAVTSMLIVVIPVLLILPAYFVLVRSEPTNLGHFKYPARYLSDNTHLNQFLTTAGTFSFFATVSMFALPLAAITAGDFLNTVHSPIPPITYAVAVLALAYVTNALGVRIVGMVEIFFITLLFVAVLLLTVGGVQHMEPANFAEFFAGDTATYIATWPLVFTLAGGALFAIDLGSDIRDGSRNVPIVLVLGILGVMILSAMITLVVAGTIPHDELAGETVAYVASQILSGPAFVFTAIFGALFASFSTLVAAMTLTGRYLAEPSQFNVYPKSLATENRFGEPMYALTISFVIAIVFLFLGLPFQMLIAGFTFSFLFLYSLVTISGIRYVKRYSDQVERNGANRSFFTSPKAVTWGGFIALPIYAVFFVFLALENPVAFGAWFATLLIGGVYYLVRSRMTGEMPAAVDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ76</accession>
    <name>A0A3N6LJ76_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87931">
        <property type="protein sequence ID" value="RQG87931"/>
        <property type="gene ID" value="EA462_13800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="110"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="359" mass="38731" checksum="69A346DDABC8B180" modified="2019-02-13" version="1">MPRKSSRRNVLTAVGAGLTVGIAGCAGDDNGNGNGNGTGNGNGNGTGNGNGNGNGDDDVLPDTLRIGHPGPTRPTYAAPPYSHFLDEMEARGVTVEPVTFDGFGPMIAGMISEDVEIGYVTPPSLANAIAEGFPVSSFMELSQAFSQQVCTAPGIDSWDEIEGETFILHSPSSFSAMVGRSAVEANLGDPEAVEYQYIAGTPNRIAAIEAGEGVATTAFLAGVLDAEEEGIVQHFSNPNDDFDHMTLATWATLDENLDQNEAMHQEIVDVMLESYEDMYDRDIAELVEYIQTAPTDFPDYGEEVWSETLETAREDEMWNTDLSEHITDEKFQTSLELADRADLLEEMPDVDDLVDRRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJF7</accession>
    <name>A0A3N6LJF7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88813">
        <property type="protein sequence ID" value="RQG88813"/>
        <property type="gene ID" value="EA462_10435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="113" mass="12403" checksum="879F25838036D743" modified="2019-02-13" version="1">MTDQPPSPSSPAWPSAPRPRQTESPDSRSDGRAIVTTAQLAASLENAVGYRIEEGRLDELLLELERQNYVEWAGISRTGDYVWDLTDAPDRIAAAVATAVGSRFRAWLESRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKS0</accession>
    <name>A0A3N6LKS0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_11565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89278">
        <property type="protein sequence ID" value="RQG89278"/>
        <property type="gene ID" value="EA462_11565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="54"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="4">
        <location>
            <begin position="303"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="376" mass="42370" checksum="09DA9E95B7218DCE" modified="2019-02-13" version="1">MGDDPDGGMLSWDESVFRNEHVFEIDYVPETFKHRESQTESLTYALRPAVRGSRPLNVMVRGPPGTGKTTSIQKLFDEVGTQTSEVRTIRVNCQVNATRYSVFSRLFEGTFDYEPPSSGISFKKLFGQIAEKLVEDDRVLVVALDDVNYLFYENEASDTLYSLLRAHEEHPGAKIGVIVVSSDPALNVIDELDSRVQSVFRPEDVYFPVYDQPEIVDILDERVRRGFHDGVISRATLEYVAELTAESGDLRVGIDLLRRAGLNAEMRASRTVEREDVEGAYEKSKYLSLSRSLSGLADTERALLEVIAHHDGDQAGDVYEAFRDRTDLGYTRYSEIVNKLDQLGLIDAEYADVDGRGRSRSLSLSYDRDAILDRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKT3</accession>
    <name>A0A3N6LKT3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-quinone oxidoreductase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_15840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87098">
        <property type="protein sequence ID" value="RQG87098"/>
        <property type="gene ID" value="EA462_15840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="98"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="6"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="235" mass="26307" checksum="00A563410CCE5F83" modified="2019-02-13" version="1">MSSDEPRQTIHDSTAPSTDTRDARIGDGLDDRFNSKLREAFGTSPFILTKFDEFMNWVRGNSMFMLQFGIACCSIEMIHTYAIKHDVDRYGAGVPRASPRQADVMIVPGTIVSKFGPRMKRVYDQMPEPKFVVGMGSCTISGGPFQEGYNVVKGAEEIIPIDIHVPGCPPRPEALIYGILKLQERIKNGESSPVVVKPYELEEFGDLPEDELVRKLASEIDEDDLVMRYNWADSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKU6</accession>
    <name>A0A3N6LKU6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87118">
        <property type="protein sequence ID" value="RQG87118"/>
        <property type="gene ID" value="EA462_15955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="271" mass="30808" checksum="A2AB1D52E299DD05" modified="2019-02-13" version="1">MERANAELFESQLTKGRDEVLLLSPVFLQVMDLDKDRVQEFVDDSVSYYEEQSIIGNGVSFHLRGSERITFSECRKETTIGVDTLNSETGVIAIRNQIDQIIDCEETAVIQDLDNEASLEEAISSSEFARDLFTESIHGVPLSSDNRLLLPDHQNYRDILIDEYGMDEYLPHGDQVPIYWFAPDIFQDRGFVVRNNVPVVQEVHGSKYGIVNERLDIGELKEDNSENRLMIHLGSTGYHPIEVSLWTKFSSLQTFDDESVCQLELPDPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLE3</accession>
    <name>A0A3N6LLE3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87920">
        <property type="protein sequence ID" value="RQG87920"/>
        <property type="gene ID" value="EA462_13740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="145" mass="15639" checksum="7C39E13F566CB5D0" modified="2019-02-13" version="1">MAIVAAVDREERSRHVIREAERLADSFGDSIHVVHVLTRSEFVEMGVDSAESGTDGVSMDDIRDAATRIAAEAGDDIESEWEAVGLIGDPATRVIEYADEQDARYVVVAPRKRSPTGKVLFGSVAQTVLLNADRPVVTVLEGDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLM9</accession>
    <name>A0A3N6LLM9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89913">
        <property type="protein sequence ID" value="RQG89913"/>
        <property type="gene ID" value="EA462_07840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017271">
        <property type="entry name" value="Tscrpt_reg_HTH_MJ1545_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037724">
        <property type="entry name" value="TF_HTH_MJ1545_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="236" mass="25918" checksum="5BCB71A2EDDFB30F" modified="2019-02-13" version="1">MGGRGPKRELAEKIAGEITLSNDPGATLRKWRTDFDISQTDLASELDVSSSVISDYESGRRESPGIGVVGRLVFGLLEIDERRGGDRIRQYGRVLSAGFDSDVVLDLREYATSIPVSRLYDELEATQIAPGSTDRISGHTVVDSIEAITRLSSEEFFRLYGQSTNRVLVFTNVTRGEGVGIALRVVNPTPNAVILHGIEEDELWDHARDLARIDGYSLGVTTAPLEDVLERLVTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM48</accession>
    <name>A0A3N6LM48_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1102 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88827">
        <property type="protein sequence ID" value="RQG88827"/>
        <property type="gene ID" value="EA462_10520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="203" mass="22160" checksum="A2872D79E3FC5478" modified="2019-02-13" version="1">MHRRTLLLVAGGSATSTGIVVGSGALSREVAGVRVEVSEDPDGYLGLEPCPRSPNRRYARLDGNGHLKIDLSPSNSIRKSKTKQTGLGINGNAVTYIHDVFRICNQGTEPVTAWIEVPERIPVQTKKDKGSVKPADEDRVAFYKGSQVDRRVDSESNALTLSIGECTCIGLSISTKLLSKEDSYLDVERIIVHARQIEETTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM53</accession>
    <name>A0A3N6LM53_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L18Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein L20e</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein LX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl18a</name>
        <name evidence="3" type="synonym">rpl20e</name>
        <name evidence="3" type="synonym">rplX</name>
        <name evidence="5" type="ORF">EA462_09190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Binds 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90153">
        <property type="protein sequence ID" value="RQG90153"/>
        <property type="gene ID" value="EA462_09190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_L18Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="50S_L18Ae/Ribosomal_L18a/L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_L18a//L18Ae/LX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18A" evidence="4">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="58" mass="6561" checksum="0C43A9F088BCAB93" modified="2019-02-13" version="1">MSQFTVTGRFKSRDGLAEFETTIDAENENVAREHVLSQLGSQHGLNRTQIDLEEVAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LME6</accession>
    <name>A0A3N6LME6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90263">
        <property type="protein sequence ID" value="RQG90263"/>
        <property type="gene ID" value="EA462_09800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="109" mass="11094" checksum="D25D62B79CBA2FBB" modified="2019-02-13" version="1">MTANLTPRASTTNSTDTGSDPLTDSGATPSTDPSSSACTTDVLEPFPYRIDETASELPSPSANGVLRSDRACDTTGVAGRLSCPACGEATVNGAGLFTCVECSWDGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMH4</accession>
    <name>A0A3N6LMH4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90303">
        <property type="protein sequence ID" value="RQG90303"/>
        <property type="gene ID" value="EA462_10015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="714" mass="79426" checksum="A33B40AACD58FE6F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LML4</accession>
    <name>A0A3N6LML4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86785">
        <property type="protein sequence ID" value="RQG86785"/>
        <property type="gene ID" value="EA462_16760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="244" mass="27400" checksum="CBBDA84D97CDF725" modified="2019-02-13" version="1">MERRITNWNMCSSTSLPRIDDCLELYLIVTDRHGTSTFTRDDINQYRHIEDVESLLELGVAYGLFAVDSSQYRIRCEPDASRADWQEATTERATTIQRTISNRLESMRGSGAVNGSVAATGSKTTVDSDTTTDSVRTELQRDDGREVLQHESDRYTSVFVSESDGFDAVFEALVSVPVDDCAGVVLRAPGEYASHVQRFADRLCTNSIVDESSLSTSYRKEYSDVVGDDKNELEFRLFLRELST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LN52</accession>
    <name>A0A3N6LN52_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87005">
        <property type="protein sequence ID" value="RQG87005"/>
        <property type="gene ID" value="EA462_15280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="94" mass="11236" checksum="6C3A50A8D5A48751" modified="2019-02-13" version="1">MTTDQNETGETEPDEDDRDVNRKDEHGRDIELAREDTDAEEDESELTEAEKEARERRDEKQRRQDIDHKSTQRENDALENENPDHHRDEEPYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNX5</accession>
    <name>A0A3N6LNX5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87907">
        <property type="protein sequence ID" value="RQG87907"/>
        <property type="gene ID" value="EA462_13675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="147" mass="15791" checksum="47FF70BAA6677D3E" modified="2019-02-13" version="1">MGTIDSIYVGSGTQLTRMFHVVAGIDDNTERALEQAKAIASLPSAPEEVSVTLVHTFTFKEPETTIDDIEAVDAVRTHLDEQGIEHDTHEGDGEPSEYLVQYATEQDADLICVGGRKRTPAGKALFGSVSQQVLLGADRPVLVSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP46</accession>
    <name>A0A3N6LP46_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88017">
        <property type="protein sequence ID" value="RQG88017"/>
        <property type="gene ID" value="EA462_14270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="91" mass="9748" checksum="8E92989DD721B558" modified="2019-02-13" version="1">MADGYASVGHPQDEEVTPSTIAKLLLFLVWWFSGIGVGTAFMSPGVIGTTISTELFMAILLSHFCSVLLITVLLPGPEDSTIDQGVDRMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP71</accession>
    <name>A0A3N6LP71_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88057">
        <property type="protein sequence ID" value="RQG88057"/>
        <property type="gene ID" value="EA462_14500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="424" mass="47283" checksum="0B34A622020BEAFF" modified="2019-02-13" version="1">MTDRPDPNEGSDSHDDEAAKPLEGIRVLDFSWVYAGPHATKHLAALGADVVKVESKYKPDMMRYGYTYDEFDSADSPNVSAFYNEFNLGKRSLRLNLKRERGRELALELAAAADVWVENFSPGFLRSIDLDYESVSAVNPEIVYVSMPGWASSGPAADYRAWGMNLESMAGLDHLSGTPDDPPTPAGFSWPDPTSGVMAVFSVLAALAGRESTGKGRYVEIPQFETTVSLLHSALSVADITGESGERMGARDEDRRFVQGVYECRGEDDWLAVAVGTDDQWRALCSVIERPELATDPELESHAARIRHHDRFDAVLESWTRKRDAETARTILQEHGVPAGRVANERDLVEDDPQLHQRTLFVRHDHPEVGEQTYTGFPSEFSEDDVNPPSRSPLFGEHTDDVLRDWLGTSPERIDRLRADEVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP72</accession>
    <name>A0A3N6LP72_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucS</name>
        <name evidence="3" type="ORF">EA462_07755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89897">
        <property type="protein sequence ID" value="RQG89897"/>
        <property type="gene ID" value="EA462_07755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="251" mass="27263" checksum="9998D1D89BA61121" modified="2019-02-13" version="1">MTTTENAAIHTIEQPSIAAGHDLIESGLERDALVTVFGRCTVDYDGRASSQLDAGDRHVMLKPDGTTLVHTDEGQQPVNWQPPGCEHAVRRVAADDGTEELVLETNRSTPAERLLVRFSTVRQISAFSGTDESDLTLSGTEEDLRTRILDEPELLGTGFTPLATERETPAGAIDIYGEDSSGRAVVVELKRRRVGPDAVSQLRRYVDSLGRDLHADASIRGILVAPSVTDRADRLLAEHGLEFVSLEPIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP92</accession>
    <name>A0A3N6LP92_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91253">
        <property type="protein sequence ID" value="RQG91253"/>
        <property type="gene ID" value="EA462_04485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="450" mass="49762" checksum="C6B1D876102099D6" modified="2019-02-13" version="1">MSSFIVDRITADGTSLECDVRPSADLERFVTGDPFRIDYDRSIEDVPEGILAIPVLANVCPVAWANGADVYVDEVDAAFARALEDVKASLLSMYDFLEGGTLYARRTIDPEMSSQPGASAGEAAGGSTSDPKSALLFTGGVDSTCSYVRHREERPTLVSVRGWTITPDPSDDEKWNDLRARVSSFADERDLETAFIESNVLSALDHPMLLAHYKRHVDGAWYSSVGHGLGLLGLCAPMAYVRGVDDLLVAATHWDGIDLEWGSRPDIDDHVRWTGTRCHHDAYDLTRQERLDLIADYVGTSTPELELQTCNVRMDGNCGECEKCYRTAVGLRLAGLEPTAHGYPFADGDYDEIRAALDSGEWVLGQDERHMWGDIRDRVRETEPSSENEAAFFEWLVEADLDELVADSRPPLSHRLFRAGARNAPTRVYNGVYPALKAAKIGADRVRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP95</accession>
    <name>A0A3N6LP95_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF362 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91248">
        <property type="protein sequence ID" value="RQG91248"/>
        <property type="gene ID" value="EA462_04455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="1">
        <location>
            <begin position="61"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="316" mass="33540" checksum="F3F0FD15097E4D4D" modified="2019-02-13" version="1">MTDDRVRVAAGTGLDHGGWRPDVDARMAVLEPPIRRLLDANTEALTEADRITLVPDVHYPFHPSTGMVTDPAVVGAIASYLRSRGDADLVVAGASGERIEFDRTLAYLGYPELLERFDAEPVDLVRDEPRTNEIVCVDGRSVPFSVPATLGESTVIVVPTLRPTEEGPVAGGMRTLAAADERTVDPDVTAVAATRVVDPVLSVLDATTAYGSDPHAANAIFAGSTPSVDAVGASLLEREIEDDRALELAFEDGPETITLERVGAGADRVDVEDIRERLGGGELPPTGTMHPAVTAAYRLYATVGRDAVPPQIEGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPD2</accession>
    <name>A0A3N6LPD2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89987">
        <property type="protein sequence ID" value="RQG89987"/>
        <property type="gene ID" value="EA462_08245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="107" mass="12478" checksum="6C8A63252DB6A747" modified="2019-02-13" version="1">MSLEDLNDEVQESYTEFDDELAVSLDRETRNELALLETALEPAETDELVRRAIHMLFQTTVDTGTLDFHLRSGFDVTYDEYLTGMTFDEMTGADQYPSMDDERRYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPE8</accession>
    <name>A0A3N6LPE8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91328">
        <property type="protein sequence ID" value="RQG91328"/>
        <property type="gene ID" value="EA462_04925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="118" mass="12902" checksum="46185A688EAD112F" modified="2019-02-13" version="1">MKLRQPTDFLILEALEDKGRNVATNLAAHTGKSRKNINTRLPVLEDYGLVDKIGPAERSGLYEISTQGKAALIYQDQYDEADDFEALIEGPSAADAPSSADAQASFVRGEENDETEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPL3</accession>
    <name>A0A3N6LPL3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalamin B12-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_08860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylamine corrinoid protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90097">
        <property type="protein sequence ID" value="RQG90097"/>
        <property type="gene ID" value="EA462_08860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="138" mass="14825" checksum="F69A824496D7D0D4" modified="2019-02-13" version="1">MVSTQEGRSIRCLVSKVGLDGHDRGAHVIARAFRDAGFEVIYSGLHKAPEEIVQAAVQEDVDVLGISILSGAHDTLVPKIMDGLAEYDAKDDTLVLVGGVIPDEDRQELRDAGVAAIFGPGTSIEETIEFVRENAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPR0</accession>
    <name>A0A3N6LPR0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90167">
        <property type="protein sequence ID" value="RQG90167"/>
        <property type="gene ID" value="EA462_09265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="206" mass="21560" checksum="AF2195E915D58597" modified="2019-02-13" version="1">MSNETTASDGERKASVIVVGGGPAGLSAALFTAKNGLETTVFDTDETWMHKAHLFNYLGVGSVGGSEFMATARQQVDDFGVDRRQGEPVTTIEIVDGGFAVETADGIDESDYVVLATGADRKLAEDLGCEFTSTDVVDVGVNMETSVDGVYATGAMIRPEEWQAAIAVGDGAAAALNILSTVRGARFHDFDVPDDAGRVFGEVLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ73</accession>
    <name>A0A3N6LQ73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91728">
        <property type="protein sequence ID" value="RQG91728"/>
        <property type="gene ID" value="EA462_06470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="116" mass="13183" checksum="C9CBD64B2FC554DD" modified="2019-02-13" version="1">MSVTAAEAELSDDEWNGLELVRETGGIHQSDFWKELDVSSRKGSRIVESLVEKDLVDREDTVYDGHNTYYITPTARDLEFTLLMAGDMLSPFIGEEEVDPNSDAFSQWIMNLAYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQB0</accession>
    <name>A0A3N6LQB0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-binding protein EA462_12240</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_12240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89134">
        <property type="protein sequence ID" value="RQG89134"/>
        <property type="gene ID" value="EA462_12240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00026">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022889">
        <property type="entry name" value="DNA_bind_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PTHR10840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="SSF46950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="116" mass="13306" checksum="0431783AF76B0B64" modified="2019-02-13" version="1">MSDAPDEEKLEQLRQQKMEQLQEQAESGQGEGSKEAAQQQADAQKQALLRQHLTDDARKRLNTVKMSKPQFGQQVEQQVIALARSGRMQGKIDDDKMKQLLKELKPDSKSFDIKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRJ7</accession>
    <name>A0A3N6LRJ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89764">
        <property type="protein sequence ID" value="RQG89764"/>
        <property type="gene ID" value="EA462_07020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="147" mass="15573" checksum="86B0B48519F59C68" modified="2019-02-13" version="1">MYDDVLVPTDGSDTITETLAHAIPIAADNDATVHALYVVDSRITAAAGEENSSAIERSLEADGREAIDTVEERATDAGLETASEIRKGTPSKILLDYADERGIDLIVIGTKGKSPREKVTSLGSVSERVVDNASVPVFVVRDVDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRQ4</accession>
    <name>A0A3N6LRQ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91117">
        <property type="protein sequence ID" value="RQG91117"/>
        <property type="gene ID" value="EA462_03730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="59"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="186" mass="19479" checksum="D4468035A8EE23CE" modified="2019-02-13" version="1">MATRLEVFENAIRETNASVTVATPETIDEILSKVITLPAVGAPLPFDDVSLERVSPSIDTRPTRIQLLEAETGVTGATLGIASYGSVVLRATGDVDELAALFPERHVVLVRECDVVDDMVTAFDELAPIVESDGADVIVATGPSATADMGALVHGVHGPTEVHVVIVATDDGGIEEDATDDPEGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRS0</accession>
    <name>A0A3N6LRS0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91137">
        <property type="protein sequence ID" value="RQG91137"/>
        <property type="gene ID" value="EA462_03835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="83" mass="8676" checksum="0A4FC89A4B892E22" modified="2019-02-13" version="1">MLPTPNTDPQAHTNARRLASTMSESVVTPVRASAFWATIILPLLALVLLGTGIVSISLVTVASFVAVYGTCAIAGHNHTPNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS29</accession>
    <name>A0A3N6LS29_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90034">
        <property type="protein sequence ID" value="RQG90034"/>
        <property type="gene ID" value="EA462_08495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="321" mass="33969" checksum="D85B03F3D7F09E85" modified="2019-02-13" version="1">MRAVHLHEQGDPDVLQVENIDRPEPADDEILVEVAAAGVNPVDTYFRDGSYEPAEVPFTPGVDLAGVVAETGESVTEFDDGDRVYGTGIGNGTFQGAYAEYATVPVDRVVSLPDGVDLVDAGAAGVAAVTAWRALIDHGDLEPAEYCLVHGGSGGVGHAAVQIGAAVSARVITTAAPEYHDELRNLGATAVLDYVRDDLEDAVLEASDGGVDVILDHRLDDYLQFDADVAAKNARVVGIGENSPDPAFSNDGTARSKDVTYTFMSMFNAPDLRVPLRGTAHLMDAGELSIELARRYDLDEAGEAQRAVMEDSVFGKLVIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS84</accession>
    <name>A0A3N6LS84_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="8">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="8">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">gatB</name>
        <name evidence="10" type="ORF">EA462_08960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90114">
        <property type="protein sequence ID" value="RQG90114"/>
        <property type="gene ID" value="EA462_08960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="9">
        <location>
            <begin position="348"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG90114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="496" mass="54870" checksum="779FA5AB73E4191B" modified="2019-02-13" version="1">MTAQTVQQGDLVTVIGLEVHVQLETDTKIFCGCSTDQQNGPNENVCPVCLGLPGALPVVNEGAVEAAVKIGKAIDADIPEETRFHRKNYYYPDLPKNFQITQYDEPICADGELEVSVESTRRTIAIERAHLEEDPGSLQHVGGGIDTAEYTLVDYNRAGTPLMEIVTAPDFRSPDEVRAFLAELEEVLEYLGVFDAERDGSLRIDANLSIIPSEEIDGDGEDDIGADALETANRTEVKNISSHKGAQKALAYEETRQKNAIQRGRAVEQETRHWDESRGITVSMRSKEEEKDYRYFEEADLPPLRVSHWKDEIAIPELPTARRERFQAEYELTEEAASKLTSTKQVADFYEDVAGEYDPDLAATWVADNLLGELNYRDMEITDIEGRLEEVTRLVELVATDEITAKNARETVLRAMLDGGRTPDEVVAEADLGKTDEGEVKRAVVDAVEENPDAVSDYESGDDGAINFLVGQVMQKTGGSADPGDVNQLLRAELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSC2</accession>
    <name>A0A3N6LSC2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90164">
        <property type="protein sequence ID" value="RQG90164"/>
        <property type="gene ID" value="EA462_09250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="172" mass="18775" checksum="AB700EB07C81F33A" modified="2019-02-13" version="1">MTPSETDRRTILRHVGATLAGSLSASAGCLDRNTEPRTDDADEPIVEEAEATALEGDADPDAWTDVESIRLDGYVGGWVGVEPPHIDRIENPTLVLFDGSEYEITWMNRDGVKHNLALHDVEETVVGEYATGVTEEIGATTTLEFVARSEMVRYICEHQPAIQYGSIDVVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSY1</accession>
    <name>A0A3N6LSY1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93093">
        <property type="protein sequence ID" value="RQG93093"/>
        <property type="gene ID" value="EA462_02500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="75" mass="8583" checksum="13E5B4D231625EC7" modified="2019-02-13" version="1">MPQFTEGDRVRVDIPDELDPDHDRYHGRHGKVVEIMEDDAGDETGNDQDSFLLQVEFDSGETMGFRGHDLRPPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUA4</accession>
    <name>A0A3N6LUA4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="6">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadC</name>
        <name evidence="9" type="ORF">EA462_03820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91134">
        <property type="protein sequence ID" value="RQG91134"/>
        <property type="gene ID" value="EA462_03820"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="8">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="7">
        <location>
            <begin position="102"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="273" mass="28766" checksum="DA64AE2FCCDB09B6" modified="2019-02-13" version="1">MTLVTDTDVERWLREDLGHHDVTNQVPGETTGRLVAKESGILAGLEAATAVFDYLDVTVRDHVRVGSHVDAGDEILSVEGSARDVLRGERLVVNLVGHASGIATATHAAVDAARTESTDVRIAATRKTTPGLRGLEKRAVVAGGGDTHRLDLSHMVMVKDNHVSEMGLEGAISHFRERVSFATKIEVEVEAVDDAPRAAEFGADIVLLDNMTPEETAAAADALSEYETVLAEASGGIALEDVAEYAATGVDVISMGSLTHSASSLDLSFRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUG6</accession>
    <name>A0A3N6LUG6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91204">
        <property type="protein sequence ID" value="RQG91204"/>
        <property type="gene ID" value="EA462_04230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="355" mass="39050" checksum="1C4938246170502C" modified="2019-02-13" version="1">MTSPKAREEAVLEAVRKRRDRVNAAIPEDLPIQPPTRLYEASRYLLDAGGKRLRPTVLLTTAEALADVQPLSVDYRGFPTLSGAEPGSVSKIDMMNAAVSVEVIQSFTLIHDDIMDDDDLRRGVPAVHKEYDLETAILAGDTLYSKAFEIMLDTGAKPDRTVDALEVLATTCTKICEGQSHDVSFEERDDVSTEDYLEMVEQKTAVLYAASACLPAILMEADAETIDALYGYGLDIGRAFQIQDDVLDLTVPSEELGKQRGSDLVENKQTLITVHARDQGVDVDSLIDTNDVDAVTEAEIDDAVATLEETGSISYANEMARELVEDGKARLEILPDNEARELLFELADYLIERGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUQ8</accession>
    <name>A0A3N6LUQ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91314">
        <property type="protein sequence ID" value="RQG91314"/>
        <property type="gene ID" value="EA462_04845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="71" mass="7110" checksum="53F3E4303D26EF5F" modified="2019-02-13" version="1">MNGRTVAGALGSIGVLVVVLAGIYGFAGGSVLESPDELLAPTVGTLAVATAVVAGLIALGTRSVRRRTPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVB1</accession>
    <name>A0A3N6LVB1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91614">
        <property type="protein sequence ID" value="RQG91614"/>
        <property type="gene ID" value="EA462_06595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="117" mass="12219" checksum="2AA36A37D1BB31BC" modified="2019-02-13" version="1">MIDSLIVFGVSLLIGALGIYVGAKVIVDAEDYTYAIITALIGAIVWGLVGFFFGWVPLLGPLLVFVAYLAVVNARYPGGWVDAAAITIVAWLSVLVVLYVLAFLGVTGFDAVGVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVT8</accession>
    <name>A0A3N6LVT8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribbon-helix-helix protein, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92897">
        <property type="protein sequence ID" value="RQG92897"/>
        <property type="gene ID" value="EA462_01360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="58" mass="6716" checksum="9C46151C77931191" modified="2019-02-13" version="1">MPKISVEIPQELLEDLDEHVGDDGKFVNRSDAIRSSIRKNLDILDEIDARHDRLETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXF9</accession>
    <name>A0A3N6LXF9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86731">
        <property type="protein sequence ID" value="RQG86731"/>
        <property type="gene ID" value="EA462_16480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="28"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="315" mass="35413" checksum="83C5A06FA7D0573E" modified="2019-02-13" version="1">MTVHDFPDEQPGPVLAKLRKPRSQQLTRLAFVADIHLSTDGFGTSKVYHRTEELFETLISDINARDVSGVVFLGDQTHDGRPKEFDLFDTMVEQLQFPWISLPGNHDVPKEHDEHRSLLYTEFKRRYTPRGDGYPFVTEFNETSVISLNSSCTPDGCLRNTASGKISQQQLDYISGLDLDVSRTIVTLHHNLSLLPEHTVDYPWNQFQIENRTSLVDSLPANSSPLVVSGHHHLPAVTNTENYLELIAPAVCSFPQSYLLAEISSRGTTVFLVPLSDRDEITESYWFAKNGSVTSQGSLEMASNRLGRLPLLVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXG3</accession>
    <name>A0A3N6LXG3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_16535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86741">
        <property type="protein sequence ID" value="RQG86741"/>
        <property type="gene ID" value="EA462_16535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="69"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="256" mass="27930" checksum="29764B4717D59185" modified="2019-02-13" version="1">MSENANHPVTTSQKTIRILETIFQENGGTLTELASELGMNKSTTHNHLTTLVDEELVVRDGAEYRLGLRLLEFGGYARNQHALYQRALPEIERLAEQTGEIANLVIEEHGHAVYLACETGEQAVNIDVYPGLRRPLQVTASGKAILASLSPDRVDEIVDRHGLPAKTPNSITTQDELEASLAAVRDRGIAFDDEEHIKGLRCVGAPIHDSNGEVLGAVSVSGPASRMTDGRFYDEFPSIVNSTLNVIELNINQKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXJ6</accession>
    <name>A0A3N6LXJ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86791">
        <property type="protein sequence ID" value="RQG86791"/>
        <property type="gene ID" value="EA462_16800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="12"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="396" mass="41926" checksum="5081521838BF7774" modified="2019-02-13" version="1">MTDRGPLEWNGSVLLVLAAFVLAALNLRPAIASVPPVLELIRADLGLSYTAVSLLTTIPMFCMGLFAFLTPRVARFGRERGLFWAIVLVGLATAARVASHHLVVLFATTIIVGIAIAVGQTLLPALVGEYFPERPSFATGIYSISLAVGAILAAALTVPIYQTTSSWAIGLASWASLGIVAAVVLVPLVREREKSPVETETVRRRLPWRNPLAWTVTLFFAGTSTIFYSGLTWLAPRYVALGWTETGAGFLLTVFLLAQPIGMGLFTLFGDRFDDRRLWIVGMGAIAAIGTIGIAITPLSSPWFFVILFGTGSGGLFAIALTLPIDLAPDGQATDRLATMAMGIGYILSAFGPSLIGSARDLTGSYVPAFVAMCVVSLILGLIGTAFNPAYEGTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY07</accession>
    <name>A0A3N6LY07_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">HlyC/CorC family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">EA462_00315</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92714">
        <property type="protein sequence ID" value="RQG92714"/>
        <property type="gene ID" value="EA462_00315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="13">
        <location>
            <begin position="25"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="233"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="301"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="7">
        <location>
            <begin position="375"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="11">
        <location>
            <begin position="375"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RQG92714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="463" mass="51212" checksum="A7F5EC5CE9F88382" modified="2019-02-13" version="1">MVFSLPLEMVVAAYDVPVVGLEIAESTVTLFGGLAVVVLIALSGFFSSSEIAMFNLPKHRLEGMVEDGTEGAALVKRLKDDPHRLLVTILVGNNIVNIAMSSIATAVLSIHFGGLLGVILATFGITAIVLLFGESVPKSYAVENTESWAIRISKPLKATEYFLFPLIVLFDYLTRQVNRLTGSTGAIESPYVTRDEIQEMIESGEREGVLEEEEHEMLTRIFRFNNTIVKEVMTPRLDMTAVPKDAAIDEAIETCIQSGHARIPVYEGSLDNVQGVVHIRDLVRDLNYGETEAEDLELTDLVQPTLHVPESKNIDELLTEMRENRMHMAIVIDEFGTTEGLVTVEDMIEEIVGEILKSGEEEPVEELDDRTVLVRGEVNIEDVNEALEIDLPEGEEFETIAGFIFNRAGRLVEEGEEITFDGVRITVETVENTRIMKARLHKLEAPEEPEEGDGENGNGVSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYD8</accession>
    <name>A0A3N6LYD8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87141">
        <property type="protein sequence ID" value="RQG87141"/>
        <property type="gene ID" value="EA462_15610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="178" mass="20378" checksum="63059F054AEFBF20" modified="2019-02-13" version="1">MGLDELESFLRKKGAAELITEIGTGTATFNALVDAVAVSGSTVSSRLSEGVERDVFTVSHRPTEHGTEKRYELTILGRRVYDWAVQTEFERKVRELRRIRHERETAFEQLVGKINRDMEIRKMVVDVDPLVDEDVELPEDTSVVQKEPSEEALRKAHFERMEESLEPITDDQSEENSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYH7</accession>
    <name>A0A3N6LYH7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92924">
        <property type="protein sequence ID" value="RQG92924"/>
        <property type="gene ID" value="EA462_01500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="511" mass="57870" checksum="1DFC3658312A81C9" modified="2019-02-13" version="1">MDSSSGRDVESHEPVRNVVLVVLDTARASSVDLSATTDRPRTRSGPPEELPTPTLNRLAADGTAFEHAVATAPWTLPSHASMFTGLYPSEHGTHGDHTYLDPTLRTLPEAFSDAGFRTIGVSNNTWITEEFGFDQGFDDLRKGWQYLQSEADMGAVVRGEDIREKLEATRNRLFDGNPVVNAANILYSEVFKPSGDDGADRSTSWIANWLESRRGDRPFFLFCNFIEPHVEYDPPRAYAERFLPDGASYEEATAIRQDPRAFDCEDYEITEREFDMLRGLYRAELAYVDRQVGRLRNALEDAGEWDDTLFVVCGDHGEHIGEHGFFGHQYNLYDTLIHVPLVLHGGPFTDGGRRDDLVQLLDLPATLLETVDVDDPQLREQWSSRSMHPAARDPPREAVFAEYVAPQPSIDRLEARFGEVPDRVREFDRRLRAVRTAEYKYVRGDDGFERLHDVVDDPFERTDLAANEPERVRSLRGRLENRFEPLESAGSNEAIDMRDGTKERLADLGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYL5</accession>
    <name>A0A3N6LYL5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92964">
        <property type="protein sequence ID" value="RQG92964"/>
        <property type="gene ID" value="EA462_01750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="256" mass="28106" checksum="5607E5D016798C4F" modified="2019-02-13" version="1">MPVPEISAPLPRDILLGVLALSLLTAPLWAGAVGVGDPAYTYDRAEVTTTDAGIEYADPEEAPHRTPISDSIECAGWGGDIRACTFEEHLLEEGAIPTGIHATNPNSTSVPSVVQADYYRYVQIENTVYEPSYSPNTSAQREDGMYRVDMTLEPVAPEDALYWVSLGGDRAPSVVAETAREGTTTTTAEVDVPETPIRLEDETYYRVYQEREVDEPSTAESGLRFLLTYVAPFGSLFIAVRLSRRFHVSDTGRQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYR2</accession>
    <name>A0A3N6LYR2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR locus-related DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93014">
        <property type="protein sequence ID" value="RQG93014"/>
        <property type="gene ID" value="EA462_02035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010163">
        <property type="entry name" value="Csa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01884">
        <property type="entry name" value="cas_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="217" mass="23266" checksum="31A0F9003BE212F8" modified="2019-02-13" version="1">MRTYVSPIGFNTTSVTRTVLNQDLDKNDVVVLIRPEHGTDDDRASEAIADVEQLLQEIEPSVSVSIARIPHDDFSTAVMSCSDVLRAAEGSVIVNLGGGARDVVVPLTIATVAHAHEIDSMVGFSDIDGNVREWELPTIPSNTSRGATETLELIGEVSGSVSIPMLEQQCELAKSTVTRHVNQLETEGLVTSRTKDRTKHVEITLGGQLYLASSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYZ4</accession>
    <name>A0A3N6LYZ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93104">
        <property type="protein sequence ID" value="RQG93104"/>
        <property type="gene ID" value="EA462_02555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="40"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="831" mass="90925" checksum="AE4BA66294E6ABC7" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ63</accession>
    <name>A0A3N6LZ63_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87052">
        <property type="protein sequence ID" value="RQG87052"/>
        <property type="gene ID" value="EA462_15555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="238" mass="26113" checksum="40C8D25C2781A6A0" modified="2019-02-13" version="1">MSGFDRAEAVDRLEALVGTVENDRLPVPVREVWAFGDVALGLDPVDRLDIYLTKDILLRDDSQTVDGDGRDGMAGGEEGGTSPEARFRSSHGIEGVGKSVRADWAVEYPEHLRANANGHAAPEKCLAAHLLGEIDDEPIHLEVCNAPFEDNVTQRLRGAKRREDYTQLLDPRGVCLWVDGTRSDEAFRKLRESDLALPTLSDALEMLGLDGEEATDAARTLHAWRDDQEGVTVRGDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZC7</accession>
    <name>A0A3N6LZC7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88103">
        <property type="protein sequence ID" value="RQG88103"/>
        <property type="gene ID" value="EA462_14135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="50"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="274" mass="29663" checksum="739F9D9ACDCDC0D5" modified="2019-02-13" version="1">MALVLSLLGGALVIIGAYSVITPVPPQGDVSFTLEHYRRFFGTSYYLSVLWDSLVIAIGTTLLAFLLGYPAAYLLATTDSEHKNLYLLMLILPFWINVVVRTYAWRLILGSGGLVDWVLYDVTGVANESVQLLYSRGAIAIGLVHVFLPFMIIPIYVSLASIDRSGVEAAKNLGANRLVAFTEVTWPQSLPGVAAGVLLVFVMSFGAFVVPSLLGGRANIMIANVIGDMFGQLQEWGLGSAISMVFIVVVLTIVYVFNRWVNLGDVYGMGGDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0I8</accession>
    <name>A0A3N6M0I8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89150">
        <property type="protein sequence ID" value="RQG89150"/>
        <property type="gene ID" value="EA462_12325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="72" mass="8011" checksum="C940C289E332A010" modified="2019-02-13" version="1">MMPTNTRSVTVPNDLQSPRAKLVYLALVSAGEATTTELQNRFGLSKLTLLPILRSLVAKGLVRRTERGYHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0M8</accession>
    <name>A0A3N6M0M8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M24 family metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89190">
        <property type="protein sequence ID" value="RQG89190"/>
        <property type="gene ID" value="EA462_12550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="168"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="392" mass="43866" checksum="3576D3118D6B2C43" modified="2019-02-13" version="1">MSRHVFDEAEYERRVRRTTERLREAELDAIVVADPANMNYLTGYDGWSFYVHQAVVVTAERDEPVWIGREMDANGARATTRLEDASIRSYSDDHVHSPYDLHPMDYVAGVLEELDVADGRIGLEMDASYFTAKSYTRLQRNLPEADFEDATLLVNWVRIEKSDAELEYMRQAARISENAMRAGLEAIEEGVPEYEAAAAIYDALITGTDEYGGDYPAIVPLMPSGDHTGTPHLTWTDRPFEAGDPVIIELSGCRNRYHSPLARTTFVGDPPAELERNAEIVVEGIEAALEAVEPGVTCEAVEEAWRETIAQYGLEKEDRIGYSMGLGYPPDWGEHTASIRPGDETVLEENMTFHMIPGIWTEDIGVEISETFHVTGRGAEPLADVPRRLFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0T3</accession>
    <name>A0A3N6M0T3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diacylglycerol kinase family lipid kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89260">
        <property type="protein sequence ID" value="RQG89260"/>
        <property type="gene ID" value="EA462_10300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="348" mass="36883" checksum="66B8D88279F3F5F9" modified="2019-02-13" version="1">MGSDGTDGGRTDGDRVLVLNPVSGDETRVDDVVELARDHGFEVRRTERSGDGKRLAHEAAVDAGLVAAAGGDGTIHEVVNGVFDADALGSTTVAVVPTGTGNNFATNVGIEGIEHAFEAIDRGRRRIIDLGIANDLAFVNSCVGGLTAEASDETSSESKRNLGVLAYVKTTLQTARSFDSLPLRVESAVGPDGERGRTWDGEALFVLVGNCRRFNGTRTAQANVEDGLFELTIVEAASAPELLGDAAFERLFGRDGKHIVRLRTPSLSIESGGEPVGYSLDGEILETERLVLETNPGALEVVVTESYRADPDADGTPWPLGRQLERKASNGVRSTRSKDDTGFTSRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0T9</accession>
    <name>A0A3N6M0T9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89270">
        <property type="protein sequence ID" value="RQG89270"/>
        <property type="gene ID" value="EA462_10925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="112" mass="12040" checksum="E81722D31C92B5E7" modified="2019-02-13" version="1">MSTPLETVSADATVMEATQRMRETEINALVVRTSPRAIISSTDVLDAVAEGQDVTELVVSDVMTTDVETAAPDLYMEEVAAMMTTYGIKHLPVVDDDYVGMISSTDVTAHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M279</accession>
    <name>A0A3N6M279_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89211">
        <property type="protein sequence ID" value="RQG89211"/>
        <property type="gene ID" value="EA462_12660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043832">
        <property type="entry name" value="DUF5809"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19125">
        <property type="entry name" value="DUF5809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="136" mass="15247" checksum="8DC26CEADDCF772C" modified="2019-02-13" version="1">MHTVGTFDFESPEDARAAYESIGPAAQTVVREVARTMEFDREEYDERVTSDVVETARDALFASLLEVTVGSRAEYESWLESTDHDITEVGNENVDNVVWHAGPDERGVAATFQDEEDAAVATLRRQAFGRLYRDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2K9</accession>
    <name>A0A3N6M2K9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_08600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90050">
        <property type="protein sequence ID" value="RQG90050"/>
        <property type="gene ID" value="EA462_08600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="206"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="537" mass="57681" checksum="A045F673E952AEC7" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2M6</accession>
    <name>A0A3N6M2M6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="9">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lpdA</name>
        <name evidence="12" type="ORF">EA462_08705</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90070">
        <property type="protein sequence ID" value="RQG90070"/>
        <property type="gene ID" value="EA462_08705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="14"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="358"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG90070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="478" mass="49651" checksum="C85543084A37884E" modified="2019-02-13" version="1">MTPNSTTPTTETELLVIGAGPAGYVAAIRAGQLGLDVTLVERNSAGGTCLNHGCIPSKAIIHAADVANTAREADRIGVHADVSVDVTEIRRWKDRNVRRLTKGVEMLCDRNDVTLLEGEATFEDEKSVSVAGADGDDERIRFDRAIVATGSRAIELPGFSYEDEPILDAKQALELAELPDRLVVVGAGYIGMELSMAVAKLGVDVTVVEALEGMLPRYDEELTEPVERNAADLGIDFVFERAAAGWTQRQDGSVRVDLDTIGDGPPDDGADSIAGDAVLVAVGREPVTDSLALENAGIDLDSNGFVEGPNRFETSNDRVFAIGDVAGEPLLAHAASEEGTLVVESIATGEPIGAAAAIPSVVFTDPEIATVGLTGAAAADRGHDPVTGTFPFRANGRALTSNAGDGFIRIVADNSSERILGGQIVGPEASELVATIGLAVANELTVSELTAAVYAHPTLSEGIEEAALDIGGGAIHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3A8</accession>
    <name>A0A3N6M3A8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antibiotic ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90350">
        <property type="protein sequence ID" value="RQG90350"/>
        <property type="gene ID" value="EA462_07485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="406" mass="46226" checksum="BB632E24BC39A3B6" modified="2019-02-13" version="1">MPRSRALDRYVSVLDSTLEYSRRRGYAGPDYGDGMSSELLQAFPLENRLLNLGVQEIVKRTPVDVRPLLRVEHRRNYKGAALFAMANLNYHELACALGTRADVSFDPQAEAATLADWLLEERITGYSGFCGGHRHEIQHLHTKGVPSDPDIVSTTYAVRALLRAASLDDRYAEIARTASSFLVEDLNYREVSEGAKIDYHMNHPEDSYTLNSAALGAGMLVDLYADTGEDELRHRAARILDHVAAHQTEIGGWPYRLPADASHLSMDSHHNGFIIESFQRYRDVVDDGRYSDTLSSALEFYRNELFELDGAPNFDETNAYPRDIHASTQGMLVFTREGDLEFAERLLRWVLANLQVEPGRFYFRKHRYHTKRVTLMRWCQAWMSYAVSEFLLAASDRMATETDGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4D0</accession>
    <name>A0A3N6M4D0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="10">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hemB</name>
        <name evidence="13" type="ORF">EA462_15340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="10"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87017">
        <property type="protein sequence ID" value="RQG87017"/>
        <property type="gene ID" value="EA462_15340"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG87017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="338" mass="36764" checksum="BD97E68A225E3171" modified="2019-02-13" version="1">MNLTNRPRRLRQDRVRDLVSETTLEPTDLIAPVFVDATTDERIQIESMPGHERVPIDESVDRVEGVLETGVEAVMLFGIPSSKDSAGSRAWADDGVIQDAVRRITAETDAYVITDVCLCEYTEHGHCGPLEPGLADEKGGGTADHGSRESTLTVDNDATLESLEKIAVSHAEAGSDMIAPSGMMDGMVAAIRRGLDRAGFEHVPIMSYAAKYQSAFYGPFRDAADGAPEFGGRRHYQMDPANAREAMREVELDVDQGADVLMVKPALPYLDVVRDVSREFDHPVAAYNVSGEYAMLCAAADKGWLDLEEVALESLVSIKRAGADLILTYFAEDVGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4J2</accession>
    <name>A0A3N6M4J2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NosD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90151">
        <property type="protein sequence ID" value="RQG90151"/>
        <property type="gene ID" value="EA462_09180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42200">
        <property type="entry name" value="PTHR42200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Arch_flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NosD" evidence="2">
        <location>
            <begin position="432"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="705" mass="74308" checksum="DF5FECE6426EEE99" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5N1</accession>
    <name>A0A3N6M5N1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Histidine ammonia-lyase</fullName>
            <ecNumber evidence="3 6">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hutH</name>
        <name evidence="8" type="ORF">EA462_14510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88059">
        <property type="protein sequence ID" value="RQG88059"/>
        <property type="gene ID" value="EA462_14510"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG88059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="537" mass="57412" checksum="A6CF480C95596C76" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6L0</accession>
    <name>A0A3N6M6L0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88956">
        <property type="protein sequence ID" value="RQG88956"/>
        <property type="gene ID" value="EA462_11230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="70" mass="7997" checksum="219B9E4CFB41AC4A" modified="2019-02-13" version="1">MLNRYLRMQTSNGMSQSRSDQHHERVLVALEGRPCPSCHDGKLERSTYKENRAAVCDCCGTPQAQVWFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M711</accession>
    <name>A0A3N6M711_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89126">
        <property type="protein sequence ID" value="RQG89126"/>
        <property type="gene ID" value="EA462_12195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="178" mass="21080" checksum="E6545554239A6167" modified="2019-02-13" version="1">MRKSGPPKGLIAYLVFELLEEKPRYGYEILKEIEEISGGHWEPSYGSVYPILYKFEEKGWAKRIEREDEPDRKYFEVTDAGLEELSDRREKGSEKAEDFADVILGFFHVYAAFATDDRFQIPELEGEWRFDEAFSEWIVEQLARHHEHYFETAFERVEATPEEFSRRHGIDENDDQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M874</accession>
    <name>A0A3N6M874_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91561">
        <property type="protein sequence ID" value="RQG91561"/>
        <property type="gene ID" value="EA462_06280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="89" mass="10094" checksum="9C5C5B0D04918F5A" modified="2019-02-13" version="1">MNKHFHDSLYYLKRAGEHAKLGVESQLEPAIKRVRERLGNEPEPEQSRLEAVRSEVAGLEERTRGTIGGLRERVPAVRSTRESTGERNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M960</accession>
    <name>A0A3N6M960_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome-ba3 oxidase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92810">
        <property type="protein sequence ID" value="RQG92810"/>
        <property type="gene ID" value="EA462_00855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="6541" checksum="BFDE0A3D03AA1740" modified="2019-02-13" version="1">MVLEELSPRAALPVGLLALFPLIWYALGSSVMAGIVSTINVLLILACLYVAFSPVGGHSDAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M977</accession>
    <name>A0A3N6M977_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjbQ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90056">
        <property type="protein sequence ID" value="RQG90056"/>
        <property type="gene ID" value="EA462_08630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="15865" checksum="30F20EE670AF8022" modified="2019-02-13" version="1">MEIESHAFEVTSTDRWELTAITDLVEEAVAESGAENGLVFVSTPHTTVALFTNEYEKRLTEDIIGYFEELVPPEDGYLHDRHHVATETQLNAHAHIVCSMLHTPVFVVLEDGALRFGNWEDVLCFDTDGPSTRTVQVTIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9C3</accession>
    <name>A0A3N6M9C3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90116">
        <property type="protein sequence ID" value="RQG90116"/>
        <property type="gene ID" value="EA462_08970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043823">
        <property type="entry name" value="DUF5800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19115">
        <property type="entry name" value="DUF5800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="65" mass="7473" checksum="61C2E473738B9AC8" modified="2019-02-13" version="1">MTTLAFDDDGVDVVYEGTEFRLERELIEEATEKSYYDVTDHEVLKIVAQQPNLQGEPRRVGDILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9W5</accession>
    <name>A0A3N6M9W5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_02535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93100">
        <property type="protein sequence ID" value="RQG93100"/>
        <property type="gene ID" value="EA462_02535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="69"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="254" mass="28042" checksum="96E392C03CE65FC9" modified="2019-02-13" version="1">MAKHDRGEIQAVARAFGIVETLTELDGAGVSELARAVELPKSTVHNHLRTLERTEYVVREDGEYRTGLKFLQISETARNQHELYQVARPEVDHLAEKTGEISALLTEEHGRGVFLYRSRGSEAARIDTRIGDRVPIHCTALGKAVLAFLPDDRQDEIIDRHGLTAVNANTITDPRTLAEELELIRERKIAYDDEERLNGLRSVAAPILSGSGAVIGSISVAGPTHRMQGERFETDLPETVLGIANVIELTLEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MAA7</accession>
    <name>A0A3N6MAA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93260">
        <property type="protein sequence ID" value="RQG93260"/>
        <property type="gene ID" value="EA462_03450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="135" mass="14020" checksum="E5777F14CA02E9F2" modified="2019-02-13" version="1">MNRRAFLGMIGSVSTGLAGCLALLDVEGDEPNYISISNRYTDPVTIDVTITNVDTGKTVYDEVLGLDGFAGADVDGAAPRKRPDLGIGEGFEATVTAATDQDSDELTEDVGPSGGSSINVLHNSNAELSISRDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MAF2</accession>
    <name>A0A3N6MAF2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative [LysW]-aminoadipate/[LysW]-glutamate kinase</fullName>
            <ecNumber evidence="6">2.7.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysZ</name>
        <name evidence="9" type="ORF">EA462_03015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP</text>
            <dbReference type="Rhea" id="RHEA:41944"/>
            <dbReference type="Rhea" id="RHEA-COMP:9694"/>
            <dbReference type="Rhea" id="RHEA-COMP:9712"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:78499"/>
            <dbReference type="ChEBI" id="CHEBI:78503"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP</text>
            <dbReference type="Rhea" id="RHEA:52632"/>
            <dbReference type="Rhea" id="RHEA-COMP:13311"/>
            <dbReference type="Rhea" id="RHEA-COMP:13313"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:136714"/>
            <dbReference type="ChEBI" id="CHEBI:136717"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the acetylglutamate kinase family. LysZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.17" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93320">
        <property type="protein sequence ID" value="RQG93320"/>
        <property type="gene ID" value="EA462_03015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00036"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043744">
        <property type="term" value="F:N2-acetyl-L-aminoadipate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02082">
        <property type="entry name" value="LysZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037529">
        <property type="entry name" value="LysZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG93320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="290" mass="29729" checksum="810F0A6FB85E5D1B" modified="2019-02-13" version="1">MTVVVKIGGARAVDPEGALVDVASLVDEGEDVVLTHGGSTAVDETLEELGQEPTYVETPGGIVGRFTDEETMDVFKMVMPGKLNTDLVESLQNEGVDAVGLSGTDGKLLRGKRKSAVRIKEDGKKKIKRGDHSGTIESVNASLLETLLAGNYTPVVSVPVLGTEKDGGYTAVNADADRAAAAIAGALEADLVVLTDVSGIYADPDDESTKFDSASTPEEFDAVKDAAEGFMTKKVMAASEALEGGAASVTVATANADEPITSALAGEGTTLEPGVLANGDASETPQEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC88</accession>
    <name>A0A3N6MC88_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91316">
        <property type="protein sequence ID" value="RQG91316"/>
        <property type="gene ID" value="EA462_04860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="163"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="229" mass="25567" checksum="8541A1DDE5D73434" modified="2019-02-13" version="1">MTTVVELEIPADRLGFAQTFDRVPTFEFQVAGMIGDAPPLVRASGSDSRTVENALEGDPSVDVIASLTDSERPDPTREDGTRDQWLFRLEFGDGVKLFQEIVTENDGAILTARGRDTTWSVQLLFHEHETVSACHELFEHYEYQVNVTRVAGFDDLDRARTPLTDTQYETICAAHELGYFDVPREITLQELAAELDISHQALSERLRRSHAALISAELSEGLTTSEIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCU9</accession>
    <name>A0A3N6MCU9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_06435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91586">
        <property type="protein sequence ID" value="RQG91586"/>
        <property type="gene ID" value="EA462_06435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031604">
        <property type="entry name" value="Ferredoxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16947">
        <property type="entry name" value="Ferredoxin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="537" mass="59029" checksum="7547F1AA4E0E5268" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFW7</accession>
    <name>A0A3N6MFW7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92816">
        <property type="protein sequence ID" value="RQG92816"/>
        <property type="gene ID" value="EA462_00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="259"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="499"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="675" mass="76607" checksum="9031115FEF6DBC08" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MR04</accession>
    <name>A0A3N6MR04_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86663">
        <property type="protein sequence ID" value="RQG86663"/>
        <property type="gene ID" value="EA462_16095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="143" mass="15303" checksum="BC8794179DFD2D31" modified="2019-02-13" version="1">MHVLVPLDGSQQSWAAFDHALSTAEGAITALHVVNPADGVYSDYDGGGYYDPETHQRTRERGDELLAQARTRAEEARASEAIVLESAIETGPPARTIVEYARDNDVGRIVMGSHGRSGVARILLGSVAEAVARRAPVPVTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MZV5</accession>
    <name>A0A3N6MZV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_03865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91142">
        <property type="protein sequence ID" value="RQG91142"/>
        <property type="gene ID" value="EA462_03865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="3">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="179" mass="20303" checksum="632F7D7BBAC2208C" modified="2019-02-13" version="1">MEQVFAPWRIEWIRRDDKNADIDDCVFCELPERRADRDNLLVARSERTFVLLNNYPYNPGHVMVIPRLHTGDYGDLTDEQLLDHARLKRRTFGALETALEPDGFNAGLNLGDGAGGSISDHLHTHVVPRWRGDTNFMPVLSETSVIVEALEETYDRVHEAFARQDGATVPGERSAVVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N186</accession>
    <name>A0A3N6N186_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91722">
        <property type="protein sequence ID" value="RQG91722"/>
        <property type="gene ID" value="EA462_06145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="521" mass="54878" checksum="ADA81F6561394FAA" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N193</accession>
    <name>A0A3N6N193_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_06660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91732">
        <property type="protein sequence ID" value="RQG91732"/>
        <property type="gene ID" value="EA462_06660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="16"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="557" mass="62177" checksum="1B8DB3CE90845AF9" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4V3</accession>
    <name>A0A3N6N4V3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93222">
        <property type="protein sequence ID" value="RQG93222"/>
        <property type="gene ID" value="EA462_03240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="212" mass="23871" checksum="BA116B77DE86ACFC" modified="2019-02-13" version="1">MGLFTELKDSISRATDRLFSEQEPKRIGIYGPPNAGKTTLANRIARDWTGDAIGTESHIPHETRRARRKENVEIERNGKTVTIDIVDTPGVTTKVDYEEFTDEMDEDDAIRRSREATEGVAEAMHWLREDVDGVIYVLDSAEDPITQVNTMLIGIIESRELPVLIFANKIDLDDSSVKRIEDAFPQHKTIPLSAKEGENMDEVYGSIAEYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUC6</accession>
    <name>A0A3N6NUC6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86760">
        <property type="protein sequence ID" value="RQG86760"/>
        <property type="gene ID" value="EA462_16635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="908" mass="96610" checksum="6E9D5C8376D30DED" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVP3</accession>
    <name>A0A3N6NVP3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87932">
        <property type="protein sequence ID" value="RQG87932"/>
        <property type="gene ID" value="EA462_13805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="104"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="352" mass="39586" checksum="0B9E963ED4ADD4D8" modified="2019-02-13" version="1">MDGYEVVDADAHYFETLDHIAPYLDEPWKTRLSQKIDSPQSSIYPTSSGDRNVFGRIARDELSLSDMTPEDIPMIMDHLDVDKTIILSQKMLSFGRIKGDDERPVILANGYVDYMLDKVVDPDEGVYTMIPAPYQDPQAAADLIHRVGDEDGICGVCLVTPGAEPPMGNRRYDVIYEAAQKEGLALNFHAGGGGLDEFHIKGYEKFIETHTLGFLMNNMAQLTSVVVQGVPEKFPDLEIAFQESGIFWVPLMMRRLDAEYLKRPSEAPLLEKRPSEYIKEFYYGIQPLEVPENEAELEGVIETIGGASQLMYASDYPHWDYDLPEVISERPFLSDDEKARILSGTANEVFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYK9</accession>
    <name>A0A3N6NYK9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86142">
        <property type="protein sequence ID" value="RQG86142"/>
        <property type="gene ID" value="EA462_16860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="461" mass="50990" checksum="F92B7F3BB35B8740" modified="2019-02-13" version="1">MEHVDVAIVGGGPAGASAAERAAAHDAEVVLFEQGVPREDRDGPGPDSTDAAGMLDYWIDIMDFDYEEIPDDVILQELEGTEFIGPESSVELATTGIDARYPKFGYTFNRTRMDDWLHERAADAGADLRVGIGVSDLETDLRASSANGPTHTLSLSDGSQLEAQYVVLADGPQRRITLDALDQFTAPGRSVSDYLSPPEANHIAYQEYREFPEELFDDDWLTFWWGYMPGETAYPWVFPNDGTVARVGLTMPIGMRLEDVDNPGSYKLLEPTDDGLPSGSEYITRLLEHEYGDEYDVETDFPLVEDRGKSKGTETYPISSTRPIESPVGANIAVAGGAMGTTSAFHEGGYHVAVRSGKIAGRLAATDSLENYNDRWKNAIGDEILRNVAFADIVKDYEPDDWDWAFDVVTDMQRGGGDNVLISKRYSAGLDATRIVAAYKRRKFTYRDGRYVQLTENDYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYL0</accession>
    <name>A0A3N6NYL0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89929">
        <property type="protein sequence ID" value="RQG89929"/>
        <property type="gene ID" value="EA462_07930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="432" mass="44895" checksum="4C95E51439A62B06" modified="2019-02-13" version="1">MRFARIVPVALLCIVAITGVAVVAGAPPPTQLCDVCASDVDGATGPGTLDVSVDSNGDSRWTERVPITDSAADRYREEPKTLEREIEDGRSWHVARGETADRTVSLEDGGVVVTYTVDAVARPGVGGTWLVDYFALDSGNERYDLAAERVRIHTPPDTDVITEPRYATVDGNTATWNANAGESIGGDFASQTYLTHGSNGVRGTALGYATIGLEIGPQALKLGVIVGIAPAILIAVSGLAIGRVDRGRASFDRPRLERLIVGIGLVGALALVLVSLVTTGRPLTPGIGGVSSLGIGYALLGIAVRGGGDRLEIRGLAGLAGFAAAVSGILMWLVGDWSVTILLPFALATGLFLPIGYAYGSRSRPVGTVILAGILPVLGGIVLFSFVLPTVIGTIVYWFLLAFWGGITVAFGYPLSLLGRKLAEEETADAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYP3</accession>
    <name>A0A3N6NYP3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_17075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86182">
        <property type="protein sequence ID" value="RQG86182"/>
        <property type="gene ID" value="EA462_17075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="4">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="224"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="497"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="754" mass="82743" checksum="F2DC3670F1924992" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZH8</accession>
    <name>A0A3N6NZH8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma carbonic anhydrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86956">
        <property type="protein sequence ID" value="RQG86956"/>
        <property type="gene ID" value="EA462_14965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="166" mass="16954" checksum="16CC930C2FCA394F" modified="2019-02-13" version="1">MLRSFEGTEPQVAEAAYVDEAAVVIGDVVVEPDASIWPNATIRGDHGTIVIGEAANVQDNAVLHEDAELGSRSTVGHSAIVHGATVAEGALVGMNAVVLDGSHVGEGAIVAAGSVVTEGTEIPPSTLVAGTPAEPKGEIDDPRLEATADRYASLATRYAESSERVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZS2</accession>
    <name>A0A3N6NZS2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_15705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87076">
        <property type="protein sequence ID" value="RQG87076"/>
        <property type="gene ID" value="EA462_15705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="8"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="27791" checksum="991F0101A0B48259" modified="2019-02-13" version="1">MSSTPRAIDADGLTKRFGSATAVDGVDLAVERGTVYGFLGPNGAGKTTTMRMLTTLTRPTAGNAWIAGDPVTDRGAVRDSIGYLPEEPPVFDELTGREQLEYTARLREIPRERSQRRIDGWLERFSLSADAGKRIDDYSKGMRQKIGLVQALLHEPAVVFLDEPTSGLDPRAARTVMNAIRELADDGHTVFLSTHILPVVEELADTVGVLFDGRIVTEGDPDELTAQIESEADSTLEDVFLTVTTDHGPTVSEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1C2</accession>
    <name>A0A3N6P1C2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonine synthase</fullName>
            <ecNumber evidence="2">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91289">
        <property type="protein sequence ID" value="RQG91289"/>
        <property type="gene ID" value="EA462_04695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="1">
        <location>
            <begin position="74"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="396" mass="41607" checksum="9126F013782731D2" modified="2019-02-13" version="1">METTDAFVGLECLDCGASHEVEEKRRCPDCGGPLDPSYDYDSISLERATIESRPFDSLWRYEEVLPFSRETAVTMDEGATALVECPSLADELGVERVMIKDEGRNPTGSVDDRGASVAVTAAVRRGASDVALASPGNGGQAVSAYAGRAGLESHVYLPSRSGFTNKAMVNVHGGDMNVVGGRFDDAVGAFEEGLSEHDDWHSLQAVSTPYRHEGAKTLLYEIAEALEWNVPDVLCCPTGQGTTLLGAYKGAMELQALGLVDELPSLYAAQAAGCAPIVDAVEAGRDEHDPVETPDTICGGIEIPDPIAGRRMLEAIRETDGGAVASDDQDVLEAGVQVATHEGVAMVPSAAVAASAVWNLAEGGEFDGDETVVIVNGATGNKEADVLRSYLMSQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1C5</accession>
    <name>A0A3N6P1C5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_10725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88865">
        <property type="protein sequence ID" value="RQG88865"/>
        <property type="gene ID" value="EA462_10725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="21"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG88865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="482" mass="51457" checksum="8560BFDCFD46DC2C" modified="2019-02-13" version="1">MAIATEERYNLFIDGESVDGSDEEYLTTTDPATGDEIAQVAAATSEDVDSAVAAARESLSTWQSKSPIERGQIVHSIAERIRESADELATIESRDQGKPLAQARDDIKGAARYFEYYAGAADKLEGDSIPLGDDKLDLTTREPYGVSGQIIPWNFPLSITARGVAPALVAGNAVVVKPAPTTPLSALHLAEICADAGVPDGVINVVPGGAEPGVALSSHDDVDQLTFTGSVPTGEAVMQSAAETITPVTLELGGKNPAIVMPDADLDEAVFWISTGIFTNAGQICSAADRALVHESIYDEFIERIVNRAESYTLGSGTDDPDMGPLNHAEHFESVLEYIEMGVDEGATLETGGDPLDRDGYFIPPTIFSSVDNEMRIAQEEIFGPVLTVIPFSDRDEAITIANDVEFGLTGGVFSRDIKQALNMAREIEAGSVYVNEWFGGSTETPFGGMKKSGIGREKGLEALDSYLQTKNISVNLDERNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1U0</accession>
    <name>A0A3N6P1U0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91509">
        <property type="protein sequence ID" value="RQG91509"/>
        <property type="gene ID" value="EA462_05985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="5"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="339" mass="37505" checksum="346A9CBAAA760AA4" modified="2019-02-13" version="1">MTNVLVTGGAGFIGSHLAASLLEAGHTVTVLDPLDPYYDLRIKTHNLERCREIGGDCFQFIDGSITDEELVHSVVSSHDIEVVYHQAAQAGVRTSVENPKKPHEINTTGLLTLLLAADEHGVHRFVNASSSSVYGEVEYLPYDEDHQTVPRSPYGVTKLTGEHYCRLWNEIYDVPTVSLRYFTVYGPRMRPNMAITNFTSRCLNGDPPIVYGDGQQSRDFTYIDDIVDANLSLLETSDCDGEVVNVGSTRTITIEELANHVIAETNAAVGIEYADAREADARHTHADVTKAGELLDYEPTTGIRDGVSQFVDWYRSNREWYEPLVFASRAGESSPSQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P242</accession>
    <name>A0A3N6P242_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerol-3-phosphate dehydrogenase subunit GlpB</fullName>
            <ecNumber evidence="5">1.1.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glpB</name>
        <name evidence="5" type="ORF">EA462_12630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89205">
        <property type="protein sequence ID" value="RQG89205"/>
        <property type="gene ID" value="EA462_12630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009158">
        <property type="entry name" value="G3P_DH_GlpB_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000141">
        <property type="entry name" value="Anaerobic_G3P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03378">
        <property type="entry name" value="glycerol3P_GlpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="6"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="436" mass="46095" checksum="F762D22E75590C05" modified="2019-02-13" version="1">MAIEDDVLVVGGGIAGATAALAALETDPDARVRLVTHRQSTLRHASGLIDVLGYTPAGEGPLADPFDALEALPTGHPYERVGTDAVREALAFFDRVVDGAYEGGHTDRNALVPTYGGTVKPTARYPASTAPGLASDTRETLLVGFETLPDFDAPLAARHLEAAGVPFDARGVTLSFPGIRRDDAKITRYAHLLDRDEVVDADSGERSARDALAASVDTHLEDESRVGFPAILGDDRVETVREELAEALGVDVFEVPMGPPSLPGMRLEGLLYDALEDAGVRLTSGVPVVDYETTAETAGGTTDRIDHVVVDRNGAEVPHRADQYVLATGGLVGKGVDSNRERVYEPIFDCHVSHPADRYDWFVDDVFGDQPYARFGLEVDRDLRPLAADGVPEFSNLSAAGAVLGGYDFAAEKSGSGVSLATGYVAGTRAAEVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P2A0</accession>
    <name>A0A3N6P2A0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91699">
        <property type="protein sequence ID" value="RQG91699"/>
        <property type="gene ID" value="EA462_04635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="357" mass="38663" checksum="89FAA50E3892EFDB" modified="2019-02-13" version="1">MSSSDREPALESHGADIGKRTNSLARVRDWVLVDGDRIFVSTLISVAAFLVFLGLGELGIISFVNDDSITRLAGGMIAGTFSLVTLVVSINQLILSQEFAAAGESEDQLEAILSFRADAADATDVPAVPASPTRVLELLVETIGDRARTLAATVDHRDDEFATRVRRYTNSIEESAERADETLEHTSFGTFRAVSAAIGYDDDWQLYVARHLRGREDDLPDEARDALEELIETIQLFSVAREQFKTTYLQRELTRFSQLTIYCGVPAILSAMLIGFLYADIGGASISLGYLPIVVSALIAVVLSPLALLTSYILRTATVTRRTASVGPMLPQKDPDAGPFDVGSAEESEPNARTGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3N7</accession>
    <name>A0A3N6P3N7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89935">
        <property type="protein sequence ID" value="RQG89935"/>
        <property type="gene ID" value="EA462_07960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="390" mass="42807" checksum="8A3E5D3C77163CFA" modified="2019-02-13" version="1">MPETNTARLVHRLATLRERLQPEMDRREFLRTLVTGGYALGMAQLLGVEDFLAADDGEVPIVTARVRENPDDPFSLVEQTRDVPAEWYAAVQNAFELNERLARIAYTGYLGSAVVPGDYASGTASISIGVSNEGQSAREMIRDVSEGISINTETIIEIEEIEDGFEYAEPRYVESVDDGRVPSGIACETPSSLATLSPALYHPDEEEAFFVTAEHAFKDEPDPVGHPLALPLDRVERLELGTVVYAHPGEDFVAVEPNGEMRPVSRIAAPSPVRVRGQYTRLGLADLVARGEELEKVGALTGHTTGRIQGVDAVTCFTDEFCRRGQIRWGGEMDLTDGDSGSVSYHSDPDGRDDDVLVAGFNNARTWWPGQSYVWGVSAYKLTAEHGYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4F4</accession>
    <name>A0A3N6P4F4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-3-methyladenine glycosylase 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90265">
        <property type="protein sequence ID" value="RQG90265"/>
        <property type="gene ID" value="EA462_09815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="49"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="203" mass="22622" checksum="F3EE6A5CE29178AA" modified="2019-02-13" version="1">MVEPDTETSQDGASVLGSDPVLAAVMDRHDLDPLEPAENEFKRLCVSIINQQLSSASAAAVRDRVFSVLDDEVTPDAVLTASSDDLRDAGLSRTKVDFVRNAARAFLERDLTRSGLADHADDEVRAELTRIAGVGPWTARMYLIFVLQRPDVLPLGDLAVRRGIETLYNDGQELTRAEMREIARPWRPHRSLATRYVWAEYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6G0</accession>
    <name>A0A3N6P6G0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91365">
        <property type="protein sequence ID" value="RQG91365"/>
        <property type="gene ID" value="EA462_05155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="63" mass="6785" checksum="5EA25950D4FA1E22" modified="2019-02-13" version="1">MLPNTSRLEESDRSGSKAWESVSNRDGSDSTGDGEQTQIDGHDEWIGIEPPGRLLVPLAGFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PAA7</accession>
    <name>A0A3N6PAA7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 10">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">upp</name>
        <name evidence="11" type="ORF">EA462_01655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 10"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93295">
        <property type="protein sequence ID" value="RQG93295"/>
        <property type="gene ID" value="EA462_01655"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_A">
        <property type="entry name" value="Upp_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034331">
        <property type="entry name" value="Upp_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="10">
        <location>
            <begin position="145"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="10">
        <location>
            <begin position="214"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG93295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="224" mass="24565" checksum="6E97721EACD3A5E4" modified="2019-02-13" version="1">MPIENRENAYLITHALAKDTLSRIRDVETEQVSFRKGLVKLGRICGYEIIDGRMETEYVELETPLETTMGERVRGLDDVVIINVLRAATPFVEGLLKAFPRARQGVISASRDEEAGRGEDGSFPITVDYVKLPEIHEEDTVIVADPMLATGSTMCTVLDHIDGSADPENLFVLSAVSAPDGLLRVDESFPDIDLLTVSIDDRLDDNGFIVPGLGDAGDRAFRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PAC2</accession>
    <name>A0A3N6PAC2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyrrolo-quinoline quinone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93325">
        <property type="protein sequence ID" value="RQG93325"/>
        <property type="gene ID" value="EA462_03120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PQQ_3" evidence="2">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="2">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="2">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="371" mass="40100" checksum="3BB26382112E1155" modified="2019-02-13" version="1">MTAWNQFKRDRRNGGQRRDVEGPHRVEEAWTVDLVGPVGSPVLDRDTVFVGTSRGNVYALDREDGRRRWVFETMTATDVTPVVTREAVHVGTKEGTIYSLEPATGEQRWEADLPGSHTTALAVSDGQLYAGHTAGCSALETATGAEVWTHETDAPVAGSPAIDDDREWSQPRVFVGTDDETVLSLESESGEESWSVPADGAVTDGPTVADGRVYVGDDGGTMLALDGETGQSWFTYEIRGAFTSSATVLGDESETEEEDGTTFIGADDGYLHVTGTTFGRRKVRGWLFAKKGIALDGEVRSSPIVVGDVVCVGDSTGSLYGIDAEEFDHLWHFRTEGPISSTPAVGNNRLFVGSEDERLYCLEWTPGDPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHX1</accession>
    <name>A0A3N6LHX1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_16000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86649">
        <property type="protein sequence ID" value="RQG86649"/>
        <property type="gene ID" value="EA462_16000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease_alpha" evidence="3">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="4">
        <location>
            <begin position="52"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="464" mass="50468" checksum="4407C2DC997AB384" modified="2019-02-13" version="1">MAVETVVTNGTLVSSTGTTDADVAISDGKIVAVGDESNLPRAAETIDADGCLVMPGIVDPHVHFDGPNPRFDGPAETYETGSKAAALGGVTTVIDFAWQGTHRGDDEQPGTLRDGITFQKNTADESLIDYGLHATITREDPALFEELPTVVDGGVTSFKMFTAYDWGVSNGFMGRVFERLSDLGAVAILHTEDDSVCTEQATVLEQEQRGDPTDYPSSRPAYAEAMAADNALRMAVESDCKYYGLHTSCEKAAAVIERYRRKFGDGLVRGETCTHYTTLDRSLYSEIGTLAQLAPPLRSADDVESVFDHLVRGTLDVVSTDHVAYHRSAKRADDWWDSSYGVNSLQHSLPVFYDEAVKRRTCSPSFVVRTMSTQPARLFGLEGKGTLEPRTDADLVVFDPDSRDTISATDNASEADYSIYEGRTVGGEVIHTMVRGELVVRDGQLVGEPGHGEFVARTTPDWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJB8</accession>
    <name>A0A3N6LJB8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87991">
        <property type="protein sequence ID" value="RQG87991"/>
        <property type="gene ID" value="EA462_14125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="368" mass="40628" checksum="C5771B5A10FB2C8B" modified="2019-02-13" version="1">MYTRRSLLRTTGVATVATAGLAGCLGGNGDDEDETSGEDELADEVNVAIYGGAMGDGISETILDGFEDEYDITVNAETYPDNWDLIAQVQAGSTDLDVLILDDTAVPSAVSDDLVQPIREENVPNLDEIMADFSPYEQAFDPGDEIHYGPFQFFGDGLAYNADVLSEPQSWEDVYTDETEGSVIYTSWIDRVVGIAASHEGLSVSELDQDSDAEMEQIWDRVESMNEYVFEWADTGGILQDSFANEQALAGMLWYGRVAALQDDDVAVEYTIPEEGAPMATSGFSVSADTNRRYTAETFIDYTLDPDTQYEYSSVMGYAPTAEMDEVPELVENSPDYQNRDRLNFWNASLLVENMEEWSLEFQETIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK61</accession>
    <name>A0A3N6LK61_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="1">TMP kinase</shortName>
            <shortName evidence="1">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="1">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">thiL</name>
        <name evidence="4" type="ORF">EA462_12230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89133">
        <property type="protein sequence ID" value="RQG89133"/>
        <property type="gene ID" value="EA462_12230"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="134"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="303" mass="31839" checksum="F23716D714F8D11C" modified="2019-02-13" version="1">MDERAVLALLERELEAAGDDAAVVDDLVITTDMLHERTDFPSGTTRYTAGWRAVGASLSDVAAMGATAIAAVAVYAAPELDRDEVLAFVRGAREVCERVGAEYVGGDLDGHDEFTVTTTAFGRTDDPVLRGGARPGDRLCVTGTLGRSAAALELFDRASETDSAADADRLRERANELFRFEPRVDAGLALGAHATAMMDSSDGLARSLHQLSEASDCGFAVDAGDVPIDDALFEVSADDDEALERATTFGEDFELVATVPEDALEAVRAATAVPLSTIGSVRKPGDGITIDGDALEDRGFTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK82</accession>
    <name>A0A3N6LK82_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NifU family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89163">
        <property type="protein sequence ID" value="RQG89163"/>
        <property type="gene ID" value="EA462_12410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="2">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="118" mass="12529" checksum="BB6FC0FA1ADA6008" modified="2019-02-13" version="1">MSTETQNDGDDLEERVTNFLRRNFPQIQMHGGSAAIQEIDRETGEVTIALGGACSGCGISPMTIQAIKSRMVKEIPEIEKVNAHTGMDGGGDMGDTSPSFPGETVDDGEVDEGPEAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKV2</accession>
    <name>A0A3N6LKV2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4242 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="RQG87128"/>
        <property type="gene ID" value="EA462_15180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025336">
        <property type="entry name" value="DUF4242"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042557">
        <property type="entry name" value="SCO4226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14026">
        <property type="entry name" value="DUF4242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="79" mass="8996" checksum="70C702E44D17E10A" modified="2019-02-13" version="1">MDVHRNVEGMDAQAAMDAHEMDVEIQGEYGVEYERYWWDEDAGAVFCLFEAPDKEAGEKVHSESHGLTADEIYEVQEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLD7</accession>
    <name>A0A3N6LLD7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87910">
        <property type="protein sequence ID" value="RQG87910"/>
        <property type="gene ID" value="EA462_13690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="295" mass="30729" checksum="3312BD8B700C38A1" modified="2019-02-13" version="1">MSNLAGIALAVLAALGLSIAVICIRIGTDDGRSVDALVVVLLTNIAILVPVTLALQNPLSGLTRTSLVSFAMAGLVGTFVGRAFFYASIERVGASRSEPIRASQPIYATLAAVIVLGEVLTPEHFAGILLIVLGVGAISWETASGSVQQTGRSYDLAFPFVAAFFYGIEPIFAKIGFATGTSVLVGLSIKTVVATAGFLAYLRWRNALPTSTELASSSLRWYVGAGIANTVFLLGYYAALEIAPVVLVVPIIQISPLLVAVLSFVFLKRLETVTVPLILSAVVVVVGGILVSIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLH8</accession>
    <name>A0A3N6LLH8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89843">
        <property type="protein sequence ID" value="RQG89843"/>
        <property type="gene ID" value="EA462_07445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="103" mass="11368" checksum="2B5AE495B7E9FB74" modified="2019-02-13" version="1">MSGDIVRIDEASLFELLTVGSLFLVAVLGTLIAYQAYRGYRRNGVPSMLYLSIGLLLLTLCPFLINVGINTLVDTARIVTVFFENVSRLLGLVAIMYSLYGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLQ4</accession>
    <name>A0A3N6LLQ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89818">
        <property type="protein sequence ID" value="RQG89818"/>
        <property type="gene ID" value="EA462_07305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="280" mass="30291" checksum="28C3E5CB244872AC" modified="2019-02-13" version="1">MKWRCTWCGKPHEENDPPCDECGHNAFERAVVRAGKEPRNSPARTVDTGTPYVWRCSNCGRDHVKNNPPCSRCGNPELEKTEQTYADVDRDLETPSWLEVAKPYMPIFAVIGIVAVLFATGIVSPTIIPGIGSPAPPDAPGEGTQAAGIDLEVTANEVHERLESERATSGEPREYDGALAAYAEYQNRAFVSVEYEDERPGLADPGEFGADCHGEPIGGQLSLDGPTIQEYADEADLADDITDRLLVSSIGDDVRDGYDGEGIDVHVGPGGDVYVYYATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLT2</accession>
    <name>A0A3N6LLT2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89993">
        <property type="protein sequence ID" value="RQG89993"/>
        <property type="gene ID" value="EA462_08275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="405" mass="43669" checksum="6D4D4DA5A76FF034" modified="2019-02-13" version="1">MNRFTRRDVLLTTGSFGAITVSGCLNDPSTGDGNGGSGGNGDGNGSGNDNSVDNGDASFDTFQLGPSLSRPLWAERADDPPGFVTVIETERDEPWMVDDPDEIDGLEEWYGETDFDESVIVFVGTVGPNTCYSEVDVDDVTISTVTLEGEDSRPAITAAARPVDTSDEDEACGEAVTYPSAFVRVTGDDLPSEALFTVTNGWDETDDVDSAGGLIDPAELPGFVRPPHDPETVPEALSCDEDEFERHWSPDDEISWGETTDDDGSPKLSLRAENAEYSGDDAAEALEFGRGDEIRIRMRNVSDRPVMTGNRNKYNLEVSTEDGWADVRGTTDDDPIDYTDEGVVHSPGDGFEWTIELTEAGILSASAHEDRFEICPDLPDGRYRFVFRGTSGDATLAVAFDYGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMA9</accession>
    <name>A0A3N6LMA9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86645">
        <property type="protein sequence ID" value="RQG86645"/>
        <property type="gene ID" value="EA462_15980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013668">
        <property type="entry name" value="RNase_R_HTH_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08461">
        <property type="entry name" value="HTH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_12" evidence="2">
        <location>
            <begin position="29"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="115" mass="12991" checksum="9820398E0C2D7289" modified="2019-02-13" version="1">MCGYHVSRTMSQGRDDAGRFEESVTEQDILKVFDYEDDPVLTAPEVADGLRRFGKQITPEGVRNRLAEMDEKGLVSRKKLGARAVGWWAEVAPELDSSTAKTIDSRKESDEWEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMG8</accession>
    <name>A0A3N6LMG8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90293">
        <property type="protein sequence ID" value="RQG90293"/>
        <property type="gene ID" value="EA462_09960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="201" mass="21708" checksum="1435A79BBCFAFE4B" modified="2019-02-13" version="1">MTLMVDIRKLSFINEMAKVGTNGVAENMGKLTGENAQMDVTKTNFIDIDDIETQLEPGKRVGVRVRLLDPPHGHILVLFPEASAKKITAIMLSDVVDDMSDVSGKMARSAVEEMGNMMASGFIDGWADVLGRVIDIAAPQLVYAPGGDIVTRTAALGGDDLALLFDSDLTVPSYQIEAEIYAFPDLEEFVEMVNGIDVQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMH5</accession>
    <name>A0A3N6LMH5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89017">
        <property type="protein sequence ID" value="RQG89017"/>
        <property type="gene ID" value="EA462_11585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="122" mass="13245" checksum="F2916D5AB383D364" modified="2019-02-13" version="1">MVELETTTCRINGVTLVSATVANPQTTPQRVRLESRIEGPTWPPRRRGSIAPEWNGNRWESTVAPKRRCGLGFATSVETTDPPIELVSAIRASDRTRSSPDAVLASLAESAPSRDVVSSFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMM2</accession>
    <name>A0A3N6LMM2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86795">
        <property type="protein sequence ID" value="RQG86795"/>
        <property type="gene ID" value="EA462_16820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="420" mass="43827" checksum="A072EAF2DA53B120" modified="2019-02-13" version="1">MTLSDNDRQIATFTMLAHGIVHWFELAIPIFLVVWLEAFDVSVSLVGLIVALGYAPFGLGALPAGLLADRYGPKRLILVCLVGMSAAFATLAFAPSIYAVAASLLGWGILASIYHPAGLALISTGVEDRGTIFAWHGIAGNVGIALGPFATATLLLAFEWRVVAVMLAVPGLLACLYGLHLEFDPTAATAAEDAAAAGSRSRSAVVANTRSLFASSFLLVFVVVTFVGLYYRGVLTYLPELLHGLPAMDGVEPPVGLEELSLGDYFYVGLLVAGMAGQYVAGKLTNRVAVARGLIVTFVALGVLAVAFVPVASMGLGVILLYCAVLGFSLFAIEPFYQEAVAVYTPPDTRGLSYGYTYLGMFGLGTLSISFGGFLIDYVTVAAFFAVLSVIALIGAAVGGRLLIAPSYSATQGPETPSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LN73</accession>
    <name>A0A3N6LN73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87035">
        <property type="protein sequence ID" value="RQG87035"/>
        <property type="gene ID" value="EA462_15455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="66" mass="7439" checksum="4B109A6535A009B2" modified="2019-02-13" version="1">MTRDQPGDGSITNADDFEAALAEVVEKAVEADVDVRGAWEFRTRGSIHEWEVEIIELARYDDQEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNV0</accession>
    <name>A0A3N6LNV0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_13470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87867">
        <property type="protein sequence ID" value="RQG87867"/>
        <property type="gene ID" value="EA462_13470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="271" mass="29718" checksum="76D4EA994893E7B0" modified="2019-02-13" version="1">MCAQLLSKRKLTQYRKQLNGTHARVGGILFGLLAWFVLASVFPANLMPYPFETLVLTAELIQSGAAFSHLFVTLWRTLLGFLGAFILGGTIGVLMGVSNYGEKFFVPYIVIGLSIPAIAWAAISTLSLGLSPMAPVVATIATTFPFIAINVWKGVQNIRTDLLKMSSAFGVSNPRLLRRVILPNTAPALFSASRFGLAISWKIVTIAEIFASSSGVGYMLIRAYESYQYELAWAWAVLFMIVILLIEYGVFRQLEKRAYAYRSATDVVGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNY7</accession>
    <name>A0A3N6LNY7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89767">
        <property type="protein sequence ID" value="RQG89767"/>
        <property type="gene ID" value="EA462_07035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="491" mass="53265" checksum="B5605E94DBFEF413" modified="2019-02-13" version="1">MPPGNAGREGPDGSSRRRFVRSVSATAIAGGAAIAGCLGRTRDEETVVMSGDTDFEGIMHTDDGEPSVQEALWDAGLPEEITVEVQASVDDSAQRMQQYQSALQAGRSPPDIFMMDSGWTIPFILREQTINLTDALPANVVERVERDYLEAAVETARHPQTGDLHAVPLFPDFGTVLYRRDLLESAGYDTSEWDADPPTWQEFSNAVSDAQNEAETDFGFTTQAAAYEGLACCSFVEVMSTWGGAYFGGTDTLFTAGDRPITVDEEPVLEAIRMMRAFVHGEDDEYALEGYPQICPSAIVQWSEQESLDPFANGDAIANRNWPFAIAQTGAEDAFGEDLGVTTMPYAVPAEEAEFEGVGGTAAGLGGWHLALNPNTDRTDEALAVLEAFTHDDVMLTIFELQGFLPPVLELVDEADPAEIGPVARYADEIRLAGDNAVPRPVTDVWPEQSALIYQEVNAAYRGVKTPADAMTDLSARLERSERDVEGQNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP43</accession>
    <name>A0A3N6LP43_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89847">
        <property type="protein sequence ID" value="RQG89847"/>
        <property type="gene ID" value="EA462_07470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019278">
        <property type="entry name" value="DICT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016954">
        <property type="entry name" value="Uncharacterised_Vng0742h"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10069">
        <property type="entry name" value="DICT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030471">
        <property type="entry name" value="STR_Vng0742h_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DICT" evidence="1">
        <location>
            <begin position="107"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="242" mass="27300" checksum="D44014F6C2D7E2E3" modified="2019-02-13" version="1">MNGLRDAIDEIEAHRKRLEVYTDDPRTAAELKRQFSTQNVDVEHRPTTILGDPGFVVIRTSGGEFRGALGLDQFAEILSPDIHPPWVLSDSPANTSVLFDFLENTLFGSYSRRQMLATSREIEERAVRIGDGRLYTGFQRERAALEQTAVYDRLANHKSLSVTVFVDGKWSKRSGDVTVVTDTDGEIGDYWFVIFDGAGVELQRCALLAEERKPGRYYGFWTYDPDLVSSLVGHLATKYDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPI1</accession>
    <name>A0A3N6LPI1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91378">
        <property type="protein sequence ID" value="RQG91378"/>
        <property type="gene ID" value="EA462_05230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="163" mass="17480" checksum="EAE08D5DC0BDFCD7" modified="2019-02-13" version="1">MGESPAIPPGRAGASEASDQPRSGEGAARRSSQTTGSPSSKRLLTDGGRVESEPSLIRYPPVKPPTISETGQGHRYVRCTRGDNDDTVYIHQLCAIAAGADPYDVFGKQYDVRHVVPTEWLGPDAKTAKGTPILNTTETVALAPIWARCSDRFGEIDRSEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPS6</accession>
    <name>A0A3N6LPS6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDPG_MGDP_dh_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91513">
        <property type="protein sequence ID" value="RQG91513"/>
        <property type="gene ID" value="EA462_06005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="81" mass="8604" checksum="3CBCCF98949A7EE9" modified="2019-02-13" version="1">MVVGIGYVRLLPACHFSAAGFNVVDFGIDEDRMADLRDGSSHVDDISDCDVARALEAGLEPTTDPTCHSRPTPSSSPSRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPW4</accession>
    <name>A0A3N6LPW4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide peptidase SppA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sppA</name>
        <name evidence="3" type="ORF">EA462_11215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88954">
        <property type="protein sequence ID" value="RQG88954"/>
        <property type="gene ID" value="EA462_11215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S49" evidence="2">
        <location>
            <begin position="140"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="330" mass="35421" checksum="9F4F19B3B9B7400C" modified="2019-02-13" version="1">MGSTTGIERLAVLGLATAAFAVIGVGLFVLYPETLADLLGVAFALVVILVGVRIAGSIAASLFPGYDVAEVAVEGPITRDGGGRFPSSPGSTPADDIVEQIDRADEDDNVRALLVKLNTPGGEVVPSDDIRLAAERFDGPTVAYTTDVCASGGYWIASGCDELWAREGSIVGSIGVIGSRVNASDLAEKVGLSYERFAAGEYKDAGTPLKELEEDERAYLQGLIDDYYETFVERVSDGRDLEPEFVRDTEARIYLGQTAHEMELVDELGTRRDLEGELAQRLERDEVTVEEFEPERPLMARVGMGARGIAYAFGAGLAGVISEDRFRLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRN8</accession>
    <name>A0A3N6LRN8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91087">
        <property type="protein sequence ID" value="RQG91087"/>
        <property type="gene ID" value="EA462_03540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="83" mass="8967" checksum="5B8482FC42406A86" modified="2019-02-13" version="1">MTSIRDLLADRVGVGETYRLTLTERDGTLVAVHPDDDSPMDVAVVEGLESITRRPPPQPVTVEILDRVVDGRVAGKIVDADAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRW2</accession>
    <name>A0A3N6LRW2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89934">
        <property type="protein sequence ID" value="RQG89934"/>
        <property type="gene ID" value="EA462_07955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="9489" checksum="3850D673F3A9C6DD" modified="2019-02-13" version="1">MTGSSKPTDRQSAETSVVRSGLRTVARLAVDLLAIALWVLFLTLLFLETAWPRWAFYGMMLIGVGVYVFVTAPWAQSRSTARREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRX8</accession>
    <name>A0A3N6LRX8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91217">
        <property type="protein sequence ID" value="RQG91217"/>
        <property type="gene ID" value="EA462_04295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="126" mass="14871" checksum="8BA2A3A3FF0E2403" modified="2019-02-13" version="1">MRETKRESATLRAEMTPSLDLVFDLLSNRRRRYALYCLYDQPDDAATIEDVTETVVSLETRDTGPEPRSEIDEQKRQIRTELQHVHLPKLENAGVLEHDQRSGTVRYWTQPTLEEWLEHARHKELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS01</accession>
    <name>A0A3N6LS01_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisC</name>
        <name evidence="7" type="ORF">EA462_08280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89994">
        <property type="protein sequence ID" value="RQG89994"/>
        <property type="gene ID" value="EA462_08280"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 5 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="6">
        <location>
            <begin position="31"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="377" mass="40665" checksum="4FAB6D3E073A6326" modified="2019-02-13" version="1">MQPRDLSDHVAYEAGRGIEEVARELGRDPTEFVKLASNENPHGPSPAAAVAIRETASSVSSYPKSAHADLVRAIADRFGVDDQQIWLANGGDGAIDYLHRATLEPGDAVLTPTPGFAYYGMSARFHHGDDRAYSLERADDFEQTAAGVLESFDGERIVWVTSPHNPTGTTMALAEIERLAEETPAETLVVVDEAYGEFADRDSAVALIEGRAGYDARDDVAVLRTFSKAYGLAGLRLGYAIVPEEWAEAYTRVNTPFAASELACRAGLAAIDDDEHVERTVETARNSRDAMCDRLDAHVWPSEGNFVLVDVGNATAVSEALRERGVIVRNCSSFGLPDCLRITCGTEEETELAIETTNDVLADRAAGTGTRLGVTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS89</accession>
    <name>A0A3N6LS89_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_00535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92753">
        <property type="protein sequence ID" value="RQG92753"/>
        <property type="gene ID" value="EA462_00535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG92753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="235" mass="26367" checksum="CAE3C5FD6654776A" modified="2019-02-13" version="1">MTDPNVRDAIMTATYEALCDLGYTELTAQDIADRTDKSKSLLFYHYDAKEDLIADFLEYLLELFDERIAATEVLSPVERLAAFVDWYLYGSNESEHQSFHTAMLELRAQAPYNDRYRRQLRKSDDRLRATLEEILEDGIDAGQFVEHDREGTAALVIAAIDGSRIRQLTLGRDEYLDTVRSAVVDGIFDELLAEGVAFPHPRAVGDRLDLEPRLESPDSTPTDAETPDETGGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSD3</accession>
    <name>A0A3N6LSD3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92823">
        <property type="protein sequence ID" value="RQG92823"/>
        <property type="gene ID" value="EA462_00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="81" mass="8980" checksum="313553C89EFED39D" modified="2019-02-13" version="1">MSDGPGRKPTVTDDDILDVFRSSSDPVLTTSEVASNFDITHRGVRDRLEKLEREGVLDSKKVGARGMVWWYPGHTSTSNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSF3</accession>
    <name>A0A3N6LSF3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GtrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_01140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92858">
        <property type="protein sequence ID" value="RQG92858"/>
        <property type="gene ID" value="EA462_01140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="24"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="148" mass="15953" checksum="085E5BC14C8360BE" modified="2019-02-13" version="1">MTESVLEAVQMRTRALLSPGRFTQFAGVGLAGATVDIVALAVLVELAGLGPVIAKAISWELSIVVIFVINERWTFSGFGSTGPRAVGRRFLRSNGVRFAGFLVTLSVLTALVYGFGVWYLAANVVGLAVGFVVNYTFESLLTWKVHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSN3</accession>
    <name>A0A3N6LSN3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92973">
        <property type="protein sequence ID" value="RQG92973"/>
        <property type="gene ID" value="EA462_01795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012041">
        <property type="entry name" value="Znf_CPxCG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42195">
        <property type="entry name" value="PTHR42195"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19769">
        <property type="entry name" value="CPxCG_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015877">
        <property type="entry name" value="UCP015877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="217" mass="24094" checksum="D97CB541FBD4B74D" modified="2019-02-13" version="1">MSEIPDRVPTACPSCSPDLETVHEVLTTGGGTITVRCSECAHVHKVQPEREREVTLDVVVSQEGESFAANVTTPEDETVSVGDEFILETDEVLSTVRVTSVELDQQRRRDEAAATDIETVWTREVDNVAVNVTVHPKDGSRDDSRGITVHVPGDYEFEVGAIESFGDDEFEIDAVVVRDATTGYHRDRYEERGDMVLAKDVKRVYAYDQTSSAWSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSQ0</accession>
    <name>A0A3N6LSQ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92993">
        <property type="protein sequence ID" value="RQG92993"/>
        <property type="gene ID" value="EA462_01920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="157"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="342" mass="35163" checksum="BB6E7FCC312A1D63" modified="2019-02-13" version="1">MDRRTAVFFALSSLLLGGTFVAAKAGLEYFPPLLFVALRFDVAAVVMVVYVVATSTRAELLPRSAGDVGSVLATGVLVIGLSNAFLFVGQQYATSAVASIVFSLNPVLTPMFAAVLLSNERLSARGAIGIALGLVGVSLVVSPDPATLLGGDAIGRTILFVGAVSGALGAVLIRRIETGLSSTVRIAWGLPLAAILSHGLSWSAGESAASIAWTTEALLALAYVSLFAGVLAYVAYFSLIDSAGATRANLVFYVVPVVSTVGGWALLDESVPPLAIVGFLTIFAGFAVLGSESIDVPGAVRTSSNRLSKAMSNGVSSRIRAEVSSPDDPVSSSEETRGYRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT93</accession>
    <name>A0A3N6LT93_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dolichol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93243">
        <property type="protein sequence ID" value="RQG93243"/>
        <property type="gene ID" value="EA462_03355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="196" mass="21524" checksum="C353D4A00504A5E8" modified="2019-02-13" version="1">MADELKRRLVHASGAGLVALYLLADHFEVGLTWQYFRYLMIVLSFGVIGLEILRLRVGLEWWLYEKLTREYEQDQFAGYGYYMVSMTAVVLVFQPAIALPAMLMLAIGDPISGAVSDDSLRRVKGPTVLVTMFVVSAALATPFLFHSPLAIVAAALGATIADGVKLQFGEFIVDDNLTIPIYAATLSFLALEFAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVF5</accession>
    <name>A0A3N6LVF5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92697">
        <property type="protein sequence ID" value="RQG92697"/>
        <property type="gene ID" value="EA462_00225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="190" mass="21469" checksum="8065942FEB64E306" modified="2019-02-13" version="1">MGHRALVAYRRADRLFDLRYSHWGGQNLSLAAEISAESPLANGAIGADVLGDSIARERILPDFLDPCVHEMLYFVVPDREYAVTAYRVCWLEWGDGRDQGRGAIVETAVDDDRDVRTWFLATKTTLADVVEMGALSRRAAQAYLESRICENDGIVYTYGDPLETDSEYTPRPDSWLEDDSQRCGRNDENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVJ3</accession>
    <name>A0A3N6LVJ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92757">
        <property type="protein sequence ID" value="RQG92757"/>
        <property type="gene ID" value="EA462_00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="114" mass="12290" checksum="8B1DDCAA7F695F6A" modified="2019-02-13" version="1">MNHTNPFEIGWLDPQLAPVLLAVIVLAAIGTTILFGCGIVAYSRRRTRRYLLITLVLGLLVARSLVGLGTVFGLVPMTVHHLVEHGADVTIAALVLYAVYRSGPTTTRSGSKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXZ1</accession>
    <name>A0A3N6LXZ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR01548 family HAD-type hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92694">
        <property type="protein sequence ID" value="RQG92694"/>
        <property type="gene ID" value="EA462_00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006438">
        <property type="entry name" value="HAD-SF_TIGR01548"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01548">
        <property type="entry name" value="HAD-SF-IA-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="290" mass="32133" checksum="F3ECEE4A3611AE43" modified="2019-02-13" version="1">MNADAVVLDVDGVLVDVADSYRRAILESIERVYDRTIRKEDIQQFKNAGGFNNDWLLTDAAALYVIATSEGYDESIDEYTDRIAAEGGGVAAAEAVVRDAIGARANQRVHDRWDREHLRDVFQQLYLGTDLYRTIEGGEPELQTRGFIHDEPVLLEESTRERLTERYDVGILTGRPENEAGIALEQVGLEATLPLDHRFTMDDWEEGKPHPKALTTLAERFDAHTVVFVGDTLDDVRTAANADEADPDRTYHGVGVLTGGLTGVDGRRTFDEDGASMVLESINELPGVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYC7</accession>
    <name>A0A3N6LYC7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92864">
        <property type="protein sequence ID" value="RQG92864"/>
        <property type="gene ID" value="EA462_01170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="40839" checksum="A8818732A8B6C0E8" modified="2019-02-13" version="1">MPSLLVYGTYGYTGRLIANEAVSRGVNSLTVAGRDGERLSTQAAALGVDGRVFDLETDDVAAHVREFDVLLNCAGPFVETADTLVDACIETGTDYLDITGEFPVFERLRQRDESARDAGVTLLPGVGFDVVPTDCLARYLSERLPSGDKLTLGIKGRGTPSSGTARTLAGLAGDGGVVRRNGRLVNVPAAFRSRRIDFGDGPEHAVTIPLGDVVTAPRSAGVESVEVYAAMPPWMARAMATADSLAGLLEIRPVERSLSWLLEAILDGPGDRELAEGTMTIWGEIRERDEPSRRVRARLRTPNVYALTAHTAVGAAERLLAGRSDGEESADRVPPGFQTPATAFGSEFILEFAGTDRELLETPRDSDDPDRTVPGSEADGGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYX0</accession>
    <name>A0A3N6LYX0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">tRNA uridine(34) 5-carboxymethylaminomethyl modification radical SAM/GNAT enzyme Elp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">EA462_14890</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86942">
        <property type="protein sequence ID" value="RQG86942"/>
        <property type="gene ID" value="EA462_14890"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="PTHR11135:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="81"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RQG86942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="553" mass="63068" checksum="604D9B6735E0A763" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ54</accession>
    <name>A0A3N6LZ54_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87042">
        <property type="protein sequence ID" value="RQG87042"/>
        <property type="gene ID" value="EA462_15490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="264" mass="29045" checksum="977D8E6A1EBD5579" modified="2019-02-13" version="1">MTNPPAVLNEKTLAATYDGGYHENSWEVVKQYRKAIKYASKHNAGSSATASALEIPRGRLRTWIDGDGKPDPVRGIETARDYGWLECSYEDSVFAGLNVLVANVFSGGSIAEQYYQPSFALNHRKEDSHVFDAFELAGIECEIIDDRGDHGDEVRPAEHGTVLGRTLSSLGAPVGSKSNHHLELPEYLGGAPETVRERFVYAYLENRAIKHDKKQTLTVREDRNRAYLNALADLIDDVAGGGVSLQERDIVISADASRLLGTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZE1</accession>
    <name>A0A3N6LZE1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87142">
        <property type="protein sequence ID" value="RQG87142"/>
        <property type="gene ID" value="EA462_15655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="477" mass="50675" checksum="6D188CDDA225F047" modified="2019-02-13" version="1">MTTGVIPPKLLQLAWPLVLGNLLQTFYNLADMFWVGRVGSDAVAAVSLMFPLSWLFVSTAMGLTAATIALVSQHVGAGDDRTADRVVGQTILLALAVSSALAAVGLYFRRPLLWLIGARDQVFVEALAYIEVIFLALPLTFLFFAFRSSLQGAGDTKTAMWLVLISAGINVVLDPFFILGWGPFPEMGTRGAAVATFIARAIAAVAGIVILLDGRFGVRLRVGDLVPNRAIQRRLIDVGYPATIDGWARSFASVAMAGFVARFGAAPTAAYGIGVRLMSVTWAVSGAVGDATATGVGQNLGAKTPERAATVARTATATTMVFIFAVAAILLAFPAQAMRIFVADPDVIAEGVVFLRIMTPFWALFAGVMVIQGAFRGAGNTREAMVLSFLSRWIFRVPVALVLAFAWTITVPGVGLTFAAFDWGIEGIWWAYSFGMVASFVVAVAWFRLGTWREAVIDDGSSPGDGSSPPETDTESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZF3</accession>
    <name>A0A3N6LZF3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-isopropylmalate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_02165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93304">
        <property type="protein sequence ID" value="RQG93304"/>
        <property type="gene ID" value="EA462_02165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="41489" checksum="D129AEFB45879AC4" modified="2019-02-13" version="1">MESARVFDTTLRDGEQSPGTSFSYDDKRQIASILDEMGTHVIEAGFPVNSDAEFEAVRDIASSTSTTTAGLARVVDGDIEAALDSGVEMVHIFVSTSDVQIEDSMHATREEVVRRSVESVERIKAAGATCMYSPMDATRTDEAYLIDVIEAVTEAGTDWINIPDTCGVATPGRFRALIEKVLNHTDARIDVHAHDDFGLATANALAGIEVGAEQAQVSVNSIGERAGNAAYEEFVMAVESLYQGDTGIDTTRITELSEVVAEKSGVPTPGNKPVVGDNAFSHESGIHAAGVIENSDTFEPGVMTPEMVGAERRLVMGKHTGTHSVRERLLEVGFDPTEEQVRAVTRRVKDYGAEKRRVTVSDLERFAEEAGVERQHEQEEVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZF9</accession>
    <name>A0A3N6LZF9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_02725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93314">
        <property type="protein sequence ID" value="RQG93314"/>
        <property type="gene ID" value="EA462_02725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="39"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="382"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="426"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG93314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="657" mass="73516" checksum="B74B6379914D83F7" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M059</accession>
    <name>A0A3N6M059_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NifU family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88980">
        <property type="protein sequence ID" value="RQG88980"/>
        <property type="gene ID" value="EA462_11360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="2">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="121" mass="12948" checksum="AF62160D906AF86F" modified="2019-02-13" version="1">MTESDADPSLRERVERWLGREMPIIQMHGGTSAVREADPDTGEVIIELGGGCSGCSVSDITTGNIEAELTTWPEIDEVTVRVPDPRESLGGPEQAESIMGVDRTEGGRGDWGSSNPGKDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0C1</accession>
    <name>A0A3N6M0C1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87984">
        <property type="protein sequence ID" value="RQG87984"/>
        <property type="gene ID" value="EA462_14090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="397" mass="42754" checksum="AD3F536C2C1B14D5" modified="2019-02-13" version="1">MDEMDFPTSDVKIESVTPTELKARIDAGEDVALLDSRMGSDYEEWRIDGPTVESINVPYFEFLDEEIDDDVLVRIPDDTEITVLCAKGGASEFVAGSLKECGYDVHHLEDGMNGWARIYEAVEVERYDGAGTLYQYQRPSSGCLGYLVVDDGEAAVIDPLRTFTERYFEDAEERGVDLKYAIDTHIHADHISGVRNLAAEGVDGVIPDAAVERGVTYADELTLASDGEVLQVGDVSIETVSTPGHTSGMTSYLVDGSLLATGDGLFVESVARPDLEGGDDGAPDAASHLYGSLQDRVLSLPDETLVGGAHFSDAAEPADDGTYTASIGQLRDEMAPLTMDEDEFVDVILSDMPPRPANYEDIIATNLGRKEVDDGDAFELELGPNNCAASQESLAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0H4</accession>
    <name>A0A3N6M0H4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_14485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88054">
        <property type="protein sequence ID" value="RQG88054"/>
        <property type="gene ID" value="EA462_14485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="30"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG88054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="389" mass="42405" checksum="CDF4C822C9050F0E" modified="2019-02-13" version="1">MNANGCADRIVRMPESGIREVFDKAAQYDDIADLSIGEPDFTTPEPIIDAVDERVRAGATHYTPTAGRSDLRESLSRKLARENDISVDPESEVLVTPGAMGALFESIHSLVDPGDEVVIPEPFWPNYHGHVASAGGTIVPVETDRKDGFVPSPDRIADAITADTKLLVLNTPSNPTGAVIPQATLERIASVVDEADIWCLVDETYESLVYDDREHYSIASDPALFDRTVTVHSFSKAYAMTGWRVGYVSGPSHIIDSIRVLQEHTVSSVAEPAQVAAMAALESPELLEEIRETFDRRRTLMVDRLGSVPGLSPVDPAGAFYVFAELTGTELDSRSVVMRLLEDEQVAVVPGSVFGESAESFLRLSYATNEATIEDGTDRMRRVFESFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0L5</accession>
    <name>A0A3N6M0L5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88104">
        <property type="protein sequence ID" value="RQG88104"/>
        <property type="gene ID" value="EA462_14250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="77" mass="9270" checksum="9BC7912FF651F463" modified="2019-02-13" version="1">MDPYPTERLYEEIAFVAYYFNWSRQEILELPHWERQRWCRNISQINEQKNEAGGSDTSLDPDHRVDDLPVANLEEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1F5</accession>
    <name>A0A3N6M1F5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:solute symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_11035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88921">
        <property type="protein sequence ID" value="RQG88921"/>
        <property type="gene ID" value="EA462_11035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG88921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="515" mass="55285" checksum="5DD8D42043379AED" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1Q8</accession>
    <name>A0A3N6M1Q8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89021">
        <property type="protein sequence ID" value="RQG89021"/>
        <property type="gene ID" value="EA462_11605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="370" mass="39897" checksum="F1DBC7428E173222" modified="2019-02-13" version="1">MGSSSWSRLGDLFRPPIHPLEVQGGCFSGLCVVNRSSSNTGVAVQPKCMMRTVRAVIPSVTALVWNEAQGRVRAPWRILAPLLPMFGVGIVVSTLLFGRVSVPVLITATQMTLAIAMVTAVAVTTRYLDRGRTVWQYGLRADRRWAHDLLAGFGLAAGAVAIPYLIGVAIGWYEISTTFAAGHVSFWMGLLLVVIAYLGTGVWEEVFFRAVFMVNAAEGLRRWLSPKHTLVVVLAVQTVIFGVIHLEHWSVQAPHPAFVVTWILAGLVYGVLYLLSNDLALPIAAHAGGNAAGASLISATDPADSGWGVLVLVEPTSEAILLGHGGVMMFSANVLVLSFGIGWLRYTRKGPLELWDHPAFFVTEQIGESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2A0</accession>
    <name>A0A3N6M2A0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxybutyryl-CoA dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.157</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_07935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.157" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89930">
        <property type="protein sequence ID" value="RQG89930"/>
        <property type="gene ID" value="EA462_07935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="9"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="188"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="284" mass="30956" checksum="FD855F65C39E1F40" modified="2019-02-13" version="1">MLRTEIDRIGVVGAGTMGSGIAQVGATHSYNVVMRDLEPELIEDGIATVESSLERLESREDLEESSDRIRDRIEGTTAIDALADCDLVVEAAVESLSIKREIFADLEGVCGEDVLLATNTSTLSITSIASVLDRPERVVGIHFMNPVPIMDGVEIVVGEKTTDEVTELAHEVARTLGKTTWESDDKPGFVTNRILMPWINEGIRVFDEGVATRDDIDAGMELGTNVPMGPLSLADHIGLDICLHASETLYEELGERFKPAYLLKRKVEAGDLGKKTGTGFYDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3S1</accession>
    <name>A0A3N6M3S1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89861">
        <property type="protein sequence ID" value="RQG89861"/>
        <property type="gene ID" value="EA462_07550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="71" mass="8083" checksum="B3DBAFC03931657E" modified="2019-02-13" version="1">MITCTNCETPQFLQITQSRVYFENGEMINEISESYECTLCGSTGQYVYDDEHNEEGVSGDVELTTERPKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4K0</accession>
    <name>A0A3N6M4K0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90161">
        <property type="protein sequence ID" value="RQG90161"/>
        <property type="gene ID" value="EA462_09235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="90" mass="9869" checksum="EEEF93BA3A70DCF7" modified="2019-02-13" version="1">MTREHLAEAATSIQSASDAADDDETIERLRNQSEQFSTLADADRGPDHGKLARHEHVLTEIADGESSDVASHVERALESIHAYRETLEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6B5</accession>
    <name>A0A3N6M6B5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="11" type="ORF">EA462_06515</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004213785.1">
        <property type="nucleotide sequence ID" value="NZ_REFY01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91600">
        <property type="protein sequence ID" value="RQG91600"/>
        <property type="gene ID" value="EA462_06515"/>
    </dbReference>
    <dbReference type="GeneID" id="8823129"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="10">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="233"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG91600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="320" mass="36498" checksum="3D171BFA25B71FE5" modified="2019-02-13" version="1">MTRSTRQRERTREKDETEDQEGVRACPECESDNLVKDSDRGELICEDCGLVVEEEKIDPGPEWRAFNHQERQEKSRVGAPTTQTMHDKGLTTTIDWKDKDAYGRSISSKKRSQMHRLRKWQERIRTKDAGERNLQFALSEIDRMASALGVPRSVREVASVIYRRALKEDLIRGRSIEGVATSALYAACRKEGIPRSLEEISEVSRVERKEIGRTYRYISQELGLEMRPVDPKKYVPRFCSELELSEEVQTKANEIIEKTAEEGLLSGKSPTGYAAAAIYAASLLCNEKKTQREVADVAQVTEVTIRNRYQEQIEAMGIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6D8</accession>
    <name>A0A3N6M6D8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88866">
        <property type="protein sequence ID" value="RQG88866"/>
        <property type="gene ID" value="EA462_10730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="43"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="309" mass="33219" checksum="287940871D9B5F10" modified="2019-02-13" version="1">MEIQRREFIAAIGSSAAVGLAGCAALGGDDGDGPEISGETLTLTTTTSTYDTGLLDELNAPFEDRYGVTVDTVSQGTGAAIETGRSGDSDVVMVHARSQEDEFMEDGYAINRRDLMFNDFIIIGDPDDPAGISGSDDAVEAFAQIAESESAFVSRGDNSGTHTQELEIWEEAGFEGGEFGEWYQEAGQGMGEVIVQTGQSGGYTLSDRGTYLSMINDTDLEIHVEGPVEDGPEILSNPYGIFAINPGVHDNVNYDLAMAYIGFITSLEGQEIIEEYTVEGEQLFFPEAIAEEPNFQQYVPEDWDGSNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8B9</accession>
    <name>A0A3N6M8B9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91621">
        <property type="protein sequence ID" value="RQG91621"/>
        <property type="gene ID" value="EA462_06635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="132" mass="15458" checksum="A06F8DE29C1E3BB1" modified="2019-02-13" version="1">MDEVVLIRTMLDNHYQSSEYEIRFEDHEERRPELSPGDVFRLLADDHRRYAVQYFATRTSTVATVDDLATFVDDHADDADRRTIEIELVHTHLPKLAASDVILYDSSTKRVRYVGETFLETCLDWASDRDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8V4</accession>
    <name>A0A3N6M8V4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAA hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92680">
        <property type="protein sequence ID" value="RQG92680"/>
        <property type="gene ID" value="EA462_00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="295" mass="32048" checksum="BA1EAC405934DD65" modified="2019-02-13" version="1">MRLGQYTTTDDAQPWVGVTTADGEIVNLSETGAETGIAIPRATSDLLGQWNWQRKVELVVEYAEETGIGCYDAPELDQYAPVHDPEKVVCVGLNYRDHAEEGGNPIPDEPVLFSKFPTSVTGPESTITWDPDLTQKVDYEAELVVVIGEETRRVDEDEALDHVAGYTIGNDVSARDLQHGDGQWVRGKSLDSFAPTGPELVTADAVDAPHDLDIYAEVNGQRLQDSSTSNFIFGVDELVSFCSQAFTLEPGDLIFTGTPPGVGVYREPPVLLEERDEVTVGIGELGELTNGCAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8Z5</accession>
    <name>A0A3N6M8Z5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89956">
        <property type="protein sequence ID" value="RQG89956"/>
        <property type="gene ID" value="EA462_08080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="68"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="222" mass="24502" checksum="C7E5BE3AD54C39D9" modified="2019-02-13" version="1">MSPDDHSGREDGEEQPLEGEEAVVDEEEEMVVDDDEGIAVEADRVRNAAAEEVDQRIVDLLSWILDTETRAKIYVHLLANPGSTSEEVAKGTGLYPSTVREALAELHDEERVTREKRASEGAGNNPFEYTAIQPSELVGGVVDQVQRELNTIFTLDRVLDRNERSDPAIEGDVEPVTITVDEIDPFGDDAHPSRVDESADDGQEDDGRTDIEISEPDDDTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M932</accession>
    <name>A0A3N6M932_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rnz</name>
        <name evidence="10" type="ORF">EA462_00635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92770">
        <property type="protein sequence ID" value="RQG92770"/>
        <property type="gene ID" value="EA462_00635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="33"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG92770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="309" mass="33459" checksum="9E12D8AED91244E9" modified="2019-02-13" version="1">MPLRVTFLGTAGAVPTTDRNPSGIFVARDGEGLLFDAGEGTQRQMMRFGTGFSISNLFVTHLHGDHVLGIPGLLQTMAFNDRERPLSIYTPDGTRQQLRELIGALGTRLSFPLHVTAVEDGDVAHRGDDYEVRAFETDHDTRSVGYALVEDDRKGRFDRERAEDLGVPVGPKFSTLHEGNPVELEDGTVVEPEQIVGDPRPGRTIVYTGDTRPTAATVEAAADSDLLIHDATFAEDGADRAAKTAHSTAREAAEVASRAGVERLALVHLSSRYAGYPDGHLAEAREVFDGTALVPDDGDELEIPYPNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M946</accession>
    <name>A0A3N6M946_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0215 protein EA462_00745</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0215 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92790">
        <property type="protein sequence ID" value="RQG92790"/>
        <property type="gene ID" value="EA462_00745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00582">
        <property type="entry name" value="UPF0215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002802">
        <property type="entry name" value="DUF99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518">
        <property type="entry name" value="PTHR39518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01949">
        <property type="entry name" value="DUF99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="191" mass="20425" checksum="8450E4BDCEDB07ED" modified="2019-02-13" version="1">MKSGVRALGIAESYRGDRCPDRTRSTLAGAVVRADSVLDGLTYGQCTVGGTDATEAVVSVVEDLDRPDVRYVLLGAIAPAWYNVLEPSRIAATVQRPVITVSFEASDGLESGLDEAFSDTDLEHRLEIYRSLPERRTLSINGETVYVRHVGCGADEAAEVVDAFTPSGGRPEPIRVARLAARAGDAYAEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M972</accession>
    <name>A0A3N6M972_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90046">
        <property type="protein sequence ID" value="RQG90046"/>
        <property type="gene ID" value="EA462_08580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="1">
        <location>
            <begin position="38"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="566" mass="63263" checksum="ABA389D68DBF901B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9A4</accession>
    <name>A0A3N6M9A4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anthranilate synthase</fullName>
            <ecNumber evidence="4">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_01150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92860">
        <property type="protein sequence ID" value="RQG92860"/>
        <property type="gene ID" value="EA462_01150"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="10">
        <location>
            <begin position="46"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="9">
        <location>
            <begin position="262"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="530"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG92860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="564" mass="61498" checksum="F722B62A6103B93A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9A7</accession>
    <name>A0A3N6M9A7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03557 family F420-dependent LLM class oxidoreductase</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90096">
        <property type="protein sequence ID" value="RQG90096"/>
        <property type="gene ID" value="EA462_08845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="318" mass="34958" checksum="3A7BB79EFA54AFBC" modified="2019-02-13" version="1">MTQLGYTLSSEEHGPMELVENARRAEAAGFDFVSISDHFHPWISAQGESPFVWSTLGAIAAATDEIDVGVGVTCPTMRIHPLNVAHAVATVDEMLDDRFTFGVGTGENLNEHVVGHRWPEHDVRLEMLEEAMAVMRSLWTGETISHRGEYYTVENARLYTVPDDQPTTIASAFGPRTAEWAAEYGDGIWCSGPQTEIVDIYEDAGGEGPRYTQVHCCYAETEAEAIDTVLKYWPNGSLPGELAQELPTPAHFEQAASMVDREDVGASGTITDPDPTAHVEGIQEAIDAGYDHVYVHQIGPDQAELLEFYEEDVLPSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9J2</accession>
    <name>A0A3N6M9J2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="8">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpA</name>
        <name evidence="11" type="ORF">EA462_09415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90196">
        <property type="protein sequence ID" value="RQG90196"/>
        <property type="gene ID" value="EA462_09415"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG90196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="301" mass="31231" checksum="7CDFB17266510C1A" modified="2019-02-13" version="1">MSDDRDDSSDRPAVDSEIEAAIYENHPALIAYITAGDPSLEDTKAYVEALDRGGADLIELGLPFSEPIAEGPTIQGAINRALAAGTTPAGFFDLVDGLETDAPLLVMTYYNMLLQFGAEADVRPFVERAADAGISGVIVPDLPAEEAEPLCAACDEFGLDVVFIVAPTTEGDRLETIMSRASGFVYVQARLGTTGARADVSSATHDSLERLEGHSDVPKAVGFGVSKGDHAAEIVEAGADGVIVGSALVDIVAAHGSDGDAPAAADLEEKARELKAGAERAAADADATDGEQERTPEPEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9W8</accession>
    <name>A0A3N6M9W8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CocE/NonD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93110">
        <property type="protein sequence ID" value="RQG93110"/>
        <property type="gene ID" value="EA462_02585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="326"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="629" mass="71472" checksum="350C142707B6A515" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MB32</accession>
    <name>A0A3N6MB32_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Elongation factor 2</fullName>
            <shortName evidence="7">EF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fusA</name>
        <name evidence="9" type="ORF">EA462_00020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92661">
        <property type="protein sequence ID" value="RQG92661"/>
        <property type="gene ID" value="EA462_00020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_A">
        <property type="entry name" value="EF_G_EF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004543">
        <property type="entry name" value="Transl_elong_EFG/EF2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00490">
        <property type="entry name" value="aEF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="19"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Diphthamide" evidence="7">
        <location>
            <position position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG92661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="728" mass="80669" checksum="1AE9BE0D5C62BFD7" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBQ5</accession>
    <name>A0A3N6MBQ5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="7" type="ORF">EA462_01380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92901">
        <property type="protein sequence ID" value="RQG92901"/>
        <property type="gene ID" value="EA462_01380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="328" mass="36301" checksum="0049B10ED4342C4E" modified="2019-02-13" version="1">MSEEPADEGDAENPDASREAPEERPPSDEESSSASTDDPPGSDDDDPPLETDGEGVVGSGHDHDSGESSYPEPEYPDPDEDVGGISTPPDDEEMPLADHIEEMILRLAVVLLVGSAGTAIGLLWASQAIEHVWLNVFPYEIDQVPPPHVYHPLELWLTRIKFSALLGIMLALPVFVYQCYLFMKPGLYPNERKYYLAAVPTSVVLASVGMLFSYVLVLPVLFEYFTFYAEGSADIAYALGDTFDLIITLTGFLAIVFQIPLFIMLAIMMGVTTRRWLAEKRLYFWAAFAGLSFMFTMDPTMMAPVLVAITMILLFEGTLLILKWVGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCB2</accession>
    <name>A0A3N6MCB2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent glucose-6-phosphate dehydrogenase</fullName>
            <shortName evidence="1">Glc6PDH</shortName>
            <ecNumber evidence="1">1.1.1.388</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:38215"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.388"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.388" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93131">
        <property type="protein sequence ID" value="RQG93131"/>
        <property type="gene ID" value="EA462_02700"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02046">
        <property type="entry name" value="Glc6PDH_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032884">
        <property type="entry name" value="Glc6PDH_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="247" mass="27368" checksum="EBEBF37A50A5E182" modified="2019-02-13" version="1">MAQSVLLTGAAGRVGDAILGDLADEHEWRLVDRDPPTGEQPGEFVVADITDGDAVRAAMDGIDVVIHLAGDPRPEAPWDSVLTNNIDGTQTVFEAAVDAGVEKVAFASSNHAVGAYETDDRTPDMYRTHDDYLLDGTELPRPGNLYGVSKAAGETLGRYYHDERGLSVVCIRIGNLTEDHPPIDYERGQAMWLSYRDCAHLFDRCIRAEYGYEIVYGISDNDRKYYSIDRARDVLDYQPRDNSAEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFV0</accession>
    <name>A0A3N6MFV0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">16S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_00775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92796">
        <property type="protein sequence ID" value="RQG92796"/>
        <property type="gene ID" value="EA462_00775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:18S rRNA aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="PTHR20426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RLI" evidence="9">
        <location>
            <begin position="3"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Ribo_biogen_C" evidence="8">
        <location>
            <begin position="40"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG92796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="167" mass="18869" checksum="F5A6F961CD999520" modified="2019-02-13" version="1">MECHVYYEGDDDPEKCTARRMEKFDEAILYRTMGQVPYGVVLNPHAERALSPADREAGLDTLVALDCSWESAEAASFRMNGVHRALPFLVAANPVNYGRPFRLTTVEALAGALCIFDELEHAESILEPFRWGETFLTLNEEPLRRYSECTDSSEVVAVQEEYLADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MG92</accession>
    <name>A0A3N6MG92_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_01695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92956">
        <property type="protein sequence ID" value="RQG92956"/>
        <property type="gene ID" value="EA462_01695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="388" mass="40324" checksum="A2C9FB5DDAB1BD90" modified="2019-02-13" version="1">MVETLLLVGVVASVFVGFNIGGSSTGIAWGPAVGAGLLRKTTAAGLMTFFVFLGGWTVGRNVMETLSEGIIHIEISLAAGVAVLFFIGMGILVANVFGVPVPTSMTTVGAIAGLGLATDTLNFETIGWIVSWWVVTPIIGFWVGATIGRYVYPELNRRFEITSTEGPLLVFSPAGSRLPIGFGPNTTTQELAGTIVVFVIGCYMAFSAGASNVPNAVAPLVSSDALEPNTAIIVATIAIGLGGFTIARRTMESVGSELSDIPLLAALIVMITASTITTTLSWMGIPISLVMSSVMTIVGLGWGRATRPITAREAIRGSSDAEIAMGALTAEPEAPVTEIGAEESESALDAGDLFNPRAVIKYVSMWIIGPSMSTLLAYGFFSIFPFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGG3</accession>
    <name>A0A3N6MGG3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93036">
        <property type="protein sequence ID" value="RQG93036"/>
        <property type="gene ID" value="EA462_02145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="98" mass="10590" checksum="FF6AC0D60622B68F" modified="2019-02-13" version="1">MTRTTEPNSDDGETMADVSHANPYTGRATGQLFTRGPIVAADGGERVDDDRPASTDSADTTEEERGRTMASVDHTPPKKADDANRVFERGHDRAGENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MR57</accession>
    <name>A0A3N6MR57_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86723">
        <property type="protein sequence ID" value="RQG86723"/>
        <property type="gene ID" value="EA462_16435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="129"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="320"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="592" mass="64817" checksum="3F431D5B6A3E81E2" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MS46</accession>
    <name>A0A3N6MS46_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87043">
        <property type="protein sequence ID" value="RQG87043"/>
        <property type="gene ID" value="EA462_15495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="79" mass="8838" checksum="4AFD2AC1FAB1272B" modified="2019-02-13" version="1">MTQADDRVLETLSDSGLILSPRILSANTDYSRHYLSTRLGHLLDAGLVERVDEGLYKITDRGQAYLEGDLEAADLERDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MU73</accession>
    <name>A0A3N6MU73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88942">
        <property type="protein sequence ID" value="RQG88942"/>
        <property type="gene ID" value="EA462_11155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="2">
        <location>
            <begin position="73"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="135" mass="14842" checksum="BA5B49995DCECD8F" modified="2019-02-13" version="1">MEISEKLLCLFSTEVSAEEDRYVIEVPRQEIETGDVDPGEVYRVALISRNEESADGETTATQPQSAPSEPQPPVDVGETRYVEIEDIGKQGDGIARVERGYVIIVPGAEVGERVKIEVSEVKSNFAVGEIIEETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MX61</accession>
    <name>A0A3N6MX61_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90082">
        <property type="protein sequence ID" value="RQG90082"/>
        <property type="gene ID" value="EA462_08770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="50"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="217" mass="24400" checksum="CABD3A23F1756645" modified="2019-02-13" version="1">MSERSTQETPRDDREISHPVFAAIYDRVPQSWLLRSHREYLTRALSGRVLEIGAGDGAMFPYAAAAGTDIEYHAIEPDPHMRTRAESAARERGFPVDLRSARAESLPYPDESVDVVLASLVFCTIEDPDAALAEAARVLKPGGEFRFLEHVRADGWRGSGQDLLNPLWKRAAGGCQLNRETIPRFVSHDAFSVVEIERLRFGIFPVRPFVRGTLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXE7</accession>
    <name>A0A3N6MXE7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90182">
        <property type="protein sequence ID" value="RQG90182"/>
        <property type="gene ID" value="EA462_09340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="76" mass="8912" checksum="BCBB8D89D089A849" modified="2019-02-13" version="1">MRFFHHTSIVRFDDIELLSLPSVDRSKNRTHEIDYSDSVNRQHLRTLRFRGRSGRGLQTVVRPSETNEAATGSHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXI7</accession>
    <name>A0A3N6MXI7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90222">
        <property type="protein sequence ID" value="RQG90222"/>
        <property type="gene ID" value="EA462_09565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="74" mass="8530" checksum="2CAC77BA43A4594A" modified="2019-02-13" version="1">MTDYSDEEQRILSYLRENAARGERYFRAKNIAKSIGLSSKQVGVRLPHLAEKSDDVDIEKWGRARSTTWKVTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0Z8</accession>
    <name>A0A3N6N0Z8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CARDB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91612">
        <property type="protein sequence ID" value="RQG91612"/>
        <property type="gene ID" value="EA462_06585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARDB" evidence="2">
        <location>
            <begin position="476"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="781" mass="84817" checksum="1E34211916C87EDF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3Q5</accession>
    <name>A0A3N6N3Q5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92772">
        <property type="protein sequence ID" value="RQG92772"/>
        <property type="gene ID" value="EA462_00645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="6933" checksum="EAF32C2C20692264" modified="2019-02-13" version="1">MVRSLLSRLRDWIAVEDADERLEGSGEAITSPQHRRSPEAERTLEEAKKRADERRNEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3R1</accession>
    <name>A0A3N6N3R1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92782">
        <property type="protein sequence ID" value="RQG92782"/>
        <property type="gene ID" value="EA462_00695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="6533" checksum="A46080E13834B3A9" modified="2019-02-13" version="1">MQTAAVLNVIVDNIVEMNELFTDVAMGEGLAPLLVLVGTLLIVFSVGVFGALTLGAIGSLVTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3U6</accession>
    <name>A0A3N6N3U6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92822">
        <property type="protein sequence ID" value="RQG92822"/>
        <property type="gene ID" value="EA462_00925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="685" mass="74883" checksum="0D4C7BD52F192054" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4V9</accession>
    <name>A0A3N6N4V9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF892 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93232">
        <property type="protein sequence ID" value="RQG93232"/>
        <property type="gene ID" value="EA462_03290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF892" evidence="1">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="160" mass="18268" checksum="F889AA08EB3C0FE9" modified="2019-02-13" version="1">MTTTTPTEMFERELQKLYHAELEILDLHADLAEAAASEDVEVLFTDHEEDTVEQIHRIERLFEELDQEPRAEGSPVMEGILAEKNEIVSTDVPPALRDLDVLSTGMMNERFEITVLDRLLLLAADIELPEEITKELAANRQEARAALTKMEAIVERRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NTY5</accession>
    <name>A0A3N6NTY5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86146">
        <property type="protein sequence ID" value="RQG86146"/>
        <property type="gene ID" value="EA462_16880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="86" mass="8886" checksum="ECC05E30AEB1A3D3" modified="2019-02-13" version="1">MTSTATNSSENTGLLKTRFSIGAAGLAAISVLVALLFAWTGYRGDELLIVGTEMDVVTGMAGAMMALFIAVVALIAAAYMEPGFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVK9</accession>
    <name>A0A3N6NVK9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87882">
        <property type="protein sequence ID" value="RQG87882"/>
        <property type="gene ID" value="EA462_13545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="234" mass="25610" checksum="7003F3295381E79B" modified="2019-02-13" version="1">MTSQSDTVIVAIVLANTDGRPWVIRLDSADGTIIRGRHGIDAMISDPALVLIDVQAQFCDPEYGYIPEAEAETIEERIESANELVGRYRESGRQPIFVRVVHDERATSPVWSDKYGDGPLPCAPGSDGAAFDSALDVREDDAIVTKHRYDAFHETDLEVYLSSNDVSRLLVGGIATEVCVESTVRSAFDRDYRTTVLSDCTASADPVARERSLERIDAKFGEVKPSTEVSLGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVQ6</accession>
    <name>A0A3N6NVQ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF120 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_13905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87952">
        <property type="protein sequence ID" value="RQG87952"/>
        <property type="gene ID" value="EA462_13905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP-dep_RFKase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="311" mass="33406" checksum="6C4063F2ADC702B0" modified="2019-02-13" version="1">MNGRVTSGEGQARGFIEAASELLTDALGFRPYPGTLNLENAGRLESLSAERHPIPGDDHCEGIVTRSCRIGGLRGAVVEPIVPNYPDEKTELVAPVRIRSVFDLADGSEVDLTAADRCDGAWNPTIDGRSIDAFDGVVFDLDKTLLTLDVDWPAVHRDVEALLESVLEKPLPTYTRLEVFELAAKAGRSDELESLLADRERAGARTANSRPLLDVVADLDCPVGICTANAERAAEIALERFGALGDVDAIVGRDTLAQDKPHPRTLLEVVRTLNVAPGNVLYVGDEETDAELAVAAETSYAHPDQFRGDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWK5</accession>
    <name>A0A3N6NWK5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88929">
        <property type="protein sequence ID" value="RQG88929"/>
        <property type="gene ID" value="EA462_11080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="347" mass="36778" checksum="51DB6C2EACE8911A" modified="2019-02-13" version="1">MPQWTAFVAITCVVLALLLVLSYLTQSTLSDPQSPDSGREDNSEGVLESTGSPLNRAESEAVRSGSSASETATPRQRDSETETPGEKPDSTPEANSRSTPEADVERPLERRRDDTAPERKSDETTLETETAEPIPAEMANEIDPESLSTGAMLANVALSQGLFAFVLIGAILYTGIPADALGLEFSRSYLEAGLVLGVAAGVVLYVANELGAAIATRFGFDHDERLRALLAPDSGGGWLVLLAVVLPIIALFEELLFRAALIGVVAAGFGISPWLLAVLSSIAFAVGHGMQGSVGIVVTGLLGFVLAGIFILTESLLVVVVAHYLINALEFVVHEGFEFEWAKPLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWU3</accession>
    <name>A0A3N6NWU3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF373 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89049">
        <property type="protein sequence ID" value="RQG89049"/>
        <property type="gene ID" value="EA462_11760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007254">
        <property type="entry name" value="DUF373"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815">
        <property type="entry name" value="PTHR38815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04123">
        <property type="entry name" value="DUF373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="371" mass="39450" checksum="7A36971DA1AC1DD6" modified="2019-02-13" version="1">MLLVLCVDLDDDLGRKTGFSTPVIGRAPVEEAAVALATADPEDSDVNVIFQGLHVYDDLTERDESVEVAVVTGNDEGDVDANREVGDEVDTVLASLSTAEDVTALVITDGAQDESVIPIIRSRVPIDGVRRVVVRQAQNLESMYYTIKQVLDDPETRGTILIPLGILLLIYPLALIGSALERPGFVLGATSALLGFYLISRGLRLGDRLDAAVERGRRSLYAGRTTILAYVVAAVLVVLGIVSGLNELEAVRETTATEVGALASVAAFGYGSIQWIAAAAVTTSLGQITDEYIADSLEWRYLNAPFYVLSIAIVLQAVSAFFLDRVGTTYLAMALTAGTLLGIVSTLTFAVAESRLSDSGDSGETHDPKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX19</accession>
    <name>A0A3N6NX19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S26 family signal peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89169">
        <property type="protein sequence ID" value="RQG89169"/>
        <property type="gene ID" value="EA462_12440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="379" mass="40862" checksum="E293E96081C194E4" modified="2019-02-13" version="1">MKVSDLGQYTLALLIVLMIVLLLFGQLLGQPFIVFVETGSMEPTLEPNDGFIAIPALFAGEIEEGDVVLFDAQELGGGELTTHRVEEVTDEGYLTKGDANPFIDQDGDEPPVAEGQVRSVAVQMNGNMVVIPGLGASVTSITTTVESVQDRVFSPFGIDPPDIGTFSTGVLVLGLVLYIVSTIRATGDKRARDRSEGSLLQNAVLIIVILTLVVIIPVNFSMLLPSGTYQYEIVSSTDPTSDEQVIGVGESSEVTYFMQNSGHLPVVTILEPASDGVDVPEGYTYVPRVSAENVSVTMHAPEETGVHFRFVREYRYLVVLPPSLIATLHAIHPVVALAAINVTVAAVVVTVSVATIGTNRIRTRSKGRELTIWEQLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX68</accession>
    <name>A0A3N6NX68_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative asparagine synthetase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_12755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89229">
        <property type="protein sequence ID" value="RQG89229"/>
        <property type="gene ID" value="EA462_12755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="629" mass="70618" checksum="F5654828D0B858E0" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYX4</accession>
    <name>A0A3N6NYX4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90079">
        <property type="protein sequence ID" value="RQG90079"/>
        <property type="gene ID" value="EA462_08755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="92" mass="9886" checksum="59130EB172892F69" modified="2019-02-13" version="1">MSEPDREPTEKPTTDREEAEREGRWMARNWIAIAVVSILAALLLAVGLLQATGLVDLFAPVVGTEGQQWGVFAILAVVVIAIAGWSWSAIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZC0</accession>
    <name>A0A3N6NZC0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90279">
        <property type="protein sequence ID" value="RQG90279"/>
        <property type="gene ID" value="EA462_09885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="74" mass="7997" checksum="583D3DBFE10FCA08" modified="2019-02-13" version="1">MNSSVAAEIEISIPQEISSAQAKLVYYYLATNGGGTVDDLHDELDISKGTALSITGTLRDQGHVERIDGRYELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P066</accession>
    <name>A0A3N6P066_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87788">
        <property type="protein sequence ID" value="RQG87788"/>
        <property type="gene ID" value="EA462_13015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="139"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="366" mass="40336" checksum="0CC16650C6268659" modified="2019-02-13" version="1">MTLKIGFLGYGMMARAHAHALNRLPLFFPEAPETDRTIIAGRDPDGVSNAADRLGFDRSTTDWREVVPAVDVLYVLTPPTVHREPTVEALESGVHVLCEKPLSTSVSAGERMVETAADSDAVVGCGFNYRFLPAIQLLKQFVEEGELGTIRHVRGQFLQNWQADATDAWTWRNDAEIAGAGRVADAGSHSFDLARWLVGPIDSVSGQLTTTIDNRPVDGTDERRTVSTDDAYGVLARFDSGARAIFDGSRVATGHTNTNTIELVGSRGTARFHCERLNELEVCLEGDRGFRTISVTDPEDPYVDRWWPPGHGLGWEHSVVHENYEFLSAIRDDGTFEPDFETGLAVARIVDAVRRSDETGRRVAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1G1</accession>
    <name>A0A3N6P1G1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl3</name>
        <name evidence="8" type="ORF">EA462_05025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91339">
        <property type="protein sequence ID" value="RQG91339"/>
        <property type="gene ID" value="EA462_05025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_A">
        <property type="entry name" value="Ribosomal_L3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019928">
        <property type="entry name" value="Ribosomal_L3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="PTHR11363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03626">
        <property type="entry name" value="L3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="340" mass="37315" checksum="9CD89BEAA1019045" modified="2019-02-13" version="1">MPQPNAPRKGSLGFGPRQRATSEVPRFNSWPDDDGQPTLQGFAGYKAGMTHVVMVDDKANSSTEGMEQTVPVTIVETPPMRAVALRAYENTPYGMKPVTEVWTDEFTPELDRVLDLPGDDYDTDAAADELRGLLEEGRVDDVRVITHTVPGDIPSVPKKKPDVMETRVGGGSADERLEYALELLDEDGGEHVMNDVFRAGEYVDASGVTKGKGTQGPVKRWGVQKRKGKHARQGWRRRIGNLGPWNPSRVRSTVPQQGQTGYHQRTELNKRLVDIGDGADATVDGGFVNYGEVDGPHALIKGSLPGPQRRLVRFRPAIRPGDQPRLDPEVRYVSTASNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1Y1</accession>
    <name>A0A3N6P1Y1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heme-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_12190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89125">
        <property type="protein sequence ID" value="RQG89125"/>
        <property type="gene ID" value="EA462_12190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="5">
        <location>
            <begin position="423"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="513" mass="57155" checksum="EBE2ED93ED804026" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P203</accession>
    <name>A0A3N6P203_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable porphobilinogen deaminase</fullName>
            <ecNumber evidence="3">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hemC</name>
        <name evidence="10" type="ORF">EA462_12360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89155">
        <property type="protein sequence ID" value="RQG89155"/>
        <property type="gene ID" value="EA462_12360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="8">
        <location>
            <begin position="7"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deam" evidence="8">
        <location>
            <begin position="214"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="9">
        <location>
            <begin position="281"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG89155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="375" mass="41131" checksum="4F8A6F7F244657BC" modified="2019-02-13" version="1">MRTRGTLRLATRGSDLARRQASLVKSALEDRRYEVELVTVETTGDQIRDELIHRLGKTGAFVRELDEHVLEGDLDAAVHSMKDMPTEQPTKLVTAAVPERGTPGDALVTPDGTTLEELPEGSVVGTSSLRRRAQLLSERPDLTIEPLRGNVDTRLEKLLAPALQAEHQRRSEADSERKASTGDEEFEPEFDRTVDEWFDDLPELEKQALGREVETEYDAIVLAEAGLERSGVTHAVDYQRLPTNSFVPAPGQGALAVTAVDSETAREIQSAIDHPRSRVETTVERTLLAELGGGCIAPIGVYAVVQGEYAHTRVSVFDRDGEESVAATRDLPVETYAEAAREFADDLSERGAAALIERAREDSETPAEEDRPDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P2A8</accession>
    <name>A0A3N6P2A8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89285">
        <property type="protein sequence ID" value="RQG89285"/>
        <property type="gene ID" value="EA462_11900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="81" mass="8670" checksum="113098B61FF03739" modified="2019-02-13" version="1">MELSPEEYGAYWRASIRVAAGLVFVSLCYWFVVSPLLGHSDVGAVLMGIAMFGAVVFVGTFAAMLGLARVVRIAVDAEMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3L0</accession>
    <name>A0A3N6P3L0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89895">
        <property type="protein sequence ID" value="RQG89895"/>
        <property type="gene ID" value="EA462_07745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036681">
        <property type="entry name" value="PgpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101307">
        <property type="entry name" value="SSF101307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="165" mass="18175" checksum="092E2731F8B81878" modified="2019-02-13" version="1">MNVTRERVGTEREWIKNRSNTVVPVINDVRDDLGEIFDTDVDPVTETQYVDEVDTVFADGDLAVNVAALVAILRELDVTGDHPGFVVDELLGRELAATIAGTQPLRTLGEATFHYADLHVHGDDDENAGVDDLEAALAAGFQERIPGWSWTERESPFALESTERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3W2</accession>
    <name>A0A3N6P3W2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_08575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90045">
        <property type="protein sequence ID" value="RQG90045"/>
        <property type="gene ID" value="EA462_08575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="119"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="225"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG90045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="374" mass="40006" checksum="FBDFA977126E398D" modified="2019-02-13" version="1">MELSDEQELVRETVRSFVANEVAPAVGEADATQTFPEGVWDGLAELGLTGLSVSDAYGGDDAGAVTQSIVNEELAYGHLSVATALSVHILATACIREFGTEDHREEWLPKMAAGRPVGAFALSEADAGSNPAEMSTQARLEDGEYVIDGRKQWITNGQRAGVVILFAKTDRDDPDTVTQFLVPTDVDGFSVGKKEDKLGLRASDTTSLIFDGVRIPEANRLTDVGAGLKAAFSTLTGGRIAIASQAVGLAQAALDDALAYASEREQFGRPIADHQAIAHKLAEMGTDVRAARLLTRDAARKNDGDVDPMAASMAKYFASETAVDVTNEALQVHGGYGYTTAFDVERYYRDAKVTTIYEGTSEIQKNIIARHLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4C2</accession>
    <name>A0A3N6P4C2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92769">
        <property type="protein sequence ID" value="RQG92769"/>
        <property type="gene ID" value="EA462_00620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="145" mass="16171" checksum="A533D420417E30DF" modified="2019-02-13" version="1">MPTVTETRIRNRFRVQPNHANNNGTLHGGNLMKWLDEVGAMSALRFAGETCVTAQVNELNFERPIGIGDTALIESYVYDAGRTSVDVALQAWREEPRTGETERTTESSFTFVAIDEDDGPIPVPELTVATDDGERLRRRALEADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4M8</accession>
    <name>A0A3N6P4M8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92929">
        <property type="protein sequence ID" value="RQG92929"/>
        <property type="gene ID" value="EA462_01530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="318" mass="33369" checksum="E8E6003EA5938A37" modified="2019-02-13" version="1">MSELRSAAETAVEQCLALETDESCVVVTDDERESIGEALYAVASEITDDATLVKYPPGEQHGGEPPAPVAAALAGSDAFLAPTTKSLSHTRARSDATDGGSRGATLPGITESVFVTGLDADYDRILAECERTLECVAGADEVRVTTDRGTDITFEIGNREWFDDTGDVSESGSFSNLPAGEVFVSPESADGRYVVDGTMRPHGLLENETLEFVVEDGLVTEISDDEIREQVEAAAADVDDAAYNLAELGIGTNVGVTDLVGSVLLDEKAAGTVHIAIGDNAGIGGETEAPLHLDGIIRDPRVFVDGEELELPAADRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4S8</accession>
    <name>A0A3N6P4S8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_01955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92999">
        <property type="protein sequence ID" value="RQG92999"/>
        <property type="gene ID" value="EA462_01955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="290" mass="31730" checksum="693DF0D96BBD6DCB" modified="2019-02-13" version="1">MIERVITIPEQVTVRGKRVDDLLPWILSVPFALLFVLFLGIPLYRLFELSFQSETFLGHYVNIFAVGRYRNALFMSFAISILVTAVSIVLGLFMAYFLARREFTGKRLVVAIISFPISFPGVLVAWAMIVVLGRTGVLPQFLAFLSGESASTFAIVFSFWGLVAGYTYFTLPRVTMSMVSSIEKVDQNIEEAARSLGASRLQTFRHVTLPVIAPAIASAVTLAFSVCMAAFGTALLIASGVVDILPLMIFNVIMGQQDYAAGAAMAVVLTIITVSVIYGYRRKFGGSVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P638</accession>
    <name>A0A3N6P638_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps13</name>
        <name evidence="7" type="ORF">EA462_04125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91185">
        <property type="protein sequence ID" value="RQG91185"/>
        <property type="gene ID" value="EA462_04125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019977">
        <property type="entry name" value="Ribosomal_S13_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03629">
        <property type="entry name" value="uS13_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="173" mass="19810" checksum="4F11D8FACC786F7B" modified="2019-02-13" version="1">MSEEEPQEQQDDDDLRYFVRIGQTDLDGTKTIERSLSEMNGIGRRTARIIAEEADVDRTATFGRLDDDVIDEVVSLVESYADEVPNWLNNRQNDFYSGETTHEIGNDLQLSRQHDINRMKMIDSYKGSRHKRGQKVRGQRTKSTGRTEGTIGVNVEEIREEQAEEAAAEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6X9</accession>
    <name>A0A3N6P6X9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91645">
        <property type="protein sequence ID" value="RQG91645"/>
        <property type="gene ID" value="EA462_06770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="70" mass="7324" checksum="500F430E87D5F68C" modified="2019-02-13" version="1">MIEVRVNVELVAFGVMSIAVGVGLLSGVRYLYPRLDLTEGSLASVRLLTALIVGVLFLLGVGLIAVGILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P923</accession>
    <name>A0A3N6P923_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92715">
        <property type="protein sequence ID" value="RQG92715"/>
        <property type="gene ID" value="EA462_00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="176" mass="19798" checksum="25BB9A455529DF78" modified="2019-02-13" version="1">MRRRALLATAGTTTFAGCSLPTRCSRPSLRADHLEFESEELGSLSRWIGRETAILATRPAHIDRFEPPERIASENDVELSADDRERLERTAFDESFAVGIVVGSSGQSTSARVTHVVRENERVHCYICIRRRGTTDDWAPQIRLVRVETSWKPESVRVTFTDGRDGTETFDTDGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9U9</accession>
    <name>A0A3N6P9U9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93065">
        <property type="protein sequence ID" value="RQG93065"/>
        <property type="gene ID" value="EA462_02330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="140" mass="15041" checksum="DEDD7B2CF5EB3805" modified="2019-02-13" version="1">MVYITRALVDVLLDLANDADPNRVTTGVSVTNASELEGADGLPPETPVFTDFYLPNSGNAVNAVFGVDLSTPARQAQGQFVSHPVRELEVTKRDDLAQVIFVAVPPWTTDDDSFAAFGRDGERKRLEIIDAEPPAQSLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHI2</accession>
    <name>A0A3N6LHI2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_16955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86160">
        <property type="protein sequence ID" value="RQG86160"/>
        <property type="gene ID" value="EA462_16955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="139"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="258"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="375"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1057" mass="118079" checksum="AB48EC85BC26740A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHP1</accession>
    <name>A0A3N6LHP1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_17335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86115">
        <property type="protein sequence ID" value="RQG86115"/>
        <property type="gene ID" value="EA462_17335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="PTHR43675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="2">
        <location>
            <begin position="105"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="279" mass="29236" checksum="5105908C25F2C4B8" modified="2019-02-13" version="1">MTDHTAPTDDPSIDDASTRANADPGVTDDTTDRRSHVREEYGDVAAGEDGCCGSATAEADDGGVTVDPSRATALGYDDDDLAQAPDGANLGLGCGNPVAISALERGETVLDLGSGGGFDCFLAAREVGPDGRVIGVDMTPEMLERARENAAESEFDHVEFRLGEIEHLPVADASADTIISNCVVNLSPDKPRVFAEAYRVLRPGGSLSISDLVATEPLPPEVRDDPDAVVECVGDAARIEDLEAWLADAGFVDVAVTEEGEWSDELPIVSARIEARKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI19</accession>
    <name>A0A3N6LI19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Excinuclease ABC subunit UvrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">uvrA</name>
        <name evidence="16" type="ORF">EA462_14740</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86914">
        <property type="protein sequence ID" value="RQG86914"/>
        <property type="gene ID" value="EA462_14740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="630"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="963"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="963"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="664"/>
            <end position="671"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RQG86914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="987" mass="109166" checksum="03E5FF134BDC9353" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIR7</accession>
    <name>A0A3N6LIR7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87846">
        <property type="protein sequence ID" value="RQG87846"/>
        <property type="gene ID" value="EA462_13345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="67" mass="7716" checksum="8BFC1D15FBAF6AC6" modified="2019-02-13" version="1">MEYYVGHLPKTLLLSLVIIQRWFRTRTTRGNNGLSAVNGVLESTVFEMRNRSERPRVSRHGTNARAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ69</accession>
    <name>A0A3N6LJ69_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87911">
        <property type="protein sequence ID" value="RQG87911"/>
        <property type="gene ID" value="EA462_13695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="168" mass="17797" checksum="5DDE3B2ECCA46D3E" modified="2019-02-13" version="1">MTIVAAIDGTPSSETVVQTAHDVSSAFDEELIVLHVMEQEEYERIAERAKGPTSGTPSYPFTPSDSSVTLSTGGQSAEGYPIDTAAEDATTVARSFAEEALPADAAFSADGRVGEPTKKILESVERNDAHMLVIGGRKRSPVGKALFGSITQSVLLNSERPVLTCMHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJA8</accession>
    <name>A0A3N6LJA8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87981">
        <property type="protein sequence ID" value="RQG87981"/>
        <property type="gene ID" value="EA462_14075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="149" mass="15836" checksum="0D40131BC266F3FB" modified="2019-02-13" version="1">MARALFGPLGVVLALFPERVLEVYEEVALENPDECTAKSWIVPAIRAEGIVYVVATLAGGRAYAWLMNVAGVAGLAALAFPKQYLDFAASIGYERSDSVTWTDGFTTAVRLLGAAILVLSLRTFARRRRESATATADSPVADGTPGSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJV0</accession>
    <name>A0A3N6LJV0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88838">
        <property type="protein sequence ID" value="RQG88838"/>
        <property type="gene ID" value="EA462_10580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="153" mass="17363" checksum="9D8AA805B6D99721" modified="2019-02-13" version="1">MARTIKVDEDLYRDLGRYGNRDESWNDVLARVLAHIDEEAALEDRDNRETTHNSQETEAEDSALSQLPDGTVVRHRYQRGEYSGETVEATVQGGRLSVEGDTQETRSPTGAARIADKKLRDDDARGEGYNGWTWWEYETEDGDWEPITVLAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK09</accession>
    <name>A0A3N6LK09_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89103">
        <property type="protein sequence ID" value="RQG89103"/>
        <property type="gene ID" value="EA462_12075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="15"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="375" mass="41938" checksum="44902D713EB5F4DD" modified="2019-02-13" version="1">MRYTELGNSDVEVSEVGFGAWVVGTDWWGDRSEDDAIEMIRYAVDRGITYFDTGDVYGHGRSEELIGRALTDVRDEVTVATKVGYDFYNNPQAGHGELPKEMDPEYLRKAVERSLERLEMDSIDVLQLHNANVEEITPDILELLDELEEEGIIHATGLALGPSIGWLAEGDLAIEEEFDSVQLVWNVLEQEVGNHFLETIEETGSSTSLIPRVPHSSGILNEQVTPETELGEGDHRGFRPDEWYETGWEKLEKLRFLECAEQRSADDERAEQRSADDERAAEGDRERTMAQASIAWLLSHDPVATVTPTFRTTTDIDEWAAASDVPKLSSVELDRVEDLYENGFHIDRDDGMDALRSSVGGDDIESAGLDKLAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK91</accession>
    <name>A0A3N6LK91_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89173">
        <property type="protein sequence ID" value="RQG89173"/>
        <property type="gene ID" value="EA462_12460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="168" mass="17295" checksum="49A914DB959ACE23" modified="2019-02-13" version="1">MIQRRQVVLGLGALAAGAGLIGGSGAFDSVEADRDVSVEFSGDGDAVLGMSSADADREFVTVEADDDGVVGMTIERLNQNARTAVSNLIAFTNNGSRPIETITATIDDRSENAAVVVHDDLSGIPSIGVGETVVGLGLTIDTREENGHAGSPDVMGEIRIHASTLSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK97</accession>
    <name>A0A3N6LK97_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-methylthioadenosine/S-adenosylhomocysteine deaminase</fullName>
            <shortName evidence="1">MTA/SAH deaminase</shortName>
            <ecNumber evidence="1">3.5.4.28</ecNumber>
            <ecNumber evidence="1">3.5.4.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtaD</name>
        <name evidence="3" type="ORF">EA462_12515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:20716"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57985"/>
            <dbReference type="EC" id="3.5.4.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine</text>
            <dbReference type="Rhea" id="RHEA:25025"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:48595"/>
            <dbReference type="EC" id="3.5.4.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.28" evidence="1"/>
    <dbReference type="EC" id="3.5.4.31" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89183">
        <property type="protein sequence ID" value="RQG89183"/>
        <property type="gene ID" value="EA462_12515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090614">
        <property type="term" value="F:5'-methylthioadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050270">
        <property type="term" value="F:S-adenosylhomocysteine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01281">
        <property type="entry name" value="MTA_SAH_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023512">
        <property type="entry name" value="Deaminase_MtaD/DadD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="51"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="430" mass="45292" checksum="FCFE1CE6A5C3CC23" modified="2019-02-13" version="1">MTTLSITGGRVLLPSGTVTNADVLVDQDSGLILEIGDDLAGDEPLDASGSLVTPGFVNGHCHVAMTLLRGYADDKPLESWLREDIWPAEAELNPGDIRVGTELGLLEMIKSGTTAFADMYFEVPEIAAAVEQAGLRARLGHGVISVAKDDEAAREDARTGLEVAREYDGAADGRISTAFMPHSLTTVDGEYLAEFVPEARELDVPVHYHANETTDEVDPIVDEHGVRPLAYAAEKGMLEPGDFVAHGVHLDESEITALAEAGTSVIHCPASNMKLASGMTPVQRLLEAGVTVGLGTDGAASNNDLSMLDEARDAAMIGKLAADDASAVPASAVVEMMTRGSAEAIGLDSGRLEAGAPADLAVIDVDRPHLTPHHDLVSHLAYAAAAADVRHTVCDGRVLMRDREVKTLDEPSVLERASRTAASLVDRADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKN9</accession>
    <name>A0A3N6LKN9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoxR family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89238">
        <property type="protein sequence ID" value="RQG89238"/>
        <property type="gene ID" value="EA462_12805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="51"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="358" mass="38854" checksum="6BD1333FF8B1BA93" modified="2019-02-13" version="1">MNETNAPRSDRTETEQRATPKRVSETLSEEIGRVLVGNEWIVERLTIALLTRGHVLLEGVPGIAKTTIANLFARTTGLEYSRIQMTPDVLPADVTGTAIYRENRGEFDVHRGPIFANVVVADEINRATPKTQSALLEAMAERQVTIEDDTCPLPTPFLVVATQNPIEMEGVFELPEAQRDRFLFKLEVPLPDRSTERTLVDRFDSLPTLGPEMADPVVTTNEILLAREHVRDVHVAPSVKEYVLDLVRATRTHPNATHGGSPRATLAFVDAAKASAAIAGRGYVIPDDVKRLAEPVLAHRIVLSTDADIGGVEPAAVVADVVDSIEPPGADVIDAESDATTATDEGTRNGENEPHSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLG3</accession>
    <name>A0A3N6LLG3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87950">
        <property type="protein sequence ID" value="RQG87950"/>
        <property type="gene ID" value="EA462_13895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="109"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="360" mass="38996" checksum="86500BD2B19216B0" modified="2019-02-13" version="1">MRRRSFIKASGAVGTGLVIAGCTGDGNGDGNGTDDGNGTGNGNGNGNGDDTGNDDLEMPDTIRIGTPSPDAPTWEMSSHPGLQYALEDRGHDTDLTREQFTGFTGMAAAFVSDEADMGYMGLSSLINAIEEGFPLVGFAGYINEYVFPVVVSSDIDGWEDLRGGDVAIHDPDSISTPSAQITIREELGSIDDVNYRSILGTTNRLSALEAGEVDGAAVFDSGAYQAEAEGYGQVLSHPTEYDVLNQQTVALWVTLEENLEENPEVYGEIADCLRQGHGELYERDGDEVLDDALASGIYPDFDRENHQQSFEIIREAELWPDGIDITEEELERSLDVLEATGLIDEDRRLSRDEVFDDRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLJ3</accession>
    <name>A0A3N6LLJ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88000">
        <property type="protein sequence ID" value="RQG88000"/>
        <property type="gene ID" value="EA462_14175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006521">
        <property type="entry name" value="Tail_protein_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011748">
        <property type="entry name" value="Unchr_phage_tail-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09684">
        <property type="entry name" value="Tail_P2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02242">
        <property type="entry name" value="tail_TIGR02242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="731" mass="82628" checksum="2126352D90C80EE6" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLM0</accession>
    <name>A0A3N6LLM0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89903">
        <property type="protein sequence ID" value="RQG89903"/>
        <property type="gene ID" value="EA462_07785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="276" mass="29289" checksum="8354706C0DB58F53" modified="2019-02-13" version="1">MDVLIVGAGSMGTWVGRTIDADVTFVDIDADAASDAAAAIGGDADDLDGSTRYEVVCLAVPMTHVTDAVAGQADRAQRALVDVSGVMGPPLESMKAHAPGLERASLHPLFAPERAPGTIAVVRDRSGPVVDELLRRFERRGNDLVETDAIEHDEAMETVQATTHAAVLSFALAAKSVPDGFETPIYEQLRTLAEQMTEGTPRVYADIQETFDGADAVAEAATEIAAADGDELEALYRDAATRWQANDASGGTEDGRKSEARERERADEDGRSGEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM66</accession>
    <name>A0A3N6LM66_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88857">
        <property type="protein sequence ID" value="RQG88857"/>
        <property type="gene ID" value="EA462_10680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029470">
        <property type="entry name" value="PDDEXK_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14281">
        <property type="entry name" value="PDDEXK_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="457" mass="52934" checksum="E095DF4E2796C2BA" modified="2019-02-13" version="1">MIFYVTRVHCVSAEKQLQELVQRLNRLPDANEPPPTTLQILGRNHQEQDWQRLLFHFLSPGKGHGLDHGLLEHLLSSLSKREDLDYTFSRLDLQDIKVETEVVTSNDTRPDAVLWLPGDWFICWELKLWASETHEQTKAYIDASSFPAIELSKDEVPVDNRHYIYLAPESASSPEANEFVQISWEWIASELQTFLAESQGGYPARTTAQLDDFISTIQQELTMTEHQKNQQEKAQLYFDYYDELQDVQSAFENQWDDFTDNWGLRLARELDGVEIVEIPDLSDNHVGIELNPDSEESARWIFRQGSSWAGIAKEQWRRRRTGDYAVIYGAPDDDNYAHITLYHRLEKNRKKAIQDGILELTLWHGNSSDNEFYKLVNDRVTKKIDEREYELPPTVELTNRTGNILTATYNIPIAEHDDFFDAYTAGLGDAFVDLAVENSELITIVDEAFDESLEEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM90</accession>
    <name>A0A3N6LM90_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86211">
        <property type="protein sequence ID" value="RQG86211"/>
        <property type="gene ID" value="EA462_16950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="559" mass="59834" checksum="8DA6F7DAF319A99E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMQ1</accession>
    <name>A0A3N6LMQ1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_09965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90388">
        <property type="protein sequence ID" value="RQG90388"/>
        <property type="gene ID" value="EA462_09965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="7">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="725"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="6">
        <location>
            <begin position="968"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="606"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1111" mass="119176" checksum="C13BC3F5F40D6C8F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMX8</accession>
    <name>A0A3N6LMX8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89267">
        <property type="protein sequence ID" value="RQG89267"/>
        <property type="gene ID" value="EA462_10825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="533" mass="56748" checksum="C87DAB8D4F6AD9C1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPI4</accession>
    <name>A0A3N6LPI4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91383">
        <property type="protein sequence ID" value="RQG91383"/>
        <property type="gene ID" value="EA462_05265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="70" mass="7478" checksum="1C24907FCCA12E35" modified="2019-02-13" version="1">MSIDRHAAERRRFARLLGTDGEVGSGLPIGSRSSSVSKSAREERRTDGADDERVTDFGSEGAVGADPRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPT6</accession>
    <name>A0A3N6LPT6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91523">
        <property type="protein sequence ID" value="RQG91523"/>
        <property type="gene ID" value="EA462_06060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="308" mass="34708" checksum="8128D7B3E3A410E8" modified="2019-02-13" version="1">MANYVVAMDEGLVSVIIPTYYRNNELESAIESVLRQTYKNCEVIVVDDSGEQYAKSLVDCYDGVNYIGLEENRGANYARSIGTYKSNGCAIQFLDDDDIIHEKKIEKQMALLNRYSGVVYCGFQRNNIIHLPPERGKGNVLKVTLGFDLNKCITSSMLIRTDLVKDILPFPNLPGSDDTYLKIELAKRTCFDFVSEPLVEKRSLNDSRGSGEGALYGMKEVIELFDGLYNEYDPEVKKSAISSFYLRKGSLELEKSGWSHRATIDIFKSLVYSPNIFNIGYFLCAIFGRPGVKVGKFIFNKASNNRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPT9</accession>
    <name>A0A3N6LPT9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)</fullName>
            <ecNumber evidence="2">2.5.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl diphosphate synthase</fullName>
            <shortName evidence="2">UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl pyrophosphate synthase</fullName>
            <shortName evidence="2">UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">uppS</name>
        <name evidence="4" type="ORF">EA462_11000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27622"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:60388"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88914">
        <property type="protein sequence ID" value="RQG88914"/>
        <property type="gene ID" value="EA462_11000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="327" mass="36921" checksum="233A0F0F724E6BDB" modified="2019-02-13" version="1">MKRWLRQRVDAAYERLLSREIAGAPTHVAVIQDGNRRYARGRGGDAHDGHRAGAETTERVLEWCQDVGVEELTLYTFSTENFDRPPEENERLFDLLVEKLREFADADRVHENGVCIRAIGETGLLPERVREAVAYAEERTRDYDQFVLNIALAYGGRSRLLEAARGVATEVDGGAIEPDQIDVEAIENRLYDQPVRDVDLIIRTGGDERTSNFLPWHANGNEAAVFFCTPYWPEFSKADFLRGIRTYEHRKESWRRTRARRALALLAAMSEPDLPEARSVVDRFRDSLPTAERSDLEEIEGKESAEETGQPGGQGVESIDSSGRAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPZ0</accession>
    <name>A0A3N6LPZ0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0179 protein EA462_06620</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0179 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91618">
        <property type="protein sequence ID" value="RQG91618"/>
        <property type="gene ID" value="EA462_06620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00498">
        <property type="entry name" value="UPF0179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005369">
        <property type="entry name" value="UPF0179"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40699">
        <property type="entry name" value="PTHR40699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03684">
        <property type="entry name" value="UPF0179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006595">
        <property type="entry name" value="UCP006595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="148" mass="15934" checksum="9AA7909A17E1C37B" modified="2019-02-13" version="1">MSTVTLVGSRLAEPGTEFVYQGEADGCAGCPYRSQCLNLSADTRYRVTSVRENAQTLECAMHDGGVRAVEVEPVSIRATIPSKGAFAGSKASLPGPCPYVECPSHEYCEPDGLAFDAEYRIDEIVGDPPHDVCHLDRSLELVELEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRW8</accession>
    <name>A0A3N6LRW8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="6">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gltX</name>
        <name evidence="11" type="ORF">EA462_04245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91207">
        <property type="protein sequence ID" value="RQG91207"/>
        <property type="gene ID" value="EA462_04245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="9">
        <location>
            <begin position="107"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="10">
        <location>
            <begin position="420"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="6">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG91207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="572" mass="65086" checksum="6CFC5100A87688B2" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSA5</accession>
    <name>A0A3N6LSA5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper-bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92778">
        <property type="protein sequence ID" value="RQG92778"/>
        <property type="gene ID" value="EA462_00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="91"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="158" mass="16792" checksum="70A4A973A9DAA8C8" modified="2019-02-13" version="1">MTRKKAISRRTAMKLTGAAAATALVAGCSDDDNGNGNGNGNGNGDGEGVEIEPGTEILFDGQMSGWEGLEPAEIEGDVNPTLILQEGESYEIGWTEGDDNFHNIEIRDDGGDVVDGLETEEVDDPDDDQILEFEASGEMAEYVCDPHPNSMVGELIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSL4</accession>
    <name>A0A3N6LSL4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0201 protein EA462_01615</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0201 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92943">
        <property type="protein sequence ID" value="RQG92943"/>
        <property type="gene ID" value="EA462_01615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01112">
        <property type="entry name" value="UPF0201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39652">
        <property type="entry name" value="PTHR39652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="137" mass="15334" checksum="9EB30E7D0345751E" modified="2019-02-13" version="1">MTDIYRVDVEITAPVYDTEVTSRVADAVVNVFPNADLEEGFGEISAQTHSMDHFSDLLHRQEILDTARGEFFANRDGDTFSFALKKQAAFEDRVNFSVGTPDELGEISVRVRVEEPTLEAYVDHIAPPTEDGRPIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSL9</accession>
    <name>A0A3N6LSL9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92953">
        <property type="protein sequence ID" value="RQG92953"/>
        <property type="gene ID" value="EA462_01675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="129" mass="14416" checksum="56AD9BB1E784DF1D" modified="2019-02-13" version="1">MPTVEYLNYEVVDDNGWDIYDDGVFEEAADAGLDNEDYGTLEVNEGEYILEAAEAQGYDWPFSCRAGACANCAAIIIEGEIDMDMQQILSDEEVEEKNVVLTCIGSAETDEVKIVYNAKHLDYLQNRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSR4</accession>
    <name>A0A3N6LSR4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_06440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91587">
        <property type="protein sequence ID" value="RQG91587"/>
        <property type="gene ID" value="EA462_06440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="224" mass="24779" checksum="5E1A403FC8D7AD0D" modified="2019-02-13" version="1">MAQATLTVTLPEQVWVQQISTRYPDATFRVLAAVPDAKTGFALVRIAGPAVREIVTDIENHSQILELSIVQWSDEEATIHFETTAPLLLFSSRASGMPIELPVEIRDGRATLEVAGSRDRLAELAGQLEQFGLQYRIESVSERLHDGQLLSDRQLEVVAAAVEVGYYDTPRRSSLTELANHLDIAKSTCSETLHRAEEAIVKRFLEDVPGLEDDDSLEEQLAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT30</accession>
    <name>A0A3N6LT30_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93153">
        <property type="protein sequence ID" value="RQG93153"/>
        <property type="gene ID" value="EA462_02825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="92" mass="10634" checksum="22A8215A977325DD" modified="2019-02-13" version="1">MSTSVKVTDTTKSRLEELQAEIRLETGRNVTQQDLLERIVTSSYESKDEVIDSFRDEFEPLSDEEIDRWLSGSSDWEVETSEEEIDDVLYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT86</accession>
    <name>A0A3N6LT86_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93248">
        <property type="protein sequence ID" value="RQG93248"/>
        <property type="gene ID" value="EA462_03385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="6849" checksum="3C2874920764FC73" modified="2019-02-13" version="1">MVISGDTLVAAVHSAVSMGDITGKYMSDEFLTRISSPRDGKTALARGLTTVRDRSASDRMRSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV02</accession>
    <name>A0A3N6LV02_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.117</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91454">
        <property type="protein sequence ID" value="RQG91454"/>
        <property type="gene ID" value="EA462_05675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.166.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023180">
        <property type="entry name" value="THP_succinylTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037133">
        <property type="entry name" value="THP_succinylTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14805">
        <property type="entry name" value="THDPS_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_N_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="278" mass="29774" checksum="9CFCE54CF8840401" modified="2019-02-13" version="1">MSTLEADVRELWERKQNDAVDARSAGTDELATLDEFVAALEAGDVRAAEPADGTWEANEWVKQGILLNFGLRETRPREYGGVTYNDVLPLADTSDYGDRGSRNTPDGTVVRRGAHVGSDCILMSPAFVNIGAHIGDGTLVDSCDTVGSCAQIGENVKLGANTLIGGVLEPVEDAPVIVEDDVSLGAGCRVTSGFVVGENSVVGENTLLTPRIPVYDLVEEEVIYGELPADRRAFTRFVESSISDHELFEGGAYKPAVVATDLAQETLEATEREDALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVE1</accession>
    <name>A0A3N6LVE1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">engB</name>
        <name evidence="9" type="ORF">EA462_00110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92677">
        <property type="protein sequence ID" value="RQG92677"/>
        <property type="gene ID" value="EA462_00110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="8">
        <location>
            <begin position="8"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG92677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="205" mass="23547" checksum="74BD3F31E4210FC3" modified="2019-02-13" version="1">MFDTRPDREAEVVLVGRSNVGKSTLMREVTGHSFDTGGSPGVTREPNHYDWAPEDFVLTDLPGFGFMSGVHEDRREEIKTNIVRYLEEYAENVLVAILVVDGKSAVDIIDRHSGPDEIPYDVEMFHFLRELGVPTVVAVNKMDKVDDRDERLDELCDRLGLYPPWKQWQEVIAPITAKSGRIEPLNEAVREHLHEHQRDDLFKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVN3</accession>
    <name>A0A3N6LVN3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92817">
        <property type="protein sequence ID" value="RQG92817"/>
        <property type="gene ID" value="EA462_00900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="70" mass="8077" checksum="6785C8C5A61C23A8" modified="2019-02-13" version="1">MAITMQEDEVSSLITEEIDGIEDDSLQSFIEAIVQHERSHLDNKFAEFNDKYDELVKNHADNQSLDDFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LW54</accession>
    <name>A0A3N6LW54_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93047">
        <property type="protein sequence ID" value="RQG93047"/>
        <property type="gene ID" value="EA462_02210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="566" mass="64521" checksum="102F0077FFDE6465" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWM9</accession>
    <name>A0A3N6LWM9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trk system potassium transporter TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trkA</name>
        <name evidence="7" type="ORF">EA462_00495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a potassium transport system.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93277">
        <property type="protein sequence ID" value="RQG93277"/>
        <property type="gene ID" value="EA462_00495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="139"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="229"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="364"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG93277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="445" mass="48283" checksum="4ABD8D5CD0E1D157" modified="2019-02-13" version="1">MRVIIVGAGEVGTNIADSLEEDHDVVVIDRDSDRVESITYDLDVLAIQGDGTSIETLQRAGLEEAEMVIASTDGDETNIVVCGAAKTVGDPFTIARVKKTNLLRTWEGATNAFGVDFMVCTDLHTAQTVVDIAGLPDARDVDSFADGLVRMAEFEIDPESPVAGETIAEADRFESLTFAAILRDDDIVVPKGNTVIQAHDAVVVIGSVESVREFAGGLTPTPTLEQADEIVIVGGSEIGYQAARLFEAEGLEPRLLERDHERARELAERLPETLVLESDATDIDFLVREHVDDSDIVVAALDSDEKNLLVSLLAKRIGVERTLGIVEAGEYVDLFETVGIDVAINPRVVTAEEITRFTREQRTENLAMLEHDRAEVLEIEVDRDSLLFGNRIRNVTSELPDGVVIGAVTRGEELITPRGETVLELGDHVVVFVDTDVLDEVSAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LX02</accession>
    <name>A0A3N6LX02_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="6">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purC</name>
        <name evidence="8" type="ORF">EA462_17240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86117">
        <property type="protein sequence ID" value="RQG86117"/>
        <property type="gene ID" value="EA462_17240"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="7">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="339" mass="38122" checksum="8F01C3C1FFED5B3B" modified="2019-02-13" version="1">MTSVKEFRVESEPGEDSLGRGAFVFTDDYSVFDWGKMPDQIPKKGAALCTMGAFNFELLEEAGVSTHYRGVVESGDVLPLERVTTPPVEMAIDLTRVPDLPHEGREYDYDHYHDVAGTNYLIPLEIVFRNRVPVGSSLRRRTEPADHGLEFDDWPAEAVDLAEPIVEFSTKYEEGDRYLAREEANTIAGNAAIENLETLAREVNRIITEQAESVGLDHQDGKIECLFIDGEIRVADVVGTFDENRFSYEGIQLSKEVLRQYHKRTQPTWVQAVETAKAEAKREEIADWKSLCERDPEPLEEPVLEVARDMYCAGSNAYTESELFDVPPLSSAIGAVQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LX22</accession>
    <name>A0A3N6LX22_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S17e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps17e</name>
        <name evidence="5" type="ORF">EA462_16885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86147">
        <property type="protein sequence ID" value="RQG86147"/>
        <property type="gene ID" value="EA462_16885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_S17e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_S17e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="RPS17e-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="PTHR10732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="SSF116820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="63" mass="7073" checksum="064603F34378F4D3" modified="2019-02-13" version="1">MAIKPAYVKKTGNLLLERYPDAFTTDFEQNKDSVTKLTNVESKGVRNRIAGYVTRKKSAQIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXD4</accession>
    <name>A0A3N6LXD4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylpropionate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86701">
        <property type="protein sequence ID" value="RQG86701"/>
        <property type="gene ID" value="EA462_16305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00667">
        <property type="entry name" value="ring_hydroxylating_dioxygenases_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000391">
        <property type="entry name" value="Rng_hydr_dOase-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41534">
        <property type="entry name" value="PTHR41534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00866">
        <property type="entry name" value="Ring_hydroxyl_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="172" mass="20263" checksum="92B8B3EC6591F51D" modified="2019-02-13" version="1">MWDIDARSVRESCEKFLYTEAQLLDDRDLLEWHETIITDDIEYRIPIRTTKERSAETEFSDESFHMIEDWGSLKVRVERMENDFAWSEDPPSRNRRFVSNVRVTDENPENAEVSIRSNLLIHRLRASDTDPDLLSAERRDTLRRVDGSWQLTERTVLLDHTVIGTPSLSIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYE4</accession>
    <name>A0A3N6LYE4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TrkA family potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_01280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a potassium transport system.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92884">
        <property type="protein sequence ID" value="RQG92884"/>
        <property type="gene ID" value="EA462_01280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="220" mass="23771" checksum="A52B120F4143396A" modified="2019-02-13" version="1">MKFVIVGYGRVGSRTARILVEEGHEPVVVDADTDRLKRAEEAGFVVVQGNGADEDVLVDAGIDTADAVGAFTPDLNVNFAACMVGKHHGCRTVMRIDEDYREDIYAKYAEDVDEIIYPERLGAAGAKTAMLGGDFNVVTDIAANLQLTVIEIREDSPAVGKRVSELELPDSSRIYAHGRERESLTIPIPGTELEAGDEVAIITESDRINEIRATLLPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYS0</accession>
    <name>A0A3N6LYS0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87823">
        <property type="protein sequence ID" value="RQG87823"/>
        <property type="gene ID" value="EA462_13210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="318" mass="33320" checksum="DAEEDF4A07272B88" modified="2019-02-13" version="1">MRANRYREYGEPNVLQVEDIEQPEPDRGEVVVAIEAAGVNPLDTKLRSGAYEWATPPMTPGADFAGVVTSVGPGVTDFAEDDRVFGTGLGIGRQGSCAEYVCASLEHVAQLPDNVSFEEGAALALVGVTSWEGMVEKAGLKAGDRCLVHGGSGGVGHVAVQVAKAAGASVTATASPQYHDQVEKLGADTVLDYSRDDLADAIASAGSPDVIMDHRINENIDLNTQVAAQGAQIVAISGTDIELSYSNSGMARGKMQTLHHFAMPQMSTFAPALERVATLAGNGQVSPVIERTYGLDEVAQAHEDVVEESFLGKLVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYW8</accession>
    <name>A0A3N6LYW8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87893">
        <property type="protein sequence ID" value="RQG87893"/>
        <property type="gene ID" value="EA462_13605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="7"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="544" mass="60420" checksum="4C6CAA314AF9879B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ13</accession>
    <name>A0A3N6LZ13_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RCK C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93124">
        <property type="protein sequence ID" value="RQG93124"/>
        <property type="gene ID" value="EA462_02665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="302"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="382" mass="40683" checksum="C377FF4BB793BDBD" modified="2019-02-13" version="1">MIATATQVVVTEWTVTALLNVFGFGLLASVAGATIAFGYRRYSTRPAPLGVGILIGIGVVGVWLNGVGLQQTTVIDETPLFHHATATYFLGAFVVGAVGADGGRRIGDALARDVFEIRCVVGSNERLTFARSARLSIAVDLPGTVGDLAGYPPVDEAVKQSIAGETVLFPHDLSDTVLESRLERHIEREYDVDYARVTLETNGTVEHVLVGRRPAGIGSTVPPGSVAVCVRADPPGRASAGDPIELWSTEKGSTSLRGTGTLRATTDESVTVSLEEDVAGELDVETRYRLVIRPTASSQVYELASVLRATDETIVSVSVTVNGPLETEFVGWLPGTVLVLHRDGEVIPFPRDRVTLEASDELYVLGTPSELRLLEETEKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ64</accession>
    <name>A0A3N6LZ64_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88023">
        <property type="protein sequence ID" value="RQG88023"/>
        <property type="gene ID" value="EA462_14300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="243"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="385"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="617" mass="67353" checksum="2503B79D6710A163" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZZ9</accession>
    <name>A0A3N6LZZ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88910">
        <property type="protein sequence ID" value="RQG88910"/>
        <property type="gene ID" value="EA462_10980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="135" mass="14178" checksum="C4E4B0074BF6DFCA" modified="2019-02-13" version="1">MPSTRRSVLGNAAAVGAILAAGCLDIEGEEPKYISISNWHEDPITIDVTITNVDTVEVVYDEALEFDGFAGPEEDGSPPSKKPDLGIGAEFEATVTAATDRDSVELTDDISPGAGAWIHVGHTPDAKLSISRDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0B1</accession>
    <name>A0A3N6M0B1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89050">
        <property type="protein sequence ID" value="RQG89050"/>
        <property type="gene ID" value="EA462_11765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040087">
        <property type="entry name" value="MJ0021-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43288:SF1">
        <property type="entry name" value="PTHR43288:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01108">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="331" mass="38020" checksum="E03A29DAE394920B" modified="2019-02-13" version="1">MISRGCEQCASGGKMVLFVYGYCDQRDCFYCPLGENRKNVTDVYANERRVESDEDVLEEAHRMDALGTSITGGEPQEALERTCHYLSLLKDEFGEDHHTHLYTGITGGRENMRKLSEAGLDEIRFHPPYEQWGDLHGTEWEDVLYVAREEGLTPAFEIPGIRAETEFLEFLDEGAAEFCNVNEFEMSQGNYRRMQTQGFELKEGHMSAVDGSREEILETMGDHERVYFCTSVFKDAAQHRRRLKRMARNVRREFDDVTDDGTLVYGKTTTDPARLVSLGVPEEFYTVKTNHVEVAWWLLEEMIEEGDIEDGEIVEQYPSYDGQVVERTPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1U6</accession>
    <name>A0A3N6M1U6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alanine--glyoxylate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_07000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89760">
        <property type="protein sequence ID" value="RQG89760"/>
        <property type="gene ID" value="EA462_07000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="44"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="400" mass="42965" checksum="D38D2312412DCB7E" modified="2019-02-13" version="1">MTERAGSTDAPAVDELTPPNRTLMGPGPSDVHPRVLRAMSTPLVGHLDPAFVEIMNEVQELLRYAFRTDNTWTIPVSGTGSAAMEAAIGNVVEPGETMLVPTNGYFGGRMASMARRAGGTVVEVDAPWGEPLETDAVAQAIADHDPDVFGFVHAETSTGVCQPNVPELSAVAHDHGALVVADAVTSLGGVELRVDEWNVDVAYAGPQKCLSCPPGASPLTLSDEAMEKVLAREEDPRSWYLDLSLLEGYWGDERAYHHTAPVTNVYALREALRLVATEGIENRWERHERLAGALKAGIEAMGLEMNASEEYWLPSLNAVRVPDGIDDGDVCRELLERYDLEIASGLGDLDGEIFRIGCMGHSARPENVVYVVTALGDVLDRMGAAVDPSAGVTAVRRTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1W6</accession>
    <name>A0A3N6M1W6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89081">
        <property type="protein sequence ID" value="RQG89081"/>
        <property type="gene ID" value="EA462_11935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="97" mass="10866" checksum="CC0CB15E8A4220D4" modified="2019-02-13" version="1">MEQTDEEEIEDLPPSAKLVFKVLEYDGPLTQKQIVEESMLSARTVRYALERLGEIGIVDEDIYFADARQSLYRLTEPVAADGKGVEEPAKKDACCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M202</accession>
    <name>A0A3N6M202_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1059 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89820">
        <property type="protein sequence ID" value="RQG89820"/>
        <property type="gene ID" value="EA462_07315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="57" mass="6700" checksum="CA25F71603105F4A" modified="2019-02-13" version="1">MTKAHKLDCESVSDECRFIIQSENEQEAIELAKKHMKEVHEADYTDEELQNEHLQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2U7</accession>
    <name>A0A3N6M2U7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Linear amide C-N hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_09175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90150">
        <property type="protein sequence ID" value="RQG90150"/>
        <property type="gene ID" value="EA462_09175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBAH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="329" mass="36352" checksum="4F38491251F06400" modified="2019-02-13" version="1">MCTRLVYLGPENRVLTARSMDWKEDIGTNIWVLPRGVERDGEVDSNSMTWTSEYGSVIATAYDIATTDGMNEAGLAANLLWLSESEYPERGGETPAMSISLWTQYMLDRFATVAEVVAHIRREDVTVVTEQVPGDDRLATVHLSLSDATGDSAILEYIDGELVVHHDRDFQVMTNSPTFDKQLALAEYWEEIGGTVMLPGTNRPADRFARASFYVDAIPQVEDRRTATAGVFGVIRNVSVPHGITTPDAPHISSTRWRSVADHKDRIYYFESALAPNAFWVELDELDFSVGSETRALDLGPDQSTVYAGDVSDQLQITDPFSFLGAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M347</accession>
    <name>A0A3N6M347_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_17265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86103">
        <property type="protein sequence ID" value="RQG86103"/>
        <property type="gene ID" value="EA462_17265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="2">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="3">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="136" mass="14905" checksum="C89E12899745316D" modified="2019-02-13" version="1">MVDDSTPVTVLSGTLGAGKTTVLNHILRESDEDLAVLVNEMGEVNVDADRIAESSDIAERWDDRWEDRSNRLVLIGTEMDHGAIRSEPANCLVADAELDDDPSTYEDRFPTFDSPEEQRSGADGVEDRQGKIGIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4H2</accession>
    <name>A0A3N6M4H2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EA462_15590</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87057">
        <property type="protein sequence ID" value="RQG87057"/>
        <property type="gene ID" value="EA462_15590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="94"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG87057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="303" mass="35383" checksum="6C165C60B2080FD1" modified="2019-02-13" version="1">MVRNVAGLLSELEEEDFYLLSGVEQGMRFSEWVQREKIPKFSRLTDEEVDYRLERCLKRGLIEKKTIQYEGYTLQFEGYDTLALRAFVERETISEFGSPLGVGKESDVYEVRSYKPFALKYHREGYTNFREVHKERDYTSDNDHVSWMYTARKAAEREYDVLETLYPDVAVPQPIDQNRHAIVMEKMNGVELSRTKLEDDQILGVLDLVLNEIARAHERGYVHADMSEYNVFVDEDGVTVFDWPQSVPTDHENADGFLHRDLENLLGYFRRKYPRAVPEDIETEEVVDSIATDSLEPIAKRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5G8</accession>
    <name>A0A3N6M5G8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_04580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91270">
        <property type="protein sequence ID" value="RQG91270"/>
        <property type="gene ID" value="EA462_04580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="21"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="5">
        <location>
            <begin position="412"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="686" mass="73855" checksum="224C3AB7ACC15650" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5I7</accession>
    <name>A0A3N6M5I7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">50S ribosomal protein L37e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpl37e</name>
        <name evidence="12" type="ORF">EA462_04700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10 11">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91290">
        <property type="protein sequence ID" value="RQG91290"/>
        <property type="gene ID" value="EA462_04700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_L37e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 10 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG91290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="58" mass="6397" checksum="E8D7AB40B3E29381" modified="2019-02-13" version="1">MTGAGTPSQGKKNKTTHTKCRRCGEKSYHTKKKVCSSCGFGKSAKRREYAWQSKAGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5Q8</accession>
    <name>A0A3N6M5Q8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl30</name>
        <name evidence="5" type="ORF">EA462_05130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91360">
        <property type="protein sequence ID" value="RQG91360"/>
        <property type="gene ID" value="EA462_05130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_A">
        <property type="entry name" value="Ribosomal_L30_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005997">
        <property type="entry name" value="Ribosomal_L30_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_L7_euk_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01309">
        <property type="entry name" value="uL30_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="4">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="155" mass="17101" checksum="36207690F7DD6CAB" modified="2019-02-13" version="1">MKAVVQVRGEVNRQEDVQDTLEMLNIHSVNHCALIPETDTYRGMITKVNDYVAHGVPESAVLETVLEKRAEPLEGSQSDVDEEWLADNTDYDDFAALAEALLAEETTLRDEGLSPTLRLHPPRGGHDGIKKPTAEGGQLGKHTTAQINDLLESMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5X6</accession>
    <name>A0A3N6M5X6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91430">
        <property type="protein sequence ID" value="RQG91430"/>
        <property type="gene ID" value="EA462_05515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="88" mass="9419" checksum="02AF55ED14B28987" modified="2019-02-13" version="1">MKRRTTLAIVGASIFTGAAVNATTATTDGGPRIVDIDSETSTEDVDAGDEYAIEYVDGRTVVVTARRRSPPLATRQPSPQSNPRRLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M625</accession>
    <name>A0A3N6M625_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="3">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="3">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">sucD</name>
        <name evidence="8" type="ORF">EA462_05825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15081"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91480">
        <property type="protein sequence ID" value="RQG91480"/>
        <property type="gene ID" value="EA462_05825"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="3">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="3">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="3 4">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="290" mass="29764" checksum="7F89BA0BFBD7A502" modified="2019-02-13" version="1">MSVLVDDDTRVVVQGITGGEGNFHAEQMIEYGTNVVAGAVPGKGGQEAAGVPVYDTVEEAVEEEDADTSVIFVPPAFAGDAIFEALDTNLDLAVAITEGVPTQDMARVNKRLSETETRLVGPNCPGLITPGEAKLGILPGNIFSSGNVGLVSRSGTLTYQVVDNLTNRGIGQTTAIGIGGDPIIGTDFVDALELFENDPETDAIAMCGEIGGEDEEEAAAFIDEHVDTPVAGFIAGRTAPPGKRMGHAGAIVSGSGTGTAESKINALNDAGVPVGDTPEEVADHIEAFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M673</accession>
    <name>A0A3N6M673_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91550">
        <property type="protein sequence ID" value="RQG91550"/>
        <property type="gene ID" value="EA462_06215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="14923" checksum="8C6BB05027403097" modified="2019-02-13" version="1">MSDSNLSAHHVGIAVDDLEATLAFYRDALGLSIIDRFSVSGEAFSDGIGVEDASGSFVHLEADGIRVELVEFDPKARDSPATGLNQPGTTHVAFAVDDLEVIANELPDDVPTISEPRTTASGTSILFVRDPEGNLIELLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6K3</accession>
    <name>A0A3N6M6K3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88946">
        <property type="protein sequence ID" value="RQG88946"/>
        <property type="gene ID" value="EA462_11175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="195" mass="21892" checksum="43F33B14461FF1FC" modified="2019-02-13" version="1">MSLLSLDPIAAYAPTAIDDQPYDAAVLAPIVDRDGEDHLLFTRRADHLGEHPGQMSFPGGGAERVDESILETALREADEEIGLDRSEVDVVGQLDDIRTVTEYAVTPFVARVPDRTYERDDYEVAEIVLLSVSALLDPENYEYERRDHPYYGDIVIHYFHVDGYTVWGATGRILVQLLELATPFEAPERVDRSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6M7</accession>
    <name>A0A3N6M6M7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88976">
        <property type="protein sequence ID" value="RQG88976"/>
        <property type="gene ID" value="EA462_11340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="246" mass="26593" checksum="50692385590776DF" modified="2019-02-13" version="1">MYEPDLEGQTVLVTGSATGVGRELLLATADCGASTAVHYHTSDDDARDVVARASERGAGETTTVQGDVTDPDSVDDIFAAVESDIGTVDVLVNNVGDFAPTHWADLEFETWNRVLETNLNGTYLCSKRALPAMRENGYGRIVNVGYASAERGLVSPKNFPYFVAKTGVLMFTRMLAADTQDDGITVNAISPYVVENSAEFPDELPRGRPARFEDVTRPLLFFLDDDAGYVSGENIEIDGGWLPESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M773</accession>
    <name>A0A3N6M773_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps9</name>
        <name evidence="9" type="ORF">EA462_04160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91191">
        <property type="protein sequence ID" value="RQG91191"/>
        <property type="gene ID" value="EA462_04160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_A">
        <property type="entry name" value="Ribosomal_S9_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019958">
        <property type="entry name" value="Ribosomal_S9_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03627">
        <property type="entry name" value="uS9_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="132" mass="14661" checksum="373FC4C73E35BD55" modified="2019-02-13" version="1">MVTNTSGKKKTAVARATVSEGEGRVRINSKPVELVEPEMSRLKMLEPFRIAGDELRSEMDIDVRIEGGGISGQADAVRTAIARGIVQHTNDAELRDAFMEFDRSLLVNDVRQSEPKKWGGPGARARYQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7V1</accession>
    <name>A0A3N6M7V1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metal-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_05470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91421">
        <property type="protein sequence ID" value="RQG91421"/>
        <property type="gene ID" value="EA462_05470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="9">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG91421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="226" mass="25395" checksum="9C2F36E2DD0668C3" modified="2019-02-13" version="1">MMLSDVMEDYLKVIYQLQQQTDDRIKTSEIADELDVTSPTVTSMLEKLEDRSLIDREKYRGVTLTTEGETVALEIVRHHRLLEAYLTEHLDYDWSEVHAEADRLEHHISEVFEARVAESLDDPEVDPHGSPIPSPDLEPPDRPDGDSVVECAEGETVVVEEVADHDPDILSYLSDHGVEPGLELEILEIAPFGMVTARSSESDESVSLPDDVARHVRVARTAEPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9C9</accession>
    <name>A0A3N6M9C9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92890">
        <property type="protein sequence ID" value="RQG92890"/>
        <property type="gene ID" value="EA462_01325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="80" mass="9315" checksum="B28B9B42FCB50879" modified="2019-02-13" version="1">MGETSEDIVESTLDTDSESEESRETEKSDNWDTEVITDSSSEHRSDDVGVWKHRRFIRFAVIFYRSDRRTARGRSGNDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9D6</accession>
    <name>A0A3N6M9D6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="7" type="ORF">EA462_01375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92900">
        <property type="protein sequence ID" value="RQG92900"/>
        <property type="gene ID" value="EA462_01375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="624"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="673"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="778" mass="83846" checksum="DD46CAA34792B875" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9R9</accession>
    <name>A0A3N6M9R9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90296">
        <property type="protein sequence ID" value="RQG90296"/>
        <property type="gene ID" value="EA462_09980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="258" mass="27826" checksum="650AFDD14262F488" modified="2019-02-13" version="1">MRTKMAPDLPEKLPGIDIDEADDDRRRESLDESEAALRVVRFEIGTHQLAVPVDVVRTIADVPSDFTRVPRAPKAIEGLTDLRGEVTAVIDLTAYFPSDDGHPDANQLLVFDPPADEQPAAIRVSEVLGIDTVSDDDITDAADTDVLEYSGDALEHPLVEALIERERQSIPQEGKRSPTEVTLEAADGTNRSERGSTALDRPTSSDAASDSELVESNGDKRISTGSGERSQRRVVVDVVPLVSVEDVLLASGHPISAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9W1</accession>
    <name>A0A3N6M9W1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93090">
        <property type="protein sequence ID" value="RQG93090"/>
        <property type="gene ID" value="EA462_02485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="6666" checksum="822FA941142F3E2E" modified="2019-02-13" version="1">MTPTFEEELDQSSISAVVIENPYSANECVLYPSNATDEKLETMWVLAKDGDYTCLEDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MB75</accession>
    <name>A0A3N6MB75_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92711">
        <property type="protein sequence ID" value="RQG92711"/>
        <property type="gene ID" value="EA462_00300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043868">
        <property type="entry name" value="DUF5828"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19146">
        <property type="entry name" value="DUF5828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="240" mass="27127" checksum="D1F76B66549D82AB" modified="2019-02-13" version="1">MEESISGFKVRGDWGDVVEHGERITRALRDADVHDPDEDTNARFSRAFDEWEEWRPKAHERLESDVSEKTAEQASVEEGKGEKAGKKPDEDIKTAGEKLSESYEQLEEDDPEAAVDNWRESIDYVARAADSAGRKALRRVEDTVYQNVMTQLAPYYFDNELISANIQQSTRGTDNGQQFAFEVNVNDDVLKDEVSDRLAELDDEIDRWHVEVEKDTDAAEAIEGAEAPPEPTDNSKSTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MB85</accession>
    <name>A0A3N6MB85_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF433 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92721">
        <property type="protein sequence ID" value="RQG92721"/>
        <property type="gene ID" value="EA462_00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="101" mass="11290" checksum="3EABE385F09A6850" modified="2019-02-13" version="1">MSIVQDPEHSDGAPTIEDTGIREKDIVVAYEHSGYKPGEITQLYPDPLLGDVHRALAYYYTVGQNYLKIGRSPAAVSDGDGREFVTDFPLTSVRQYQWGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBW1</accession>
    <name>A0A3N6MBW1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91166">
        <property type="protein sequence ID" value="RQG91166"/>
        <property type="gene ID" value="EA462_03995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="840" mass="90838" checksum="0714A2612EF031AF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBX8</accession>
    <name>A0A3N6MBX8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps4</name>
        <name evidence="9" type="ORF">EA462_04130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91186">
        <property type="protein sequence ID" value="RQG91186"/>
        <property type="gene ID" value="EA462_04130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_A">
        <property type="entry name" value="Ribosomal_S4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_S4/S9_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022802">
        <property type="entry name" value="Ribosomal_S4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="7">
        <location>
            <begin position="104"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="173" mass="19872" checksum="66446794156873AB" modified="2019-02-13" version="1">MPLGTDTKQYETPNHPYQGERIASEHSLLDRYGLTNKEELWRAQSELRSYRREARDLLGQPQDDETVVRRSEEFLGRLKRAGILDEADDLGNVLSLEIEDVLERRLQTVVYRKGLANTPQQARQFITHGHVVVGAQRHRVPSYVVDVDEEDLVAFDENSPLADELHPERAEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBY3</accession>
    <name>A0A3N6MBY3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HTTM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_01910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92991">
        <property type="protein sequence ID" value="RQG92991"/>
        <property type="gene ID" value="EA462_01910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008488">
        <property type="term" value="F:gamma-glutamyl carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017187">
        <property type="term" value="P:peptidyl-glutamic acid carboxylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007782">
        <property type="entry name" value="VKG_COase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05090">
        <property type="entry name" value="VKG_Carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM" evidence="6">
        <location>
            <begin position="23"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="540" mass="58845" checksum="AAD5C0706A289D61" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCG2</accession>
    <name>A0A3N6MCG2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase anchor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91416">
        <property type="protein sequence ID" value="RQG91416"/>
        <property type="gene ID" value="EA462_05440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013153">
        <property type="entry name" value="Prk_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010650">
        <property type="entry name" value="PrkA_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08298">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06798">
        <property type="entry name" value="PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00763">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA_PrkA" evidence="1">
        <location>
            <begin position="22"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="761" mass="87166" checksum="371C03B96F0713ED" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MD39</accession>
    <name>A0A3N6MD39_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91696">
        <property type="protein sequence ID" value="RQG91696"/>
        <property type="gene ID" value="EA462_04565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="69" mass="7848" checksum="B59C92E5A6CE4469" modified="2019-02-13" version="1">MSTEPSDAKWTPMTSSQQTNTPRCVSCGNQVTRQFSRVFGDNRDVVHACPECSTYREMKTSDFIPEDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFU2</accession>
    <name>A0A3N6MFU2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4129 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_00725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92786">
        <property type="protein sequence ID" value="RQG92786"/>
        <property type="gene ID" value="EA462_00725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="458"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="768" mass="82343" checksum="1652E25E6D0D763B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGB6</accession>
    <name>A0A3N6MGB6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="5">HAT</shortName>
            <ecNumber evidence="5">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Homoserine transacetylase</fullName>
            <shortName evidence="5">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">metX</name>
        <name evidence="5" type="synonym">metXA</name>
        <name evidence="8" type="ORF">EA462_01870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92986">
        <property type="protein sequence ID" value="RQG92986"/>
        <property type="gene ID" value="EA462_01870"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="37"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="402" mass="43525" checksum="D934EB8C71AD490D" modified="2019-02-13" version="1">MTTRDTVTIGAFQFLSGESVPSLEIAYESYGEFDGTNAVLICHALTGSSHVARRPDAGDDTAGQARAWWGDVVGPGKAIDTTEYFVVCANVPGSCYGSTGPASTNPETGDPYGTDFPPVTVGDWTRAQRALLDEIGVGRLHAVVGGSVGGMNVLDWLRRYPDDVEYAASIAAAARLDPQCLALDTVARRAITTDPDWNGGHYYGGPEPVDGLARARQIGHIMYLSKASMARKFGRRSAGRETVREKPPDPAAAFFPYREVESYLDYQAEKFTDRFDANSYLYMTRAMDDFDLAAGYESDADAIAAFEGELLVLSFTGDWHFTVEQSEALADACRETDVSVAHHIVESDHGHDAFLVEPEKVGPPLSDLLAVGLEGRSITDTEDEEIDEPEAFAPVHTSLFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRV5</accession>
    <name>A0A3N6MRV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87013">
        <property type="protein sequence ID" value="RQG87013"/>
        <property type="gene ID" value="EA462_15320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008719">
        <property type="entry name" value="N2O_reductase_NosL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41247">
        <property type="entry name" value="PTHR41247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05573">
        <property type="entry name" value="NosL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="211" mass="22990" checksum="22574B0AE80ABD8C" modified="2019-02-13" version="1">MTGLESEPLVRRRFIGAIGTGTAVCFAGCLGENGSGDDHGDHATHDDHQNGDGGENQFETSLEHPGNEPIEFADDLRCPVCNMVPAQYPQWQSQLAHENGDGAVFDTPGCLFAYYAVPPTDSPVTAVWVTDFESGDLIDATEAHFVIVTDETAVTGEVMEINPRPFADRDDAVAYLSEWDTEELTEDDIIGLEDVDREVAAIYRGNRLPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MS89</accession>
    <name>A0A3N6MS89_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Archaeosortase A</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">artA</name>
        <name evidence="11" type="ORF">EA462_15810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87093">
        <property type="protein sequence ID" value="RQG87093"/>
        <property type="gene ID" value="EA462_15810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014522">
        <property type="entry name" value="ArtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019127">
        <property type="entry name" value="Exosortase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09721">
        <property type="entry name" value="Exosortase_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025737">
        <property type="entry name" value="Cyco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04125">
        <property type="entry name" value="exosort_PGF_TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR025737-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG87093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="337" mass="36433" checksum="EF13B88FE7AC54D8" modified="2019-02-13" version="1">MPPSPATAGVDPSVALEFSTASALAPATLGLSLTDALAWLAIGAFFVAIVLQWRDVREPARLIASGAWLVFGVFWLTMAPYYYYDAQSPLQTVLSMAALPLCAYAGYLLYAGRESLFVLSKAVAIMGLIYLPAEMIPFVRQWLIETTAAQTHVGMELLGHSPGINEGANGHQSRFDFDPDETVTGRTTYIVLACTGIGSMAIFSGLIAAVKAPLKRKVAGIALAVGVIWLLNLVRNVFIGLASPWGWFQQDWLVSFMTTYTGAQPERVSFLVAHNYIAQSLSIVALVAITYLVVRIVPEVLEPLEEVLFVLTGNEYDLFEAMTTDGVRADGGSETDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSW4</accession>
    <name>A0A3N6MSW4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_13400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87855">
        <property type="protein sequence ID" value="RQG87855"/>
        <property type="gene ID" value="EA462_13400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="28757" checksum="28420C2C5BA7596F" modified="2019-02-13" version="1">MAQTNITTHNRIPRQFQRAAQSIINWIPIAIVIGFWELASGTVVANDVLPSPIIVAFEVNDLIISGDIYSHLFISIYRFAIGIGLSISIGVLLGISMARSKPIENFFDVFLSILYPIPKVALVPLAMLWLGVGTGPAILVVFLACLLPIILNSYNAAENVDQNLIWSAKMMGTDGWELLQKVVIPATIPNILTGIRQAIPIAFIALVSAELIASYEGIGYLILEAGQVGNYQVMFANIVIISVVAYLFVTGFEMLREKVIVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0F8</accession>
    <name>A0A3N6N0F8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91382">
        <property type="protein sequence ID" value="RQG91382"/>
        <property type="gene ID" value="EA462_05260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043851">
        <property type="entry name" value="DUF5813"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19130">
        <property type="entry name" value="DUF5813"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="171" mass="18810" checksum="604D3159CA603D3A" modified="2019-02-13" version="1">MTTVPPAIEQELESHDAFDQSDEDYTLTTTVFDTTVTAVDTNSGRGSRFLITVTLPTLDAAVANETVAPVVEDGWFETLERRLEDAFTVSHTDTHEKPTVDRDATDVRVTLEYVAGNARDGVEDAKALIEYVEGTFAQGIIPGYDYRGEAETLLGNAQSRGDRPLHNESRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0Y5</accession>
    <name>A0A3N6N0Y5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">gatA</name>
        <name evidence="10" type="ORF">EA462_06465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91592">
        <property type="protein sequence ID" value="RQG91592"/>
        <property type="gene ID" value="EA462_06465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="9">
        <location>
            <begin position="13"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG91592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="426" mass="44355" checksum="A78F23855C0924F3" modified="2019-02-13" version="1">MMSNIFITEETIEGAADGPLAGRTVAVKDNISTADVRTTCGSTMLEEYVPPYDATVVSRIKDAGATIVGKANMDEFGMGTTTETSAFGATDNPTAPGHVPGGSSGGSAAAVAADEADLALGSDTGGSVRCPAAFCGVVGIKPTYGLVSRYGLVAYANSLEQIGPFGETVEDAAALLDVIAGPDDRDGTTREPPGSSERPTSYADAATGDVDGLSIGVPTELLEGADDGVLETFWDAIGELETRGAKYHEVSLPSVEHAVEAYYVIAMSEASSNLARFDGVRYGHSGGYDGNWNEAFAAARREGFGDEVKRRILLGTYALSAGYHDKYYKKAQDARAWVKQDFDEALSEADVLASPTMPVPPFELGESLDDPLQMYLADANTVPVNLADLPAISVPAGETDGLPVGLQLVGPSFGEERLVRVASALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N500</accession>
    <name>A0A3N6N500_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_00795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93282">
        <property type="protein sequence ID" value="RQG93282"/>
        <property type="gene ID" value="EA462_00795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="186" mass="19105" checksum="2C3A4F16A88F0150" modified="2019-02-13" version="1">METTPVNQLESRVGGITLEGEPHALSAWFVVALRLTMGLAFLGAGVGKLSVVAGQPFDAGGYLMGASGPAAGLFGAMATNPALMEVVNVVVPATQILIGLALVAGAFVRLAALGGAMQMAMFYLASWDVAGPLGFVNSDLVYLMVFLAIAAFGAGRILGLDRVIETLEVGGEPLLERVPALRYVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NU86</accession>
    <name>A0A3N6NU86_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ring-hydroxylating oxygenase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_16300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86700">
        <property type="protein sequence ID" value="RQG86700"/>
        <property type="gene ID" value="EA462_16300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015881">
        <property type="entry name" value="Ring-hydroxy_dOase_2Fe2S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00570">
        <property type="entry name" value="RING_HYDROXYL_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="34"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="429" mass="48466" checksum="0A82B6F0E25231D9" modified="2019-02-13" version="1">MADALEEGEALLEILHDDEVFERELEEIFAKSWVYIGHESEIPEEGDYRQRSIGKDPFIFVRDENGEVQVLWDSCRHRGTKLCRAEKGNTTHFRCPYHGWTYRNTGELVGVPQKGNGFPDLDMEEKGLHGAPNVESYNGLVFASLDPDAPDLETYLGPSAWYLDLYFKLADMEVIGDPHRWEIDTDWKTPSENFYGDNYHVPMGHKSAIDVGIGSATAKGEKESELYAISDVGGHAFSIYQIPGEDFFWGHPPEVTETFHPERLTDEQYQIARQSGVSLGTIFPNLSFIYLGGSDDPEKDTVGTFCLRQWQPIEPGKMEAWNWIMAPKDAPQEYKDRVYEVGVGTFSLSGNFEVDDIGIWDGIPEAADSVFAEQVNATTVFSMGRGEDTLAEVDDSWPGPGTVYREGGMTDENQLEFYRKWHQTISEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUT3</accession>
    <name>A0A3N6NUT3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86970">
        <property type="protein sequence ID" value="RQG86970"/>
        <property type="gene ID" value="EA462_15050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="173" mass="17882" checksum="42FB6DB80382C337" modified="2019-02-13" version="1">MRLAHVTRLEAFGTRSLVIHGIMALSFISAILVGLFVGGQFGQVSFVALLNFTAGLWVAHSVHSLGNTANNGEYAGVLNELVDTDTGLDSGRFGRLLALIGAVTAVSLLTSAQVLAGALLSIAVVAVGAIALVTAMIGFLIALGASYDGAQEQALVDREQRSDRLDGQSASDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUZ7</accession>
    <name>A0A3N6NUZ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87070">
        <property type="protein sequence ID" value="RQG87070"/>
        <property type="gene ID" value="EA462_15675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="70" mass="7007" checksum="CD7703F0392CD597" modified="2019-02-13" version="1">MLERPDAVLAAIPLLAASGLVLRSLIAATGFGTGLLVAPLAPIGYLAAFALVVHELLVGPVAQRSNDGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVF0</accession>
    <name>A0A3N6NVF0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_13040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87792">
        <property type="protein sequence ID" value="RQG87792"/>
        <property type="gene ID" value="EA462_13040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="36"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="384" mass="41553" checksum="EAD2AB5B7FD41D3A" modified="2019-02-13" version="1">MRALVVDADWKPQPEYDVTDREQQTGRAMNASKIWTDPTLSLEERPRPTPGPEEVLVEVRYAGICGSDLSMVASGDDGYMHYSAYAKFPNTIGHEFSGRVVETGSDVRLFEDGDLVTSEVTDYCGRCNACRQGSPGHCTYFEQLGFTVPGAFAEYVTVPEKLCWDVSPLRQAYDDEDALLKAAATIEPATITYHGLFGRADGILPGDYHVYHGAGPIGLTGMNVSRGAGAGEVIAFEPSDERRAVARDLGFEHVYNPIERDPVETIDEVTGGEGADVHVETAGAVQQTYPAIEDSLAEGANVVHISNAGSDPEITLRKYQGSAAQIYGSEGHTGQRIYPRVIRMMASGSVDNLPIVTTTYPLANAEAALERASERIDGKVLLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWQ1</accession>
    <name>A0A3N6NWQ1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="1">3-dehydroquinase</shortName>
            <ecNumber evidence="1">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type I DHQase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Type I dehydroquinase</fullName>
            <shortName evidence="1">DHQ1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroD</name>
        <name evidence="2" type="ORF">EA462_11415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88989">
        <property type="protein sequence ID" value="RQG88989"/>
        <property type="gene ID" value="EA462_11415"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00214">
        <property type="entry name" value="AroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="3-dehydroquinate binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="228" mass="24149" checksum="F9CCE6AE5AB0D094" modified="2019-02-13" version="1">MGIDFDSFVLTAATADLDDEPAAREHADAVEYRMDLAADPLEGLRAYDGELPILATNRAAWEGGEWDGDDDERLAALEEALATDAVEAIDVELESLRSGAATDLRTSARDHGVSVVASAHDFEATPDEIELMDTLSDACERADVGKLATTAETRADTLALLAVTHRLTESGRTVATMAMGEAGSHTRAVAPVYGSKIGYAPVDPAEATAPGQYDLETLSRLIATLENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYD0</accession>
    <name>A0A3N6NYD0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="4">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">ImGP synthase subunit HisF</fullName>
            <shortName evidence="4">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">hisF</name>
        <name evidence="6" type="ORF">EA462_07310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89819">
        <property type="protein sequence ID" value="RQG89819"/>
        <property type="gene ID" value="EA462_07310"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="271" mass="29448" checksum="45E03A78FD79F2F7" modified="2019-02-13" version="1">MVLTKRIIPCIDVDLDEDGNPAVYTGVHFEDLEYTGDPVEMAKAYNESGADEFVFLDITASAEGRETMLDVVERVADEVFIPLTVGGGIRTTDDIKETLRAGADKVSITTGAIERPQLITEGARAFGSQCIVISVDARRRFDEEGEHYVDIDGESCWFECTKKGGREGTGIDVLEWASEAEARGAGELFVNSIDKDGTKDGYDLPLTSAVCDAVETPVIASSGCGSPEDMYDVFTEADADAGLAASIFHFDEYSIEETKTYLDEHDVPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYI7</accession>
    <name>A0A3N6NYI7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86102">
        <property type="protein sequence ID" value="RQG86102"/>
        <property type="gene ID" value="EA462_17260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="74" mass="8210" checksum="DBB51B0FA0981B25" modified="2019-02-13" version="1">MIPVTDRDTDGDYPSTDGSLSNEGDVSPCYQAYIDQRGEVPDVCTIYVAFNTESTRTQWITARGDAFVARENAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYJ0</accession>
    <name>A0A3N6NYJ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase expression protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_17320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86112">
        <property type="protein sequence ID" value="RQG86112"/>
        <property type="gene ID" value="EA462_17320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="46"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="157"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="337" mass="35530" checksum="8F4944DC1F6D1815" modified="2019-02-13" version="1">MSDLGKIDRAFFDRHVAPNLGAERTDVAVGPQHGVDFGVIDVDGTALVTATDPLSILPALGFERAARFALDLVLADVAVSGVPPSHLSICFTLPETMTDEEFETVWTTIHNECADLGVAVVTGHTARYSDPSHPWVGAATAMGVGEHDDVVRPDGARVGDRLLLTTGPAVEAVGLLSTLFPDQLELSDDVVADAQQRLEEVYCVRDALTAVTAGPVTAMHDVTEGGLAGALNEMATGAGVRFDVDRDAVPMRAGVREVCESLEIDPWTATSCGSLLVAVEPSGVDAVRSALEDRDTVVAEIGRVEDGEGVVVDGERLEHPDVDPSWAAYAELADRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ32</accession>
    <name>A0A3N6NZ32_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86756">
        <property type="protein sequence ID" value="RQG86756"/>
        <property type="gene ID" value="EA462_16610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="92" mass="9862" checksum="3F17F00223B55284" modified="2019-02-13" version="1">MEPVEILYAVFSVTLITSGLVMAGMAVQAYAETQRTSMIYLSIGFTLIVAAASATTISAFVSGFQHPRTLLTVNYFVTTLGFVAVILSLYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZD4</accession>
    <name>A0A3N6NZD4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetate--CoA ligase</fullName>
            <ecNumber evidence="8">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acs</name>
        <name evidence="8" type="ORF">EA462_09995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90299">
        <property type="protein sequence ID" value="RQG90299"/>
        <property type="gene ID" value="EA462_09995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="7">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="5">
        <location>
            <begin position="97"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="6">
        <location>
            <begin position="542"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="656" mass="72468" checksum="44494B655D26BA03" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZG4</accession>
    <name>A0A3N6NZG4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfite oxidase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90349">
        <property type="protein sequence ID" value="RQG90349"/>
        <property type="gene ID" value="EA462_07335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="58"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="221" mass="24955" checksum="3FBB599AB7E9A7D0" modified="2019-02-13" version="1">MRANDVTDGGGDEVEDVTDDATDAVDSDVTDLYREFGDERLPPGQRETTAFPVLSKSGTPQWDPETWEFTVTGAVEEERSFTWEKFRALPSETQRQDFHCVTGWSKFDCAFTGVPFTELADRVGVSSDAVHVMFAGLDGYTTDLPLEDCLREEVLFAWGYNGEPLPDDHGGPLRVVTPHRYAYKGSKWVDSVEFLTEPEPGYWERRGYSQTANPWGEERYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZG6</accession>
    <name>A0A3N6NZG6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF1211 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EA462_14860</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86936">
        <property type="protein sequence ID" value="RQG86936"/>
        <property type="gene ID" value="EA462_14860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG86936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="209" mass="23429" checksum="DEF95CE557D868CF" modified="2019-02-13" version="1">MVRTLSGDGTDRMEALSDGLFAIVLTLLVLQFDVPEVSASELPTAIADQETLLVSYLLSFLVVGLYWIIHHNLFRYITRHDRLLLWMNLLFLLSISFLPYPTELLGMYGTQFAWTLYATNFALVGVFLTAVWSYATRAGFTDDRIDDRTAWLVTIRGMISPAVFVLSIGVAAVSLSIAFFVPVLIVPSQLVWARYYQRETGATDADEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZV0</accession>
    <name>A0A3N6NZV0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87116">
        <property type="protein sequence ID" value="RQG87116"/>
        <property type="gene ID" value="EA462_15945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="226" mass="25462" checksum="5555A9C9DDC25D3B" modified="2019-02-13" version="1">MQSANVLFDFPFPEERVFRYQAMQDILHHLVNNPFEEFTQQELASITGADVSSISRSLDLLDELGAITVSEDRPAQITIDEDHLQRPDPVFMIPQSEFRKPVQAYLDELETRLQESDELDELVGVVLFGSVARGTADRRSDIDLLIIVDGDLTYGRRICTSLARDIEAESFDGHRYEFEVLVETPDTAVSHGGELKEIFDEGLVLDRSNRLQELRQNIYASSGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0G6</accession>
    <name>A0A3N6P0G6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vitamin K epoxide reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_14005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87968">
        <property type="protein sequence ID" value="RQG87968"/>
        <property type="gene ID" value="EA462_14005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="11">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG87968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="108" mass="11540" checksum="93AE343469A1D35C" modified="2019-02-13" version="1">MTLTRLSALLHNYFDFQSIALAVVGWGASVFLTAVHFRALPLPAGVEPEGSLAVITSAWAYVGPIPLALLGAGYYVTMLVLGGLWLETKRELLERGIFAITLSPIPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1V4</accession>
    <name>A0A3N6P1V4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_12030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89095">
        <property type="protein sequence ID" value="RQG89095"/>
        <property type="gene ID" value="EA462_12030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="98"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="200" mass="21900" checksum="C06496980615C13B" modified="2019-02-13" version="1">MFTGIVEETGEIIARDRSDDGLRLRIGADGVATGLEHGQSISVSGACLTVERDEDGEWFEVFLATETLERTYLGELEVGDAVNVERAMPADGRFDGHVVQGHVDTVATISDVESVDEDWFFEFSLPAGYERYVVEKGSITLDGISLTVADLEDDGRVTVAIIPTTYDLTTLSEKSVGDPVHLEVDVLAKYVERLLETRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1W5</accession>
    <name>A0A3N6P1W5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89105">
        <property type="protein sequence ID" value="RQG89105"/>
        <property type="gene ID" value="EA462_12085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="299" mass="34140" checksum="AB1EF58D08C9427B" modified="2019-02-13" version="1">MTKRYVSLPDEAEAGMREFIDEVDERLSSDEDTCSVVEDVLLDLSGDRDAYDRWQDGESVSLATQVRLQSYDPCNTTLESEYYAEKDEAEFRRSKHLQWLWRQFDSLPIADNVEFALRFRRMLADHLFSDCGTDCRFFKGITFTYGHNISIGDNTVVHDDVHLDDRGTLTIGDRVSISDGVHIFSHDHDVVDQTEVRNYHTIIEDDVRLTYDSMVRAGNKVGENAIVGARGVVQNDVPAHHIVVGMPARSVKIKPGWESAATPIDEAGVNRQEERHLEYDIPDGLEVFDEFDRDLQLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P2C6</accession>
    <name>A0A3N6P2C6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91729">
        <property type="protein sequence ID" value="RQG91729"/>
        <property type="gene ID" value="EA462_06475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="PTHR17985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="27845" checksum="348705E1AD80F982" modified="2019-02-13" version="1">MCTLTLAWQVFEDAPVAVAANRDEALERDSLPPAVYRTDPLVVAPTDAAAGGTWIGYNEFGVFAGITNGWTDADLAGERSRGLLVADVLEAESVLAANAVLSDAVAADEYDAFNLVIADAEDAVCYRWDGHLDRTAFDPGVHVVVNAAVDDEVVVPPSRPDAAREQARNARRVRRALSVDTTDPGEPVEAWLERAGSVLADHEYGVCLHEDGFGTRSSSLIALGGTSTYRFAPGPPCRTSYEGVRSPTDSAGSDADGDVEGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3E1</accession>
    <name>A0A3N6P3E1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_07185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89795">
        <property type="protein sequence ID" value="RQG89795"/>
        <property type="gene ID" value="EA462_07185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014529">
        <property type="entry name" value="UCP026631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026631">
        <property type="entry name" value="UCP026631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="62"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="304"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="452"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="556" mass="62122" checksum="148D53FF9D4125D4" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4G6</accession>
    <name>A0A3N6P4G6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase/fumarate reductase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_09865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90275">
        <property type="protein sequence ID" value="RQG90275"/>
        <property type="gene ID" value="EA462_09865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer2_3" evidence="2">
        <location>
            <begin position="58"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="199"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="294" mass="34134" checksum="38B1AF9202DB58D8" modified="2019-02-13" version="1">MSTQQEQPREPESQEAPKDPEMKGSKSPQQERLRKKEAGLADERSEAEAEATGETVHIKVFRYDPEVEAKQEPRFDDFHVPFEKGMTVLDAVMYARDEFDSSLTFRHSCRQAVCGSDAFFVNGTQKLGCKTQISDLEQPVRIEPLPHQEVVKDLVVDMDHFYDQMHAVEPYFQQEDLPEGELEEQRQSRENREKVKMSTRCIWCGACMSSCNIAAGDNEYLGPAAINKAYRFAMDEREDEEIKEHRLRILEQEHGVWRCQTQFSCTEVCPKDIPLTEHIQELKREAVKKNLKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4H2</accession>
    <name>A0A3N6P4H2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90285">
        <property type="protein sequence ID" value="RQG90285"/>
        <property type="gene ID" value="EA462_09920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="184" mass="20256" checksum="BEE65ABE5256E3EF" modified="2019-02-13" version="1">MTRERPDPSRSAAIDRERRGQTTQDFVVGIGIFVLAVAFVFTTVPSFVATPTGSIDGGDTAQIDRVAATIVSDLETETPNELDGEAFNRTYSHHWNDENATEWLGLRTNADGDRFDRVNVTVRNLALSGADEPVELESGVSLAAGDTYRNQTDVRVTRIVTVTDINESGDLEQGDPLRLEVRMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P936</accession>
    <name>A0A3N6P936_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92735">
        <property type="protein sequence ID" value="RQG92735"/>
        <property type="gene ID" value="EA462_00435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="105" mass="11692" checksum="8B991222D6BC9C13" modified="2019-02-13" version="1">METRWATIDGVHIELPADCTVEQLRQAFRKPPSTVLVAVTGDLVSVVHDENRPLSEMVAGCADTYYFRSEDDQRRNEILAAPQIEDALVRPAGGETTFQRPGLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LH95</accession>
    <name>A0A3N6LH95_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="4">3.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_17250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86100">
        <property type="protein sequence ID" value="RQG86100"/>
        <property type="gene ID" value="EA462_17250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="316" mass="35118" checksum="BF08595413B11658" modified="2019-02-13" version="1">MTTDVTEITVIGDDDTGLVARVTSLLFERGINIEDLDQAVRDDVFRMYLAVDTSEMVCTEETLRTDLRELGDDLGLDVQVRFPADRETQRIAVLATKESHCLEALFEAWTNDKLGADIGVVIANHDDLQPLAEHYGVPFYDIGDQRGQQNEDELLEVLAEYDADLIVLARYMRILSPNVVFRYEDRIINVHPSLLPAFPGAEAYRQAVEEGVRVAGVTAHYVTTDLDQGPIITQRAFDVPDDADVEEMKRRGQPLEASALLEAVKLHLNGDVSVHRGRTTVRENGSTYQLGLPEEVDDVTPDRPVDGIARVISDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHM8</accession>
    <name>A0A3N6LHM8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose 1-dehydrogenase</fullName>
            <shortName evidence="6">GDH</shortName>
            <shortName evidence="6">GlcDH</shortName>
            <ecNumber evidence="6">1.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gdh</name>
        <name evidence="9" type="ORF">EA462_16100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glucose + NAD(+) = D-glucono-1,5-lactone + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14293"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glucose + NADP(+) = D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14405"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.47" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86664">
        <property type="protein sequence ID" value="RQG86664"/>
        <property type="gene ID" value="EA462_16100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047934">
        <property type="term" value="F:glucose 1-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047935">
        <property type="term" value="F:glucose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019595">
        <property type="term" value="P:non-phosphorylated glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02127">
        <property type="entry name" value="Glucose_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026583">
        <property type="entry name" value="Glc_1-DH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="7">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_dehyd_C" evidence="8">
        <location>
            <begin position="142"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="180"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="297"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG86664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="353" mass="38596" checksum="2A381F962795E33C" modified="2019-02-13" version="1">MKAIVVERGENTPSLIETPVPEPADGEALVRTLRVGIDGTDFEVLNGNHGGFPAGDDHQIIGHEAVGVVEDPNGTGLENGQLVVPTVRRPPEGSNEYFERGEPDMAPPGTYLERGIDGAHGFMSEYFTSPEEYLVTIPDEFAETGILVEPMSNTVKALEHAFASRSMFDWSPETALVLGNGPLGLLTLAMLDQTVERSYCLGRRDRPDPTIDIIDELGATYVDSRETPVSEIADVHEPVDFVYEATGYAKHAFETVEALAPNGVGVLLGIPEDWTFDIDGGRLHREIVLENKVILGSVNSHLRHFESAKESLARVPDWFTDDIITDVFSPINAEQALSSGNNRIKTVIEFDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIA7</accession>
    <name>A0A3N6LIA7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L15e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl15e</name>
        <name evidence="7" type="ORF">EA462_15640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87064">
        <property type="protein sequence ID" value="RQG87064"/>
        <property type="gene ID" value="EA462_15640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00256">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_L15e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020926">
        <property type="entry name" value="Ribosomal_L15e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="PTHR11847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="196" mass="22620" checksum="26757E4EEE235E21" modified="2019-02-13" version="1">MARSFYSHIKEAWKDPDDGKLGELQWQRKQEWRKQGAIERIDRPTRLDKARELGYKAKQGIVVTRVSVRKGTARKQRHKAGRRSKRQGVNRIGRRKNIQRIGEERVSRKYPNLRVLNSYWVGEDGSQKWFEVILVDPNHPAIENDDDLNWICDDAHNNRAFRGLTNAGKANRGLNNRGKGAEKVRPSNTGGQGRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJE2</accession>
    <name>A0A3N6LJE2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88031">
        <property type="protein sequence ID" value="RQG88031"/>
        <property type="gene ID" value="EA462_14360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="72"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="15009" checksum="6BB859BE57D41478" modified="2019-02-13" version="1">MPVTNLARSDVVTASTDESVQQLATMMDDESIGSVVITDGSEPVGIVTDRDLAIHLVAEAESPDDVTAADVMSSDLCTIEHDGGFYEATELMSEHGVRRLPVVDGDGSLSGIITIDDLNELLADEHQQLAAVVQAQRPPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJX2</accession>
    <name>A0A3N6LJX2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome-activating nucleotidase</fullName>
            <shortName evidence="5">PAN</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Proteasomal ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Proteasome regulatory ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Proteasome regulatory particle</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pan</name>
        <name evidence="9" type="ORF">EA462_11890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89073">
        <property type="protein sequence ID" value="RQG89073"/>
        <property type="gene ID" value="EA462_11890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022623">
        <property type="term" value="C:proteasome-activating nucleotidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00553">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023501">
        <property type="entry name" value="Nucleotidase_PAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="185"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="196"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="410" mass="46090" checksum="FDD814669ED506D9" modified="2019-02-13" version="1">MSRSPSLPDRPHREIDPDLPDDERFEALRGHFADLVDVHEQLEGQLEDAENRRQRLQERVDRVERENETLKSSSLYIATVEDVIDDGEVVVKQHGNNQEVLTEVSPRMAERVTAGDRVAVNDSFAIQTVLEAETDARAQSMEITERPSVGYEDIGGIDEQIREVREAVEQPLIEPELFEEVGIDPPSGVLLYGPPGTGKTMLAKAVANKTDATFIKMAGSELVRKFIGEGSRLVRDLFEMAREREPAIIFIDEIDAIAATRTESKTSGDAEVQRTMMQLLAEMDGFEARGEIRIIAATNRFDMLDRAILRPGRFDRLIEVPEPNRDGREQIFEIHTRGMNVTDDVDFDTLADDTEGYSGADIESLATEAGMFAIRNEREEIRHQDFLDAVEKVENDDSSDVVSSAGYFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK93</accession>
    <name>A0A3N6LK93_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_16835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86798">
        <property type="protein sequence ID" value="RQG86798"/>
        <property type="gene ID" value="EA462_16835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="340"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="420"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="501" mass="54458" checksum="E50EFDA0A3CB852C" modified="2019-02-13" version="1" fragment="single">MPSIPHRIRDRLGGYDLTSLSVTRRLRQAVPDRLRRSYVAKFGLVILAVLMLTIASASFFYIGISDEITDNTHDQLAYTADVESQELHTQLDSHQQLAERIAADDRIVDRQGMEIGARLSIEGAQTPREVVGIHYVDLETDRIIQSSERDPGTDDLSALDLRVHATDGGTITEHDYDDVDLTHLETTYTDTFEHNGQNVIALLSHVDHSDDDGAIVIVVSADLLAERFHEPLEGSYTEVVDTSADDVMISPNEESILAPYRDGVDQQGFDDIQHDAGTAEFDDTDEVVAYTVVPNTDWMLVTHAPQSSAYALADNVANSLIALIAVAIAGFLVIGATIGRSTANALGALADNATALSNGRTDIEIEDSGRIDEVGQVRDSFDDIRAYLETATAQSDAIARQEFDDPVLDQDVPGTLGNSLEAMGSDLESYIDDVEDAKAEAERSQAAAAEARHEAEELAERLEQKATEFGRVMGIAADGDLTQRLDDDVDNEALAEIAAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKA5</accession>
    <name>A0A3N6LKA5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89193">
        <property type="protein sequence ID" value="RQG89193"/>
        <property type="gene ID" value="EA462_12570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="215" mass="24967" checksum="5BE5382F77CC2CC0" modified="2019-02-13" version="1">MSQDDVPESLRAAADADRPRGILTPSDRDFLLGRKTDYTDHSKKQKRNRIRRRVRNAVLDFSILFEYMEERDRNTVFDPDDDERDAYTQGITDMLAFLHLGTMGYHTPFKDMLSEGVGKAEQRLAGSNYRMVNVEFNVDPVGQIDVDEVVAKLENEEFAQLTDEELRAFVRLLTMSDEFSPEASREEIKDRVDEYTERVTESEATRDRKLEELTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LL80</accession>
    <name>A0A3N6LL80_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87820">
        <property type="protein sequence ID" value="RQG87820"/>
        <property type="gene ID" value="EA462_13195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="408" mass="43558" checksum="BE9C4B8324E7DBC3" modified="2019-02-13" version="1">MKAPAAHVMLALGTIGYVWLMFVWLLVPAFLGPISDEFALSNTQAGLLTGAISFVYIPFALWSGILTDRIGAPRAIGYGMVLFGGAQVLRSVAHEFWSILLLTVLIGVGGTGITFGLPKLVSTLYPPERSGTMSSLYLVGMYAGTAAAFAVGRPIAGPLLGGWRPVFFFSGLAVLAFSVVWFLAYTWTKRRLPWRTDANRSVERSGDRNRSVSRDLRRLVLHRGVLLLAVVGFSYLLLVHGLQNWLTVILQERGLTTRIAVWTTSLFVVAQLVGTLVLPPLSDFKTSRRTALFSCGIFASAGTFVLLVADDAVFPILFAVFVAGFGLGGLATFVRSLPVEMKGVEGKLVASAVGLVFMIGEIGGFVGPLLVGAVADRTGSFSLSVFLLLLGSLAVIGASAFLTHADHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLI1</accession>
    <name>A0A3N6LLI1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87980">
        <property type="protein sequence ID" value="RQG87980"/>
        <property type="gene ID" value="EA462_14070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="195" mass="21578" checksum="3776672B7F71B848" modified="2019-02-13" version="1">MATKPRPVEQTLESTLIGRTVSFNYSETWVAYSIFGLRLVMAWVFLQAGLAKWADGGWGDPLAWSSTDFLNNVVAETNPLYELFLWFDSYAAIVDPLVIVGQILIGLALLFGIGFRFAALMGAIQMLFFWTAAWNAGLLAGFPVENGFFIDSSFVYMLLLFGLAAWGAGRLAGIDATLEETALVRENPWLRYLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLN4</accession>
    <name>A0A3N6LLN4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_07150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89788">
        <property type="protein sequence ID" value="RQG89788"/>
        <property type="gene ID" value="EA462_07150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010545">
        <property type="entry name" value="SPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06550">
        <property type="entry name" value="SPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="345" mass="35760" checksum="30CE7E661BFB336A" modified="2019-02-13" version="1">MNDRIRVLVAVGVTVLLFLAVQIGALALIEPFHESERQAVENPDDPTNSFIYFGIILVATALMLAAFKYDLQWLIRALIVGVSVMLAWFVFTEFVPPVITVGPANVLAVLAALGLGVALLSYPEWYVIDATGVLMGAGAAALFGISFGLLPAILLLSVLAIYDAISVYGTEHMLDLAEGVMDLKIPVILIVPTSLSYSYLAAGSTDDVLEGDGDGDDDGDDRSRVSGDEPADEDDGSEEAGHSDDGSLDRDALFIGLGDAVIPTILVVSAAFFLEAGTLEVPGIALNLPALGALLGTIAGLLVLLYMVLKGRPHAGLPLLNGGAIGGYLIGAVASGLSIVSALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLN6</accession>
    <name>A0A3N6LLN6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88070">
        <property type="protein sequence ID" value="RQG88070"/>
        <property type="gene ID" value="EA462_14570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="304" mass="33519" checksum="F054C77A1F16BDB3" modified="2019-02-13" version="1">MDKTIELKQRLPQEIYQSPPSWWGYLLILPGILLVSFLFVGMGILTYYSFLTFDSIEFIIYEFTLENWRSFLTTDAYYFIFFRTIGLSLFITILAVGLALPYAYLTIRVRSSLLRKLLLISIFVPFFTGVIVRAYGWLIILGQNGLVNSFFGIFGLGPYRLIGTEIGVIIGLLQIMIPFAIIMIAPAVQNIDRAMELAASNLGANPFQTFYHIVIPLAKPGIAGGTIVVFTITAATYAVPALIGGGRVDFIANVIYRSLFDLSNYPLAATFSVALVIVASIFVLGIFQTLGSGTLGVDTGDSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLQ0</accession>
    <name>A0A3N6LLQ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MgtC/SapB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88090">
        <property type="protein sequence ID" value="RQG88090"/>
        <property type="gene ID" value="EA462_13005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025105">
        <property type="entry name" value="DUF4010"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13194">
        <property type="entry name" value="DUF4010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DUF4010" evidence="6">
        <location>
            <begin position="184"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG88090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="417" mass="43957" checksum="7A9A070AD0E9F0CD" modified="2019-02-13" version="1">MMAVFEVPELLQQVVIAIAIGGLIGIEREKESTDKFAGLRTLALLCGAGPVMVYYAQISGYTAAVLLYLVLAAIFAFTIAYIRFTLSGDDIGLTTSVTVFFVALLGVIVGYGRFVEAAAITIIVAFLLAEKEQMVSFVDSLTYDELSDAMKVGALVFILYPILPAEPVDPYGVINLQEVLVFAIFVLMIEFSAYVSMRVFGGSKGLQVTGLLAGMANSFATAAVMARMANKSREALEAASSGIMLSVISMIIRNVGLASVIAFAIFWTIWIPALAMIAITVAIAYYLLRTSDSHDDIDVDIDSPFSFTSAAKFSAIYVAITVVAVVSQELLGDVGLLATAYTGGLISSAAVAVSAATVYNSGAASVEAAGGMVMLGIMASLSSKIVLVEIINGQMRKKAMLPMAFTGVVGLAVYFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM18</accession>
    <name>A0A3N6LM18_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="2">2.7.1.49</ecNumber>
            <ecNumber evidence="2">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiD</name>
        <name evidence="2" type="ORF">EA462_17315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.49" evidence="2"/>
    <dbReference type="EC" id="2.7.4.7" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86111">
        <property type="protein sequence ID" value="RQG86111"/>
        <property type="gene ID" value="EA462_17315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="276" mass="28205" checksum="20861BE441560277" modified="2019-02-13" version="1">MKRPAPETRPVALTIAGSDSGGGAGIQADLATMASHGVYGTSAITAATAQHTRGVESSFVLPAASIAAQIDAVVGDFDVGAAKTGMLATTEVIELVADRARGFDFPLVVDPVMVATSGDRLLEESAERAYETLFENATLVTPNADEAEVLTGVSVEDVASAQQAGEELLEFGADAALVKGGHVPGETVRDVLVQSGDRSTGVSDPPGRTFEHERIDTEATHGSGCTLAAAIAARLASGEGLESTVEGATDFLARAIEHHYDVGQGPGAVNHGVNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM30</accession>
    <name>A0A3N6LM30_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_08410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90018">
        <property type="protein sequence ID" value="RQG90018"/>
        <property type="gene ID" value="EA462_08410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="183"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG90018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="418" mass="45366" checksum="B1101B4777FD940B" modified="2019-02-13" version="1">MSSTTNPFESLQSQIDEASTYLDVNDDVIERLKHPERVLETNLTVELDDGSLERFTAFRSQFNGDRGPYKGGIRYHPQVSRDEVKALSGWMTYKTAIVDIPLGGGKGGIIVDPAEYSESELERLTRAFATELRPMIGEDRDVPAPDVNTGQREMNWIKDTYETLENTTEPGVITGKNLASGGSEGRVEATGRSTVIAAREAFDYLGKDLEGATVAVQGYGNAGWIAAKLIDEMGATVVAASDSSGGIYNPDGFDPVNAKEHKNETGSVVGYPNADEEITNEDVLTLDVDLLIPAALENAIDGDLATDVTADVISEAANGPLTPEADAILEGEDVFVIPDILANAGGVTVSYFEWVQNRQRFYWTEETVNDELEDIVVDAFDALVETIEEYDLENPRTAAYVVAIQRVADAFDEAGSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LME8</accession>
    <name>A0A3N6LME8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">pdxS</name>
        <name evidence="6" type="ORF">EA462_16330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86705">
        <property type="protein sequence ID" value="RQG86705"/>
        <property type="gene ID" value="EA462_16330"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="5">
        <location>
            <begin position="16"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="302" mass="32166" checksum="3FE9B9C7ECA7038F" modified="2019-02-13" version="1">MSDPMELESLYQGTELIKRGFAKMQKGGVIMDVVSREQARIAEDAGAVAVMALEAVPADIRKRGGVSRMADPATVREIIGEVSIPVMGKSRIGHTKEAEILEAVGVDMVDESEVLTPADNSYHIEKHEFTAPFVCGARDLGEALRRIDEGAAMIRTKGEAGTGDVNQAVHHQRTIKGAIRELEGKSAEERTAWARENDAPAELVHETAEMGRLPVVNFAAGGIATPADAALMMDHGCDGIFVGSGIFGAEDPEAMAEAIVAAVNNWNDPEVLAEITDGVGQGMKGDANVDLPKEEKIQERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMF7</accession>
    <name>A0A3N6LMF7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_11405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88987">
        <property type="protein sequence ID" value="RQG88987"/>
        <property type="gene ID" value="EA462_11405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="6">
        <location>
            <begin position="173"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="7">
        <location>
            <begin position="298"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG88987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="410" mass="46485" checksum="847304ABBD1F8FDA" modified="2019-02-13" version="1">MLGVLGGLEQLGWAASKLWNVGRYYTQEQWDETGEIPDDRELKTELKGHERYTDLHSQSSQRVLEELAEAFNGWFGKRRNGDDRARPPGYRKNGDSHPRSTVSFKAAGFKHDAQFNRVRLSKGRNLKEHRSDFILCEYQTRPDVDLTEWDIQQVRAIYKRDEWRLQFVCRTTIDPEPPGDEVGGVDLGICNFAAVSFGSESVLYPGGGLKEDEYYFTKKKAKCDDSSSREATRIDRKRTGRRTHFLHALSKAIVEECIERGVGTLVIGDLDGIREDDENGEPRNWGDHGNLDLHGWAFDRFTTLLDYKAEAEGIDVELVSERDTSKSCSACGHTDDNQRVKRGLYVCEKCNTVANADVNGAENIRQKVLPSLATDGGDRDNGWLAQPAIHLFDRSEGRFAPREQVVNREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMY1</accession>
    <name>A0A3N6LMY1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_11500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89277">
        <property type="protein sequence ID" value="RQG89277"/>
        <property type="gene ID" value="EA462_11500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="143" mass="15772" checksum="83F4D857ADEC5C48" modified="2019-02-13" version="1">MPALRDALRDLSEDVFFDLLESDETYLIVLDVPGVTADSLDLSVEADRLCIEARRAKDLPGEYRYLEENRPMFLDAELPLPDDAIGGETTASVDRGVLELTIPKRPGGGETTIDVVDRSGSRTGSDADDRDDSEDNREPTESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMY7</accession>
    <name>A0A3N6LMY7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86925">
        <property type="protein sequence ID" value="RQG86925"/>
        <property type="gene ID" value="EA462_14795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="75"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="143" mass="15936" checksum="9001BE0FF6015D65" modified="2019-02-13" version="1">MNVELPFAPVDTIIRRNAGDLRVSADASRELATRIQEHGSELAIDAAERATADGRKTLMAADFEVETVIDKDDLELPVAPVDRIARLEIDDRYRVAMDARIALADILEDYADNVARAAAILAHHADRRTIIDDDIETYFSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LN12</accession>
    <name>A0A3N6LN12_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC family peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86955">
        <property type="protein sequence ID" value="RQG86955"/>
        <property type="gene ID" value="EA462_14960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="131" mass="14312" checksum="39029A5B35DD5907" modified="2019-02-13" version="1">MSKQSTTVSEEGFSATNEVRDFETLIDATGEDAPDTLEMLLSTYATCYVPALRVGGQQRGVDELGRVEIESSGELNDDDKLESVSFDISFEADVDDETAEKIVERANELCKVHDALKTQLHAETSVETGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP24</accession>
    <name>A0A3N6LP24_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87987">
        <property type="protein sequence ID" value="RQG87987"/>
        <property type="gene ID" value="EA462_14105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="369" mass="40607" checksum="35803F3F08A0CC63" modified="2019-02-13" version="1">MDHSRDIDPERLERYRSLATEEHLDGRPETEQAYIEASIDRDDDGPAPGYDPVWYYHSTNGMFRAPHNRDLSTVDLACVGVPMDIGTPNERTGSRLGPRELRRWSQNHGPANPETGVNPFERCSVSDWGDVRFTDDPYDLSANVEELYERYVEFDDADVTPLTVGGEHTITYPILRALGRDEPLGLIHLDAHPDTRAGEYHGAGVTDANLVTNAVTEGVIDPERTIQIGVRGRVLLSNDFSHETGMRVVEATEFQDAGPQAIAEEARRVVGDGPCYVTVDTDVFDCGVMPGTTLPEPFGLTGREVRDFLRGIRGTNIVGADLVELSPPYDDTGKSGCLAAGIAFELLSLVAEARDEFSDDTGRTTWNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP78</accession>
    <name>A0A3N6LP78_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrI</name>
        <name evidence="10" type="ORF">EA462_04380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Contains catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PyrI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91233">
        <property type="protein sequence ID" value="RQG91233"/>
        <property type="gene ID" value="EA462_04380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00002">
        <property type="entry name" value="Asp_carb_tr_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="PTHR35805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00240">
        <property type="entry name" value="ATCase_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PyrI" evidence="8">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PyrI_C" evidence="9">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG91233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="156" mass="16870" checksum="4393E8D2A0FDF2B2" modified="2019-02-13" version="1">MTPVSNDHELRVSKIRHGTVIDHVRAGQALNVLAILGIDGGDGEEVSVGINVPSDRLARKDIVKVEDRELSQDEVDVLSLIAPDASINIVREYEVVEKHRVERPDAVEGVLSCPNPGCITTGGEPVTSQFEVLEDGVRCAYCGTITREEIASLIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPC3</accession>
    <name>A0A3N6LPC3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89977">
        <property type="protein sequence ID" value="RQG89977"/>
        <property type="gene ID" value="EA462_08195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="460" mass="49668" checksum="B0CF4A9641EB44DC" modified="2019-02-13" version="1">MNDLQKGTDLRRRTVLLGSGLAVAGFAGCLDDEPEGNGENDGKSDGGNDGGDENGGESDDDSEDETNDDEQTEDDGPQPPEPDFLVGSSQDADYETLQEAYDSLQSGDVIGIEPGTYTLQQSVDSAEVDGEILTRSYTYVGESPDETTIEILVPDEPSFIVQGLVHYDPEDGAPEFWNVALEIPADLEYARTEDEDAYEDGEAQINAHFCTVEGTLGGPTAAHGTVFMDDLSHEISPTDCRFHGEVGGRSIAGRECRFDGDLKSRNGYVLDSVIDGTVNLNSVLLRRCEIRRGINVNGGGRVEDCLVEPKPDSNLAIDIRSEYAATVTGSEIRGTVRSNQDGSHIDRFELNRFDVPGARYIIDGAPATDIYLNAFVGGDVRITTDTGDLASFPAEELDVYDPERELGNYYSEWDETSDADEGILGTRTLPGEDGAMDRHPLATPDVEAYAKAATEADEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPF6</accession>
    <name>A0A3N6LPF6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Potassium transporter Kef</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_08405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90017">
        <property type="protein sequence ID" value="RQG90017"/>
        <property type="gene ID" value="EA462_08405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="4">
        <location>
            <begin position="410"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="567" mass="62300" checksum="25C922EF82FFABF9" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPP1</accession>
    <name>A0A3N6LPP1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91468">
        <property type="protein sequence ID" value="RQG91468"/>
        <property type="gene ID" value="EA462_05765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="221"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="424" mass="45342" checksum="C25CC31B1EF36C40" modified="2019-02-13" version="1">MTTDDLIALRRDLHRRPEPAWREFYTTARIVDELESRFDLDGLHVGADAIADEQRMAVPDDAELDRWYVQARDAGIDEAILEQLEGGYTGAVAVLECGPGPTVGLRVDIDGLPREESNDPDHHPAAAGFRSEHEGAMHACGHDAHATIGIGVIERIANSDFSGTLKVFFQPAEEIIGGGKSMAKSEHIRDVDSLLAVHIGLDHPTGEIVAGIDGFLAVCHLEATFTGEPAHAGGHPEQGRNAVQAMATAVQNLYGIPRHNDGKTRINAGVVEGGSAANIIPEESRIVAEVRGETTELLEYVRANARRVLRSAAEMHDCDLEIDVGAEAPSATSDGELVSIVETVATETPGVKTVLERDQLGGSEDATFLMREVQRNGGTACYVGVGTDHPGGHHTSTFDVDEPSIGHAVDVLSGTIERLAREHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPU1</accession>
    <name>A0A3N6LPU1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91548">
        <property type="protein sequence ID" value="RQG91548"/>
        <property type="gene ID" value="EA462_06205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="64" mass="6454" checksum="87A4BAC15DEC0BAA" modified="2019-02-13" version="1">MFESVDTLGTIRNLGVYAIGVGLAAVGALGLADAIDFSIVLSGAFFVLGLALVVAVHEFFGGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQC7</accession>
    <name>A0A3N6LQC7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_12350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89154">
        <property type="protein sequence ID" value="RQG89154"/>
        <property type="gene ID" value="EA462_12350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="235"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="439"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="688" mass="76602" checksum="F460055465C8CD9B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRW4</accession>
    <name>A0A3N6LRW4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91197">
        <property type="protein sequence ID" value="RQG91197"/>
        <property type="gene ID" value="EA462_04190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="35"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="279" mass="30521" checksum="2E64E1C403246281" modified="2019-02-13" version="1">MAEITGSDTGNKIETITSPDGTEIAYKRTGSGPPLVLVHGADVDHRFWDVSGVRQSLAEHHTVYAMDRRGHGESEHPDEFELDREFEDIVAVVDSIDEPVHLVGESGGAFSSLEAVLRTDNVRTLTLHEPPVPGFEDAPAREGFETMVDMLDEGDRDRALATFLEGPAGATPEEVEQLRNHPIWPEYVATFIETVIPKMEAEAEADYQFDPDRFAQLTVPTLLLAASETAEWLLDATDAVADALPNARVVSIDGYGHGAVASAPDWFTSEVLVFVRESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSB4</accession>
    <name>A0A3N6LSB4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92793">
        <property type="protein sequence ID" value="RQG92793"/>
        <property type="gene ID" value="EA462_00760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="244" mass="26514" checksum="6B903D2086201226" modified="2019-02-13" version="1">MLAGDVRRSIERSIVDLVELVPLLLVAAAIVLIGVAIGNRVRPLVISTGRRIELDEKVRRTPFDALFSDDQKAVSRTFATITRYYVVIVAFFVAIEWVAFRYTASASWFFSTWAQDLLSYVPPIVVGLIVLFLGFYLASYAADQVRQSPIARGSGVSPALAGVTKGLLYFVVLVIGLETMGVDVTILHTFAQALAYGGGLAAALAIGIAFGWGGKDYVAENIDDWFERSRDVANESPVVTSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSF2</accession>
    <name>A0A3N6LSF2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_01110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92853">
        <property type="protein sequence ID" value="RQG92853"/>
        <property type="gene ID" value="EA462_01110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="164"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="372" mass="40216" checksum="F5D42DF6FCD20876" modified="2019-02-13" version="1">MTRPEPTRRGRIRIEGFDERRTSDQLETDERTATGSSDSVERLRSAGWNSTETDRNPRVDSARSRLLNFRRGRRLEDVWRRFRSSRTALLGFVIVAGLSLVTIFARPIELSAVGYTLTVQPFSLAPYDPSAQYVGPSNAGPSLAHPFGTDWAGRDVLSRVLAGGRFSLSIGALAVALALCVGVPLGAIAGYFGGWVDETIMRLVDTLYAFPFLVLAIAVVAIFGQGYWNVVAALAVTGWLSYARLLRGEVLSIVDREYVDASKALGTPHRTILVRHVIPNAIAPVIVQATLNVGTVVLAAAALGFLGLGLEAGTAEWGTMLAGGRSSLLQGHWHITVFPGLAIFLFVLGTNLVGDGLSDALDPQSEFERRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSI3</accession>
    <name>A0A3N6LSI3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_09750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90254">
        <property type="protein sequence ID" value="RQG90254"/>
        <property type="gene ID" value="EA462_09750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="301" mass="32655" checksum="AB3959B06D856FDD" modified="2019-02-13" version="1">MQALVIAAHGSHLNPNASDPTYAHADAIRETGAFDEVREAFWKEEPHFREVIRTLESESVFVVPLFISEGYFTEQVIPRELRLEEWDPALWDSNGTDASQATLEATDVGKTIHYCGPVGTHDAMTDVIVGRAETVTDDPSVGEGFGLAVVGHGTERNENSAKAIEYHAGRIRERERFDEVNALFMDEPPEVDDVTDYFESEDVVVVPLFVADGYHTQEDIPEDMGLTADYRRGWDVPAEVDGHRIWYAGAVGTEGLMADVILERAADAGADIDEAIAAVRAATTATGDGGVNSDASTGAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSJ4</accession>
    <name>A0A3N6LSJ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92918">
        <property type="protein sequence ID" value="RQG92918"/>
        <property type="gene ID" value="EA462_01470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="196" mass="21833" checksum="4579CCD9C6C07072" modified="2019-02-13" version="1">MVDPRSPDPYDDINEAVRSEWEAETTPAERVKNVIRHTYTPVTAGAVADDAQTTPKTARKHLEALAEDGFVTTTQGKRGATLYRRSNESLVTERANRLLSERSVEELTTRVAELQEEIQEYRETHGVDSPEELVVRLGNEALDNSDSDTRVDRSVVTEWQTTRRNLAFATAAVSIGKATDYIAESRSNSTQAVNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSQ4</accession>
    <name>A0A3N6LSQ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92998">
        <property type="protein sequence ID" value="RQG92998"/>
        <property type="gene ID" value="EA462_01950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="351" mass="38827" checksum="AC77EC2CBEB8C149" modified="2019-02-13" version="1">MGPTNTRRSFMKGAGGATVGITAGLAGCLFGGDDEDLVIQYNAVDGWANYSTVRDTFTDETGIDFPEDTKNSGQTLNALTNEADNPQADVAYMGISDAIVAEQEGLTEPYQPEHWDQIPDDLKHEDGEWFCNHYGTVGWAVNTEEIEDPPETWEDLLDERFEDTIALYNPESAYNGFINYVNANLAMGGSLTDFEPGIDFFQELQDRGNIAAMPDQGVTTSFFQGEVPMLMAYDFNAYEAKYLSDMDEDSVEVIVPDDSALVIPYTLNVVNDAPRRENAEALCDFQLSEQGQQLFAESFVTPARDDVSIPDDVAEMMLPDDEYGGSEAIDYEELVEHQGDIRSEFSEEIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT73</accession>
    <name>A0A3N6LT73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93228">
        <property type="protein sequence ID" value="RQG93228"/>
        <property type="gene ID" value="EA462_03270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="414" mass="44822" checksum="6FD5BEA72E46F850" modified="2019-02-13" version="1">MRRRNSNRMHRKTGRRSFLALTGATVAGTAGIAGCLSDENGTGNGNGNGNGNGDGGTDTGGNGDAGTATVADADPLASPVDGSGVSWDELGDLEGEVTVYSGRTRDQIDLVFEALEEEYDGLEIHRNWDDNDAQVNQLVQEGDATPADVFYSQDPGALGAVHDERLVQQLPEDVVDTVPESYREPGGHWTGVSGRVRSIQYNEDRLDETPFDSWDELPTDIFEYATDDRFEGIISTRPNSGTFRGFIQSMVELEGEDATREWVSGFMDQDPQLFSGGSDQAAAVERGGDDDPIIGLGNSYYAARLVNEDPDSPIRVTFTEDDPGCLFSVAGVAVTNNVDDPELVAEFTRHLVAEEGQEFMMEANGEFPVVEGVDYVGPLPNPDELNSPNFDLSSFDMELQEARELLEDEGMLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LTA0</accession>
    <name>A0A3N6LTA0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Low specificity L-threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_03410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93253">
        <property type="protein sequence ID" value="RQG93253"/>
        <property type="gene ID" value="EA462_03410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG93253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="340" mass="36315" checksum="F5FF1DCAD3FFEC0C" modified="2019-02-13" version="1">MIDLRSDTVTKPDEAMREAARDADVGDDVYGEDPTVNDLERRAATAVGTEAAMFVPTGTMGNQIAARVHTEPGQEVLAERESHVVRYELGGLAQHSGLQLRRLDGGDRGVPTAEQVADGVVEEDLHRPGTGLLCLENTHNVRGGVAITPTEIAAAADVARERDVPVHLDGARVFNAAVALDVPVTGITAHVDSVMFCLSKGLGAPVGSILAGSEPFVAQARRTRKLFGGGMRQVGLIAAPGLRALDNVTDFERDHERARRLADGLDGVDGFDVQTPETNIVLVDVSGTGLEPSVVLERLRDREVLATTVGETAIRFCTHRNVSGEDIRRALERVEAVPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUP5</accession>
    <name>A0A3N6LUP5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91294">
        <property type="protein sequence ID" value="RQG91294"/>
        <property type="gene ID" value="EA462_04720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="104" mass="11158" checksum="7FB9BDB8A449FC03" modified="2019-02-13" version="1">MSRGRGPGSEANDRGRRRPDRESGRRRREGNDRSPSRRSDSRFGGDDGRTGRRRLGVAFVVLVGLSGTTMALQGGASPSTVGLATAVGLIAGGALLWYLIWMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUU8</accession>
    <name>A0A3N6LUU8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription initiation factor IIB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91374">
        <property type="protein sequence ID" value="RQG91374"/>
        <property type="gene ID" value="EA462_05200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TFIIB" evidence="2">
        <location>
            <begin position="18"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="102" mass="11141" checksum="A72CBEC2BFB65581" modified="2019-02-13" version="1">MHSARDRIEYEPWLEELEAAADRLALSSEARSCAIDLFLADVPSNDRSKQAVLAASVYAGSLIAGDGRTQGAVAEATDVSRLSIQTRWKNLLEDAGLEPPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVJ6</accession>
    <name>A0A3N6LVJ6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">crcB</name>
        <name evidence="7" type="ORF">EA462_06705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91734">
        <property type="protein sequence ID" value="RQG91734"/>
        <property type="gene ID" value="EA462_06705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="133" mass="13847" checksum="FDD269BAF8E5F410" modified="2019-02-13" version="1">MSLAVWPSLTDVLAAFDPEPAHLVGTGGAIGAVLRYGVYRQLSSERFPWPTLAVNVIGSFVFGLAIFAGASESTIQLLGIGICGAFTTFSSFSVETIQLYERGDRSLAVANAVGNLVLSVAGIGLAWVVVTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVK6</accession>
    <name>A0A3N6LVK6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DMT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_00670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92777">
        <property type="protein sequence ID" value="RQG92777"/>
        <property type="gene ID" value="EA462_00670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="151"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="349" mass="36047" checksum="290DD2DDCDEF2B3E" modified="2019-02-13" version="1">MNSNRDILLFVALAVAWGTAFSAIEIGLETLPPLLFAALRFDVAAVVFAALVVALRTEWRPQARADWLAIVVGGVLLVGVHFGLLFVGQSYVSSAVSAIVMSLIPIVTPLIALAVLPRTRIRAPVVAGLVVGLAGIVVIAVSGGSLAGHGLGIALLFVAALSFAVGSVLIERIQGTLPVVSLQAWAMALGAFILHALSAVHPGEHVSSVTVTPATLGALAYLGVVSTGGAFFLYFVLLERVGATEISLVNYAAPIVAAVFGWAVLGESITVATVAGFALIVTGFALCKIDAVWRLLGPAIGYGPGRTPTETDDVVVGSNVYVAHAGEERHRDRRSERTGRTSNGSPCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVX8</accession>
    <name>A0A3N6LVX8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="11" type="ORF">EA462_01640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92947">
        <property type="protein sequence ID" value="RQG92947"/>
        <property type="gene ID" value="EA462_01640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="30"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG92947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="433" mass="48036" checksum="813A2552FA16C924" modified="2019-02-13" version="1">MYDRIKGFRDVYPAEMAAWRETIDTLEDTARQYGFREISTPALERAELWTDKSGDDIVDELYAFEDQGGRHVTLTPELTPTVARMVVAKQQELSKPIKWFSTRPFWRYEQVQQGRQREFYQTNVDIFGSSEPEADAEILAWAADALTGLDLTEDHFEFRISHRDILGGVLESYETDVDVDDAIRAVDKSDKLSTAEYHDLLIGAGLSADQAAEFADLVATGDLEAVRSFAGTERVRDAVDNLQAVLGAVEDFGAREHCTISLETARGLDYYTGVVFECFDSAGEVSRSIFGGGRYDDMIESFGGQPTPAVGVAPGHATLPLLLQRAGVWPDERISTDYYVLQIGDTRADAARIVRELRERGHVVETDIAGRSFGAQLNYADSINAETVVIVGEQDLENDEVTVKDMASGDQTQVPVSSFPGDRTRPTIADFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXE4</accession>
    <name>A0A3N6LXE4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_16370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86711">
        <property type="protein sequence ID" value="RQG86711"/>
        <property type="gene ID" value="EA462_16370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="323" mass="34667" checksum="EB52C23C45B87A02" modified="2019-02-13" version="1">MNQIQEFVKSVMNQVQPYSKELIIISALISAVLPFIVTSSTLFDLKIMLIFAILAFAVILPIGYTGQLILSQGAFFGIGAYSFVLLVSRGVPSIVGVVVAVTLTALVAYLLGKPATRAHGIYLGIITLAFNMLFVIALEIFSNVTGGNVGLTSPDLLPEVVTGALPEDVLLYYIVLVTYIGVFLFFSRILDSEIGSAFLAIKEDTVVAESIGIDSHRYRLHSFTLSGAVCGLAGGLFAPVNGFVSPPVFDLDTTIEIILAGVAGGLSIPFGSIFGASIVVLLPEYLRAIEQYRLIVYGVLIILILAYLPQGVGGWLQEQWRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXV8</accession>
    <name>A0A3N6LXV8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86911">
        <property type="protein sequence ID" value="RQG86911"/>
        <property type="gene ID" value="EA462_14725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="335" mass="36954" checksum="67686F508F7F8984" modified="2019-02-13" version="1">MTTAYVALPDRLCRYERDERSGDWTFQTQLEGRRLECLAADGTEPNRVFAGTFDHGLFGSLDGGETFDRLETPFDSEAVTALAISPHDPETIYAGTEPSRVYRTTDGGDSWVRLEGITDLPSEDEWYFPPRPHTHHVRWLTVDPFDPDRLYVGIEAGAFVRSEDGGETWVERPEGSRRDNHSLATHPDREGLVYSAAGDGFAVSSDGGEHWTHPQSGLEHRYCWSVVADPGDPETVLVSAASGASTAHSADTADSHVYRRHGDEDWQRLEDRGLPTGGGVVRAVFETTGAAGVVYAVTNGGLFRSTNFGDAWTRIPVEWPNEFTELTPRGLVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY81</accession>
    <name>A0A3N6LY81_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">50S ribosomal protein L37ae</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87071">
        <property type="protein sequence ID" value="RQG87071"/>
        <property type="gene ID" value="EA462_15680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_L37ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="88" mass="9450" checksum="4F8AC4021E119960" modified="2019-02-13" version="1">MADKGTVGSAGRFGARYGRVARRRISEIEDDMNNAEVDGDDVSRVGTGIWKNDETGEVFTGGAYRPKTPAGRTVTRSIRAALADDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYK8</accession>
    <name>A0A3N6LYK8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_01680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92954">
        <property type="protein sequence ID" value="RQG92954"/>
        <property type="gene ID" value="EA462_01680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG92954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="391" mass="40727" checksum="B4F49DCBEC99EA61" modified="2019-02-13" version="1">MTEVLLIVGLIVAVFVGYNIGGATTGPAFGPAVGANVITKLMAAALMSVFFFLGAVTIGPNVVTTLGDELVHTTDIFTLRANVAVLFFIGSALFVGNYAGVPASTSMTAVGAIAALGLATGQLNLAVLGEIVIWWIVAPIIGFWVAGIVGRYFYPRINAWIAIEASDGDRKMITVDRSGAIPRLRFGDDANRREITGALIVVGIGCLMGFSSGTSNIANAIAPIYGTGEIEMMPLILLGSIAVAVGCFTIARRTLDTLGNDITNLPLTAAIVVAVISSTLVIGLSFIGIPASFVVIATMSIIGLGWGRATRTTTIPDAARGEETRVSVGALTAEEEGEEPPEIGTEDPTDIPKASDLFDPSTTARVILMQNVVPIISTVGAFFTFRFVPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYN8</accession>
    <name>A0A3N6LYN8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92984">
        <property type="protein sequence ID" value="RQG92984"/>
        <property type="gene ID" value="EA462_01855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="218" mass="23503" checksum="DE66C547C142A523" modified="2019-02-13" version="1">MYRDLTHPIRTGIQIYPGDPEVSVSPAATVSEDGVAVQEICCGSHTGTHIDAPSHTEPDGTDLDDRPIGEYVFDARFVDIAPCSRRERIEPDAVVPALADDDESPDLLVVRTGFDEHWNTDRYLEHPYLAPETAVALRELGCGVALDTLNPDPTPTANAADDEPDGFPAHRALLGAELPIIENLTSLAGLPDRFRLYAFPLAVQNADGSPIRAVAAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ18</accession>
    <name>A0A3N6LZ18_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatininase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_02715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93134">
        <property type="protein sequence ID" value="RQG93134"/>
        <property type="gene ID" value="EA462_02715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="245" mass="26376" checksum="6E3720D1AF64CBEF" modified="2019-02-13" version="1">MDLTEATWTDVQELETDLAVLPVGSTEQHGPHAPLGTDVLTARAVADAGVDRFDRAVVRAPAIPVGIAAEHRQFSGTMWVSPETFRSYVRESIESLAHHGFDRVVIVNGHGGNVDALREVGTTLSRDGDAYAVPFTWFEAVGTHSSRMGHGGPLETALLRHCEPDLVREDRIEAARDGAADGWGEWVSRANLAYDSAEFTENGVVGDPGDGTASLGDELLERAGKALARLLEAVAERDLSRPDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ42</accession>
    <name>A0A3N6LZ42_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87993">
        <property type="protein sequence ID" value="RQG87993"/>
        <property type="gene ID" value="EA462_14140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="79"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="280" mass="30825" checksum="13A2D57CA8D8AEED" modified="2019-02-13" version="1">MNPLTALLHRIEISDRTADRLLAGHTILLFVFIYVPILVVALLSFTPQEVPTFPMPGISLEWYGELVPPNHNEQLVDALFRSVAIGILSAIGAGIVGTIAAFGLVRYEFEHRLLSRETLNTVFLLPLVVPWIVTGIAVLTLYDMIGIRGTFFSVVLGHVLITIPFVVIIVSSQLYGLDRSIEEAAKNLGATELRTFYEITLPILAPSIIAGMLFAFTISFDNFTQTFFWATTGTETLPIVIYSMIRTGIDPSVNAIGTVIVLFSLSVAFLGERLSKRILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ47</accession>
    <name>A0A3N6LZ47_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Baseplate protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88003">
        <property type="protein sequence ID" value="RQG88003"/>
        <property type="gene ID" value="EA462_14190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="2">
        <location>
            <begin position="32"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="135" mass="15114" checksum="2A9A8116728A063A" modified="2019-02-13" version="1">MVRDTHPEDPFPGSGWQFPVSTDHRGDIALSSDNESVEEAIRIIVGTAKGERVMRPEFGCDIHDHVFDSINGATMSLAEESVREALIAWEPRIDVRDVDASADPDHPNTLLITIRYVVRSTNSEGNMVYPFYINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZU0</accession>
    <name>A0A3N6LZU0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88830">
        <property type="protein sequence ID" value="RQG88830"/>
        <property type="gene ID" value="EA462_10535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="153" mass="15491" checksum="77967F729F37FDD2" modified="2019-02-13" version="1">MIGRIAIGLILIGGIGFILSTAGYSAFTGGREAIVQVAPAAEATIGIEDEYNGTPIENGEGEIILDLKNNSPEPVELDVEIEDVGGVDPESIEVVQHPSELQPNGQGSVTVGCSGRAPGQGAANVTFCVQASGTSTAIEASKVAQGLNIDCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M063</accession>
    <name>A0A3N6M063_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87914">
        <property type="protein sequence ID" value="RQG87914"/>
        <property type="gene ID" value="EA462_13710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="140"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="297" mass="33250" checksum="B8A779B245EE9C03" modified="2019-02-13" version="1">MVGQQRLEHAELGVTDLDDAVSFYTDVMGMIEIERSSDTVYLGCGLDENFDIAVTEGGTGTRHFAVRVDNSDELARYERNLDEEGVKTKRVDGEEPNQVEGIRFSMPMGVDMELVLVEDMGYRHSDEARVPGRSSVCPVDIDHITLGSLNPQENVEFLEDVVGFNVSEVLLKEDESWRGAFTRWGVHHHDVAVLGRPDGTEYNLRHIAWTMSSIDHMKAFIDNLAQAGYELEVTIHRHYAGDNLAAYFWEPGGNRFEICAEMATLDPNTPTNYCEPGEGYTAWGGVHPPESYRKDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0J9</accession>
    <name>A0A3N6M0J9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88084">
        <property type="protein sequence ID" value="RQG88084"/>
        <property type="gene ID" value="EA462_14645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="145" mass="16270" checksum="FA046387BF49A473" modified="2019-02-13" version="1">MSDRYVFDTEAIIAYLYDEPGRSVVEEYLRDVRDGTVEGVLAETNAGEVLYLVARFEGIDDKPTADSLRTADRDLRALERWGIQIERADWRLAAEVKADGHISFADAHGVALAHKRDTTLIAGADDDFETLPIDVDVVRFREDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1G7</accession>
    <name>A0A3N6M1G7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_11090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88931">
        <property type="protein sequence ID" value="RQG88931"/>
        <property type="gene ID" value="EA462_11090"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02166">
        <property type="entry name" value="NMNAT_Archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01527">
        <property type="entry name" value="arch_NMN_Atrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="6">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG88931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="172" mass="19388" checksum="FD87D4D360BDF22B" modified="2019-02-13" version="1">MTRGFYIGRFQPFHNGHRNMVARIADDVDELVLGIGSADDSHTVRNPFTAGERIMMITKSLVDTDLVTYAVPIEDLERNSVWVSHVQSMSPDFDVAYSNNPLVIQLFREAGIEIRQSPMFNRDVLEGTEVRERMITDGDWQSLVPEAVVEVVDEIDGTERIQMISDTDSNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1L4</accession>
    <name>A0A3N6M1L4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88991">
        <property type="protein sequence ID" value="RQG88991"/>
        <property type="gene ID" value="EA462_11425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="77" mass="8510" checksum="59A0783D731B2696" modified="2019-02-13" version="1">MSTATTPTLTAKQQQILSYLRNNAATKTYFKSRLIGKELGMTAKEVGSNITALQEGDHGVEIEKWGYSSSTTWKVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M204</accession>
    <name>A0A3N6M204_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89131">
        <property type="protein sequence ID" value="RQG89131"/>
        <property type="gene ID" value="EA462_12220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="81" mass="9222" checksum="4D6E62C3B023B4E9" modified="2019-02-13" version="1">MSMSTTAQPSTESKEHRLKRYLRDRAEDGELYFKGKFIADEVGMSPKEIGALMVKLSESATELEIEKWSYTSATTWRVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M220</accession>
    <name>A0A3N6M220_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF502 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89151">
        <property type="protein sequence ID" value="RQG89151"/>
        <property type="gene ID" value="EA462_12330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="210" mass="23106" checksum="C5C188362C98B647" modified="2019-02-13" version="1">MGTVRKRLKRWFVNGVAITIPLVVTVLVLLVVIDFVLGVLSPVIEGLIYAWPNEPPRIVVQLASLLSIVAFFVLVGLVAEYTPGRYLSKRVHRTMETIPGVRTIYESVRRAANLLVDDDTDQFQEVKLVEFPHENAYMLGFLTADTPPKIEANTGCGDMVTIMVPLGPNPTTNGFVMHISSENVYDIDITVEEAVRSIATLGVAADDIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4B6</accession>
    <name>A0A3N6M4B6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90071">
        <property type="protein sequence ID" value="RQG90071"/>
        <property type="gene ID" value="EA462_08710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="73" mass="8353" checksum="20321BD21453AEA4" modified="2019-02-13" version="1">MKPRLVRGFSGNDLQQSLRDRFETVTARRIAGRTRNGLSESHNPLSREPRGTKPVVLEPSTRWLSDHPIETDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4Q8</accession>
    <name>A0A3N6M4Q8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EA462_09560</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90221">
        <property type="protein sequence ID" value="RQG90221"/>
        <property type="gene ID" value="EA462_09560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="14">
        <location>
            <begin position="38"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="15">
        <location>
            <begin position="225"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="420"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="649"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RQG90221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="890" mass="101476" checksum="853ABBF670978E1F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M573</accession>
    <name>A0A3N6M573_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87849">
        <property type="protein sequence ID" value="RQG87849"/>
        <property type="gene ID" value="EA462_13365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="125" mass="13566" checksum="ED46A736E843A415" modified="2019-02-13" version="1">MNGEVGLEEWLDAVALGDGYYHRCSSGHSTLPPGDRCPECGSGLERRPLPSRGELRSYTVSNVSTPEYDDQTPLGIGIATFGSVDVTARLPAVESGRLETGTTVRLSVEERRSDGSRIPVFRLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5D7</accession>
    <name>A0A3N6M5D7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91230">
        <property type="protein sequence ID" value="RQG91230"/>
        <property type="gene ID" value="EA462_04365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="330" mass="36071" checksum="6004D21BE1F77C33" modified="2019-02-13" version="1">MTEEQEAELEEQADDVDEEVDETADEADGLQNGDFVEIEYTAYTVEGEQLVDTTDPDVAEEEGVDAQGQEFKPRTISLGEGHIFEGVEEALTGSEAGDSGTVTIDSEDAFGEYDADNVETVSAEKIAEDDRHPGANVQIDGRQGYISTIIGGRARVDFNHPLAGEDVEYEYEIVDVVDDREQQAAGLFEMYLGLEPELWIETDEVEEEVPVEPDEDGESSEEPDEGDEPAEPEFETEVVEKETLYLEATPQMTMDQQWMMGKQQIGQDIIEKIGVDRVIVQEVIDGMGGMGMPGMMGGMGGMGGGDIEEALEDADVDADEIVEELEGAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5P2</accession>
    <name>A0A3N6M5P2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="2">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">coaD</name>
        <name evidence="4" type="ORF">EA462_14620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88079">
        <property type="protein sequence ID" value="RQG88079"/>
        <property type="gene ID" value="EA462_14620"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00647">
        <property type="entry name" value="PPAT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023540">
        <property type="entry name" value="PPAT_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="175" mass="19099" checksum="B8088F56895A70E0" modified="2019-02-13" version="1">MNSGKRIAILGGTFTPVHDGHRALLHKTFQTASHDGSGDGHVIVALTSTPLARRTRSDPTHSELLGPFEQRCDSLETEIEQLSDAYTASFEIIKLEDTHGPAVSREDIDVLVVSPEGKAQHRAHNINEQRVSNGLSPIEIHTAPFVIADDGVRISSTRIRNGEIDAHGRLLEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5S9</accession>
    <name>A0A3N6M5S9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91390">
        <property type="protein sequence ID" value="RQG91390"/>
        <property type="gene ID" value="EA462_05300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="114" mass="12619" checksum="A78642FD924CE1B3" modified="2019-02-13" version="1">MLIVRGSAGGTELTGTLYERGEQAPSFRGAPDEDAAYVWVCDEFYEVDSGGTTQLVDGREVHLAFESPMPRGFDTRPQAIECAKEHVRTQFARIGMDPADVEFDVEKSEIDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6B2</accession>
    <name>A0A3N6M6B2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88826">
        <property type="protein sequence ID" value="RQG88826"/>
        <property type="gene ID" value="EA462_10515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035185">
        <property type="entry name" value="DUF5305"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17231">
        <property type="entry name" value="DUF5305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="384" mass="41716" checksum="DD4CD13542D99F67" modified="2019-02-13" version="1">MNAAFIRLRAVAGDWFVFVVIALLALSLLGGWIAYSGVASEPDTGDGPTSAQWSPVATFDHSAEVDRDTEVFEAGEVLSDRSAYFTTVTPELDGEFAYRYEAERGDAEVGISLERQLRSVSDDDEYWSTNDPIDETAAESVGPGEVITTPFSVDVPAMMNDTEQIESSLEASPGTVEMVIVAHVTMEGTIDGDPVTVTESYELLIEQDDETYSLDTPGIDHHDTEQAPVTETQSARGPGSTLMGLVLALVSITALGVVTVQKVNGTLSPSERELARFRREHERASFDEWISTGTVPEKVYDRARIDLNSLEDLVDVAVDSDQRVIENADDEGTYYVLDDPVYVYDRMDGAEPVGLDDDGSDLSDTDADDSEPRSDDESTPPGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6Y8</accession>
    <name>A0A3N6M6Y8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91091">
        <property type="protein sequence ID" value="RQG91091"/>
        <property type="gene ID" value="EA462_03575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="104" mass="11034" checksum="D3135C07DF685846" modified="2019-02-13" version="1">MTVVALLSVAPVIEDSMASDVADAVDALEAYDVEYETNPMGTVIEADDADELFSAAQAAHEAVDGDRVSTFLKIDDKRTVDTSAAEKVEAVEDRLGRAATSDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7G2</accession>
    <name>A0A3N6M7G2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91281">
        <property type="protein sequence ID" value="RQG91281"/>
        <property type="gene ID" value="EA462_04650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="114" mass="12376" checksum="FA57B557A79E158C" modified="2019-02-13" version="1">MARDGPFDSISLTDQLVLLGIVELHRSEGAPVQTPELRRVCDGRLVDANAELVGTLTEADVMRSLYRLEDEGFVTEIDDGGGSPTGKGRPAYELAHRPEAVDVRLDDRLTADGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9K1</accession>
    <name>A0A3N6M9K1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92960">
        <property type="protein sequence ID" value="RQG92960"/>
        <property type="gene ID" value="EA462_01720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="248" mass="26143" checksum="E65BFB3CE4DC50C9" modified="2019-02-13" version="1">MRGLRSCDFCDGDAAGTFEAVPAELEPAEDERRRVVLCRDCKGRLETVLEPLLARLGVDDDETAAGSTANEDAGASTAGSEPASTGDSRTGITFEREAGAAAEDEPAGKREGADDPGAGEAEQTGIMTPESEEAGSGESDDAGSDSDPAPEPSTRDERATGSDSSARTESETAVDADSSGDDGRLRAPQTYAKTIRLLRNREFPMERTAVEELAAGAYDLETREAEAIVDHALERDEFSERGGTLYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MAG1</accession>
    <name>A0A3N6MAG1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93330">
        <property type="protein sequence ID" value="RQG93330"/>
        <property type="gene ID" value="EA462_03370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="134" mass="14731" checksum="56AC42BA54B39368" modified="2019-02-13" version="1">MRALLIAFGLLETVAPERIIEPCERLSFENPETGQLRPWTIPMARLEGVVFVSLLVRGGKRVRRLRTPIAAFGIVMALLPQTVVSVALEAAYENADELEVRRWVVPATRLLGACYVLAALLAGRVNAPEDGHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBS3</accession>
    <name>A0A3N6MBS3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">(4Fe-4S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_03725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91116">
        <property type="protein sequence ID" value="RQG91116"/>
        <property type="gene ID" value="EA462_03725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="745" mass="81910" checksum="EA06270CDCCBE02A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCE1</accession>
    <name>A0A3N6MCE1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_02865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93161">
        <property type="protein sequence ID" value="RQG93161"/>
        <property type="gene ID" value="EA462_02865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="31"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG93161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="414" mass="45864" checksum="80B460CFF05AA6CE" modified="2019-02-13" version="1">MSQQNLESLDVEAIRSEFPILEREFDGQQVVYLDNAATTQTPDAVVDAMSDYYRESNANIHRGIHHLSQEASEAYEVAHDRVAEFIGAEGREEVIFTKNTTESENLVAYAWGLNELQAGDRIVLTEMEHHASLVTWQQIGKRTGADVEYIRIDEDGRLDVDHARELIDDDAAIVSAVHVSNTLGTVNPVSELVDIAHEHDALAFIDGAQAVPNRPVDVEAIDADFYAFSGHKMAGPTGIGVLYGKEHLLEAMEPYLYGGGMIRKVTFEETTWGDLPWKFEPGTPPIAEAVGLHAAIDWLEEIGMDRIRSHEEEIARYAYERLDAEGDVEIYGPEPGPDRGGLVSFNLESVHAHDLTSIMNDHTVAVRAGDHCTQPLHDKLGVPASTRASFYVYNTREEVDTLVAALDDARQLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCH9</accession>
    <name>A0A3N6MCH9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91436">
        <property type="protein sequence ID" value="RQG91436"/>
        <property type="gene ID" value="EA462_05555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="174" mass="18282" checksum="3E0C87C641B21AEF" modified="2019-02-13" version="1">MSDDTNPSGDSRRSVMKKGALAATALAVGTGATATTTAAQEEDGEVVVSGHDYYPDTDFDVLAEFESGTRDDILESDNLEGEFDDVGDWDVYAVSFDVGSGGILGYFMVDEGDADISAGDTGSMTGTASFRNAEANLLEVDVTTEAAEDDPEDDEADAEDDEADNDESEDDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCK0</accession>
    <name>A0A3N6MCK0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_03235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93221">
        <property type="protein sequence ID" value="RQG93221"/>
        <property type="gene ID" value="EA462_03235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="86"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="6">
        <location>
            <begin position="487"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG93221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="591" mass="64969" checksum="658896DF5E2A136A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCP8</accession>
    <name>A0A3N6MCP8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93281">
        <property type="protein sequence ID" value="RQG93281"/>
        <property type="gene ID" value="EA462_00700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="69" mass="7575" checksum="35905ADBD992F4CA" modified="2019-02-13" version="1">MTDDATLSDFATGRSDEDTDERRDADGTDGVSSLSTYAWGEYVCSRCDGAAERVWRDDGAVVCPDCKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MD52</accession>
    <name>A0A3N6MD52_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antibiotic ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91706">
        <property type="protein sequence ID" value="RQG91706"/>
        <property type="gene ID" value="EA462_04895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="402" mass="45704" checksum="AF4752A22370DE11" modified="2019-02-13" version="1">MTTPLERDQQSTLRLCTDVLSYASERDYTGWDYADGLSSAYLDRLPVESKLVNLGVQEVIKRAPINLRPIFAVEQRRNYKGAALFALANLDVYELTGEKRYAREARSLLEWLLETQNEWCTGFGGGGHRHPLQDLSSDGASTPGEVSGVVSTSYAVRALLCGANALAEPRYADVARTASQFVFEDLAYTEIDEGARINYTASRGGSSERDSYTLNANALGARLLLDLYDDSGERRLLEAATAILDYVTSKQTALGGWMYTDPPTASHLSMDNFHNGFIVESLVRHHDVTDEDRYDATLERALEFYRHRLFDDDGAPRWDESSSYPRDIHAAAQGIVVFSELDDIAFARRIIDWTRDALYAGDGQFYYQQRRWYTKRFTLMRWCQAWMAYALSRHLWRIRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFT4</accession>
    <name>A0A3N6MFT4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alanine--glyoxylate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92776">
        <property type="protein sequence ID" value="RQG92776"/>
        <property type="gene ID" value="EA462_00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="36"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="370" mass="41649" checksum="6571E520CDE2FBC7" modified="2019-02-13" version="1">MTNKREYKDDYPDKTLYIPGPTEVREDVIEAMCEPMFGHRMDRMTDLYTTVVEDTKEFLGTENDVVVLTGSGTGFMESSILNLVDEDVLCTTCGSFSERQADIADRLGKRVDTVAYEWGQAVKPDDVREALEDGEREYDAVTCVMNESSTGVRNPVEEIGDVVAEYPDTYFIVDAVSALGGDYVDIDAHGIDVIFTSVQKAFAMPPGLAVCVVSEDAYERELESDSASWYGGFQRTIDYYDRKGQTHSTPAIPVMLAYRTQMKHMLEEGHDARDRRHREMAEYTREWARKHFEMFPEEGYESRTVACIENTRGIDVAETIENVSEEYDMVFSNGYGSALGEKTFRIGHMGEHDVESIEALTDAIEDVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MQK3</accession>
    <name>A0A3N6MQK3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86099">
        <property type="protein sequence ID" value="RQG86099"/>
        <property type="gene ID" value="EA462_17245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="68" mass="6946" checksum="7445240AD900B68A" modified="2019-02-13" version="1">MTLASLLVSSIVPFDPTIAVAAVASVMLTVFVAFMAFLALAPLVSSTWTEQLDASQSGGSALEANEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MQQ2</accession>
    <name>A0A3N6MQQ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF447 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86149">
        <property type="protein sequence ID" value="RQG86149"/>
        <property type="gene ID" value="EA462_16895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007386">
        <property type="entry name" value="DUF447"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04289">
        <property type="entry name" value="DUF447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="206" mass="22675" checksum="6334C91C87354BF8" modified="2019-02-13" version="1">MTDRPPSKSSDESVPDSEPSAGWPVSLTGVTETVVATLGPNDRWNVAALGLFAGDPVTARTWGNTRTRRNFHRRGAGYVQFVDDPVVFTDAALSIFEVGEPVLDDATAWVRVSVSRMSTGADDGTDWEEWELEPVDSAVRSTTVPTIGRGFNAVVEATVAASRLEVDSYDEDELRRRLEYYAAVVDRAGDSRDRAALERVREHSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSY5</accession>
    <name>A0A3N6MSY5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAP transporter fused permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87885">
        <property type="protein sequence ID" value="RQG87885"/>
        <property type="gene ID" value="EA462_13560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011853">
        <property type="entry name" value="TRAP_DctM-Dct_fused"/>
    </dbReference>
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        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
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    </feature>
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        <location>
            <begin position="75"/>
            <end position="94"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
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        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="178"/>
            <end position="200"/>
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            <end position="297"/>
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            <end position="325"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="373"/>
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        <location>
            <begin position="133"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="643" mass="68937" checksum="5A996667E036F1A5" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MT34</accession>
    <name>A0A3N6MT34_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium:solute symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_13820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87935">
        <property type="protein sequence ID" value="RQG87935"/>
        <property type="gene ID" value="EA462_13820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
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            <end position="210"/>
        </location>
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        </location>
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            <end position="301"/>
        </location>
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        </location>
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        </location>
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        <location>
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            <end position="419"/>
        </location>
    </feature>
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        <location>
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            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="494" mass="53953" checksum="5110B4574599C118" modified="2019-02-13" version="1">MVSTENVVVLAITVAYLLVVLGVGTIAARATGSSREDFLMADRSFGTVVLLFALFATNMTAVVMIGAPGLAYGTGAGALGFFVALFAFIFPVLLMTFGYRIWIVGKRFGHITPGQIANHRWEAKYLGLVFMLMFTIWTIPYILVGVQGGGIVFEALTEGLVPYWLGALTVIVVVGLYVYPGGMRGTGWTNTFQGMVFLVVLLGLFAYIGLRLGGFSSATQSVGEINDGALLDRAGIPPYAPRMWFSQGIIVAIGGFMFPHLVIRYMTARSVTTLRQTSLLYPIAIVLAWVPAVMIGFWGIAAIPDIDNPDFILPTMVFEFMPWWVIGIALAGILAAMMSSIDGQVLTMSTFFTEDVVSEFFEGVTDKQAVWYARVFLVVIFGLAYVGALLTTDTIVDTATFAFAGYGMMFIPLAAAFYWRWSTKEAVYVGLIYGFAGLWLFEFGPLPESITMGFHPFVPLLVTQFILMAIVSAVTQSPSEERIEEYESALEGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUN6</accession>
    <name>A0A3N6MUN6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="8">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">argS</name>
        <name evidence="12" type="ORF">EA462_12120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89112">
        <property type="protein sequence ID" value="RQG89112"/>
        <property type="gene ID" value="EA462_12120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="10">
        <location>
            <begin position="468"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG89112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="609" mass="68264" checksum="B483F0858135DD0E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWD8</accession>
    <name>A0A3N6MWD8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89792">
        <property type="protein sequence ID" value="RQG89792"/>
        <property type="gene ID" value="EA462_07170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="167" mass="17553" checksum="56549D8DB9B82B15" modified="2019-02-13" version="1">MSLAGETRRAIEDHPFLVTALRAGVVNYTAAARFLEIDGETDAIATALRRYAEELPAYETRPRDARVRMESGIGPVDPADDTAFVSVAGAALGSGGDDLTAILATGDVDALALAGVLRRLALEEIEPITAGVSDDTLIVVVDRLKGANALRAVENALEKIPTPERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWJ3</accession>
    <name>A0A3N6MWJ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Gas vesicle protein GvpN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gvpN</name>
        <name evidence="10" type="ORF">EA462_07500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
            <location evidence="1">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CbbQ/NirQ/NorQ/GpvN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89852">
        <property type="protein sequence ID" value="RQG89852"/>
        <property type="gene ID" value="EA462_07500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013462">
        <property type="entry name" value="Gas-vesicle_GvpN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02640">
        <property type="entry name" value="gas_vesic_GvpN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="80"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG89852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="343" mass="37577" checksum="563DF735E98E8A24" modified="2019-02-13" version="1">MVDGSSRKRTVRGRKIRADRERKESRRARKKLARTASKVTASERTGDRPLESPDEVRPEPFVETDAVVEVRDRIDGWLEAAQPVHLIGPTGCGKTALALSAAAQRGRPVVWLNGDDAVDTAALVGAHAGGERYEEHDRFVGGVNKKTQIVRERWVDNPLSVAVGEGATLVYNEFSRSNPAAHNVLLSVFEEGVLERPGKRGEDRTIDVHPEFRAIVTSNDVEYAGVHRQQDALLDRFVGVHVGYYDGETEGEIVRAHVDLSDESVEAVVETTRTLREELEIVVGTRAAITAAKGLAVFDDDDDGGQFDDDLLAEVFTDVLSPKTASEDAESIDELRSTITEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWS0</accession>
    <name>A0A3N6MWS0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_07945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89932">
        <property type="protein sequence ID" value="RQG89932"/>
        <property type="gene ID" value="EA462_07945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="262" mass="28232" checksum="E365AD55BA93B216" modified="2019-02-13" version="1">MIPIDDSPIVRDGKSLILAMDHGLEHGPVDFEDVPGKLDPAAVFETATHDAVTAMAVQKGIAEGYYPSYEDDVNLLAKINGTSNLWMGEPDSAVNWSVEYAAELGADAVGFTVYGGSNHEIEMVEEFRDVQESARDHDLPVVMWSYPRGQGLKNDTKPSTISYASRLALELGADIAKVKYPGSRDAMAHAVDCAGDMKVVMSGGSKTSDYEFLSTVETVMDAGANGLAVGRNVWQREDPTPLLDALEKVIYEGETADAALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXP4</accession>
    <name>A0A3N6MXP4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90292">
        <property type="protein sequence ID" value="RQG90292"/>
        <property type="gene ID" value="EA462_09955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="419" mass="46054" checksum="4C0B95D87AE13C15" modified="2019-02-13" version="1">MRLDVNALGTFHRMAREGAGLAAGRLTHMTGVETRVGVTKLNFMRRREIRRDFAESETNVGVRVELSGAIEGYSLIVFDRDNVIRIVETLLEEAEPDSDLDIDPGEFSRMEKSATTEVGHIMNSGFIDGWADVLETVIDVSTPEFVEGESAALLFDDVAEAPTDDDLALLFQSTIEAVDTEISFSHYLFPKRSSMARLLERLRTSDGIEYDKLDGFDRMAERGAEEIAKTATTLTGIETSVEIRRLNFVSLETIPEQVPPEKLVSVAFEFEGVPSGYLLFLFDEESAREIVDAMVPASIDEDGFGEMGTSAITELGNIMASGFLDGWANVLDTTIDHSPPEFIHDFGAAAVDPVIVKLGADQEFAFVFDTAVVADGREFGCEVYAIADESDLERALNDLDVDRIEGTPTTAEFQEVDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0E3</accession>
    <name>A0A3N6N0E3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein translocase subunit SecY</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein transport protein SEC61 subunit alpha homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">secY</name>
        <name evidence="15" type="ORF">EA462_05140</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91362">
        <property type="protein sequence ID" value="RQG91362"/>
        <property type="gene ID" value="EA462_05140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Plug_translocon" evidence="14">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RQG91362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="487" mass="53468" checksum="19F82B61B4F12B70" modified="2019-02-13" version="1">MGWKEAAEPVLTRMPAVQRPQKHVPFKRKLAWTAGILVLYFFLTNIGLLGMEAGQGDDLFGEFRAVLAGEHGSLMQVGIGPIVTASIVMQLLGGANLLGLDTDDPRDQVLYQGLQKLLVILMTALTALPMVFAGGFLPAQPTLTLGGFSFDQTQVQALMFLQIFIGGVLILYMDEVVSKWGVGSGIGLFIIAGVSQRLVTGFIQPTEGGFFYDWYLILTGQVNIGSIVAGDGLYTLLLQEGHIIALFTTLLIFGIVVYAESVRVEIPLSHSRVKGARGRFPVKLIYASVLPMILVRALQANIQFIGQIMERQWADMPAWLGQYGPQGQPVSGFFYYTAPIYSPEDWMWWTGEVAQDAWMVMIRVSVDLTFMVIGGAIFAIFWVETTNMGPEATAQQIQNSGMQIPGFRQNTGVIEKVMERYIPQVTVIGGALVGLLAVWANMLGTIGAVTGTGLLLAVSITYKLYEEIAEEQMMEMHPMMRQMFGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N149</accession>
    <name>A0A3N6N149_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="10" type="ORF">EA462_06925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the protein translocation apparatus. Forms a complex with SecD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91672">
        <property type="protein sequence ID" value="RQG91672"/>
        <property type="gene ID" value="EA462_06925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_A">
        <property type="entry name" value="SecF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024921">
        <property type="entry name" value="SecF_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG91672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="298" mass="31674" checksum="2534E1A6C64AA651" modified="2019-02-13" version="1">MGYFDVPEIEYSRYSNRQLAAVPLAILAVALLVLSGSFLVTGAPVQLGMDFAGGAELTVQTTSSEAEIQETFDIEPDSVQAIQAPGVDNQYTVQFAGVEDRDAIQALSTQAETNLEADGDAAIVQSESTVSASFAEQTQQTALLGIAVAFLGMSVLAFVLFRTFVPSIAIVASAFSDIMIPLAFMAVAGIQLSLGTVAALLMLIGYSVDSDILLNNHILRRSGDFYESTHRATRTGITMTVTSMAAMLVMGIAATLFGVELLASIGIVLFVGLAADLMNTYLLNVSLLRWYKFEGVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3I8</accession>
    <name>A0A3N6N3I8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92682">
        <property type="protein sequence ID" value="RQG92682"/>
        <property type="gene ID" value="EA462_00140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="67" mass="7530" checksum="28C5C049DBE89E90" modified="2019-02-13" version="1">MTLLVGTDEGLYRAEGVPFDRSELEKILDRVMVTAVETWEHTGGVFAANVNRIEAIRTAIDIIHHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N485</accession>
    <name>A0A3N6N485_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_01845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92982">
        <property type="protein sequence ID" value="RQG92982"/>
        <property type="gene ID" value="EA462_01845"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="5">
        <location>
            <begin position="3"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="6">
        <location>
            <begin position="105"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PGDH_inter" evidence="7">
        <location>
            <begin position="322"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="528" mass="55644" checksum="81BA8DA51A718838" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4P9</accession>
    <name>A0A3N6N4P9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_02870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93162">
        <property type="protein sequence ID" value="RQG93162"/>
        <property type="gene ID" value="EA462_02870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026469">
        <property type="entry name" value="Peripla_PGF_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04281">
        <property type="entry name" value="peripla_PGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="66"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="403" mass="42312" checksum="F8A7A4C0B65B2873" modified="2019-02-13" version="1">MSTVRICFVALLVAAIAVSPVAAVADAGGESLHSSAAADASTECSFPLTETDDTGTEVTLEEEPETVVTLNPSAAQTMWEIGAEEKVIGTTKHAENLEGAEERTNVSTDAETIEPEIVVDADPDLVLAPSSNFVSEETVETLREAGVTVFYFQSAESIDEVRDRTQLVGSLVGECEGAQETVDWMDEELEIVESALEGEERPDVLYTFFGFTAGEETFIHDLIEAGGGTNVAAEAGVSDYQQLSEETVIDADPEWIVLNTNSPEVPEGAAYESTTAVENDQVLTVEINHLNRPGPRVIHAVTTFAETFHPEAYAAAAAEHDGVEGGADDDDDHAETDVEGDGSTTDDVDEGATADGADESATDDESVAGGADDQPGFGIVAAVVALAVAAVSIGSSRYRHGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVX5</accession>
    <name>A0A3N6NVX5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88062">
        <property type="protein sequence ID" value="RQG88062"/>
        <property type="gene ID" value="EA462_14530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="379" mass="41835" checksum="F2D2AE76BEA85EF9" modified="2019-02-13" version="1">MLAGGATVVGTSVAGCLGGDGNGDGNGGDDSGEQTQPDSEEPEKPDQITVRAWGGVWEESLAANVGEVFTDETDIDVVYDNTDGPVMRGDIRTAVQQDREPPITVVWDLNTTIHTSYRQGLAADLNPDIVPNIDQAQDMARPDIDGDLPYINLYPYTYALCYNEDVVEDLTGDSEPVSSWDELWDPMYEDMLGAYNDPPGGGLISVLAELSDTELGPADEMEPAWDLARDLEPNLGYLGTDQSLGQTLREGQVAYAMAYLPNNIVAAQDDGEPVDWIIPEEGATVRMDGMYTPRNQDESQLYWGQEFINTALREDVQQSWMEHLQVPMLNQNIEPLEWMQGDTAFPTTQEDFDQLLETDLDLFAEHSSGWFEEFSQITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYY4</accession>
    <name>A0A3N6NYY4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86686">
        <property type="protein sequence ID" value="RQG86686"/>
        <property type="gene ID" value="EA462_16220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="103"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="335" mass="37415" checksum="EBBCF28594E3F32F" modified="2019-02-13" version="1">MNWWLKRTGQALFTIWAVITISFALIRGLPGDPGSRIREQAQRHNPSMSQSALERMIEARIPASYDDPIHVAYWEYLTSVAQGDLGYSTFRQAEVAPEIAAVLPWTILIMSLSMALMFSLGLALGALMAYKEGSRFDTALTGVSIFFNSIPYYVAAVLLIAVLGYRLSVFPARGTHSDATDPGLSLHFVFDVLYHATLPTLSFVVTGFGIIALTMRGNSIQTLGEEYIRVARLRGIPDRRIALRYVGRNAILPMWTTLLISIGFMFGGAIILEEIFQYRGMGWLMFRSIEHNDIYLMMGTFLIVTIAVVISLWIADATYGWLDPRIKSGDDSESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ51</accession>
    <name>A0A3N6NZ51_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90179">
        <property type="protein sequence ID" value="RQG90179"/>
        <property type="gene ID" value="EA462_09325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="368" mass="40005" checksum="0983D4FA465ACC6A" modified="2019-02-13" version="1">MVVQTAVVGAGTVSRTHLSGIQKNPRAELIGLCDTNGSAANARAREYGTVAVTDLDRLFEMEPDALHVCTPVQTHFDIASQAIENGIATILEKPATVTVDELEELDELADSNDVPLTVVHNHLFYPSVRRARELIDAGELGDLRGVDTIYAGITRPDSVKRGSWVFDLPGGEFEEALPHPIYSTLGIGGFPERADDISAQTACSREYDGGFSYDQAQIQFTSADGTLCTTKMLSETKPQRMHVINGSEGSLIVDEINQSVYRIEDDYTTSPIARSKKGLDLSLSQLSSTVENATMMASSRIDGGWEREAKLNSHYAIFDQFSRAVETGSEVPVPVEQSKWTIQAMEAIRNAAEGDDIPEQEQSVAVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZA0</accession>
    <name>A0A3N6NZA0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90249">
        <property type="protein sequence ID" value="RQG90249"/>
        <property type="gene ID" value="EA462_09720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="159" mass="17349" checksum="28E7D943297B80FD" modified="2019-02-13" version="1">MAGHVHAVHVAPVRGEPVERIERATAVAGRGLEGDRYFAAEGSFSDREGSDLTLIEVETLEAVEDEYGIALESGVHRRNVTTTGVKLDQLVGSRFRLGGVRCEGVERCEPCSYLERHLERAGVREALVHRGGLRARILENGTITPGDRIEIESGVHVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZC8</accession>
    <name>A0A3N6NZC8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90289">
        <property type="protein sequence ID" value="RQG90289"/>
        <property type="gene ID" value="EA462_09940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="262" mass="28799" checksum="8424EE5A58B9A81D" modified="2019-02-13" version="1">MIGSRPTRARWSDRRGITEVLSFVLVFAIVFLSVLLVGVGGFGAISEYQEHERLASAQLAIETFAENGNDLARSDGVTDRTGALGLQTGTVSPGERGTTLNVTVFDDDGDAWNWSEDYPDEDLGAFAYRTGSEAIVYEGGGVFRTGGDGSSAVVSDPMITCRENVAVITLVKLTHDDRTIQSDQRLTFALEQDRANTTRAYYDEAENVTIEIEGGPSSGGWEMFFENEERWTFDEDDERWACASDRVSIDVVEIGIDYSELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P080</accession>
    <name>A0A3N6P080_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87808">
        <property type="protein sequence ID" value="RQG87808"/>
        <property type="gene ID" value="EA462_13120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="329" mass="36844" checksum="FAA09ED17910567B" modified="2019-02-13" version="1">MVNLSYLGKRLGLMAVSLYAVITVLFFLFRILPGDPTSQVISPRFSAEQQEQLMAQYGLDEPLYTQYFLYMRNFMVGDLGQSFQHGEPVLPFILDRTINTLILTVPAIMIAFIVGPFIGALFAWHRNGRLDNYGTAIALTTYAAPIFWTGMLALMVFSFSLNILPSGGMRPAGEIPGSPLNRVFSFVTLQHAILPIVIFTLWRISRPILITRNTMIDVLGNDFIQLKKAEGTPESTIRYRHAMRNSLLPVVHYGALAIGYAFGGSVILETVFSWPGLGRTMWDAVQAHDYPVVQGAFFLMSFMVILFNFIADIVSTWLDPRVKDEGVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1J6</accession>
    <name>A0A3N6P1J6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="2">6.3.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88955">
        <property type="protein sequence ID" value="RQG88955"/>
        <property type="gene ID" value="EA462_11225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="Alpha_ANH_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022427">
        <property type="entry name" value="MJ0570_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="PTHR12196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039123">
        <property type="entry name" value="Diphthamide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03679">
        <property type="entry name" value="arCOG00187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="243" mass="26619" checksum="CBF327490506BEF3" modified="2019-02-13" version="1">MSDADGDGAWVSLFSGGKDSSWALYRALETGFDVRRLVTVHPTDESYMYHVPATDLATLAAESIGIDLLDVHPGDLEAGSATDSSVQGDDELEPLEAALTDLDRELEGGLAGVTAGAVESEYQTNRIEGMCNRLDCELFAPLWQRDPRTLAESMLEAGFEIVIVQVAARGLDESWLGRTFDRDALTELESLHEDYGVHVLGEGGEFETLVVDAPHMSRRIDLEYEPEWDGTRGSIRVTDAQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P210</accession>
    <name>A0A3N6P210_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91599">
        <property type="protein sequence ID" value="RQG91599"/>
        <property type="gene ID" value="EA462_06510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="65"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="197" mass="21514" checksum="1CF6CA6738C15C53" modified="2019-02-13" version="1">MPVIECDVDAARDRLENAGVEIDAGNTDHERWRATRGDATAVAYDDKIVIQGGNPRDLEAVLRDGGGRAHVYFDGAARGNPGPAAIGWVIVTGDGIVGEGNDRIGRATNNQAEYEALIAALEAARDYGYDEIHVRGDSELVVKQVRGEYDTNNPELRERRVSVHELLSAFDEWTLEYVPREVNGRADGLANEALDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P226</accession>
    <name>A0A3N6P226_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89185">
        <property type="protein sequence ID" value="RQG89185"/>
        <property type="gene ID" value="EA462_12525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="222"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="437" mass="46950" checksum="9BAC973817FA352F" modified="2019-02-13" version="1">MTEPIRDRLVTVRRHLHRHPEPAWREFYTTARLVEEIRAIGVNELAVGPDAYDPADRMAVPSDDEIDFWLERARDRGADDALLERMSGGNTGAVAVLERGDGPAIGLRVDIDGLFVEEATGDGHVPDAEGFRSEIEGTMHACGHDVHMTWGLAVLEAIAESDFAGRLVVFFQPAEEVGGGGCPMARSRFVDDLDYLLAVHVGLDHPSGEVVAGIEKPLAMCHVDVTIEGTSAHAGKSPNEGDNAMHAMGTAIENAYGIPRHADGMTRVNVGRAEAGTASNVIAERAHLEAEARGETTELMEYVKGRLERVVRSAARMHGCDAVFDVISESPRADSDPELVDVVVDVATGLHGTDRVVPTADFGASEDATFLMNRVQESGGLASYLIVGTDHPTSHHTPTFDVDEDALDHGVSVLVETIGELERRHPVSNAENAAEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P259</accession>
    <name>A0A3N6P259_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89215">
        <property type="protein sequence ID" value="RQG89215"/>
        <property type="gene ID" value="EA462_12680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="220" mass="23626" checksum="A646C6F0BAD82138" modified="2019-02-13" version="1">MTDNRSIPTDRESPVGAPVIRGDESVTGTRAREAVQFDPDDPESLEEAAETVRQFAGGAVDDDHLYMLRGAAACAALVRGEGSYKAAAERAGSDATVSFIRKWARVHDLPRSVRKQVALGAIAPTAAKHIARVAGEARLLLAWAAIDGGLTVREVRSVASSINDDVPIHRALAEFDVTLGQLEVTLSPPAYRDLRRQASIEGIEPGEIITDALEEYIETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3U3</accession>
    <name>A0A3N6P3U3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_076581923.1">
        <property type="nucleotide sequence ID" value="NZ_REFY01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90015">
        <property type="protein sequence ID" value="RQG90015"/>
        <property type="gene ID" value="EA462_08390"/>
    </dbReference>
    <dbReference type="GeneID" id="30955432"/>
    <dbReference type="GeneID" id="56033079"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="68" mass="7452" checksum="C6F4C0FCFB1B9B3C" modified="2019-02-13" version="1">MANGKVDFFNDTGGYGFISTDDGDLDDDEDVFFHMEDVGGEDLTEGTEVEFDIESSPKGPRATNVVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6E0</accession>
    <name>A0A3N6P6E0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
            <shortName evidence="6">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serS</name>
        <name evidence="9" type="ORF">EA462_04910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91325">
        <property type="protein sequence ID" value="RQG91325"/>
        <property type="gene ID" value="EA462_04910"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="139"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="6">
        <location>
            <begin position="241"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="272"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="459" mass="52300" checksum="013F9342A358B951" modified="2019-02-13" version="1">MLDRTHLRENPDEVRDALENRGADVDLDEIIEIDERWRELKARGDELRHERNEITQQIGQLVAEGKDEQREEAIDRSTELKGEIEGVETEADELRSELDDRMLEIPQVPHESVPLGLDERHNVEDRRWGFDDLRDLPTDVTPHYELGAEMDIIDEERAAKTTGSGFYFLKGDGARLEHALIQFMMDVHREQGYVDLFPPVPVKSASMRGTGQLPKFADDAYRLGGDNDEAYDDEDLWLCPTAEVPVTNMYANEILLGDDLPLKHQAYTPNFRREAGEHGTETRGIVRVHQFNKVELVNFVEPEESYDRLEGLLDEAEDILQRLGLPYRILELCTGDLTFASAKTYDIEVWAPGDDFEDGPEEGGRWLEVSSASNFEAFQARRAGLRYRPERHESAEYLHTLNASGLALPRVMVAILEYYQNEDGTVTIPEALRPYMGDREVLESLEKVGESALGAGERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6F1</accession>
    <name>A0A3N6P6F1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps3</name>
        <name evidence="11" type="ORF">EA462_05055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds the lower part of the 30S subunit head.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91345">
        <property type="protein sequence ID" value="RQG91345"/>
        <property type="gene ID" value="EA462_05055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_A">
        <property type="entry name" value="Ribosomal_S3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027488">
        <property type="entry name" value="Ribosomal_S3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_S3_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG91345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="316" mass="34489" checksum="3699B2FF4851020C" modified="2019-02-13" version="1">MADEHQFIENGLQRSQINEFFSEELGRAGYGGMDVAKTPMGTQIVLKAEKPGMVIGKGGENIRKVTTALEEKFNLEDPQIDVQEVEEPDLNARIVADRLANALERGWYFRKAGHTTIDRIMEAGALGAEIVLSGKVTGARSRVEKFNRGYIKHNGEPAEEIVDEGQGVAVMKLGTIGVTVKIIPPNAELPDDFRILEDLDPEEVVPDAVEANEAEGVEELLEGEPEEAEATESGAEAPAEDAVEPEPAVDEEDIEEVIEEEVSDDDEEEVETPAESPIEEDLDELEEDVEAEAEELMAEMDDDEADSDEPDEGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6L1</accession>
    <name>A0A3N6P6L1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91475">
        <property type="protein sequence ID" value="RQG91475"/>
        <property type="gene ID" value="EA462_05800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="147" mass="16521" checksum="E9A7AA12DFB2EA78" modified="2019-02-13" version="1">MDGLRWVQLTDRERTAFLGTGGTGVLSFGTESTDPPASLPVSYGYFDDDQAFYFRLSFPEGTTKDDVIENPVSFVTHGETDDGWRSVIATGTLEELGEFPHESVEVQGMWAVDIPKVDVFDRPRDEIPFHDFRLDPERLTGRKSVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIQ2</accession>
    <name>A0A3N6LIQ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenosylcobinamide amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87129">
        <property type="protein sequence ID" value="RQG87129"/>
        <property type="gene ID" value="EA462_15210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002808">
        <property type="entry name" value="AdoCbi_amidolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01955">
        <property type="entry name" value="CbiZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="277" mass="28870" checksum="E21875100E6ECDA8" modified="2019-02-13" version="1">MTEADPPYEATRRDGVLCVRDQETEWLSSGWNGGRTTADCAYNVSVPEGWNRTDLEAYITDRLERARFAGESDPVGNQPAPVRAPVLLTGVDIEHARGARCGSVTAYATAGISNPAALPMEPTSEAGLEDVVSQPGETRTEGPESPGTVNLIVGTTRALAPGALTNALAVAAEAKATTLLAETGFPGTTTDAIVVGHDPRGRRAAFSGSATPVGAATRACIREALRASLRSRYGDSDASVPNTVTDAADGVSTDVEARVFRPPRESSTRDRTADTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJL7</accession>
    <name>A0A3N6LJL7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88913">
        <property type="protein sequence ID" value="RQG88913"/>
        <property type="gene ID" value="EA462_10995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043927">
        <property type="entry name" value="DUF5778"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19090">
        <property type="entry name" value="DUF5778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="138" mass="15222" checksum="C0508CE781BC1702" modified="2019-02-13" version="1">MTDANSSPVDDDLYRRTKALLEPGEIDLNGVIIQTPYDGSEDVRMMQATIDAGDIIAEHSGYDPQDCFVHSGNDDPEFSSNQHQGLTLGDEAFVWECQQLLREGSFDVVMYYDGRADHEAILEGITDLGYDVTGVEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKD1</accession>
    <name>A0A3N6LKD1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89078">
        <property type="protein sequence ID" value="RQG89078"/>
        <property type="gene ID" value="EA462_11920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="267" mass="29007" checksum="04D28181D1709EFF" modified="2019-02-13" version="1">MTQDRNDEIEIEIERGSADESDRRFDVTDRPGNATNTSVSGDSRNRPDGFDPTQHLEDELGRIDIRTTAEGYVEGRVTGLESVDETTVRLEVELPHGERIRFSLEKPIPWSEEFLLARIVEDVGYDAPSISHLVGEPIYLTRVDDSVAAGDDENDGRWWAPSTRSLGDVVLSSLGSRFRLVERTSSQWRLVDPLERRSTEDDRSGTTVDATTVASWLLVLTAPVIAGFGVGASTPGELAGSSAAVGYVLGGFVLALIGLAMLTAGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKF5</accession>
    <name>A0A3N6LKF5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF368 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89273">
        <property type="protein sequence ID" value="RQG89273"/>
        <property type="gene ID" value="EA462_11115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="320" mass="32806" checksum="7C077D6BA3CA7C8B" modified="2019-02-13" version="1">MGYNLANRTVDWFDVLRTYGYGLCMGTADALPGVSGGTVALLLGFYGRLIAAITALTPGRALAVLRGYDADRRDRARTALVEMDLEFLLPLGVGMVTAVALIATTVSALAESHPIALFGFFTGLIAASAIVLFRSLEFSSPAHGLAGSAGVGLALLVASNVIQLPGSGSVLIFLAGALAISAMILPGISGALILILLGQYVFLSAELSAFLDSISALVSGSGSVAAVLEPGATVVVFVLGGFVGLVTIARVVRRALEARRELTLLFLVGLIAGSIPAPLYSIDEAYAWTTDIVVLTGAWALVGIVALLALDILAGGFDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM28</accession>
    <name>A0A3N6LM28_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88797">
        <property type="protein sequence ID" value="RQG88797"/>
        <property type="gene ID" value="EA462_10350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="245" mass="26478" checksum="5AAA1423801B4348" modified="2019-02-13" version="1">MRDVCIVGGGVAGLAVSIFTARAGLDTLVVDGGESILARNASLENYPGFPNGVDARRYLQLTREQASEAGATFELGHVTSVEAKDATNFEAGFVLETEAGEPLEARRVVAASWSDSEYLVPLDVGRTQRGSKHFVSVDEGGRTAVDGVYAAGRVAGEPHQTIVAAGHGAKVALAVIHDSDANFYHDWVVPEGYFTGRGREVPPACEEIDDTERRRRDERARTRLLEAFDEPLEEVPTMHPSVERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM31</accession>
    <name>A0A3N6LM31_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proS</name>
        <name evidence="9" type="ORF">EA462_10405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88807">
        <property type="protein sequence ID" value="RQG88807"/>
        <property type="gene ID" value="EA462_10405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="47"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG88807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="493" mass="55255" checksum="9F65917EB77A99ED" modified="2019-02-13" version="1">MSDESQELGITESKSHKPGEWYAEVVQKAGLADYAPMGGFIVTKPRGYALWERIQDALDDWFKATGVDNVYFPMFIPESYLEREKDIVEGFDPEVAWVTQGGHDELEERLAVRPTSESIIAPFMAEWTRSHRDLPLRLNQWCSVVRWEATETKPFFRTKEFMWQEGHTAHATDEGAWEEVWTRLDQYERVYEEVLAVPVLRGKKPDHDKFPGADTTTTVEALMPDGKSVQGATSHNLGQSFAEAFDITFADEDEAEQTAHTTSWGLSWRALGALIMTHSDDQGLVLPPTIAPTQVVVVPIWQEETRDDVLEYANALTAELEEAGVRVDLDDRDERNPGFKFNEHELNGVPLRLEIGPHEVEDEQVTLVHRPDNENAVADREDIAAAVDDHLETVFEKLYDAAEENLTENVREAYTPEEILGTIGKHGGYVKTSWCGDPACEEAIKEKIAAEIVMQPLDDEGGSSAGAVPEPDHDDCGVCGEPADEIAYFAKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM71</accession>
    <name>A0A3N6LM71_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_10735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88867">
        <property type="protein sequence ID" value="RQG88867"/>
        <property type="gene ID" value="EA462_10735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="26"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="238" mass="25042" checksum="664316F01E82708B" modified="2019-02-13" version="1">MPLDLPILSLLFVDFPFEWNYIRSIIRVSLYVSITAVVLSTLFSIPVALLVGFKDFRGKTLLTSIINTGMGFPSVVVGLIVLFTVSNEGPLGSWDLVFTPEAMIMSQFVLAAPVITGVSLAAVSSVEQNVRDAAYAMGGTKMDVALVTIKEARYGIATAVLAGFGRAISEVGSVLIVGGNIAGSDGTSVTRTLTTAIQLEARQGRFETAMILGAILVVLVLLVNAIVVRLGNGGGRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM76</accession>
    <name>A0A3N6LM76_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86191">
        <property type="protein sequence ID" value="RQG86191"/>
        <property type="gene ID" value="EA462_17125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="66" mass="6666" checksum="23F7A74E03945015" modified="2019-02-13" version="1">MSSSPVGQFLGTFLVVGGVAIVVASMVSPPDPFTVARYVFVAVVVAAIVSAVLASTNVVTALTDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMC8</accession>
    <name>A0A3N6LMC8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90233">
        <property type="protein sequence ID" value="RQG90233"/>
        <property type="gene ID" value="EA462_09625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="46"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="212" mass="22733" checksum="C7F2AE4A9846A521" modified="2019-02-13" version="1">MKRTIEEHAARFDEQASDYDDEKSAEYRACANLVIEHATPGDDDVVLDLGTGTGAIALALAPDADLVVGRDISEGMMEKAETKAADRGFENVEFGYGTFREPEVDLESSETSGVDIVTSNFAMHHLSDDEKREAISVIAALGAEKLVLGDIMFFDEPDSDTSFYSPVVDDPATVGILADAVTDAGFSLTAVERVHDLVGVLVAERSRPSGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMG4</accession>
    <name>A0A3N6LMG4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="3">DHBP synthase</shortName>
            <ecNumber evidence="3">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ribB</name>
        <name evidence="4" type="ORF">EA462_16445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86725">
        <property type="protein sequence ID" value="RQG86725"/>
        <property type="gene ID" value="EA462_16445"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="219" mass="23539" checksum="C6976133FBD13375" modified="2019-02-13" version="1">MTASDDFEIETDQLADAVTAFANGNPILAYDSADRENEVDIIYPAATVEPQDVTRLRNDAGGLICVALSDTVATALELPFARDTLDHPVAASEELKYDDRSAASITVNHRDTFTGITDQDRSVTINRLGALAADPTTEAFVEEFRSPGHVQLLRAAPNLLADRRGHTEFAIALTAKANRAPVAVVCEMLDDETGGALSPAAAKRYAASEELVYVDMSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMK7</accession>
    <name>A0A3N6LMK7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90363">
        <property type="protein sequence ID" value="RQG90363"/>
        <property type="gene ID" value="EA462_08485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045396">
        <property type="entry name" value="DUF6517"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20127">
        <property type="entry name" value="DUF6517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="216" mass="23391" checksum="C18671D245129F6E" modified="2019-02-13" version="1">MPFARRSILAAGATGTLAVTAGCLDFVLGDGPLEFEAGRVAPSESALSETGYNEAEVDEETIEETVEVGGLEREVRATLWLSTYTKTRTIEGIEHDANSFVAVSVPGMEVMGRSFNPLEDMSNEELLEEFVGQANVDVDDIQHKDSFSLETLGEGRDVDRFTGETREGGETIAVELALTSFRHNDDSIVLLGTHPELLAEESANVELLMESAEHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMN4</accession>
    <name>A0A3N6LMN4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90318">
        <property type="protein sequence ID" value="RQG90318"/>
        <property type="gene ID" value="EA462_10100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="194" mass="22545" checksum="4F2AEE5ED9007DE7" modified="2019-02-13" version="1">MNASALQRRFSLTMSTTGTQSTDNHVSPQRAFDRLVWHNPRYCNGCFERIKEIEEADPRVTLPDPGVREPIVPLGGCRGWPAARLIVAGAHGRDDRPRSPRVRQGRESRRERIDWMADLEGSVARDFIVRRARRNWKCRSYSSVESTLIRPMIYICERSISSYARNPPRRRLRPRNGRRLFDQTTRRSGSRRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMV0</accession>
    <name>A0A3N6LMV0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">EA462_12640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89207">
        <property type="protein sequence ID" value="RQG89207"/>
        <property type="gene ID" value="EA462_12640"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="272"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="422"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="512" mass="56827" checksum="AA0D9A5C977EF6F1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNA9</accession>
    <name>A0A3N6LNA9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3194 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0440 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87075">
        <property type="protein sequence ID" value="RQG87075"/>
        <property type="gene ID" value="EA462_15700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024502">
        <property type="entry name" value="DUF3194"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035954">
        <property type="entry name" value="MTH677-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11419">
        <property type="entry name" value="DUF3194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="86" mass="9279" checksum="472B774867B5E4A4" modified="2019-02-13" version="1">MTQAEPTDEAVVQTASDAAEGLIFSRYKQSVVRDCDVTVTFEEGVLDVDVYVNVPDDEGSHDPERVADDAALAAQEAVDELFEESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPC9</accession>
    <name>A0A3N6LPC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91298">
        <property type="protein sequence ID" value="RQG91298"/>
        <property type="gene ID" value="EA462_04740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="183" mass="19205" checksum="A0A4D63A82EBBC1D" modified="2019-02-13" version="1">MTDPNSDDHPTEPERDVGTETGEETADSAGTVDSGTGYGDRSSDGRDPRAESTRVANEERRRNTAIVSAVVAAIGAWVALSVLVFDAGESSLWNNVLVGGVVFVAAGYNTYRIRSDVPTSIGITTLVAVLGIWLIVSSALFGMLESLFWSTLVSGLLIAGLSGYNTYEAREAQAIASGTKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPN2</accession>
    <name>A0A3N6LPN2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_05605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91443">
        <property type="protein sequence ID" value="RQG91443"/>
        <property type="gene ID" value="EA462_05605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="159" mass="17604" checksum="F0F9EDBFE5A99F87" modified="2019-02-13" version="1">MLDVGDEAPQFELPNQHGDLVQRSDFGGQRLVIYFYPRANTEGCTTEAREFNDAIAEFTEHNAAIVGISDDPVDDIEPFAAEYDLEFDLLSDEHGEVATLYDSYGEKQMFGNTFDGVFRNTYVIAPDGRVETTYEDVSPGGHAAAVLETLESESHEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPW9</accession>
    <name>A0A3N6LPW9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="4">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nirK</name>
        <name evidence="8" type="ORF">EA462_06445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91588">
        <property type="protein sequence ID" value="RQG91588"/>
        <property type="gene ID" value="EA462_06445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02376">
        <property type="entry name" value="Cu_nitrite_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="86"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="363" mass="39503" checksum="94D91C7D3A5A785D" modified="2019-02-13" version="1">MTISTATRRTFMQAAGATGAVAVAGCLTGERVENDPEPEASDADEGLRPAEAVDVDRIGADPADVPPPVDWNEPRTHEFTLETVEVTAEIEPGVTVEYMTYEGQIPGPMIRVREGDTIDLTFEVPDDLNRTVHNVDFHAVYGPGGGAEATTIRPGDEPARLQFETRYPGVHIYHCAVPAMDQHISLGMFGAILVEPKDGLPEVDREFYFGQHELYTDGEMGEEGHHHFDFDASADEEPTYVLLNGEAYGFTEDGQHGPVEAEVGETVRVYFANGGPNFTSAWHPIGNVWSRLYRDGDLLTEPARYVETSPIAPGTVVAGEMELPVPGPIKIVDHALSRVVHRGALATIDVEGEPNPDVYDEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPY0</accession>
    <name>A0A3N6LPY0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate 5-kinase</fullName>
            <ecNumber evidence="7">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-glutamyl kinase</fullName>
            <shortName evidence="7">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proB</name>
        <name evidence="9" type="ORF">EA462_09825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90267">
        <property type="protein sequence ID" value="RQG90267"/>
        <property type="gene ID" value="EA462_09825"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG90267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="277" mass="29534" checksum="9844034E34DC2860" modified="2019-02-13" version="1">MSNTAEPGAVEAARRLAMDAERVVVKAGTNSLTDEESNLDNEKLDKLVDDVVSLLDQDRDVLFVSSGAVGAGTGRVGYTDDTVEASQALSTVGQSHLMHRYTESFGRYDRKVAQILLTQNDLDNPDRFTNFKNTVETLLEWGIVPIINENDAVATEEIRIGDNDMLSSSVAIGVDSDLLVTLTDVGGVYTSNPKEDPDAERIEAVGRNYADVQTLVDRSSSASFGGIQTKVSGARTVSEHGIPAVIAKSTEADVLEKIVAGKAVGTLFVPPNGSTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPZ6</accession>
    <name>A0A3N6LPZ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90287">
        <property type="protein sequence ID" value="RQG90287"/>
        <property type="gene ID" value="EA462_09930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="301" mass="32369" checksum="BAC0668754946C92" modified="2019-02-13" version="1">MVAPTRDRGQVILIGAIVIAFVILGTVVAFNGLVQTEEASSSATSQSVTHATVAESELQQGLQNLAAHDVQRAGGWEAIIDDERVSTALRDDSEWEDAGRSLGELHGNLTRSERVAVTDIRVHHAGGDERLEAIYGERNPPGHEDILERSATDGSRVLSLNLTGWTPNMDGELVIRETNGQTTHVEIESGSDPTPVTINSTSDRFAGERSCEADAVDLVTGTIENAAGSCDEMAIVDSSREYEYIESREGNGQFTYDLVAIGDVVGEDDGVSASVTVTYTYHSNDLRAERTTTVDLYGDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQL5</accession>
    <name>A0A3N6LQL5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV pilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89284">
        <property type="protein sequence ID" value="RQG89284"/>
        <property type="gene ID" value="EA462_11780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012859">
        <property type="entry name" value="Pilin_N_archaeal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07790">
        <property type="entry name" value="Pilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pilin_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="149" mass="15187" checksum="F88FBB7A15CA9EFD" modified="2019-02-13" version="1">MSPVVGVVALVAITVCLAAIVAVGAASLSLGSTAPTAAFDLSVDGDENEIVIEHVAGESLDVRELSIVVAVDDTRLSEQPPVPFVGANGFEGTPSGPFNERSDPTWHSGEHASLTVARNNDPSPNSGDSVSVSLSVDGHRLATLETVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRM3</accession>
    <name>A0A3N6LRM3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">bPH_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89794">
        <property type="protein sequence ID" value="RQG89794"/>
        <property type="gene ID" value="EA462_07180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="61"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="153" mass="16810" checksum="3A9D48160D9619E7" modified="2019-02-13" version="1">MESLHPRIRILWIAQWAITAGILGLMAAGVDRFIVDVPLSVQGGIVAVGIVLATVYALRLYQVWQFELQPDALYLERGVVTFVETAVPFVRVQHVDTQFGPIERVLGLSSVVVYTAGSRNADVRVPGLTPDRARELQDTLRELAVESEADDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRN2</accession>
    <name>A0A3N6LRN2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_07280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89814">
        <property type="protein sequence ID" value="RQG89814"/>
        <property type="gene ID" value="EA462_07280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MacB_PCD" evidence="6">
        <location>
            <begin position="37"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="419" mass="42214" checksum="D40D4DB8866B4DB5" modified="2019-02-13" version="1">MRDDTEGTRRSRWRGLVGFSLARLWTLTTRTRSGRILATISAVALTIALLVIVSGVALALADGSVASQNDADVRIVPEKSGVLSTVDGVEGPRLGDATDRATTIRSASGVDHASPVLAETGSLETADGGEARSVLFVGAVADEEPRTVAGLSTDGLEPGDPHYANGSFDGPPSGEVVLSAAAADRLAAAEGDELAVPMPHEDGSSQLSLTVTAVADERDDDASAPIALVHLSELQSFAGSSDDELADEVLIWGETGAAQSGSADAYPDAAVETSGTADPSSLFDDGLAFATSVLALVVGIAICTSFVATTAGMTVNEDRRTLAVLESIGVPTLGRLSVVALSTIATTLCGALLGAGLGIVGIHAVNAAATATVASGAIALSHPILVPYAVVISLVSGLLAIPYPLTVAARTSVLEEVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRQ1</accession>
    <name>A0A3N6LRQ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase family protein subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91107">
        <property type="protein sequence ID" value="RQG91107"/>
        <property type="gene ID" value="EA462_03665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="295" mass="31766" checksum="ED9B7034E8EEC030" modified="2019-02-13" version="1">MKAAPFEHHEPSTTDEAVSLLESLERPTILAGGQSLVPMLRFRLARPETVIDINGIDALDYLREEAGFLRIGALARHADVADADVIAESYGSFADTAPLVADPQIRNRGTVVGSITQADPKGDWGSVLLAHEGAVVAQGPDGERVIPADEFFLLPYDTTLEESELVTEVRVPTPDAREGSAYHKLKRKTGDYAMAGVATRLVFDEDGRIETAGIGMTAVDITNARARDAEDRLEGERPSSALFEEAGELAAEESNPESDEHGDASYKERMIDVLTQRALGDAAERAGVVKRTVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRY7</accession>
    <name>A0A3N6LRY7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91237">
        <property type="protein sequence ID" value="RQG91237"/>
        <property type="gene ID" value="EA462_04400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="91" mass="10823" checksum="51DE5D7C43598BE6" modified="2019-02-13" version="1">MHDLTGFQRDLLYVIAGADRPSGQTVKDEVEKYYSSEINHGRLYPNLDTLVNKELVEKGQLDRRTNYYAITDDGRQRIDERREWERQYVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS19</accession>
    <name>A0A3N6LS19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA carboxylase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90024">
        <property type="protein sequence ID" value="RQG90024"/>
        <property type="gene ID" value="EA462_08440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="71"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="340"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="594" mass="65458" checksum="67DA0281770092DB" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS81</accession>
    <name>A0A3N6LS81_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLDc_N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91377">
        <property type="protein sequence ID" value="RQG91377"/>
        <property type="gene ID" value="EA462_05220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="102" mass="11570" checksum="8E698CF94FABD5CB" modified="2019-02-13" version="1">MDTVLLAIIVGIPLAWHLVLTVVTYYDAGRVGLEPPRKWAVITFAVPIFGFFIYLFERSELSYDPETDPYRGNTINVHPSRADEVPLSSRSDERPSSTRDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSK4</accession>
    <name>A0A3N6LSK4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF393 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92928">
        <property type="protein sequence ID" value="RQG92928"/>
        <property type="gene ID" value="EA462_01520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="128" mass="14517" checksum="CD0328B69C6A4BDB" modified="2019-02-13" version="1">MADATLVFDDDCGFCTWWAEYFDDRSEIRIVGFSDLTPGLRERLPDEYDSCSHFLADGEVHSCGASIEAALVHSGLAGPVTDVVEFLRNFEDYERLRERGYEWSANNRDLLGRFLSKTPPARRTGDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSQ1</accession>
    <name>A0A3N6LSQ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91567">
        <property type="protein sequence ID" value="RQG91567"/>
        <property type="gene ID" value="EA462_06325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="115" mass="13117" checksum="233662B6AAC4F091" modified="2019-02-13" version="1">MVDLTMNVNTQTVTTEVALELVTDQCRQQILHHLIENEDGAVDIDELVDRINSANVRTERPHRSPSHLKMTLYHAHLPKLAEAGVIDYDAQSDTVRYHATTRVEKLIAFITDELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSR6</accession>
    <name>A0A3N6LSR6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR system precrRNA processing endoribonuclease RAMP protein Cas6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93013">
        <property type="protein sequence ID" value="RQG93013"/>
        <property type="gene ID" value="EA462_02030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019267">
        <property type="entry name" value="CRISPR-assoc_Cas6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045747">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10040">
        <property type="entry name" value="CRISPR_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRISPR_Cas6" evidence="1">
        <location>
            <begin position="154"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="288" mass="31200" checksum="D6F94EC0B8C404B1" modified="2019-02-13" version="1">MAQQSHSSARTRRVEIRLRPEERFAVPLSDGYSVYSALLSALESADADASARVHDSQIGSLHTSGLQGVFGDSDRSHHKLALPNEEYRLSIGITDPEDEAIFQALVAALVLEGDSIELTNGSLRVDSFESENSSHQDLLETAASFDDPSLEFDFETATCIEEAGSVTTMFPVRTAVFSSLLGKWNRTAPENLEVDVSRDAIASSVIEKPDDSSYRTHSVLVNRVEDDDGNPRPIFRQGFSGRCTYAFKDASESVENALSALALFAEYSGVGSAVARGCGNVNIQVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT00</accession>
    <name>A0A3N6LT00_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91717">
        <property type="protein sequence ID" value="RQG91717"/>
        <property type="gene ID" value="EA462_05715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="478" mass="52389" checksum="A293C01C2BF37676" modified="2019-02-13" version="1">MTSETLVERYLERIDAYDRDGPVLNSIVTVNDHATDRASELDEAFDQSGTFVGPLHGIPVLVKDHIETTDVVTTFGSEAFDEYTPETESDVTRRLRDAGAIILAKTNMPDWATSWFGFSSVAGRTKNPYDPDRDPGGSSSGTGAAVAANLGAVGIGTDCGGSIRVPASFDNLVGFRVTPGLISRSGMSPLVSQQDTAGPMTRTVRDTARLLDVLVGYDEHDELTGRTELRWNAESYTNYLGADGMTGARIGVLRDGFGDEENPDAAPVNRVIEDALTAIRNCGATLVDPVELPRLNQYLEETMLYILQSKRDLDRFLADRKTPVEGVDELYERGQYHDLLDLFEGFAEDGPDDLTDHVEYWKRRNAQQRFQEAILNVFAKHDLDAIVYPDVQVLPPTENEIRDGKYDTMTFATNTIIASQSLCSAVSVPAGVTNDGLPVGLEILGKPFDEPTLLELASAFEHVTDHRRPPETTPPLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT03</accession>
    <name>A0A3N6LT03_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_02745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93138">
        <property type="protein sequence ID" value="RQG93138"/>
        <property type="gene ID" value="EA462_02745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035097">
        <property type="entry name" value="M29_N-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="369" mass="40685" checksum="04D7BB630B19038B" modified="2019-02-13" version="1">MDPRIREHAEIIATHSVDLEEGDNVVVDAHPVAEDLVVALHEVIGDRGANPVTTSQRTGKRQQRAYLRAAEGDDAEPEFETPDHELALIENTDVYIAIRATDNVTQTADVDPVTSAAYSQAQRPILEERLSKRWCLTQYPAPANAQLAEMSTEGYENFVWDAVNRDWDAQRAHQENMVEILDPADEIRIVSGETTDVTMSIAGNPTLNDHGEHNLPGGEVFTAPQPDSVEGEVLFDMPLYHQGREITDVSLEFDGGEVVSHSAAKNEDVLTEVLNTDDGARRLGELGIGMNRDIDRFTYNMLFDEKMGDTVHMAVGRAYDDTVGSGNEANDSAVHVDMIVDMSENSSIEVDGEVVQRDGTFRFEDGFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT81</accession>
    <name>A0A3N6LT81_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93238">
        <property type="protein sequence ID" value="RQG93238"/>
        <property type="gene ID" value="EA462_03320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="158" mass="17354" checksum="3D400F3936CED44D" modified="2019-02-13" version="1">MTAFVRVATRDDSLEVRRILDAAMLEPGNVEARIHNGEVLVAGDRRARSTGSARANAVHGDGRTRSDDSREAERLLGALVLEPHGNQPGAHVSAVGVRRRHRGRGIGSALVERALEDEGRLTARFDDRVRPFYERLGFSIESIDGERHRGIAVADKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LTF2</accession>
    <name>A0A3N6LTF2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_03095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93323">
        <property type="protein sequence ID" value="RQG93323"/>
        <property type="gene ID" value="EA462_03095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="3">
        <location>
            <begin position="165"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="670" mass="72239" checksum="101615FAB0CF7E7D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUS3</accession>
    <name>A0A3N6LUS3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="6">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_04975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91334">
        <property type="protein sequence ID" value="RQG91334"/>
        <property type="gene ID" value="EA462_04975"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006401">
        <property type="entry name" value="Rib_reduct_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01508">
        <property type="entry name" value="rib_reduct_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="10">
        <location>
            <begin position="2"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG91334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="221" mass="23655" checksum="07618131EE7375F5" modified="2019-02-13" version="1">MHVVVNAAMSADGKLSSRRRDQIVISGDADFERVDQLRADSDAVVVGVGTVLADDPHLTVKDETLCRRRLEEGQSEHPARVVVDSTARTPTDAAVLDDAATTYVCVTDAAPVDSRMGIENHAELVTAGDDRVDLLRAFAALEARGLERLMVEGGGELIFSLFEAGLVDELQVFVGPTVIGGRDAPTLADGEGFVDEFPTLALESVRRLDDGALLRWTIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV33</accession>
    <name>A0A3N6LV33_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_05955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91504">
        <property type="protein sequence ID" value="RQG91504"/>
        <property type="gene ID" value="EA462_05955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="310" mass="33141" checksum="2FA0867FC900FFB9" modified="2019-02-13" version="1">MAAIELRGVTKRYERRGILHTDSVTALQNVDLTVEDGDVFGFLGPNGAGKSTAIDIMLDYVAPTSGSVRVLGHDVDSDSVSVKERTGVLPDGYGPVSERTGREHLEFAIDAKDADDDPDELLARVDMLGPDGYPVDQYSKGMAQRLMLAMALVGEPDLLVLDEPSTGLDPNGARTMRRIVREENDRGATVFFSSHILEQVEAVCDRVAILDAGRLVTVDSIDRLRDTVGGSARVRLELSTVPDGVIERLEGIEGVSSVDVDATTVDVACENRAKAPAIATCYDSDATVTDVSTTEPSLDELFATVTEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVF7</accession>
    <name>A0A3N6LVF7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91674">
        <property type="protein sequence ID" value="RQG91674"/>
        <property type="gene ID" value="EA462_06940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="372" mass="38312" checksum="FC58D45BB2257C6A" modified="2019-02-13" version="1">MTETVRTDAGSGTSAVVSGVGTGFAAVTMAALVVPIRRGVEAPSVWAGAAFAIVCVLAFLASRRTGIDRRIVSAVAAVSSAVVVIVSAYALNQGITASVPLPIGSWSLSLVFVAFFTAGLTAGIGVAQFVGIDGGGLKDRSLHTTSLTVLGLGGLVAAQVATALVALPLMLVIGTLSLTQLVVVSQLGMALGTGAVAIGYLVYRGDGLSYLDLEMPTVRDALWIVAGVFVLFGALMAISAVFYTVGVESSEHGTAQQAQTNPEILLVLIPASLLIIGPFEELLYRNVIQKSLYETFSRYGAVVVGSVVFAIVHVLAYGTAGPGEVIASLGVIFGLSLVLGTIYERTENLVVPAVIHGIYNAILFTNLYAMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVH2</accession>
    <name>A0A3N6LVH2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91694">
        <property type="protein sequence ID" value="RQG91694"/>
        <property type="gene ID" value="EA462_04480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="127" mass="14636" checksum="859AF4E7B48C16B3" modified="2019-02-13" version="1">MVDDDLELERDLGEAEIVYEDPEEGTVTKRVPNEHVAYFQDHWIVKTDEDEEGHDIVRRIPARRVHYVERSVEQFEEEVQTLVDQVQSFASNLRTKIPVGGDTSEDEDAPPVEIGLDDDEGRQNSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXC1</accession>
    <name>A0A3N6LXC1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_16190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86681">
        <property type="protein sequence ID" value="RQG86681"/>
        <property type="gene ID" value="EA462_16190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="85"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="453" mass="49473" checksum="855A2D093E2E2228" modified="2019-02-13" version="1">MKQTRRTLLRNASKLSIVLGGLGVAGATVTAEEYPEWNPDETYTEGDRVVHEGSVWEAQWWTQGDEPGESDWGPWEEVETHDPGPSASFSVSDSSPDPGDDVEFDASESAGNLESYGWEFDDGETATGEAVTHSFDDDGEHEVELTVEDVDGESDSTGSTVYVGDVEPPDADGVYSPYQGTWYDIVDGTLERDTDRVIMSFIGDGTRDDEISPAWLADCQNHECGEESLDTYAGEIQTLQDEGIEVGLTIGGWESPVLARDADDPEELKDAYIDLLDTFDATHLDIDDENAEDPDRPDGLHEIRNEALALLKDERPEVTVGFTVSASPDGLADSGHSPGKVFIEDAVEKGLELDYVQAMAMHFEDEPENFETITSALESAVDFLEEVYPERSEDELWGMVGVTPYVGEITTNDASDLVDFAAEKGMYSIAPWVLGEDDGGEFSAVFSEFESGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY21</accession>
    <name>A0A3N6LY21_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PyrE-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_17110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86188">
        <property type="protein sequence ID" value="RQG86188"/>
        <property type="gene ID" value="EA462_17110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01214">
        <property type="entry name" value="PyrE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022854">
        <property type="entry name" value="PyrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF41">
        <property type="entry name" value="PTHR19278:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="79"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="216" mass="23202" checksum="06AC7A25365382D9" modified="2019-02-13" version="1">MKNVDDLIESAAELATRGLSKGEIADELNVSRETASWLVERSDTAPTGQSAADTNERSVGGPQDIHVDWSAIGRDSKRMEYIAAAMADMLAKHGEDVDLTVGIEKAGGPVATLVARELETDLSTYTPAKHQWEEGDMDDLGGTFSRNFAGIRNRECYVVDDTITSGTTMRETIDAIRAQGGDPLACIVLADKQGIEEVDGVPVYSLLQVISVGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY80</accession>
    <name>A0A3N6LY80_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86662">
        <property type="protein sequence ID" value="RQG86662"/>
        <property type="gene ID" value="EA462_16090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="9"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="306" mass="34341" checksum="DE5C8CFD63E3FB53" modified="2019-02-13" version="1">MARLYAWWSESGGPGKTTNCMNSSAAISRDGHDVVVLDLDPQRGSITHYAGYDNLTHGEVETTVMDVFFDDVDPREIIVPTTHFDLVPGHESLTNFESELNNDGRRGVSQFTVVRDVVEDLAEDYDYVIIDCPATLTDLTDNAIFAARNIMVPLELTPKGEASQDGLEDTVGAMHDGFADLGVEISIAGCIPSRVDQAKIFEEYRERFEEKDVPVSPFSIPEHSLLKYSWDEQMDLFAFMESDKTRDLRPYEEHVPMAFKVIGRMMTGEYSYDDAIDRWDTVKDTEMGDADPEAVLNDLDETRANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYS6</accession>
    <name>A0A3N6LYS6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87833">
        <property type="protein sequence ID" value="RQG87833"/>
        <property type="gene ID" value="EA462_13265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="119"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="325" mass="36001" checksum="37E0329F04416807" modified="2019-02-13" version="1">MKLATFEPPEEACLDQRVGCYDDDAETLVDVTAAYATLLANRGEQCPNEIARAHAPTDMIAFLERGERATDAAEEAIEFVRETGGGTGIDGRRLAYDLDEVSLLSPVPNPTSLRDYMVVEEHVRNALGDDIPEEWFELPVYYKADSNCIGHPDQDIEWPSYTEEMDYELELAAVIGKEGRDIAAENADEYIAGYTIYNDLSARDMQFREMEVNLGPSKGKDFNGSNVLGPFLVTPNSIRIDDVRMTARVNGEVWSEGTLGAMQHSFAEMIEHTSQSQYLYPGDVLGSGTIGMGCGLEMDRYLSRGDTVELEVEGIGTLRNRIVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYT6</accession>
    <name>A0A3N6LYT6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">leuD</name>
        <name evidence="12" type="ORF">EA462_02135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93034">
        <property type="protein sequence ID" value="RQG93034"/>
        <property type="gene ID" value="EA462_02135"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG93034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="213" mass="23168" checksum="F8F9DA8F932D97B8" modified="2019-02-13" version="1">MSGTDVDIPEVDSASGSGVPIRGNDIDTDQIIPARFMKVVTFDGLGEFAFFDLRFDENDDLKEHPMNEERFQDSSVMVVNSNFGCGSSREHAPQALMRWGIDALIGESFAEIFAGNCLALGIPTVTADSETIGELQEWVEANPDGELEIDVEAETVTYGGQTIDVTVDDAQRKALVEGVWDTTALMKSNAGEVRKTARDLPYVTDEQIPDAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYY6</accession>
    <name>A0A3N6LYY6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_14995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86962">
        <property type="protein sequence ID" value="RQG86962"/>
        <property type="gene ID" value="EA462_14995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="234" mass="25013" checksum="F339DDD5652653AB" modified="2019-02-13" version="1">MIEFDSVSYAFEDVPVIDELSLSIDDGEFVALAGANGSGKTTLLRHCNGLLSPDEGAVLVDGRPVEDDLIAARSSIGMVFQHPRDQFVAATIGADVAFGPENLGLERSEIDRRVEASLEAVNMAGRETERIDALSGGEQARVAIAGALAMEPSHLILDEPFTGLDDPARRSVLSRLESLAENDTGVVLATHDLRDVIDLADRVVAMRNGRVIVDDRPDRALAGLDGAEVRVPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ46</accession>
    <name>A0A3N6LZ46_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87032">
        <property type="protein sequence ID" value="RQG87032"/>
        <property type="gene ID" value="EA462_15435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="61" mass="6968" checksum="3302C387007B9300" modified="2019-02-13" version="1">MALNKLRQLDPDSAGITLPKGDLQVEGLLDQDGRVDGEYYFHIRHVDDGEWTLERVEEIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZE4</accession>
    <name>A0A3N6LZE4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="3">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcn</name>
        <name evidence="8" type="ORF">EA462_01620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93294">
        <property type="protein sequence ID" value="RQG93294"/>
        <property type="gene ID" value="EA462_01620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PTHR11352:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PCNA_C" evidence="7">
        <location>
            <begin position="122"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="247" mass="26914" checksum="EEF98611589619B6" modified="2019-02-13" version="1">MFKAIVSAETLTSALDSVSVLVDECKIHLEEGGLEIRAVDPANVGMVDLSLDAASFESYEADGGLIGVDLSRLEDIAGMAESGQLIQLELDEETRKLHIQIDGLEYTLALIDPDSIRQEPDIPDLDLSAEVVLEGKDVNRSVTAADMVSDHIALGVEEPEEYFYVDAEGDTDDVHLELTHDDLIDLQVGPAHSLFSLDYLKDMNKAIPSNTEVTLALGEEFPVKIYFGFAEGNGQVTYMLAPRIQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1J1</accession>
    <name>A0A3N6M1J1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV pilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88961">
        <property type="protein sequence ID" value="RQG88961"/>
        <property type="gene ID" value="EA462_11265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012859">
        <property type="entry name" value="Pilin_N_archaeal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07790">
        <property type="entry name" value="Pilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Pilin_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="139" mass="14503" checksum="F22B91E1FB2220BD" modified="2019-02-13" version="1">MNGKQIRNKLVGSEEERAVSPVIGVILMVAITVILAAVIAAFVLDLGGSVGQEAQAGVSMEVDNNDGEVQVEVSSIGNSDHVEIGGDADFDENLNVGDVQVLNNSEHDLGTNGTVTAIAVINESDTRTQVASESYDFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1R6</accession>
    <name>A0A3N6M1R6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">M67 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_11665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89031">
        <property type="protein sequence ID" value="RQG89031"/>
        <property type="gene ID" value="EA462_11665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="169" mass="18388" checksum="BE9BA12DE7D0FD6A" modified="2019-02-13" version="1">MTSDADSERPAGPPAPTLVVPASIRDAIVGRARDGRPAEICGVLGGEFDADRARVRSQYPADNAAETPRTRYRIDPQQQLSIFDRLEGRGEEIVGFYHSHPTGPPHPSATDAAMATWPDRSYLIVSLEPFELGSWRWCSGTKRDGSGATDDGAAVDDCGAFERERLVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1W5</accession>
    <name>A0A3N6M1W5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
            <ecNumber evidence="2">2.5.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folP</name>
        <name evidence="2" type="ORF">EA462_07105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89780">
        <property type="protein sequence ID" value="RQG89780"/>
        <property type="gene ID" value="EA462_07105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="397" mass="43080" checksum="F6D78EE834F8B649" modified="2019-02-13" version="1">MNTVDAAGLEIGDGHPPRIMGVLNVSEESPYDPSVYDDPGEAAQYVDDELISEGADIVDIGLESANKRFEVLSADEELERLHLALETIESVSGDAVFSIETRYASVADEALSMGFDMVNDICGFADPAMPTVCSERDAAVVKMASPPDLERPGAVGATDWSTRRSPDWAKRASYVDQVYEALKQNGLTGRTIIDPAFGGWSQTQTLEDDRETFRRLREFRALGQPVLVSINRKNFLGEIADRETDARLPVSLAATGLAVERGAHVVRTHDVAETRDAALIGSEFRTRSSASEGGVTVSELEIDSLRTFRAHLGERGIDPDVAADWQTRVLEIDGLAEQSIDRLVAETVGPDATVYRTPDDSVLFIGTPGGLSEVRARIEAETEQTGQLIEVLGKMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M240</accession>
    <name>A0A3N6M240_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gas vesicle structural protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_07545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89860">
        <property type="protein sequence ID" value="RQG89860"/>
        <property type="gene ID" value="EA462_07545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="99" mass="11165" checksum="87DB03DE76AA7A31" modified="2019-02-13" version="1">MRPRKDDEALVDVLDVVLRDGAILRADVIVSIADIPLVGIKLTAAIAGMETMTEYGLFEEWDVERRRSTITRRQYGRRDALESDRTGSVTVGSRNREET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M284</accession>
    <name>A0A3N6M284_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89221">
        <property type="protein sequence ID" value="RQG89221"/>
        <property type="gene ID" value="EA462_12715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="523" mass="58645" checksum="47645A060B39AA90" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2J9</accession>
    <name>A0A3N6M2J9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gfo/Idh/MocA family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90040">
        <property type="protein sequence ID" value="RQG90040"/>
        <property type="gene ID" value="EA462_08550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="141"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="394" mass="43304" checksum="4BA05C15A869886B" modified="2019-02-13" version="1">MTLSVGVLGYRFMGKAHANAMARLPMFFPDAPAIDRHVLVGRDERALSEAADRLGFASISTDWEAVVDDVDVFYNLGPNHVHAEPSIAALEAGTPVFCEKPLAPTLEEAERMIEASREAGDDVPAGCAFNYRFVPAIRYAKGLLEAGELGEIHHVRGRYLQDWLVDPDAPWSWRNDKELAGSGALGDLGAHTIDLVRFLVGSDDLAGEIERVSGHLQTFVEERPVEGAGTSAEPRATEDDKAVERDDTRPVTVDDAYTAQLAFESGAMGTLEASRFATGHKNDHTIEIHGSEGSLRFSLERMNELEVLRGDARGYETVLVTDEDDPYVDHWWPPGHVLGWEHTFVHENYEFLSAVANGTSFEPSFEDGLAAQRVLAAIETSDERRTWVAPDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2L4</accession>
    <name>A0A3N6M2L4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_08655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90060">
        <property type="protein sequence ID" value="RQG90060"/>
        <property type="gene ID" value="EA462_08655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="7"/>
            <end position="257"/>
        </location>
    </feature>
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        <location>
            <begin position="352"/>
            <end position="606"/>
        </location>
    </feature>
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        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="6">
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            <begin position="398"/>
            <end position="405"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG90060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="702" mass="77641" checksum="5602D71F8D99E0F3" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M354</accession>
    <name>A0A3N6M354_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86113">
        <property type="protein sequence ID" value="RQG86113"/>
        <property type="gene ID" value="EA462_17325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
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        <property type="entry name" value="PTHR31970"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
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            <begin position="20"/>
            <end position="41"/>
        </location>
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            <end position="69"/>
        </location>
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            <end position="108"/>
        </location>
    </feature>
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            <end position="138"/>
        </location>
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            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="367" mass="36464" checksum="A68115A516330D72" modified="2019-02-13" version="1">MAYSFGNSTRSELEFSVSELTGALGDSVTVLPLIVALAATTTVSLPHVLIGFGVFQIVWGVYYGMPLSVEPMKALVGLAIVGSLSYPELAAAGLLAGGVLLAVGSLGLVDRLQRIVGEPVIRGVQFAVALLLLEAAIGLSAGNLSVAAGGLAVVVVLALVGYRHSSILAVLALGGIAAVISTGFPTPRLPELALFPAGSPTVSVAALEGTVAQLGMTLGNAAIATALLCGDLYDRDVSADSLSKSMGVTCLAAIPVGGVPMCHGSGGLAGKYAFGARTGGANVLLGVGYLALALVAAGALLAAFPMALLGVLLAVVALELGRAAFAPIDDGWVLALVVVVGVVGLAINVGIAFVLGAVAFWLRSRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3P6</accession>
    <name>A0A3N6M3P6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagella accessory C family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86747">
        <property type="protein sequence ID" value="RQG86747"/>
        <property type="gene ID" value="EA462_16565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Arch_fla_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009205">
        <property type="entry name" value="FlaC_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04659">
        <property type="entry name" value="Arch_fla_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05377">
        <property type="entry name" value="FlaC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arch_fla_DE" evidence="2">
        <location>
            <begin position="370"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="691" mass="74275" checksum="EADD177B29627F39" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3P7</accession>
    <name>A0A3N6M3P7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89831">
        <property type="protein sequence ID" value="RQG89831"/>
        <property type="gene ID" value="EA462_07380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="116" mass="12959" checksum="D1864A6F5D7F2D02" modified="2019-02-13" version="1">MSHPDTTPTESAGILSALGSKYSAEILCAAGTPKSAQALSDDIEIPIATCYRRIEELVDAGLLSCEGRQLSEEGRRTNIYRRTLDELEVDFADTRPRFSRKRRTEAKNQLQDQLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4A3</accession>
    <name>A0A3N6M4A3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_15165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86987">
        <property type="protein sequence ID" value="RQG86987"/>
        <property type="gene ID" value="EA462_15165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="554" mass="59052" checksum="DDBD1C6470387E48" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4F3</accession>
    <name>A0A3N6M4F3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90111">
        <property type="protein sequence ID" value="RQG90111"/>
        <property type="gene ID" value="EA462_08940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="300" mass="32022" checksum="8A7E9292284A2E5D" modified="2019-02-13" version="1">MATAEDDDNADETGGVGSTGEDRCTRKKCVLITGCSSGIGRATALAFLEENWQVIATARNVDDLTALDEAGCTTLELDVTDHDQITRVVERTVEIGGAIDCLVNNAGYAQLGPLEDVSTVDLHRQFDVNVYGPHRLIRAALPHMRAQGDGRIINISSVMGRLSLPGSGAYSGSKHALEAMSDSLRGEVEEFGIDVVVIEPGTVETNFEERTAEELPGAERTPAYGTLYEIIGDVQLIGGGNGGPFASDPEDVARAIIEAGTHPEPPARYPVGPLGRFGVYARFLPDRLRDAGYVLLRKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4G3</accession>
    <name>A0A3N6M4G3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90121">
        <property type="protein sequence ID" value="RQG90121"/>
        <property type="gene ID" value="EA462_09015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="212" mass="23789" checksum="7A5FE4B70FAF2936" modified="2019-02-13" version="1">MTVDPFNRGKHHGAVVVGSLALASLLWAVGYPFSRIVAAIPWFLLFLVMIIGPVTKIWPSISRRYSGNFPLNWRSELGIWFVGWSLAHVALVFRSMGWDVVGFVVGMSAWAFAATVGVIIAVILAITSNNVAYQYLGPKAWKWHQSHGTYVMFWLLTVHIYDQTFLRGGVPPEDPLHLLYVATILVVVGLHIWAFLTVVFHYRTHGSYPPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M561</accession>
    <name>A0A3N6M561_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">M42 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_03910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91150">
        <property type="protein sequence ID" value="RQG91150"/>
        <property type="gene ID" value="EA462_03910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="355" mass="38285" checksum="8BAA16FDEC63705E" modified="2019-02-13" version="1">MTATPFDLDRLEELTETSGVPGYEDRVRELVVRAFEESVDRVRTDAMGNVVGTLEGESDYSVAVAAHMDEIGFMVRHVRGDEDGFGFLELDALGGWDARVLKAQRVTIHAEDGDLPGVIGSPPPHTLDEEDREKIPEVEDAFVDVGLPYDEVTERVSPGDLVTMNQTTKLVGETITGKALDDRVCLFAMLEAARRIDDPAVTIHFCATVQEEVGIRGARALGVDVDPDLAIALDVTVANDVPGFKRGEHVTELGEGTAIKLKDSSVITSPKVHRRMTAVAEEAGIDCQLEILPAGGTDTAGFQHTAGAKPVGAISVPTRYLHTVTETAHVDDVAATIDLLEAFLETEDGEHEYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5F3</accession>
    <name>A0A3N6M5F3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91250">
        <property type="protein sequence ID" value="RQG91250"/>
        <property type="gene ID" value="EA462_04465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="31"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="321" mass="36060" checksum="AFF387B1D9F26745" modified="2019-02-13" version="1">MGSVVLSLDAELGWGFHDFESPPVDRVEAGRRGWSVMLELLEEYDVPATWAVVGHLMLDSCDGTHADHPAPPGWFAPERTEWRNRPDLRFAPALVEALFDSDVDHEFASHSFSHVLFGDPETDRELAAAELDRSMDIAADWGRTIESFVYPRNDVGHRDVLAEYGFGVYRGKSPTHDGVRGLFDSIVRSRSMLVEPAVDEYGLVNVPASLFLFGFEGPARTAAESVWADPMVVQARLGIDEAARRDGVFHMWLHPNNLTDPRDDERMRAILEHLDRRREETDIRVETMGETARRLENGRTVDGRVPSVEYDATELSSTPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5J8</accession>
    <name>A0A3N6M5J8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91300">
        <property type="protein sequence ID" value="RQG91300"/>
        <property type="gene ID" value="EA462_04750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="267" mass="27388" checksum="0CEC0B634C1CE2D4" modified="2019-02-13" version="1">MRLEAESATVREWVSAEYADIVLAVIFWLAGSNRRQSALVISYALGGMAFLLTVKTVLAVPRPPESALLVPLEVSGYGFPSGHAFAAVVVYGGLCTAFDRVRHPPSLVAVAAIVALVSLSRVILGVHYLGDVIAGALLGVVVLFAMDRLTAGDPRTGFVIATVLAVPAAFVTGGSESALIGLGSSLGGLVAVRWLSALPALRSALEGVVLVAVGLCGLFVIRTVAAAAPTDSLFVVMYALLVCWVVLVPAGVGRLPIAALETSSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5W7</accession>
    <name>A0A3N6M5W7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginase</fullName>
            <ecNumber evidence="3">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rocF</name>
        <name evidence="9" type="ORF">EA462_05465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-arginine = L-ornithine + urea</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91420">
        <property type="protein sequence ID" value="RQG91420"/>
        <property type="gene ID" value="EA462_05465"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="PTHR43782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="306" mass="32631" checksum="C48975F9F1A050A8" modified="2019-02-13" version="1">MDSTVRIIGVPMDYGADRRGVDMGPSAIRYGGLGTELEDAGVEPVDGGDLFVPRAEERDPDAGSPRRGNAKFLREIEDVCTRLSDRVADAIGNGEFPLVLGGDHSVSIGSLRGSSRDADLGVIWFDAHADLNTPETSPSGNVHGMPLSATLGRGMFGEMEWANASGVREDAIAYVGLRSIDERERKRVRESELTAFTMSDIDERGITAVVEDALSVATDGTDGIHVSLDLDWLDPTTAPGVGTPVRGGVTYREAHSALETVSRRHDADGLIRSMDVVEVNPILDERNETATVAAELAASAFGKQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7J6</accession>
    <name>A0A3N6M7J6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91311">
        <property type="protein sequence ID" value="RQG91311"/>
        <property type="gene ID" value="EA462_04820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="70" mass="7597" checksum="69104D0CAF137AE2" modified="2019-02-13" version="1">MSDLAALLFNAFLVVQVPIALLVYVDARRLALENPLVYVFGILVPAGGIIVVPIYVSRRDDLPRSGDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8P4</accession>
    <name>A0A3N6M8P4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89836">
        <property type="protein sequence ID" value="RQG89836"/>
        <property type="gene ID" value="EA462_07405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="127" mass="13708" checksum="06E2ECFF2548ABCB" modified="2019-02-13" version="1">MLVFASAPQLIAPFSESDAADPLRADRVATDLAESTFVDTPSSTQINTTAATAFFDEPDDVHTTVGLDTRTPLNISVVSTESGEPLSSNGVEYTFGEPVPERAGQVSVTQRVLQVDDESYWLSVRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9K7</accession>
    <name>A0A3N6M9K7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90206">
        <property type="protein sequence ID" value="RQG90206"/>
        <property type="gene ID" value="EA462_09470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="299" mass="31902" checksum="7EB36F3A926507D1" modified="2019-02-13" version="1">MQFVEEIVVDEFLPTVRSMLATALRERGLTQSEVAQVLGISQSAVSKYAHGDVTTNDRIAGDERIEALVEELADGLASGDVTPVRALIEIEVLVRELETGGDVLAQLHEEAVPELADHGSSFRVHDPENDLRTSERVLSSLRRGLRILENASGFASLIPAVGSNLVACTPDADDIDDVAGVPGRIFDVKGQATVPTDPEFGVSEHVATILLASRRHDAPVSAAINIAYSPELLDRLVESGHTAAEFDESNDIVSSVGAAVENEPEATVLYQTGRMGIEPLIYVLGSDAESVADDVRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBT8</accession>
    <name>A0A3N6MBT8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91136">
        <property type="protein sequence ID" value="RQG91136"/>
        <property type="gene ID" value="EA462_03830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="9531" checksum="FAEEF16F29BDC509" modified="2019-02-13" version="1">MSTQATSSGQHSSPKAQRLATYLRNELERQSGELYVKGKFIANDVDLSPKEIGALMLKLQGTVDDIEIEKWSYTSATTWRVTEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBY7</accession>
    <name>A0A3N6MBY7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91196">
        <property type="protein sequence ID" value="RQG91196"/>
        <property type="gene ID" value="EA462_04185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="275" mass="31425" checksum="8A152249A8B6CCC3" modified="2019-02-13" version="1">MESSIEEIEFIASSKHRVGVLEALTEGDHDRGDLKSRTGAHSSTIGRVLSDFEERRWIERNGPTYELTPLGEFVADQFADLCDAMDIEGKLRDVWQWLPREMEGFSPELFADAVIAYPPTGYPYEPLERVIQLYEENNSLRGFGSTIFKGAAYEVFTREALDGMETEFIYPATCLSAIINWNPELFQQTATLEHCNILVHDDLPDRRRCGIDIFDDRVAICCHDPETRAFRAWFDTAAPEAREWAKSVFQEYRSEARPVDEEVLATPVPEQFTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC19</accession>
    <name>A0A3N6MC19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low molecular weight phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93031">
        <property type="protein sequence ID" value="RQG93031"/>
        <property type="gene ID" value="EA462_02120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="11"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="149" mass="16792" checksum="F916D6275E6CE427" modified="2019-02-13" version="1">MSTTTEPTDAIRLAFVCVRNAGRSQMSAAIAERERDRRDLAGRVEIRSGGTDPADRVHETVREVMAADGYDCSDRVPREISPEELRSCEYVLTMGCSTLDIEDADAVDVRDWALSDPHGRDPTEVRRIRDEIERKVNALFDEIERALEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC84</accession>
    <name>A0A3N6MC84_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93101">
        <property type="protein sequence ID" value="RQG93101"/>
        <property type="gene ID" value="EA462_02540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="205" mass="21640" checksum="67611D1C7A9B2422" modified="2019-02-13" version="1">MGEIVGIVLAGGLGTRFEDGNKLLATVDGEPVVRHAARTLAVPAVEYTIAVLGHDARTVGQAVSADVEETVSNPDFAEGQSASVRAGTRAARERDADAAIFLPGDMPRVDPETVTRVVETYRSDGGEVVVPSFDGKRGNPVLFDGTCFAELLELSGDTGGRALFDAADVRRVAVDDPGIHRDVDTVADRARLDRLESDGTDPDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGS3</accession>
    <name>A0A3N6MGS3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93176">
        <property type="protein sequence ID" value="RQG93176"/>
        <property type="gene ID" value="EA462_02950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="121" mass="11615" checksum="32536F5AB3FC583A" modified="2019-02-13" version="1">MSVKTGTIALVAGLAAFFGVGIGVTAITEHWIDFPLLLGLLAGTLSGLVATIAVTVGLESDVSAGRRRTAGIVTGFGGGFVCGLLIGAAAEPIGTVGSIGVGAGVGLLVAGGYAVSPFGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MH23</accession>
    <name>A0A3N6MH23_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93296">
        <property type="protein sequence ID" value="RQG93296"/>
        <property type="gene ID" value="EA462_01685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="250" mass="27156" checksum="3D5FE2FF72D3E0B0" modified="2019-02-13" version="1">MNPVRVDAAVDLAYGALIGLSILLILLVGTNVGIAFGVGVFASYVVHVVWKMARFDPDWMTTAVQESVEESVGETVEKTVGETVEESVGETVEAKVSETVEESVGETVEESVGETVEAKVSETVEKTVGETVEESVGETVEAKVSETVEESVGETVEESVGETVEETVEKTVGETVEEAVERTVGRQLEEMQAEVQAVEDRVDRRPREDEVEQLIDSSIDEGSDRDDEEAARDDEEAARDDAERSDHNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MST2</accession>
    <name>A0A3N6MST2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ParB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87815">
        <property type="protein sequence ID" value="RQG87815"/>
        <property type="gene ID" value="EA462_13165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="118"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="241" mass="27094" checksum="34CC819B68924A0E" modified="2019-02-13" version="1">MSGTTRNEIAIDEPPFEAGDIVVDREDDSPSEAIVVNVPPIVATEWTVNGRGPLASDNPTYPADDRVVIVIYRTTLDGEYPYYTGGYPIPLERSNQDDVTTYAFPSQRLRRVGTLSPIEIQISSIDPSPYHARNFTTAQNGDFVAEITERGYPDPAPLVRRCDGRFEIVNGHKRIWACHVAGFETVPCHCAYLDDETATRLWARWHLDTYDRAERSAARHRIRSTLGSRADEILEDVTPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTT7</accession>
    <name>A0A3N6MTT7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF541 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88792">
        <property type="protein sequence ID" value="RQG88792"/>
        <property type="gene ID" value="EA462_10325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="256" mass="27395" checksum="EB6300B79FB90F06" modified="2019-02-13" version="1">MDRRQFLAASTVGVTAAMAGCMDRALGSDEGERSDRGTTGAASGDAVDREITVSANGEVETEPDRATLSVGLEAEGSEAEEVTNELAERAEALRDALDELGIPDEHVEEGQYRVHPRRGDGDGFEGTHTFQIELDDVERVGEVIDALVEEGVDNVGRVNFSLHDETEAELRDRAIDSAFENADEEAMYIAQNRDVSLAGIVSVSTTNVDTVPVRYDARDVVAEDDVAASAAETEIDADPVTVTASVEVVYGFENRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUP4</accession>
    <name>A0A3N6MUP4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5611 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89122">
        <property type="protein sequence ID" value="RQG89122"/>
        <property type="gene ID" value="EA462_12175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040713">
        <property type="entry name" value="DUF5611"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18446">
        <property type="entry name" value="DUF5611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5611" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="127" mass="14438" checksum="8F12D5C08D6240D1" modified="2019-02-13" version="1">MKEYKMRRGEYLEERIPDMESTVEDYFGTITETQEYKGSDLHVVGEPANPVFEKIVVGAVEYSGKKDKLGVEFYERDPTELGPDELEAAGEAVDAKNDFLLEATGRDAKSRRDSMKRTVEDDPDHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUZ1</accession>
    <name>A0A3N6MUZ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_12720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89222">
        <property type="protein sequence ID" value="RQG89222"/>
        <property type="gene ID" value="EA462_12720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="339"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="487" mass="52508" checksum="158E484C1AF39DF6" modified="2019-02-13" version="1">MTGTGTLVSRFKIELLGQLVAAVSGALLLVSLARFLEPEAYGLLFLSISIFTILMVATKLGIGRSAGRYLSEYKDTDPAQIQHIILTSLLLNLSTVVVVGLGLLLGYRLLAELLGEPELAPLLALGVLYVVFGTLTKYVRLVLQGFEAIESAAAIHAIDRGGRLLFAIGLVLLGYGSIGALGGYILSYVVATLVGLAWIYSRYYRPFRRDVPIESGLRRRIAEYTLPLTATSTANVIEKQVDTVLVGFFLTPVAVSYYVISKQIVEFVEKPATALGFTLSPTLGAEKADDNLDHARDIIEVALEKSLLLYIPAAAGLIVVAEPTVLHLFGEKYADAIPVLQILGIYTVFRVITNTVGHGLDFMGRARERAIVKGITAALNFVLNILLIPRIGVVGAAIATVSTYGLFTVANLYLVHTELGLRTGYLLKQFVLISSITLVMSAIVFFSLAYVSGLLTLLSVIAFGTFVWGTLSISVGLLSSREIRSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWU8</accession>
    <name>A0A3N6MWU8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89962">
        <property type="protein sequence ID" value="RQG89962"/>
        <property type="gene ID" value="EA462_08110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="136" mass="14966" checksum="D852E6AD1E5AB5A7" modified="2019-02-13" version="1">MPVESDVELRDVLSHETIAVVGCSSTPGKAAHDVPLYLDERGYDVIPVNPFADEIFGRSVPDTLSDVDEGVEVVCVFRPSEEVGGIVDGSLEREDVEAIWMQQGIRDDEAAARAEDDGRTVVQNRCMKIEHRRLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MX43</accession>
    <name>A0A3N6MX43_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_08665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90062">
        <property type="protein sequence ID" value="RQG90062"/>
        <property type="gene ID" value="EA462_08665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="315" mass="35511" checksum="5DDC43DDA626FC74" modified="2019-02-13" version="1">MSWSQYAIKRTLSSLFVLFGASVVIFSIVRLIPGDPAQVLLGDTAREAQLEVVRRELGLHRPVWEQYFIWLSDVLTLDLGRSYMNNQLITELIAIRYPRSLQLAIFTMIFASMIGIPLAIWGASNRNSSRDYLALFFSQFGVSIPSFFLGVVLILLFANYIPLFPPSGYMSFFDHPLGNVVHLFLPVVTLTVINAAIITRYLRSEMLENLNSEYVQTARAYGHSERRIILKYVAKNAMIPTITVIGIQFGGIIGGVVIIEEVFSYPGIGLLLLDSILRRDYPVIQISLLAIAATFIFVNLIVDLIYGYLDPRIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXD0</accession>
    <name>A0A3N6MXD0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubrerythrin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90162">
        <property type="protein sequence ID" value="RQG90162"/>
        <property type="gene ID" value="EA462_09240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="211" mass="22995" checksum="8533D4ABA63E0957" modified="2019-02-13" version="1">MTSSDAFLETVREENQTPLSRLGSSKSLYADTGGDIDTEPVLEATADAEHAAWQTFLSWADSEEYEAARDAFETTAEEEREHFEAVVDHLGDDDYEPQAVPALHDYLRSLGSTPERVGAFVGRILASKRSKEQVVGYFVGDADPQTASVFRGFGSDLDDQLERATDLLSAVCESDDDRERALEAATGAIEAAYGEYVENLEAMGANPKPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXL1</accession>
    <name>A0A3N6MXL1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2797 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90252">
        <property type="protein sequence ID" value="RQG90252"/>
        <property type="gene ID" value="EA462_09740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021246">
        <property type="entry name" value="DUF2797"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10977">
        <property type="entry name" value="DUF2797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="250" mass="27625" checksum="B878FB49C5A420F1" modified="2019-02-13" version="1">MQLVGYEPSGRGSALLVSNGGSIERRVIEPGDRLTYALGSRRCAGVIDDGTHLACERSAAPYCDFHTSTWVCARCTGTCLKDEMDCYEEHAVYLAAFAPETFKVGVTRRRRLETRLREQGADRAAHVHTVSNGRIARQIEAEIARRLVDRVRTDAKVASLASRVDEDAWLDVLTSFDVIDRFDLEYGFDVETRPVRETIATGIVVGLKGRLLVLENGGTTYAVDMRDLVGYELETGETDRNLQSSLGSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXQ9</accession>
    <name>A0A3N6MXQ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90312">
        <property type="protein sequence ID" value="RQG90312"/>
        <property type="gene ID" value="EA462_10065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="85"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="250" mass="28251" checksum="FF9276BC2CB41316" modified="2019-02-13" version="1">MRIENSFIPVRGVGETTERRLWEHGITHWDEFDGSVVGETLAGRIESFIDEGWDHLDRGDVSVFADRLPAASRWRLYENVRADTCFLDIETTGLDATRNDVTTVSLHRAGETKTLVNGRDLTGERLATELEDAALLVTFNGQRFDVPFLETCYDLDVSVPHLDLMYPCKQIGLDGGLKAIEGQLGIERDLPDIDGREAVRLWHQYERGDDAALETLISYNRADTKNMKPLLETVTNRLHDRVFEAACATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0X0</accession>
    <name>A0A3N6N0X0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_06415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91582">
        <property type="protein sequence ID" value="RQG91582"/>
        <property type="gene ID" value="EA462_06415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="5">
        <location>
            <begin position="12"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="101"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="363" mass="38955" checksum="2B1467C22AD41C15" modified="2019-02-13" version="1">MSITEHELKIKLEGIEDPDIGDDIVSLGLINDVTIDDETARISLAFNAPYAPSEMELGNRIRELCDEVGLEADLRAHVGQEHGFDDEVLPRVRNVIAVASGKGGVGKTTVAANLAAGLEKRGAMVGILDADIHGPNVPRILPIESEPGVTPNEDIVPPRSDGVRVISMGFMMEEEDDPAILRGPMVNKFMMKFLEGVEWGRLDYLIVDLPPGTGDATLNLLQSMPVTGSVVVTTPQEMALDDTRKGIQMFNKHNTPVLGVVENMSSFICPSCGDQHGLFGTEGADSIVDAYDVPLLGRIPINPDFGADGSTGAIVKNDESSAQEPVEALVAEISNRIGEINRRTVDEHTSDTPDDALPTDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4C0</accession>
    <name>A0A3N6N4C0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenol monophosphomannose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93022">
        <property type="protein sequence ID" value="RQG93022"/>
        <property type="gene ID" value="EA462_02075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="33"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="260" mass="29107" checksum="6454C35DE0070767" modified="2019-02-13" version="1">MSSADGALWKTRSESSSISDSAPLEPDIGRGLSVIVPTYNEAENVEHVISRIRNVLQGYEYELIVVDDDSPDSTWRIVDLLYGDDDRVRVIRRIDERGLGSAIAFGIARSRFEHCAIIDADLQHPPEVLPRLLVHVEDDVDLVIGSRYAEFGRITGWTTARKLVSKGAVAIAKALLPQTRSIADPLSGFFVINRSLLDGERVDPTGYKFLLEALVRCEPESVREVPYAFEDRKRGESKLSPREYLAFLEHVFSLRRAGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NTW7</accession>
    <name>A0A3N6NTW7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86116">
        <property type="protein sequence ID" value="RQG86116"/>
        <property type="gene ID" value="EA462_17340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="127" mass="14053" checksum="9453A1072A71C16E" modified="2019-02-13" version="1">MNSSNETAADVRRTLERLSDDCDPVAELEERRPDDETVATQETVFGALANAHRIHALEALRDGELCACELQIVLDAPQSTVATHLRTLRDAGLVKTRKKGKWTYYRIADTAVFELLDVAAAVETPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUQ1</accession>
    <name>A0A3N6NUQ1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Regulator_TrmB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86910">
        <property type="protein sequence ID" value="RQG86910"/>
        <property type="gene ID" value="EA462_14720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulator_TrmB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="28180" checksum="83C07D2796CD76F1" modified="2019-02-13" version="1">MGTQTYENVYSRERALSELREQIHESREIVALAAPIELIPQIEDVLTEAVDRGVLVLLLLASDDLSYEEAAQRAFPATIVRYWEPQGVNVTSAMVDYHSGLVTISQLHDSDADVGRTLIYADEFFGNMQLTSLVVNFWRRGDEIYADDPLPLPHTYDSFFYAIIDAAKRLRDRHDLYATVSVVGGHPEYGEVIGGPVINVRQNIVFPMTNSFPAENNMFVESNHGTVSVGGPSGTVEDIGASAVKLYEGDVTPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWS2</accession>
    <name>A0A3N6NWS2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA carboxylase biotin carboxylase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_11595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89019">
        <property type="protein sequence ID" value="RQG89019"/>
        <property type="gene ID" value="EA462_11595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="6">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="120"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="447" mass="49437" checksum="83DCA70C810D395A" modified="2019-02-13" version="1">MFDRVLIANRGEVAVRIVHACTELDIDAVAVYSDADEEAKHVRVADEAYYLGGSQAKKSYLNQDALLDVARLADVDAVHPGYGFLAENQSFAANVEESEFAWIGPPSSVMADFGEKTSARTIMKQADVPIVPGTTEPIEAPGAVEAFGEEYGYPVAIKADGGGGGRGLKIVHKPSQTESKLQDAVREGEAYFDNPMVYLERFLENPRHIEVQVIGDGHGTVRHLGERDCTIQRRQQKLVEESPSPVLDEEVRDEICEAARRGVAEASYENVGTVEFLYEDGEYYFLEVNARIQVEHPITEVRTGIDLVKWQIRVAAGEKLSFSQDEVDPRGTAIEFRINAEDPDNDFTPLPGTLSTFRPPTGIGVRVETGVDQGDSIAPFYDSLFAKLIVTGEDRDEAIARGKRALEGFDIEGIPTTIPFHRTLLEDRGFLENEHTTTYVERELLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYY3</accession>
    <name>A0A3N6NYY3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">dCTP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90089">
        <property type="protein sequence ID" value="RQG90089"/>
        <property type="gene ID" value="EA462_08810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="152" mass="16664" checksum="4CCFCDA8688BB663" modified="2019-02-13" version="1">MSAEHPLVECIDNLVYEPTQVHEHGIDLTVSAIYEVAAPGRIDFGGDELEDADLEPVPTSLRSPDDEFGWWELEGGQYVVQHNEFLTDAERTLQLQPRNELLARGVSHPSMLVASHLPLVPISVAGGGVKIKENARISTLVSTDSPEPSENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZH4</accession>
    <name>A0A3N6NZH4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90359">
        <property type="protein sequence ID" value="RQG90359"/>
        <property type="gene ID" value="EA462_08015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="145" mass="16112" checksum="2A9084C39AC19E8B" modified="2019-02-13" version="1">MIGDPIDILLVEPNPGDTRLFTETFEEAKVMNAVHDVSSGEDALDFVHQRGAYEDSPRPDVILLDPQLPGKSGMDVLAELNDDPELCETPVVVLTSSEVGEKIIRSHGLEADTYIQKPVEVGEFVEFVQSIEDFWLAFVQQPTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZW5</accession>
    <name>A0A3N6NZW5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR00269 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87136">
        <property type="protein sequence ID" value="RQG87136"/>
        <property type="gene ID" value="EA462_15540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00269">
        <property type="entry name" value="TIGR00269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="56"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="319" mass="35631" checksum="BCB9930C53443E12" modified="2019-02-13" version="1">MDCNRCGEEAVMHAAYSGAHLCADHFRESVTKRIRRRVRRDDLVSGDPTPEDPQIWVIGLSGGKDSVVLTQILHDTFAEDPRIELVGLTIHEGIEGYRDKSLEACVELTDDLGIRHEVVSYESEFGVRMDDVVEDDPENMAACAYCGVFRRDLLSRYAEDLEADLLLTGHNLDDEAQTALMNVLEGDVAQIAKHFDASLGPLSERDEQDEFVPRAKPLRDVPEKEVALYAHLDDLPAHITECPHSSEAYRGEIQQLLYQLEENHPGTRHSIISGYEELAGIVSEEYSGDDGADLRECIECGSTTTREICRKCSLLESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0D4</accession>
    <name>A0A3N6P0D4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87908">
        <property type="protein sequence ID" value="RQG87908"/>
        <property type="gene ID" value="EA462_13680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="27934" checksum="CA4D3E8D25F93647" modified="2019-02-13" version="1">MATEYTSRELMVTTAANEIRDDECAFVGMRLPLLAYQVAVSTHAPNSVAVFENGTVRDAPSDELIYTMGDLAHLDRSVSTTNMIDVMSRLQRGDVDIGFIGGAEIDRYGNLNTTRVRAGDRTIRLPGSGGACDISVLSDRTVIIMPHEPRRFVEEVTYRTSPGHGTGGDWRAAEGLRGGGPDALITTKGVFRFENGELTLSSVHPGVSVDEIHESIPWELRTAADGDEEIETTPEPTPTELEYVREFDPDGFWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P184</accession>
    <name>A0A3N6P184_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="18" type="ORF">EA462_10450</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88815">
        <property type="protein sequence ID" value="RQG88815"/>
        <property type="gene ID" value="EA462_10450"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="17">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="16">
        <location>
            <begin position="167"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="15">
        <location>
            <begin position="322"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="183"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RQG88815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="451" mass="48271" checksum="791082CDC02A6C35" modified="2019-02-13" version="1">MIPAGIVAAGRVTHRSAGVDDLAAASPESQRAGVRKLCSIPEIDEAYVLSTCNRIEAYVVAPDAAVGRAALEGFFDGTDDEAIVETDHDESLRHLLRVAAGLESVVVGEDQIIGQVRTAYEDARSVDGIGTMLEAAVTKAIHVGERARTETEINEGVVSLGSAATQLAARDVTLAGATALVVGAGEMGRLAVRSLAGADIDELVVANRTVSHADHLASEVDVDARAVPLPALSTVAADADVVVTATNSTDPVLEVSHLERNERGPDNGVVGEGDRTVIVDLGQPRDVAPAAGSIPSVTVYDLDDLESITEETREQRADAAREVETMIDREFELLCEQYKRARADEVIAAMYESADRIKERELETAYSRLEDEEFSPAQREVVDSMADTLVSQLLAPPTKSLREAAAEDDWSTIHTALQLFDPHFEGEMPFTPASFEDRTTADTRLRSVDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P197</accession>
    <name>A0A3N6P197_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91259">
        <property type="protein sequence ID" value="RQG91259"/>
        <property type="gene ID" value="EA462_04515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="199" mass="22067" checksum="94413C5087D9B0EE" modified="2019-02-13" version="1">MSSIDTSLPDEIASSVSDSADEDGLSKDVIFELLKNRRRREVLAYLLEAEETVTLGELAEQIAAWENDTEVNALSSDQRKRVYVALYQTHLPKMDDAGIVEYDQDRGLITLSDNADLLMMYLDTDTHHQDRWDRWYSVLSVVGAALITGTFLGVPPLSVLPTIAIAGAVVVAFFVLSIVHAVSNRERERTVDGKLSRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1A3</accession>
    <name>A0A3N6P1A3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88845">
        <property type="protein sequence ID" value="RQG88845"/>
        <property type="gene ID" value="EA462_10615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="79" mass="9082" checksum="AC0227D1DFFDD190" modified="2019-02-13" version="1">MSLIGETKQSILLRLREEPAHGYDLAKELDISSGYVYQHLQELQDEGMIEVYEDETEGRQRTSYHLTENGELLLKALGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1Z0</accession>
    <name>A0A3N6P1Z0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89135">
        <property type="protein sequence ID" value="RQG89135"/>
        <property type="gene ID" value="EA462_12245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="196" mass="21544" checksum="D2081B70DE7744B3" modified="2019-02-13" version="1">MEVGLLYSGGKDSTLAALLLEDFYDVTLVTAQFGISDDWKHARATADATGFAFERLELDAEVAHEAVAMIRDDGFPRNGIQHVHQHALERAAADGFDVVADGTRRDDRVPTVSRAQAQSLEDRHSVDYISPLSGFGRGAVDQLVDAHLEVTVGPSEEIRRADYEAELRALIVDEDGLDAVGDYFPDHEQTYVTDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P258</accession>
    <name>A0A3N6P258_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91649">
        <property type="protein sequence ID" value="RQG91649"/>
        <property type="gene ID" value="EA462_06790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043825">
        <property type="entry name" value="DUF5802"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19118">
        <property type="entry name" value="DUF5802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="136" mass="15202" checksum="A106C3C81385A935" modified="2019-02-13" version="1">MFEVFSGSYYLGRLYVTPTNAESAFMHSDQHERINEEVYATGHGVERLDAPLVMKLENRHFPVHGDDAVPSDTLAVPETMLEETRIRNPPSLREVFLARRERARQLLEFAGGWQPSGDDSDATTGSSSDDYPNAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3K4</accession>
    <name>A0A3N6P3K4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89885">
        <property type="protein sequence ID" value="RQG89885"/>
        <property type="gene ID" value="EA462_07685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="92" mass="10269" checksum="B8E2412DE161F1B6" modified="2019-02-13" version="1">MGDDTAEWMDPADEAILEAMRSDDVFSPTHIDEEGICRGPYAAHRCRQLTEHGLLKKYTTGMYAITERGERFLAGELEASDLTSDEVASDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4N8</accession>
    <name>A0A3N6P4N8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90385">
        <property type="protein sequence ID" value="RQG90385"/>
        <property type="gene ID" value="EA462_09715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="119" mass="12335" checksum="B9770F1489D9374B" modified="2019-02-13" version="1">MSDENESNGDDGEEKSFRDRVEEIREKRAEEGEGEPPESPFGGGGGGPGGMGGGGNPFAQMMGGMMGGGPGGPGGAPGPGGRGGEESNEELVREVRQLRDEMRDQTRAIKRIADALEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P646</accession>
    <name>A0A3N6P646_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps2</name>
        <name evidence="8" type="ORF">EA462_04180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91195">
        <property type="protein sequence ID" value="RQG91195"/>
        <property type="gene ID" value="EA462_04180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_A">
        <property type="entry name" value="Ribosomal_S2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023454">
        <property type="entry name" value="Ribosomal_S2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_S2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="PTHR11489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="269" mass="28804" checksum="19C33FA18CE6E0CC" modified="2019-02-13" version="1">MTDNDATQEGLDAAEEEIEEEPAEGAGPAAEPDEDVEPADAQPAEAEAGAADADAESATEDEDAGPTLDDDVMSDEEADLLIPVEDYLGAGVHIGTQQKTADMERFIHRVRTDGLYVLDVSKTDGRIRTAADFLANYAPEQILVTSSRQYGRFPAEKFAEAAGARARTGRFIPGTLTNPKYDGYIEPDVVVVTDPIGDAQAVKEAITVGIPVIAMCDSNNQLSNVDLVVPTNNKGRKALSVVYWLLANEVLDRRGAEPSYSLEDFESGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6H7</accession>
    <name>A0A3N6P6H7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_05330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91395">
        <property type="protein sequence ID" value="RQG91395"/>
        <property type="gene ID" value="EA462_05330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="3"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="293" mass="30364" checksum="0160C58A8EC756FA" modified="2019-02-13" version="1">MVRVVTAGHINWDVTLRVDSFPVADGEAVIRSQRQSGGGSAGNVAASLAGFGIETGLIGSVGDDDNGLLARQELEDAGVSLDRVCVVDGADTAVKYLLVDDEGEVAILGNDGVNEAIGPDDVDESGIRTAEHVHITGQRPETAAAIATAAHESDTTVSVDPGRRIADRNFTRTLEVADIVFANDRESAVLLEDHFGQSIGIDRFVVVKHGEDGAVVHAPNGSYTHAGFDVDPVDTAGAGDAFAAGFIARLLEGDDVERALEYGNACGALTASAHGARNAPSTEEISAFLGSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9E8</accession>
    <name>A0A3N6P9E8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_01120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92855">
        <property type="protein sequence ID" value="RQG92855"/>
        <property type="gene ID" value="EA462_01120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="9"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG92855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="458" mass="50003" checksum="CA0B1E3D5054110F" modified="2019-02-13" version="1">MSERDDALIRAEGVEKRYSTASGFLERLFRTGETVPAVDGVDLAVRSGETLGVVGESGCGKTTLGQVLVGLVEPTAGTVTYRDIDVTAPSRVERRTLRQDVQYVFQNPTASLDPRLPVDDLVREPLAVHDVVPGRRRGDRVGELLEIVGLDRSHAGRYPDELSGGQRQRVAIARALAVEPELLVLDEPVSALDAAEQARVLNLLADLQAAFELSYLFISHDLAVVEHVSDRIAVMYLGRIVERGPTGTLFDGDVHPYTEALLSAIPEPDPRWQGERIILEGDVPSPTDPPSGCRFHTRCPKVIPPTALDLEPETFRGVMRLRSRLERIEDADDFRESVHTSSTDAGEKAISTAIRERDAIPSTLRDSSAEEALSAALESIAAGDLEAARGRLASTFETPCESEEPALRPSTGSTSRGVPDRNDCRRDETGETHLVACHRFDDEFDDRSGKRPNSEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9Y2</accession>
    <name>A0A3N6P9Y2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93115">
        <property type="protein sequence ID" value="RQG93115"/>
        <property type="gene ID" value="EA462_02610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1180" mass="129516" checksum="92E846379B8CB1E9" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI31</accession>
    <name>A0A3N6LI31_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF552 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86934">
        <property type="protein sequence ID" value="RQG86934"/>
        <property type="gene ID" value="EA462_14850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012426">
        <property type="entry name" value="SepF_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019313">
        <property type="entry name" value="UCP019313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="13075" checksum="AA7C3355239539AE" modified="2019-02-13" version="1">MGLMSRIIGGNQSRTAEDYVELDLDDVSTESADASMQVHIAEVSGQADAIDIKEAVYDGDIVIADVTRLRTNDSTVEHVVDELRQVAQEVNGDIVRKGDDQMIITPTGVRIGREKLGQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJW1</accession>
    <name>A0A3N6LJW1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88858">
        <property type="protein sequence ID" value="RQG88858"/>
        <property type="gene ID" value="EA462_10685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="198" mass="22998" checksum="DBB2E5B7716D6A1B" modified="2019-02-13" version="1">MKIGSEYETDYWRHVILEYRSDHGRIGESVIHSHQAELENLRDDLLDRIDRLESNQTGMRDDPDFDQQDLNGLPDDTAIPRPYTYRLVALMALSCGIMEKQLEILLSQDLIPDKRRDGIVQSCFENRGLYKNLEFAKAANVIDDKVYSPATDVRKTRNRLVHNPVFRLHIDSYSSHRHRIKKAVKAPNEIDQLIQNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJX4</accession>
    <name>A0A3N6LJX4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88878">
        <property type="protein sequence ID" value="RQG88878"/>
        <property type="gene ID" value="EA462_10800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="66" mass="7420" checksum="B5A5A16A6A490883" modified="2019-02-13" version="1">MVPIHVSLSGHREGLVRTIPRSKPRHGWIARVHGDRPTRDRSPSARQFGTDGPDRTTRSNPSALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK59</accession>
    <name>A0A3N6LK59_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88958">
        <property type="protein sequence ID" value="RQG88958"/>
        <property type="gene ID" value="EA462_11250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="88" mass="9931" checksum="07ADF330087C6A59" modified="2019-02-13" version="1">MRTDDQGSVVVTGQRQIHWARSFRLSSFVLSDSDYSMATKPNFECPVCHQEIAVGEQLVDHLHHNHSKDTLAEFVATEAVAMEEEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKE2</accession>
    <name>A0A3N6LKE2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Precorrin-6Y C5,15-methyltransferase (Decarboxylating) subunit CbiT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbiT</name>
        <name evidence="3" type="ORF">EA462_12885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89253">
        <property type="protein sequence ID" value="RQG89253"/>
        <property type="gene ID" value="EA462_12885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="212" mass="22413" checksum="457CDF3BB36D4DC6" modified="2019-02-13" version="1">MAPIALPHDAKAGPTKPEVRAVVRSKLALTDEDHFAEVGSCTGAVTIEAAQQAGRVTALERKPGRLETTERNLAANEESIRADVELRNAEAPEGLPDDADALFLGGSRNFEAVLDHAVETEIDRVVMNVSRLETAGRALEAFRDRNVLEEVVQFQVSHGYELAGATSFDSDNPVYTLVGSATPEDGSENGGETAVADGGQVTDGTTAGGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKH2</accession>
    <name>A0A3N6LKH2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86928">
        <property type="protein sequence ID" value="RQG86928"/>
        <property type="gene ID" value="EA462_14815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="3">
        <location>
            <begin position="256"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="401" mass="45135" checksum="05AF85565BBD9882" modified="2019-02-13" version="1">MTTQRIPVTVLSGSLGAGKTTVLNHVLTADHGLEVAVVVNDMGEVNVDAEHVAQRSDLSDDDEIIELSNGCICCRLRGDMLEEVGRLADRREFDYLLVESSGISEPIPVAQTFAMGFEDASFDPTDTYALDTMVTVVNTHSFFESFDSGTALVEDELEDDSGRVPEEILLDQIEFCDVLVLNKCDLVPDDALDEIESILGTLQPRARIVRTEFGDVEPDGILGTGRFDFQAAQNSAGWKHELQHEHAHDPREEHGVTSFVYQRDRPFHPERVAALLSELPDELIRAKGFFWSAGREDVAMGIDKAGSSVRAGPSGQWLATLPERERRRYFAARPGLEDDWDDEWGDRMTRLVFIGREFDKKPLIDRLEDCLLTDEEMTENWDRYPDPFEPEERRELTLADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKV9</accession>
    <name>A0A3N6LKV9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfo</name>
        <name evidence="10" type="ORF">EA462_15580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87138">
        <property type="protein sequence ID" value="RQG87138"/>
        <property type="gene ID" value="EA462_15580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="9">
        <location>
            <begin position="39"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG87138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="289" mass="31190" checksum="9A2088E1F4D213D9" modified="2019-02-13" version="1">MKVGAHVSISGSRVSSDDETPPYDDVRNAIHRQLAFGGNCGQIFTTSPQVWAQPEISDEAATGFRTETAEKLEGPWVIHSAYLVNLCTPKDDLRRKSLESMQAELDAAEKLGVPYVNVHLGAHTGAGVEGGLDNAASVIDDLEVPDDVRILVESDAGSGTKLGGEFSHLAGIIDRTETDIGICIDTAHTLVAGNDLTTPDAVDETVGRFDDEIGLEYLEYIHLNDSKHDVGTHKDEHAHIGEGYIGADGMRAIVNHPGLRDLPFALETPTEDGRGFAWNIEKVLELRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLI6</accession>
    <name>A0A3N6LLI6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Gas vesicle structural protein</fullName>
            <shortName evidence="4">GVP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">gvpA</name>
        <name evidence="7" type="ORF">EA462_07505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
            <location evidence="4">Gas vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89853">
        <property type="protein sequence ID" value="RQG89853"/>
        <property type="gene ID" value="EA462_07505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033172">
        <property type="term" value="C:gas vesicle shell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00576">
        <property type="entry name" value="Gas_vesicle_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00669">
        <property type="entry name" value="GAS_VESICLE_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="95" mass="10525" checksum="1B42101D0B2D0AA6" modified="2019-02-13" version="1">MAHPQRRPDSSSLAEVLDRILDKGVVIDVWARVSVVGIELLTIEARVVVASVDTFLHYAEEIAKIEQATAEGELEDLEQLEVERRPESSPQSASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLL8</accession>
    <name>A0A3N6LLL8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAA hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88040">
        <property type="protein sequence ID" value="RQG88040"/>
        <property type="gene ID" value="EA462_14410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="242" mass="26704" checksum="C8DC80C1EC26E842" modified="2019-02-13" version="1">MKRIRFKEQTGSTRVGTYQDGMIDAAGRTYDVDDVDVLPPCSPSKIVCVGRNYAKHAEERGNDVPDRPLLFLKPPNTLAGHDDTIRVPEGKERIDHEAELCVVISEQCRNVSAENAEDVIEGYTCMNDVSNRDDQDKETNWVRGKAFDNSAPLGPVLASPDELPADAYVRTRVNGELRQDGSLEQLIFPIPELIEEITTYLTLEPGDVIATGTPDGVDRLNDGDEVEIEVEGVGTLSHRVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLL9</accession>
    <name>A0A3N6LLL9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89758">
        <property type="protein sequence ID" value="RQG89758"/>
        <property type="gene ID" value="EA462_06985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="71" mass="8829" checksum="6B9EE90A8BCBA06C" modified="2019-02-13" version="1">MEPRDVDPTDKRVLERNYDYAQKNVRLLSMWYDCEPERMVELLADRDIELSGNDWRRFGAYYRSIRRRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLU2</accession>
    <name>A0A3N6LLU2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diadenylate cyclase</fullName>
            <shortName evidence="6">DAC</shortName>
            <ecNumber evidence="6">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="6">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dacZ</name>
        <name evidence="8" type="ORF">EA462_08325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate cyclase family. DacZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90003">
        <property type="protein sequence ID" value="RQG90003"/>
        <property type="gene ID" value="EA462_08325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00840">
        <property type="entry name" value="DacZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014499">
        <property type="entry name" value="DAC_DacZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045586">
        <property type="entry name" value="DacZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19294">
        <property type="entry name" value="DUF5912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019073">
        <property type="entry name" value="UCP019073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="7">
        <location>
            <begin position="110"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="270" mass="29044" checksum="E01CA62BA5DCA888" modified="2019-02-13" version="1">MAGLDDVFGELFSSVDAIMLFGPSGSYYEQFAETEDIDAIVVGTENEVGAEVFVELPLEFDDVSERIRFGLEGALEQDIVEDGDEIVCATSVFGDEIDTISRVRANSSSRTGIYDLFSKSRAEPQVIKAVLELAIELGQKGQKGKPVGALFIVGDAGKVMNKSRPLSYNPFEKSHVHVGDPIVNVMLKEFSRLDGAFVISDAGKIVSAYRYLEPSAEGVDIPKGLGARHMAGGAITRDTNAIAIVLSESDGLVRAFKAGELILEVDPEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM13</accession>
    <name>A0A3N6LM13_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropyrimidine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89988">
        <property type="protein sequence ID" value="RQG89988"/>
        <property type="gene ID" value="EA462_08250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dus" evidence="1">
        <location>
            <begin position="108"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="251" mass="27001" checksum="A760FCDE88A96D12" modified="2019-02-13" version="1">MSSVTFSPPLALSSLSGESDADWARAGASFVGAAFLGGIALDEDSRAGARALRDRDRNEFLPSDPIAFVDRELARLDDAPLQTGFNVRTATIDPIRDVATVCRDRGAFLEINAHCRQDELCAVGCGESLLRDGDRLCTYVETAAETGVTVGVKVRADVSGVDLPTLARELERAGAGFVHVDAMDSEAVISEIVDATELFVIANNGVRDDETVREYVEYGADAVSVGRPSTDPIVLERVRTAVDRRFEHANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMA3</accession>
    <name>A0A3N6LMA3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90118">
        <property type="protein sequence ID" value="RQG90118"/>
        <property type="gene ID" value="EA462_08980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="79" mass="8651" checksum="3C678ED0B769E8C1" modified="2019-02-13" version="1">MVDADFESRVDDGDVDDHSLVVTDQDSSPIPNRRENTKTKPAINDLGVRRAVVSGTVPRNPALTSEPTRSTVSIPHLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMD3</accession>
    <name>A0A3N6LMD3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metal ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_09680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90243">
        <property type="protein sequence ID" value="RQG90243"/>
        <property type="gene ID" value="EA462_09680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="246" mass="26449" checksum="62CA41118719547B" modified="2019-02-13" version="1">MTSVVDIRNVTFAYGEKIALDDVSLSIEAGDFLGLIGPNGSGKTTLLHIMLGLLTPDSGSVDLFGRPIDEFDQGERIGYVSQQATSGGGTMPVTVRECVRMGRFAHVGHSRLSDTDRQIADEALETVGITGLADRRINQLSGGQRQRAYIARALASEADLLALDEPTVGVDAESRDAFYRLLDSLNDSGITIILIEHDIGVVTDRADQIACINTKLYHHGDTESFVESDALSEAYGATGTVVHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMJ1</accession>
    <name>A0A3N6LMJ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86755">
        <property type="protein sequence ID" value="RQG86755"/>
        <property type="gene ID" value="EA462_16605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="119" mass="13421" checksum="B36D0ED16165FDDA" modified="2019-02-13" version="1">MDPTEVLGSLGKKYSPDILRSADEPKSAQELSDELEIPVTTSYRRVETLNELGLLEDDEDVSGFGETGQSQTLYHRNVEEIVIRFEDDSIEIESKERERTDQPLSSVWEDLSRSVGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LN79</accession>
    <name>A0A3N6LN79_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87045">
        <property type="protein sequence ID" value="RQG87045"/>
        <property type="gene ID" value="EA462_15505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="67" mass="7142" checksum="E5BEB9D1EB6D96B9" modified="2019-02-13" version="1">MSYVDNTQLIGPDWKRLATRLTVGAIAGIMLVDVIAVAMVGLGAAAEEQFTDNVSVESNDDPLEFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNN7</accession>
    <name>A0A3N6LNN7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2,3-butanediol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_13010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87787">
        <property type="protein sequence ID" value="RQG87787"/>
        <property type="gene ID" value="EA462_13010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="5">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="4">
        <location>
            <begin position="182"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="356" mass="38066" checksum="269E1DA16BA15DEC" modified="2019-02-13" version="1">MKTARYHGPHDIRLEETAPPDVGPQDVRLEVDSCGICGTDLHEYRDGPIFVPDEPHPVTGVTAPIVLGHEFSGVVSETGTDVSRISRGDRVVVHPNVPCLDCHYCEEGTYRRCNASVAIGLQTETGGFAEQAVVSERQIHRLPDAVSLSAGALVEPLAVGLHAVRRSDLRTGDTAAVFGAGPVGLAVAWAAANAGAKRVFVSEPATVRRRCALEVGADTVADPVETDPVDVIRSGTIDGVDVAFEFAGREETIDDAIRSTKRGGTIVVGSVWNRQPGVDLNEVVGAERELRGTNCYGFPPRSFRTEFDAVINSLANGDVDPDTFITERIALESVVDAGFERLLEQGTDHVKILVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNX8</accession>
    <name>A0A3N6LNX8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoxR family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91103">
        <property type="protein sequence ID" value="RQG91103"/>
        <property type="gene ID" value="EA462_03645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="42"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="341" mass="37323" checksum="8F05CA886D1E888F" modified="2019-02-13" version="1">MTGTEPLALESLSEGSLRDRFDERDYVADDATVTTVYLALQLERPLLVEGPPGSGKTELGKVLAAAFDAELIRLQCYEGLTAENALYEWNYTKQLLAVQANEGTVAGTSDGESAVDATTPTDADGPSDSRTVFDEEFLLERPLLRAIRSGTDRPPVLLIDEIDRADEEFEAFLLELLSDFQVSIPELGTVSAQHPPIVVLTSNRTRGLSDALKRRCLYLHVEPPSFETEYEIVRRKVPELDAAVAAEVCAIVERFREEAFLKRPGVAETLDWAGAVARLRQDAGDGSASGDEGDPEAISPDEIERTLGCLLKEAEDVDRVDTDLLEQLRDAAATARGRLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP89</accession>
    <name>A0A3N6LP89_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1616 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91238">
        <property type="protein sequence ID" value="RQG91238"/>
        <property type="gene ID" value="EA462_04405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011674">
        <property type="entry name" value="DUF1616"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07760">
        <property type="entry name" value="DUF1616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1616" evidence="2">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="336" mass="35703" checksum="3A4FCD0799180F8A" modified="2019-02-13" version="1">MSFGTETRTRLESVRRYPSDLAAVSVLAVFSYVVIASVPDGNVVRLFLVVPFALFLPGYAVASILFPAGSRDARETASGDLERRTGGIDLLERLGLSFALSLAVVPLVVLSVAVTEWGLGTESVAAGIGLVTIALAQIGVVRRLRTPESIRFNPSSIVTAIRARRDHESRLTLSSVLLVVAIGTAVGALLFGFFAPASAGGFTELGLYSETDDGELVAGEIPNEIEPGESVPVTVSVDNQEGDDREYAIVVQQQSVEAGEVTERTAVGEIELEVPNGETETIEPEITPDAAVNETVRISVLLYEDGDVPAIPTNENADQETYVWVTVTEDPEAADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPC1</accession>
    <name>A0A3N6LPC1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91293">
        <property type="protein sequence ID" value="RQG91293"/>
        <property type="gene ID" value="EA462_04715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022454">
        <property type="entry name" value="CHP03883_F420-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03883">
        <property type="entry name" value="DUF2342_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="318" mass="35736" checksum="0083B9F8BD29A90D" modified="2019-02-13" version="1">MNLYRSARAVAGASGTDAIDWRSAAEAAKAATDAGSIALEPGEREAYARDVRDAREAVREVSGVEFDVPDTVEIQNRHHWIDANVATFERVMGSLDPQTDPFPGIARTINTGTMTVLLAFLGRNVLGQYDPLLLAETPDDDHALYFVRPNILEAADVLEVDPDRFRRWIAFHEVTHAAEFGAAPWLSTHLETRMEDGISALSEGSFDRDTFRELDAAMTVVEGYAELLMDHAFDDEYADLRRKLDARRQGRGPLQKLFRRLLGLGLKQRQYERGKNFFETVVAAQDLETASLVWAHPDNLPTNEELDRPGLWIRRVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPG1</accession>
    <name>A0A3N6LPG1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90027">
        <property type="protein sequence ID" value="RQG90027"/>
        <property type="gene ID" value="EA462_08455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="107" mass="11739" checksum="DF49CAC46C0B0B67" modified="2019-02-13" version="1">MSSLIPWSGLLWALAVLTYGFGDFLTTIRGLQRDGIEERQSGARIVLGEPPSMWRFGLFKGLLLTVFFVGYVLLEGYRFRIAIPAGIAVIGSYAVLNNGRVLLDGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPJ1</accession>
    <name>A0A3N6LPJ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminodeoxychorismate/anthranilate synthase component II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91398">
        <property type="protein sequence ID" value="RQG91398"/>
        <property type="gene ID" value="EA462_05345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="225" mass="24119" checksum="4702CB073DA662F1" modified="2019-02-13" version="1">MSPNSSSNGEPVTGAETATLRVLFVDNYDSFTYNLVEYVSQLPGTETEVRKNTASLADVRAVDPDAIVISPGPGHPKNDRDVGVTMDVLRELSPDVPTLGVCLGLEATVYAYGGSVGRAPDPIHGKASAVDHDGEGVFDGLERGFRAGRYHSLVATEVPDCLEVTATADHDGTELVMGVRHREHPIECVQFHPESVLTAVGHDVIENFLSDVRDRDRSATPPTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPP9</accession>
    <name>A0A3N6LPP9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">pdxS</name>
        <name evidence="7" type="ORF">EA462_09155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90147">
        <property type="protein sequence ID" value="RQG90147"/>
        <property type="gene ID" value="EA462_09155"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="6">
        <location>
            <begin position="16"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="302" mass="32377" checksum="12CC3BF1D45AE9CF" modified="2019-02-13" version="1">MSGETDLEELKRGTDLVKRGFARMQKGGVIMDVVNPEQARIAEDAGAVAVMSLEAVPADIRKRGGVARMADPADVTEIVDEVSIPVMGKSRIGHVKEAQILESVGVDMIDESEVLTPADDAYHIDKREFTAPFVCGARNLGEALRRIDEGAAMIRTKGEAGTGDVNQAVHHQRTIKGAIRELEGMTHEERESYARDIEAPAELVHETAEMGRLPVVNFAAGGIATPADAALMMHHECDGIFVGSGIFGAENPPEMAEAIVEATNNWDDADRLAAISSNLGEGMKGDANADLPEEERLQDRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPS9</accession>
    <name>A0A3N6LPS9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FkbM family methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91528">
        <property type="protein sequence ID" value="RQG91528"/>
        <property type="gene ID" value="EA462_06095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="120"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="299" mass="33549" checksum="1DB27B97FAA1C81F" modified="2019-02-13" version="1">MTFSPYQHLLASLYRFGHDSAIMAATISKAITKVREDGLKRFIRNTPAYTHTELSRLVKSIQYIRWQRSGSHSVSVENINAEFNINDRADFHAVTYFKENERELARDLLTEVTPGDVVWDVGANIGIYTCLLKQLPTVEPIAFEPFPENKRRLKQNLRLNGIDATIVDAALSDRNTTVEFGLASNQNGNLGGSKILRTDEGNMVTVPARTGDSLEIPQPSVVKIDVEGAEQDVINGMKKTLRTSNCRIIYCEIHHSDSGSSIFEYGSTPSHLKQTLQDFDFTVTTLEKRNNQTQIKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPX7</accession>
    <name>A0A3N6LPX7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RnhA operon protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91598">
        <property type="protein sequence ID" value="RQG91598"/>
        <property type="gene ID" value="EA462_06505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="217" mass="24078" checksum="1404EA956D8E9C43" modified="2019-02-13" version="1">MSDLEDTDGPTVDTGSDGGDSGTDDEGTAGDDELPTSVVDEAERLTRLARSATDEREREVRLERRDDLLAPHEFTARVRDDDGDAALVLHPAAWHEDGVIRTDRIDDLSRAIEISLEGAEDPDDWTAVDAHNRTLVARVRDRHGDVHGDTASALADFVGNHYAKRIESLTGPELSEFRSEYFVRNAWPSARQRDVVEKSIELVYETAGEPVPEFRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ01</accession>
    <name>A0A3N6LQ01_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91623">
        <property type="protein sequence ID" value="RQG91623"/>
        <property type="gene ID" value="EA462_06645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="128" mass="14785" checksum="C0A35CF869F10DDD" modified="2019-02-13" version="1">MDELSLGVPKPVLERLPADDDVAAPDMQEAVAGWERHLNDAIGEADDDQEAAQRALEAIDRFEERYRTYDELVPELRAWGQSPIYAIAWRTLYADVIAQLYEHDELAEHLERERNVRLVQDGIRMRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ68</accession>
    <name>A0A3N6LQ68_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription factor S</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription elongation factor IIS/RNA polymerase subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_05720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91718">
        <property type="protein sequence ID" value="RQG91718"/>
        <property type="gene ID" value="EA462_05720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006288">
        <property type="entry name" value="TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01384">
        <property type="entry name" value="TFS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG91718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="127" mass="14386" checksum="3E0C71FA03E51519" modified="2019-02-13" version="1">MGPFGTDPGRQTRRLSRSVDVARTTMEFCDECGSMMKAEDGLWECGSCGFTKPTGDAAKYTVTEDQEIGEVIESSEETSLPETDALCPECGHDRAYWYMQQIRSADESETRFFICSSCEYKWREDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS22</accession>
    <name>A0A3N6LS22_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92658">
        <property type="protein sequence ID" value="RQG92658"/>
        <property type="gene ID" value="EA462_00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="161" mass="17102" checksum="FDD7963AF9360926" modified="2019-02-13" version="1" fragment="single">DATDEQARASGRVVTMVDEATEISEETNAETETVAAAAEEQTATVSEVATGAQSLTEMADDLRNSLDAFDVTEEMHASDDTWSADREATDDLGVSESLNEFEEAEPTDSSAGDRPSESAKSADDISSEAEEDASSDERDTDGPDIVLKHDETDLETSDSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSC0</accession>
    <name>A0A3N6LSC0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-dependent dephospho-CoA kinase</fullName>
            <ecNumber evidence="3">2.7.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Dephospho-coenzyme A kinase</fullName>
            <shortName evidence="3">DPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_00820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3'-dephospho-CoA + GTP = CoA + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP-dependent DPCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92803">
        <property type="protein sequence ID" value="RQG92803"/>
        <property type="gene ID" value="EA462_00820"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00590">
        <property type="entry name" value="Dephospho_CoA_kinase_GTP_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007164">
        <property type="entry name" value="GTP-dep_dephospho-CoA_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40732">
        <property type="entry name" value="PTHR40732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04019">
        <property type="entry name" value="DUF359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006533">
        <property type="entry name" value="UCP006533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG92803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="200" mass="21932" checksum="B992CC46E8069522" modified="2019-02-13" version="1">MPRDEHGSDGSRADDTEPGDENRLLRLPDELRGELKEPMGPIETDADRLLETVDGPLIAVGDVVTYHFLQAGRPPDVALVDEQTKREAVDDEIRKTVTAETHLEAENPPATITEDVVRTLLEGLRSEGSTTILVDGEEDLVVLPAIVAAPERASVVYGQPDEGMVHVTVTDDERATVRELLERFDGDAGRFLDLLEDESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSF7</accession>
    <name>A0A3N6LSF7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92863">
        <property type="protein sequence ID" value="RQG92863"/>
        <property type="gene ID" value="EA462_01165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="437" mass="45903" checksum="522373BBCAF2C46E" modified="2019-02-13" version="1">MVEQFLRTLMRTTDVAVTGLFSPAAITAVGLADLYARLPLRIGLGLGSGVIALSSQDTGSGESGNRDEAISQAVILGALAGVPFAVFGVLFGQWAISILGAESEVVRMGGIYLAIIFVTSPARHVAIVASRSIQGAGDTRTPMYVNVVSNGLNIVGTVVLGLGLGPVPQLQIVGVGIATAVANVLSALALVFALWTSWAPAGFARPRQWTITKQLLQISAPRILEGMSTFVMEFPFNAILLVFGTEVNAAYQIGRRVYQQITAPLSRGYRTGTSIVVGQNLGDGNVDGARYDGWAAALLGLVTVGSLGGLLFLGAEPLVAFFTDDPETRRVAAEFARAYAVAAPFTVLYAVLSGALTSGSDTRTPFVGRVSGMFFGMLGVSYAFGIVLGYGIPALYASIVVYYVWATAYVARGFYRGGWIERTQTMMAERGSSPGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LTC5</accession>
    <name>A0A3N6LTC5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2085 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93318">
        <property type="protein sequence ID" value="RQG93318"/>
        <property type="gene ID" value="EA462_02970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019206">
        <property type="entry name" value="DUF2085_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09858">
        <property type="entry name" value="DUF2085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="149" mass="16144" checksum="2B1BC69C731080A0" modified="2019-02-13" version="1">MRVDTAEIRRGIAETRGFVLSHHLPEEYYRCYSPVVFGRQLHICARCVGIYPGILAGLFAYAVAPPPMTSVVLVALVPLPALVDWAVTTFTTRRGYNVVRTVTGSALGYGYGLGVGYVFVETNPFVIGVGVLYGLVAAVLLFRSNATDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUB9</accession>
    <name>A0A3N6LUB9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF655 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91154">
        <property type="protein sequence ID" value="RQG91154"/>
        <property type="gene ID" value="EA462_03935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007003">
        <property type="entry name" value="DUF655"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734">
        <property type="entry name" value="PTHR40734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04919">
        <property type="entry name" value="DUF655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="199" mass="22996" checksum="1BB1B51EBD4ADFA6" modified="2019-02-13" version="1">MSEADSDGMDVRRAVVLDYLAHGLSDDGRPQYEKSPAGYALGIDDFQLYQVAFDEDERLTIGSEVVVEPADERDIVTESHRVEYDDLSSGAQTELEYVVQDIVEEDEERFVDFYNDAQPITLRLHQLNLLPGIGKKLRNGILDERKRKPFESFEELTERVSGLHDPDDILVERILEELRDDDLKYQTFVGRREEQDRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV07</accession>
    <name>A0A3N6LV07_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4013 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91464">
        <property type="protein sequence ID" value="RQG91464"/>
        <property type="gene ID" value="EA462_05745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025098">
        <property type="entry name" value="DUF4013"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13197">
        <property type="entry name" value="DUF4013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="251" mass="25895" checksum="EE447B56108E7963" modified="2019-02-13" version="1">MDSVLSDLGSYPRRGRALERTVVGGALVFGSVLVIPALVLIGYCVRVAETTLAGSDDPPEIAPGTWRPLAVTGTAASVILLVYLVGPLALGTMLGLVVGALGYYGLLGLAPVVADHDTLVWGTSVVAALVAALLALAFVAFTLVVYYHLPAALARYAETGSLRAAFERKPLVRIATTSEYALGMAALQLVPLVVPIVAVLCLVSIVGIVVLPAVPFVAALVSSRLIAVAVARSRSADEPSNVSVTRSRGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LW79</accession>
    <name>A0A3N6LW79_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93077">
        <property type="protein sequence ID" value="RQG93077"/>
        <property type="gene ID" value="EA462_02405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="75" mass="8704" checksum="A87ABAAEDD201D85" modified="2019-02-13" version="1">MTLFTFFLGLLVRQDLAEALIYMVENYALMLLPLRWPVNEIIAADTVSEFIFSHLLTISLGLFVATIKYRMSVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWE9</accession>
    <name>A0A3N6LWE9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93167">
        <property type="protein sequence ID" value="RQG93167"/>
        <property type="gene ID" value="EA462_02895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="162" mass="16223" checksum="8243399635FE8AD4" modified="2019-02-13" version="1">MQQTGHYGAALVAYAPVGFVVAVLLSAELAAVSGFVAIGLSVLPDVDMKTARIAHRGVTHTVHFAVLVGVILGLTGILVGVQTNFGAPFVLGSLGLVIGTIAVASHIAVDALTPMGVDPLFTGNRYSLSVTTAADPVANYALFCLGVTAIVLAAGLASVVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWK5</accession>
    <name>A0A3N6LWK5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_03315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93237">
        <property type="protein sequence ID" value="RQG93237"/>
        <property type="gene ID" value="EA462_03315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="792" mass="87384" checksum="5238A3A525D1FEE8" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LX69</accession>
    <name>A0A3N6LX69_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86207">
        <property type="protein sequence ID" value="RQG86207"/>
        <property type="gene ID" value="EA462_17210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="95" mass="10740" checksum="DD46395FE58C1846" modified="2019-02-13" version="1">MAWECEIDGCGSVFDDVEAAIIHQATEHERPECKVCGTIVPDGYLAIRHAFNEHSRAEYVRAYGASSEEVREREELLEEIESVADMELIANQLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXH9</accession>
    <name>A0A3N6LXH9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Globin-coupled sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86771">
        <property type="protein sequence ID" value="RQG86771"/>
        <property type="gene ID" value="EA462_16690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01068">
        <property type="entry name" value="globin_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039379">
        <property type="entry name" value="Protoglobin_sensor_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="265"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="406"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="507"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="542" mass="59890" checksum="905FEB4E37CDAD4E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY23</accession>
    <name>A0A3N6LY23_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="11">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thrS</name>
        <name evidence="14" type="ORF">EA462_00430</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="11"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92734">
        <property type="protein sequence ID" value="RQG92734"/>
        <property type="gene ID" value="EA462_00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015011">
        <property type="entry name" value="Threonyl-tRNA_syn_edit_dom_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08915">
        <property type="entry name" value="tRNA-Thr_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="13">
        <location>
            <begin position="209"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="11">
        <location>
            <begin position="210"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RQG92734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="620" mass="70294" checksum="0468E5077D5CC567" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY34</accession>
    <name>A0A3N6LY34_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional oligoribonuclease/PAP phosphatase NrnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_15260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87001">
        <property type="protein sequence ID" value="RQG87001"/>
        <property type="gene ID" value="EA462_15260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="156"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="3">
        <location>
            <begin position="352"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="500" mass="54049" checksum="9537B2CB4892F665" modified="2019-02-13" version="1">MVFRLVLGCGTVGRHVVERLSERDNDGRLLVIADDEAAVEALRDESVPARQGDPTDASVIRNVDAPDVLFVGADRSDVNRAILETARAQFPRASIVAYRGGNPSENDRSLFDELADHVIDAADSIVDGVLDQTASPSAETAIELRQHLESIDGRLAVVTHDNPDPDAIASAVALVDIAAAVGLEADACYFGDISHQENRAMVNLLDLDLRNLSPDEPLTDYDAFALVDHSRPGVNDQLPEELYVDIVIDHHPPRGPVSASFVDLREHAGATSTVLTEYIDRFSLTFHPATATALLYGIRIDTNDFMREVAPADFRAASILWPHVDTSLLERIEQPTVDGETLGTIARAIQNRIRRDSIAVASVGRLTDRDALPQAADQLLAMEGVETTLVFGFEDEMAFLSARSRANDIDLGATLRDAFDRIGSAGGHADMAGAQLEIGILGDVDDSDEVDSIVSVVEEVITNRFFEAIDTRPGSSVGTYTRTSEWLFTQHGETDGGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY98</accession>
    <name>A0A3N6LY98_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87091">
        <property type="protein sequence ID" value="RQG87091"/>
        <property type="gene ID" value="EA462_15790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="119" mass="12985" checksum="1E605E62B54853D8" modified="2019-02-13" version="1">MNRQTTSEIRFSAPKSRQIRLAFLVVWFTDMVATMFLFAVPYATELNPITNLFFGSFGFLGVILAALCYAAIIVLMGGYLPDPIDIRFVAALAVIYGVFVINNVLLLVSGTSLISIVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYB1</accession>
    <name>A0A3N6LYB1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92844">
        <property type="protein sequence ID" value="RQG92844"/>
        <property type="gene ID" value="EA462_01055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="103"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="218" mass="24682" checksum="1DC8BE2A3BAFA412" modified="2019-02-13" version="1">MAVEVRLPLPDEQVFRYAAMDEALEILARNPTEEFSNRDLQQLTGYGGPSVSKALALLEAMGLIVRRDVGNRTLYRIDERRLLDSDDPLLEIPQAEFREPLGRFVERVDDEVPSIAGILCFGSVARGEADRASDVDVFVLVDEDEDPVSARRTVSDVVRDLEDEPIDGDRYEFEVFVESPESARKRGEDLRPILQEGIPLVESETFRRVKRDVFEVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYV5</accession>
    <name>A0A3N6LYV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87873">
        <property type="protein sequence ID" value="RQG87873"/>
        <property type="gene ID" value="EA462_13500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="13046" checksum="02054AE7F0D5A2BB" modified="2019-02-13" version="1">MNEGIVRIATEHLDRFAGVATEPMNDPDAMIEELERAVTDLDVRFGPSPRVLRPGQAIFGTDAPFDVGGGAVSIERSLRESGNWTSLTPTDAEFTARRYSVYSRSVAVSNGARCDQGDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZC4</accession>
    <name>A0A3N6LZC4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87122">
        <property type="protein sequence ID" value="RQG87122"/>
        <property type="gene ID" value="EA462_15045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="376" mass="39265" checksum="00BD46A60F521ECE" modified="2019-02-13" version="1">MLLVVALAWAAIQTGRFVLPPLLPEMRADLSLTLTQAGIVLTVFNAMYAVSQYPSGRLSDILTRATLIVPSLIVLVLGSLLIGSSTNYPLILIGAGVFGVGMGMYAIPSRALVSDLFVEHRGRALGILGAGADVGGGLAAGLAAVVLAIATWRTPFFPLAVALGGLAVLFVVWNTEPYAVERTRLGALETMRRLIATPGQRWALLAFILFYFMINGVLSFLPAYLREVKGFSPLLATVSYALLFALGIVVKPIAGGVSDRFPRRQVATAGMLVGAIALGVLLIAGSLVGVLIGIVLFAVGYKTQFPVVDALLMDAAPDGNMGGDLGAARTVFLGVGSLGPAFVGVTADRYNYTVAFAGLAVCLIVAAAILFWQGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M042</accession>
    <name>A0A3N6M042_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87884">
        <property type="protein sequence ID" value="RQG87884"/>
        <property type="gene ID" value="EA462_13555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="365" mass="39703" checksum="C7E36A054551FEB9" modified="2019-02-13" version="1">MLSIIPAENQTMTFRESNSQGSGTRRSFLRNAGAVGALGSLGALSGCLGDEEEGGADNQYTFGAGPSDSMSFAMANQFAHNLESNSDHTVDLTSQPSSQALSLVLGGENEMAWATSFIGQQAADAEGPFADVEMNYTPMQIMSYYYMRIGLVAPVDSDLEYYSDLANEDFAPGPAGASFYPPFEMALQETLSEDDISPRHMDVSELADGLAEERAVAAGGPLKMNAIIPAFMEQTYSQNDCRLLAWDDDAIDGIQSNPMLSGVYESNDEMGDIQEFTSSDETFVVSADFIVFGSEQVSADVVYEMLDTLWNARDELEEGHAAFAPFHDDEFWVENLTTELPVHPGAADFFEEHGIWNDDFEVGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0E4</accession>
    <name>A0A3N6M0E4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88014">
        <property type="protein sequence ID" value="RQG88014"/>
        <property type="gene ID" value="EA462_14245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="152" mass="17164" checksum="BF9D459F781F822F" modified="2019-02-13" version="1">MTGHDSPYTNFTYEVRIDDDMVGGFTRISGLGAESNVLEYREGGLHEVTHTFPSDVAYSNVTLHRGVTDDDGFLDWIMESLSGARADVRSKVSVAMKDREDRTRWTWVLINAYPVRWDGPELVANARSDREETGLSIERLELAYESLDARTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1B2</accession>
    <name>A0A3N6M1B2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF357 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88871">
        <property type="protein sequence ID" value="RQG88871"/>
        <property type="gene ID" value="EA462_10760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036809">
        <property type="entry name" value="AF1782-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023140">
        <property type="entry name" value="DUF357"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04010">
        <property type="entry name" value="DUF357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158372">
        <property type="entry name" value="SSF158372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF357" evidence="1">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="95" mass="10210" checksum="09B31DF6791EF856" modified="2019-02-13" version="1">MSADLEEKTDRYGELLAEALEEATVAPPEGTPMADAADDCYEMAASYLADGEHFRENDDPVNALASFSYGHAWLDAGARVGLFDVPTEGHLFAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1H5</accession>
    <name>A0A3N6M1H5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YkgJ family cysteine cluster protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88941">
        <property type="protein sequence ID" value="RQG88941"/>
        <property type="gene ID" value="EA462_11150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="246" mass="26417" checksum="3EA77D5DE82D4DE0" modified="2019-02-13" version="1">MQSLETELAEARSLAVTELADAIESIGFECTRCGACCTADDDEDHTATVFPDEARDLQSASQKQPTIDAEGEARSGGTKTPAETPESTTREWRDVARPMPYGLDERDGALEGETFEWALQTDSCGDCAFYSENEEGVGSCVVHQDRPLICRTYPFSVALAGTSQPMGEAVDENGIVRAHECEGLGRDISREDAESLANALKARAVRELEEAIAVRDAFEPANPGPGEVVVHDSEGAKRADGTSLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1Z1</accession>
    <name>A0A3N6M1Z1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89810">
        <property type="protein sequence ID" value="RQG89810"/>
        <property type="gene ID" value="EA462_07260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="300" mass="32655" checksum="9581E8B257C840F2" modified="2019-02-13" version="1">MPAESLESGYLFDLYRRYIGEPEDRTDVYLGFGLFLGGIGLAIVALVLFLWSSTLDAQSPAYSWAEPAYALVMISLPVTMLGIVVLLPAERRVLYTSVVGVGVTLAATAGFVYAYPEDWYFHGADYTVEVIATYAVGLAAISASTGAALIAHYLDMARAAERVDHEDSPGESEAKSYSDEEIQADIDEAMEDVELSWGGVEKNEQTRLSFSEDTFDDVDVDGQAKTTRSSGVDAQVAGLKGLKGGETTTTTSSSTVDDQTEKLRQLREQQRTEDAVDGDTDRWASVRTLLDRIRSVLGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3I1</accession>
    <name>A0A3N6M3I1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89761">
        <property type="protein sequence ID" value="RQG89761"/>
        <property type="gene ID" value="EA462_07005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="102" mass="11304" checksum="CF5A3F2F21A6FD3D" modified="2019-02-13" version="1">MRLVEQARSIFAELGYTIEGTGPAFRAERAWKVVHVNTVLETDSLPTSSAGQFHCFVAEPDDADRLEDRLNNVDPAYEWAIIVVDGDEYQVERAPPGPRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3Y4</accession>
    <name>A0A3N6M3Y4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-hairpin-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89931">
        <property type="protein sequence ID" value="RQG89931"/>
        <property type="gene ID" value="EA462_07940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="290" mass="31955" checksum="5543BED3EB4EE72B" modified="2019-02-13" version="1">MGRADLCDPAPHRSRTDDADPVDFSSEHTTGYDGGVRIYLGPVHARGTESTNRRWLEMSERRLDRVGDASTLVPTAHRTRGLFHVTVVRGKPSRPVGVRYGRSVNRVSNEHVAGESAAIDVEIDSDERDALEAANVDAVDVTARDCSYRVLLDAGVDEEIADALRRRFSLPWSFETDGDLDRRSTEVKGLGDGERAWIAASEDDGWQAFERAHSRATRGESDDVARPWPRPTPVEAVAGIGPEDADALAEAGIVSAERLATIDATQIADVLEFDVLHVRTWRYNARELIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M439</accession>
    <name>A0A3N6M439_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89991">
        <property type="protein sequence ID" value="RQG89991"/>
        <property type="gene ID" value="EA462_08265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="182" mass="19093" checksum="805644928132F92A" modified="2019-02-13" version="1">MDAIRSPPIETLAIACKRYGPGRMPGAGRRDIGAGYAGSAAALAIAIGFALSMAVLPTLGLSSDFAHPFWGLAALVSLPIVVPVAFVASVFVWRALPSDVPYFGVVAGFLATVVTYLASLAIVFLIRLLWFWWTGAESVLVDVGGFVALIGLFATVLTVWLTIPVGCVSGAIYEYARRISSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M543</accession>
    <name>A0A3N6M543_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90381">
        <property type="protein sequence ID" value="RQG90381"/>
        <property type="gene ID" value="EA462_09480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="137" mass="15539" checksum="8AF823DC1639EEF0" modified="2019-02-13" version="1">MSDPFTVDVPVRYRDLDTLNHVNHAVYATYLETARIDYFESLLEEKPQDLSYVVANLEISYERPITRSDEPTVATWVSELGETSCTMRYEIRTDDDVAATAETTMVYVDPETVQPAPVPDDVRTRIETSENLDAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5H9</accession>
    <name>A0A3N6M5H9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HPP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91280">
        <property type="protein sequence ID" value="RQG91280"/>
        <property type="gene ID" value="EA462_04645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="174" mass="18168" checksum="BFB5B2CD424AABC0" modified="2019-02-13" version="1">MGLRDDVSAGINVILHFLFLGGIAWATGQPFLFPSLGPSAYLMATGEQPRAEGAYHVIGGHAIATACGLAAYLLIADGLLVVDAFDQGEPFSPEVARLVISAIVAMVLTTVGMLWTDTNHAAACATTLIVALGLMSTLAEGIVIVAAVVLLVGFHDVIVERIQTHYGLEPEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5L7</accession>
    <name>A0A3N6M5L7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88039">
        <property type="protein sequence ID" value="RQG88039"/>
        <property type="gene ID" value="EA462_14405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="479" mass="53378" checksum="03DD60FEA14E641C" modified="2019-02-13" version="1">MLQVDMRDDASPHRVDSVKRRKVLKTVGGTSVALSIAGCAGDEEPDVGNGNGNGVDDVDADTGDIDPDEWADLEGQEVHILTQESSEDYQRYWQELAERFNAATGAYVRMEYTGFGMGLNERIAELVQAEDPPELSHLGHPDAATYGDLGQLADHSEVVDHWEDRWGDIPDGARFTVDGNDVFLPMLTNPYTNWYRDDVFDEVPDTWDSQLAMAEEHDEGQGGTRGAAFTMVTGDTNTTQTGFISYAWSAGAQFFGRDGSDAIDPVFDSEYLDETAETLEFMDQLYEFSDDNLDMTGGDINQAIGNELSYQVGWVGSRPKFYGEGTDFSGEIRPCVWPGKDGNHTPWGHVQGYASFEGADNEAAMEFLRFWAEPENFIGFYFADPIHNAPVIEEIRDSEEYQAELDALPDNWNVPEDLPFDHIDITNELPAETEPPNEHTGTIYDSQILLEMVRDVLVDNEDPETAASQRADEIRDLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5N7</accession>
    <name>A0A3N6M5N7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88069">
        <property type="protein sequence ID" value="RQG88069"/>
        <property type="gene ID" value="EA462_14565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="412" mass="45619" checksum="934A6ED99D150B23" modified="2019-02-13" version="1">MYDKLTQSHMPSDTRQNNGVDQSQNGIDVGSRRAFLGLGSAAALGSLAGCLGDDDNGNGNGNGNGGATDDSGAGDDEPEKPDQITVRAWGGVWEGSLEESIAEPFTEETGIDVQFDNTDRTVMQGDIRTAIQQDREPPVNVMWTVEPAAHEEYRMDLAEPLDESIVTNIDEMFNHAIPDVDDSIPYLTLYSYTYALSYNEDALEDITGSSEPPESWNDIKSDEFENAFGQYDNAYGFWPVFSELSDTPLDSDDLSAVYDEIEEFEPTIGHIGDDTSLTEQIREGEIACAPLIMNNLLDAYEDGEPVGWTLPEEGATLRGDSMYTPQNQSESELYWSQVFINFAAAAEHQSEWTESLGLPMTNSNTEPMDYMIDDPSYPTDEEDFETLLTVDLDVYAEESPEWFEEFNIIMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5Q0</accession>
    <name>A0A3N6M5Q0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl24</name>
        <name evidence="5" type="ORF">EA462_05080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Located at the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="2">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91350">
        <property type="protein sequence ID" value="RQG91350"/>
        <property type="gene ID" value="EA462_05080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_L24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_L26/L24P_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="PTHR11143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="122" mass="13741" checksum="CF2F324B01E33125" modified="2019-02-13" version="1">MSKQPHKQRNRTERAPLHKRGTQLHATLSDDLRDEYDTRRTRVNAGDTVEVMRGDHAGEEGEVLRAVLEDGVVHVEDVTVETADGEEVPRPLDTSNVRITELDLSDERREARLEGDADGDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6A3</accession>
    <name>A0A3N6M6A3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_10455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88816">
        <property type="protein sequence ID" value="RQG88816"/>
        <property type="gene ID" value="EA462_10455"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="218" mass="23323" checksum="9B3DFC166BB2FC01" modified="2019-02-13" version="1">MIPLLHDFTDATVLVFGGGPVGARKARRFAREATVIVVSPTFTDRDFGPSERVRAAPGPTEVAAWIDRTSPALVVAATDDRDVNDAVDEAARARDVLVNRADRSGGRDFGSVVVPATVRDDPVVVSVATGGRAPALSRYLRRELEESISGAGSMATFCAELRRELKSRNVSSSRRQEIVTDAVNSPAVWTALRSGTSNDRQVIEDVLDEELSTGGEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6Q1</accession>
    <name>A0A3N6M6Q1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89006">
        <property type="protein sequence ID" value="RQG89006"/>
        <property type="gene ID" value="EA462_11515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046260">
        <property type="entry name" value="DUF6293"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19810">
        <property type="entry name" value="DUF6293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF6293" evidence="1">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="303" mass="34538" checksum="C0FE5A01F9F7236B" modified="2019-02-13" version="1">MQTHIVPVGFDYDRLIAPLVRDQIDVDSVILLEGAVGSEANVEYSRHLSKKLETDFRNLLGAETDRFVLEDVYDYDGAFEQAFDLITVELDRGNEVWVNVAAMPRTVSFAFANAAHSLMVEREDEREQIHTYYTAPEKYLETELAEELREQITLLENLDDDDRIGATAHDRIESRLESARDLLSEFDERGTTIGAKKIGDSHIVELPVASFSNVKPFEELILYKLGEDGEFASVSELAESLARELNEEYTDSFRSKVIYNVDRLGPGGKGYIEREERGKSYRTRLSRIGELWVRAHSDNDTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6R9</accession>
    <name>A0A3N6M6R9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biotin-dependent carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_11630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89026">
        <property type="protein sequence ID" value="RQG89026"/>
        <property type="gene ID" value="EA462_11630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="323" mass="34267" checksum="35789C38543342B1" modified="2019-02-13" version="1">MIDVHEGGISSTVQDLGRTGHYHIGMPPSGAMDEYAHTVANYLVGNDADAATIEMTYQGITATFDDDAVIAITGADMSPELNGDPIGSWETVAVEAGDELSVQFATDGARAYLAVAGGIDVPEVMGSRSTYTLVGIGGHEGRGLEAGDELSVGEPPNGSVDLVGTRLPDEYIPEYADENAVRIVVGLTSYRLTDEARATLCDAEWTVSAEADRVGYRLEGPDLEFEEREQPFGAGTDPSNVVDLGYPIGSIQVPQQPIVLMQDAVTGGGYATVGTVISADRGLLAQRQTHKTVSFESVDVEEAIDARTRRSERLKEIRSVIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6Y6</accession>
    <name>A0A3N6M6Y6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease PrsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89096">
        <property type="protein sequence ID" value="RQG89096"/>
        <property type="gene ID" value="EA462_12040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="335" mass="36446" checksum="3B683E453AF1F26A" modified="2019-02-13" version="1">MQRRRDPVERADQQSTDLYDVSTWEPRSFLDVLAYSIYNAINYGLRAIVLAVALAITLLLLVQPGILVLEQPLLGLFFGLSVVPAALLAGFIWYTDITSNEPIGLLVATFVLAVLFATFAAVVNSVTRPWFEAIPLVGTVLFFFLIVGPVEETVKLLAVRVFAYRSESFDAVIDGAVYGAIAGLGFAAIENAIYIAETVSETEMGLYTAATGITTVRALVGPGHVIYSAIAGYYLGLAKFNPQYAGPLVVKGLLIAAVVHATYNSTVSVVPDVIASLAAIPLEFAFIGYVILFDLAIGYYLYRKIVRYRRTYSSVRNDTDDASSPELTEFEPPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7C8</accession>
    <name>A0A3N6M7C8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobaltochelatase subunit CobN</fullName>
            <ecNumber evidence="2">6.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cobN</name>
        <name evidence="2" type="ORF">EA462_12900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89256">
        <property type="protein sequence ID" value="RQG89256"/>
        <property type="gene ID" value="EA462_12900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011953">
        <property type="entry name" value="Cobalto_CobN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02257">
        <property type="entry name" value="cobalto_cobN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1296" mass="143005" checksum="7DCF0792E09564D5" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7E0</accession>
    <name>A0A3N6M7E0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89276">
        <property type="protein sequence ID" value="RQG89276"/>
        <property type="gene ID" value="EA462_11450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="86" mass="9187" checksum="AE8A082F84B937B5" modified="2019-02-13" version="1">MAIVDLVARMDDVDPLDLDPLYHAIDPDALDSICESSSGPTAFEFLYAGWTITVESTGVAGETEISLIDAPRHADAVEMVDTESST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7E8</accession>
    <name>A0A3N6M7E8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M20 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89286">
        <property type="protein sequence ID" value="RQG89286"/>
        <property type="gene ID" value="EA462_11975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="173"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="368" mass="38709" checksum="ED197C03D68BEB7D" modified="2019-02-13" version="1">MESQIVDLTRALVGIPSHDDETDAGTHVEDWLRRETDAAVTRDDAGNVIARRGAHGNAETLALVGHHDVVEPAPTQLVDGADPKRGAAYAIEERDGRLYGRGTADMKGALAAAMLAFREADPAGELVFASFVGEEVGGIGARHALENGFGPDVAVVGEGSTGYSSPAVTDVAVAHKGRRGSTIVARGSAAHASEVDAGENAIYRATDAISLIRDLEVPSVDVAGETIDGSLVVTEIDGGTAMNVVPDRCEMTVDERTVPGTRAPIERVESVEGLEWIVDQDLPPMRCDDDAFAATVLEAADGTQSGTPELVTKPHATDAGWLSQSGTECVICGPAEPGQAHTPDESVSIEVLERCSETYRRVAERWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8G7</accession>
    <name>A0A3N6M8G7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytoene desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">crtI</name>
        <name evidence="5" type="ORF">EA462_06860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91661">
        <property type="protein sequence ID" value="RQG91661"/>
        <property type="gene ID" value="EA462_06860"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="520" mass="58080" checksum="52F5DB9F57967ED7" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8H6</accession>
    <name>A0A3N6M8H6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="10" type="ORF">EA462_06920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the protein translocation apparatus. Forms a complex with SecF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91671">
        <property type="protein sequence ID" value="RQG91671"/>
        <property type="gene ID" value="EA462_06920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_A">
        <property type="entry name" value="SecD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024912">
        <property type="entry name" value="SecD_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG91671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="546" mass="59641" checksum="268271671541DBB5" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M984</accession>
    <name>A0A3N6M984_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90066">
        <property type="protein sequence ID" value="RQG90066"/>
        <property type="gene ID" value="EA462_08685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="65" mass="7008" checksum="33DD58B011900D30" modified="2019-02-13" version="1">MTAFPVLVGNIWYPFRPVLANDEKASDATVTRASTTFEDGIWARRRSSKMGVDDGVSAVSSSGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9X9</accession>
    <name>A0A3N6M9X9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90366">
        <property type="protein sequence ID" value="RQG90366"/>
        <property type="gene ID" value="EA462_08640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="281"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="574" mass="64379" checksum="DEAE3C5A502A2274" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MA92</accession>
    <name>A0A3N6MA92_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper-bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93240">
        <property type="protein sequence ID" value="RQG93240"/>
        <property type="gene ID" value="EA462_03335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper-bind" evidence="2">
        <location>
            <begin position="132"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="203" mass="21651" checksum="A473096A1289D9F4" modified="2019-02-13" version="1">MPSDEPRSRRKVLQLGSAVAATAFIAGCGGPGDENGEEPGNGNGVEPENGAEPGNGNGENGDPEANGEPENGEENGNGNDDNGENDENGENGDAIDPDDEIMLGGETQAWMGQEPESIADEENPTLTLEEGESYEITWENLDGVGHNIEIRDDDDEVVDDYETEIIDEEGETQTLEVDEVTDEMAAYVCEPHEGTMHGDIEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBA2</accession>
    <name>A0A3N6MBA2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92741">
        <property type="protein sequence ID" value="RQG92741"/>
        <property type="gene ID" value="EA462_00470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="487" mass="51060" checksum="1DF4B913AEBFE0F6" modified="2019-02-13" version="1">MSSAGEPDEGNLTEGSLVRPMFMLAWPLVVIQLLQVAYNVGDTFWLGALSPDAVGAVSLAFPLLFLLIAIGGGFTTAGAILIAQHTGAESGKDGLIAGQTLSYISLIAVVLGIVGYFATDPMLALLPADPETEAAIVPLAAEYLRIFFLGLPFVFGFYVFVALMRGYGSTRAPMRVMLVSVIINLVIDPLLIFGVGPLPRLEIAGAAVATVLSRGVATALGFYILYYTDVGPDVQASHLRPRLEYVTEITRLGVPTALEQSMTALAMVTMTAIVVTFPPAVVAAYGLGNRLISLAFLPAMGMGQAMDSIVGQNLGADRPERASSATWLGAAVVGSIMAIAGLIAFLFPEPFVSVFLTAEAEGRAATIDYGVTYLQFAAFAFVFMGVMQVFLGAFRGAGNTKTALVFAVLGLWIVRIPASYYLIFVAGWGTTGIWMGVVLGDVVGAIAAVAWFSRGTWKESIVDNSTDESGTETDGTSAAAEGESVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBJ0</accession>
    <name>A0A3N6MBJ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92831">
        <property type="protein sequence ID" value="RQG92831"/>
        <property type="gene ID" value="EA462_00975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="177" mass="19875" checksum="F0D5E9D88BF79DE8" modified="2019-02-13" version="1">MTERNPTFVRRKFTITKVLDQMLQEMATRHYQGNVSLCLRAAIESHRENLEGEGEFAAHQIKRQLDGLEQRVQKIQMNVDELPIETAKNEKKGIAQSVQWGIKMADGMPAIVEVLDNASSPLRLEDLLEQTELSPPRLQADLSQLVDHGLVVETTDEQQRFGLAGWVNSPGDGETGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBZ4</accession>
    <name>A0A3N6MBZ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_01965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93001">
        <property type="protein sequence ID" value="RQG93001"/>
        <property type="gene ID" value="EA462_01965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="343" mass="36868" checksum="FBFA7AA23D7D38D7" modified="2019-02-13" version="1">MTEVTLDNITKRFGSETAIEDVSLTVRDGEVLSIVGPSGCGKSTTLRTVAGFETPTEGRIMFDETDVTDVRAENRNVGLVFQDYALFMNMSVMENATFGPRMKGVPKEEREAKAMELLELVGIEELADRDPASLSGGQQQRVALVRALAVEPEILLLDEPMTGLDAKLKKRLRREIGQLLTDIGVTTLYVTHDQTQAMAMADRVAVLNDGRIEQIGTPETVYEQPANPFVANFIGTSNLLPATANGEAVDLGFATVEVDELPTTDGDVTVVTRPDDFTLNGGPIQADVLDTFYIGGTVQMIVELPDGNQISLNVNPKQSDVTGVGPGDQVGLSLDASNVHVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCA7</accession>
    <name>A0A3N6MCA7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="4" type="synonym">rpl29</name>
        <name evidence="5" type="ORF">EA462_05060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91346">
        <property type="protein sequence ID" value="RQG91346"/>
        <property type="gene ID" value="EA462_05060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="68" mass="7547" checksum="404967555B876079" modified="2019-02-13" version="1">MAIIHVEEIRDMTAAEREEELEELETELLNAKSVLAAGGAPENPGRIGELGRTIARIKTIQREEGDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCF3</accession>
    <name>A0A3N6MCF3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl11</name>
        <name evidence="9" type="ORF">EA462_05390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91406">
        <property type="protein sequence ID" value="RQG91406"/>
        <property type="gene ID" value="EA462_05390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="7">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="157" mass="16377" checksum="9864FF330A9E4EBE" modified="2019-02-13" version="1">MAGTIEVLVPGGQANPGPPLGPELGPTPVDVQAVVQQINDQTAAFDGTEVPVTVEYDDDGSFDIDVGVPPTAALVKDEADFETGSGEPQKDFVADLSVDQVKTIAEQKHPDLLAYDTKNAAKEVVGTCASMGVTIEGDDAREFKAKVDAGEYDETLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCU4</accession>
    <name>A0A3N6MCU4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93331">
        <property type="protein sequence ID" value="RQG93331"/>
        <property type="gene ID" value="EA462_03425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="296" mass="33038" checksum="BF6978A1B140E9EC" modified="2019-02-13" version="1">MLGGAVLWHRVRGRIADLTGDGNDVITERHAGAFVVRRRLDPDRIEAVLERVDRRCADGDPDWLLGVDGASTASLFLDRSSDEPELRWYVEVPRNELERRDDPATTIAERFPVSHDAVVPGDDSVDGELLVHAVHPRRPRTLEAAEAGLLGRDELASDRTVDVELVRMDLESGLPERLADWLAGVSRRVIDGELSLGPIETWSEEMLEAEAMYTESVVLERRAGGYSLVQYMETAEMAAVYEAYYDTWNPVARAAELVLGRVLENPDDVLTYPIESGTEPLAHAIDPDRFRHPSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFJ5</accession>
    <name>A0A3N6MFJ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR00341 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92676">
        <property type="protein sequence ID" value="RQG92676"/>
        <property type="gene ID" value="EA462_00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="PTHR20992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="430" mass="45818" checksum="DAC2180ABB26F3E7" modified="2019-02-13" version="1">MRLVQLTVPTGKRETILEALDERGVDYVVTDENSNREYTAVVYFPLPSQAVEGVLDELQDAGIDEDAYTVVVDAETVVSRRFEALREEYDNGDVESDRISRQELQAEAESLTPTFAVYSIMTIISAVVATAGLLLDSPAVVVGSMVIAPLIGPALGAGVGTVINDEDLFVESVLYQILGVVLAIAAAAVFAWMVRITNVVPPGLAIGEVDEISERLAPDLLSLAVALGAGVAGIISIATGTSVALVGVMIAAALIPPAAAAGIAIAWGQPSAAIGSTALVLVNVLSVNLAGLLTLWYAGYRPENLFTHGETEERVRRRVVGLVVIVLVFAVFLGAITYSSFVTSTFEENARGEVELVLDEEEFAQYQLLEFEVVMDQDYPFIGPERVVVTIGGPPGESPPELADTLHERINQHADDPVGVEIRYVGLVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MH30</accession>
    <name>A0A3N6MH30_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93306">
        <property type="protein sequence ID" value="RQG93306"/>
        <property type="gene ID" value="EA462_02285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="62" mass="6306" checksum="87485E2D425E4BE9" modified="2019-02-13" version="1">MTDRVSSDTTSGTGDADPPGPTRCPRCNTPIAMVSSTGPLTHIATPCGCQVSADVLDKGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MQV0</accession>
    <name>A0A3N6MQV0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylaspartate ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EA462_17170</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12829"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:36986"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="4.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methylaspartate ammonia-lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.2" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86199">
        <property type="protein sequence ID" value="RQG86199"/>
        <property type="gene ID" value="EA462_17170"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050096">
        <property type="term" value="F:methylaspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03314">
        <property type="entry name" value="MAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006395">
        <property type="entry name" value="Me_Asp_am_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022662">
        <property type="entry name" value="MeAsp_NH4-lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022665">
        <property type="entry name" value="MeAsp_NH4-lyase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07476">
        <property type="entry name" value="MAAL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05034">
        <property type="entry name" value="MAAL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017107">
        <property type="entry name" value="MAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00007">
        <property type="entry name" value="methylaspartate_ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01502">
        <property type="entry name" value="B_methylAsp_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAAL_N" evidence="14">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="MAAL_C" evidence="15">
        <location>
            <begin position="164"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>(2S,3S)-3-methyl-L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>(2S,3S)-3-methyl-L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RQG86199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="429" mass="46000" checksum="610A318E7F989898" modified="2019-02-13" version="1">MRITDVHATPGYAGFFFDDQRAIKRGAQQQGFTYDGDPVTEGFEAIRQAGEALIVDVTLEDGTVHRGDCAAVQYSGAGGRDPLFRARASVPVVDGPIAEALVGRDARDFLANAELLEDLRPDGTALHTALRYGVSQALLAAAAAARTTTMTDVLADALGTVPATDPVPVFGQSGDDRYENAEKMIVKGVPVLPHGLINSREKLGRDGDRLLEYVAWLVERSAELGPAEYEPTFHVDVYGTIGAWFGPPYDRPEVVDYFATLAEAAAPHPIRIEGPIDADGRSAQIDAMAALRDGLRDGGVDVELVADEWCNTLADVRAFVDGGAADLVQVKTPDLGGVHRSGRAVRYCDGTDTRAYLGGTCNETATSARTCAHVALATDAAQVLAKPGMGFDEGYMIVENEMRRTIARRTRRRESIRGTNCETEVTTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MR13</accession>
    <name>A0A3N6MR13_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_16150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86673">
        <property type="protein sequence ID" value="RQG86673"/>
        <property type="gene ID" value="EA462_16150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="171"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="242"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="526"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="665" mass="74531" checksum="E745594F1BD04B5B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTH1</accession>
    <name>A0A3N6MTH1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88105">
        <property type="protein sequence ID" value="RQG88105"/>
        <property type="gene ID" value="EA462_14345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="153" mass="15976" checksum="659F57E256E6779B" modified="2019-02-13" version="1">MPSVSPADPVRSILVATDGSDVASRAIERALTVAERTGASVHVLTVVDTDGAPLRFDIESVHDLEDARERLVEDVVSAFDEHTVDVTGAVLRGTPARAIVTYAEENDVDLIVIGRTGYGGVTETLLGGTADRVVRTASVPVVVVPDLGGGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTW3</accession>
    <name>A0A3N6MTW3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88822">
        <property type="protein sequence ID" value="RQG88822"/>
        <property type="gene ID" value="EA462_10490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="13236" checksum="BC565DB1D5AE224C" modified="2019-02-13" version="1">MLGVASLILGAIVTVVFASWLVRRFRGGSRSTDQAESWQRHREAQQRAPPVDVGDVRTAAIHEFTEHHSGERQAVCKIEGFVVFVEDVPTDLESADVVEFKLLSFNRGHTSATATFLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWB0</accession>
    <name>A0A3N6MWB0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89762">
        <property type="protein sequence ID" value="RQG89762"/>
        <property type="gene ID" value="EA462_07010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043854">
        <property type="entry name" value="DUF5816"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19133">
        <property type="entry name" value="DUF5816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="79" mass="8763" checksum="0C1F37385F8539C7" modified="2019-02-13" version="1">MQPISIDGTGTIYVSEADGARGSKGTFLVAYESRDADSRYGWFCTNCKSVDNAMDSMGRIKCNVCENFRKPTEWDAAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWW6</accession>
    <name>A0A3N6MWW6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">ilvD</name>
        <name evidence="17" type="ORF">EA462_08220</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89982">
        <property type="protein sequence ID" value="RQG89982"/>
        <property type="gene ID" value="EA462_08220"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RQG89982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="578" mass="60901" checksum="13E52631FEC3EAA9" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUU9</accession>
    <name>A0A3N6NUU9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87000">
        <property type="protein sequence ID" value="RQG87000"/>
        <property type="gene ID" value="EA462_15255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="128" mass="14382" checksum="DA96316ABE0A2518" modified="2019-02-13" version="1">MSERDPDRDRTQDRAERRASRRADRTESILEDVDRNLGEFEYPITSEELAAEYGSEPIDMPNETESLGSVFDRLAGEQYADPEAVREAVYGAITGESGDRNEANAERDLDRLDEGQQDSRGEDGRGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVS4</accession>
    <name>A0A3N6NVS4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">YeeE/YedE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_14080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87982">
        <property type="protein sequence ID" value="RQG87982"/>
        <property type="gene ID" value="EA462_14080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="7">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="154" mass="16415" checksum="D078296EF8AB67B9" modified="2019-02-13" version="1">MRGRHPLFMPLIFVGGLLFGFGLGFSHMARPEVVLQFLQFEDFGLLFVMGGAAAVTGIAFAVVPRLFDRAPLTGDTYGRRLKSFDRNVLIGGAVFGVGWGLSGICPGAAYASLGVGNVTILWALVGMFVGAYFQGYWRSQRSAAVSGGTNVSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ53</accession>
    <name>A0A3N6NZ53_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86786">
        <property type="protein sequence ID" value="RQG86786"/>
        <property type="gene ID" value="EA462_16765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="9422" checksum="767EF0A109EFBC45" modified="2019-02-13" version="1">MTREDTESVGESLEPAEITERFNELEAGDTVTVNNHELTYDVIDTDTYSVIATDPFGQQVTFSQNLQSGGWTMSETVFDVEHTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ72</accession>
    <name>A0A3N6NZ72_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_16515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86806">
        <property type="protein sequence ID" value="RQG86806"/>
        <property type="gene ID" value="EA462_16515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="3">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="336" mass="36571" checksum="5A88096F6F010E75" modified="2019-02-13" version="1">MSSQGERSEEIADQERIDMLRTMVRIREFESVVQNKFADAEIPGFLHLYIGQEAIATGVCQALTERDYLTSTHRGHGHCIARGLDTDKMAAELYGKETGYCNGKGGSMHIADVNAGMLGANGIVAGGIPIATGAALSAKMRDTDEVAVSFFGDGALSEGAFHESFNQAGIWELPLLGIIENNQYGEMTGLEEHHPPSALDDLTIYGEPYGVTRIQVDGMDVEAVYEATLDAVDQARNGGGPSLIECVGYRFEGHHEGDSQFYRPDGELEEWKQRDPLSTYPEKLIGEGVLTEDGYAEIEAEIEAEIEDAIEFARNSDYPDPQQAYEGVFSDGGEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P150</accession>
    <name>A0A3N6P150_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF456 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91209">
        <property type="protein sequence ID" value="RQG91209"/>
        <property type="gene ID" value="EA462_04255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007403">
        <property type="entry name" value="DUF456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04306">
        <property type="entry name" value="DUF456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="161" mass="16275" checksum="7C6731126A944E47" modified="2019-02-13" version="1">MIDAVTILAVALLVAGIVGTLIPLVPGGLFSLSGLYLYWWHSGYTDPGTVALAVLTALGVMTLLAEFVGGSIAARAGGASWTTTGSAAVVGIALMIVTGPLGLLVGLFGTVFVLEYARGGDIDHSTQSALYATVGVLASTAVQFLLTLSILFGFAVAVVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1F9</accession>
    <name>A0A3N6P1F9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88905">
        <property type="protein sequence ID" value="RQG88905"/>
        <property type="gene ID" value="EA462_10955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="184" mass="21551" checksum="6758505706EE6564" modified="2019-02-13" version="1">MSIDLTEREEQEWLRREAPPLRYSELVSDEEVFQGVKKQLLPHFAAKLEEVLSSDTRDIFVYLREPEYYLIARVALDSASKTTIEEVTNEAKRIASEEDVSAREFAELYMEEMTGALFERVNEMRLRMVAKFIAKNRRNELRMTESGADEDEPDHNSSIDTVKDQSGLRWVEEELPKYKRKIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P466</accession>
    <name>A0A3N6P466_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Valine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Valyl-tRNA synthetase</fullName>
            <shortName evidence="6">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">valS</name>
        <name evidence="11" type="ORF">EA462_09145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90145">
        <property type="protein sequence ID" value="RQG90145"/>
        <property type="gene ID" value="EA462_09145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02005">
        <property type="entry name" value="Val_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022874">
        <property type="entry name" value="Valine-tRNA_ligase_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="70"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="675"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="6">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="6">
        <location>
            <begin position="597"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG90145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="932" mass="106752" checksum="977665C8806C36D2" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4G4</accession>
    <name>A0A3N6P4G4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dna2/Cas4 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92829">
        <property type="protein sequence ID" value="RQG92829"/>
        <property type="gene ID" value="EA462_00965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="2">
        <location>
            <begin position="121"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="371" mass="42460" checksum="5DBAA2B8BB08D2BA" modified="2019-02-13" version="1">MGEIDKETTRAGSSDPNLVDKISGKEFQDWYQEREFRKNIENGKPYFNGPPSVPSPRKHSPSQILQCHRKIAYRQHNAPAEKPNPTGIFWFGSRFEEDLVVKFLKETVVNDQEYVTNSLWVDFTAQTDIGDIQIKGETDPVIVDTDGEPLLLTEIKTKQSVENVRSPNKHHRAQAHAYMKGLSEKYDRTVSEAVILYGSRKTFNAKAFHIEFDPWFWRNTVLKWVETHTTYRLNEDLPPAAPEYSWECSSCSYRERCGRGSASYEDVDATGLLPLHEYPKEVVREYLEGHEDAKVTPTLSERYPELADKFGVHDWRCERCDRTYPHNSPDWTGNVSEPPLCPSCCDDGVPATLRADSIPPQKTGGDRCVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4I0</accession>
    <name>A0A3N6P4I0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90295">
        <property type="protein sequence ID" value="RQG90295"/>
        <property type="gene ID" value="EA462_09975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="13095" checksum="E9ACA6E66EED5B44" modified="2019-02-13" version="1">MSTGVLIVDDSHFMRNLLEQILEQDYRIIGEATNGAEAVKLYKEHDPDIVMMDIVMPKCNGIKATAAIKKIDPSARVIMCTSVGQREKMKLAVKAGADGYVTKPFEEPSVKKALTDVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P560</accession>
    <name>A0A3N6P560_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93199">
        <property type="protein sequence ID" value="RQG93199"/>
        <property type="gene ID" value="EA462_03100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="269" mass="29054" checksum="E4F14B3A3E451A9F" modified="2019-02-13" version="1">METPTRLRTDGPLRATLVAIGLTVFGIAATQFTTLPAFLLEPALIDSPAETSIGMRSAFLALNFLGFVLAGAIYLAATDRGWAYVDLRMPTMRGWLYTLGGIVGSIAFFVAVSLIIQLVSAPTAENQVMDIVGGDQTMVLVMIVIVFFFNAPAEEFLFRNIVQKRLYTAFTRLQSVLVASLIFALVHFPVYYVTADSLVATSVSLSVVFGGSIIFGYLYAKTDNLVVPTVAHAAFNAVQFGLLYLALAYDIEEAEPAPSLFVDAIVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6A0</accession>
    <name>A0A3N6P6A0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91265">
        <property type="protein sequence ID" value="RQG91265"/>
        <property type="gene ID" value="EA462_04550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="541" mass="59421" checksum="C1FA6F04AB9761BF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6T5</accession>
    <name>A0A3N6P6T5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_06430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91585">
        <property type="protein sequence ID" value="RQG91585"/>
        <property type="gene ID" value="EA462_06430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="469" mass="51634" checksum="80AB9DA594033ECE" modified="2019-02-13" version="1">MSTKTPTEEDILRPTHTFTKKYVALFGACALVFGVFLVGWMYQLQQGLVVTGLSDWGTGGGVTWGLYIGAFIWWVGIAHGGIILSAAVRLLGMDRYMPVARLAELLTIAGLSAAGFYILVHMGRPDRMVTSVLGHYHITVNNSPLVWDVTVITAYFVLTATYLGLTLRYDISRLRDQLPSFAPEVGGRQLPDVYGLIYDGMTVGYSEKEDEIIQRMVWWLALAIIIMAPLLLHGGVIPWLFAVLPSYPGWFGAIQGPQFLTIALTSAISGVILISYAFRRAYDWDHIITDDVFRGLLLWLGFFSLLFLWLQLQQLTAGSFAPTVDHADATASKLSHPMYIVPMVMVLGVLAYIFATTIRPSLFSKKRAIVAGVFVLFATLVEKTYFVISGFWYPAFGIYEGTPGDYFPSAIELMSLAGTIGMVTLIFLVVSKLVPVVELHAVEHLRGDHGHGGDHEPADDAATEPEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6W9</accession>
    <name>A0A3N6P6W9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91625">
        <property type="protein sequence ID" value="RQG91625"/>
        <property type="gene ID" value="EA462_06655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="152" mass="17124" checksum="7DA04839E66A9FF2" modified="2019-02-13" version="1">MSTAGSTQPERAQILLVEDNPGDVRLTEEAFKRGRIDNDLHVASDGNEALDFLSQRGSYADVPRPDLILLDLNLPRTDGEEVLKELKDDPTLRSIPVIVLTSSRAEEDIARSYELHANAYLTKPVDPDEFIKTVRAFEKFWFSVVRLPSEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P913</accession>
    <name>A0A3N6P913_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="10">5.4.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glmM</name>
        <name evidence="10" type="ORF">EA462_00265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="10"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92705">
        <property type="protein sequence ID" value="RQG92705"/>
        <property type="gene ID" value="EA462_00265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="7">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="8">
        <location>
            <begin position="149"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="9">
        <location>
            <begin position="255"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="6">
        <location>
            <begin position="384"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG92705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="454" mass="48026" checksum="C7087D730E339CE8" modified="2019-02-13" version="1">MEVFGSSGTRGVANEELTPEFVLRVGKATGTAWGVDRVAIARDTRYTGRMLADAATSGLASTGTDVDRLGILPTPGAQFHAERAGVPVVVITASHNPPQYNGIKLVGTDGVELAVSDLETIEETLLSERFAVAPWDETGRVREITGTTDQYVDELLAAAERETIAGADLTVALDPGHGAGALTSPRFFRELGCRVVTVNGQADGRFPGRDPEPVPENLGDLGELVRASDADVGIAHDGDADRAIFFDEDGEYVPGDATLAALAAAELEAGDTVVSAVNVSQRLVDVVTDLGAELELTPIGSTNIITRIRELEASGARVPIAGEGNGGIFFPAFRLARDGAFTAARFLELVAERSVSEIVSPFDGYANVRHNLEYESTAERDAMLDAAANHAQSADAELNTRDGYRLDYGDAWVLARPSGTEPLVRVYAEARDAGRAQELADELYETLADAKANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P983</accession>
    <name>A0A3N6P983_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92755">
        <property type="protein sequence ID" value="RQG92755"/>
        <property type="gene ID" value="EA462_00545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="114" mass="12351" checksum="716CDA341A317C4B" modified="2019-02-13" version="1">MTDRTRPTWLAYPLTALGAGIGHCYLGEWKRGAMWFALYVLALGFLSARTLTGAFEPGQPFVVSALQLESVNYVDVAVPLAVLLVCLLDVYLIGLTERTATAAARPDDPHRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9G7</accession>
    <name>A0A3N6P9G7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92875">
        <property type="protein sequence ID" value="RQG92875"/>
        <property type="gene ID" value="EA462_01225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="122" mass="13008" checksum="9649F5748C76C145" modified="2019-02-13" version="1">MNVLVGLGGSDESDKTLRRTIERTEAVGDDLTVAVLEKPDTKRSQEETYELAEALLGDADVDAEIVRLEGDPGSSLVDYAEQGEYGQLVIGGGTLSPMGKIQLGSITEFVLLNAPTTVKLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA86</accession>
    <name>A0A3N6PA86_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lipA</name>
        <name evidence="8" type="ORF">EA462_03475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93265">
        <property type="protein sequence ID" value="RQG93265"/>
        <property type="gene ID" value="EA462_03475"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="57"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="315" mass="35259" checksum="F35200F3C67190CD" modified="2019-02-13" version="1">MSSARKPDWLKMRPPSGREFTDIRETLRDRNLHTVCEEANCPNLGECWSGGAATGAGSGGTATFMLMGDRCSRGCNFCDVETGGMEALDPDEPKNVAEAVAEIGLDYVVLTSVDRDDLPDQGAGHFAKTIREIKAQHPGILVEVLIPDFQGEERLVEKIVDADPDVIAHNVETVERLQFPVRDRRAGYEQSLSVLEQVDRESDIYTKTSIMLGHGEYDHEVYQTLADCRDRGVDIVTLGQYLRPSRTHLEVERYDHPDKYETWRRVAEEELGYLYCASGPMVRSSYKAGELFVDAVLREGKSVESARRTARRASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHQ4</accession>
    <name>A0A3N6LHQ4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">serB</name>
        <name evidence="12" type="ORF">EA462_16390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86714">
        <property type="protein sequence ID" value="RQG86714"/>
        <property type="gene ID" value="EA462_16390"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG86714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="216" mass="22789" checksum="A93564BF50D04C49" modified="2019-02-13" version="1">MSVVAFDFDGTLSDSEMTVLLGKRCGVADDMARITERSMNDEIEYAESLRERVALLEGLPETDVAAAFSEVKLRDGAADLLEKLNDAGVTTAILTGGFERGVAVALEREGATVDHIVSNKMPMTDDGKALTGQVEGPLIEGTKDDALEELANTVGTSLTKTSAIGDGANDLPMLEVAGLAIGFEPKPVVEPHCDATVTSMAEAREILVEEGIFEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIT4</accession>
    <name>A0A3N6LIT4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH dehydrogenase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_13515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87876">
        <property type="protein sequence ID" value="RQG87876"/>
        <property type="gene ID" value="EA462_13515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026902">
        <property type="entry name" value="RnfC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13375">
        <property type="entry name" value="RnfC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_51K" evidence="8">
        <location>
            <begin position="20"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RnfC_N" evidence="9">
        <location>
            <begin position="314"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG87876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="365" mass="40181" checksum="8578C533F191A85F" modified="2019-02-13" version="1">MAVNTSIELDPRKIPDRLYEAGVAGAGGAGFPSGAKWEQLEDVHSLLVNHQESEPNYYSDVWLGTEHAAELAAFFDAMLEADLFERIVVGTKQKYRDEWTKEFETACDADVYLEDELPPDLDGETGIIFAYTGETYDFSEEQVLLMMAAGERIGRDLPTDHGWIVHNTETLWNIYNALAENTPVTRKYVHVGGDTPAHRCLDVPVGTTAADLLEAADLPEDALPSDAVLADGGPGWSYAIDESPVAFGTRKRTNAILVLDEATVEAHTEQEDRINVLEERDWNDRDHETQPSVLEPETVSIPLITNAAYEGLVTPGDPVVEPGDRVSTGDVVARRTEDEISNNHHASIDGTVVDVTETHVVLERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJY3</accession>
    <name>A0A3N6LJY3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_10855</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88888">
        <property type="protein sequence ID" value="RQG88888"/>
        <property type="gene ID" value="EA462_10855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG88888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="283" mass="29418" checksum="B5344ECAF49982B9" modified="2019-02-13" version="1">MGALAVRTVVVERDGTGLDEDGGAEDVGLGRDDETGDGGPEKPDAHREQPVDANREPVTFGLEGLRTGFLTATPVALGVGGYGIAFGVLAHQAGLSVAEAALMSATVLAGASQIVAVELWADPIPAATIVFTVFAINLRYSLMGAALQPWFQHLSPKQIYGSLVVMADENWALTMRELASGSGRGAFLLGSGIAMWLCWVASTVLGTIAGSAVGDPARYGFDFVLAAVFVALAVELWDGRSSLHPWLVALVVSVLAAQTIPGRWYILLGGLAAAALEVIRFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK40</accession>
    <name>A0A3N6LK40_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88938">
        <property type="protein sequence ID" value="RQG88938"/>
        <property type="gene ID" value="EA462_11135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="262" mass="28632" checksum="1E8C6FDF488590DA" modified="2019-02-13" version="1">MDVVRRPVSAPTRAPEGETNAYVLGTDPAILVDPANRSDELDRLVRDREIAHVLVTHAHPDHVGAVEAYARETGAAVWARGGRTDRFREATGRRPDRRFSSGTTITLGESSVRVLETPGHASDHVALEVGRNGPILCGDCAVRDGSVVVGAPDGDMRAYVSTLRRLWAIDPPALYPGHGPVIERPRATLERHLSHRHDRERRIEAAVDDGATTLEGILEGAYEKELAGVRDLARATVIAHLEKLVVEDRLEWDGERAGPVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKC9</accession>
    <name>A0A3N6LKC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1616 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89233">
        <property type="protein sequence ID" value="RQG89233"/>
        <property type="gene ID" value="EA462_12780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011674">
        <property type="entry name" value="DUF1616"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014495">
        <property type="entry name" value="UCP018671"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07760">
        <property type="entry name" value="DUF1616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018671">
        <property type="entry name" value="UCP018671"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1616" evidence="2">
        <location>
            <begin position="25"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="352" mass="38739" checksum="DBC0B0606DF0039F" modified="2019-02-13" version="1">MNDDRSPWQILPRSVRIVPADLTAVLAITVVTNVVVFFPFVRESPLRHLCGLVFLLFVPGYTLVCALFPEASRTAGNLRSDRYLRDERDVPRGAGGIRSRAGIDLVERIALSVGSSLMIVPVLGLLVDVSPWPLGLESIMFSVTGFVVCSGGAAAVRRLQLPPDARFRPRPISWSVIRRSKQDEPETRTDTLLNLLLIASIAFAVGIVTVAVVAPAGGEEFSSLTLLTEDDDGDLVAGDYPSEIQRDDGAPFVTGVTNQEHRTTAYTVVVVEQRAQRTESNGTVVTDQRELERFETELGHGESWYHEHEISPTMTGEVRVVWLLYPGDVPAEPSIENTEYRVHLWLNAPPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKD3</accession>
    <name>A0A3N6LKD3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89243">
        <property type="protein sequence ID" value="RQG89243"/>
        <property type="gene ID" value="EA462_12830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="174" mass="19397" checksum="DD5945ECD7C7308B" modified="2019-02-13" version="1">MTDKNRISRRTSLKGIAASSALIGGSILGVNSASATDKNDKKGYDSEKKGKKGKRDRRKEKKKEKGRRKDRKDGKGKKDGKEKRGHDISNYVAFNFEGAKPAKHKAEFYLHHGKDKDLTFTYKVRETGKKGKITVRDTLATAETFWVKAPDGKATVKLYYKGTHVGTASSYPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKQ0</accession>
    <name>A0A3N6LKQ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-3B C(17)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.131</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobJ</name>
        <name evidence="7" type="ORF">EA462_12860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.131" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89248">
        <property type="protein sequence ID" value="RQG89248"/>
        <property type="gene ID" value="EA462_12860"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030789">
        <property type="term" value="F:precorrin-3B C17-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="43"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="295" mass="31869" checksum="0EB8E7DF998B27E0" modified="2019-02-13" version="1">MTDTNADADDESTSNCGASSASGSTRETVGATIEEFDAEPGQLTAVGLGPGHPEGMTERARTALLEAEHIVGYTTYIDLIPTEITEEADELYDTPMCGEVSRTEEAIDRTLAGNDVVIVGSGDPNVYALAGLALEIIESKGATASMVDFEVVPGVPAAQSCGARLGAPLVNDTVSISLSDHLVPMPEIESRLHAVASESFTITVYNPWSRKRRENFEKCCEILLTHREEDTPIGIVHGAGREDEQVMITELGELEELGESEIIDMTTTIVVGNEDTYVWDDRMVTPRGYETKYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLB0</accession>
    <name>A0A3N6LLB0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_13485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87870">
        <property type="protein sequence ID" value="RQG87870"/>
        <property type="gene ID" value="EA462_13485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="68"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="314" mass="34744" checksum="1A6B54EC571CC665" modified="2019-02-13" version="1">MFLTVDAARSRRAARGGCAPRILHSRFTEVFYTALVNIDSQPSIGHLMNSEQHSTSGDVGTTPSSSSIHVEGLAKEYETRNGIEQVFDDVSFTINEGSFVTLIGRSGSGKSTLLSIVSGIQEATKGRVRFESSSGDDITLGHVFQEPRLLPWNTCVQNIEFVHEDNDSFSEELAKEYLDLVGLDGQYDKFPTQLSGGQQQRVGIARALSIDPEILLMDEPFSNLDEITAAELRKELISIWSDLGKTVFFVTHDITEAVELSDRILMLGDGEIYSDISVDLERPRTVDSEEFLTFQQHAIEEFHAIKKTAGADAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLE2</accession>
    <name>A0A3N6LLE2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_07125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89783">
        <property type="protein sequence ID" value="RQG89783"/>
        <property type="gene ID" value="EA462_07125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="20"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="453" mass="48065" checksum="D58B3B8ECA1E3E35" modified="2019-02-13" version="1">MTEDRRLQRNERRLHQPTPIGIEDVGITFGELSVLEDVSLSVDPGEFVGFVGPNGAGKTSLLRAISGAIAPSSGTITIDDTDVHAVSSRTTSRLVAVVPQDTSLSFSFPVRDVVEMGRHPHRSRFSTPTADDRAAVERALERTRTAELAARSIDEVSGGQRQRVVLARAIAQETPVLLLDEPTASLDINHQVETLELVRELVEEDRTVVAAIHDLDLAARYCDRLVLLANGSLHSTGPPSEVLTTETLAEAFDANATVTPNPVTGTTTVTTLPHGATRATDGDRSGEGERTDGGRWGRPHVHIVGSGPAAAGALTRLERAGLEVSVGPVPAGDVAAETAGGLGVDRIEIDPLSTISSRQLAAFDERVRTADATVIADLVVGPTDESRRLLESLEDADPVIVLERRASEELTTGDGAVARRYEGCRDRAHSVAPESLLGTVRDRLGSGSDSVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLH5</accession>
    <name>A0A3N6LLH5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Archaeosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queE</name>
        <name evidence="8" type="ORF">EA462_07390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89833">
        <property type="protein sequence ID" value="RQG89833"/>
        <property type="gene ID" value="EA462_07390"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="49"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="43"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="272" mass="30416" checksum="ED7FC3BED935F4DE" modified="2019-02-13" version="1">MPVSETTDRKAVAGLDGTASESDRDDATTDPNGLPINELFYSLQGEGRLAGTPSVFVRTSGCNLRCWFCDSYHTSWEPTHAWLELSEIVAEIETYDADHVVLTGGEPLLHERSADLLDELASRDYHTTVETNGTIYRDGPIDLVSISPKLESSTPTPERSPSDEDDTSWERRHEADRIDLESFTALIEDTEFQLKFVVTDDGDLPEILSVIAELRDAADVPIRDDDVLLMPEGATRERLAETRGRVAELAMEYGFRYTPRLHVDLWNDAPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLY3</accession>
    <name>A0A3N6LLY3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional oligoribonuclease/PAP phosphatase NrnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89938">
        <property type="protein sequence ID" value="RQG89938"/>
        <property type="gene ID" value="EA462_07975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="18"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="216"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="334" mass="36267" checksum="3F05375C033BA509" modified="2019-02-13" version="1">MSRAVELESTLESAESLAIVCHDNPDPDCLASALALETVARDLGIADVTIAYGGEISHQQNRAFVNMLAISLEPITDTDVGEYDCIAFVDHAQPGVNSDISADTIPDVIVDHHPGETPGATFEDIRTEYGATATIFVEYLRDLEIELTSRLASALLFALHRERLDFVREPTRREYEAALSVYPDADLEALEQLYGSAFSPGTIDAISRAIDSRERRGSSLVANVGKTSETDALPQAADYLLNLEGVDTVLVYGVVGSAIRMSARSIDPRVHMGETLSDGFGELCTVGGHHDMAGGRIELGIFADDMGDADQLIEFIDGRITRRFFDALNLDDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM85</accession>
    <name>A0A3N6LM85_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90183">
        <property type="protein sequence ID" value="RQG90183"/>
        <property type="gene ID" value="EA462_09345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="374" mass="40514" checksum="F6B390D5EDB18325" modified="2019-02-13" version="1">MKLQTIHDGRILATQGRSIHLEPDGTGDIGGREPKRGRLPAPSSAGIGYRLKTTRPARSAVTAITGRFPAVNVWSIDDATLLASADRWLFRSADGGRHWSVVETLPASSAPMGVLPSAVCTADGTTYVGEYPLDGRTTPRILASEDGDTWSTAAELEDVRHVHGVQADPYADELWVTTGDADSECTIGRLRDGGVEPVGGGDQSWRAVELAFTSDAVLWGVDSVYAEHKAIRKLPREHVDDPDPTPETVHRVSSSVYYAETITVDGEQWVCFSTAKEAGADSTGPETQTVHSDRTSVVAASSASGFTDWHELVSYDRRTALADRLNPRQLVPRANAYVFLAGDPDRGLFVNPYNTDRDDGRIRLIPMRAFAELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMA1</accession>
    <name>A0A3N6LMA1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aroA</name>
        <name evidence="9" type="ORF">EA462_10965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88907">
        <property type="protein sequence ID" value="RQG88907"/>
        <property type="gene ID" value="EA462_10965"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG88907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="431" mass="44729" checksum="DD98DC06F39A6BA9" modified="2019-02-13" version="1">MHVTISPSSVEGTIRAPPSKSYTHRAILAAGYADRTSVRDALWSADTRATARAVELFGGDVDRRDGGTLEIEGFDGTPGVPADVIDCDNSGTTMRLVTATAALADGTSVLTGDESLRSRPQGPLLEAITDLGAQAASTRSNGQAPLVVTGPISGDAVSIPGDVSSQYVTALLMAGAVTDDGLELTLETELKSAPYVDITLELLEAFGVDARRTDDGFAVEGGQRYGAESGEYAVPGDFSSISYPLAAGAIAGENGVRIEGAQPSAQGDTAIVEIVDRMGASVDWDRDAGTIDVTTGSLEGIEVSVENTPDLLPTIATLGAVADGDTRITNAEHVRYKETDRVSAMAEELGKMGVETTEEPDSLTIHGSDSRLEGATVEGRGDHRIVMTLALAGLVADGETTITGAEHVDVSYPGFFDALEGLGASLERRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNW2</accession>
    <name>A0A3N6LNW2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87887">
        <property type="protein sequence ID" value="RQG87887"/>
        <property type="gene ID" value="EA462_13570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="109"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="363" mass="41392" checksum="B9269336A6C800BB" modified="2019-02-13" version="1">MASFTVTDADAHYLEDLSRLSEYLEDDNPWKGRFGGDSKDNREDIGSVPVNIFPASTGSRNLYGRIQRDEVSYPGEEMSGEDVPRIMAHLGLDNCVLLSQKMLTFARLKADDERANVLAKTYTEYMLDEIVDPDEGVYTMIPVPWQDPEYAVELLDEYGDEKGICGACMITGGAEPPMGNRKYDPIYEIAEKKDLAINFHTGGGGLDEFHQKGYEKFIETHTLGFLYNNASQIVSVVVQGVPEKFPDLKIAFQESGLFYVPTVMHRLDAEYLKRQSEAPLLEKRPSEYMQEFYYGIQPMELPEKEEYLEQIIEMIGGPDRLMYASDYPHWDYDRPSVITERPFLDDDEKRRILSGTAEEVFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNX4</accession>
    <name>A0A3N6LNX4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Single-stranded DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91093">
        <property type="protein sequence ID" value="RQG91093"/>
        <property type="gene ID" value="EA462_03585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="433" mass="46616" checksum="C78E6A532974EB93" modified="2019-02-13" version="1">MELDSHAEDLASDLGVDKEEVKADLKNLVEYSVPIDEAKGSLRRKYGDGSSAGSSTPSARNLGDVTPDDGSVTVTGVVLTAGERSIRYQGDDQVIVEGRLADETGVIDYTAWEDFGLSPGETITAGNAGVREWDGEPELNLGESTSLSFVDESLDVDYEIGGDAQLAELQTGDRAVSIEVSVLECERRTIDGRDGETEILSGVFGDESGRLPFTNWDPAPEIEDGGPVRIENAYVQEFRGVPEVNVSAFSTVSALEREVDVGADATTMEIGDAVRTGGIYDVEIVGNLIAVRDGSGLIQRCPECYRVIQKGQCRTHGDVDGVDDLRVKAILDDGTGTVTVVLDDDLTEDVYDGTLEDALEQAREAMDQEVVADTIRERIVGREYRVRGHLSVDDYGANLDAETLEESADDPTTRARAFLEEFGADAEATEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP38</accession>
    <name>A0A3N6LP38_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88007">
        <property type="protein sequence ID" value="RQG88007"/>
        <property type="gene ID" value="EA462_14210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045361">
        <property type="entry name" value="CIS_tube_prot_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19266">
        <property type="entry name" value="CIS_tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="161"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="211" mass="23605" checksum="A5129AA022CE64B9" modified="2019-02-13" version="1">MSGSLERAYITILDGSNAGTKLECAFNPNEYQLNRQAGYGEHRTALNAPIQQFTNGVADTLTVELFFDTTETQADVRTEYTDVIDSLMAVDGKLHAPPSCRFVWGNGLAFKSIVVEADKRFTRFRPDGTPVRAWVDVTFKQHADPKQQKRRIKHESTDKTKLKTVSEGDTLWLIAAAEYGDPSHWRTIAEANELENPREIPPGTKLSLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP49</accession>
    <name>A0A3N6LP49_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gas vesicle structural protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_07530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89857">
        <property type="protein sequence ID" value="RQG89857"/>
        <property type="gene ID" value="EA462_07530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00669">
        <property type="entry name" value="GAS_VESICLE_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="186" mass="19791" checksum="329F4F40D515B2D9" modified="2019-02-13" version="1">MVDDFQPSRQKTDLAEVVEMLLDKGIVINADIAVSIGDTQLLGVQVRAAIASFETAAKYGLEFPEGTDMRRVAEAVDDPEILEQERPNPAIDPTRGVNVSPDKRSDDERAEADEGGDENADQRANSRFERSDRGTERVGARPDPDRPTGGGFDMVGEDTETGHDGGDGGDESNAGDDAAAAKTEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP63</accession>
    <name>A0A3N6LP63_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxypeptidase regulatory-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91208">
        <property type="protein sequence ID" value="RQG91208"/>
        <property type="gene ID" value="EA462_04250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="312" mass="33247" checksum="DB5E9F66BBE0687F" modified="2019-02-13" version="1">MFEPIPGDHCMTYNRRTILNRTALAGLSLFGVAGSAPTAAAEPDDTLVEGTITDFDDPVAEATVSLGDATTTTDEDGEYELTVDPADSDGTDRSAVSVSGERVLEVRADGYAERTRRLEIDPGEAVSADVPLYREWGDETGELQVYATEVDGGSTIPCHVTIYGDDTYEASAPEGAIPDSGSWNTGFAVSEGWWDVRVTDAAGYADGTQTVYVDADGSEIAWVQLESGDREIPGTGRVLGRVVDERGDELDEASVRIAGEPVSVDDDGSFEIDLEHGRHPVTATARGYESLRGGVDARFGRTTELIVPLESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPK2</accession>
    <name>A0A3N6LPK2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91418">
        <property type="protein sequence ID" value="RQG91418"/>
        <property type="gene ID" value="EA462_05455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="211" mass="22922" checksum="1E6B7531CFEC1B24" modified="2019-02-13" version="1">MYGDGDGAGSVDQREGSDPVDLPSILAQLDEQTRATQRDAVRTVRRNVREQPERCMPTVPKLRQLLEEPSVDFNDEIAFCLAELAEESVNDVVPSVDGIVSFVAENPSSAAVPDLLRSLETVSSEHPGAITEHLESIVPALEVDDTRTRATAVVVIGRAASEVDTAAGETVDEIRSSLEERTRDDPDSSVRDRAEWALEQLPCSPPCRVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPQ7</accession>
    <name>A0A3N6LPQ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88874">
        <property type="protein sequence ID" value="RQG88874"/>
        <property type="gene ID" value="EA462_10780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="72" mass="7531" checksum="BCAFCB8BC280587C" modified="2019-02-13" version="1">MTDEDVPTATLPSDERREATLRDCPVCGAGISVVSVLGPLEATAMPCGCRVSPAVLRGSPVGFDSRLGRDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPU6</accession>
    <name>A0A3N6LPU6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90217">
        <property type="protein sequence ID" value="RQG90217"/>
        <property type="gene ID" value="EA462_09535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="68" mass="7959" checksum="D6115E8D1FAE4D61" modified="2019-02-13" version="1">MDENRTVVDILERVRESRRHRRCPDCEEVCVIRGFRGEYRWECSNCESLGIGYATRAAALDGIRNRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ03</accession>
    <name>A0A3N6LQ03_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90297">
        <property type="protein sequence ID" value="RQG90297"/>
        <property type="gene ID" value="EA462_09985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="150" mass="16158" checksum="684314526365722C" modified="2019-02-13" version="1">MSSPSSRDERAAESDRITVLPFSLGGTRYCVRVDAIESVVGVAKAGLLENAADPWAAGSTAVDGTRVRVVDLLRVIEPARSRTDDPTLLVCRETDERGAHYGWVVGTVDSTETVRTDDVVTASASAQFIEGRIERPDGAVIWLNDREING</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ55</accession>
    <name>A0A3N6LQ55_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="1">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90367">
        <property type="protein sequence ID" value="RQG90367"/>
        <property type="gene ID" value="EA462_08720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023010">
        <property type="entry name" value="GcvPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42806">
        <property type="entry name" value="PTHR42806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="446" mass="48833" checksum="0D8BBA200101D744" modified="2019-02-13" version="1">MTRTDDERKGTPFAPHTDDEVEAMLEAVGVDDADELFDIDASIRFDGEFDIDAATEQTVTRELTETLARNDDAVEFLGRGHYSHHIPSLVDHISLRSEFITSYTQYQPEVTQGFLQVLFEYQSMLVELTGLEIANCSMYDASTALGEAATLADRVRSTSGSRVLVPDYLRSERRDVLENYVEGAGLTVEEVRTEEGVTTPDAIERAIDDDVVMAYLESPTTEGVIEEHLEEIGGLVDDHDAMFCLGSDPVALSLLRSPASVGVDVVIGDASVLGMPASYGMGLGLFACRKEYLRQVPGRLVGASEDADGNRAFTLTLQTREQHIRRERATSNICTNQAWVALRTSIHAASLGPSGLVSLAEQCHNLAERTATRLDEIDGVSAPVRDRHHFREFRAHVDDADAVVEALSADGFAVHAIDEGTIQLCVSDVNEHRIDELTAAFEEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQB9</accession>
    <name>A0A3N6LQB9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2795 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89144">
        <property type="protein sequence ID" value="RQG89144"/>
        <property type="gene ID" value="EA462_12290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="95" mass="10483" checksum="E75DCE3B137138B8" modified="2019-02-13" version="1">MLRNRTGEAIDDHEYPATTDELIEEYGDHVLELPNGSESVNDVLARLESETFEDSHEARLAIYSAVSRKAIGRVGYSDRDPTPVGSPYAPDAVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRS1</accession>
    <name>A0A3N6LRS1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_07565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89864">
        <property type="protein sequence ID" value="RQG89864"/>
        <property type="gene ID" value="EA462_07565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040699">
        <property type="entry name" value="XPB_DRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18458">
        <property type="entry name" value="XPB_DRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="131"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="365"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="494" mass="54815" checksum="F077B2BDB8C9A7A2" modified="2019-02-13" version="1">MAVRLRSEDVTRSSDGASTVELRYEDGTIRIDGLEDEPALARSVRDAIPELDVDPRTDGFRVPAFRYAELRGALAGSGRAIDDRVRSFDGSLPALESAYELREYQYDALSAWLETDRWSSNGGSSEALTTATRATVAPAGVLELPTGSGKTVIALYAIERLAVPTLVVVPTIDLLEQWQGELEAEFGVSIGRFGGGEQRLEPITVSTYDSAYLKADSVGDRFALVVFDEVHHLGGEGYREIARLLSAPARLGLTATFERPDDAHEVIEEIVGPVVYHLEPDDLAGEHLAPYDVKQLEVELTPDEREAYDRNQEIFTNYLARSNIRMQRGSDYQELVKRSGNDPEARHALLARQRAREIMLGSDAKIEALEEILADHRDERTIVFTAHNDLAYDVSERFLIPTITHQTGAKERRGILERFRDGTYTRIATSNVLDEGVDVPDASVAVVLSGSASEREFTQRLGRILRPKSDGGRALLYEVISAETGEKRVSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS94</accession>
    <name>A0A3N6LS94_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arsenic resistance protein ArsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_00585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92763">
        <property type="protein sequence ID" value="RQG92763"/>
        <property type="gene ID" value="EA462_00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="26"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG92763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="414" mass="42233" checksum="4E69D76AC26D72CF" modified="2019-02-13" version="1">MFGLEAGPVATGVVLATFALLFVRRIGRYPVSRSVTAATGTVVLLALGIVSPQRALEAMSVQTLLLLFGMLVHVTALAQSGFYEWTATQLVTAARTPRRLTLGALALSALLSSLALNDATVLLLTPVLVVAAERGGTDPVPPVLAVVFGANIGSVATPLGNPQNAFILAESDLTTLEFIAALAPVAVVCLLIAGAFLLPKTERGRILETPVSSDVVRSGTDEGGFDRAWAATSVAFVLGTFVLLVALPDVGVGTIAASTAIVHLAWLQGFRRVAGDDVFADVDWSVLVLFGGLFALVAGLDGTALLEAVEAVSGGSQLAIATFGLSNLVSNVPAVVLLAAAIPEAATADWLMLAAVSTLAGNATPIASAATLLTLEAAADMEVRVPLRELLVLGIPLSIVTSVIAVGMLSVMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSI1</accession>
    <name>A0A3N6LSI1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92903">
        <property type="protein sequence ID" value="RQG92903"/>
        <property type="gene ID" value="EA462_01390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="188" mass="20460" checksum="48452C17700C323A" modified="2019-02-13" version="1">MSVSDRVRRLTPSERSDERTDAVDESRLEHASRAAVRGLQAGFVATVIMTAFRLPILRSLPPSANFWAQYVSGGDPEDHPVAGLLLHVVYGVQAGAIFGALFALQDAERSIEPEQRGLVWGGVYGMALSAFGSQIMLKEALDIRLENDELALFHAGHLVYGLALGAWVGSRTEGVDDPETEYEYDDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSK8</accession>
    <name>A0A3N6LSK8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_01580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92938">
        <property type="protein sequence ID" value="RQG92938"/>
        <property type="gene ID" value="EA462_01580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="6"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="29053" checksum="2C7F3997FA479AD6" modified="2019-02-13" version="1">MLSVGFRTLFRRELLRFIRRPKNTFMPPAITNVLYFAVFGVILGGRIDEPVAGIGYILFLIPGLIVLGTISNAFENASFSIFHGRWNEYIHETLTSPLSYAEMVTAYVAASAVRGLIVGLIIALIGRLFVPISVENGLFLVATMVVVAALFAGLGIIGGLVARDFDDLTVMNQFILRPLVFFGAVFYSLTMLEPAWQYVSLLNPMVYMVDSVRYGLLGYSDMLEIAPAAYADIAPLLSLSVLALLTAVVLTLDVYLFKIGYGLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSR9</accession>
    <name>A0A3N6LSR9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91597">
        <property type="protein sequence ID" value="RQG91597"/>
        <property type="gene ID" value="EA462_06500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="119" mass="13391" checksum="AE7BB69FD7BE7214" modified="2019-02-13" version="1">MSEAQSITGEQSIARELTAFQNNILVILAKEPMYGLAIKRELEEYYGTEVNHGRLYPNLDELVELGLVEKSELDKRTNQYSLTDDGYDAVLDGVSWALSNVVTGDDRADEVRDIVDESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSU0</accession>
    <name>A0A3N6LSU0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91627">
        <property type="protein sequence ID" value="RQG91627"/>
        <property type="gene ID" value="EA462_06670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="98" mass="11373" checksum="3A1ED6799A707F1A" modified="2019-02-13" version="1">MTEYRRNRSVNECLVRVEVDEHEQPSVAVIRAIEQATSDEPAEMRPLFEFVSPESLDRLFVDTNSTTRRGIVEFSLERFEVRIVDGQYVELREHGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LTA8</accession>
    <name>A0A3N6LTA8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93288">
        <property type="protein sequence ID" value="RQG93288"/>
        <property type="gene ID" value="EA462_01295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="82" mass="8931" checksum="805D6DCA5714A8CF" modified="2019-02-13" version="1">MIQTDVADENCVSQTVVEAIAEAEGTDPLELTPPLYEVIDPDALENLFTDGKTVGKIIFNYNNFEVCVFSDDSISVETTVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUV3</accession>
    <name>A0A3N6LUV3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91384">
        <property type="protein sequence ID" value="RQG91384"/>
        <property type="gene ID" value="EA462_05270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="129" mass="14667" checksum="992212A32E15A411" modified="2019-02-13" version="1">MATGLLTDEATEQIETTCRTAIGDSLRSVTYFTRDDYEQVYLREDLERDADLSTFIGHEWRGFKTAQTAYENSELGEYNYTIRVFDNGFLIRVTNDSEGVFATTDGLTVKDFEEVATALSSFLETRQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWX5</accession>
    <name>A0A3N6LWX5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_17370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000012">
        <property type="protein sequence ID" value="RQG86087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86087">
        <property type="protein sequence ID" value="RQG86087"/>
        <property type="gene ID" value="EA462_17370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="6">
        <location>
            <begin position="73"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="330" mass="35343" checksum="E5CDA74221B5A673" modified="2019-02-13" version="1" fragment="single">ERLEQKATEFGRVMGIAADGDLTQRLDDDVDNEALAEIAAAFNEMLEELERTIVDIQSLAGDVDHVSGDVTTRVEEIEKASAEVSRSAEEIATATAEQSDRFQEVYGEMNDLSATVEEIASTADNVATVSSQAADQAEVAGDASSEIRSEMDRLEERAESITTQIEQLDDEMGEISEIVDMIDEIADQTNLLALNASIEAAAAGEEGDGFAVVASEVKSLAEETGEATQEVDDLVTSVQSSVDETVDEIERMREQVDDGGEVVDEGIDAIETITDQVETTNESIQSVNDATDEQARASGRVVTMVDEATEISEETNAETETVAAAAEEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LX35</accession>
    <name>A0A3N6LX35_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative selenium-dependent hydroxylase accessory protein YqeC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yqeC</name>
        <name evidence="1" type="ORF">EA462_16995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86167">
        <property type="protein sequence ID" value="RQG86167"/>
        <property type="gene ID" value="EA462_16995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017587">
        <property type="entry name" value="YqeC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19842">
        <property type="entry name" value="YqeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03172">
        <property type="entry name" value="TIGR03172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="253" mass="26948" checksum="B98697323F1E9290" modified="2019-02-13" version="1">MDVLEALCAESGLVAVVGAGGKKTTLYTLAERAAREGHRSVVTATVRIPIFDSAVERVAITEEPLETLERSERWPVGVVPEREREDRYLGYDPSVIDELAAADTAGPILVKADGARTRDLKAPDEHEPQLPRTVETVVPIASVQVVGAPLTADLVHRPERVAAITGRELGAPIRATDVARVLASDRGGLSAVPEDATVVALLNKVDDSDDRAVGTEIASDLLDRTDRVSHVVLARMIDDDPIVDVVHAGNGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LX62</accession>
    <name>A0A3N6LX62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylaspartate mutase subunit S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_17160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylamine corrinoid protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86197">
        <property type="protein sequence ID" value="RQG86197"/>
        <property type="gene ID" value="EA462_17160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019670">
        <property type="term" value="P:anaerobic glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02072">
        <property type="entry name" value="Glm_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006394">
        <property type="entry name" value="GlmS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01501">
        <property type="entry name" value="MthylAspMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="146" mass="15730" checksum="2321BB689260262B" modified="2019-02-13" version="1">MSQTVVLGVIGSDAHVVGITILEQAFSAAGFDVVNLGVQTSQEEFAEAAVAHDAGAVLVSSLYGHARQDCQGFHDVLESAEIDAVTYIGGNLAVGQDDFERTRETFRELGFDRVFDSETDPEEAIAALRRDLQIRPTETERVTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXY8</accession>
    <name>A0A3N6LXY8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86148">
        <property type="protein sequence ID" value="RQG86148"/>
        <property type="gene ID" value="EA462_16890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="328" mass="35392" checksum="DC7B87EAF291FC9B" modified="2019-02-13" version="1">MVLHFRKATSIFRKTMPFVLLRMGVGILLGLVTVLYFGVILWFGLSLLDSGTLSGPIAGVGLLVAVVLFVGAWRLAARYILYMVKAGHIAVIAHIVETGEVPPNQFQYGKERVTEHFTEASALFAVDALIKGVIKQFNDGALSFAKSFAVVPALRQLIQIVGKAVAIAASYIDEAIIAYMFTNPDKNAWTAARDGVVLYGKNWRPVLGSTMLIVLGMYAAGLGVLLALTPLANVLGNLSPALEVTGWAVVGGLFLTIYVGFLKPWVKTVVITTFLIEAGETSPDSATMDRIADRSEKFTELMSKADEETPDDRSEQPDRTPVTGAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXZ9</accession>
    <name>A0A3N6LXZ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92704">
        <property type="protein sequence ID" value="RQG92704"/>
        <property type="gene ID" value="EA462_00260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="357" mass="39933" checksum="DB900A6655D81DB5" modified="2019-02-13" version="1">MIERDSDDGEEPPASQPDPLVGSESHIDDLLHWLYLDGDRRLLTGWLLLFVFGACLLLIRVDLITPAEAGDITAIAAALVGGMLPFITVVLAINQLILSEEFGTTGVFIERLEETREYRYGIEDHTGYRPSPVEPSAFLRVLIESKRRTALGLWNVCRDAPVALREAIDDYVSTTTPRDVDAIERLEGASFGTFTVIAVIVHYNDPWQLQSVRRIRSRHRHDLSDAAENQLDRLEELLRDIHVARQYFKTVHMQQELADLSKILLYVGFPTLLGGAFVIVAYGNLLALELNPIVYAIVVSTTITALFSPFAVLLAYVLRIATIARRTAADFGPFVLQQQIPGEEIETADETGYRRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYX4</accession>
    <name>A0A3N6LYX4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87903">
        <property type="protein sequence ID" value="RQG87903"/>
        <property type="gene ID" value="EA462_13655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="1">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="467" mass="47714" checksum="673577CB2BB9C112" modified="2019-02-13" version="1">MTDRAIAGVGAYVPSDRIAAQEFTEALGTFGGTGIQQKSVPAVDEDSLTMAAEAATIALETTGIEPESVDGLSLATTTPPMDEEDPTPRLASMLALDDDVETTLHTGSTLAGVEALTTGLERDGDDATLVVASDAPRGAPDSAIEHAAGAGAVAFVLTDDGAATVVDRGTASEPYPGTRFRAHGEPETASLDATAYERASFNDLLSAATANLETDSIDAAAVQAPNGKLPYRAAGSLGVETGDIQACATVHDVGDVGAASALLSLAVAVDDDAERVLVAGYGSGASATALLVENDGVDATLEIDADGEGLSYAHYLRRRGELTSGEPDGGGAYVSVPTWKRSIPQRYRLDAGRCPDCGALSLPPDGACDGCGALVEYESVRLAGTGTVEAVTTIQQGGAPPEFVEQQARDGAFQSAVVAFDGPGGETVSLPAQVIGEVDVGDAVESTIRRVYEQEAVIRYGLKVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZC9</accession>
    <name>A0A3N6LZC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93274">
        <property type="protein sequence ID" value="RQG93274"/>
        <property type="gene ID" value="EA462_00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="300" mass="30901" checksum="7FB6075DB6430973" modified="2019-02-13" version="1">MDSIEEKRVYGDRDGALEAYVTSSIGVVRVRVAGDTVGEFGLCERCDARDVTATDDVVAIATEEDVRVYDLESGVGSAEGTDDEPTFAETGFGSAVAVGADGPDLIAAGDDGRVARRRAGTDRWEPLAADAVGGADSERPGIGTVRAIDGDLVGTETGVYRIHDGGLDHAGLTAVNDVSTPGVPLAATDDGLYKLGNGWMEILEESFESVTADPRSEPGRLVRAHATAGDTIYALEGGEWHATGSAGAPIVAIRYGETVYAVTEDGGFCATGEGGWRTHPLGIDGVTGLAIAAARSDSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0N4</accession>
    <name>A0A3N6M0N4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89200">
        <property type="protein sequence ID" value="RQG89200"/>
        <property type="gene ID" value="EA462_12605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="419" mass="44765" checksum="2B9616552FF6E29A" modified="2019-02-13" version="1">MTTPVKRRRFVQTLGTGTVIAGAGCLGGSGDGNGDGNGNGNDDHDHGDHENGDDDPEGDAEGSEGLAYAFAPNTIAIIDPETGDVVDEITDGIDGNEWGDPQITHDLTQIFVIEGSLNQVLVIDTDSREIVSEVDIGPGATHIYHPNDDEIWAHADDEGTFYVIDTDSHDVVETVEAGLEGEGHGKLLYHEDFGSMGYATNVNDPVAHVIDLGEYDRPDSIELGEDGGTHYKAYAPQNGLAYFEYSDVTAAVDVDADEVVDELEFSGGMYLTPDEERMGVLDGDEIRFIDVTDEENEEIGSVTVDGGPDALRYYESDGTLYGFTANTMTPESVVIDVDELEEVGRLDAGDIERPDGAHHLHRSGVSGDEYFFTPAEADGTVAVIDMAERELIGTVEVEDGVGTVQYVGDTGTGYTGGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M231</accession>
    <name>A0A3N6M231_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89850">
        <property type="protein sequence ID" value="RQG89850"/>
        <property type="gene ID" value="EA462_07490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="163"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="338" mass="37885" checksum="DF64FA02E0538B4A" modified="2019-02-13" version="1">MDVTRIGLEDWRDALPSSGYEFFHDPDALSVLDDHTTADLRLYGAYKGQQSVGLLPVFVGEKSLGTTALSPPLSLGVPRLGPLITPNSPKPRKAERINRELATAVVDDLAADRRSTLFRMTCPLEYTDPRPYAWNGFTVEPQFTYVVSLEDCDDLEDVMAGFSKSLRNEMRRYDEIDLTIDTEGIDAALRVYDDVVAQYEEYGDTAPMSRPFLRDLLSTVDDDRWRVYVARTPDGAYQSAILTLYSPDLASYWQGGVTASYEHVSVNNLLHRAILEDLVTDPELDSITGYDLVGANTERLCEYKGKFNGELSPYYVIESSGLEMSIAKSAYRKFSSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M250</accession>
    <name>A0A3N6M250_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89181">
        <property type="protein sequence ID" value="RQG89181"/>
        <property type="gene ID" value="EA462_12505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="105" mass="11705" checksum="77142D3315509CEF" modified="2019-02-13" version="1">MTTTADRPVRPAHRSTDDLSSHVSRVDAGGRDERRVSEARTVPGVEDETPRTTPNRPLGLRWRILSNRPNDRRDDRSPAGIRGSTRIDGQFGRRTTAFSGPELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M267</accession>
    <name>A0A3N6M267_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89201">
        <property type="protein sequence ID" value="RQG89201"/>
        <property type="gene ID" value="EA462_12610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="175" mass="20182" checksum="83F8BC5067F1CCB8" modified="2019-02-13" version="1">MNDTRGQIRAHVRANAGIHFNELVRESEFAPGQIQYHVRRLIDDDDLVRREFYGRTHYYPPTYDEWERAALALFRRETAREIVVYLLESPSSDPGSISADLGIARSTLEYHLERLVGQEIVEKSYDDRNRVSLRLVAPERTATLLSVVEPTVPDRLVDRFTRLVDSVLESSPDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2I3</accession>
    <name>A0A3N6M2I3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MaoC family dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90020">
        <property type="protein sequence ID" value="RQG90020"/>
        <property type="gene ID" value="EA462_08420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="153" mass="17423" checksum="CF70C6978E11A131" modified="2019-02-13" version="1">MSGRYYEEFTVGETIEHGRRRTISESDNQRFCDLTMNQQPLHLDREFARESAFGERVVNGLYTMSLAVGIAIPETTDGTIVANLSYDEVSHPNPVVHGDTIRVTSTVTEKRETSDGERGIVTMHLKVFTQNDDLVCEFDRTVLSLKREHEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M373</accession>
    <name>A0A3N6M373_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90310">
        <property type="protein sequence ID" value="RQG90310"/>
        <property type="gene ID" value="EA462_10055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="97" mass="10604" checksum="82331CFB1125CF21" modified="2019-02-13" version="1">MLLSVDRSEKDSVRSLSFEVIEAVAEREGVDPTDIEPPAYDALYDAINPEALDALFAPRADGTERTTGHVEFTFCNYRVTVSSEGDVVVHGDESDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M394</accession>
    <name>A0A3N6M394_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdenum cofactor guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86163">
        <property type="protein sequence ID" value="RQG86163"/>
        <property type="gene ID" value="EA462_16970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="5">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="230" mass="25037" checksum="0751A29D90AD4F8E" modified="2019-02-13" version="1">MAVHSRERPSETDRTTSNEPSSTTSGVIVAGGFSERFGDQEKALVPVDGKPMLARVGNAVAPAVDELVINCRAEQRPAFERALEQSGPALALEVRFALDRSDERDQGPVAGLRRGLEAVSGTTAVAVPCDLALLEAEFVAQLVGEYDRVTDTDAVVPYADDYSQLLCAVYDVAATQIACERVLETERRRLFDVLDHLAVTTIDDVESWTDPRRLRAIDTPDALAACRDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3R2</accession>
    <name>A0A3N6M3R2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89851">
        <property type="protein sequence ID" value="RQG89851"/>
        <property type="gene ID" value="EA462_07495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043914">
        <property type="entry name" value="DUF5763"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008634">
        <property type="entry name" value="Gas-vesicle_GvpO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19067">
        <property type="entry name" value="DUF5763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05800">
        <property type="entry name" value="GvpO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="178" mass="20134" checksum="81228AB2A966A168" modified="2019-02-13" version="1">MAEADTKRSPDQCQALTEDGERCSRPAQDDGFCYQHDESDSTVSDSQTVDEREQDDDQNAQQRSRDLSVDMTAEEKTDPESVDADVDTDHEEIEGVLAVRKTVQSTATELIGREFDGVSEIVPTDDGWRAIVEVVERRAVPDTQDIIGRYEIELDEGSTIHGYRRLDRYRRGDTAEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M443</accession>
    <name>A0A3N6M443_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chemotaxis protein CheA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86917">
        <property type="protein sequence ID" value="RQG86917"/>
        <property type="gene ID" value="EA462_14755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="CheX" evidence="3">
        <location>
            <begin position="248"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="398" mass="43124" checksum="1C22800225EEFC52" modified="2019-02-13" version="1">MKIDIHSLETYNELARDGAESAADALSELADVPARVEMTDVSLMSSSDLRYEFDGRTFAGVSVSLGSPLSGETVLVFDEDGREAITSNLVPAAGPERLESAVVEVGNIMANGFVSGWADHLDTKIDVSPPSPVEGDGASVLPDPTTADDEYVFVFRSRVRSADSDVDFRILLFPAIDALEELLEDRTGEGISLEKLEVFTEMTKQGAVRATDNLTAMTGLETTVEVNRLNFVSIPDIPAQVGTEQRVGTAVKYTGSPSGYLAILFQPASARRNVDALLSNEHDGDWSERERSALEELCNVTASGFIDGWANVLETSIRHSPPTFISDMGSSIVSPLIADLGRTDNYAFVLDSTIETEDADSLQCQLLALPRRDELEEALEALLVERVTETRADPDDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4A7</accession>
    <name>A0A3N6M4A7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_08660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90061">
        <property type="protein sequence ID" value="RQG90061"/>
        <property type="gene ID" value="EA462_08660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="302" mass="33197" checksum="0D94BF7673EB661E" modified="2019-02-13" version="1">MISFVHTYFHNFLEEHTRYRRIYARFRRNTLAMFGLYFTIIYVIVAIVAPLIMPYDPGSTDGARRLLAPSLEHPFGTDRYGRDVFSRVLYGTRISLRVAALVVTIATVTGVVTGLVAGYYRSWVDEAISRTVDVFFAFPNILLGLIVVAILGPGLNQIILALGIAFAPIMTRITRGSAISVREEEYVLAAKSYGEHSFNIMFREMLPNMVSAVMVQATIIFAFSILAEAGLSYLGLSAQPPTPTWGVMISEGQRNLQTAPWISLFPGIAIMSTVLGLTFLGVGLRDALDPKTDVDADTTGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4E6</accession>
    <name>A0A3N6M4E6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-ketoacyl-CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90101">
        <property type="protein sequence ID" value="RQG90101"/>
        <property type="gene ID" value="EA462_08880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="252"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="388" mass="39794" checksum="B2EB4184D2920546" modified="2019-02-13" version="1">MSPVRVAGAGLTPFGNVPERTGRDLFAEASTIAFEDSGVEREDVEAVFYGNFMGELSEHQGHQGPLMAEAAGVRAPATRYESACASSGVAVRDAVFRIRNGEADVVLVGGTERMTNLGTAGATEALAIAADDLWEVRAGMTFPGAYALMAQAYFAEYGGDREGLAHVAVKNHENALPNEKAQYRSEITVEDVLEAPQVSSPLGLYDSCPISDGAAALVLTSEAYAEEHGLEAPVAITGTGQGGDRMALHDRDYLARSPAASEASEEAYADAGVDAGDVDVAEVHDCFTIAEVLAIEALGLESVGEGISAARDGRTTADGDTPVNLSGGLKAKGHPVGATGASQIAEIAALLAGTHPNSEFVEGATTGVAHNAGGTVASATVHVLEVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M524</accession>
    <name>A0A3N6M524_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91110">
        <property type="protein sequence ID" value="RQG91110"/>
        <property type="gene ID" value="EA462_03680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="96" mass="10848" checksum="CD284949246FE68B" modified="2019-02-13" version="1">MCRELRREPSWVAAIRLAFLQGRVDVESVVEEANLVPGKERTVRDVLSTMAERGVLEELDGRDCYVPGPVLVESDRYDLDFERATDGGAHRWNSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M639</accession>
    <name>A0A3N6M639_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YihY/virulence factor BrkB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_05935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91500">
        <property type="protein sequence ID" value="RQG91500"/>
        <property type="gene ID" value="EA462_05935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="260" mass="27104" checksum="438D5AAF14EDA590" modified="2019-02-13" version="1">MVAKETLTSIYRTATDRDITFLAAGFAYYAFVSLIPMVLLALVVGSLLGGEDVAQRLVLVAGDFLPEAGEALVTDALTTEAGRAEATVVALVVAAWGALKVFRGLSLAFDKVYDEVSEDSLTEEVRDGLTVIVAGAFALALMVVVGAVLGLVAGSIPFGGVVGWVALLVGLVLVFVPIYYVLPPVPVDLTEVLPGAVFAAVGWTILQAGFQLYAANAGRYQAYGAVGAVLLLVTWLYFAGIVILVGAVLNVVRSRPLIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6J7</accession>
    <name>A0A3N6M6J7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cob(I)alamin adenolsyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91710">
        <property type="protein sequence ID" value="RQG91710"/>
        <property type="gene ID" value="EA462_04965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="229" mass="24757" checksum="E53E208BFB81590C" modified="2019-02-13" version="1">MSEDQSRDATLENTPGQGRTPTAERIDPSAPEEFGLVQVWWGDGKGKTTATLGMGVRAAGHGYRVHVLQFMKGGASSVEAVRGEYNAIEALPGISYENLGHYGWHGMADGSDEAGHEDKARAGLERAHELLEAASEADLGTAFDLDGPPEAGVHMLVLDEILYAVDQGLLAEADVLELIETKPNDLELVLSGSHAEPTYLEERADLVTNVRKQKHPIDEGQRARRGTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6P5</accession>
    <name>A0A3N6M6P5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88996">
        <property type="protein sequence ID" value="RQG88996"/>
        <property type="gene ID" value="EA462_11460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="145" mass="16239" checksum="D9043F7D67F782C2" modified="2019-02-13" version="1">MIIRGKDMAVSLLAVGTAAVAGYLLRSSRSRDDSPRSKADLGARLVDRDEIPADATVVDVSSRRLDEIPGARRAIERAVRNRAREDWEHVTLDRGGAWSVVDAIRDSLPYYDGSDSRYNGVYVHYENRFVVLDAIGWARLEESLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6T1</accession>
    <name>A0A3N6M6T1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89036">
        <property type="protein sequence ID" value="RQG89036"/>
        <property type="gene ID" value="EA462_11690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="260" mass="27615" checksum="7D83BE17EAF523F3" modified="2019-02-13" version="1">MDLELTGNAALVTASSSGLGLASARALAEEGANVTICGRSADRLESARAELDGAAGEVLAVRADVTDPDDVSRLVTETVDAFGGLDHLVTSAGGPPSATFIETDDRDWYRAYDTLVMSVVWAIEESRPHLLESPSGTITCITSRTVREAADGLLLSNAVRRGVTGLIQTISREFAPEIRANAVLPGTIETPRIEELVEARIESGVYDDYRDGLEDLASEIPMERIGEPRELGEVVAFLSSPHSSYVNGAELAIDGGLMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7X4</accession>
    <name>A0A3N6M7X4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type II toxin-antitoxin system RelE/ParE family toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91451">
        <property type="protein sequence ID" value="RQG91451"/>
        <property type="gene ID" value="EA462_05655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="99" mass="11959" checksum="7FBB5E9A45A67362" modified="2019-02-13" version="1">MAHEVVLTETLVETLEQFETDDAERIINKLEDIGDFPNHFLDRLKNHPGYKLRVGDFRVLIDWDKENEVIYAIDAFERKKEYRELGKYREVWGSWRDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8Y7</accession>
    <name>A0A3N6M8Y7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PGF-CTERM sorting domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">EA462_00350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
            <location evidence="2">S-layer</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92720">
        <property type="protein sequence ID" value="RQG92720"/>
        <property type="gene ID" value="EA462_00350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030115">
        <property type="term" value="C:S-layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011493">
        <property type="entry name" value="GLUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026371">
        <property type="entry name" value="PGF_CTERM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07581">
        <property type="entry name" value="Glug"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04126">
        <property type="entry name" value="PGF_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0701">S-layer</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="854"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="12">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glug" evidence="12">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="452"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="818"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="488"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG92720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="875" mass="90672" checksum="E32DBB384CA3A383" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9E5</accession>
    <name>A0A3N6M9E5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92910">
        <property type="protein sequence ID" value="RQG92910"/>
        <property type="gene ID" value="EA462_01425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043461">
        <property type="entry name" value="LpxH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990">
        <property type="entry name" value="PTHR34990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="11"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="454" mass="51513" checksum="2548421B8D2077B2" modified="2019-02-13" version="1">MATETDDRVYYVISDLHIGGDEQLEEVDFLDELLAFLEGLETTDENAELIINGDAFGLWEFTTVDGIEKFEMLEETYPELFEQLRATGENTQITLLPGNHDHELAAYDEYVERFGAYNVDLVPEQSINRSVGGQAIHFEHGHQRDSNNRIEDWGNPHSTPLGYYYNTLVTSRAGHLSDRGRYNWLKDVQAVTPTERMPVWLFSKYFYREMNPLLRYSLFPFLLLFNISAILAVVVGLDLVGVWSIPIDEAVTFLGQFGRAGTAAWFALALNIGVAGLLLLVGIPLYFIRRDIRKTIDRFGVFETELTVDPEAPYEEAAREVFDEQPETSIFCYGHTHRPTIRTVDGGVLVNSGTWLKRLHRRDGIIGILPPVFYPSYQLAAVRIADEPEGVAIEFEQITKPSPATTELTRTERFFTVGREPEPELPDRHVIEDDSTPENAKVRVTTPESQTNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9F6</accession>
    <name>A0A3N6M9F6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90156">
        <property type="protein sequence ID" value="RQG90156"/>
        <property type="gene ID" value="EA462_09205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="70" mass="7517" checksum="51D515088F159CC3" modified="2019-02-13" version="1">MCVTVDVKGEGTYEIDLATDGDSSPTYTDLLHEVDLSPHEVSVLVDGRPVPEDQPVDADHVTVLRLIKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9Q1</accession>
    <name>A0A3N6M9Q1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arsB</name>
        <name evidence="4" type="ORF">EA462_02115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93030">
        <property type="protein sequence ID" value="RQG93030"/>
        <property type="gene ID" value="EA462_02115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="385" mass="41606" checksum="C2BFF336C0EE3652" modified="2019-02-13" version="1">MRDAHDHGPNCDCGSCGDPRAMDVLDKYLTVWIFAAMAVGVGLGYVAPGVVDPIREYSLVELGLILMMYPPLAKVNYRRLPTVFSQWRILSLSLLQNWLIGPTVMFLLAVIFFSGAVPWFPARPEYFLGLIFIGMARCIAMVLVWNDLADGSSEYAAGLVAFNSVFQIVTYGVYIWAFALVLPPLLGLDALASGISAFDITTMQVFEAIVIFLGIPFAAGMLTRFGGVRARGEAWYADELVPKISPLTLLALLFTIVVMFATQGDAIVAQPTDVLWIAVPLTIYFVVMFLVSFAMGRGIGADYSTTTAIGFTAASNNFELAIAVAVAVFGIGSGVAFATVVGPLIEVPVLLALVHVALYFGRRFDWDGFETGRLDGSPSETTTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9R1</accession>
    <name>A0A3N6M9R1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93040">
        <property type="protein sequence ID" value="RQG93040"/>
        <property type="gene ID" value="EA462_02170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="197" mass="21485" checksum="62B40556EE1DDD33" modified="2019-02-13" version="1">MRELDETDLEILELLTEDARRPYREIAEAVGLTPPAVSDRISRLSEQGIIRGFTIDVDRETLHGETPVLVELAPTPATVDEVYADARSLEGVETVFEGADGRVVVHATLPGTDVRAWLGEHLDLEMLSSYDVTVLSRSDRITGVTATGFALECVVCGKEVVGDGVTATVGGEVKTFCCPSCEDRYVSRYESHRDALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9R3</accession>
    <name>A0A3N6M9R3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90286">
        <property type="protein sequence ID" value="RQG90286"/>
        <property type="gene ID" value="EA462_09925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="212" mass="22634" checksum="79940C3D9030B57B" modified="2019-02-13" version="1">MRTGRTRTPEATAQRGQVYTLEGLTAAAVVLFALLFAMQAVVITPGTGGAVDRTAQAQNQQELQDALIVAAHADDGEGTLSELVRYWASESEFTARTFDEDFADQFVLGEILDSHLAGSGAGDRYGLEFVYLNESEPERTGVAGSTTTDPSAVTASYTVTIYEGQNMTTLENGAVEPIAENGAIDEEDSRLPPSESSSGPVYNVVEVRVTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MA07</accession>
    <name>A0A3N6MA07_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93150">
        <property type="protein sequence ID" value="RQG93150"/>
        <property type="gene ID" value="EA462_02805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="153" mass="16769" checksum="1198E72B4A8A84EE" modified="2019-02-13" version="1">MVLEPGENAPTVTALDQDGEDVELAFDAPTVLYFYPRDATPGCATEARQFDRELEEYRDAGVSVYGASTDDVDSHREFRDDEGLDFDLLADPDGELADAFDVDRTRGATERTTFVLADGEVQSVYEGVDPDGHAREVLEDALEDGLVTLSELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBP4</accession>
    <name>A0A3N6MBP4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinylglutamate desuccinylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_01330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92891">
        <property type="protein sequence ID" value="RQG92891"/>
        <property type="gene ID" value="EA462_01330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG92891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="283" mass="31378" checksum="97355E295849110C" modified="2019-02-13" version="1">METNFGPLDVTLRGPGEPEVVVVAGVHGDELSGIRAVRRLREIDLDLQRGVAFVLANPAAIEAGERYLDSDLNRVFPGDPDGDREERIAARLCEFVEGRTSLSLHGTEADPTPFALIHSAQEREFELASELPVPHIVDHWGVNERTITTCGFTVEIELTSTDSEEATEAAQHQTRAFLQRVDALPGEPPDADPDYFHMDKPIPKPDGDSYELHVENFEHVPEGTVYATVDGDDLTADESFWPIIMSAEGSEDIFGYQGRKIGESIEEVKETWINSDREPRNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBW9</accession>
    <name>A0A3N6MBW9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_01785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92971">
        <property type="protein sequence ID" value="RQG92971"/>
        <property type="gene ID" value="EA462_01785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="291" mass="31208" checksum="0D7BFA131BA475B6" modified="2019-02-13" version="1">MSSVDVESVRAIATKDFRDSIRSWVFWGLSVFFFTLLVTVTGFLAYFGEDIAAQGATTAALVGYVSEITRLVIPLIALILGWKAIAGERESGSIKVLLSLPHSRTDVILGKLIGRSTVLSVSLLIGFTLAGAIVAAMLGSFDVTDYAGLLAVSILYGIAYTSIAIAVSSLTRSTTIAGAAVFAVFVLFYIVWDAVVGAVSLLMALDYLPQGENTAQAVLFYQSLDPGTAYTSVLSLVTSVAEMDGQTVAMLETMFDAVPFYLTDWFALVVLLFWIVVPTAVAVYRFDRVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCE6</accession>
    <name>A0A3N6MCE6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91396">
        <property type="protein sequence ID" value="RQG91396"/>
        <property type="gene ID" value="EA462_05335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="101" mass="11270" checksum="C88D48AFF471E381" modified="2019-02-13" version="1">MTERRICESDGYLLDRCLTYDRGVDESPSVAVVTALARYHGESVTETSTNLYEYVDPEALDALFTDTRRGVERSADRVEFEVEDVTVVVTSTRVEVSPTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCX3</accession>
    <name>A0A3N6MCX3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydroorotase</fullName>
            <shortName evidence="3">DHOase</shortName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pyrC</name>
        <name evidence="5" type="ORF">EA462_06605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91616">
        <property type="protein sequence ID" value="RQG91616"/>
        <property type="gene ID" value="EA462_06605"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_A">
        <property type="entry name" value="PyrC_classI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="4">
        <location>
            <begin position="53"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="3">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="455" mass="49905" checksum="7D21D4E650251330" modified="2019-02-13" version="1">MSVDLVVRNCTVVTPAGRSSNAGVAVEDGTIVAVGKSDRLPDGDRTLDVDGATVVPGIVDCHIHNREPGLEYKADWESATRAAAAGGVTTVVGMPNTDPVIDRPEHLELKYERGETSAHVDFQSYAVVTSENLDLIPELDEAGVLGYKIFLGSTVGDVPPPSDGEIIEAMERIRRTGKRLGFHEENGEIIEYYTELFKAEGRNEPIDHSHSRPVIAEREAVERMITFAEGTETKIHMFHVSSGSAAEAVARGKDRGVDVTAETTPHYLWFTEEVMHEKGNPARIQPPIRDADERDRLWKIGIDDGVIDCIATDHAPHTDEEKLVDDPFGNTWDAISGFVGLETEVPAMLTFVDQGRLTLEEWVRRHSTRPAQVWGMYPQKGSLQIGTDADFTVVDPAATWTLEDRHELHSKNCVTPFEGESFTGKPVATAVRGEIVFEDGEVIGEPGYGTRVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCY1</accession>
    <name>A0A3N6MCY1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HdeD family acid-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91626">
        <property type="protein sequence ID" value="RQG91626"/>
        <property type="gene ID" value="EA462_06665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="198" mass="19979" checksum="C2AA63AABD0F12F7" modified="2019-02-13" version="1">MNTATVDDEPSGYSLERGWRTLAIAGVAVGLIGLIAIAFPLATGLSVTIGLGALLVVGGIVHGAHAYTARGWSGSLWQLTLAVVSIVAGIVLLTNPVIGLATLTILAIAYLLVDAVAELWLSMRMADRPGRLSVAASGVLSLVLAGLLWAGFPADAAWAIGLLVGIGLLATGLSMGIVAINGRNADETMSGATEPRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFY0</accession>
    <name>A0A3N6MFY0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92826">
        <property type="protein sequence ID" value="RQG92826"/>
        <property type="gene ID" value="EA462_00950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="425"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="772" mass="87232" checksum="19716B7CB2DE38E1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MG43</accession>
    <name>A0A3N6MG43_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA large subunit methyltransferase E</fullName>
            <ecNumber evidence="2">2.1.1.166</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">23S rRNA Um2552 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">rRNA (uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rlmE</name>
        <name evidence="4" type="ORF">EA462_01355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42720"/>
            <dbReference type="Rhea" id="RHEA-COMP:10202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10203"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.166"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.166" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92896">
        <property type="protein sequence ID" value="RQG92896"/>
        <property type="gene ID" value="EA462_01355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="3">
        <location>
            <begin position="198"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="258" mass="28263" checksum="30447AB55990E60E" modified="2019-02-13" version="1">MTGRDHYYNKAKQEGYRSRAAYKLKQLDDLENVLSRGDTVVDLGAAPGGWLEVAAEAVGTEGTVIGVDLQRIKDFDDHDTIETIRGDMTESRTRERVIDAAGGSVDVVISDMAPNMSGEYSLDQARSLYLARQAFETALELLDSDGDFVVKVFEGADVDEFRADVGDAFQYVRATSPKASRDESSEIYFIGKGRLTAPVRSGDELEVEIVDVGDEGDGIASVEGYRLFVPGTETGDVVDVRIEDVKPNFGFANRLNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGQ7</accession>
    <name>A0A3N6MGQ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conditioned medium-induced protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93156">
        <property type="protein sequence ID" value="RQG93156"/>
        <property type="gene ID" value="EA462_02840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="196" mass="22419" checksum="0EB9E1092040D594" modified="2019-02-13" version="1">MNEKTEELRDIFTDVTDGEATVTESQENTRGSLEKDERTEEDRLETVVSQMRDRYEFETTLSDEELIHVARGFYDGDRDDVIADRVGGGPTEVFEARLSLHLVDEDDADEVDLAAIRERDEDTATLAEEYDVSNEQIERYRRVASAKDESRAANDRYRDEFDSILADAELSERMTTDVREDGLEDATEGMETNVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MQS3</accession>
    <name>A0A3N6MQS3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86169">
        <property type="protein sequence ID" value="RQG86169"/>
        <property type="gene ID" value="EA462_17005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="156" mass="17935" checksum="3B2902D00A1E2829" modified="2019-02-13" version="1">MSHTADDVFDDPFAEQREMRELLSQETRHLIVQCLLGHPHHLASLAELTYMIQKNEGAVLDQLETLQEAGLLDVYVHEPNISTRDLPSRFWGPTERGVDVLYEHNFLRGVPVARAVYEETNKSEKVRRHETAPRPSLPDAVREALQFEEPVPEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRR2</accession>
    <name>A0A3N6MRR2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Energy-coupling factor transporter transmembrane protein EcfT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_15000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86963">
        <property type="protein sequence ID" value="RQG86963"/>
        <property type="gene ID" value="EA462_15000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="234" mass="25431" checksum="6C99F6BA960D18F0" modified="2019-02-13" version="1">MLTYKPDQTIAHRLDPRSKLAVQLGFAATALAHTSHRALLALSLVCAFVLFVARVPLFETLYAYRFALVVLATAPLIAAVTLGPPWFDASDGLASARASYRVLLILLVSTAYVRSTPVRHSRAAIQRTVPGKPGQVLGIGVALVFRFLPVLQGDLRTIRDAMAARLGTERNALERLTTIGLLGLTRMFERADRLSLALRARCFAWNPTLPMLSFSRLDVPVVIGAVALALTAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MS98</accession>
    <name>A0A3N6MS98_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87103">
        <property type="protein sequence ID" value="RQG87103"/>
        <property type="gene ID" value="EA462_15865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="124" mass="12710" checksum="30CDED8DDD2D4D9D" modified="2019-02-13" version="1">MTTGPKLRLGGALAPGILAVILFAMMGAIALNTQFGQMSGYPEGISITSEIGYAMFDLSPLQSTEEAMANTESFLAAFLLIAVALDAALDASLVLAKREEGDGPVAPLSTQSSGATERTGGDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSD7</accession>
    <name>A0A3N6MSD7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2071 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87143">
        <property type="protein sequence ID" value="RQG87143"/>
        <property type="gene ID" value="EA462_15770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018644">
        <property type="entry name" value="DUF2071"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39186">
        <property type="entry name" value="PTHR39186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09844">
        <property type="entry name" value="DUF2071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="223" mass="25334" checksum="97CEC950E4DB90BB" modified="2019-02-13" version="1">MGWRHLLFENWPVDPDVVSPHVPDALELEEHDGSAWLSVVPFTNVAVRPTGVPRSFGIRLPELNLRTYVTRGGVPSVYFFSLDAQGVSSVIGARLFYHLPYYYARISLSPEDDRIRFKSRRRHPGARPACYEGTYRPSGEPFSAPDDPLGEFLVERYRFYTQAQDGSIRYTDVDHEPWTLYPAEAEIETNTLLSAHGFERPAADPVYHYSPGLDVTTSRSERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTU6</accession>
    <name>A0A3N6MTU6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PstS family phosphate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_10380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88802">
        <property type="protein sequence ID" value="RQG88802"/>
        <property type="gene ID" value="EA462_10380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PBP_domain" evidence="3">
        <location>
            <begin position="63"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="348" mass="38298" checksum="DEFE1068387158F7" modified="2019-02-13" version="1">MPTEPIADRAVDRSRRRVLLGAAGATLAGLAGCIARGYESDLEGEIRMDGSNTVLPHGAVVSEEFQWRNNRVQIPVRGSGTGAGFQRFCDGETHVQNASRPIFDDGGEDEGALCTANGIEYVELETALDGLAVFVHPDNDWCDCLTVDELARIWETGSDVERWSGVREGWPDEEIELYGRDPASGTFDYFTENITGEVGNIRSDYSASADTNVIVRGVRGSQYALGFGGAGYYYENEDELELVGVDNGEGCIEPTKATIESGDYEPLTRPLYTYFRADALAREEVRSFARFYFEEIDGEATEADIVEPGESLTWTQWAARRVGYYAIPDDQIDDRRETLAGAIAEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MX07</accession>
    <name>A0A3N6MX07_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90022">
        <property type="protein sequence ID" value="RQG90022"/>
        <property type="gene ID" value="EA462_08430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="3">
        <location>
            <begin position="107"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="218" mass="23736" checksum="43D5FF55362F2A0B" modified="2019-02-13" version="1">MTDRSRSNNGRQPVSGTGPSHDLQPSTEAHGSLEWLALIREGGSAPGETIVWRDGPRMQTAYPWGALALVGVLVPLVTIALDIFSALALVWAPVVSIPAVWGVLRIARTEYVLTSRRVAIRRGVLGISVETVDLERVQNTTLTQHSVARIVGYGTVTIEAASGETFTLRNVEKPDAVRNRLEAQRELGRSTDVPGAIEQWEAVLEEIRGLRRTIDPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXC2</accession>
    <name>A0A3N6MXC2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="8">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tyrS</name>
        <name evidence="10" type="ORF">EA462_09185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90152">
        <property type="protein sequence ID" value="RQG90152"/>
        <property type="gene ID" value="EA462_09185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02008">
        <property type="entry name" value="Tyr_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023684">
        <property type="entry name" value="Tyr-tRNA-ligase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="38"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="212"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG90152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="328" mass="36741" checksum="D9143D7877C39907" modified="2019-02-13" version="1">MDTYDLIMRNAEEVVTDEEVRELADDPAGKRAYVGYEPSGVLHIGHLLTANKLIDLQEAGLDVVVLLADVHAYLNGKGTFEEIRDTAERMKAQFIAYGLEEDKTEFVYGSSFQLEEDYTLDLHELELSTTMNRAQRAMAELQSGETAKVSHLVYPLMQVLDIEYLDLDLAVGGLDQRKVHMLAREELPELEYDARPCLHTPIVADLTSGEGKMSSSEGATISMEDSTEELEEKVNSAFCPPTRDPEGDLENPVLELFEYHVFPRFETVVVERPEEYGGPLSYEAYDSLADDLESGELHPADAKGTLASYLDELIEPGRRTLRELRAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXE0</accession>
    <name>A0A3N6MXE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90172">
        <property type="protein sequence ID" value="RQG90172"/>
        <property type="gene ID" value="EA462_09290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="189" mass="20625" checksum="3D3BBC6AB2547BE9" modified="2019-02-13" version="1">MTDRVTRRTALLLAGTAGVTALAGCGGPGEEGEADDEPSADDLGEAEPEEDTDESETEEDTDESEENGEPDEETGNGEWADVGEFYFEGRIEAWSGLEPEMIADEDNPTITLIEGQEYDFRWVNADDVVHNLEIRDENDEVVDDYVSDDVGEEGEETTLEGVVASEEMAVYICSYHEAAQAGDIEVETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXN6</accession>
    <name>A0A3N6MXN6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Twin-arginine translocase TatA/TatE family subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_09900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90282">
        <property type="protein sequence ID" value="RQG90282"/>
        <property type="gene ID" value="EA462_09900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG90282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="105" mass="11578" checksum="6FDEB2D0346835D9" modified="2019-02-13" version="1">MVAEIAPLFIPGAPGGPELLIILFIAILLFGANKIPKLARSTGEAMGEFQKGREKVETELEDMRDGDFEELDEDEDTEFVDTEPVTTEEAETDAEIETDTETETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4Y4</accession>
    <name>A0A3N6N4Y4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_03460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93262">
        <property type="protein sequence ID" value="RQG93262"/>
        <property type="gene ID" value="EA462_03460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="28"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="232"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="821" mass="89769" checksum="AD9BFD8E2AEEF79B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NV46</accession>
    <name>A0A3N6NV46_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87140">
        <property type="protein sequence ID" value="RQG87140"/>
        <property type="gene ID" value="EA462_15600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="115" mass="13020" checksum="754502189B81FC16" modified="2019-02-13" version="1">MTDEADADEILALLDDQYAQVILQQTRNNAMSAKEISEICDISISTVYRRTERLVECGLLAERRVAQPDGTHYSLYEARLDELTVRLTDDGFKITVSEKATGDLADRFTDMWEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ73</accession>
    <name>A0A3N6NZ73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YhbY family RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_09490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90209">
        <property type="protein sequence ID" value="RQG90209"/>
        <property type="gene ID" value="EA462_09490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="82" mass="9171" checksum="34CD12D52BDE6ABE" modified="2019-02-13" version="1">MDREERMRRAHDLDVTVWVGKSGIESVVDELDDQLTNGDLVKVKFLRAARAGSSTDETAQDLADRVNADLVDTRGHTAVLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZT7</accession>
    <name>A0A3N6NZT7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ORF">EA462_15825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87096">
        <property type="protein sequence ID" value="RQG87096"/>
        <property type="gene ID" value="EA462_15825"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="134"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="288"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="408" mass="43970" checksum="4FE9418EE1562C3D" modified="2019-02-13" version="1">MAAHCRRFWESLSADTDNRPAMTTLETPGSTVGVVGGGQLGRMLAEAASPLGVEIVVLDPTPDCPAATVARDQIVADFDDGGGIRQLADRSDVLTFEIELADQTALEQIGEETGTPVHPKPSTLETIHDKLVQKRELADAAIPVPPFRAVEDAEDIRDAIDDYGAPVMLKARTGGYDGRGNVPVESKADADAALESIAGPAMVESFVEFEREVSVIAVKGDGEVATFPLGENVHVDEILRETIVPARSSETATERAYEVARDVLSAMDGRGVYGIELFETPDGEILLNEIAPRPHNSGHWTIEGAQSSQFEQHVRAVLGWPLGSTELRSPTALANLLADVEESRDAQLRNVDRVLETPGANLHWYGKREARPGRKMGHVTVSGRDEGATVEALLETARELERAVTFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P114</accession>
    <name>A0A3N6P114_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91169">
        <property type="protein sequence ID" value="RQG91169"/>
        <property type="gene ID" value="EA462_04015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="6703" checksum="43F97D554A8F4039" modified="2019-02-13" version="1">MDDVEQSVELRRLKVRIVALEVLTDRPFQDRLDVVSIGVAVQEGVTNVLVLNRLAARRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P163</accession>
    <name>A0A3N6P163_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH</fullName>
            <ecNumber evidence="3">2.1.2.3</ecNumber>
            <ecNumber evidence="3">3.5.4.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purH</name>
        <name evidence="3" type="ORF">EA462_10340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="3"/>
    <dbReference type="EC" id="3.5.4.10" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88795">
        <property type="protein sequence ID" value="RQG88795"/>
        <property type="gene ID" value="EA462_10340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="2">
        <location>
            <begin position="21"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="546" mass="58572" checksum="FD7EFC30DA36D849" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1B6</accession>
    <name>A0A3N6P1B6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91279">
        <property type="protein sequence ID" value="RQG91279"/>
        <property type="gene ID" value="EA462_04640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="164" mass="17138" checksum="300851CD9E49BC9D" modified="2019-02-13" version="1">MTVHGYATRRSVLTALCGAAAGSLGGCAGLEGGRDPSYEAGSIPDVDDERTAEEMTAATGLADQEPSDAVTPLGSLSLEDHEFVLEDGASGATVQGTVENAGDDRIHLVEIRVRSYDESGDQLGRYLDRTGDLDGGSRWSFEVVLLESVDDLDAYDVAVLGTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1E9</accession>
    <name>A0A3N6P1E9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MgtE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_04875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91319">
        <property type="protein sequence ID" value="RQG91319"/>
        <property type="gene ID" value="EA462_04875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="PTHR16228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="MgtE" evidence="7">
        <location>
            <begin position="49"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="189" mass="20392" checksum="8ECD65DF46282A94" modified="2019-02-13" version="1">MSVRREFWSIYREALPILLIALGGGLFAGLVLERIIESVERFPGLLVMVPVFLATRGNVYGALGGRISSGLHQGLIEPRFSWDDRLVNAVLASFVNGIGISIVIGVVTWSALLLLGWEPAALYELVGIMLIAGVLTSVILIFGLLALIFAGYTRGYDPDNLVGPIVTTLGDIFGMLFMLFSIAIVEVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1K0</accession>
    <name>A0A3N6P1K0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA double-strand break repair nuclease NurA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91389">
        <property type="protein sequence ID" value="RQG91389"/>
        <property type="gene ID" value="EA462_05295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="74"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="423" mass="48430" checksum="CCFEB7BCCCE2A085" modified="2019-02-13" version="1">MTLDPVHYDGIAKLARRIDHGASERDRREFAETVWENFLDPLRSDARTVMEPVDEQGRRVVDCEDVALCDRKFPTQHGLDAGTINPTAFKNGLVIDIAQAAMSTTPSDLEIHRSRTTVMTVHSNDETMTVDENWGAFDEGYSRSRAVKIPPLPRFAEGVVHALALYLAESKHALEHAADVSDLLVLDGPLYPRGLLRWADQHPDLSDFLLEDPRPTTVLENYVRLVETLVEREIPLVGFVKNPATRLITRTVTNRRDVDVSVPWADDTALFTRLLERGEYVDDVDGERWERDTDALSYTNWFRSRGGVDRPLSIDGDALGVDRHLESDRYEVTFFVVYDPRDDLIYRVEAPYAFTRDPDTRERLTMQLLQDVAVAHGPPTIIEKADELARISRAEKRSLRETLETQFDTSRTRNYDDHRWEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1L5</accession>
    <name>A0A3N6P1L5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Acidic ribosomal protein P0 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl10</name>
        <name evidence="2" type="synonym">rplP0</name>
        <name evidence="5" type="ORF">EA462_05405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91409">
        <property type="protein sequence ID" value="RQG91409"/>
        <property type="gene ID" value="EA462_05405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00280">
        <property type="entry name" value="Ribosomal_L10_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022909">
        <property type="entry name" value="50S_L10_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="RL10_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="RL10P_insert"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RL10P_insert" evidence="4">
        <location>
            <begin position="114"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="349" mass="36897" checksum="761446A6D6285BEB" modified="2019-02-13" version="1">MSAQAERKTENLPQWKKEEVEELQNLIDDYESVGVVGITGIPSKQLQDMRRGLHGTAVVRVSRNTLQVHALEDAGLDDLVTHVEGQVGLVATDDNPFTLYKELEASKTPAPINEGEVAPNDIVIPEGDTGVDPGPFVGDLQGIGANARIEDGSIQVMEDSTVLEAGGEVSVDLANVLNELGIEPKEVGLDLRAVIADGVLFDPDDLDIDVEAYESDVSTAVARARNLSVNASYPTATTASTLIAKATGEAKSLGLHAAIEDEELMPDLVSKADAQLRALAAQIDDEEALPEELQNLEAPVPAAGDADEVEDESADDQDEAEADEADETDDEDDDEDDGDGAEGLGAMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1S4</accession>
    <name>A0A3N6P1S4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_11800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89055">
        <property type="protein sequence ID" value="RQG89055"/>
        <property type="gene ID" value="EA462_11800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="8562" checksum="230B5ABF77189B86" modified="2019-02-13" version="1">MIESTPELANLVLESHAANEHTSAAAAAIAVGLAALGAGYAERGIGAAAVGAIAEDDDMFVPGIVMTVLPETLVIFAIVVIFLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3D7</accession>
    <name>A0A3N6P3D7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_07135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89785">
        <property type="protein sequence ID" value="RQG89785"/>
        <property type="gene ID" value="EA462_07135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026469">
        <property type="entry name" value="Peripla_PGF_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04281">
        <property type="entry name" value="peripla_PGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="68"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="414" mass="43782" checksum="F6402F4685D1C3C6" modified="2019-02-13" version="1">MQYGRVLLVVALLIVATTVPVVGAGASPSAAADPAPSVAQSIDATCEYPLERTDARGETISLEAEPDEVVTLYPGDAQLAFQIGAEDRVVGMPVGQYTDGLEAGDRTDISADDGVTPVAEEIVALDPDVVLAANVALTDEDFIEQLEDAGIAVYVLDTATSVDDVRENVEVAGELTGTCDGAEETVAWMDDRLAVIEDALEDVDEPLAYYVSDDEGTTPGTETFQHDVLTSAGLENVAERAGIDDWQTISAEVVVEEDPDWIVYPDWIDEPPVEEGIEATTAMEDGNVVSVDDNAMSQPAPEIVHVVTALLETVHPDVYADLEADLDSIDERYDVDTEVGTEDVISDVGYETDDEPSADDGSDSSDDAQDATDEAEALDGEDDDEGAFPVPGFGIVATVIVLCSILAVYGLRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3P6</accession>
    <name>A0A3N6P3P6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89945">
        <property type="protein sequence ID" value="RQG89945"/>
        <property type="gene ID" value="EA462_08010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="169" mass="18515" checksum="A308DD56CF65EAE4" modified="2019-02-13" version="1">MNRRRVLQSAGALVAISFAGCLEGVQDHFEGGVQGIVPIEIYSEADQYYNVQLQAYEHETNRQTYDEGYSVTGGDSVIPPHLEATRQSLRVVKFGADGEEQADVREVTITPETELVLIWIYDDDLVLDVHRGDVDGAANETPTPPDEEDVEDDTADSDDPGTNGSEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4J2</accession>
    <name>A0A3N6P4J2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90315">
        <property type="protein sequence ID" value="RQG90315"/>
        <property type="gene ID" value="EA462_10085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="258" mass="27372" checksum="BDBE80B7D4C2897E" modified="2019-02-13" version="1">MNRRQLLLASGVTLTSAVAGCAGETDDENGNGNGNGNGDDSDPEPEPDDAGESPEEDSPEPDDDPEPDDDGSDGDEDDVDEPDPQSFSGSGAAVEDGVRIIGNLTVVEAEHDGESNFAVHLVDDSDHDDMFVNEIGTYDGETAELVEQGEYMLDVEADGDWSVDVRQPRAASGDELPQSLSGDGNQVFGPFEFDGTHVAEGEHSGESNFSTHVYPAEGSFGELVFNEIGEYEGETTFNFDGIGWVAVQADGDWSIELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4W3</accession>
    <name>A0A3N6P4W3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93049">
        <property type="protein sequence ID" value="RQG93049"/>
        <property type="gene ID" value="EA462_02220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="261" mass="30778" checksum="1CF12FB0B92FA051" modified="2019-02-13" version="1">MMLEGFEFQSECINPHLETGGRNEYLCLSDEGDIQTGIGQLAKEIFIQGQNQSNLNTEATLKVDFVKDGNSRRTGPDWLKNNFTRSEQEKIIDRRRQMFHNYGVLFHMILWPGATNYFPEIGRFVNPMGNIRSSMKYNISKNFDRLVKDIYSIDQRNERWFRDKKIYELKKYKPSIQVLTIQVDNPTFKLDGGGMMCKEVYNMKVDIRKNIQKDRRDYIYGTCVHATDEFKHNIHVERVLSEIENGEYNPEKSTEEFQNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P5Y7</accession>
    <name>A0A3N6P5Y7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-monoxide dehydrogenase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91105">
        <property type="protein sequence ID" value="RQG91105"/>
        <property type="gene ID" value="EA462_03655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018492">
        <property type="term" value="F:carbon-monoxide dehydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012780">
        <property type="entry name" value="CO_Mo_DH_lsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02416">
        <property type="entry name" value="CO_dehy_Mo_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="48"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="833" mass="90260" checksum="8587032EEDE87717" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P626</accession>
    <name>A0A3N6P626_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91165">
        <property type="protein sequence ID" value="RQG91165"/>
        <property type="gene ID" value="EA462_03990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="101" mass="11662" checksum="682B33CD4EB3289B" modified="2019-02-13" version="1">MIDRLEKEVDMLERHLQVLRMVIENEPIGIVKMSNETGYPHHKVRYSLRVLEEENLIEPSSQGAIKTERTAEFVDELDGKIDDIIDKLEGMKIEDVAEIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9V3</accession>
    <name>A0A3N6P9V3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translation initiation factor 5A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Hypusine-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">eIF-5A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">eif5a</name>
        <name evidence="13" type="ORF">EA462_02390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Functions by promoting the formation of the first peptide bond.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93075">
        <property type="protein sequence ID" value="RQG93075"/>
        <property type="gene ID" value="EA462_02390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00085">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022847">
        <property type="entry name" value="Transl_elong_IF5A_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="Transl_elong_IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="PTHR11673"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 11 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF-5a" evidence="12">
        <location>
            <begin position="69"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="Hypusine" evidence="11">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG93075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="124" mass="14023" checksum="4DEC78E451E6F35B" modified="2019-02-13" version="1">MAKQQNEVRDLQEGSYVMIDDAACRIDAYSTAKPGKHGSAKARVEARGVFDGKKRSFSQPVDAKIWVPIIERKQGQVVSVDGDDMQIMDLETYETITMRIPDGEDVSPDDEIEFLEMEDQRKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA01</accession>
    <name>A0A3N6PA01_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_02780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93145">
        <property type="protein sequence ID" value="RQG93145"/>
        <property type="gene ID" value="EA462_02780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="250"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG93145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="508" mass="56188" checksum="E2207BBE62F2C7EB" modified="2019-02-13" version="1">MQLPESQVAVVEAASADETTAVDALAAATDLPPETVTGAVFELEEDGLVVVKERVDETSRLTDEGETYADDGLPEVRLYEAALEAGADDDPASMGRVIGASGLEGSQVDIALSNYARKGYGAIDSGELTADPDADPAADAEANALEELAGTDDTPLEVVDVDGETMGGLERRGLVEIAETTVREVRLTERGVTVRTDGLERSETVGQVTPELLTSGEWEDVEFAEYNVEADAEQVKGGRVHILRQTADRVKDVLVGMGFQEMEGPHVDADFWINDCLFMPQDHPARTHWDRFALEEPTHIDELPEGLVERVERAHREGVGDDGEGYHSPWDEDFARALALRGHTTSLSTRYLSGEQIGEIEPPARFFSVEKVYRNDTLDPTHLLEFFQIEGWVMAEDLSVRDLMGTFEEFYARFGITDIEFKPHYNPYTEPSFELFGTHPTTGELVEIGNSGIFREEMLEPLGVECDVMAWGLALERLLMLMYGFEDIRDIHGTLCDLELLRETEVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA08</accession>
    <name>A0A3N6PA08_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_02835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93155">
        <property type="protein sequence ID" value="RQG93155"/>
        <property type="gene ID" value="EA462_02835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="732" mass="82700" checksum="196D9B1283220EA2" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHE0</accession>
    <name>A0A3N6LHE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_17310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86110">
        <property type="protein sequence ID" value="RQG86110"/>
        <property type="gene ID" value="EA462_17310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008231">
        <property type="entry name" value="CsaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF37">
        <property type="entry name" value="PTHR11586:SF37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="109" mass="12077" checksum="53A6085FC35FB5F7" modified="2019-02-13" version="1">MVDNPFDDEIRVGEILRAESFEEANKPKMTKLWIDLGDEYGEIRSAGQLDHHYDPEELEGRRVLCATTLGSVRIAGFKSEALTVGVPDEDGYPVLVEPESDVPLGGLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHI7</accession>
    <name>A0A3N6LHI7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_17010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86170">
        <property type="protein sequence ID" value="RQG86170"/>
        <property type="gene ID" value="EA462_17010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="368" mass="43033" checksum="BF11502BCB596414" modified="2019-02-13" version="1">MVQCRYCEQTFEEESALREHLYEVHERDEFSRIDQKRVEQYVDEHGLDESDNEEEQSPDQSIQREQRTVDTSDGIYPADRWELSDVEALSTDEIVAKLTEHGIETNETTFRNRVEDLDSATTLSEQWEAEYEVDATGYDQDFIWMAAQELWERWAPETPNKERIYDFVQEGRDLREKGNRAEACDQWLTAWEDILAVIPDDSTTIEEADRTLPTFLSLEAFIRSFDNDLATVAEDDPTYHEHRLEFCRQVCEKFPDADEEFLLDFRHFVADSLAELDRTAASRAEFEALIEEYPEDSWAYKKLADNYWLDDPNELSIDELERTAELYRAALDVEGPLEGATMVADRLEEVERRLTDARASNERGAEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHU1</accession>
    <name>A0A3N6LHU1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86784">
        <property type="protein sequence ID" value="RQG86784"/>
        <property type="gene ID" value="EA462_16755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="563" mass="60332" checksum="090DDFAFF4AC48F7" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI44</accession>
    <name>A0A3N6LI44_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86954">
        <property type="protein sequence ID" value="RQG86954"/>
        <property type="gene ID" value="EA462_14955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="159" mass="17701" checksum="874B5347565F43D3" modified="2019-02-13" version="1">MTTHSTHGSVTAEPLVRLTERGISISVRRIETPRGERLEFDVEDTDTAIRLDAIALECLTWQSEDSFLESVPVEARTAPSDDCVVERGQPAGSRTELTRITNEFCQIRVSRLVTDEREWLEIEAPKLGAAIALNAGAVRSVTHLDQRAFTALLSDRLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LID3</accession>
    <name>A0A3N6LID3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_14765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86919">
        <property type="protein sequence ID" value="RQG86919"/>
        <property type="gene ID" value="EA462_14765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="3"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="6">
        <location>
            <begin position="327"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="410" mass="45214" checksum="444566726319F52C" modified="2019-02-13" version="1">MTQYVIIGDGISGSSAAETLREEDPDSEITVITDEGEPLYNRILIKEHAKGKLPEAPISIHDETWYDEREIELSLNTHVTSIDPDAKIVHTHEGDDLSYDKLLVATGGTPTQLPVENSDADGIHHFWTFQDARAIRESAESAQDAVIVGAGLLGIDFAAVCGSQGVEGKYLMRGDRWWRYALSAGGAEIMHDGMRERGVEPIFDSGVDHFETDDGRVTAAVDPNGDRFECDFAGVAIGLTFNTEYLRGAGLEENNGIVVDEYMQTNVDDIYAAGDITRFHDVLLGEQAQNGSWGSAKEQGRVAAINMAADDESEVFEWVSSYSITHFDFPFLSFGHPTLGDEYAERRYSDTEWRRVAFKDGKIVGGVLIGDLSPQRTFKQLMREQRPVSDQAEVLLEQSVDLDELAPAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIE3</accession>
    <name>A0A3N6LIE3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L39e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl39e</name>
        <name evidence="7" type="ORF">EA462_15100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87124">
        <property type="protein sequence ID" value="RQG87124"/>
        <property type="gene ID" value="EA462_15100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_L39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020083">
        <property type="entry name" value="Ribosomal_L39_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_L39e_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="SSF48662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00051">
        <property type="entry name" value="RIBOSOMAL_L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="50" mass="6058" checksum="0F0B7A994C4E4CC1" modified="2019-02-13" version="1">MGKKSKGKKKRLAKLENQNSRVPVWVMMKTDMNVQRNPKRRNWRRSDTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIH1</accession>
    <name>A0A3N6LIH1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86989">
        <property type="protein sequence ID" value="RQG86989"/>
        <property type="gene ID" value="EA462_15190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="84" mass="8919" checksum="743552701282B03E" modified="2019-02-13" version="1">MNPRLKSALLWGAVGFMAFLVLVQGYALIVEPLVTIVHGTILAVAVAIATTASAYALEHRIAAWSARRAVDETETHGDDGKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIL0</accession>
    <name>A0A3N6LIL0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ISNCY family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87059">
        <property type="protein sequence ID" value="RQG87059"/>
        <property type="gene ID" value="EA462_15615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="321"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="576" mass="65244" checksum="B67F2D3335EE785E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIL5</accession>
    <name>A0A3N6LIL5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87069">
        <property type="protein sequence ID" value="RQG87069"/>
        <property type="gene ID" value="EA462_15670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018664">
        <property type="entry name" value="DUF2103_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09876">
        <property type="entry name" value="DUF2103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="249" mass="27216" checksum="A5BF252C0FB4ACFC" modified="2019-02-13" version="1">MECRHCGSPLEKPGDFCLVCRESNTGAIVLEAARDRATMTILARADGDDERPTDDTQIRGTTTITTTPERGENEPVELRNFAGLIGDEIRRKRPEEVYAGGVRSVIRAVRADIHYPCYRVDDEDPVAAVLERRGNRALDVVETPPAEKIGGSHTTLIGGRTGMRAIHAVADHPHVKKVIPGPIDAGGTGSRSGLRAKVTRADGGGNVRMLLRDGSSVQENRIVTTARDREMGERIRDDLNDVLSDEEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ23</accession>
    <name>A0A3N6LJ23_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0261 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87831">
        <property type="protein sequence ID" value="RQG87831"/>
        <property type="gene ID" value="EA462_13255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15488">
        <property type="entry name" value="Tm-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008322">
        <property type="entry name" value="UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044122">
        <property type="entry name" value="UPF0261_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06792">
        <property type="entry name" value="UPF0261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033271">
        <property type="entry name" value="UCP033271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0261" evidence="1">
        <location>
            <begin position="2"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="405" mass="42832" checksum="A2E038490F9900F5" modified="2019-02-13" version="1">MTVVIVGTVDTKGEEIGFARDVLEAEGVEVHVVDTGVMGEPSFEPDTSADAVARAADTTLESLREDADRGRSMGAMSEGAAAVVERLHETGDLDGVLGLGGSGNTSIATTAMRALPVGVPKLMVSTMASGDVEPYVGAKDVTLMYSVADIEGLNRLSQRVIANAALAMVGMVTNEPDVEISDAPTIGMTMFGVTTPCVQTAREYLEEQGYETIVFHATGTGGTAMENLIRQGVIDGVLDVTTTEWADEFVGGVLNAGPDRLDAAAETGTPQVVSTGALDMVNFGPRESVPDEFEGREFHIHNPQVTLMRTTPEENAEIGEIIAEKLSAATGPTALFLPLEGVSMIDVEGEDFHDPEADAALFDALRTGLGENVERIELETDVNDDEFALAMAKKLDEYMRETGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJV5</accession>
    <name>A0A3N6LJV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86214">
        <property type="protein sequence ID" value="RQG86214"/>
        <property type="gene ID" value="EA462_17130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="238" mass="24854" checksum="EE36FBD8FAF37478" modified="2019-02-13" version="1">MTVVFLPDLLATLVTGWTAEGGAELGIHRLHVMGIATVVGVFLLGLFAQAIRPKQRVASMWGAFVIILAVTAGTVGYGVGRPEEVIPFLIVTTVALVAHPAGRQLFRRSDSYSPALLALVAVAAVPLLAFVATQLSLSSSPVDPHALDGHYVMMAGLAIAPLAYGVFAATGFVGWRLAAWLAALPMAYYGLLAISFPAQSGAAGPGWAVAAILWAIAFVAVAEYSRTGSSTLLRRDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK73</accession>
    <name>A0A3N6LK73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88978">
        <property type="protein sequence ID" value="RQG88978"/>
        <property type="gene ID" value="EA462_11350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="324" mass="34003" checksum="4BE0A49CCDE51A1A" modified="2019-02-13" version="1">MDYYAGVDLGATNVRAVVATDDGTTIGEGHSATPRGPTGIDVTEGVLETVRDACDGADITPDAIDAAGIGSIGPLDLAEGAVIDPANLPDSIDRIPLTGPVEKLIGSDEVYLHNDTNAGVIGERFHARRNPDDMVYLTISSGIGAGVCCDGHIVDGWDGNAGEVGHCIVDPQGRVTCGCGRDGHWEAYCSGNGIPEYTRLLAEDDPTISTQLPLEDPDFAAKDVFELAGGDELADYTIEQLTHWNAIGVANVIHSYAPIVVSFGGAVALYNEALVVDPIRERISEMIMANVPEIRVTDLGDDVVLEGALASALTRGTGDRRHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKM7</accession>
    <name>A0A3N6LKM7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF354 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89218">
        <property type="protein sequence ID" value="RQG89218"/>
        <property type="gene ID" value="EA462_12700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007152">
        <property type="entry name" value="DUF354"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39662">
        <property type="entry name" value="PTHR39662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04007">
        <property type="entry name" value="DUF354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005357">
        <property type="entry name" value="UCP005357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="340" mass="38524" checksum="B00AEC28A6C589C7" modified="2019-02-13" version="1">MKIVVTIQHPAHVHFFKNAVRQLSEHHQVTVFVREKDVATELLEGYGIPYETLAGPTNSFLELAYTQLIYESRLLRRAREIEPDVMAAIAEPGVAHVATVVGSTGLIFTDTEHATLQNKLAFPFCDAVYTPTCYRNEIGEKQIRYSGYHELAYLHPDRFEPNPDVLADIDAREDESLVVMRLVSWDAAHDVGNSGFDRTQEVVSRLERTGARVLLTSESPLPNSLEQHRIDISPCQIHDLMYYSELFVGESPTMATESAVLGTPAIYASSIELGYVTELSEQYGLIFEYNGADRQSKSIEKALEILRNTSAQTWERKRERLLSEKVDTTEYMIQEITKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKR7</accession>
    <name>A0A3N6LKR7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotate dehydrogenase (quinone)</fullName>
            <ecNumber evidence="5">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_15715</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-dihydroorotate + a quinone = a quinol + orotate</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87078">
        <property type="protein sequence ID" value="RQG87078"/>
        <property type="gene ID" value="EA462_15715"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="11">
        <location>
            <begin position="51"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG87078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="356" mass="39162" checksum="726F696F0696CC40" modified="2019-02-13" version="1">MTLYSRVRPLAFKLPPERAHNLGKRTLKAAQSTMPTRATLSYIYQYEHPALEVDLFGTTFPNPVGMAAGFDKNAEVTHALEALGFGFVEIGTVTPYPQTGNDRPRLFRLREDRAMVNRMGFNGQGMDRVRDRLERNAVPKIPLGVNVGKMNTSSEDEAIEDYRRVFDRLSPFADYVVVNVSCPNTPKQFDETSSDHLRRIFETLQDENDEDRPILVKVGPDSPTKSVLELVDIVLEFDIDGIVATNTTTGRDGATDSNREEWGGMSGKPLADPSTEVIRSIAAATDGELPIVGVGGVDSAERAYEKIRAGASLVQLYTGFVYEGPSTATRINKELVELLERDGFSSIQAAVGADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LL67</accession>
    <name>A0A3N6LL67_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87800">
        <property type="protein sequence ID" value="RQG87800"/>
        <property type="gene ID" value="EA462_13080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="221" mass="23990" checksum="E5CD747160D243AA" modified="2019-02-13" version="1">MGTIRNNPVYRILDKIRSSAALTITFWGGVMTLIAFVIGDGVWAGIAGIWGLSLLVFGACWYVAAIRYVKPDRPEETNGDATEGGIDWGRVGTVVGASSIFGVYMAYVTSGIGLELVVLPVAFVAAAAFLYRQSTTLETLGYGMYVLGLSVFVTPLVFHFGAIPQSAYDAGIQIDHMLALGSILFMFTLIAFLLSLMGYFLNNRAQKKSDQQRLKSRMGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLV6</accession>
    <name>A0A3N6LLV6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5658 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90023">
        <property type="protein sequence ID" value="RQG90023"/>
        <property type="gene ID" value="EA462_08435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043717">
        <property type="entry name" value="DUF5658"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18902">
        <property type="entry name" value="DUF5658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5658" evidence="2">
        <location>
            <begin position="34"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="116" mass="12348" checksum="3E859F25F90719E4" modified="2019-02-13" version="1">MSSDGVYSHPRIPVTATPAELERLLWVFVALSLVGDIVTTFVGLHLGLAESNPVARGAIEGYGLVGMIVLKGLAVGVALFCRSLLPREYRPIVPAGLAVPWTVAVCINVYMISMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMH3</accession>
    <name>A0A3N6LMH3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate/phosphite/phosphonate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phnD</name>
        <name evidence="3" type="ORF">EA462_16500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86735">
        <property type="protein sequence ID" value="RQG86735"/>
        <property type="gene ID" value="EA462_16500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005770">
        <property type="entry name" value="PhnD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01098">
        <property type="entry name" value="3A0109s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="376" mass="41197" checksum="3F9E5BA566040EE3" modified="2019-02-13" version="1">MPVNNRRRNLLMGTGAAFMSGLAGCVGGDDDSGSGGNGDSTGNGTGNGGGTEFEDFDPDNPVFPQMAPTLLDEGFEVANINELDNFEERDEPRYGNPHPEPPESSDEWIDPDTIVMSLVPSEDPGVYEDLMDPIRENVEAETGKDTEFHGLTSYAAQVEAMRADRLHTCGFGTGAVPFAVNMAGAVPFAIQVAEDTFGYKLWVVTQANNDEINSLDDLEGKSVAHTDPASNSGNLAPRAWFTDEGVEPDEDYDVEYSGSHENSILGVQHGDYEAAPVASTVVERASREGAADADELKVVYNSVPFVTTGFTYKYNLHPDIREGIRNAYLEYDYMDTELAEYYDGRGRWVEIDYASHWDAVLSIQEYNEVEYVEDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMH8</accession>
    <name>A0A3N6LMH8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90313">
        <property type="protein sequence ID" value="RQG90313"/>
        <property type="gene ID" value="EA462_10070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="210" mass="23376" checksum="93F34A44FD54926C" modified="2019-02-13" version="1">MESTSGCMGGDRSGFAQTLDSLKRQGCNLLLVGSRTSKGHELVCRRLSALSSQEPRYRLLVTADSTTHRHGLTRPTETTTIEYATAESNPDGTALGNLGLEVIDAIDEFEAAADGLEPSELRVCVDSLVSLLQECETEAVFRLLHVVMSRTERARGMGHYHLPVSRDHDAVSLFEPMFDAVVELRTDDGVHEQRWHLRDREAPTDWIRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNS2</accession>
    <name>A0A3N6LNS2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87837">
        <property type="protein sequence ID" value="RQG87837"/>
        <property type="gene ID" value="EA462_13295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="172" mass="18677" checksum="E5D464C071701A02" modified="2019-02-13" version="1">MIDNTSDRPTQEITLTVNGNEITEEVEPRHKLSDFLRYRADSTDVRVGCEHGACGACTVEVDGKNVKSCMLFAVQADGSDVLTSTGLNEDDGLGPIQEAFHENHALQCGFCTSGFIMATKELLEKNPDPDREEIVDGLSDNICRCTGYVNIIKAVEDAADRMDTVSQATGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPF5</accession>
    <name>A0A3N6LPF5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91338">
        <property type="protein sequence ID" value="RQG91338"/>
        <property type="gene ID" value="EA462_05020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="PTHR12150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="289" mass="31178" checksum="A31C0C4185F3D224" modified="2019-02-13" version="1">MTVSVLVPSSLTREAEDKREATRKLGYVARAATVFRADRLLVYPDRGGETGRFDGGFVHTVLRYAATPPYLRNEVWGMRDELEYVGVLPPLRAASQTGSESNGSGSTRQGIVTEVGPDQRVRVNCGLQHPISLNVPSQMKVVEGERVTVRISSRRPVRAKLEDSPLPGLVVERTDLSTALGREDAGVCIAASRFGEELTVGRLETLAGRIERDGLTVAFGAPERGLPDIFGIEASTVSSSDEGTTDDGVEPTADPGFDLWLNTVPDQGSEVIRTEEALFASLAPLSLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPK8</accession>
    <name>A0A3N6LPK8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_05375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91403">
        <property type="protein sequence ID" value="RQG91403"/>
        <property type="gene ID" value="EA462_05375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="314"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="398"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="7">
        <location>
            <begin position="459"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="746"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="358"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="530"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="602"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="830"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="845" mass="90762" checksum="39BEE26C917D5DC0" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPP2</accession>
    <name>A0A3N6LPP2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable tRNA pseudouridine synthase D</fullName>
            <ecNumber evidence="4">5.4.99.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(13) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">truD</name>
        <name evidence="7" type="ORF">EA462_09105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(13) in tRNA = pseudouridine(13) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42540"/>
            <dbReference type="Rhea" id="RHEA-COMP:10105"/>
            <dbReference type="Rhea" id="RHEA-COMP:10106"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.27" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90137">
        <property type="protein sequence ID" value="RQG90137"/>
        <property type="gene ID" value="EA462_09105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01082">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="PTHR13326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="6">
        <location>
            <begin position="186"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="458" mass="50447" checksum="6282113E99935B14" modified="2019-02-13" version="1">MRPAHLTEQAVGMEYYVSDVDGVGGRLRDDDDHFRVRELERFSTEPVGASTDAYPHLVFRATLRGWDTNDFASRLSDALGISRERVNWAGTKDKYAVTTQLFSVYGTDPSALPSVDGADLEVLGRAGRRLEFGDLAGNGFEIVVSGPDHPENASQIGDELRDFGGFGGGSGPDSDGRDAGGSTPIGVPNFFGQQRFGSRRPVTHAVGLEIVRGDWEGAVMAYLGNPTDAEPDGTQDARTFVEETRDWKEALERFPNRLRYERSMLHELTECAGDPDEETFRAALERLPSNLQRLFVHAAQSYAFNLMVSERLERGLPFERPVAGDMVCFSDTDAPEGLELPDTDRSQRVDDRRVEAVTRHCERGRAFVTAPLVGTDTDLADGEQGEIERAVLADLDLDPADFDLPDEFHSSGTRRAILVRTGIDLERDPLSLSFSLPKGSYATVVLREFLKTDPVDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPV7</accession>
    <name>A0A3N6LPV7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90237">
        <property type="protein sequence ID" value="RQG90237"/>
        <property type="gene ID" value="EA462_09645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="211" mass="23170" checksum="F708BB1FE8185540" modified="2019-02-13" version="1">MSVRVGRQPEPELTFSDRELFDLALAWITLSVAFALLFAPIHRSAGTDLTFFATMVGMSFVTVGVAFLLHELAHKVVAIEYGQIAEFRADYKMLFLAVMSALIGFLFAAPGAVYHRGRITIKENAMIAVAGPVTNHLLALLFFPMMLFGGYIGLIGHMGVLINLFLAAFNMIPFGPLDGKTVLEWNTPVFVLVFGLSLLVLGGFVFLFGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ84</accession>
    <name>A0A3N6LQ84_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91733">
        <property type="protein sequence ID" value="RQG91733"/>
        <property type="gene ID" value="EA462_06695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="370" mass="39345" checksum="918BF505C13B0240" modified="2019-02-13" version="1">MIYPIVLPYLQGTYGLSLSVAGLLVTVLWLFGSIGQLPGGMLADRYNERTLMAASTIVVAVALGFVVTASTPVVLFLATALWGLGHSLYPIARITFLSNLYSERLGSALGVTMATGDIGQTVLPPIAAVLAVAIAWQVGLGFVAPLLLLVGITMYFTVPVRTSTESERDPQSMRETLAIFGELRNPEMGFMTVILFLYIFIWQSFTAFYPTYLTNVKELSPAIASVLFGFFFAVGVVVKPVAGGAYDRIGMRGSLISILLPPVLGFSLLPFVDNVWLLVGLTACISTMLGSGAVTQSYLADSFSEEMKGTGLGVVRTTTATLGAGGPLLFGVIADYGYFDEGYIVLAVIMAVVILLTVRMPGGRETASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRS3</accession>
    <name>A0A3N6LRS3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoadenosine phosphosulfate reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89874">
        <property type="protein sequence ID" value="RQG89874"/>
        <property type="gene ID" value="EA462_07620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="2">
        <location>
            <begin position="48"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="323" mass="37182" checksum="75AC181E75272753" modified="2019-02-13" version="1">MPPNFPEYVDVDYDDGDGEDPADYPHVNDRIEKAIEVTRQGLEQYENPAVMWTGGKDSTLVLYFVKEVAEQYDLEVPPAIFIDHYQHFEAIHDFVDHWADEWDLEVIYARNDDIGTYVEENGLEPGDDVPVSELSEHNRHHVENILEYEEDAFPFLLDTYAGNHLLKTVALNDALEEYDVDGVISGVRWDEQEARADETFFSPRHDPDIYPPHDRVQPILQFDEAAVWEAFWNFVVPDTVAEFPDDGYVPQSDDDLPNDLTQDDIPVSPKYFAGFRSLGSEISTEKSDEDPAWLQDLEGTTERAGRAQDKEDLMERLRDLGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRU0</accession>
    <name>A0A3N6LRU0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89904">
        <property type="protein sequence ID" value="RQG89904"/>
        <property type="gene ID" value="EA462_07790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_12" evidence="2">
        <location>
            <begin position="166"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="521" mass="57221" checksum="2102DB401F324F48" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS39</accession>
    <name>A0A3N6LS39_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92678">
        <property type="protein sequence ID" value="RQG92678"/>
        <property type="gene ID" value="EA462_00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="211" mass="24302" checksum="2996D37B3EE35FD3" modified="2019-02-13" version="1">MSDAEEKVTSKDTEEVIMEATFRAISKHGYADLRMRDIGEEMEMTRQVIHYHFDGKYDLLSSFLEHIIGQYEGSVDVDDDADPRSELAARIDQCLFGPEFDEFGHWDRMKVFHELYSHAQNDEQHRAIFNSHYEGMRDSIVTVVEAGMEEGTFRTVDAERMGQLITDVIHAARARKISLGHGDAPEEARSAIDEFILDSLYVDDERQLHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSC9</accession>
    <name>A0A3N6LSC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_00905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92818">
        <property type="protein sequence ID" value="RQG92818"/>
        <property type="gene ID" value="EA462_00905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="9"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="351"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="653" mass="75020" checksum="7E5E8CC7F6FF2C7A" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSI2</accession>
    <name>A0A3N6LSI2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_05690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91457">
        <property type="protein sequence ID" value="RQG91457"/>
        <property type="gene ID" value="EA462_05690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="73"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="274" mass="30433" checksum="04F319F6EFB0AC6B" modified="2019-02-13" version="1">MTDFGLKVRMAIVGSILFAFYMFVGAFALAMFGFGAWPLVLLGLLVLPVIQYKIGTWSATRRAESMPEEGQYRDIHQMTESLSRDMGIKKPELMVMEMGVPNAFATGRKGKGVVVVSTELIRLLERDELEGVVAHELAHIKNRDVVTMVIGQSIGMMVGWVAYMIYIMGNDRNFGSIIVGLVISNIAQMLVMVFVLAISRYREYIADEDARQYIGSGDPLARALEKISRGSEGRESSLDDSVSALCIFNADKSLLAKLFATHPPTEKRIQKLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSQ9</accession>
    <name>A0A3N6LSQ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquinone biosynthesis protein UbiA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_08510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90364">
        <property type="protein sequence ID" value="RQG90364"/>
        <property type="gene ID" value="EA462_08510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="286" mass="29990" checksum="8FF40349C9C7C572" modified="2019-02-13" version="1">MSLVRHGSGLEANVRAFWSQVHPVFMLPPLAASLFGALLATTIDPTLAAVHVTAMFAAVYTAHVKDGYVDFHVRDEDDDHPLTVGGCRIGIAASTTIFVGCCLLLVVLANPLAVGLTVPTWLIAFFHAPQLDTNPLTATTGYPIGIALAILGGYATQTGTLSAVVVGFALVFLFLLSGIKVIDDAQDYEYDRSIAKRTVAVVVGPRRAYSIAYGLILTALFGVAALAVVRVFPPGAVLAALAFAAVAVVARQADPEIATMLLIRGSYVFLAVLVAAVWFEPLAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSV9</accession>
    <name>A0A3N6LSV9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93078">
        <property type="protein sequence ID" value="RQG93078"/>
        <property type="gene ID" value="EA462_02410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="348" mass="40518" checksum="31EB071279D3425F" modified="2019-02-13" version="1">MSFSEEATVVAHQNSPLPRYTESGPDREIDWVIADRDKLVGYESKYGDSLSSSQLQDELEKLELNAEGRDFVLITVTPHTTPPRIIGRFENDPVHWISWFSISRRLHQIKEAEIQSEQRPILRMLQDLFEAEDMHPFTGFDHHDKLQYRYFIRDLRQELVQTELENPGKVNTSSTKDPEPSSWKRLVPKRLDVPFVRESREDTWKRSRSYLTATVDTETHGVHAGIVFNLREIKSHRNYVANSLEDLIEYAADRDLQLWASMNSLNQWKVGVPRTDDPAEMRSWLEDGNKNAVRVNGTNFKKAIFVNECSASKPSAIVQKAKKELLRQYEDFLVSDELYPWSTLEEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSW4</accession>
    <name>A0A3N6LSW4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nif3-like dinuclear metal center hexameric protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93073">
        <property type="protein sequence ID" value="RQG93073"/>
        <property type="gene ID" value="EA462_02380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="27243" checksum="E0F972AA09870611" modified="2019-02-13" version="1">MELSTFVDRLDETLCHDDYAELDASANGLQIGPAEGTVEHVAFAVDGVLETFERAADVGADALVTHHGISWGGFDRVTDGTYDRVAALIESDLALYVSHLPLDGHQRLGNAAGVADVLELENRAPFGELGPEHIGQRGRAPAPYAPTALRDRLESELDTGDQPVRLLEFGPEEVEDVAVVTGSGTDWLAEAADVGADALVTGEGKQQVFHEAREAGITVVLAGHYATETFGVRSLQRLVEEWGLETTFLDVPTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT13</accession>
    <name>A0A3N6LT13_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS200/IS605 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tnpA</name>
        <name evidence="2" type="ORF">EA462_03510</name>
        <name evidence="3" type="ORF">EA462_06965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91680">
        <property type="protein sequence ID" value="RQG91680"/>
        <property type="gene ID" value="EA462_03510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91737">
        <property type="protein sequence ID" value="RQG91737"/>
        <property type="gene ID" value="EA462_06965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="132" mass="15500" checksum="A34F39C4AB8704A3" modified="2019-02-13" version="1">MESYKSHAHSISLCKYHFVWCPKYRHEVLELVQDELAELFQGTAERFGHEIVSREIATDHVHLFVEADPKWSPAEIAKQFKGYSGRTILKRHPEIKQRYFWGSGLWKDGYYVGTTGAVSEDVVRRYIEETEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT54</accession>
    <name>A0A3N6LT54_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93208">
        <property type="protein sequence ID" value="RQG93208"/>
        <property type="gene ID" value="EA462_03160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="240" mass="25476" checksum="382CF3B20E0CAA70" modified="2019-02-13" version="1">MSDFDKEAEREKLREKYERDKQEREATQRMSDLLLKGATMTNTHCGTCGDPLFQQEGTTFCPSCHGNADAVEGTNLDGQPTDEPSAGGNSGGSAGSGSEDVNTSPARRAADEPPTARRTGDQAPAVRSADGEPTTQPAGETAETTTPRGGEDPKYERRSTGGSESHDRGGASHPSSDETASRGSSLSQSVAEGDCETARDSLVRALERFSREAADTDDPRYAKECLEAAREASETLNALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LTD9</accession>
    <name>A0A3N6LTD9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93303">
        <property type="protein sequence ID" value="RQG93303"/>
        <property type="gene ID" value="EA462_01925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="221" mass="25016" checksum="EEADFF8AF17BAEE8" modified="2019-02-13" version="1">MVSEYDFWLLDLDGTLVDVEWSYTRDVFDRVGSRLGREFTDQEADILWNGLTGSRDRQLEEWEIDPATFWAAFHDEEEPLVRAERTYLHDDAAFVADLEVPVGLVTHCQEFLCEPVLDHLDIRDWFDVRLCCTEETGWKPDPGPVERVMNDLEVAGNGHRGVLAGDGANDVGAAWNAGLDAIHVERVGHERRGQCVLGDYRVRSFDDLSLPTPPTAAQSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVK9</accession>
    <name>A0A3N6LVK9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yciH</name>
        <name evidence="7" type="ORF">EA462_00730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92787">
        <property type="protein sequence ID" value="RQG92787"/>
        <property type="gene ID" value="EA462_00730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00604">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022851">
        <property type="entry name" value="SUI1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01158">
        <property type="entry name" value="SUI1_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="97" mass="10722" checksum="5BB8C5BC578B7E8F" modified="2019-02-13" version="1">MSEVCSTCGLPEELCVCEDVAKGQQQLTIRIDERRYGKEVTIVEGFDPKDVDLDSLSSDLKSKFACGGTVEDGHIELQGNHTGRIEDFLRDRGFNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVS5</accession>
    <name>A0A3N6LVS5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">RNA 3'-terminal phosphate cyclase</fullName>
            <shortName evidence="5">RNA cyclase</shortName>
            <shortName evidence="5">RNA-3'-phosphate cyclase</shortName>
            <ecNumber evidence="5">6.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rtcA</name>
        <name evidence="9" type="ORF">EA462_01240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92877">
        <property type="protein sequence ID" value="RQG92877"/>
        <property type="gene ID" value="EA462_01240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00200">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="PTHR11096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="PTHR11096:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="SSF52913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RTC" evidence="7">
        <location>
            <begin position="12"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="RTC_insert" evidence="8">
        <location>
            <begin position="204"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="5">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="323"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG92877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="380" mass="40080" checksum="CB708769B8596C3B" modified="2019-02-13" version="1">MTPVHRLDGSNAGGQFLRTALGLSVVRNESIRIENVRGDRSTPGLRHQHLAVLETIAEICDADVSGDGVGSETIEFDPDLPTNGRRGGRSDRSSPRRTDRRGSLDGGDYAVDIGTAGSITLLFDALVPLASVLESPLSVTVSGGTDVKWSPPIDYTRYVKLPLLRTFGLSVACEVDRRGFYPDGGGRATLHLGPSRFDRIELLERGPLEGIRLYSTEAATLSDRDVAHRQAEGALERLESNLGAAVDADRDGDGSVLEPIERRETTAGSDCPGTAIVLRLDYATGAVGFGALGERGTPAERVGELAADAALRHLTGAAPVDRHLADQLLVVLAIAGGRIRIPSGTDHVKASCDLLEAVGGAVEREQDGRGTVVSVTPLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWJ9</accession>
    <name>A0A3N6LWJ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_03265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93227">
        <property type="protein sequence ID" value="RQG93227"/>
        <property type="gene ID" value="EA462_03265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="340"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="540" mass="58439" checksum="C5C4F0CD85A4F85D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXH0</accession>
    <name>A0A3N6LXH0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86751">
        <property type="protein sequence ID" value="RQG86751"/>
        <property type="gene ID" value="EA462_16585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42200">
        <property type="entry name" value="PTHR42200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Arch_flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="162" mass="16902" checksum="D2065EF7F8A1F552" modified="2019-02-13" version="1">MASVSAAHMIMFIGSLVLASAVAGTVIMEVGQVSDSIETRGTSVADEIETEIAIISDASRSDAIVDDDDVQTLTVLVKNIGNAELEADSSTVDILVDSSYVSSADVTVERVDVDSTVWEPGGVVAIEIADQNVDGDTAVTVIASGNEDTIRFYWDAEDGADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXJ0</accession>
    <name>A0A3N6LXJ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation protein SMC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86781">
        <property type="protein sequence ID" value="RQG86781"/>
        <property type="gene ID" value="EA462_16740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="642" mass="73744" checksum="280A184615BE7986" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ12</accession>
    <name>A0A3N6LZ12_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87953">
        <property type="protein sequence ID" value="RQG87953"/>
        <property type="gene ID" value="EA462_13910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="28167" checksum="FB7EDC2DA04AFC69" modified="2019-02-13" version="1">MSDVQYSVDDGVAELVLDRPDARNAMNESVIDALVDYVEEAAVDDDVRVLVLRATGDVFCGGGDVKKLGTLLDDDVTPIERLDYITQGIHRPIRALVDLEKPVVCRLQGDAIGAGANLALACDMIVATEDARLIEGFKNVGLSIDCGGSYLLPQNTSLCVAKELVMTGRPVDGTEAEELGLVNYAVPESELDDTLSDLVDRLRDGPTRAHGLSKQLLHEGVNATFDEALENEARANAILGASEDHAEGIAAFREKRSAEFSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZD9</accession>
    <name>A0A3N6LZD9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93284">
        <property type="protein sequence ID" value="RQG93284"/>
        <property type="gene ID" value="EA462_00935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="98" mass="10903" checksum="8BEA651E6F0C956A" modified="2019-02-13" version="1">MIELVAESDNDLSVRTLAREIAAREQDVPMDCATGEPYRNVYNALSQTHLSTLSDTDVIIYDPERQTVAPGPNLTITLLLSNLNQAAFQTLWNPEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZT5</accession>
    <name>A0A3N6LZT5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88820">
        <property type="protein sequence ID" value="RQG88820"/>
        <property type="gene ID" value="EA462_10475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="182" mass="20108" checksum="8A9B96375710A931" modified="2019-02-13" version="1">MSRDSLVWETLDRGVAYSCPGFDVVNESVRLPDGTETEFDYLSEPESVCIVPFTPDGDVVCIEEWRQAVDRVNRGLPVGGTEPEDDDLEAAARRELAEETGHEADRLEALVTVEPANGTADSRTHFFVARDCRPTTEQQLDHNESIRVTTIGLEELTDAIGTGDIADGRTVLAISYYRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0D9</accession>
    <name>A0A3N6M0D9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89080">
        <property type="protein sequence ID" value="RQG89080"/>
        <property type="gene ID" value="EA462_11930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043941">
        <property type="entry name" value="EMC6-arch"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19094">
        <property type="entry name" value="EMC6_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="107" mass="11711" checksum="2DA5437DC4587AF9" modified="2019-02-13" version="1">MSTESISDRREHIRSISVTAFSALLGVGAALASASLTGDLTPAEAATETTPLFLVLGAILVQFVLFDFTSIYGDDEFGIKHYLFITFMTFSFWFVVWGILLTAEYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0G0</accession>
    <name>A0A3N6M0G0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MinD/ParA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_12110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89110">
        <property type="protein sequence ID" value="RQG89110"/>
        <property type="gene ID" value="EA462_12110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010224">
        <property type="entry name" value="MinD_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01969">
        <property type="entry name" value="minD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="4">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="292" mass="30218" checksum="83DCE1CB3BC280EA" modified="2019-02-13" version="1">MSHETVYAIASGKGGVGKTTTTVNLGTALAQAGERVAIVDTDLGMANLAGFVSLTPDATTLHDVLAGDVSIDDATYRLADNIVAVPSGTDLDEYAETSPEGLREAVSELRATYDYVFLDVGAGISHETVLPLGLADAVVVVSTPEPAAVQDSKKTVELTDRAGGDLAGLIVTRTHPGSDISYEEVASRLEIPLLGTVPEDPTSRESVYAGTPLVVYDPDSDASAAYRQLAADLAGIEIPDHSSGGDDSVGTVSSDDDSNPDVDSDRDHEEVIEGETAHDEVSSAITEAESDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0K1</accession>
    <name>A0A3N6M0K1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89160">
        <property type="protein sequence ID" value="RQG89160"/>
        <property type="gene ID" value="EA462_12395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="9209" checksum="EF97F72BA5D6404F" modified="2019-02-13" version="1">MSVLSTEDEGKFLMDVRGEQIGIVTEIDPIEQVAYVDPEPTLTNAWIQSLGRGGAGEDDIEIPSENIETITDSEVRVDADLSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2B0</accession>
    <name>A0A3N6M2B0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type 1 glutamine amidotransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89940">
        <property type="protein sequence ID" value="RQG89940"/>
        <property type="gene ID" value="EA462_07985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="225" mass="24307" checksum="70ECDDC0FAC32E51" modified="2019-02-13" version="1">MTEALFVVSENGYWGEECTEPLETLSEAGVEITVATPSGGPPQIDEQSIDPDQVGEETASHVLDVHESDDRLNDPIPTARADAELYDAVVYPGGHGTEWDVNQDSDARRLLRETIEGDGTALVVCHAVGILAFARDSHGAFIVTGRDVTGFPNEWEEDTVDEDGRLPDGRKLPYWVEDEVIAAGGNWDAELESEASVTVDGDLITARGPESSTAAAETLREKLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2P5</accession>
    <name>A0A3N6M2P5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90090">
        <property type="protein sequence ID" value="RQG90090"/>
        <property type="gene ID" value="EA462_08815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="229" mass="25039" checksum="6AF2253F9C57897B" modified="2019-02-13" version="1">MDVLSDDIVRFISAIGPEPDATLREMGEYARSEGFPFVGPEVGGFLRFVARVSDARRVFEFGSGFGYSAYWLAGAVPEDGEIVLTEVDDDELELARAHLADGGYDDRARYELGDAMDTIERYDGPFDVVLIDHQKHRYADAFEAVRPKVPVGGVVVADNAITAGPIEFETLLEILEAEGSADGDPDPIQRANEYTRGIADYLGRVIDDPAFETIVLPLGEGIAVSYRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5G5</accession>
    <name>A0A3N6M5G5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trxA</name>
        <name evidence="4" type="ORF">EA462_14015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87969">
        <property type="protein sequence ID" value="RQG87969"/>
        <property type="gene ID" value="EA462_14015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG87969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="119" mass="12670" checksum="B187DE5B130D297C" modified="2019-02-13" version="1">MTTDAHSGSPGQSTDRPVHVEGEDHLEELIADNDVVLVDFFATWCGPCQMLEPVLDGLAGETDALIAKVDVDDHQQLAGAYGVRGVPTLALFAGGEQVEQHTGALPADRLRSLIEGYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M653</accession>
    <name>A0A3N6M653_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91520">
        <property type="protein sequence ID" value="RQG91520"/>
        <property type="gene ID" value="EA462_06040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="182"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="395"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="720" mass="77943" checksum="3791A80F980DFBED" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6H0</accession>
    <name>A0A3N6M6H0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88906">
        <property type="protein sequence ID" value="RQG88906"/>
        <property type="gene ID" value="EA462_10960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="288" mass="32407" checksum="EE54B03F4D15D79F" modified="2019-02-13" version="1">MTVLDQDTRKGIYSLLKKKTSVEDVNEIRRLSYEWKNGSFCDEGQTLERIYDSFLDIDRPLRGNGGELAGRPSRGNEDTVLEVMYRLSSHYINSHNGVSEVYRGVNTYDGMIEAVLDALNPERNSTNLDLTKLSNFTLDRGTADYHGLVVVRVDLEPKQAAIAADFFLPYSETDHTEIPAADEISKNEGEIRLIGDTVPDITTSKITVKDGRKPISLLFDPANQNTIEEHDYAAGIIKKVADENEVIPDAAIDAVESWFFNYFQKDPNKALNIKAQVEQVLDRSIHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6X2</accession>
    <name>A0A3N6M6X2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89086">
        <property type="protein sequence ID" value="RQG89086"/>
        <property type="gene ID" value="EA462_11960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="80" mass="8647" checksum="37076C3408C56B1E" modified="2019-02-13" version="1">MEQLASMSVIEALASAEETDPTALEPTLYESIDPDALDALVQSATRSMTLEFTHGDYLVRIDESASVTVTPTDDRLAETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M723</accession>
    <name>A0A3N6M723_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GFO_IDH_MocA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91131">
        <property type="protein sequence ID" value="RQG91131"/>
        <property type="gene ID" value="EA462_03805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="102" mass="11831" checksum="B92FCC7245FDCD56" modified="2019-02-13" version="1">MDSRAIVPFRCGSYNAHDSREGIYVATPNAFHKNCAIAAAERGKHVICEKPPEWRPVRRRRRTRHVPTRVPDRDDRVVHGSTLVRVTDRVREPFRNQSGCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M786</accession>
    <name>A0A3N6M786_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91201">
        <property type="protein sequence ID" value="RQG91201"/>
        <property type="gene ID" value="EA462_04215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="444" mass="47379" checksum="88570F430E316719" modified="2019-02-13" version="1">MVFRGREKVATVMHSRRTLLRTGCAVGLLSVAGCAAPRAGLTGHRRNAGVPDPADPSYREWLPAAEETDAIDQDVPIRYVDVERALERGNTLSRGVAGSLFEFWAVGDWFGHELAALDGILVRSDSPLTVIYAGDISRPDARDELEESGYEHLEGDAPWSVFVRWDQPRLIGVSEAGVVQTSIDAAVDEPLDGALERVGTFLETKAGNRTRRHESDDVFERLTDRLGAGIRTTVPLTPPPWLPDGGRWGTAIDGTDDGSVRRATAVVPANGDASPGETADARETDGGSIEDDLAEHIGEAWSGDPSVYTASSTVEGSVRRAPDEAPTSIDELVPPRVTIEFEYDDDESAGIVSHRTGTPLETDRLTVAVDGQTGESLALSGETFEAGDRFAIRGLPATALVSLGYDLTDVTAVTIASFVGPGQPADGEEPESEPEPEPDPLDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7A4</accession>
    <name>A0A3N6M7A4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89236">
        <property type="protein sequence ID" value="RQG89236"/>
        <property type="gene ID" value="EA462_12795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="191" mass="19695" checksum="FCA223308915F924" modified="2019-02-13" version="1">MSLEPEPTGRENASVRSVPEVIALVIGIGGLWFAVGPVGGVIGGGTAVLWYAFGVPYALAAGFVGLTAVTAGGSTAELGTVRVPVLAYGLLVLAAGYRTPTPLRFGRTVSGTVAGLAGVGWLAVTFAPDSLWIAGVATLVFGITVSSVVHRYERFRLGLTATLEDHNGETDATDRDSNGFRTASDRESDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M846</accession>
    <name>A0A3N6M846_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91521">
        <property type="protein sequence ID" value="RQG91521"/>
        <property type="gene ID" value="EA462_06045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="190"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="377" mass="42441" checksum="750FF00E03CA2F58" modified="2019-02-13" version="1">MKIGINGLAAKMGGGVTYLQHLVTNILEVSDHRLHFFVSSVAVERFNLPIESDQLTVESVDTSGTASRLWYEQTYIPRQIVRENIDLLYSPSEIPLLMCPCKQVVANQNSHLYYDIDTEESFRQQVRKRVLARALEVSQSISESMIFVTESSKRKAARELAISEDNAYAIHHGVDPSFGDASNEGLITPAEERDYILMVSTLYKHKNVHNLILAYSRLPAETRHKHPLIIIGDKTTDKEYTQRIESMAKELEVAEDVSLVGRVPLSEVKSYYSNAHLFVFPSLIESFGLPLLEAMTAEVPAVASASASLPEVGGDAVLYFDPKDPDQISVIIEQVLNDEKLREDLIVRGRNRVKEFTWEKCAEETIEIFEKAVDPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M859</accession>
    <name>A0A3N6M859_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91541">
        <property type="protein sequence ID" value="RQG91541"/>
        <property type="gene ID" value="EA462_06165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="99" mass="10746" checksum="EC21414216F8BCA7" modified="2019-02-13" version="1">MTDPSTVRERQASEEGGQATDADSPSRAERDPAHGALERTVPNLAGAIRKTGFWTAIVVPFLYVPILLNGLTTWIESTTFLVLLGINLLALYVGHTHCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9I2</accession>
    <name>A0A3N6M9I2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90186">
        <property type="protein sequence ID" value="RQG90186"/>
        <property type="gene ID" value="EA462_09360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="171"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="336" mass="38665" checksum="9E228510AFEC4E4A" modified="2019-02-13" version="1">MSIDVRLATDDDRERWNEYVRRSPQGTLCHELEALRVQAEYADATLHPLIGFKGQEVVGLFPLFEVKKRFVTTVFSPPPHLRVPYLGPAFLNLEKLKQRKRERRRQRFMDGCFEWISSELNPKYGHVRTSTGFEDARPFIWDGYDATPEYTYAVDLSISEDELLMTFSSDARSNIRNTDEDRYEIGVGGPEEIRLIHEQVRNRYESQGIGFDVPLEFVLDLADRSENGHVRPYTLRVDGEFVGGILALEYRGTTSRWMGGVRTDADVDVPTNDLLDWAIMEDGLESGLETYDLVGADTRRINRYKAKFDPALRTYYSLEYGSLGMRTIASLYDSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9Z8</accession>
    <name>A0A3N6M9Z8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93140">
        <property type="protein sequence ID" value="RQG93140"/>
        <property type="gene ID" value="EA462_02755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="46" mass="5093" checksum="F8C3A1FAC5956EFF" modified="2019-02-13" version="1">MISGEFDVMVEIEGDGPHDILTTVTSDIRSLEGVGTTRTYVRLDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MAC9</accession>
    <name>A0A3N6MAC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93290">
        <property type="protein sequence ID" value="RQG93290"/>
        <property type="gene ID" value="EA462_01525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="418" mass="45810" checksum="0A20F0826F8D8569" modified="2019-02-13" version="1">MTSAARSLSEPEVLAHAKRRLFPPDGTETDTEQSSYVVADTQFAKEEWLPGSPVDPDIRARLAPFNHVRIGGGYPDLVGVARLESDLLAVERLGEEPPLIAIEAKGYASGGVDTRRGIVQAYDRLHEANAAYVAAPADAVSGTDRTLARELNVGVLGVEPTGEVEVLDVPRVVGNRTTSEAAALRFQAGSQGVANASFGLNHPKNYLGYPLAHDADGDTATLLTEHRVVSAVDDARRGAAFLGLIEDGPFVELTPLGREVVRFGNARCGSAEAALSQFSEWYQSRRRFVDLAPAWGQLARRVLFSYPATELLVTEIQTMHDDWQPEPSLVELVEHAHELHPTFTVELFIRSDETVRRRVLTDDGSLRQSALEDGSVYHSPTVFQLKAMLYHAGILTERGREPHRLEPTEDVWALRQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBF3</accession>
    <name>A0A3N6MBF3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Death domain-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92791">
        <property type="protein sequence ID" value="RQG92791"/>
        <property type="gene ID" value="EA462_00750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043902">
        <property type="entry name" value="DUF5786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19099">
        <property type="entry name" value="DUF5786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5786" evidence="2">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="58" mass="6476" checksum="1B1FD1BC931F2588" modified="2019-02-13" version="1">MGFGSYDESEQQDVDADFDEDDAVKSDQNSHDGTLEFENGASSDELLDRLKEIKDDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBK6</accession>
    <name>A0A3N6MBK6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92851">
        <property type="protein sequence ID" value="RQG92851"/>
        <property type="gene ID" value="EA462_01100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="286"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="550" mass="61507" checksum="072B3FA10BC84321" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC36</accession>
    <name>A0A3N6MC36_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93051">
        <property type="protein sequence ID" value="RQG93051"/>
        <property type="gene ID" value="EA462_02235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="55" mass="6259" checksum="E6F4A69643EAC6F6" modified="2019-02-13" version="1">MHAFIEDHYDVTYYPAHLSRKLREAGMNYAQPRPMDHAAPTIQTRFSPSASPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCG6</accession>
    <name>A0A3N6MCG6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 1 glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93191">
        <property type="protein sequence ID" value="RQG93191"/>
        <property type="gene ID" value="EA462_03045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="248" mass="27521" checksum="02AF15C5383AE701" modified="2019-02-13" version="1">MSQLRIAVLDATHQDEHTRRNFRRELDGSLSEFDVTDGSLPDHFEFDGAVVTGSRSSVYWDEEWIESTKAWISAAIDRGMPCFGICWGHQLLADVLGGTVEDMGSYEVGYSDIERTDRDSTSRLLEGVSERFLAFTSHSDAVTELPPGATSLATNDYSNHGFRKGRVFGVQFHPEYDPVTARDLVHSKNLSDERLASVLDEITEENYRAAAQAKLVFENFLAFVRETTAGDVSVEANGDRPSATGRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCL0</accession>
    <name>A0A3N6MCL0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome C nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_03285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93231">
        <property type="protein sequence ID" value="RQG93231"/>
        <property type="gene ID" value="EA462_03285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019020">
        <property type="entry name" value="Cyt-c552/DMSO_Rdtase_haem-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09459">
        <property type="entry name" value="EB_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EB_dh" evidence="6">
        <location>
            <begin position="10"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG93231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="423" mass="49456" checksum="9A5C28BA8250CA91" modified="2019-02-13" version="1">MTDHWRPEQKLKRLDTQIAFNSEQIYFRFRWDQPNPGGWIHDMLVYRDGEWTQFANPSPWIAEGDNSEHTGFYEDRVSFLFDDGSVKGFEEFGGWLTVHTGMRSLPSEVSEQTVREHEHLGDDGLEKTDIRKYIPQAVEGEWWENDWRQIRSETELDQLKQDGVFLDLPMWRAHRSNPKGYGTDHHVLDYRHSDQGQNTYTTQEWDPVDGPEYMWDPDVVEGGALDYHEIQRGNFPDQQDGTYALVLENAVEFDPDVAEWEGAMIPRRPLREPYGSAADWRGAGTWDDGEWIVEMWRDLQTDHPTDTKQLERGGVYTWTPAVHHGAGKRWHWVAYPYKLGLGVRPDYRGEYHSHGTSELVAEAFDGERPDWSEVPTYTIPLIFPGILDWTDLTSDNHAMSEEIRNAEITMWELYEKDPESFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCL3</accession>
    <name>A0A3N6MCL3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Biotin synthase</fullName>
            <ecNumber evidence="3 12">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">bioB</name>
        <name evidence="16" type="ORF">EA462_05805</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="12 13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12 13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 12"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91476">
        <property type="protein sequence ID" value="RQG91476"/>
        <property type="gene ID" value="EA462_05805"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 12 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="50"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RQG91476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="346" mass="37563" checksum="FFCE2B58BFD943AC" modified="2019-02-13" version="1">MVYETGNETIDDALERVFAGERLDRTDGLALIAQPVEALAEAGSVVRDHFGDGTVDACSIVNAKAGNCAEDCGFCAQSVHFDTGIDTYEFLGPERVLEAAKRAERDGAQRFGIVLAEKGVSKDRRPDEWEEVLEAIRLVRDECDLEVDASLGILTREEADILADTGINHYNHNIETSPRYFPEIVDTHSFEDRVRTLEIATEAGMELCAGVILGMGETPTDRVHAAIALQEMGVSSLPVNVLNPIEGTPLADRNVEITTDEIVATVAVYKLLHPEARVRLTGGREVNLAPDEQHRPLEAGADGILIGDYLTTDGQSPAADLEVVDRAGLEPNRATNDFDPDAITDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCV7</accession>
    <name>A0A3N6MCV7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">EA462_06495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91596">
        <property type="protein sequence ID" value="RQG91596"/>
        <property type="gene ID" value="EA462_06495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="177" mass="20650" checksum="92E17032B55201E8" modified="2019-02-13" version="1">MVNLWEDLETGPNPPEEIYAVVECLKGERNKYEYDKDVPGVVLDRVLHSNVHYPSDYGFLPRSYYDDEDPFDVLVLVEDQTFPGCVIEARPVALMKMDDDGEQDDKVIAVPIEDPRYDHIEDLEDIPQQRRDEIDEFFSTYKNLEAGKEVETLGWEDKQAAYDAIEHAQDLYEEHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFM2</accession>
    <name>A0A3N6MFM2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="2">RPPK</shortName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="2">P-Rib-PP synthase</shortName>
            <shortName evidence="2">PRPP synthase</shortName>
            <shortName evidence="2">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">prs</name>
        <name evidence="6" type="ORF">EA462_00275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92706">
        <property type="protein sequence ID" value="RQG92706"/>
        <property type="gene ID" value="EA462_00275"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_A">
        <property type="entry name" value="RibP_PPkinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037514">
        <property type="entry name" value="Rib-P_diPkinase_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="155"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="284" mass="30000" checksum="DA79D4355FC2E0AF" modified="2019-02-13" version="1">MIISGSASQSLAARLATELEESLATAEYDRFPDGELLASVPDIDANAERAVIVASTVSSDAHLEVLQLQDAARQAGIDETVTVLPYMGYGRQDRSFDAGQPISARAVARAISTGTDRVLTVSPHEQVVCEFFEPTATAVEAADRLADPLPADLVDPVFLSPDAGAISLAETVRDAFGAGETDYFEKVRHSGTAVEVSLSGVDVVGRDVVITDDIIATGSTMSEAVAVLRERDVGRVFVTCVHPLLVRNAYTKLARAGVEAIYATDTIERESSVVSVAPELAAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFY9</accession>
    <name>A0A3N6MFY9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92836">
        <property type="protein sequence ID" value="RQG92836"/>
        <property type="gene ID" value="EA462_01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025159">
        <property type="entry name" value="AbiEi_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018547">
        <property type="entry name" value="AbiEi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09407">
        <property type="entry name" value="AbiEi_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13338">
        <property type="entry name" value="AbiEi_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AbiEi_1" evidence="2">
        <location>
            <begin position="92"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="277" mass="31344" checksum="0A8D080798138399" modified="2019-02-13" version="1">MSPTNEPEIQRKSLSTRESRTLSRLASEGRQIITIDDIEDTLDIPRKSAKDMAYSLKEKGWLERLTPGKYMILPLSAGEKAVYTEHEFVIASALVDPMYVGYWSAMNHHGLTEQLSRTVYLVTTERVQPREIHGVEYRPVSVTEQKFFGYQPSAVGSTQVNIASIEKTLVDCADHPEFCGGIGELVKAMQRATEKRCSWETVVEYLRQVGNGAATKRIVYLADQLDIDLPEYRDLVENFTTGYPLLDPTREATGTRDSKYQLRLNVEPEAFLPDDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MQU1</accession>
    <name>A0A3N6MQU1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_17115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86189">
        <property type="protein sequence ID" value="RQG86189"/>
        <property type="gene ID" value="EA462_17115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="27"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="274" mass="29249" checksum="3584AD9B9F509E60" modified="2019-02-13" version="1">MNADSEDPNADEQYHLEVSADDVAETVLLPGNPERLEKIVAHWDDHESRAHHREYRTATGTVEGTPISVTSTGIGSPSAAIAVEELARVGCKTFIRVGSCGALQPEMNVGDLVITTGAVRQEGTTAEYVREDYPAVADHEVVSALIAAAERLGYDYHTGLTMSADSFYAGQGRPGFDGFEAAGSSDLVDQLTEANVANIEMEASAICTLATLYGLRAGAVCTVYADRDGGEFRVEGESRAAETATLAVHLLAKMDERKREEGVDSWHAGLSLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MR20</accession>
    <name>A0A3N6MR20_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86683">
        <property type="protein sequence ID" value="RQG86683"/>
        <property type="gene ID" value="EA462_16200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="333" mass="38058" checksum="05F8036316A59F8F" modified="2019-02-13" version="1">MLEKGTSYFSVRDVDHAERDLDRFRENGLNAVLHTFSERDRQYYAESMSDIVAASHDRGFRVYMNPWSIGRVFGGEALSEFIGKNPESCQVLSTGDRVPTACFNDPGFNEYMRGWVADAADVGADVLFWDEPHWYIPDWFDHEVPEGAWTCRCESCQELYEQEYDEQMPATRTDRIDEFREASLLSFLDEMMELTAEKGLENAVCLLPSEDSDHGLSDWERLAANDHLDVLVTDPYWDVFDEESPAFISYFTDTVVSLAEEHDIGSQIWIQGFRLDDDPETVEDVRKATRAAIDGGVDSVFMWGYDACRSISDIACEDPEAVWNAYLDELPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MT48</accession>
    <name>A0A3N6MT48_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87955">
        <property type="protein sequence ID" value="RQG87955"/>
        <property type="gene ID" value="EA462_13920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="160" mass="18698" checksum="3975AFABA8618E2C" modified="2019-02-13" version="1">MNYEITFATEEDADDILDLWYEYSDQLSDIDDRYTHKDEAGEQWRNYFLNQMVNSSKAAILVADSEEADGLLGVIEVRIMGSHPIFQLTQHGMVFGHHVRDEYQGNGIEESLLEAAEQWFTDEKDLPFYRVNVLAQNDYLKDIYDEYGLEQIEYTYEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MU93</accession>
    <name>A0A3N6MU93_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88962">
        <property type="protein sequence ID" value="RQG88962"/>
        <property type="gene ID" value="EA462_11270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="80" mass="9035" checksum="8B4048A6292ADD99" modified="2019-02-13" version="1">MATVSVGSAQYSSRACENCGRTFNDKTGTIFALVRRWLSPHRDISKDKLTAYLIRSTVSRYRSDREPFCGRSGKKSQQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUK7</accession>
    <name>A0A3N6MUK7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89082">
        <property type="protein sequence ID" value="RQG89082"/>
        <property type="gene ID" value="EA462_11940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="62" mass="7200" checksum="62817C70FC03AC7B" modified="2019-02-13" version="1">MRSVCNSFQLFYIGPIQRTNHLEKSPQSVRPVGWVRSALLRTAGVFFRRFLDSLSVRCDRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUR5</accession>
    <name>A0A3N6MUR5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc-containing ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_12280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7 8">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7 8">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89142">
        <property type="protein sequence ID" value="RQG89142"/>
        <property type="gene ID" value="EA462_12280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009157">
        <property type="entry name" value="Fd_Zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000068">
        <property type="entry name" value="Zn_Fdx_Sulfol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000068-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG89142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="107" mass="11683" checksum="FFB2588EEAA6D44F" modified="2019-02-13" version="1">MAIDPQFHENREQVDEHNGHAVWGPVDEPEELGIHGTHVAVDFDLCIADGACLEDCPVDVFEWVDTPGHPESEEKADPTKEAQCIDCMLCVDVCPVDAIDVDAGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUS4</accession>
    <name>A0A3N6MUS4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_12335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89152">
        <property type="protein sequence ID" value="RQG89152"/>
        <property type="gene ID" value="EA462_12335"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="7">
        <location>
            <begin position="6"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="260" mass="29750" checksum="A7001708B98C31AC" modified="2019-02-13" version="1">MVIEHDLHTHTTYSDGYDMREMADAAAEAGLSGIGFTDHCLPYEDPFGRRRMYDLEETYAERRSDIDEVRATTDVEIYDAVELNYDPNRESEIRSFLDEAAFDYAIGSVHYADEYYVMENEDFVDRSETAKRTAIETYVDWQVRLIESDLFDSIAHVDVTQRRPSLRGVMNDGDYRRIAEALVDSDTVLEINAGRLDRPYATVHPHPDFLSIFGDYDVPLVAGTDAHAPDQVRRRTQLLSSFAEKMDLQFVGTESVLSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0R4</accession>
    <name>A0A3N6N0R4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lycopene cyclase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_05945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91502">
        <property type="protein sequence ID" value="RQG91502"/>
        <property type="gene ID" value="EA462_05945"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016120">
        <property type="term" value="P:carotene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="100" mass="11022" checksum="DE376252BDB71356" modified="2019-02-13" version="1">MRPDISVFGRYTYLVTELFWGTVALVLLQRAGALRKAAVTILALYPIAYVWDRYTLAVGVFDINLRTGVDVAGIPIEEHLFMAVVPGLVLGIHETIFGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N126</accession>
    <name>A0A3N6N126_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91642">
        <property type="protein sequence ID" value="RQG91642"/>
        <property type="gene ID" value="EA462_06755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="250"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="395" mass="42075" checksum="C12BAE1D094EEEF7" modified="2019-02-13" version="1">MVDRPLRERLPENWRRALTTRATVAFVLVVALLSVATAILNIGTDTVYEPFTPYIPAAVQDTASFTGALTGFLMVGSALALRRGLRAGWWATLLLLPLTAVQGLLQVSPYSLPLIVLSLVSIPALLLTRDRFTKPLALGTTQIAAGSALVGVQAYGTIGGYALRDHFDGIDTVLDAFYFTLITSSTVGYGDVTPNIDSTEGMLFTMSVLVLGVASFGIAIGALVGPAIQARITKTLGKMTDSELELLSEHILVLGYGELTEPIVDELSATDREFAVVAKNRDVMDDLSDRGIPVVVGDPSDETPLRRAKIQNANAILVATNQDAQDALSILTARQLAPDTRVVAAATDLENTKKLERAGADAVISPALLGGHLLVRSALGRDDSELLERLLTENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3X7</accession>
    <name>A0A3N6N3X7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminodeoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_01160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92862">
        <property type="protein sequence ID" value="RQG92862"/>
        <property type="gene ID" value="EA462_01160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG92862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="297" mass="32020" checksum="EF27605D77441F7D" modified="2019-02-13" version="1">MTDELRYHVDGELVPASEAAVSVDDRGFRYGDAAFETLRAYGDTVFAWDAHVERLEETCAALSLDHGLSSADLRGRIDETLSGNGLSDAYVRLSITRGVQPGKLTPHPDVGPTVVVYIKALPRGGLEGDPVWDGPAAVRTVETRRLPDEAIPASAKTHNYLNGILARAELAGSTGSVDAPDEALMLDLDDSVAEGATSNLFFVRDGTLHTPSTDGPVLPGITRDIVLELARECDLPLEEGRYGIDDVREADEAFLTNRTWELRPVGTVDGVEIGGGPVTARLSRLYDERVESACYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NU72</accession>
    <name>A0A3N6NU72_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PKD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_16185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86680">
        <property type="protein sequence ID" value="RQG86680"/>
        <property type="gene ID" value="EA462_16185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="176"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="442"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="590" mass="66238" checksum="C4BB64F8746767B3" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUU2</accession>
    <name>A0A3N6NUU2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_15195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86990">
        <property type="protein sequence ID" value="RQG86990"/>
        <property type="gene ID" value="EA462_15195"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="328"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG86990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="403" mass="43635" checksum="62E1435A9E8DAEA6" modified="2019-02-13" version="1">MLDRSDVLEARERVRETARHTPLEYSYTYSAMTGADVHLKLETFQRTGAFKIRGATNRIATLSADQKAAGVVTASAGNHAQGVALAATRVGVDSKIVMPEHAPISKVKATRNYGAEVVLAGADYDEAAERAHEIERKENRTYVHAFDDETVMAGQGTIGLEIAEDCPDVETVVVPIGGGGLISGIAAAIKGDNPDARVIGVQASGAASAARSLEKGERVSLEGVDTIADGIATRRIGERTFAHIREYVDEVVTVSDPEIAVATVYLLERSKTLVEGAGAVPLAALLFEKFEYETDETIVPVLSGGNIDLNTLTNVIVRGLVETGRYLKIRTVLTDQPGSLERLLEIFTVHRANIYAIYHDRTSRDVEMSDTEVEIELEMRGPDHVEEFLSDLREAGYEVDVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVU1</accession>
    <name>A0A3N6NVU1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88012">
        <property type="protein sequence ID" value="RQG88012"/>
        <property type="gene ID" value="EA462_14235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="146" mass="16572" checksum="BF58F99765A43D94" modified="2019-02-13" version="1">MSADIRLLKSSYFTFEHDGDEIPTVTDIELPEQRIEQITHDNGNPDPVQETQGRLLFGDLVVHRDIKADMSTKLYDEHDLAATTGDTSAIKKPLTIFIKDQESTTISTLKFTGTWVKEYHPPTLCAMRSDTATEMFVISVDYMEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVW4</accession>
    <name>A0A3N6NVW4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="3">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">icd</name>
        <name evidence="7" type="ORF">EA462_14420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88042">
        <property type="protein sequence ID" value="RQG88042"/>
        <property type="gene ID" value="EA462_14420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="PTHR43504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00183">
        <property type="entry name" value="prok_nadp_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="6">
        <location>
            <begin position="32"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG88042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="422" mass="46675" checksum="B438D86AE9E89719" modified="2019-02-13" version="1">MEHDYGDVTVPAEGERIEVDDDGELIVPDEPIIPILFGDGVGKDVSPAAKRVLDTAAELTGRTVHWMRIYGGETARERYDENLPEDTVNAIREFRVAIKGPMTTPVGSGYRSLNVALRKKLDLYANVRPTYYLNGVPSPVSEPEQMDMVTFRENTEDVYAGIEWEAGSDDVSRVRDFVETRMGYEGAIHEGDVGIGIKPISEFGTKRLVRRAIDYALEHDREYVTLVHKGNIMKYTEAAFRDWGYEVAREEYGTEVITEDTLWEEQDGEVPDGTVVVNDRIADNMLQQLLTRTDEYDILATPNLNGDYLSDAAGAQVGGLGVAPGANFGTGLCLAEPVHGSAPKYAGQDKVNPTALMLSGRIMFEFLGWNDAADLIRDSIEDTIASKKVTYDLARHLDDAEKLSTSEFAETVVETMKTDGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWA4</accession>
    <name>A0A3N6NWA4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88799">
        <property type="protein sequence ID" value="RQG88799"/>
        <property type="gene ID" value="EA462_10360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="73"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="198" mass="21176" checksum="40B5266516C79DA8" modified="2019-02-13" version="1">MTDVLVPGGRDVRGSLEPADGADAIVVACPPHPRQGGSRRDSRLLALEAALQERSIGALRFDYGAWDEGNGEREDVRNTVRWASERHDRVGLFGYSFGASLALLAAGDVDGIAAVSALAPTARIGDDLDAVAALGALEVPVQIVYGERDTTAEWEPVVEAADVRELDSRIEAFPADHFFVGNEVDVAERVGSFFEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWG5</accession>
    <name>A0A3N6NWG5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AzlD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88889">
        <property type="protein sequence ID" value="RQG88889"/>
        <property type="gene ID" value="EA462_10860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="105" mass="10729" checksum="86F3824CFC85853F" modified="2019-02-13" version="1">MTAESLSLDPVVVGVVLAMAVVTAVTKVGGIWLVRRVEVSERLEAGLSVLPGAIVIAILAPELTAGGPAEWGAAGVVLIVMWRTESILLALCAGVLGVVLFRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWH3</accession>
    <name>A0A3N6NWH3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88899">
        <property type="protein sequence ID" value="RQG88899"/>
        <property type="gene ID" value="EA462_10915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="62" mass="7167" checksum="9D06E7BEF4F8D853" modified="2019-02-13" version="1">MVPKTSPFERLREKFEETELACRQCGYHDTDGGWRVTTSGSRVQYQFVCSSCSAVDTREMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWV6</accession>
    <name>A0A3N6NWV6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89069">
        <property type="protein sequence ID" value="RQG89069"/>
        <property type="gene ID" value="EA462_11870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046243">
        <property type="entry name" value="DUF6276"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19792">
        <property type="entry name" value="DUF6276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="144" mass="15589" checksum="482ADC043E868AE9" modified="2019-02-13" version="1">MTCTTCGARTISFSVPPAFLEYAPDGASMVTFCTHCLALESEDTTSVDSETGVDVESEEDEIPAFGRVSDSFPTDPDQAIPLALTIGHCSSLATNREAIESLLRDVERAGTDPLLALERLTDDPTVDPAIDLERRAHQLEQLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYS1</accession>
    <name>A0A3N6NYS1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86212">
        <property type="protein sequence ID" value="RQG86212"/>
        <property type="gene ID" value="EA462_16975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="705" mass="74827" checksum="5FEA936C1CC9B1D6" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYT7</accession>
    <name>A0A3N6NYT7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90039">
        <property type="protein sequence ID" value="RQG90039"/>
        <property type="gene ID" value="EA462_08545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="322" mass="36210" checksum="D0ACEBE975F4EDE3" modified="2019-02-13" version="1">MEIGVHTPPLADESLEGALAYLSEFGVDAIEPGVGGHPGDDHLVRREYLDDEQAQAELRELLETYDVRISALAIHNNPLHPDDDRGDRADTELREAIELASQLEVGTVTCFSGLPAGGPNDEVPNWITTPWPPEHAEALAYQWNVALEYWDDLAAHAADHDVDVAIEMHPNMLVYEPSGMARLREETNDRIGANFDPSHLYWQGISVTDAIRFLGERNAIHHVHAKDTRIYDEQARLKGVLDTTAYDDEPNRSWLFRSVGYGHDESHWKEIVSTLRIVGYDDVLSIEHEDSLTSSREGLEKAIELLERAVFRTEPGEAYWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZJ4</accession>
    <name>A0A3N6NZJ4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="1">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="1">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thpR</name>
        <name evidence="2" type="ORF">EA462_15095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86976">
        <property type="protein sequence ID" value="RQG86976"/>
        <property type="gene ID" value="EA462_15095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="HXTX 1" evidence="1">
        <location>
            <begin position="39"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="1">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="185" mass="20403" checksum="8D1AFAA60DCE2072" modified="2019-02-13" version="1">MRLFVSVDLPDEIVDPIAEIQREFADASGLRLADSDQSHVTLKFLGDVDESRLPSLRTELEGAVDDSGIAPFTVRYGGLGVFPDLEYISVVWIGTRTGGDGLTRLHEAIEDRATKMGFDPDHHAFTPHVTLARMEHAGGKELVQGLVRDRDPTIGEMRVTDVRLTESRLTADGPAYSTVERFPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0F7</accession>
    <name>A0A3N6P0F7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetate-CoA oxygenase subunit PaaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87958">
        <property type="protein sequence ID" value="RQG87958"/>
        <property type="gene ID" value="EA462_13935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="308" mass="35417" checksum="B828883E6C872ABB" modified="2019-02-13" version="1">MQPRVYDDMGVVERQLEELKSECKADDDVVVSRVSRGETIETIEEMSPNYLETLVEFMLTQHDTEIMSACAYHPAATQKAPTLDAKISGSAVVQDEVGHANLGYRVLSDLGFDKEALMYERDPKEWRNMRVFDEPFENFAEFACGVGFYDRAGTIQIGDIEENCSFGPWRRYERKVVAEEGFHKRLGDMWFKRLGSGTPEQQQALQDAVDKMFPKAIAFLGHPENEGKAIQQIREYSLRKGTNHEHRQEWLRQVYETFDSLEVDIPIGYDESEDEYDVTFDMDWKGVYSEWKESPGPVDHIQTVQGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1Q1</accession>
    <name>A0A3N6P1Q1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin carboxyl carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89025">
        <property type="protein sequence ID" value="RQG89025"/>
        <property type="gene ID" value="EA462_11625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="82" mass="8923" checksum="3912EDB304906F0D" modified="2019-02-13" version="1">MSETITINSPMPGVFYRRPDPEEAPFVEPGDSVDAGETIGLVEVMKNFHEIETDRAGTVSEFLVGDEAEIEADQPLVEIDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1R2</accession>
    <name>A0A3N6P1R2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-synthase adenylyltransferase MoeB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">moeB</name>
        <name evidence="2" type="ORF">EA462_11685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89035">
        <property type="protein sequence ID" value="RQG89035"/>
        <property type="gene ID" value="EA462_11685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="14"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="283" mass="30263" checksum="EDDC3AD039FDBDB0" modified="2019-02-13" version="1">MSDLRLDATQLDRYSRHVIMDEIGPEGQKRLLEGSVLVVGAGGLGSPAIQYLAAAGIGRLGLVDDDVVERSNLQRQIVHSDDDVGRPKVESAADYVAALNPDVDVDTDETRLTPDTVADLVAGYDVVLDASDNFATRYLLNDHCVLTGTALSHGAIYRFEGQVTTFTNDRDDHADEEGSDRPCYRCLFPEAPEPGTVPDCATTGVLGVLPGTVGCIQATEVVKYLLESGELLEGRLLMYDAMDMSFETVDILANPACPVCGDDPAIESVRDGSYEGSCSLSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4J3</accession>
    <name>A0A3N6P4J3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA_TRNA_LIGASE_II_ALA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_01250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92879">
        <property type="protein sequence ID" value="RQG92879"/>
        <property type="gene ID" value="EA462_01250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG92879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="424" mass="45687" checksum="7FB1EA03CE79AB5D" modified="2019-02-13" version="1">MSGQLAAAEPYATRFETAVSGIDGRHVWLERSYFYGESGGQPADRGTIGDIEVADVRIVDGEPVHVLAEDPSFKTGHRVLCSVDWTFRMYCMRAHTASHVLYGAGRRLLEDLGYGGFDIDEERVRVDLETSTPIDDEMLIELNESANRTVWESRSVSWDTVSASQAREREDVAFNEATETSAFENGQVRLVTIGGDDERNATGTRLQPSLGGGRSSEPWDVAACGGTHVRNTREIGPVTVLGRSNPGDGLTRIELAVGPRAIDRRTTEKRAVFGAKRTLGTSIGDVSAELERISDERDALADRLRTRERELVTERLLRGESIDCDGERWLVATVGDVSVDLVSDAVRDWIDDETDRTATSARVVVAVGNAEEPFAVVGSNGGRAATDVLSELTAAVGGGGGGSDRLAQGGGFDATVDEVRAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6F4</accession>
    <name>A0A3N6P6F4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl6</name>
        <name evidence="5" type="ORF">EA462_05105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91355">
        <property type="protein sequence ID" value="RQG91355"/>
        <property type="gene ID" value="EA462_05105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_A">
        <property type="entry name" value="Ribosomal_L6_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_L6_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019907">
        <property type="entry name" value="Ribosomal_L6P_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03653">
        <property type="entry name" value="uL6_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="91"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="177" mass="19543" checksum="2FF53EBFCFF6A77A" modified="2019-02-13" version="1">MRVELEIPDNVTVETDHLDVTVDGPEGTVSRRLWYPDVTVDVEDDTLVIESDTDDAKTNATVGTFESHVQNAFHGVTEGWEYEMEVFYSHFPMQVRAEGTDVVIENFLGEKAPRRTTIHGDTDVSVDDEVVVLTGPNKEDVGQTAADIEQLTKVSGKDTRVFQDGVYITKKPAKGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P706</accession>
    <name>A0A3N6P706_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siroheme decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_03690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ahb/Nir family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91685">
        <property type="protein sequence ID" value="RQG91685"/>
        <property type="gene ID" value="EA462_03690"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="248"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="346" mass="39089" checksum="C89EAC116D39F0B0" modified="2019-02-13" version="1">MSSLSRDWRDEIDEVDAAIIDGYQSDVPVDPRPFERIGAKVGVDELDALERVRRLSGLGIVRRFGAVLNPPVIGSSTLAAVQAPEERFDEIATTINEYRQVNHNYARDHDWNMWFVLTTGSRDTRDEIIDEIERRTGCSVLNLPMLTDYYIDLEFPVVNTDRFARESVAERTDSSATRISEEATGDLSSFDADLLLAIQDGFPLSATPYREIADDLEADLEAVLTGISRLKASGCIKRIGCIVNHVVTGFDSNCMVVWDVPDDELHERGERVGALPYVTLCYHRPRRPDQKWSYNLFTMIHGRDPGAVEEKIDELATKHLPVEHERLYSTETLKQTGARYDEILPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9P4</accession>
    <name>A0A3N6P9P4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">serB</name>
        <name evidence="12" type="ORF">EA462_01860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92985">
        <property type="protein sequence ID" value="RQG92985"/>
        <property type="gene ID" value="EA462_01860"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG92985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="211" mass="22156" checksum="5980E241FA886FC9" modified="2019-02-13" version="1">MTVVAFDFDGTLSDSEMTVLLGKRCGVADEMTEITERAMNDEIGYAESLRERAALLEGLPAEDADAAFDEVVLRPGAGNLIAELNEAGVTTAILTGGFERGVAAALEREDVSVDHIVSNRLPIRNDELTGEVEGSLVEGTKDDALETLAADVGVDLAETVAIGDGANDLPMLEVAGLSIGFDPKPAVEPHCEVVVTSMAEARRTLVDEGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9T9</accession>
    <name>A0A3N6P9T9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_02270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93055">
        <property type="protein sequence ID" value="RQG93055"/>
        <property type="gene ID" value="EA462_02270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="28"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="359"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="392"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG93055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="597" mass="66406" checksum="C44C93231916F9C2" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI95</accession>
    <name>A0A3N6LI95_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_15500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87044">
        <property type="protein sequence ID" value="RQG87044"/>
        <property type="gene ID" value="EA462_15500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="122"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="350" mass="40486" checksum="16D5295FD18E0883" modified="2019-02-13" version="1">MSDTLDPIPPAEAAEMYHHAMRDEHAAATRKSSRHRLQSFVQFCEEKEIENLNNVSGRDLYRYRIWRREGHGEGREPIKLVTLKGQLATLRSFLQFAANIDAVRPSLYEQVTLPTMKHGEDVSDSTLEVDRAIGILEYLEHAEPASREHIILLLLWRTGARTGAIRGLDLRDLDLEGAHPKVKGPAIRFVHRPESGTPLKNQEDGTRWNRISEMTAKYLENYLEYHRHDVTDDHGRKPVITTRYGRPAGNTIRKTLYKITRPCWRGESCPHDRDVAECEATYIDQASKCPSSRSPHDVRSGRVTYYRSEDVPRRVVQDRLNASEDILDRHYDRRTDRKQAQQRSNYLPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIG0</accession>
    <name>A0A3N6LIG0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isocitrate/isopropylmalate dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86969">
        <property type="protein sequence ID" value="RQG86969"/>
        <property type="gene ID" value="EA462_15040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="1">
        <location>
            <begin position="4"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="326" mass="34080" checksum="D3A21548B67831AB" modified="2019-02-13" version="1">MTDEITVIPGDGIGQEVTPAAVDVLESLEIEFAFHEADAGDHVKEETGEALPAETYDLAASTDATLFGAAGETAADVILPLREAVGSFVNVRPAKAYPGVDALRPDTDLVFLRENTEGVYSGHENRLSDDLSTLTRVVTSSASEQLAEFACEFVADGGYDGFHVAHKANVMRETDGRFRDSVLAVAEERGVETEEVLMDAFATHVCLDPTQFDVVVCPNLAGDVLSDLAAGLVGGLGMLPSANIGPERGLFEPVHGSAPDIAGEGIANPAATIISAAMLLEYLGHDDDGQAVRSAVEGVLEDGPRTPDLGGDASTDDVTDAVIDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIK8</accession>
    <name>A0A3N6LIK8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">ftsZ</name>
        <name evidence="10" type="ORF">EA462_15535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87049">
        <property type="protein sequence ID" value="RQG87049"/>
        <property type="gene ID" value="EA462_15535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 6 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="8">
        <location>
            <begin position="32"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="9">
        <location>
            <begin position="224"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="338"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG87049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="395" mass="41852" checksum="3FA47009AF695CB4" modified="2019-02-13" version="1">MQDIVQDALENAEQEAREMDADMDDDEFGDPRIVIVGCGGAGNNTINRLYNIGVDGADTVAVNTDKQHLTMIEADTKILVGKSLTNGLGAGGDPSMGERATEMAQSTVKEVLGDADLVFVTAGMGGGTGTGAAPVVSKIAKEQGAIVVGMVSTPFNVERARTVKAEEGLEKLREQADSIIVLDNNRLLDYVPNLPIGKAFSVMDQIIAETVKGISETITQPSLINLDYADMSTIMNQGGVAVMLVGETQDKNKTNEVVKDAMNHPLLDVDYRGASGGLVHITGGPDLTLKEAEGIADNITERLEASANVIWGARIQENYKGKVRVMAIMTGVQSAQVLGPTTQKQADKSRASIEGVNESNFDASNNVEHSRSGHGAQSDGGREELEKQNGVDVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIM6</accession>
    <name>A0A3N6LIM6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Recombinase RecA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87089">
        <property type="protein sequence ID" value="RQG87089"/>
        <property type="gene ID" value="EA462_15775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="207" mass="22424" checksum="638FD400AC3FC515" modified="2019-02-13" version="1">MYDLADVVPGAEIDPGSNVLIAGPPMTGKRQIGFEILRSGADRGDGSIIVTTKDSADKVLDEFSAATEDEGSDVGIVDCVTKQRGIGTVDDDARVKYASSPIDMTGIGIKLSKFLEKFYERRECTENRILLHSVSTLLMYSDLQTVFRFLHVFTGRIQSANALGVYIIDSTAHDEQTMNTLKQLFDGVVDVREGTDGPEITTAGIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJP0</accession>
    <name>A0A3N6LJP0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88943">
        <property type="protein sequence ID" value="RQG88943"/>
        <property type="gene ID" value="EA462_11160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WRKY" evidence="1">
        <location>
            <begin position="165"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="184"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="580" mass="63696" checksum="56EFCCDBF7E38B8E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJS1</accession>
    <name>A0A3N6LJS1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="3">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_10295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88788">
        <property type="protein sequence ID" value="RQG88788"/>
        <property type="gene ID" value="EA462_10295"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="41"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG88788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="189" mass="22031" checksum="87A5BE402FC2A2E3" modified="2019-02-13" version="1">MSTPTDELEHKNAAQDVIAVDENDSELELVNRLEAHTGDGIRHRAFTSLVFDQDDNVLLAQRSPDKRLWGTYWDGTVASHPVEGQSQEEATQERLEDELGISPDQYDGLRLTDRFEYKRYFEDQGVEHEVCAVLKLTLTDRTLDPNEEEVAGLLWVPYERLHSNPEWYRQLRLCPWFEIAMRRDVRSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJS3</accession>
    <name>A0A3N6LJS3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89003">
        <property type="protein sequence ID" value="RQG89003"/>
        <property type="gene ID" value="EA462_11495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="123" mass="12345" checksum="AA07219D99FF0B73" modified="2019-02-13" version="1">MSSSIRVFPSAIGLGIVLVLLGIGAYVGTGFASVTALIPAFFGVLIALFGVAGGRLDRERLATYGIVALSILGIVGSAQSVPDAIALLTGDSVDSVVATASQAVMILVCLVLLGVVALDRIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJU6</accession>
    <name>A0A3N6LJU6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1102 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88828">
        <property type="protein sequence ID" value="RQG88828"/>
        <property type="gene ID" value="EA462_10525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009482">
        <property type="entry name" value="DUF1102"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06510">
        <property type="entry name" value="DUF1102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="193" mass="19944" checksum="A16D3F9D2B731A95" modified="2019-02-13" version="1">MQRRKFLIGTGSTAIGASAIIGSGAFSRVEADRSLTVAAADDPDAYLGLVPLDTPNSNAYVELDANGHLEIDIATNENDGEGVNSNSITWFDGMFEICNQGTADADVYIEDIAGLGEDPGEVSFYTGTGAGDGDAGLDFIVGETESINIAVGTCEEIGVRVNSAEEQSDPVFDDDVTIIADSPDAGEPENGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJZ4</accession>
    <name>A0A3N6LJZ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89093">
        <property type="protein sequence ID" value="RQG89093"/>
        <property type="gene ID" value="EA462_12020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="380" mass="39852" checksum="36006DB5DC52D46A" modified="2019-02-13" version="1">MTEGSTTRTPQPSIRTALEEDIRVELEASDAAAYVHVGPTRDPGVRYCLAAQASGRGGHSGEDGFASDRRPLFEATVSALAFDGEWIVETAPPLSSTHPAQNLAARLAERVDGETVLTPAHIPHDSALHLENKGFSLASTDVVARGRGTKTADERARIERAQRAAGRGIRRAASLLADATVENDRLRLEGAELTPGRLRIAIDEGIVSAGGYPAGNTTVDPGADDGPLRSGDPIVLGASPRGAAGYYGGLVRTLVVDGEGGRERRAHVGVTQSFRSARAMLTAGAESVRSVETDLEAEIRAFGEDDAVETRVSGVGLEAMERPVDGGDNVEPGTVVRLEAAARVGGNGWIRIADVFAKGEDGVDRLEAPSRSLEPSTVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK08</accession>
    <name>A0A3N6LK08_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86688">
        <property type="protein sequence ID" value="RQG86688"/>
        <property type="gene ID" value="EA462_16230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="303" mass="32978" checksum="908B30A28FB69CBA" modified="2019-02-13" version="1">MSDLTTRSMELLEQAGTNPVAVEVDELEPLLDHENGHVRHTALRTLALVCEADPDRVRPVVDSVRDRVDDSYSIASSTALVVLSLVGETEPDAVRPIAPAIIDRLDDPSPGYRFRAASALVPLAEPYPDIFVEHADDLVDLLRENAAVDPMGSDALERDNLSPDRLRTMNEARTRDRGLSIAFREILAHLLVHVASVDPAAIAHRLETITDELDESADPVRQALVEVFRHVAEADAVDCEIPIGSLVALLEDGTPTTRARVVRTLGFAEAIEAVAPLRSLADRADDEAVSELASETADWLADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK75</accession>
    <name>A0A3N6LK75_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89153">
        <property type="protein sequence ID" value="RQG89153"/>
        <property type="gene ID" value="EA462_12345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010001">
        <property type="entry name" value="BofA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07441">
        <property type="entry name" value="BofA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="8563" checksum="59AFC4CB44BAD0C8" modified="2019-02-13" version="1">MVTGFEILLLVIVLAAVLGASTLVETVRPFIVNAVVGLLVLFVAQSVFGFSVAVTPVAIAIVAIGGVPGSLLVILLSAFGIAFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKF7</accession>
    <name>A0A3N6LKF7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminomethyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_12155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89118">
        <property type="protein sequence ID" value="RQG89118"/>
        <property type="gene ID" value="EA462_12155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="2">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="3">
        <location>
            <begin position="276"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="363" mass="38570" checksum="2FAC4DF01069EE79" modified="2019-02-13" version="1">MSVIESLHADHGATFGERGGRTIVEHFGRPERTHRAVRNGVGLIEAAYGVVVVEGADRLEYVDNVVSNRVPDEDGAGCYALVLDPQGRIEVELTIYNAGERLLLFVPPETAEPLAADWSEKVFIQDVEITVATDEYAIFGLHGPKATEKVASVLNGAATPDQRLSFVRGTMGESGVSVLRTDALTGEEGYEVICAATDAEAVYDVLLNQGMNAAPFGYRAWESLSLEAGSPLFETELEGRIPNVLGLRNALDFEKGCYVGQEVVSRVENRGRPSGRLVGLTLAGDPVPDAGAAVFDGDSSVGDVTRAGASEMLGDVIALAVVDYGLESEAVTVRVGGSERPATVTPLPFVEGSDRSGRLPMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLE9</accession>
    <name>A0A3N6LLE9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BolA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89793">
        <property type="protein sequence ID" value="RQG89793"/>
        <property type="gene ID" value="EA462_07175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="SSF82657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="83" mass="9247" checksum="9DF9D7A854CB7631" modified="2019-02-13" version="1">MKPAAVEEIIESKLDDCEATVTYARDEHDDDHLAATVVSPAFDGIPLVQQHETVYDALDGHMTTDIHALELSTYTPNEYDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLJ8</accession>
    <name>A0A3N6LLJ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89873">
        <property type="protein sequence ID" value="RQG89873"/>
        <property type="gene ID" value="EA462_07615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="67" mass="7266" checksum="318F9D4B65FCC5E2" modified="2019-02-13" version="1">MTRAESDEINLLDSPTFRYGIAASTTAILFVVAFWQFDGTVRWIVVALALANAVIVPRRLAAAAEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLK5</accession>
    <name>A0A3N6LLK5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4255 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88020">
        <property type="protein sequence ID" value="RQG88020"/>
        <property type="gene ID" value="EA462_14285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025351">
        <property type="entry name" value="Pvc16_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14065">
        <property type="entry name" value="Pvc16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pvc16_N" evidence="2">
        <location>
            <begin position="47"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="234" mass="25943" checksum="0B1697F79320E877" modified="2019-02-13" version="1">MPQLLRSYKISVQYGTQIRANPVSTVLPSTRRNTMNGFGAVAEASDLIVERLREETDSRGDVTTVEPSNIVLASPDDVTGNGNVRLSVFPYKISHEPRHGSPGRIQTQANTFKNPPLLLSCYYLVTAYPGSATDASAKVQDQQIALGLAMQILHDNAQFETEHLQGESSAVEAFQVALHSDSNDEIERIWDTFVDVPLHPSVVYEASPIPIESTTEERVTRVSERDLDLHDRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM62</accession>
    <name>A0A3N6LM62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_17015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86171">
        <property type="protein sequence ID" value="RQG86171"/>
        <property type="gene ID" value="EA462_17015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="304" mass="33831" checksum="BB33D92CF04D4340" modified="2019-02-13" version="1">MKLRYYADAPNVDDHEQIIDLLYTISDKYGITVDIERVNNRYGSIQVFPGSIRENSPEDVYDRDFHYNRTLGSNIDESPSQAFKASGRHVDIDGYVGIIDDGLIWATTYRGDSIGHGPDVDATDTTLGFLDQVATHGLEVIEEKYMDEDERERTVLEQFLAADVVDGTVHRDAVIGTSQLPDSPAHGVNSSVGKIVTRTVDAIIETDESDWIVQTAKTFEASRFDTALGQDLVRDRLYRLDTGKNTDTTLAIVFNTVPWELDTDAVPTTVDQLTAKTTRSVKRKICVGTSRTLPLHLPYSGDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM86</accession>
    <name>A0A3N6LM86_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl Co-A mutase-associated GTPase MeaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">meaB</name>
        <name evidence="3" type="ORF">EA462_08865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90098">
        <property type="protein sequence ID" value="RQG90098"/>
        <property type="gene ID" value="EA462_08865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="367" mass="39110" checksum="D8BADBC609B41B3E" modified="2019-02-13" version="1">MSPDDDSLIAELLAGKHRALARVISKIEDRSPGYRDLVSALYEHTGGADVIGITGSPGAGKSTLVDKLAQRYRDRDETVGIIAIDPSSPFTGGAVLGDRIRMASAVGDMDVFVRSMSARGTLGGLSTATMDAVTAMDAFGKDKIIVETVGAGQNEIDVVRAAETVAVLVPPGSGDSIQTLKAGILEIADVFVVNKADRDGADRTVQELREMIELESGHGFETAGHHGSNSTRNRHGTVLDEGRGGADDGDRDASQQRWRPPIVETVATTGEGVDSFIGELGAHREFLERSGEGVEKARKRHAEEIRTLLREDLNATLETELDRSGGVETLAETVRRGETDPYTVADEVLAPVTDCLEELDADESDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMC0</accession>
    <name>A0A3N6LMC0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88937">
        <property type="protein sequence ID" value="RQG88937"/>
        <property type="gene ID" value="EA462_11130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="93" mass="10527" checksum="40A6C093E4303A4D" modified="2019-02-13" version="1">MSTTISEDRIGAAEQPLSEDEYRDRLRELPPSAKLVAKVLEADSPLSQGQLAEESLLPDRTVRYALNRLEDVGLVGSRYSFRDARKQVYFLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMF0</accession>
    <name>A0A3N6LMF0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88977">
        <property type="protein sequence ID" value="RQG88977"/>
        <property type="gene ID" value="EA462_11345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="152" mass="16223" checksum="C7BD88568177BA09" modified="2019-02-13" version="1">MTLETILLAVGPGDTERSDELANAVIEVAEPTGASVVLAHVFTESEYDEVITRLDFDTDRDEIGSDEVAARHSTIRQLQTALEEHDIEYSIQGAVGEHGPTIVDLASESAADRVVVGGRRRSPTGKAVFGSTAQEVLLSSPCPVTFVRSDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMU5</accession>
    <name>A0A3N6LMU5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF502 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89197">
        <property type="protein sequence ID" value="RQG89197"/>
        <property type="gene ID" value="EA462_12590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="236" mass="25706" checksum="F2D3CE9B7A73F2B2" modified="2019-02-13" version="1">MASWKRDFASGLIVLGPILITLYVIYWIYGLVAGVTPGLILEAEALEPFVPGDSDQAQQTRVQLAQFLRVVVTLTVFTILTLSVGYLMRTTVGGLVERLVDNVANRVPVMRVVYNASKMAAETAFGEQESLQTPVKLEVWEGLRMTAFKTGKVTEDGREVLFLPTSPNITTGFVIEVESDRVEELDEDVEDALTRVLSAGFGDADRQRGMDAGVSIDVIDEATAGTKSEKADADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP66</accession>
    <name>A0A3N6LP66_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88047">
        <property type="protein sequence ID" value="RQG88047"/>
        <property type="gene ID" value="EA462_14450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="147" mass="16517" checksum="B67DC03FF675E100" modified="2019-02-13" version="1">MERYAINPKPLKDAREIGYNHGIVANGTFYMAGQVAMDAESNVIGDDIETQARKAYENVGILLDAIGKDFEDVAKVTTHIIDPHERYFDGYKTVYFETFDEPYPCHTVLGAHQLAHEKYLLEIEIEVPLSADDIDAIEPDGDVIRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPC2</accession>
    <name>A0A3N6LPC2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(3-hydroxyalkanoate) polymerase subunit PhaC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PHB synthase subunit PhaC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">phaC</name>
        <name evidence="8" type="ORF">EA462_04690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Biopolymer metabolism; poly-(R)-3-hydroxybutanoate biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91288">
        <property type="protein sequence ID" value="RQG91288"/>
        <property type="gene ID" value="EA462_04690"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00917"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042619">
        <property type="term" value="P:poly-hydroxybutyrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010125">
        <property type="entry name" value="PHA_synth_III_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01836">
        <property type="entry name" value="PHA_synth_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0583">PHB biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="71"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="449" mass="50176" checksum="29C7BF8C7867A6DE" modified="2019-02-13" version="1">MKNPYATALDIQRQAWEATADLAEKTRVSPDRTETLENIDVGPTPSDVVYEENKLELLHYESRTETQRDVPILIVYALINKPYILDLQSDRSVVQTLLEAGFDVYLIDWGEPSKLDRSLGLEDYVTRYIDNCVDVVRERSGRDEINVLGYCMGGTMSAMYAALFPEKVRNLALMAAGLCFAGDGGVLELWGAEEYYDPEQVTGAFDNVPAEFLDVGFALMDPVANNVTKYVRFYDNLEDEDFVENFARMERWLDEGIDVAGLAYEQFIREIYQKNALFENELHLDGEHVDLANVDMPVLQIVAEYDHLIPPNASKPFNDAIPAADTEILEFPTGHIGMSVSSRSHDELWPQVCDWFEARSNGDATGDEANGKRDDEGDVEREERAQGDLDDADDLTALNGVGDAYASTLLEAGIESFDDLSSADVVTLASETDISPSRLEDWIEQADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPC7</accession>
    <name>A0A3N6LPC7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR04024 family LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91303">
        <property type="protein sequence ID" value="RQG91303"/>
        <property type="gene ID" value="EA462_04765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023909">
        <property type="entry name" value="F420_NP1902A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04024">
        <property type="entry name" value="F420_NP1902A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="334" mass="36088" checksum="F789788BABF1CC32" modified="2019-02-13" version="1">MTDREIHLPVAAQPSVDSLVEYARRAESAGYGCVSLPETWGRDAVTVLATIAERTDSIDLGSSILNTYSRTPALLGQTAATLQEVSNGRFRLGIGPSGPAVVENWHGVAYGNPLKRTRETVEVVRQVLSGEPVEYDGESVSVSGFRLRCEPPEPVPPIEVTGMGPKAVELAGRFADGWHGIMLTPDGVRSRLEDVERGTDLGERDADDVRVTVGVTCCALSDGDRARALARQHAGFYVGGMGTFYRDSLVRQGYAEAETIHDAWQEGDRTRALDALDDDLLDELCAAGDPKTARETLRRFEGIDGVDAVTVSFPRGAEADEIRETMDELAPDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPR3</accession>
    <name>A0A3N6LPR3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88884">
        <property type="protein sequence ID" value="RQG88884"/>
        <property type="gene ID" value="EA462_10835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="135"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="265" mass="30706" checksum="F75B5907896CA2CB" modified="2019-02-13" version="1">MDGTLDHVMVRVSNLEDSLEWYESHLEYEEKDRHEGDGFTIVYLGPEEMHEEGALLELTHNEGTDELAVGDAWGHVAVRVPEGELEAYYEQLMDEGVEDYRDPESCGGRYAFVKDPDGHEIEIVQRDPDEGALWSLDHTMIRVEDADEALGFWTRKFEYDEVGRWESDSFANYFVEPRDAAEEAMSVELTYNYDGRSYETGDAWGHLCVRVDDLEEDWERLMERDAPEYRDPGSNDDMYAFTTDQDGHEIELLERDPDADSLFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPR9</accession>
    <name>A0A3N6LPR9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TrmB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90177">
        <property type="protein sequence ID" value="RQG90177"/>
        <property type="gene ID" value="EA462_09315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="250" mass="27864" checksum="891F36A64049F60D" modified="2019-02-13" version="1">MSVDENDAIEAFERLGLTSYEAKVFIALQRLGSGTARDVARIADVPRSQVYSVAERLENRGLLDVQQASPIRYRPVSLEKAQRTLEDRFDRECERALTYVEQVRNESTGEETQEDIWTVRGRERVDDRVVNLLSSADERIVFGTRLSELVVDPIERCLEEQANEGTAVVVMSQNDSVRNRLGSIEGVCTDAPPSHHEGDRRSGRIVIVDDDGVLLSVIDDDGGETAIWSSGSRFASVLIQLIEVSTQTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPS7</accession>
    <name>A0A3N6LPS7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">trpB</name>
        <name evidence="15" type="ORF">EA462_09420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90197">
        <property type="protein sequence ID" value="RQG90197"/>
        <property type="gene ID" value="EA462_09420"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="14">
        <location>
            <begin position="68"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RQG90197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="442" mass="47609" checksum="7F885434014D367C" modified="2019-02-13" version="1">MSTSERDHERGDQRERTSHGSFGEYGGQYVPEAVMPALQELEDAYERYVLENEDGFMDEFRERLRDFGGRPTPLQRADRLSERYGREIYLKREDLVHGGAHKLNNALGQVLLAKYMGKERIVAETGAGQHGTATAMAAAHLDVPCEIYMGRTDVNRQRPNVYRMRMNGAQVNPVDAGSGTLKEAINETMRDWSTTVETSHYVIGSVVGPHPFPAMVRDFQAVISDEAREQLLESAGRLPDTVIACAGGGSNTMGAFDAFIPDADVDLVAVEAGGSSLEIDEGDGIAPNSATLSTGSDGVLHGAMTKLLQSDDGQIMESHSVSAGLDYAGVGPELSHLVETGRVRPVNVDDETALEAFHRLSTLEGIIPALESSHALGYLERAAGPAAKTSNEQHAQEAAEEGLGDLVVVNVSGRGDKDLETVLEETEARDLAAAPDVEVFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPZ8</accession>
    <name>A0A3N6LPZ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_11445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88994">
        <property type="protein sequence ID" value="RQG88994"/>
        <property type="gene ID" value="EA462_11445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023135">
        <property type="entry name" value="N6_DNA_MeTrfase_TaqI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025931">
        <property type="entry name" value="TaqI_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12950">
        <property type="entry name" value="TaqI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="9">
        <location>
            <begin position="702"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="TaqI_C" evidence="10">
        <location>
            <begin position="932"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG88994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="1292" mass="141312" checksum="E423C7D28D13B299" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ31</accession>
    <name>A0A3N6LQ31_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90337">
        <property type="protein sequence ID" value="RQG90337"/>
        <property type="gene ID" value="EA462_10205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="68" mass="7685" checksum="ADFDFCF4A0CD9859" modified="2019-02-13" version="1">MSSNEIGARAPCQHVIEWRVNQPDCSERERRRLEAIREEGITTESQADLLAGACRDSGMRDVCEHAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ41</accession>
    <name>A0A3N6LQ41_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="8" type="ORF">EA462_06935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91673">
        <property type="protein sequence ID" value="RQG91673"/>
        <property type="gene ID" value="EA462_06935"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="433" mass="46021" checksum="29D7C177C9E93A80" modified="2019-02-13" version="1">MNVDIGNALASVSAPGVSRGSLEALDEQVAAAHERIETGRANREHGYEALNLPDRTDPETIRSAVEPIADADAIITVGIGGSALGAATITDALAGESETEAIYLDNVDPEWVSSRLERLPLERTAINVVSRSGTTAETLANFLVVRDAFESAGVDWTDRTIVTTGDSGPLRDLSDRHDLPSLKVPDGVPGRFSALSSVGLVAPAVCGHDLEALLEGAAAEADSLSGSLFECPAYAYGATTYALDARGAGINAMVPYSESLETSAEWFAQLWAESLGKDDLGQTPVRALGVTDQHSQLQLYRAGPRDKFVTFVTTRQRRDRSIPETDVEDLAYLGDATLGELLEAEFEATEASLAAAGRPNVRIELESVDEYELGGFLYGMEAACVLAGELYGVNTFEQPAVEWAKKATRGLLGGGAFEEAEAVAEKTELRIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ60</accession>
    <name>A0A3N6LQ60_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_04825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91703">
        <property type="protein sequence ID" value="RQG91703"/>
        <property type="gene ID" value="EA462_04825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="45"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="5">
        <location>
            <begin position="434"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="709" mass="76769" checksum="C4220A6C41BCCAD1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRR2</accession>
    <name>A0A3N6LRR2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_03785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91127">
        <property type="protein sequence ID" value="RQG91127"/>
        <property type="gene ID" value="EA462_03785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="12"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="256" mass="27565" checksum="73D2E2048E732300" modified="2019-02-13" version="1">MATEPESGSAAVAADAVRRTYRLAEPVHAVDGVSLSLGKGSFTAVMGPSGSGKSTLMNLIGCLDTPDEGRLEVGGRSVSQLSSADRARLRGTEIGFVFQTFNLMARLTAAENVTLPIVFHDAIDENRKERARTLLDRVGLGDRLDHRPSELSGGQRQRVAIARALANDPTLVLADEPTGNLDSETGAEVMDRFVELNRQGTTIVLVTHERAIAEYADHVVHLVDGRIEELEHLGTSRDVTVTAGEESTIRGNVDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS32</accession>
    <name>A0A3N6LS32_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90044">
        <property type="protein sequence ID" value="RQG90044"/>
        <property type="gene ID" value="EA462_08570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="206" mass="23352" checksum="1AD72AA6A61804A5" modified="2019-02-13" version="1">MSESTTDESNVTCGCKVGRIGQRYGLSNLDDELVRYWTDRTDERYSTRELAEHMNQRVLQAALDDAGLQYRDGEIENTYRLLTGDDVSSGTRVQTRKELERDSVPVEDIEGDFVSHQTVYNHLTNCLEAELESPSDEERLERSRDKLGALRNRTAAVTEDTVAQLDRNDVLDVGEFDVLVNVTVTCKDCKQQYTVRDLLEQGGCDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS79</accession>
    <name>A0A3N6LS79_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Segregation/condensation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92743">
        <property type="protein sequence ID" value="RQG92743"/>
        <property type="gene ID" value="EA462_00480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="349" mass="38755" checksum="BC50F1307890B120" modified="2019-02-13" version="1">MTSDERSSSETRSRGDASGGPETTERSSRLRTDGGDDVPLNIAGHEDREPPGVSSDDGGTLLEFSEDGAGTSSGSNGGDEDDENVEPVELLVQLAKDGEIDPWDIDVVRVTDKFLEVLDDADLRTSGRALFYASVLLRMKSDELFAPDEPDEEELPPWEAPFADDAGATGESGDHPPGFDPIEGLEAEMERRLERKQARGKPETLDELVRELRSAERGTWWKESRSYDTSNSPSGYDRGVQELSYHSEDQFRIDDEPTSDDVTHTTHEEDIETVIDGVESVLEDHYEKGRDEVLYAEIDETGGSRVMTYLALLFLAHRGRIRLEQDELFGDLWIQEATLEAEPEEAIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSJ2</accession>
    <name>A0A3N6LSJ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenic-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90264">
        <property type="protein sequence ID" value="RQG90264"/>
        <property type="gene ID" value="EA462_09805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="183"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="399" mass="43103" checksum="580061C318EBEF66" modified="2019-02-13" version="1">MSGIDVEPVEEEDRTEATHDDGAHAIEVTPTDDVGSASDRETIEVEPSDEPLEGPEYVLYGGKGGVGKTTMAAATALDSARGGTRTLVVSTDPAHSLSDTFETDVPAEPGRIRDDVPLFGVEIDPEAAIESGKATFPGTGAGSDAGEGAAFDSDTGIGGGAGDLGGLGEMLGGENPMDALFGGAMPGADEAAAMQLLLEYLDDPRFERVVVDTAPTGHTLRLLQLPELMDSMMGRLLQFRQRIGGLFDQMKGMFGDDVPEQAGGMEDLEALRERIERLRAALRDPERTDFRIVMVPEEMSVFESKRLRQQLEEFDIPVDTVVVNRVMEPLSDVTEDVTGEFLRPNLEDCAFCQRRWDVQQQALSEAQELFRGTDVRRVPLLAEEVRGEGMLEVVAACLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSN7</accession>
    <name>A0A3N6LSN7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_01825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92978">
        <property type="protein sequence ID" value="RQG92978"/>
        <property type="gene ID" value="EA462_01825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="707" mass="78844" checksum="E9DC8BE066F5C0E1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSS0</accession>
    <name>A0A3N6LSS0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA starvation/stationary phase protection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_09665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90384">
        <property type="protein sequence ID" value="RQG90384"/>
        <property type="gene ID" value="EA462_09665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="31"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="181" mass="20607" checksum="18A72A2F7DC1E97F" modified="2019-02-13" version="1">MSTQKTVRQSADAVEENELRLDQEKAEQIVDALNTELANSYVLYHQLKKHHWVVEGAEFLPLHEFLEEAYEHVEGGADVIAERAQALGGVPVSGPANQERRATVEFEGEDVYDVRTMFENDLEMYGDIIESMRDSIELAENLGDYATAEILREILVTLEEDGHHFEHYLEDDTLVLEEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSX8</accession>
    <name>A0A3N6LSX8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91687">
        <property type="protein sequence ID" value="RQG91687"/>
        <property type="gene ID" value="EA462_03710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="6663" checksum="C857A270C8479D23" modified="2019-02-13" version="1">MVDGEHVVLLLEEDGTTVDQHVASVDEFDTIAEGDILIVLIGDDELLWYRIVPERPSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LTE2</accession>
    <name>A0A3N6LTE2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93313">
        <property type="protein sequence ID" value="RQG93313"/>
        <property type="gene ID" value="EA462_02650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="39"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="357" mass="37595" checksum="CCAAAD4E48112D6B" modified="2019-02-13" version="1">MTFVLGRDGDLEAGLSGHLGYYRALDGSRGAMLHVDLDGPHAVLIVGKRGYGKSFTLGVVAEELSRAPGVSPVVIDPMGVFATLAESAGETTVSASVLESPAVTPTSLDPRSWCELLGLSPESGAGGLVWRAAQEAATIEGMCTHVDASDAPGTDRRAAINHLELARSWGVFDDAGVSADDLAGGDVTIVDVSGLDSAPMNAVCRAIAEDLYRARVTGRVQRLPWLLLDEAHTFFTGVADPALRRILTRGRAPGVSLVLATQRPSAVPSVAISQTDLLLSHRLTSRADLEALERAQPTYLRSSLDERMPTAPGEVLVVDDATETVHAGRIRNRETPHGGDSPSASAVSITDERADRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUJ1</accession>
    <name>A0A3N6LUJ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91224">
        <property type="protein sequence ID" value="RQG91224"/>
        <property type="gene ID" value="EA462_04330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="132" mass="14477" checksum="72DB5B363F7C8493" modified="2019-02-13" version="1">MSLETMQPNPAWDAASYEDAVDTLESHTDELVYRVWGGDWCKDCRKLLPNLGAALEAAGVSADRIEEIPVDQDKQGPGVEEYGIEYIPTVVVERAPDGLNGDGEEVTRFVEEEDLPPAVWLANEIDATLSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUW4</accession>
    <name>A0A3N6LUW4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF63 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91394">
        <property type="protein sequence ID" value="RQG91394"/>
        <property type="gene ID" value="EA462_05325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002749">
        <property type="entry name" value="DUF63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40700">
        <property type="entry name" value="PTHR40700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01889">
        <property type="entry name" value="DUF63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="273" mass="28634" checksum="F134EB0F652FAA82" modified="2019-02-13" version="1">MVLPEGFVVPPWYLLVPLLVVFLSAVSLLWTLEPPVTDRTVLAFAPWMMIGAAAHVLYRLEVYPDAIAVLFASPGVYLVTATVGGLVWILGTFLEAAGLQRTAERFLGSVGVVVFAVSVIVVLVVGWEHGAVQPFWPVVAVVVSGLVTALAWLVLGLWFTDVAATTGATGALVVFGHALDGISTAIGYDVLGASEEVPVSRMILEAGGSLPTAEYIGAGWLFVAVKIALAMVVLGLFREYVDADPSQGRFLLALIAALGLGPGVHNVLLFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVI8</accession>
    <name>A0A3N6LVI8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-methyl-L-tryptophan oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_00505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92747">
        <property type="protein sequence ID" value="RQG92747"/>
        <property type="gene ID" value="EA462_00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PTHR10961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="3">
        <location>
            <begin position="6"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="375" mass="41520" checksum="8E7D5C18CC136749" modified="2019-02-13" version="1">MSERHDVIVLGVGGTGSAAVAQLADRGVDVLGLERYDVPHDGGSVNGLLRPLRLTDIEDPADVSLLRRAETLWRDLEADHDRRLLYRTGSIDTGPRGRSLVEEAKLACEEHDLEYELLSGEGLTDRYPAYRLPNGYETVYQPEGGFLRPAECVVAHVNRAHRLGATIRARERVVNWRPLDGGVRVETDHDAYEADRLVVTAGAWTPAFVDALDGIVTSERQVLTWLQPETPGHFARDRFPIWRVQTPSDLFYGYPTDSAPGATFGRSTNRNEVRDPDAFEHEPTQADERPLREFAREYFPAGAGPTMRMESGLAITTPDDRLLVDTLPEHPQVAIGVGPSESGFAYASVLGEILADLTLEGETDHDVERFSIDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWF3</accession>
    <name>A0A3N6LWF3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93177">
        <property type="protein sequence ID" value="RQG93177"/>
        <property type="gene ID" value="EA462_02960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="116" mass="12433" checksum="157CB8BA6EE735B4" modified="2019-02-13" version="1">MRRRSFIALTAVVPFAGCSSLLGGGIDTTIGEDERVEFEADEGAELTVTVDVEEVHELGDDMDVEREGIGFRLDHTEHGILDTRSIEGSETFEITVQNGGTHSVVIIGGVATVTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWL6</accession>
    <name>A0A3N6LWL6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93257">
        <property type="protein sequence ID" value="RQG93257"/>
        <property type="gene ID" value="EA462_03435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="118" mass="12542" checksum="B984FBEA105029FE" modified="2019-02-13" version="1">MGLETVESASPRSASPAARIPAAETSARGAISMSSERETADASSDDTASGLVCGRCDDPIRRDRVIRLSTEPCPELAERYEPVAKPYCSDCIAAIGMLAFATHPRSRCPTSRVARDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LX26</accession>
    <name>A0A3N6LX26_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86157">
        <property type="protein sequence ID" value="RQG86157"/>
        <property type="gene ID" value="EA462_16935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="65" mass="7056" checksum="469832AC15E23FBE" modified="2019-02-13" version="1">MGAKHDITTSRHLSIVAAKPGLRGRSVGFRIEHTAGVGCGITQKHARRNSVFLSYKVTNGIRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXU9</accession>
    <name>A0A3N6LXU9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="5">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rdgB</name>
        <name evidence="7" type="ORF">EA462_14675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86901">
        <property type="protein sequence ID" value="RQG86901"/>
        <property type="gene ID" value="EA462_14675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="182" mass="20287" checksum="F7D67B2783DB8902" modified="2019-02-13" version="1">MTVRFVTGNEGKVREARAYLEGIATVEQIEYDYTEVQSDSLSEIARRGAREGYEATGNDEPVLVGDTGLFVDALEGFPGPYSAYVEDTVGIERLWRLVSGEENRRARFRTVLAFADGDRTETFEGELAGTIVAPRGDEGFGYDPLFEYNGRTLAEMSLEEKNAISHRGRALAAFAEWYANYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXX6</accession>
    <name>A0A3N6LXX6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_00095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92674">
        <property type="protein sequence ID" value="RQG92674"/>
        <property type="gene ID" value="EA462_00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NOG1_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="NOG1_N" evidence="3">
        <location>
            <begin position="93"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="NOG1" evidence="2">
        <location>
            <begin position="259"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="364" mass="40693" checksum="F548BF31CAA5DBDA" modified="2019-02-13" version="1">MIFEDLPTTPTSEELIDKAFSRAARAGRSKGGLDAQQSMLQTAANIISDNLENVVTAWPDFEYEDDVHPFYYELADAILDVPDRRSEGETDADAPGGVDELRQSLSEVMWASRKAREIHDEYQSKLRKTDVDTARKHRKQAFARLADIVEQVDDELLYINKARNDLRDLPDIDPDEPTIVVAGYPNVGKSSLVNDVTNARGETAAYPFTTRGIGVGHFEGADLSAESERTERSAMDDHIRHQIVDTPGLLDRPPKERNEVEAQAVSAIEHLADCMLVILDPSAECGYPLESQLELRDAIQAQFEEVPVLTVANKVDRSEVWNDELVEEMDADYRMSVETGENVDRVLVAAVEAIDHEPQLPFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY88</accession>
    <name>A0A3N6LY88_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ugpC</name>
        <name evidence="9" type="ORF">EA462_16145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86672">
        <property type="protein sequence ID" value="RQG86672"/>
        <property type="gene ID" value="EA462_16145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG86672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="388" mass="42211" checksum="2CAD40EB4310505F" modified="2019-02-13" version="1">MARVNIDELTKEYNSPGGSIVAVDDLNLSMEDGEFVVFVGPSGCGKSTTLRCVAGLETVTDGAIRFGPEDVTDQKPKERDIAMVFQNYALYPHMSARENMAFGLKMSTDLSADEISERVEETADMMGIESLLEDKPKALSGGQQQRVALGRAIVRDPEVFLMDEPLSNLDAKLRAQMRTELQQLQKELDVTTVYVTHDQTEAMTMGDRIVVLNDGQLQQVGTPLECYHRPANQFVAGFLGSPPMNFLDVEADPEDGSLRHQNFTLPLSDSAPADLDGDRFVLGIRPEHITLTETPQTHAEPDRLIETDVTVTEPMGDVTNVYLEVGGTSVTVTTDGHVGVAAGDRIHMHVPGTKTHLFDAESGAAVKHSDEPIDSKPVTETSGRAETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY89</accession>
    <name>A0A3N6LY89_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_15730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87081">
        <property type="protein sequence ID" value="RQG87081"/>
        <property type="gene ID" value="EA462_15730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34702">
        <property type="entry name" value="PTHR34702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="95" mass="10108" checksum="C718597368568A43" modified="2019-02-13" version="1">MIPAGISIEEIFLLAAALFVVLAIMMFYRAVAGPTTQDRLLAVNVLGTNTVVILALLAAGLGEPWFLDVALIYALLNFLMAVAISKFTVERGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYB4</accession>
    <name>A0A3N6LYB4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87111">
        <property type="protein sequence ID" value="RQG87111"/>
        <property type="gene ID" value="EA462_15915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043067">
        <property type="entry name" value="CcbP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020994">
        <property type="entry name" value="Uncharacterised_Ca-bd_CcbP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11535">
        <property type="entry name" value="Calci_bind_CcbP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="118" mass="13878" checksum="F78BA5C396C6A0D5" modified="2019-02-13" version="1">MTRSDRDEEREERIKTRITVDTYSPEEAAMGWYAYLGDFLDFPFEARCVEQREESPLKEGETVRVVGMSSTEPTLSQMFVTVEWMNRELGVPLGQLEPIEPSADTEQAIEDWYYWLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYD7</accession>
    <name>A0A3N6LYD7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92874">
        <property type="protein sequence ID" value="RQG92874"/>
        <property type="gene ID" value="EA462_01220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="195" mass="21610" checksum="58BD2AB02A55B61B" modified="2019-02-13" version="1">MSNERTYPDEPAGPFPSPDTAFEDRDGRSIEIRAPESMTNGALDDIVDMYVRFDPTDRAQGIPPTGETRIRSWLEGITDRSVNVVATHGDDVIGHAMLVPDVDDPPSLDDAGDAEWELAIFVLQEYQRAGIGTELLEHLLGHAADVGIERVWLTVERWNQPAIALYERVGFDSTGTESFEQEMAILLEAGGERNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYF6</accession>
    <name>A0A3N6LYF6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86762">
        <property type="protein sequence ID" value="RQG86762"/>
        <property type="gene ID" value="EA462_16645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="209" mass="22949" checksum="BB3D5A056CDB6359" modified="2019-02-13" version="1">MYDTHFGTDWETIDSHEEVVRRAFALGVATRLGENYPDELDRLGAVIETSYDQSFVELAYHKGRTEAGATKRTSDADDEEVWDTLVEEKIVIEAPDEESTGAFDGEELYERTSLPGALQLVGIDTLPDDSTDRVSRPSFLDQMNSGSGPKSGEDRTVFGREIERVETDDTHRQDDDTSSGGVSGDDRTGGEGTGQNDSDGSQNDDDQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ03</accession>
    <name>A0A3N6LZ03_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93114">
        <property type="protein sequence ID" value="RQG93114"/>
        <property type="gene ID" value="EA462_02605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="479" mass="53093" checksum="6468B9F414C7C980" modified="2019-02-13" version="1">MTGERLLATRRLLWLREAETFYFNGTPDSRYRGEQHHQGKDPTSITFIVDFRCKPLEISGKTAILLSAILFIPPYIVQYKMVEGQRKTRRKWLSLCGGTVTGATILSGCADEDEQDRKPTDHDDGTDTGDPRSAGDWPMFGADLQNTGYQPDADGPTDDVTVRWTLEGGEQFNASPVVADGTVYAGCWDETLYAVDAATGEIEWEQENLGLISSSPTVVNETVYLSTSSNDIYAFAVNNGEIRWKEEFDRTTKNPIPVDRTVYALDPGRLVSTVGSSGETTVVLDDLGGAPEAPAIDDDVLYIGGNDSARFYDLESFELTWEFKNPNSERMSDRPPAIAENVAYISGSDSKVYAIDVKNKEQKWTYELNERTPSGPSVADGVVYFGSWNNYLYAIDAETSEKEWKYDCGTILAEKPTVTAETVYMTGGDTVYAVDISTGEEEWSFTTENNETITGSPVVTDDALYIPSRNNHLYALEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZZ5</accession>
    <name>A0A3N6LZZ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87824">
        <property type="protein sequence ID" value="RQG87824"/>
        <property type="gene ID" value="EA462_13215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="76"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="471" mass="50494" checksum="D9D9227FCD10B11B" modified="2019-02-13" version="1">MGNESHTQENGAGTASNSRRHVLKAMGASGAVALAGCAGEGNGNGTNGNGNGNGNGDADTAPMGNYPIDGDTATYGFHGPLSGELAPDGVEQERGFELAIEHLNNGEGWADELDALSGDGVLGYEIDYVTGDSAGDEETSIDNIERMIDRDGIQFWTGGVSSGVCQALQPIAQREHVPFLSSISQDNEITGENCHRYHFRPSIGAELTARGLAEVLPDLLGENREYYQIYLDYSYGISNRESMESYMDDYGWEELGASPLPLGELDHSTAIADLDDSGADVLIFTTFGEAMANGLNQLDDAGLLDDIDIVIPLISAFSMEPAGGNAEGVYGATNWHANASDELDGQAAELSDMFVEDYQDEYGEMPGQAAIEAYDNVMVYSSVVESVGTFHPQTVVEELEGFSWDHGIGAMEFRECDHQAQRPVYVCEGLSEAEQEETGLFLDLLEIVPGEDAIYDCDHFPASECDMPGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M090</accession>
    <name>A0A3N6M090_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF418 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_11600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89020">
        <property type="protein sequence ID" value="RQG89020"/>
        <property type="gene ID" value="EA462_11600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007349">
        <property type="entry name" value="DUF418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04235">
        <property type="entry name" value="DUF418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="DUF418" evidence="3">
        <location>
            <begin position="253"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="423" mass="48138" checksum="032EEC5CAADECF4B" modified="2019-02-13" version="1">MPTDSSDDQETTDSGEPEPTDPSDRIVALDALRGFALLGILVINIWLFGMPTVATFNPALYGDFTGGNYLAWFISHVFFERKFVTLFTFLFGAGIVLFLESKDRKGQSGRKLHLSRTFWLLVIGLGHAYLLWYGDILVFYALSGFLVVWVWRWRPRRQFILGTALFSIPSILYLLTGLGYLSFSEDGRAEFEEELLAAFGADFSPEREIGIYQSGWLDQIAHRAPVLLEYHTLGFVFEMFWSVGGMMIIGMALYKWGIISNTRSTRFYKRVLVGVGGAGLALVLVGVWLREVFAWETVPVLTLAFQLNYWGALLLATSYIAGIMLLCRWIRDGVVVHALTAVGRTAFTNYLLQTIIATMIFYGHGLGLFGQLSRVELLGVVVLIWAIQIPLSVWWLERFRFGPVEWVWRTLTYRERQPMRLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1A4</accession>
    <name>A0A3N6M1A4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urea carboxylase-associated family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88861">
        <property type="protein sequence ID" value="RQG88861"/>
        <property type="gene ID" value="EA462_10705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="5"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="203" mass="22500" checksum="4B14AEEFB32D5741" modified="2019-02-13" version="1">MIDERIEEKRGISFAVDEGEQFEVTDPEGEQVADLVAFNRHDVSERFSPKYSYRRTNALRPTTGDTLYTTEGNPILEFVDDDCGVHDLLYAPCNHWVVGDYYGQTGEGGCRENLTDVLEPEGVLERDLQETLNVFMKSVVTDQTTVEIAEPESEPGDTVTFEAKQDVIVGIAACSGESTVNADETKPIDVTVPDGSVLHRNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2J2</accession>
    <name>A0A3N6M2J2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90030">
        <property type="protein sequence ID" value="RQG90030"/>
        <property type="gene ID" value="EA462_08470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="212" mass="22070" checksum="CC189BB8BF0239DC" modified="2019-02-13" version="1">MEGTPVTVESVADVGPDTIAIELETPEEFAAAPGQFVLLRAAPTGEEISRHYTLSSPSVTDSFEITVGIDPDGDLSPWLADLDGGETVHLEGPFGTITYERDEDVVAVAGGPGVGPAISIAEAAREASHAAVVIYQDDEPAHLDRLEALADDGASVLVLEEDADGDLADALEAHLEEGRLYAFGFDDFVTFVADVIDGAGGDADDALIENFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2Y3</accession>
    <name>A0A3N6M2Y3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF229 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90190">
        <property type="protein sequence ID" value="RQG90190"/>
        <property type="gene ID" value="EA462_09385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="460" mass="51915" checksum="4F2CD4AA8A25FDBB" modified="2019-02-13" version="1">MSNSPDVLFLVLDSLRMDRVSTYDHDRETTPALSTLSTYATTYENAFAPAPWTLPSHASMFTGTFPSEHGVTNGFSDDMCRLSPSRSTLADVLSEDGYRTAGFSNNPWVGQLSGLDRGFDEFVEWDLEISSEGDDSVHTSREELYSRCHSLLGKGARQPVFALKRRFFTDSLVDRTKRWIERGIDSAEPTFTFVNLMEAHSPYFPPKQAFEELGLEVPGPLEPRVLNTKLLAYVMGKTDLDPDTRRRIMEYYDASTRYQDRKVEEILSLLQREGVFDDTLVVVASDHGKTLGDYPRDEHPPHYLRDINLNVPLWIKRPGQREGETLEDMFELASLFDVVRDGNPPSGRYTRDVAIAEDFVPHAGRTTPDEVVRWRVAADEGNKYVRNDTGAEFLFDRSSDTLLRSPDPERCDVAAETLSERVRQFGRDDGAEHGGDDESNAPGREIDSGVEAQLKDLGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3A4</accession>
    <name>A0A3N6M3A4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_17025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86173">
        <property type="protein sequence ID" value="RQG86173"/>
        <property type="gene ID" value="EA462_17025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="144"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="374" mass="44104" checksum="B0CC8687C988B569" modified="2019-02-13" version="1">MSSREEDPEQPVSDDQLALLNARQKEVYNAKLVRFSEYLATEAKEPKRNIGYSDGVVAERVSRFHRMIKWLWTSEEVITEIGTDDLDKINLALEKDQLQKFDGDPYVDGSKRKFNDVLKNWCSFQNEDWQPEYEFSDNGPQKENRPDPFTKEELKLLTEAALTYKSIKSYSNQTPDERDRCRAYIAQELGKPKENVHPDDWEKINRSWKIPSLIRTSRGHGWRPDLVGRMKLQWYEPKTQTIHIPAGEAPKNDDPWNVELTDEEALYLENWLEQRELLECYDGRDEIWLNRKGNPYDSGPLNYLLRNLMEEAGIETRGRMLVWYSFRHAIGTYIYDEYRDLEIVAEQLRQNTTEAASKYVHKLPELKREAAEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3B6</accession>
    <name>A0A3N6M3B6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90360">
        <property type="protein sequence ID" value="RQG90360"/>
        <property type="gene ID" value="EA462_08050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002753">
        <property type="entry name" value="UPF0058"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036519">
        <property type="entry name" value="UPF0058_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42203">
        <property type="entry name" value="PTHR42203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01893">
        <property type="entry name" value="UPF0058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140371">
        <property type="entry name" value="SSF140371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="78" mass="8636" checksum="765DEB2B3E802C00" modified="2019-02-13" version="1">MKKQELIHLHGLLAEVSNQCAEWNNCQIDLEEYESLGIRPTSIHKSKTDHKAAVFAIAGGITTNMRDDEQEVVAATAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3H6</accession>
    <name>A0A3N6M3H6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86657">
        <property type="protein sequence ID" value="RQG86657"/>
        <property type="gene ID" value="EA462_16045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="289" mass="30490" checksum="820D687A8A3A3308" modified="2019-02-13" version="1">MAPAITHFLVGASLLLVLVTPIALRYDIDRENAIWLIPIGGVWGLLPDVHHITPVFETQLYALHNAAWMDLFGLHYTLDRQAIRVRYVESVFGAIGLFIVSVAVFWQTGRLRARAVASDGTPDRRLLSLVATAVAAGYGTVALGIAVSIQNGFPTVSALVGRDSVLVGGALLIPIGIGIGLFCGLGLETVLNLEHRTRPLSAALTGGLLGSAGWVGGVVVGVPMVLQISFASDAAPSVPFLHWGSLGGLIVYGTLFGAVYALVYGVFHEGSAKRSVSARGERTRVQKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4M8</accession>
    <name>A0A3N6M4M8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87117">
        <property type="protein sequence ID" value="RQG87117"/>
        <property type="gene ID" value="EA462_15950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="164" mass="18177" checksum="0E8B0D3317AF5346" modified="2019-02-13" version="1">MPINHDDIEPELSNAQEAFRHGGQTPEEGLDVSSADLVQLRKACRLLSGAERLLEDGYYTLTIEAAFTSIERTLLFWLITEGHHDPSQPPQSHTTAINRSAEVGFLTGEVATELEDLWNENRAHTYYQDGMATDDRADAMVALAGEIHSQIVNLVGQSHECICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M533</accession>
    <name>A0A3N6M533_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91120">
        <property type="protein sequence ID" value="RQG91120"/>
        <property type="gene ID" value="EA462_03750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="102" mass="11162" checksum="D768CD573793BB0D" modified="2019-02-13" version="1">MSQKPTPHDDVPAFIVERFADHSAAELRNIATYAESLETSIDVPQYVVQAFAIQDDETRTVVAIYAAELAAFLEEQAQRKSEDEEDDSSPPGPGRMGGAFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M535</accession>
    <name>A0A3N6M535_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90371">
        <property type="protein sequence ID" value="RQG90371"/>
        <property type="gene ID" value="EA462_08915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="61" mass="6791" checksum="1FC2A56651311346" modified="2019-02-13" version="1">MIDVSTLNDDDVMDRSENRTLPKGTATIETYEIDDGVVFYDAENPLAWVETSETIPLAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5C0</accession>
    <name>A0A3N6M5C0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91210">
        <property type="protein sequence ID" value="RQG91210"/>
        <property type="gene ID" value="EA462_04260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="241" mass="25988" checksum="EECEE8F0AD8B6C8D" modified="2019-02-13" version="1">MTRGAIVVGASSGIGEALARALAAEGYEVGMAARRRERMKRIGAELPTHTAVAKMDVSDPEDARDAFEDLAAAMTSIDLVVISAGVGHLNRGLEWEPDRETIDVNVRGFTAIATAAMAHFETQGGGHLVGISSVGAVFGNPGAPAYSASKAFVSTYLEGLRGRQADREADVTITTVEPGFVDTEMAMGDDLFWMASPETAASQIVRAIRRERDHVYVTRRWRLVAWFLKATPDRLLRRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7D4</accession>
    <name>A0A3N6M7D4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89266">
        <property type="protein sequence ID" value="RQG89266"/>
        <property type="gene ID" value="EA462_10770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="131" mass="15193" checksum="40922F62BEDAD553" modified="2019-02-13" version="1">MSAKTAKKYLDQLVEDNVLRTTEQGGQTLYCVDQLMATYREVASLQRDHHREELTDSLESMRARITDWKDEYDVETPGELRASIAGLEDRAEVERRRDIAGEWEHLDDRIPVVRAALNEYEWATKRDALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MAD9</accession>
    <name>A0A3N6MAD9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93300">
        <property type="protein sequence ID" value="RQG93300"/>
        <property type="gene ID" value="EA462_01805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="86" mass="9369" checksum="2B5FF83FB5F3362D" modified="2019-02-13" version="1">MDPLLDEDEPTGDLQDPVRKIDSETLLAFMFAVLFAHIGLFATSLGLMLIGFRGRWVVGSAVVVVGALGLVLTVAVYRRYRSKSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MB51</accession>
    <name>A0A3N6MB51_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92681">
        <property type="protein sequence ID" value="RQG92681"/>
        <property type="gene ID" value="EA462_00135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012022">
        <property type="entry name" value="UCP005295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42658">
        <property type="entry name" value="PTHR42658"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="333" mass="37265" checksum="60FD867633540194" modified="2019-02-13" version="1">MTSNYPTKRPTDAAHLEDEPDLPRELLNLPWIDIHNHAHTLSWEDRERYALAGCEGMVMVSSGYHWTPYKPVQAEDVRYLWDDAVNRRAAIERNHFFEAALGLGIHTGVRIEDPDELIDAMDAYCELDDVVAVGETGVTPSQHVEAWDVDEQRAITQAQMELANEHDIPVILHTPNTTTDSKRSYRPGLGAPGYEKNADLGAEPVLDVENPQLEAVTLDVQAARDAGLADERVVASHADGNNTEYLMAETECYLSYTIGHSWLVGVDAADVANVIDEYGPDRIMVDTDCANVLRTDPFALKRAIFELYRYGIDVDDIRRVVYENPREVFGLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCK5</accession>
    <name>A0A3N6MCK5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_05755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91466">
        <property type="protein sequence ID" value="RQG91466"/>
        <property type="gene ID" value="EA462_05755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008796">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03428">
        <property type="entry name" value="Ap4A_hydrolase_human_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003565">
        <property type="entry name" value="Tetra_PHTase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="144" mass="16660" checksum="299174A850BAAFAB" modified="2019-02-13" version="1">MAVEATSAGAILFRDTRGRREYLLLKSRPGDWEFPKGGVEGDEELQQTAIREIKEEAGIDEFRLLDGFREDYNYVFEANGTTIHKTVHLFIAKSFEASAELSHEHRDLQWRDYEQAVNTVTQDGPREILEQAHAFLDDREEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCM5</accession>
    <name>A0A3N6MCM5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucomutase/phosphomannomutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_03400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93251">
        <property type="protein sequence ID" value="RQG93251"/>
        <property type="gene ID" value="EA462_03400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="5"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="176"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="270"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="401"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG93251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="468" mass="49893" checksum="38634944770004F3" modified="2019-02-13" version="1">MDAITFGTDGWRATLEEFTAPRVRIVGQAVASYLSDEGLEGPVVVGYDARETSRGFAEELTRVVCANGFDVLIPERDRPTPLVAHAIVDRDLAGGLVITASHNPPEYNGVKFIPNDGAPALPAVTEAIADRLAEPDPRPESEHGTAREIDLVTPHADAAVDLAASITGGEDRDLDLSGLTVAYDAMHGSGRGTTDALLERVGVSVDRLRCVRDPEFGGGAPEPGEQHLGELAALVTDPETEPELGIANDGDADRIAAVTPERGFLDENLFFAALYDYLLEGDSGAVIRSVSTTYLLDRIAESHGERVHEVPVGFKWIAEAMADHDALVGGEESGGFTVRGHVREKDGVFVALLAAAMHAEEPLDDRVDRLLAEHGAVVQDKRSLACPDHEKARVLEDLGDEIPDSVAGTPVESVTTADGFKLQLADGSWLLVRPSGTEPALRVYAEASDRDRIDSLLEAGTELLEPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFN9</accession>
    <name>A0A3N6MFN9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92726">
        <property type="protein sequence ID" value="RQG92726"/>
        <property type="gene ID" value="EA462_00385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="253" mass="28355" checksum="9EA994563C6AD75C" modified="2019-02-13" version="1">MRDDGVEPESDSGLEDVSTVEGRREPDRRRRLETRAGSGSLSRADVRRDSTVRRWGVVTPSATVIGRPDSPEGDLSESIRRLHDEQHAATPGYSERAHHLDRLRTTQALCNALEVTPWQRDLALGVMDEIDLTEFGSQRAISKVALVVIRHVVDADRQAYFGLDDIDTQALSADRMDELFGQYRAHDITDESTFRRLAGQIGLDTTSLNRLRRVLRAQLEDELPAYGRNPYRDPNLPEPSLGSDEPDVDETPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MQW1</accession>
    <name>A0A3N6MQW1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86209">
        <property type="protein sequence ID" value="RQG86209"/>
        <property type="gene ID" value="EA462_17225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="243" mass="27757" checksum="E9D143BCB263487E" modified="2019-02-13" version="1">MVMNEPLEFGHEDRRRIYEYVERHGSADLETVRERLGVDPSGFRHHVALLKRDNRLEEEQETLRVTIDAGTEEEYVTDGLEFQIRPARQDDLSGIVGAIRQVATEKTYIEAESVADEIDHQEALLRHNELESRMFFVATVERAVVGWVHLHAPELEKLGHTAELTVGVLEEYRGHGIGSHLLARGLQWAGSNGYEKVYQSVPSSNEEAIAFLEEHDWGTEAIRKNHYKLDGHYADEVMMAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTE0</accession>
    <name>A0A3N6MTE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_14545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88065">
        <property type="protein sequence ID" value="RQG88065"/>
        <property type="gene ID" value="EA462_14545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG88065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="381" mass="42312" checksum="731C665F964B55F5" modified="2019-02-13" version="1">MDATEPQATSASESNASEADRDVAVQIANVTKEYGDVTAVDDVSLNVRDEEFLTLLGPSGAGKTTLLHMIAGFVTPTRGTINIDDVDVTHKPPYERNIGMVFQSMALFPHMTVGENIAFPLKMRRFDHDRIDERVQEMLDLIRLPEIRDRNVAELSGGQQQRVAIARGLAFKPSLLLLDEPLSSLDKKLREEMREELLRIHREAEVTTVHVTHNQEEALTMADRIAVIKEGEIAQHSSVQKMYSRPNSAFVADFVGNTNMLPGHVATVNEQRFSVDFGDDIVSTCQPSVVDTDPVADDQVTVGVRYEQVQIDERLDTDNAYNATVSDVIFMGDVINYKAEIDSLGVEVNISELNSKDVDVFERGDAVQVGWEDDDTLVYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUG5</accession>
    <name>A0A3N6MUG5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89042">
        <property type="protein sequence ID" value="RQG89042"/>
        <property type="gene ID" value="EA462_11725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="192"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="432" mass="46751" checksum="2FF2FA8A621B3FA7" modified="2019-02-13" version="1">MSDVVRRARWQGALVVALLSSLLAVALGIPGLFVLAVVALGFVLVGQLSAEPDVDLCLERRLEESRVPPGRPVTVTLAVTNDGDRVLPDVRLADDPPDSVPVTDGALGFATAIRPGETITHTYELRPPRGEFAFGPATIRVRSLSATTAVTEKREPEGETTFRCETLLDSFPVQDRTIQFVGQTPTDDGGSGIEFFSTRSYRRGDPINRIDWHRFARTGELATIEYREERAVTVVFVVDDRPEVHRGSLDGGPDSYDLTLYAASRGVVGSLEDGNRTGVATLSGDTWIRPAAEDGVRRRWEDTADGQRTIADGGSLAVDLERRLPRRAQVVLCTPLTDRDAVDLAETLRTRDRDVTVVTPDLTTGVASRSVPPGARIAGLVRTNRIDELRSVGVPVVDWNLQDPISVDLARAFRERGENAGRAGGSGGRGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUW5</accession>
    <name>A0A3N6MUW5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89202">
        <property type="protein sequence ID" value="RQG89202"/>
        <property type="gene ID" value="EA462_12615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="691" mass="75623" checksum="8595DFD2F5CCB640" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0M1</accession>
    <name>A0A3N6N0M1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91452">
        <property type="protein sequence ID" value="RQG91452"/>
        <property type="gene ID" value="EA462_05665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="155"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="366" mass="38004" checksum="23C6BDCB89BC3CC2" modified="2019-02-13" version="1">MGSDFDLVEFHADAVAIPSHEDVTEMRDFLLETLSDAGMAPEVDEFGNVLASRGRGDDDGTHVVLNTHIDTVPPHVSYDRDEGSDVVRGRGACDAKGPLASLLAAFLRVEPSDGRLTLAITPDEETLMTGAAGLAERLSADGYVVGEPTGLDVCVGARGQCEGTITIEGEGGHAASVPAATNPVAGLAAVLEALERYDDASGSGDTDVLGGPKLTPTGLEGGGAPNRVPGRCRLTFDRRTVPPETSESFRRDLQAYLEERVAGARTISVDLIRPDTPFPKAFVTDEDDELVRTLRAASGGDVRPFGAATEAGFFAATAPTVVFGPGVLADEDGAVAHAEREYVAVSALEAAAEALEDALSTLVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0W5</accession>
    <name>A0A3N6N0W5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91572">
        <property type="protein sequence ID" value="RQG91572"/>
        <property type="gene ID" value="EA462_06355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="328" mass="36672" checksum="3D8F7B64B10AE7A5" modified="2019-02-13" version="1">MNYRALGSTGRAVSEVGLGTWNIGGDWGEVSDETGREVVRSAIESGITFIDTADVYGDGRSERHIGHVLEERDAEDVFVATKAGRRLEPHDAEGYEYDRLSPFVDRSREYLGRGTLDLLQLHCPPTEAYYQPSTFHAVERLVDEGKIAHAGVSVERVEEALKAIEYDVVETIQLIFNPFRQRPREQFFDRARAEDVGVIVRVPYASGLLTGALERDQTFPENDHRNFNRQGEAFDVGETFAGIPYESGHDAVEALDPHVPEGLSLAELTLRWILDHEAVSTVIPGTTSPEHVRSNAAVSGSDPLSNRVRGAVRDVYEEHVFDHVHHRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3V6</accession>
    <name>A0A3N6N3V6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_00980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92832">
        <property type="protein sequence ID" value="RQG92832"/>
        <property type="gene ID" value="EA462_00980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="125"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="336" mass="38419" checksum="0B53E0CD1C39ECAC" modified="2019-02-13" version="1">MNQPSMTDSFRVPDDYAREYLAHAADLKLSTSSTDTYESHLRGYVVFLHDGEISVLDAAFTDVIEFVEECVRRGNRQSTIEGKVATISELYKYIRLRTEVGDELSLEPLRLDDIDVSRYRTPEPIEREALSREELRRLFDAFDSYRNRLMAVVAVETGLRNSDLRELRIADLDFDNLEIHVLNPKGSDPYDVPMSEELSYELDFWLRHHRAGYASADKSPYVFPSQCGLKLETNGSLNQIIRDAADRAGLQEVIGESRISKKQGTATEPEDETRQWHRVTPHTLRHSFITLLADAGVDLSYRQLVANHASAETTRGYTHTADDRFGEIREIFVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N468</accession>
    <name>A0A3N6N468_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amino acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92962">
        <property type="protein sequence ID" value="RQG92962"/>
        <property type="gene ID" value="EA462_01735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014424">
        <property type="entry name" value="UCP004897_ACT"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004897">
        <property type="entry name" value="UCP004897_ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="167" mass="18515" checksum="1C84152DE5C36342" modified="2019-02-13" version="1">MFDEIMEKFEGSPSQQAVIRLLLERGFSVNDDGRVVSGGIEIPNTGIAREIDVDRRVVDSTTDVILADPELRRIFQNISQVPSLMDLAPVLDLTVLSIAVADPEREGIVAGVTGTLADNDISIRQAISEDPEFTDEPKLYLITDHNLPGDVITQIRDLEYVRKIEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUY4</accession>
    <name>A0A3N6NUY4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87050">
        <property type="protein sequence ID" value="RQG87050"/>
        <property type="gene ID" value="EA462_15545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="242" mass="27265" checksum="9DFD6483E85116F9" modified="2019-02-13" version="1">MRHRVFNEDGDEELVFVMGWGNRWTHENVSWLLGKLTESGYRVHAFELPTNVEDFKADWLEPVAEYVLDLEGYQLLGHSAGALIGQALDGADNHVYLSPWWGYGSKFPDPMVLDAVATLPTTVPCLPVGELNETHLGERATDHQIATMPRWVSPAFVRETRHAHQELLTIDHDAVVFCSLRDPISDLRPIGERVPSEHVVLYDGGHELFSSARRDWYVDLVLDALENGSDAAEQRTVVPLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NV37</accession>
    <name>A0A3N6NV37_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87130">
        <property type="protein sequence ID" value="RQG87130"/>
        <property type="gene ID" value="EA462_15245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="212" mass="22255" checksum="CF3ED6567E0CE7D6" modified="2019-02-13" version="1">MGVSFDLFGTLVTADRPVDPAEAVAAELEARDVSVPDDWSQAYAERHVDAPVGAEVPLPAHVSHALASRGVAWTENAVRRAVVAAFDPAVETAPGALESIEAARARGPVAICSNCSVPELVSRTIVRAAFDRDDFDAIVTSVGCGWRKPAPEIFELTADELGVAPEELKHVGDDPRTDGGVERIGGTAVVLEDSPLESVPDRLAHTSGGTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVZ0</accession>
    <name>A0A3N6NVZ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88082">
        <property type="protein sequence ID" value="RQG88082"/>
        <property type="gene ID" value="EA462_14635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="90"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="375" mass="40328" checksum="63D872BAF8CFF191" modified="2019-02-13" version="1">MKRLLLIVLVAAMLVLAGCADGAITEDDGTTVEADDNFEDADSNDADDDTTTDDDETDTEETGESEAGEPDPGDPDVDGELEIHHIDVGQADATLLIEPSGETILIDSGDWRQGGSDVIEYLGDQDIDRIDHLVATHGHADHIGGHDAIIEHYETERDGIGVAYDSGIAHTSQTYERYLDAIEEHDVELLVVEEGDHVEFGDATVDVLNPPAGNSGSDLHYNSVALSIEFGEFSYLTTGDAEADAEQRMVDEHGERLETDAYQAGHHGSTTSSTTPFMDQATPEVAIISSAYDSQYGHPHDEVLEDYADRGIETYWTAVHGDVALTTDGSDVELETEHEFSTDAGDLLEEKPADDDDTQASLTHPIDVATTPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYB3</accession>
    <name>A0A3N6NYB3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_07205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89799">
        <property type="protein sequence ID" value="RQG89799"/>
        <property type="gene ID" value="EA462_07205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="118"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="345" mass="39972" checksum="1F937190BBD49B55" modified="2019-02-13" version="1">MATEATTEDVDDPIVYFLDDQRYHGKSDRTIEAYERVLRGFEAFVSEEFSVESLPDATRRECMAWVHSLRGQYEPSTVATYASYLNRFYDYMNRIGMFEANPMALVMEEMSESIDSDPTRRDISIDEMRSFVDTITHPLERAIVLTLLKTGMRVGELCNLDLRDLTVDCDELELQWDARVELDHRPSSVFVSSDPARGTEINGDERTASNKRKRDTVIPVDDELRSVLVAWLAIRPDPISPARPLFVDTRNSWGERITPSDVRYVVEKHGREFGWYRTGGGTTENVTPHYFRHFFTTHLRDRTGDRGIVQYLRGDVASEVIDTYTHDWGDRVRTTYLEYIYSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYI0</accession>
    <name>A0A3N6NYI0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF309 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89889">
        <property type="protein sequence ID" value="RQG89889"/>
        <property type="gene ID" value="EA462_07715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34796">
        <property type="entry name" value="PTHR34796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="162" mass="18453" checksum="9950C9088E6C9ED9" modified="2019-02-13" version="1">MDDHTRDPSVDPPPTGDPTGWLEAKGRWEHATLRRAVVHGVRLFNSGAYHESHDCFELEWYNYGRGTTESAFLHGMVQVAAGAYKRFDFEDDDGMRSLFETALQYLQGTPRDYYGVDVLQVRTVLTNAINEPGRIDGWDIPLDGERPVARPDDYEYLDELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYP9</accession>
    <name>A0A3N6NYP9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arsenic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_17135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86192">
        <property type="protein sequence ID" value="RQG86192"/>
        <property type="gene ID" value="EA462_17135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="331" mass="35601" checksum="2247C79D10E1903A" modified="2019-02-13" version="1">MNVLERYQTVVVVLAIGGGVLVGQLAWVPAVAERLILPFLLGMLFGTFVQVPLTGLRNAVANRRVVGSSLVMNFVWNPLFAIGLGYVFLREYPALWVGLLMLMVTPCTDWYLIFTDIADGDVALATSLLPYNLLLQLVLLPVYLSLFAGELVSLPLKTLLESVALVLVVPLVLAATGRVTLPKLLGEASFRRTLVPALGQAQILFLALAIAAMFASQGEVILENPGVLAVLAVPVIAFYAINFALGLGIGRVAAFSYEETVCFNCTILSRNSPVALAIAVVAFPHEPLIALALVIGPLLELPLLSVVSHLFLNLRERGLWKSTTSHSGEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ21</accession>
    <name>A0A3N6NZ21_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="9">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lpdA</name>
        <name evidence="12" type="ORF">EA462_16505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86736">
        <property type="protein sequence ID" value="RQG86736"/>
        <property type="gene ID" value="EA462_16505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="11"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="349"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG86736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="471" mass="49384" checksum="B3337EC78EF41698" modified="2019-02-13" version="1">MTSESGSSDTDVVVIGAGPGGYVAAIRAAQHGRDVTLVEKNAYGGTCLNVGCIPSKALITATDIAYDAGQAEEMGVYAEAAVDLKEMVEWKDGIVDRLTNGVEKLSSARGVTLVEGTASFVNERTLEIETGGERDRLSFDHAIIATGSRPIELPGMAFDGETVLSSTHALALERVPQRLVVVGAGYIGMELSTVFAKLGTDVTVVEMLGGVLPGYDDEISNTIRSRAEKLGITFRFGEGASDATQTPNGVRVTTENEGEESFEYDADHVVVAVGREPVTDTLALEKIGIEPDDRGFIRTDEQGRTECDHAFAIGDVTGEPMLAHAASKAGHVVADVVAGETTTLDEFVVPAAVFTDPEIGSVGMTADEATERGYEPVVGRMPLNASGRALTLDEPDGFVRIVADGDTETILGAQIVGPEASELIAELALAIDLEATLADLATTVHTHPTLSEAVMEAAANARGEAIHTLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P092</accession>
    <name>A0A3N6P092_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PQQ_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87828">
        <property type="protein sequence ID" value="RQG87828"/>
        <property type="gene ID" value="EA462_13240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PQQ_3" evidence="2">
        <location>
            <begin position="387"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="424" mass="45842" checksum="507F92633F73F1D0" modified="2019-02-13" version="1">MAEITRRALLQSVPISVAGLSGCVARSDGSHPVSEPPTDWPSFRLDQRNTGYAKGAQEVSDEPSVEWTFETGDDVWGSPVVVDGTVYVGSADNYLYALDASSGEESWRFQTGHRVEGSPAVGDGTVYVGSYDQSIYALDAATGEKRWEYEANGLIRGSPTVTDQAVYIGVGCFNLACEWYATEDSESEEPADDEPPEVGWIYSLDPETGETNWRYEVGSEAVSTPAVNDGTVYVGSSDEYLYAIDAATGEEKWTYEAADWIWSSPAVAFGTVYVGDFDGNVVAVDESTGEEQWTYNTFGAYLSSSPAVDDDTVYIGVVPANYPQGGERNDAEVVAIDRRNGGERWSFETDVLEIGSSPVVTDERVYIGSHSPVESEPTGVHALTTDGDERWLFEVGERGVGSSPALVDGVLYFGGVDNRVYALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0N3</accession>
    <name>A0A3N6P0N3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase GatCAB subunit A</fullName>
            <ecNumber evidence="3">6.3.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gatA</name>
        <name evidence="3" type="ORF">EA462_14615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88078">
        <property type="protein sequence ID" value="RQG88078"/>
        <property type="gene ID" value="EA462_14615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="482" mass="50560" checksum="3BCDB4B0195973EF" modified="2019-02-13" version="1">MFENYVRDVATRLGIDLDEDNVTTYAKQVDELTTQFDRSAVDPSSNRPAVDVEPGTDAYNAIRYHCRVTNDEMTTRSGDGRSLSGVDVVVKENIAVAGVPMHCGSEAVDFEPGYHATVVSRLIDAGVNVVGTTNMDELAYFTTGETCAFGPTDNPVVDGCVPGGSSSGSAAAVAGELVEAALGSDTGGSVRIPSSFCGIVGLKPTHRSVPRFGFADLSPSLDQIGPIARTVETVAQMYDVLAGPDVRDRSTHASSPAKDATEGVGESVDGRCIAVIGEAMDEATTGVSDQVERAVETLEGTGVDTTDVSVPEYRTATAAMRMIAGSEFAALCTFEGHIPGSGTGHSESWRSEISTAIQSPDLGENVREQIVTASALNEYGLEQYVTAQEIAAEFTETIATLLEEYDALLTPTTPMTAPTFGSVTSPKDFTRTIANTAPFNLTGHPALTVPHGTVNGAPVGVQFVGARYDERTLMAFGSELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P132</accession>
    <name>A0A3N6P132_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L18e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl18e</name>
        <name evidence="5" type="ORF">EA462_04150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91189">
        <property type="protein sequence ID" value="RQG91189"/>
        <property type="gene ID" value="EA462_04150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00329">
        <property type="entry name" value="Ribosomal_L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_L18/L18-A/B/e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022947">
        <property type="entry name" value="Ribosomal_L18e_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="4">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="117" mass="12891" checksum="2508400644293AFF" modified="2019-02-13" version="1">MSSKTNPRLNDLIAELKSTSRKADADVWRDVADRLEKPRRTHAEVNLGRIERYAREEETVVVPGKVLGSGALQKNVTVAAVDFSSSAETKIDQVGDPVPLEQVLEENPDGANVRVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1X5</accession>
    <name>A0A3N6P1X5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_12135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89115">
        <property type="protein sequence ID" value="RQG89115"/>
        <property type="gene ID" value="EA462_12135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="55"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="4">
        <location>
            <begin position="419"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="588" mass="62157" checksum="C85051629E7C91B9" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3M3</accession>
    <name>A0A3N6P3M3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89915">
        <property type="protein sequence ID" value="RQG89915"/>
        <property type="gene ID" value="EA462_07850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="83" mass="9163" checksum="2BE73E93BDDF4DD4" modified="2019-02-13" version="1">MSDPENEQYRAKTDKILQHSRRFPSVEECRRTLPVNPANTRTGAGISQQPATENADATTGSIRITSSLRYGSGDLIVVLFGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3Z2</accession>
    <name>A0A3N6P3Z2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_08840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90095">
        <property type="protein sequence ID" value="RQG90095"/>
        <property type="gene ID" value="EA462_08840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="341" mass="35616" checksum="B56CF4B1988BAE74" modified="2019-02-13" version="1">MEAVVEATGVEKTYGETVALSGASLAVERGEVFALIGPNGAGKTTLVRALTGTTDLDSGTVRILETSPTTVDRNRLGALPQAFSPPDRLTARELLSYYGNLYATPRDPDDVLAAVGLSDAGGTAYENLSGGQQRRVCVGSTLVNDPDVLFLDEPTTGIDPAGRRTVWRLIEDLAATGTTVVLTTHDMAEAERLADRVGLLADGSLVARGPPAELVREYGGSSRVTIETSADPAAFDFLEYPVERPVRHRRGGPTSSASGAVVVSDVEATAVGSVVDELESHGIEYTGLSWAEPDLDDVYLELAAETERSRTGRPGTRSGGEPEGTDPADGDGGGTQRGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P570</accession>
    <name>A0A3N6P570_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiol-disulfide oxidoreductase DCC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93209">
        <property type="protein sequence ID" value="RQG93209"/>
        <property type="gene ID" value="EA462_03165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="138" mass="15399" checksum="4A5461A95AA91C9A" modified="2019-02-13" version="1">MSAEIPENGSIVLFDGVCNLCTGFVQFLIPRDPNGIFYFASLQSDVGERLLAEHGLSSHDLDSIVLIDGDDVYVKSAAVIRIAGLLGGIYALARPLRFLPRRLRDWGYDVVAANRYRLFGKKDQCMMPSDDVRSRFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P5B4</accession>
    <name>A0A3N6P5B4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication factor C small subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_00625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93279">
        <property type="protein sequence ID" value="RQG93279"/>
        <property type="gene ID" value="EA462_00625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="32"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG93279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="334" mass="37192" checksum="67020FB2F897C4B5" modified="2019-02-13" version="1">MDAPLWTDTHAPELAELPQDDAREYLTKAVEEPINLLLYGPPGSAKTAAARALAREAHADPDNDLIEINVADFFGRTKTEIKNDPRFEQFLVGRSSLSKRDMINHVLKESASYASVSGEYKTIVLDNAEDVREDFQQALRRIMEQHHRTTQFIIATRQPTKLIPPIRSRCFPVSFRSPTTAETVTVLERIVEAEGIEYDADGLEFVAGYADGNLREAILATQTTVEDEGELTMQAAYETIATVGLDDEVESMLEDAEAGEFTDARKTLDALLVDEGLDGEEVINEILEIARKRYQGAKLARVHRLAADVEFEMHEGSSDRIHVSHLLAELGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P5D7</accession>
    <name>A0A3N6P5D7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine biosynthesis protein LysX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysX</name>
        <name evidence="6" type="ORF">EA462_03005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimK family. LysX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93319">
        <property type="protein sequence ID" value="RQG93319"/>
        <property type="gene ID" value="EA462_03005"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011870">
        <property type="entry name" value="LysX_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02144">
        <property type="entry name" value="LysX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="94"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG93319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="301" mass="32806" checksum="BA596437110A353F" modified="2019-02-13" version="1">MNVGILYSRIRKDEKLLLNELRERDHEIEKIDVRKQAFDIGAVPEELADLDIVVDRCLATSRSLYATQFLEAYGIPVVNSHETAEICADKVKNSLALEEAGVPTPATKVAFTKETAMDAIESFGYPCVLKPVVGSWGRLMAKIDSPDAAEAILEHKATLGHYEHKVFYVQEFVEKPGRDIRVLAADGEPIAGMVRSSDHWITNAAKGAETDVFEPDGEARELVAQASDAVGGGLLGIDLMETADIPESEPESGQRYTVHEVNHTVEFKALDGAVDTDVAGTVVDWLEEKAAATNDDLEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P606</accession>
    <name>A0A3N6P606_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91135">
        <property type="protein sequence ID" value="RQG91135"/>
        <property type="gene ID" value="EA462_03825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="PTHR11786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="247" mass="27791" checksum="D348739A8621DD89" modified="2019-02-13" version="1">MDEKRYLGRIGVEIDRGPKTEFDRLVELQRRHLYTVPFTNWFVLENDGTTMQSSTVVPRIVSGGGGLCYDLNGSFAWLLERLGFDVTFVSARPVRDDGSYGPAYDHLALLVDDHVVDVGFGAFARQPLPLGGTQRTDVSGTYRVFFDDDGYVVQKRAERDWEESYRFDTQPRTAGEFEEMTVHHSTSPESPFTDELLVSIATENGRKTLSGTTLTVTNGDTRERRDVQPGTVTDVLTDEFGLETRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6Q0</accession>
    <name>A0A3N6P6Q0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VanZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91535">
        <property type="protein sequence ID" value="RQG91535"/>
        <property type="gene ID" value="EA462_06130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="153" mass="16578" checksum="A891DDD7D9A34621" modified="2019-02-13" version="1">MTVRIPLLPPVVRWGLVAGVAAFIFYASILSPPPETVVDTAQPGFLPLDKWRHFVAYATLGYALAYATSTTWDGRRWRAFVLVVALTSLYGAGIELGQSVVPDRGFDPGDVVANALGATLVLFWFAIRPRLELTPVSQWISGSNSTESKGPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P738</accession>
    <name>A0A3N6P738_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium:calcium antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_06915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91735">
        <property type="protein sequence ID" value="RQG91735"/>
        <property type="gene ID" value="EA462_06915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="8"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="181"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="334" mass="34802" checksum="3638F6314F18466A" modified="2019-02-13" version="1">MLEVLTLLGLAVVATAVVWKGSAWLEEATNDLAAGYGVPSIVQGAVIAAVGSSMPELASVLLATLRHGEFELGVGAIVGSAVFNLLVIPGIAVLVGGRMDTNRDLVYKESLFYMLAVAALLLTFSLAVIYYPVEGDVLQGTVTRPLALFPLALYALYLFTQYLDATGSGVEPADVSRLGAWSWFAFGLVLIVVGVEGLVLAAIGLGEAFSTPAFLWGMIVVAAGSSVPDAFVSVAAARKGRASVSLANVLGSNTFDLLVAIPAGVLVAGSLSVSFTHVVPMMAFLILATVVFFAIVRTDMLLSKREAWTLLALYGVFVCWLVLESVGATNVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9K3</accession>
    <name>A0A3N6P9K3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92925">
        <property type="protein sequence ID" value="RQG92925"/>
        <property type="gene ID" value="EA462_01505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="100" mass="10791" checksum="30F2B5974D0A60AE" modified="2019-02-13" version="1">MSPAPSASTDSFPTQARYDSEDDELIFTVDAFPADIDDVAVAVGSRRLRIRIGPGSETGGVRYERIVTSPPRRTFTDEREAVYNNGVLTVTVGAAGGRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA10</accession>
    <name>A0A3N6PA10_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93165">
        <property type="protein sequence ID" value="RQG93165"/>
        <property type="gene ID" value="EA462_02885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="234" mass="27001" checksum="6CB45EA3669FB3EE" modified="2019-02-13" version="1">MQANFHTDTARLITDIRYEFDVDNFIETGTNVGETAEWASEYFDQVTTIEMDDELHAQATNERGHLDNIEFVKGKSQDELPTIVQELEEPAVFHLDAHCGGKWLDSAGDTSANAEFTECPVLDELEALSLSDHDHFVFIDDARVFTSPRREPFDMDDWPGIQEISHTVEALNEDYHILIYVDEIIIVPPFATEFVRERIRTYKTENRDQSNRFKRYVMNKVWQHASLSGPVQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHP0</accession>
    <name>A0A3N6LHP0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_16205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86684">
        <property type="protein sequence ID" value="RQG86684"/>
        <property type="gene ID" value="EA462_16205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="9"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG86684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="363" mass="39888" checksum="5AC3C4864A5939B9" modified="2019-02-13" version="1">MSDEPLVSLENAEVHFEAESGLFDFSDTDVVRAVDGVSLDIGEQDVVALVGESGCGKTTLGKTAIGLQRPTGGSVNYRGQDIWDAKDGSGDVDIPYNEIRRSLQIIHQDPGSSLNPNRKVLGTLEAPLKRWQPDMSSGDRRREIVKMLEAVGMTPAADYAGRYPHQLSGGEQQRIALIRALLMDPDLILADEAISALDVSLRVDMMDLMLELQGQFNTSFVFVSHDLANARYLASHAGGRIGVMYLGELIEVGPPEQIINDPQHPYTKVLRWATPDLRTVGEAEEPPVRNIDIPDPKNPPSGCRFHTRCPEARDACMGQSPESYDLGSGHRVRCFRSDDDHDYWSSPPVTDDEPTPRTPDPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHS2</accession>
    <name>A0A3N6LHS2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable molybdenum cofactor guanylyltransferase</fullName>
            <shortName evidence="4">MoCo guanylyltransferase</shortName>
            <ecNumber evidence="4">2.7.7.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP:molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Mo-MPT guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin-guanine dinucleotide synthase</fullName>
            <shortName evidence="4">MGD synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mobA</name>
        <name evidence="6" type="ORF">EA462_16985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide</text>
            <dbReference type="Rhea" id="RHEA:34243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:71310"/>
            <dbReference type="EC" id="2.7.7.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MobA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.77" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86165">
        <property type="protein sequence ID" value="RQG86165"/>
        <property type="gene ID" value="EA462_16985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00316">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="5">
        <location>
            <begin position="11"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="215" mass="23420" checksum="52F1BFB601A62E46" modified="2019-02-13" version="1">MDHHTSTERAGIVLAGGQSTRFDDTDKAVAELAGIPMIRRVLERLDPMVDELVVNCRGEQVASIRETLRDGPGVTFAVDPVPDRGPMAGILVGLRETTATYAVVVACDMPLVDPAFVDYLFERARGCDGAVPQLEDQWFQTTQAVYRCEPMAAGCERALEDGDGRIVTALADLEYVVVEETEVREQASLETFENVNTRAELEGVADRLDGNSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHZ5</accession>
    <name>A0A3N6LHZ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86689">
        <property type="protein sequence ID" value="RQG86689"/>
        <property type="gene ID" value="EA462_16235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="75" mass="8523" checksum="CB56CC0BCA6355CF" modified="2019-02-13" version="1">MSARTSFWSVINTYRPILSTFFAILLVLFVLNTFAFVSIDRTAETFVIVLLNFGILGGLLVATGLTLWRCRQHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI41</accession>
    <name>A0A3N6LI41_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86944">
        <property type="protein sequence ID" value="RQG86944"/>
        <property type="gene ID" value="EA462_14905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="87" mass="9785" checksum="B49B02A019AE22AF" modified="2019-02-13" version="1">MLALTLEEFMVELNEGSIKNVGPTNKSATVKLFDVDSASAREFGDKRVKLVFEDDEDNEIQVSLFPEEVRSLADDIDELEEESAVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI43</accession>
    <name>A0A3N6LI43_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Globin-coupled sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86769">
        <property type="protein sequence ID" value="RQG86769"/>
        <property type="gene ID" value="EA462_16680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01068">
        <property type="entry name" value="globin_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039379">
        <property type="entry name" value="Protoglobin_sensor_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="263"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="306"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="404"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="505"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="541" mass="58817" checksum="8E12A5ACAE7E27D3" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI83</accession>
    <name>A0A3N6LI83_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87024">
        <property type="protein sequence ID" value="RQG87024"/>
        <property type="gene ID" value="EA462_15390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="539" mass="61246" checksum="72013C429A0002F8" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJJ1</accession>
    <name>A0A3N6LJJ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88873">
        <property type="protein sequence ID" value="RQG88873"/>
        <property type="gene ID" value="EA462_10775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="145" mass="16733" checksum="440E0039C768E731" modified="2019-02-13" version="1">MGLPGTIDSSVYEGLKDVLQRYPVITAVAYEPDRIVKQFLRARVDPSRLVPPSGPEPPTLDIEWRFLENESYYRIHYADSNAGFNCGWHRDDDHPELGPVHFQFDHPVTGEREPVHFEQCVPTEILWTVLDRLFEERIPSLTSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJT0</accession>
    <name>A0A3N6LJT0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2339 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89013">
        <property type="protein sequence ID" value="RQG89013"/>
        <property type="gene ID" value="EA462_11555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019286">
        <property type="entry name" value="DUF2339_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38434">
        <property type="entry name" value="PTHR38434"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10101">
        <property type="entry name" value="DUF2339"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="590"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="625" mass="64605" checksum="D7CFE36ADD6F9EC0" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK10</accession>
    <name>A0A3N6LK10_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88908">
        <property type="protein sequence ID" value="RQG88908"/>
        <property type="gene ID" value="EA462_10970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="325" mass="36097" checksum="815BF157F5252041" modified="2019-02-13" version="1">MSKDNPLPRRIVLAAAGASATAGLTSVAAARDEDQQRTPDEIGSATRHLTVEIERYDDRSPAVVVPDQFETLADDAQSTINIAIENGRTIRYERPWVRGTGFVVDDEYYQYDVSFSGRETRETPVLVAESVDGKELETDSVTPVDEFTSAAWEAIHGAIGRERYLHLLETDPDTSVDDAKPRQRGYVFGSSENVPTQLADVDFPHYVQDETGDYHRLFLRPMQASVEVYDVRTESVAKTAAEFDEWFATEQLAVDDQLSLLSAQEEEVLMAASEGGITEKGEPNEAVAQFLKRINVDPTSTLDDRRWARIGSELLFIDVTRGVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKB7</accession>
    <name>A0A3N6LKB7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimI</name>
        <name evidence="2" type="ORF">EA462_12670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89213">
        <property type="protein sequence ID" value="RQG89213"/>
        <property type="gene ID" value="EA462_12670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="158" mass="17716" checksum="4F9CDC41E2D57D30" modified="2019-02-13" version="1">MTTDASPDRKRDVSIRRAERVDLLAVVRIEDESFSQPWPYDAFDRFLGDPGFLVAEHGGEIAGYVVADVSHRFGRRLGHVKDIAVHPDRRGAGVGSTLLSRVTAVLAAQGADSIRLEVRRSNDDAKRLYRQFGFEPLRRVSGYYDDGEDAIVMVRKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLJ7</accession>
    <name>A0A3N6LLJ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88010">
        <property type="protein sequence ID" value="RQG88010"/>
        <property type="gene ID" value="EA462_14225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="74" mass="8206" checksum="63CECAE7FD9F84AD" modified="2019-02-13" version="1">MGEFTARFPRRSRLSFTPSTLAIGSTGKNWSANSAPVTLEFQRLDAFSLVPIPKSNGFVGRCDRARSARYLRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLL0</accession>
    <name>A0A3N6LLL0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88030">
        <property type="protein sequence ID" value="RQG88030"/>
        <property type="gene ID" value="EA462_14350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="141" mass="15082" checksum="E8623CD56DCF968D" modified="2019-02-13" version="1">MSTSILVPHDGSSHAQAALEYALETFPNARIVLFHAIDPFETTSGADQLPSLTEEWLDSQRSEANALFERARDGIDDRGATFETETDVGTPAQTIVAAVEQTKTDQIVLGSHGRGGATDSRMGTTAEIVVKRASVPVTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLN2</accession>
    <name>A0A3N6LLN2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89778">
        <property type="protein sequence ID" value="RQG89778"/>
        <property type="gene ID" value="EA462_07095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="63" mass="6995" checksum="E58CFC9E7ECA4DDE" modified="2019-02-13" version="1">MNGQKQTKPTTSSTVRETVKSVLFRSDSVTVIEECRRCGTTIETSCSDCPTCGCDDIVTYRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM11</accession>
    <name>A0A3N6LM11_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_08890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90103">
        <property type="protein sequence ID" value="RQG90103"/>
        <property type="gene ID" value="EA462_08890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="89" mass="10295" checksum="BDEABCCF7D905FA7" modified="2019-02-13" version="1">MSASETVRREADQRGTWEDVRDLPPSAKLVAKVLEYNDTMTQQQIADETLLPSRTVRYALNRLDEENVIDSRFSFSDARKRLYSLDIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM41</accession>
    <name>A0A3N6LM41_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siroheme decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_10460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ahb/Nir family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88817">
        <property type="protein sequence ID" value="RQG88817"/>
        <property type="gene ID" value="EA462_10460"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00263">
        <property type="reaction ID" value="UER00380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg2" evidence="7">
        <location>
            <begin position="73"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="AsnC_trans_reg2" evidence="7">
        <location>
            <begin position="261"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG88817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="378" mass="41843" checksum="C5B1C9A84CBDBDBD" modified="2019-02-13" version="1">MSADVDLTELERAVVNAYQGGFPVVERPFEPAAAAMCERGVDIDATELLETIRDLDDRGVLSRFGPLVNAQQIGGQATLVAMHAPEERFEEIVEAVNGHREVAHNYEREHPYLNVWFVVSVASADRVAAVLEEIEAETGQETYNLPKRREFRVEAKFYVDGPLSKAGEGDGNGRPKDDGSTGIDCSDLGPDVSPTTKSTLSPAERDLVLEVQDGIPLTETPYSDVAATIGTETDWVLETVKRFDLEGKIRRVGVVPNHYALGYTENGMTVWNVPDELVEEVGPAVASLPFVTHCYERPRHEGVWPYNFFAMTHGRTEAESDRRIAAVREAMTEYWDVTDEDWDSLFSTQILKKTGIRLAERADANTESAGSGANERPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM49</accession>
    <name>A0A3N6LM49_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90048">
        <property type="protein sequence ID" value="RQG90048"/>
        <property type="gene ID" value="EA462_08590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="173" mass="18225" checksum="12DCD1D63E2C7CCB" modified="2019-02-13" version="1">MQLEQQTGETDWNGTVPNAFDLRILGFVGVIAALAASLNVPYGGIAFALVAFGILAGGGLVVHALGQRKLRRITDGLVERWVEAGGEIESVTRSSGGMRTEWTIRTTAGTVTIGGVAVVPIARLSVEWHGVSDSMDAADAEANLDRLADSLFEEIFEIGSETDATGLRTIPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMH1</accession>
    <name>A0A3N6LMH1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ferredoxin--nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_11520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89007">
        <property type="protein sequence ID" value="RQG89007"/>
        <property type="gene ID" value="EA462_11520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="54"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="138"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="327"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="405"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="587" mass="65499" checksum="85BC664BCF39A593" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMK4</accession>
    <name>A0A3N6LMK4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">V-type ATP synthase subunit C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">V-ATPase subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpC</name>
        <name evidence="10" type="ORF">EA462_11810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89057">
        <property type="protein sequence ID" value="RQG89057"/>
        <property type="gene ID" value="EA462_11810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00314">
        <property type="entry name" value="ATP_synth_C_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014272">
        <property type="entry name" value="ATPase_V0-cplx_c_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_suC/d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02923">
        <property type="entry name" value="AhaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG89057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="354" mass="40245" checksum="4645037E196E01B5" modified="2019-02-13" version="1">MSVSASNPEYVNARVRSRRASLFADDEYRKLVRMGPSAIARFMEETEYEREINALGARFSGVDLIEYALNRNLAKHFDDLLDWSEGRLYDLISRYLRKFDVWNVKTIIRGIYTESDPEEIRTDLIRAGELEDRTIDQLLEVETVEDAIEVLSGTIFADSLTDAYEEFEQTGALVPLENALDREFYEHLLEDVGQPYGEPMEGPEALYVEFLQAEIDFRNLRNALRLARSGADLDPGAYYIEGGTLFSQSELSRLVGNEEELVDHIAENERYAGRLSGALDRLRDADSLIQFEHALDAALLEYSDTLSSIYPTSVSAVLSYILAKEREVENIRAIARGREVGLDESEIEEELVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMP2</accession>
    <name>A0A3N6LMP2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90348">
        <property type="protein sequence ID" value="RQG90348"/>
        <property type="gene ID" value="EA462_07320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="62" mass="6432" checksum="FB021A92D6AA5BCD" modified="2019-02-13" version="1">MTDDTDQEVDHDSGADVGHDLEAERTTAPMSEYSARSVAVGFLVLVLGALIAFGIPLATLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMW1</accession>
    <name>A0A3N6LMW1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89227">
        <property type="protein sequence ID" value="RQG89227"/>
        <property type="gene ID" value="EA462_12745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="313" mass="33977" checksum="E9FFAFAD3E45C885" modified="2019-02-13" version="1">MTCYTAYGLTIRSAFDLPELPISARGDSSVDVVIRFGDVDPVPSSVPGEGGRRIEADSSVCRLSYETIGTFLVEEGKRVLFDPSPAFERRPGERPPKVVRRLLQNEMMGVLLHQRNALVLHASAVSVEGTGAVFLGPRGAGKSTTAAAFHAAGRTILEDDVVGIRFEESQPTVLPGVPQLRLLPDAVDALGVTGTTQPETDTDSKKRYKHLDVAPEPIPLGACYLLEEADHLEFGRLEPPDRVFQLISRTYTGGMLGETDATGVNFRQCSTVAETVPFRVLRRPKTHRSLSEVVDLVVADLRSLEKAPITESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LND1</accession>
    <name>A0A3N6LND1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-quinone oxidoreductase subunit L</fullName>
            <ecNumber evidence="8">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_15875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87105">
        <property type="protein sequence ID" value="RQG87105"/>
        <property type="gene ID" value="EA462_15875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="7">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="144"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="678" mass="72359" checksum="9E89A30354EED4F1" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNY9</accession>
    <name>A0A3N6LNY9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-requiring protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87927">
        <property type="protein sequence ID" value="RQG87927"/>
        <property type="gene ID" value="EA462_13780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="227"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="411"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="572" mass="61074" checksum="7B98A21A0DC2AE05" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNZ2</accession>
    <name>A0A3N6LNZ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91123">
        <property type="protein sequence ID" value="RQG91123"/>
        <property type="gene ID" value="EA462_03765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="118" mass="12037" checksum="0F8D8FBFF4FF1B72" modified="2019-02-13" version="1">MTEQVDVQELVIGVGTVLAFVLYGYGTFLRETILGVAATDLAVGAFAGTFLVVAVLHGAYGRRDFAVAHAAAGAGLVFVAAASSGPEVLVGILLLVAGGSYVAVATMRARRDRRAVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP17</accession>
    <name>A0A3N6LP17_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91153">
        <property type="protein sequence ID" value="RQG91153"/>
        <property type="gene ID" value="EA462_03930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="136" mass="15779" checksum="4DFF6D2FDFC4DA80" modified="2019-02-13" version="1">MTIRTLADESERDAAVAILRQLWSDADPEDILEWTENDDYHLFGRFEDDELVGVAGVLVRDVLHHACHAWLYDLVVDEPRRGEGHGSALIEFVEEWAADNDCEYVALASPLEKADVHQYYEDREYERWGYVIEKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP75</accession>
    <name>A0A3N6LP75_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91218">
        <property type="protein sequence ID" value="RQG91218"/>
        <property type="gene ID" value="EA462_04300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="451" mass="47369" checksum="F4995F018CFDAF12" modified="2019-02-13" version="1">MNQDRRQFWALYFTRFAEGFGFITLVTLLPYYINTLQPTDTTVLGLTISAGLIVGLYTTGFTFAQTVAVIPLAWAGDRFDKRTVLLAVLGAGAGVYALFPVVDSSASFILIRALQGVIITGAGLMSLSLVGQIAATGTRANFIGKSNAAYFAASIVGSLSAGALYEAFGFGPIFAIIVCITIVAWLAVGRYLEADETRVYGFPFSELALNSRILTLSSFRLQYAFSVTLVRTWIPIFAGVSAAQGGLAYGGLAVALTVVAEKFTNMCCQPFTGRLSDGYGRALFIFAGGGAYGLIALGVPFSSAIGAALSLPSSIVVSLPDVLVGASLPAVVSAETIPAQLTLLGDVSPAFFPLIALSGLLGIADSFREPASMALFADEGTEEGGVAASFGIRDLVWRPGSVIAPLLGGWLMYEVGMESVFFVGGAFALTGAISFLIILIWLHGRRALIQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPE1</accession>
    <name>A0A3N6LPE1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent carboxylate-amine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_04900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91323">
        <property type="protein sequence ID" value="RQG91323"/>
        <property type="gene ID" value="EA462_04900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="122"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="417" mass="45637" checksum="9F56D3E060DF52DE" modified="2019-02-13" version="1">MDSDRPTALVLDGDYDTSLVIARELTEDLEATIVGIGTTRQSRLLRSTYCDYAAVVPPPEESTYADALLAVITESRPDIVLPVGYESASSLDAIRSDVPAGVSVCLPPSESFRTAADKRATLETGHKLGIDTPTEYTALVSDLDADGRPSVSDRLPFPVFLKARTENGAATTAPVDDAADFWSTYDRIRASAPENEVLIQEYVDGSRSTYGCGVLCFDNDVELVCTHEELRSVPRHGGSGTHLQLLDEPRFERDAIRLLRKIGWHGIALVEFKRRSDGTFVLMEINPKFWASYALASRFGYRFASTIVAEHLGLEARSLTETPETSGEMVFPLRELKYHLENLDEASLSKYVKTVFGPDAAWDVDPRDLGAWLTPPPDVAQKVTSRRSSENGIGTTATQNSNGESQSKSSSRGETYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPH0</accession>
    <name>A0A3N6LPH0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90037">
        <property type="protein sequence ID" value="RQG90037"/>
        <property type="gene ID" value="EA462_08525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="358" mass="40504" checksum="69EA07CF24C4FED0" modified="2019-02-13" version="1">MTTNENKDQFRPDDHENDHFLLTTVVGSYPKPKWLNRAKELYQDPDHDFDDDDYQEAKDDAARLITNEHERAGLDVVVDGEMRRNEMVEFFAHRIEGYEFNGPVKVWGHNYFDKPSVVSDVEYDESWLVDEYEFTAAATDRPVKVPITGPYTLASWSFNEAYEDDAELAYDLADLVNEEIEKLVEAGARYIQIDEPALATTPDDHAIVGEALEHIVADIPEDVRIGLHVCYGDYSRIYPEILEFPVDEFDLELANGDYDQLDVFKDPEFTKDLALGVTDVHVGEAESVEQIERNILKGLEVVPPEQLVLSPDCGVKLLDREVAYGKMANMVEAARNVEAKLDAGEIDVERGAPTPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPI8</accession>
    <name>A0A3N6LPI8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribose 1,5-bisphosphate isomerase</fullName>
            <shortName evidence="3">R15P isomerase</shortName>
            <shortName evidence="3">R15Pi</shortName>
            <ecNumber evidence="3">5.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribulose 1,5-bisphosphate synthase</fullName>
            <shortName evidence="3">RuBP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_05320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate</text>
            <dbReference type="Rhea" id="RHEA:32243"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:68688"/>
            <dbReference type="EC" id="5.3.1.29"/>
        </reaction>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Reaction proceeds via a cis-phosphoenolate intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.29" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91393">
        <property type="protein sequence ID" value="RQG91393"/>
        <property type="gene ID" value="EA462_05320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043917">
        <property type="term" value="F:ribose 1,5-bisphosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02230">
        <property type="entry name" value="R15P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005250">
        <property type="entry name" value="Ribulose_e2b2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00511">
        <property type="entry name" value="ribulose_e2b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="212"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="326" mass="34972" checksum="B86A25A1F4521F57" modified="2019-02-13" version="1">MGNEAPAVDPVVESTAADIAAMRIRGAAAIADAAAAALAIQAERSDAVTPGAFRTQLRVAARTLYETRPTAVSLPNALRYVLRGTDGDSVDELRSSTIDRAETFREDLEDAQTTLGKIGSNRLRDGDVVMTHCHSTDALACIEAALDDGKRIEAIVTETRPRKQGHITARELREWGVPVTLIVDNAARRYLDDADHVLVGADSIAADGGVINKIGTSGLAVNARERGVPVMVAAQTIKLHPGTMTGHTVAIEMRDETEVLTSSERSEITDLEDGDDGFTVENPAFDVTPPRHVDAIVTEHGQFPPESVVTLMRELFGETTTEPWET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPL4</accession>
    <name>A0A3N6LPL4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91413">
        <property type="protein sequence ID" value="RQG91413"/>
        <property type="gene ID" value="EA462_05425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="10"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="187" mass="20997" checksum="DB4B57A6945F980C" modified="2019-02-13" version="1">MVLKESDTVLDEGDAPPAFELEGTDERTYTLVDFANDEALLLVFTCNHCPYAKAKFDLMNELAAEYDDVSVVGINPNDATEKPDDSIERMRDLVDDGTIAFDVYLRDESQSVAREYGAVCTPDPFLFANDDGQFRLVYQGRLDDALNPDDEPTRYHVREAIDAILAGENVDLEWQPSQGCSIKWSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPU9</accession>
    <name>A0A3N6LPU9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_06255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91558">
        <property type="protein sequence ID" value="RQG91558"/>
        <property type="gene ID" value="EA462_06255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="782"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="7">
        <location>
            <begin position="71"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="824" mass="87122" checksum="527722C9AC35CB9D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ58</accession>
    <name>A0A3N6LQ58_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91708">
        <property type="protein sequence ID" value="RQG91708"/>
        <property type="gene ID" value="EA462_04935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="95" mass="11397" checksum="1BBEEEC3BBD3248E" modified="2019-02-13" version="1">MKTTAVETVFEGSNGRYYTGWQIRRNLENGHWKLCIRQRTPVRYLVETGADVLLLLTSIDLERLPNWLEVRVRGMATRVVDRRRSIPHRRRYRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ62</accession>
    <name>A0A3N6LQ62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligoendopeptidase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pepF</name>
        <name evidence="9" type="ORF">EA462_11895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89074">
        <property type="protein sequence ID" value="RQG89074"/>
        <property type="gene ID" value="EA462_11895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004438">
        <property type="entry name" value="Peptidase_M3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00181">
        <property type="entry name" value="pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="114"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="204"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="597" mass="68340" checksum="205ECB8BF6D2A027" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS31</accession>
    <name>A0A3N6LS31_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps7</name>
        <name evidence="7" type="ORF">EA462_00030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92663">
        <property type="protein sequence ID" value="RQG92663"/>
        <property type="gene ID" value="EA462_00030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_A">
        <property type="entry name" value="Ribosomal_S7_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_S5/S7_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026018">
        <property type="entry name" value="Ribosomal_S7_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="6">
        <location>
            <begin position="55"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="202" mass="22140" checksum="8C27402B0014A501" modified="2019-02-13" version="1">MAAEDQPDPDAPAGGADVGAKLFGTWEIDEIAYDDPSTERYISVTPVAHTAGRHASKQFQKSQISIVERLINRLMQTEENTGKKQMTLNNVRESFEIIHERTEENPVQVLVTAVENAAPREETVRLKYGGISVPKAVDVAPQRRVDQSLKFIAEGVQNASFKSVTSVPEAIASQLTGAANYDVQTYAISQKEEKERVAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSA7</accession>
    <name>A0A3N6LSA7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantoate kinase</fullName>
            <shortName evidence="1">PoK</shortName>
            <ecNumber evidence="1">2.7.1.169</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28246"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. PoK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.169" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90144">
        <property type="protein sequence ID" value="RQG90144"/>
        <property type="gene ID" value="EA462_09140"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02223">
        <property type="entry name" value="Pantoate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012043">
        <property type="entry name" value="PoK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42282">
        <property type="entry name" value="PTHR42282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016896">
        <property type="entry name" value="GHMP_arc_MJ0969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="2">
        <location>
            <begin position="83"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="280" mass="28764" checksum="E296C1A60A48EFF6" modified="2019-02-13" version="1">MREEATAFVPGHITGFFSAHTDTDPTKAGSRGAGVTLTDGVDVTVRRHAGANAADSSVVLDGESITVEPVSTVLETLGVSARVEAEADLPLGAGFGVSGALTLGTALAANRVFERNLSWNELVTIAHGAEVQAGTGLGDVVAQAYGGIPIRLEPGGPQVNRMDAIPERARVEYVSFGELSTEAVLAGDMEAVTAAGKQALSRVVEEPTLLSFIYASRVFAREAGLLTDRVKTTIDDVSDAGGQASMAMLGETVFAFGTGLSDAGYEPTACATHPAGAMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSN0</accession>
    <name>A0A3N6LSN0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_01770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92968">
        <property type="protein sequence ID" value="RQG92968"/>
        <property type="gene ID" value="EA462_01770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013702">
        <property type="entry name" value="FIST_domain_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08495">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00897">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01204">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIST" evidence="1">
        <location>
            <begin position="33"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="FIST_C" evidence="2">
        <location>
            <begin position="228"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="396" mass="42400" checksum="A935AB5E09222F91" modified="2019-02-13" version="1">MSTSVSTALVTDSEGNPGKRAATEAVAQLPGERVDFCQVFCPVEHDFERVLGGIRDVIGSDANLIGCSANGSFTQDAVGSGVAVGLVTSDTLSFYTGLGTGLRENVSRAVREAIGNLPEQVNDHPYAAAITLHDGLSGVGEKLALISQQKLGPEVSIAGGSAADDHQLEATYVFHDDEVVEDGVVMGLIGAQQRPVVAVEHGHEPLSEPVEVTRADGPIVHELDGDPAFEVWKDAVRETVSEEFDVRIDDLDASETLLQEILCEFEFGIDQGSQYKMRWPWIEDENGAMHFAVDIPDGTVLRVMHGRPDAQIESAGETVRRALQDAGDVTMAGGFIYDCACRGIVLGDEFETAVEEMARELSVPFVGFETYGEICMGPGQFSGYHNTTTVALLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSP4</accession>
    <name>A0A3N6LSP4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Potassium transporter Kef</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_06200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91547">
        <property type="protein sequence ID" value="RQG91547"/>
        <property type="gene ID" value="EA462_06200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="406"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="566" mass="61809" checksum="F7CC93C52957D3AA" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSR0</accession>
    <name>A0A3N6LSR0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91577">
        <property type="protein sequence ID" value="RQG91577"/>
        <property type="gene ID" value="EA462_06380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="76" mass="8313" checksum="4718AAF3FA156272" modified="2019-02-13" version="1">MVHAFIMVKTAAGKSEELLSSIRDLERVTSAHIVAGNYDIIAEVDADEVYHILEAVSTNMQGLEGVTETKTYIAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LST3</accession>
    <name>A0A3N6LST3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91617">
        <property type="protein sequence ID" value="RQG91617"/>
        <property type="gene ID" value="EA462_06615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="134" mass="15036" checksum="BF6146D401DD11A5" modified="2019-02-13" version="1">MASPQTTASERPPDACPVIESLEQIGSQWRLAVLHELLSGEQRFNELKRSTGANARTLSRVLDDLGEMGFVERRIEEDAPIATYYSLSPKGRSLEPVFGEIECWAGTWLENEPEEDRLESDANAGRLEDELKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LTB2</accession>
    <name>A0A3N6LTB2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93298">
        <property type="protein sequence ID" value="RQG93298"/>
        <property type="gene ID" value="EA462_01730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="182" mass="19209" checksum="7CB90C3F394786F0" modified="2019-02-13" version="1">MSEHEYNAASPGASRSLTDGVSVQETENQEGIDFSINGNAVSFSGDPEKPLLYVLRNDAGLNGPKFGCGVAQCGSCEVLVDGETVISCTTPVEDVAESEVTTTRGLGTSDDPHPVQEAFIEAQAAQCGYCIHGMIVEAAALLEENPDPSDEEIDDALADNLCRCGTHDEIRTAVNRAAEEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUD4</accession>
    <name>A0A3N6LUD4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrrolo-quinoline quinone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91174">
        <property type="protein sequence ID" value="RQG91174"/>
        <property type="gene ID" value="EA462_04055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PQQ_3" evidence="1">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="1">
        <location>
            <begin position="235"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="1">
        <location>
            <begin position="274"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="1">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="1">
        <location>
            <begin position="365"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="403" mass="42154" checksum="E8E25CF9AF4039D0" modified="2019-02-13" version="1">MRPVRDRRGFLRGATTACAVGLAGCLGGSNGDGSDDVEVDVDPGDPDASEDWPTFQFDAANTGRAPGQGPTGGVEARWSFPTEDPVYSSPAVVDGTAFVGTNGGTVYAVSTDDGDEEWRVTTGDSVTSSPAVVDGTVYVGSQDGTLSALSADDGEEVWQFRAGGMIAGSPTVVDGTVYVGSTDTVLYALSADDGEELGEFETDGSIQRAPAVTEDAVFVGSGDQSLYAIDRELDEQRWAVQTGDWIQSRPAVADGVVYVGSNDDHVYAIDADSGEIRWTFLTEGSVTASPAVLENVVYVGGFDSRIYALSPESAETEGEGPDDPATHYWSSSGFQQIRSSPAVVGDTLYVGNEDSHVYALSAVDGETRWRFSTDGGVASSPAVVDDTVYVGSEDGHLYALEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVU7</accession>
    <name>A0A3N6LVU7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="4">1.8.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrB</name>
        <name evidence="4" type="ORF">EA462_01410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92907">
        <property type="protein sequence ID" value="RQG92907"/>
        <property type="gene ID" value="EA462_01410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="3">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="134" mass="15134" checksum="FC205D37C5B9D05F" modified="2019-02-13" version="1">MSNPSETELPTTDEEWRTRLDDEEYRILRESGTEPPFSGEYVDHEDDGRYTCAGCGAELFDSETKFESGCGWPSFFDTDDDRIETRTDTSHGMRRTEVLCGTCGGHLGHVFDDGPEPTGKRYCINSVALEFDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LW07</accession>
    <name>A0A3N6LW07_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92987">
        <property type="protein sequence ID" value="RQG92987"/>
        <property type="gene ID" value="EA462_01875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="448" mass="48135" checksum="E7AC4A838339B4F4" modified="2019-02-13" version="1">MSDDASDESDGDSDCLERGLGTRSVHAGQRADPNTGAMAPPIYQTTSYVFEDADTAAARYALEDDGYIYSRISNPTVTTLEDRLASLEGGAGAVATGSGMAALDSAVLILAQAGDNVVCSTDTYGGTTAYFSKTATRRDIEPRFVPTLEYDAYEAAIDEDTAFVHVETVGNPSLVTPDFERVAAIAHDHGVPLVVDNTFATPALCRPLEHGADVVWESTTKWLHGSGTTVGGVLVDGGSFPWGDHGYDEIAGQNHAYHDVDFSRDFPEAPFAETARFRSLRSLGNQQSPFDAWQTLQGLESLPLRVDKHCENAAIVAAFLDDHDAVSWVTYPGLADHPTHDNASRYLEEYGGMIAFGLENGYEGGKRFCENVELAQFLANIGDAKTLVIHPASTTHGQLSPDEQEEAGVTPDLVRMSVGIEDPEDILADIDRAIEIATRTTTGEQPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LWN7</accession>
    <name>A0A3N6LWN7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93287">
        <property type="protein sequence ID" value="RQG93287"/>
        <property type="gene ID" value="EA462_01230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="226"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="484" mass="54257" checksum="D49C55D2D82F411C" modified="2019-02-13" version="1">MSDAALDVVEFLLTTSVYSDDRTLDENDLPPAFRRVFWTGGDGEDGTGDETGGTGTYSGISRPLSATNSTARQATGVDQPWEAVSELMFTERDEFSGTITLAQEEMAEQWFVERVDEDRLLENPTLAKHFESDPDAEFDVEVSHEEARSRNRPIQADRVWIDGLLEEYFDEDDDEDMLDLVDVRAPEEVDITLDDLVLTEGQESEIDKISKAIEHRDYLARIGLREIGKLLFVGPPGTGKTSTAQALARDMDLPFVEVKLSMITSQYLGETAKNVDKTFEVAKRLSPCILFIDEFDFVAKTRRSDEHAALKRAVNTLLKSIDNISLIEDDVLLIGATNHPDQLDDAAWRRFDEIINFPKPDYGMRADILRVITRTMDIQEFDPQLIAEITEGLTGSDLRMVLREAVLEALTEDRTTLTQEDLLNAVEEFEERDSLKNMDMIEGDHDALVAGGDLGKASDGGHDHDHSHGGHDHDHSHDGHDHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXB4</accession>
    <name>A0A3N6LXB4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86671">
        <property type="protein sequence ID" value="RQG86671"/>
        <property type="gene ID" value="EA462_16140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="97"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="308" mass="33662" checksum="D2E7F4BB706030EA" modified="2019-02-13" version="1">MIPTGLQLSSSATERLFDLLTKGVLGTLLLFALFPIYWMVISSFRTRTEITAADPQLLPFELAEIPAIVQDPVLLAEILHYENYVTMWGRFPVLDYFINSLIIASTTTVFALIVGCLGGYAFSKYRFPGKGAVGGALLGTQMIPGILILIPMFLLFVWIQDTFAIPLVDTYHGIIFVYTTFTIPVAIWMLRGFFDTIPDSVEEAARVDGCSRIQALVRVVLPMAAPGIAATGMFVFLVAFNEVLFASILASGDVTPFAIGIQSFETQTTAYWGEMMAASTVATAPVLLLFVLFQKPIVEGLTEGSVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXV5</accession>
    <name>A0A3N6LXV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_17295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86108">
        <property type="protein sequence ID" value="RQG86108"/>
        <property type="gene ID" value="EA462_17295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="73" mass="8040" checksum="5AE15B30B50017AD" modified="2019-02-13" version="1">MFSLVTDLFRTRSSGPLERAVDDSVPFIPLCFRPDVNSCYAGSTVDGWFDRCPLLRSLSFLDDTASETDSSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXW1</accession>
    <name>A0A3N6LXW1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000009">
        <property type="protein sequence ID" value="RQG86118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86118">
        <property type="protein sequence ID" value="RQG86118"/>
        <property type="gene ID" value="EA462_17285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="97" mass="10431" checksum="8E394094C861255B" modified="2019-02-13" version="1">MSPEPIGTTTAVALAVVKTLVLIVGSVITFFAYRAYRRTRQPALGYLATGFGIVTLGLVLAGMLYELLDLPLRTGLFLESLLMLAGFVVIAYSLYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXX4</accession>
    <name>A0A3N6LXX4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86931">
        <property type="protein sequence ID" value="RQG86931"/>
        <property type="gene ID" value="EA462_14835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="206" mass="22638" checksum="BE9D0BD62C75956D" modified="2019-02-13" version="1">MPDCDYCDASFTDEEAYLDHLASEHAADLGRIDRRRVERRGSLEGDGGSSPIVLYGLALAFGLIVIGAVGYVVTSGMADEGYVHEHGQLTVEVDDEVIDFEQQRYYQEELGGTFHFHPDDGNTWHMHPDRVDLEHAMADIEMPISEGAITIHGEAFDDDAPDTNVEITINDEPADLSEELHDGDQIRIAVETADGDGLPDAADEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY19</accession>
    <name>A0A3N6LY19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86981">
        <property type="protein sequence ID" value="RQG86981"/>
        <property type="gene ID" value="EA462_15125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="196"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="339" mass="36187" checksum="7FF9B06A4A456A71" modified="2019-02-13" version="1">MECTGTILRGRTFEPVEGRLIVGDDGRIDAIEEGSVDSTDIVVPAFVNAHTHIGDSIAKEAGRGLSLEELVAPPDGLKHRLLRTASREELVEGMRRSLQFMQRSGTAACLDFREGGVAGVEMLEEAASGLEIDALSFARGSTAAMRAGDGFGASGANDAAFDRERTATREAGKPFGIHAGEVDESDINPALDLDPEFLVHVVHPQPIHMERIADSQVPIVVCPRSNLVTDVGLSPYEELSERTTLALGTDNVMLNSPSMFREMAVLSKISDLPAPEILRMATINGAELAGLEYGSIEPGRPARVIVLDGDSDNLTGVRDPVRAVVRRAGVDDVRDVVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYE0</accession>
    <name>A0A3N6LYE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Class II fructose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86742">
        <property type="protein sequence ID" value="RQG86742"/>
        <property type="gene ID" value="EA462_16540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="333" mass="36762" checksum="8A1510ABA751D6FE" modified="2019-02-13" version="1">MTFYRGSELESVYQNALSDGFGLVASNIAEPNVLIGLMEGASRAESDLLLQASAGACRFAGNGDAEAGLNALGAYIDALAEGFDIGVFLNMDHQTDTEFIEFQMDEEIPSSVMIDASSESFEENVKISREVVRMATEKDADVLIEAELGQIKGAEDDLEVDNAFYTDPEQAVEFVDRTGCDLLAISVGTQHGVAKGKDLELRPDLAGEIRQTLRDHGLDTPLVLHGSSGVQPDQLRTMLRHGICKVNKDTRYQYEYTRTAMEYYERHRNSIVPPDADRDGRDTFFNETAWTPNKDHFDPRVGGRQIRERIAEVHAQLAAVSGSAGRSRYLETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYE7</accession>
    <name>A0A3N6LYE7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86752">
        <property type="protein sequence ID" value="RQG86752"/>
        <property type="gene ID" value="EA462_16590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="165" mass="17087" checksum="69881E686AACADCD" modified="2019-02-13" version="1">MGFSTSGAVLVILIGVLVAMSVIVPTVFNVGAATGEAFSTQSEQLRDQQNTAITIESFENVTDTDAEANATVNVTNAGASSLSVGKTDVVVNGEYYPVHGSDAETTIVDGETDRPSSDIWSSGSHLEVEIHDDDLDTVITGDGDRVRITTEHGIADAATITEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYJ7</accession>
    <name>A0A3N6LYJ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterio-opsin activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_01625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92944">
        <property type="protein sequence ID" value="RQG92944"/>
        <property type="gene ID" value="EA462_01625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAT" evidence="4">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="158"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG92944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="229" mass="25026" checksum="9E84E3D1BC06337D" modified="2019-02-13" version="1">MATLIDFVVSAEEFPFGELFTALPDVSVELDRVVPTNGALFPYVWISGGDHADIEAALEPSGATFVPQTVTLVDELEDRGSLYRVTWDPEPTGLIEIISDSGATMVSAVGARGQWTFTLRFDEHAEIGAFQNRCRTTDIHLSLSRLQPLGYAARDRELTPAQLEALELAYRCGYFDDSRRVTLDDLASEVGISRQSVAGRLRRGHRNLLAGLFSSSERTVGGVTSSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYQ6</accession>
    <name>A0A3N6LYQ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87803">
        <property type="protein sequence ID" value="RQG87803"/>
        <property type="gene ID" value="EA462_13095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="356" mass="39760" checksum="C6F13CFB3142A800" modified="2019-02-13" version="1">MDFTHPYEEVDWSNSEHHLAQFHVHEPRNELSADTARHEPDVALEGVPIDHIGKNDLSEASSPGVLIQKYRNAGYTVFSLTEHEYQVDGKKYKRVPYDEVDADLDKMSWPWSQWGVDADELGMVALQGGEIRGDVEGVEKLHDIVSLDNDLGHGKDQSVETVLGEVEDRGGITFLAHPSKYTATEDWELYIPVLESSDALLGLEVFNGDDRAPSRELWDKLLTHFGSDRPIWASGGDDYHARARERYDKRFNRSRTVILVPELSKQNVTDALRDGKSYVQYNGDAQAPFIESIESTENSITITAPSAHEITWIADGEAVATGETVVSETLDDPAYVRAELSGRGGSITATQPFYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ45</accession>
    <name>A0A3N6LZ45_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93164">
        <property type="protein sequence ID" value="RQG93164"/>
        <property type="gene ID" value="EA462_02880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="33"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="134" mass="14941" checksum="7291DC7E70B5E12E" modified="2019-02-13" version="1">MATEQTHQEIEEYLGQVPSWMETIAEPAGDHSWGLFRDLVLGETELSSREKGLVGLGVAAAIGCPYCTYFHKEEARLADVSDEELEETINVASNTRYFSTILHGNEVDQDDFVAETDEIVNYIQEQQEAAPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ60</accession>
    <name>A0A3N6LZ60_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysine biosynthesis protein LysW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lysW</name>
        <name evidence="1" type="ORF">EA462_03000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93184">
        <property type="protein sequence ID" value="RQG93184"/>
        <property type="gene ID" value="EA462_03000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005906">
        <property type="entry name" value="LysW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40393">
        <property type="entry name" value="PTHR40393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01206">
        <property type="entry name" value="lysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="54" mass="5906" checksum="EB89E6E87DE91F08" modified="2019-02-13" version="1">MTECVECGAEVSLHDDLEIGEIVDCTTCGAELEVVDTEPPVLERAPELEEDWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZB2</accession>
    <name>A0A3N6LZB2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93254">
        <property type="protein sequence ID" value="RQG93254"/>
        <property type="gene ID" value="EA462_03415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="59"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="231" mass="25698" checksum="3547C5535BA9D89E" modified="2019-02-13" version="1">MVNESPSSTADGRSTGAAYQNHLERSRTVWNRWSDYYAMSERDLEPMREAAMDDLALERGDRVLDIGCGPGVNLERLRDDVGETGTVVAVDYSPEMVAKARDRIERHGWKNVEVHLDDATTIDLEGRFDAAIATLSMSVMPDVRAAVENVHRLLVPGSPFVVFDIGGVPEGPARLANPFLRRFLRWYANWNPDGDVPGSLSAVFEESEIVDTYLVGTCYTVIARKHSPDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M041</accession>
    <name>A0A3N6M041_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV pilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88960">
        <property type="protein sequence ID" value="RQG88960"/>
        <property type="gene ID" value="EA462_11260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012859">
        <property type="entry name" value="Pilin_N_archaeal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07790">
        <property type="entry name" value="Pilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Pilin_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="142" mass="15048" checksum="41EC748CBA1BCA61" modified="2019-02-13" version="1">MIETVQESNRAVSSVVGIILVVAITVILAAVVAGIVYDVGESVNEEVQAGVSITVEHDPQYIDIQVTTLGSAEYVNITGDPFNHLEGGSSLEEEDFQELEVGESLRISENDLESDGESGTVAAVAVGGDRETLVTSQEYDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0A4</accession>
    <name>A0A3N6M0A4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87964">
        <property type="protein sequence ID" value="RQG87964"/>
        <property type="gene ID" value="EA462_13985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="148" mass="16305" checksum="FDF7C455F5E81DBD" modified="2019-02-13" version="1">MTGMKEGAGEDPFADDATTSNPDADPPSERDSSDGVTADTVEPTESTDANAGSSSPVGTSRSADQPQIRIPYKFRRDGVQDGRDRVPLFLHEETKGAERDVLRELEDRFDDDVSLTDLREALVKVGLEHLDEVELELEEWGYGMTFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0P6</accession>
    <name>A0A3N6M0P6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89210">
        <property type="protein sequence ID" value="RQG89210"/>
        <property type="gene ID" value="EA462_12655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="200" mass="21915" checksum="994ED72BA7E5E7AC" modified="2019-02-13" version="1">MTESTEWTLLEEVTEYETGWYDGGYDLLEQPDGTEKRYYWASLPPAVVVVARVDGDLVPSVDGAVKDSGDPVDGDRLLFVEQYRPPIRETHLELPAGIVEDGESYTTAAARELEEETGFRPSSTALLQEYAVATGVLRHDRGVVYAEDLGPGQRQLDSNEFLDVTTVPVAEALERARALPANDSTLSALLLAKEDGLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0R9</accession>
    <name>A0A3N6M0R9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="5">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glmS</name>
        <name evidence="9" type="ORF">EA462_12815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89240">
        <property type="protein sequence ID" value="RQG89240"/>
        <property type="gene ID" value="EA462_12815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 9" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="286"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="8">
        <location>
            <begin position="449"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="5">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="599" mass="63514" checksum="EBB19F8BCAEB3FAD" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M197</accession>
    <name>A0A3N6M197_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88851">
        <property type="protein sequence ID" value="RQG88851"/>
        <property type="gene ID" value="EA462_10650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="165" mass="18213" checksum="44BA671E81A29409" modified="2019-02-13" version="1">MELKAASVDWMEDVGNDPRLQVVVDEIPSRDKLRFEHEDGIWCGIKDGFVSYYAWSGDGNDGGYAGRCYTITMRDGTEVTLKGPWSSRAGCVNQRSFGPVVDVRITTDPSALERGHTFGTGSLTLEAAKQAIDLVDEDAHLERQLKYSNDEPVWVPVRDTGGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M302</accession>
    <name>A0A3N6M302_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_09495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90210">
        <property type="protein sequence ID" value="RQG90210"/>
        <property type="gene ID" value="EA462_09495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="307" mass="33429" checksum="8A929197D40438C7" modified="2019-02-13" version="1">MSAVATPLQNGEPGGDSGIVAGVLEESLGDATVAATVERLVLFVVAFLIVYAVGRFVVIPLLNRAFDRRDLDRHARRPLVKITKFGILFVALAAAFGAADFGNFLVSLAGIAAAGALAVGLAMQNVIRNFVAGVFIYVDKPFKIGDWIEWDDHAGVVEDISLRVTRVRTFDNELLTVPNSALTENVLKNPVDADTLRLKFVFGIGYDDDIERATEIIVEEGDRHPEIVDDPGPSVRLTELGDSDVGLQSRFWIETPSRADFVRIKGEYVTAVKERFDEEGIDIPYPVRTLEGDLAVENGIETAQVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M379</accession>
    <name>A0A3N6M379_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_16865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86143">
        <property type="protein sequence ID" value="RQG86143"/>
        <property type="gene ID" value="EA462_16865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="113"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="323" mass="35467" checksum="6372EAEF7DEEF37D" modified="2019-02-13" version="1">MANPETDVLVLRKGTHGMPIEQYVAALRERLPNGRVRLARTPAEEREEIRDASFVAGMVLEDDVLDAAEELEVFACAYAGTGHLPLERLAERGVTVTNASGVHGPNIGEHVLGAILRFARRFHVGARRQRRREWRHYQSHELEGSTVTIVGLGAIGNAVCDRLEPFGVETVGVRYSPEKGGPTDEVIGFETASVHDALARTDYLVLACPLTETTQGLIDQDAMMTIDPDAVIVNVARGPVIDTDALVGALRSNWIRGASLDVTDPEPLPEEHPLWTFDNVQITPHNAGHTPKYYDRLADIVAGNARLYVEDGLDADFENRVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4B2</accession>
    <name>A0A3N6M4B2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Probable cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">cobD</name>
        <name evidence="13" type="ORF">EA462_15235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Cell membrane</location>
            <topology evidence="3 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86997">
        <property type="protein sequence ID" value="RQG86997"/>
        <property type="gene ID" value="EA462_15235"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG86997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="346" mass="35541" checksum="B70BD9A457C41AB0" modified="2019-02-13" version="1">MALTTLALIGFAFSLDLLIGEPRTALHPVAWFGRLVDAVDREWADTDRGQRLIGVAIAAVLPLVPAAVAAGAVLAASRWIALLGAVVAGVVLFLTTSLRSLLELTEEVVTATGDDLETAHERIRGLVGRETSTLSPAEVRSGALESAAENLSDGLIATMLPFAVLAPISLPLAAGAAAWIKGVNTLDSMLGYPSKPIGTASARLDDLVMWIPARVTAASIAGAAANPTALRCARTWAREPASPNSGWPMATLACVLSVRLSKRGEYVLNPDADLPSVSDGDRAVTLVGMAAAVSVLIAAVLSVGVATVGTPPATAVVTSASEVLIRTIAAGLERAVVTNWPVVGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4M6</accession>
    <name>A0A3N6M4M6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase [glutamine-hydrolyzing] subunit A</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">guaAA</name>
        <name evidence="5" type="ORF">EA462_09390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90191">
        <property type="protein sequence ID" value="RQG90191"/>
        <property type="gene ID" value="EA462_09390"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01510">
        <property type="entry name" value="GMP_synthase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023686">
        <property type="entry name" value="GMP_synthase_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 3" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="184" mass="19996" checksum="7F3120FAD59FFC3B" modified="2019-02-13" version="1">MTKIVVVDNHGQFTHLERRALRDLGVETELIENDTPPADVDADGVVLSGGPEMDRIGNSPAYLEEDVPVLGICLGMQLIAEELGGRVESGEYGGYADVTVDIVDGDDPLTGSLHPQTRVWASHADEVTAVPDGFELTARSDVCDVEAMSDTDRDIYGVQWHPEVAHTEEGDEIFENFIGICESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4P2</accession>
    <name>A0A3N6M4P2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_15565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87137">
        <property type="protein sequence ID" value="RQG87137"/>
        <property type="gene ID" value="EA462_15565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="28832" checksum="CCE315CE06000566" modified="2019-02-13" version="1">MLEIARYDGRNRLRGSVYLAIAMSVLAVVVIWIYPSFSDSFDDVDEELLQAYPDEVIQLFDVQTMATLEGFLAFELYIFGWTILLGLYLAYLAAGAIADDIERGRMDILLSMPISRNRTVLEKFLALGVPIVVVNVLTPIVVYVSAELVDEPLSAVDVVAVHALSVPYLFACASIGLAASVAVDRTSIAQRAALGVTFGLFMLESLLVDTEYDAVGTIAPMRYYDPNEILLNSTYDLGNVGVLVVMTVVLVAVSVAWFDRRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4V9</accession>
    <name>A0A3N6M4V9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_09895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90281">
        <property type="protein sequence ID" value="RQG90281"/>
        <property type="gene ID" value="EA462_09895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="159" mass="17126" checksum="BAE37E3594E8EA2A" modified="2019-02-13" version="1">MPETGDTAPDFTVPLANGDVDSFTLSAALEEEAPVVLAFFPGAFTGVCTDEMCTFQGRLSAFEAVDASVYGISRDSPFSLNEFREQNDLEFGLLSDFNGEVIGEYGIEMDFDDLGVYGVAKRSVFVVDADGEIVYSWVSDDPGIEPEYAEVEAAVEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M504</accession>
    <name>A0A3N6M504_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90331">
        <property type="protein sequence ID" value="RQG90331"/>
        <property type="gene ID" value="EA462_10175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="72" mass="7965" checksum="0E34C5B499030C5F" modified="2019-02-13" version="1">MSEEVPVNRSDLVALLIVSVIGGVAVASWLLTPRLSPQYLNAVMVSSVMLAFFLFIPVMGIRLFVDDRQSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M525</accession>
    <name>A0A3N6M525_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87789">
        <property type="protein sequence ID" value="RQG87789"/>
        <property type="gene ID" value="EA462_13020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="271" mass="30046" checksum="902EC3FE95D5246B" modified="2019-02-13" version="1">MGIGYTTILYDDESLADGIADIGACRYDGVEIGLEKVRAAGPEHVSACLEEHDLELYCVMSGWFESDEDVEGFADDAATVAEMGAEYYGLLPPQRGGTDDETFAGWLETFCEAATDAGLTPALHHHGATHVEQPDEIEDWLARGPDSLELLYDTAHYYPYADPLSGIERFADDIAYVHVKDVAPSADFGVHTDALTSGEFHLDNVINYFRAFTDLGEGEIDFDAVVRTLEDVGYDGHVTIEIENETERPLVHAKQNFDRWQASRRSLTDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6L8</accession>
    <name>A0A3N6M6L8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88966">
        <property type="protein sequence ID" value="RQG88966"/>
        <property type="gene ID" value="EA462_11290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="223" mass="24557" checksum="A3290F55042CE0D5" modified="2019-02-13" version="1">MSHPRLNRRKFVVAAGTASALVLAGCADEGPGDEDDDPAADDPDDDPMDDDEDENGLEDEDDDPMDDDEDEDETYTLTVTVEDDEAEPVEGATVTLEEDGAMDDDEDENGLDDEDDGMDDDEDENGLDDEDDGMDDDEDENGLDDEDEEEWEEETDEDGQVEFEDLEDGEYTARAEYEGDEAEDDVEIDGDDEELTLTLGEEAETDDEADDGMGDDEDEDDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7L6</accession>
    <name>A0A3N6M7L6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91331">
        <property type="protein sequence ID" value="RQG91331"/>
        <property type="gene ID" value="EA462_04950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="129" mass="14698" checksum="30CDF2301563F187" modified="2019-02-13" version="1">MAKDTVRYPDEVVEEIDTLVQDGMFESKSEFYRFSAEYVLTLVNPDHDVKTFNYDEIKTELDISDADHGKALGTDGGTFFLDAVITVRKQGLRGNYEAAERFIDTHYDATDQECIILEELLGTYRNGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCA4</accession>
    <name>A0A3N6MCA4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93121">
        <property type="protein sequence ID" value="RQG93121"/>
        <property type="gene ID" value="EA462_02645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="261" mass="28681" checksum="6B7DB530B1A48D02" modified="2019-02-13" version="1">MSEPIVTDSLARVDWRALENTGREFKYQREASDRVTDTDRIEQRLSALERTVIDGDFEADELADRATIIDDLERLESRLDSHEGRLADVEGRMDAVAGFVGRIDAVNDDVEREATTALAVVDRLETRLDALENRLEDGTVARNPEASVGSEAEDGPDPKRSSALDEQSGKRRFRERGTKAPEDVIDELQAELDTRETGGCLTETDPDIRERTTDAADQHLVDRRFSSTENPTADDGSNTSAQSTATSGSGGLLGSLLAPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MG05</accession>
    <name>A0A3N6MG05_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92856">
        <property type="protein sequence ID" value="RQG92856"/>
        <property type="gene ID" value="EA462_01125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="178" mass="20276" checksum="99096A4B6F83434C" modified="2019-02-13" version="1">MTRPGDGERAHRGNGSDSFTPATSEDENARRSIDWDAFSHAFVPMGLRSRAIAVDVSTDRDVYDAGEPVRITVEFRNRLPFPIRLRTDSPNRWTWAVDDVTAASTVPRTVPDRPSAFSFARGERKRFHRTWSQRIRVDEREWVPVESGTHALSARVNRDDAVDRGLIDRTTIEIEDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGH8</accession>
    <name>A0A3N6MGH8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93056">
        <property type="protein sequence ID" value="RQG93056"/>
        <property type="gene ID" value="EA462_02275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="243" mass="27396" checksum="FE34587294A43F18" modified="2019-02-13" version="1">MQAVVLAAGKGTRLRPLTEDKPKVLVEVDGKPLVEDVFDNLLEIGVTELIVVVGYRKEQIIERYGDEYEGVPITYTHQREQLGLAHAILQAEPHVDDDFVLMLGDNIFRGNLGDVVNRQREDRADAAFLVEEVPMEEASRYGVLDTNEYGEIVEVMEKPDDPPSNLVMTGFYTFTPAIFHACHLVQPSDRGEYELPDAIDLLIQSGRTIDAIRMDGWRIDVGYPEDRERAAERLEEKAQTPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MR37</accession>
    <name>A0A3N6MR37_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_16320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86703">
        <property type="protein sequence ID" value="RQG86703"/>
        <property type="gene ID" value="EA462_16320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="12"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG86703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="366" mass="39447" checksum="58A03683F40A0ACC" modified="2019-02-13" version="1">MFDLARQHSDRDLVHLEIGEPDFDTPEHIIDSAAKALRNGATHYTTSAGIPELRTAIATDLDSEYDPESEIIVTAGAVEALALACLTVVDPGDEVIIPTPSWPNYQIQAIMAGGEITNVPLDEERGFSLDIELLTDKITDDTAAVLLATPSNPTGQVLDSSATAEVVKAAANHDAYVIADEVYKDIIYNQESTPIAANTAYPEHVITVGSCSKPYAMTGWRVGWFAADSEIIDAALEFHESIIACAPAPSQQAAVAALTGDQEPVQSIFSSLSERRDYVVERVESLPGVVCPEPEGAFYAFLDCGELERNSTTISKQLLEEHGVVTVPGTGFGPGLDDYIRISFANSLDRLELGFDRIEKYAESVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MS78</accession>
    <name>A0A3N6MS78_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF4040 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_15740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87083">
        <property type="protein sequence ID" value="RQG87083"/>
        <property type="gene ID" value="EA462_15740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG87083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="183" mass="19372" checksum="5FE88BC8353DEE17" modified="2019-02-13" version="1">MSAIAYTLVIFILLTALATALFRDVLSAIVVFGAYSLGMAILYTYLLAPDVAMTEAAIGAGVTTILLLLTIARTSRPPTDRLFERLDVPAVAVSGAFVLVLIVGLLPEMYAVGDPDAPIWGWDGLSETPSLYYVQNTFADTGAQNAVSAVLASYRGFDTFGEAVVVFAAGVAVLLVLKREVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUH3</accession>
    <name>A0A3N6MUH3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89052">
        <property type="protein sequence ID" value="RQG89052"/>
        <property type="gene ID" value="EA462_11785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051741">
        <property type="term" value="F:2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044649">
        <property type="entry name" value="MPBQ/MSBQ_MT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031164">
        <property type="entry name" value="SAM_MPBQ_MSBQ_MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44516">
        <property type="entry name" value="PTHR44516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51734">
        <property type="entry name" value="SAM_MPBQ_MSBQ_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MPBQ_MSBQ_MT" evidence="1">
        <location>
            <begin position="2"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="207" mass="23565" checksum="8CF24B0F762642C3" modified="2019-02-13" version="1">MGVLEHKGRARLFYKYLSTVYDRVNPFIWTEEMRTDALSLLEFEPEMTVLDVGCGTGFATEGLLEHVDEVYALDQSEHQLEQAYAKLGKRAPPVHFHRGDAERLPFATDTFDVVWSSGSIEYWPNPILALREFRRVLKPGGQVLVVGPNYPDNPLTQKLADAIMLFYDEYEADRMFKTAGFEDVKHAFMGPQYDPDVAITTIARAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N060</accession>
    <name>A0A3N6N060_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91252">
        <property type="protein sequence ID" value="RQG91252"/>
        <property type="gene ID" value="EA462_04475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="529" mass="59104" checksum="912045E385ED4784" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3Z2</accession>
    <name>A0A3N6N3Z2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92882">
        <property type="protein sequence ID" value="RQG92882"/>
        <property type="gene ID" value="EA462_01270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="81" mass="8986" checksum="3C5680669F9A7F13" modified="2019-02-13" version="1">MADITMYNLPGCPYCAKVRSKLDDLGLEYDVIEVPRSHDERTEVEAVSGQTGVPVITDEANDIVGMNESDDIVDYLEETYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4J4</accession>
    <name>A0A3N6N4J4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroorotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93102">
        <property type="protein sequence ID" value="RQG93102"/>
        <property type="gene ID" value="EA462_02545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="55"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="476" mass="53057" checksum="9C97404145022C3E" modified="2019-02-13" version="1">MVESTVDLRVTNARVVTPAGTISGGVAANDGTIVGVGTESNLPEADHEIDAEGNYLIPGFIDPHVHWGLSRYEFDYHEGLEHDFETETRGAIHGGVTTVVNFLLQKEPYLPDMEFFKRAGEENSYIDFAYHAIVHQDHHVEEIEDLAAEGIRSYKIFFNWYKNASPELGIDHSDAGGVYRVLDTVSDIPNGVVMFHAENEDLAIERRKELKAEGRNDLKAWSESAPNICEAMQIEQIGRLTEYTDSRAYIVHMSTGEGVDICERFQDRGVNLHAETLPAFLSHTNEREDLGVWGKISPPLRGEESTKRLWEGLRTGVVDYVGTDHCPHKIEFKEKDTGKHGDIWDAIPGDNNGIEYFLPVMMSEGVNENRISVERLVEVCSENNAKRWGLYPRKGALVEGSDADMVIVDLDKSTVVDDDFYHTMEPGYSTFHGEELTGLPTHTIVGGEVVVEDGELRAEPGGRNYLPRGPEGVSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4L0</accession>
    <name>A0A3N6N4L0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93122">
        <property type="protein sequence ID" value="RQG93122"/>
        <property type="gene ID" value="EA462_02655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="165" mass="17882" checksum="21DCAE8E528151F1" modified="2019-02-13" version="1">MDSQDQRTERPSERTTYRHRSLESDDRAIEGLPIRLVIALVVGVAALSIMLNMLGGVGEFGETEVTIEWEDDHVLEESQLASTLSFSIVDDEGNDVDGSTVIVTAGSAQLDDPVYVDGGGEITIPDHAGLRQDQNTGTLEVEIVPPNDSNYVDEQSNPEIVLVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N506</accession>
    <name>A0A3N6N506_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain-containing sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93292">
        <property type="protein sequence ID" value="RQG93292"/>
        <property type="gene ID" value="EA462_01585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="151"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="369" mass="41094" checksum="7EA80DF9FF18EB77" modified="2019-02-13" version="1">MDNDPRERDGGLESTLPSNRDPDRFRHLIEHIQDAVVEFELVDGEPIVGGVNPAFVDVFGYEAAELIGSSLNRYIVPKWLEDEATTLDDRTTAGKVNYRHVRRETADGLREFLYRGVPVDTNDGTDRGFAVYTDLTEDRRNRSRIDVLNRVLRHNLRNKVTLVAGSLEELLDEHDSSSVDSTDQQLYENACEGIEELRTLSREAGELYRIVEMPALSDSCVDCVPLARTVADRFESSHPAASIALDLPETLPVGATERLEVAITSLVQNAIEHNPADEPQVWIDGGMDGTEWCYLAVDDDGPGIPPVERDVITGDAEITETTHGSGLGLWLVKWSVETFGGELSFVRSRAGGSRVQLRLRHCRDDDRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NTZ2</accession>
    <name>A0A3N6NTZ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86156">
        <property type="protein sequence ID" value="RQG86156"/>
        <property type="gene ID" value="EA462_16930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="214" mass="22860" checksum="0B869E078BC0F047" modified="2019-02-13" version="1">MSVIRQPGMLGRTTRHRVVGLTVALTAATVETLAVGLWFVLVVGSRSTTTALAGLGILFCGSLLRTGVFGVAVSDLNDLLRPHRLAVALSLTAGWVIWLLVAELVGGTQGIAIATVTLVVVLVCQFAFERCVFEQRPSPRPTVESALTAITLAVGGAILLASVWFVDLTLVTPPLSFDVTTIVFRLEAVQLGSLAFGICAFLAHQYRFTRRLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NU23</accession>
    <name>A0A3N6NU23_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor Spt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spt5</name>
        <name evidence="6" type="ORF">EA462_17205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Spt5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86206">
        <property type="protein sequence ID" value="RQG86206"/>
        <property type="gene ID" value="EA462_17205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00950">
        <property type="entry name" value="Spt5_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011590">
        <property type="entry name" value="Spt5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00405">
        <property type="entry name" value="KOW_elon_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="145" mass="15850" checksum="0DB7E36314B8FB1D" modified="2019-02-13" version="1">MGIYAVKTTASQEQTVADMIINREESEVHAALAPDSLTSYVMVESDGHAVLERVLEEIPHARSIVPGESDISEVEHFLSPKPDVEGIAEGDIVELIAGPFKGEKAQVQRIDEGKDQVTVELYEATVPIPVTVRGDQIRVLDSDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUF6</accession>
    <name>A0A3N6NUF6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenylacetate--CoA ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_16795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86790">
        <property type="protein sequence ID" value="RQG86790"/>
        <property type="gene ID" value="EA462_16795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="69"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="3">
        <location>
            <begin position="349"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="446" mass="48989" checksum="E95FC475E38DAD89" modified="2019-02-13" version="1">MAGIDEGANIQSWTSILETHEQRLQEQIRYLLEESDYYRRKFDEWEIDPEEVRALEDLARVPFTTKDDERRCQHETEPDQPLGEHQAAPTGDLSITLSSSGTTGKPTYFGLTTDDREHWETLVARAAETMGVRSGDTVVHAIGRPIVPGGLPYINGFAKLGANVVPAGGGSSEQLLATLQDVSPDVLHSTPSHLEYLVDRAPEILGHGLDELGIRILIGGGEPGLGNPEVRERIRNGWGVNEIRDVIGIGDVSGAIAAECSHEHGAHYIAHGHIHPELIDPDTGERRSFEAGSDGELVYTPLTREATPLLRFRSGDYARVLGTDCPCGLKTPRVRIIGRADDMLIYKAKNVYPEALREVIVEVEGVTPQMKVVLPHDDKVQFTSPIPMRITRDESVARTDEAIVDELTSAVRNRLSVRVDPTLVSPGEIEPSQYKTDLIEIDEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUW2</accession>
    <name>A0A3N6NUW2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87020">
        <property type="protein sequence ID" value="RQG87020"/>
        <property type="gene ID" value="EA462_15370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="83" mass="8893" checksum="2553474A260D689F" modified="2019-02-13" version="1">MFVEVVCVSFTPLTSAETSACRHCGAHITNQFARVFGDDRDRAHRCGECDSYARLSRGSAAGLEVPIPDPETSLGRHGGEPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVF4</accession>
    <name>A0A3N6NVF4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87802">
        <property type="protein sequence ID" value="RQG87802"/>
        <property type="gene ID" value="EA462_13090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="60" mass="6703" checksum="AFD656530AB387D2" modified="2019-02-13" version="1">MLRPLFAICVLILLLLGFSFLFIEPGSESYVIAVFTLVPVVLVMVAIVILLVLGWDSHWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWE6</accession>
    <name>A0A3N6NWE6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Site-specific integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_10690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88859">
        <property type="protein sequence ID" value="RQG88859"/>
        <property type="gene ID" value="EA462_10690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="205"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG88859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="399" mass="46259" checksum="660B1CED356767A2" modified="2019-02-13" version="1">MTNHPDPLDNLPAGDGTRRDGLPPAPEQVEFDFPLASERTREDLENYGLNMVDDYRDFKKDLLSWLATYGKHPEKGQGLAESTLQSTHYKLEIVFRWLWEDEDGYTTDFTPDHADRFIRLLNRSDGMADSSVLHYGKAVQRLFKYQNHIHGTDYDWEPKPELSQATGDERDYLRRTAFKPLYQAALEHSSVKSYNSNMSTEERDRLKTHVSQRLGVPKSEVGPEHFEQANSWKGPSIIAVTLDTGLRPIEVGRATTDWVNLENNELNIPKDESTKNEAHWNCSIKKRTSRVLKRWLEERATYDKYNGRDELWLTKQGSKYSSKSCNYLLSRLVEQGDLPIPDHKDITWYSIRHGVATYWANHIGPHHAKEQLRHKSVTTTMKYLHSDAETRNDAAEQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NX16</accession>
    <name>A0A3N6NX16_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89159">
        <property type="protein sequence ID" value="RQG89159"/>
        <property type="gene ID" value="EA462_12385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="304" mass="33887" checksum="37BB8B088CA9F7F2" modified="2019-02-13" version="1">MVVKIIEQLEQPEYTGENRCVPCTVLNLAIAFIAGITIARKSKALSAVVFGVSIGLIYLRGYLVPGTPTLTKQYLPPEVLRWFGKKPEKPPVMTGLGDVEDAQNTTTAVTSGDPRPAGESEVTSIDYNQEKTDIEIYYEQLNVLKECENQDDLCLTEAFGNEWTERIESLESDEISSNQAVSMFGLEETNEEYIIEKHNDARVLLKDDNIIGQWPSEAALIADVSAASILSEWDGNWEQRRPQQKGELLSALRLFLEECPSDRGDVELIEDVVESCCYSRKVLAVVCSESGERLAEHPLNQIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ37</accession>
    <name>A0A3N6NZ37_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86766">
        <property type="protein sequence ID" value="RQG86766"/>
        <property type="gene ID" value="EA462_16665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="119" mass="12685" checksum="F48DA417C4C4FC79" modified="2019-02-13" version="1">MAVNVLIVDTSEAVRDVLREAISAEFHVVAEAEDGVEAIEIAETTDLDVVIMDIVMPGVDGIEATAKIKALHPDVSVIFCTSSTQQETMKSAIEAGGDGYITKPFEHSTIQDAVEDVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ47</accession>
    <name>A0A3N6NZ47_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_16715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86776">
        <property type="protein sequence ID" value="RQG86776"/>
        <property type="gene ID" value="EA462_16715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="269" mass="31070" checksum="F7AFAC5235F73D27" modified="2019-02-13" version="1">MTTDDSFAALLEYMERQLGFATSHYNDSYLDRRITARMRRTDCDEYDDYYDLVQSDRDEQAELLDSLSINVTGFFRNPDVWDGIRGVLRTLSKTERRLKIWSAACADGREPYSLSMLVHDDPVIDESSVRILATDISEDALEIAKNGVYEESRTTDLGEELSYLRGYDEYVSYDASAETYHVSDSVQKNISFEKHDLINGDPKSGFDLVTCRNLFIYIDTEYKQSMLETIARSLRSDRYLVIGKSETIPPELKSTFAAVDNRHRIYQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0K8</accession>
    <name>A0A3N6P0K8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88038">
        <property type="protein sequence ID" value="RQG88038"/>
        <property type="gene ID" value="EA462_14400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="90"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="317" mass="35997" checksum="117903D9A97EB553" modified="2019-02-13" version="1">MDHKSQTVHRTSSWHRVRDRLFETLSSKRNLALLTVLPALTLFALINIVPILWAIYAGFHDIFIFDPEWTWYGLENYRILWSDQQFHTSIIRSTTFAIGTVAFQATAGILIAVLVAREFRFNRFARAMVMMGYLIPTAIVAYMAYWMGNSTYGVVNWILLNLGLIDGMIAWFGDSTYAMISVIGVNWWKYTAFVVIMALARLQSIPDSHYEAARVSGASAWRQFRDITLPNLKGVIFIVLLLRGVWMFLHFDSVWILTRGGPGDSTMVSAVYAYETAFIGYDLGLTAAMSTVLFGILVVAAIIYFIVLEPEEEVRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3E9</accession>
    <name>A0A3N6P3E9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89805">
        <property type="protein sequence ID" value="RQG89805"/>
        <property type="gene ID" value="EA462_07235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="308" mass="34029" checksum="11BCBBA11EEBCE97" modified="2019-02-13" version="1">MGETIPVAVPRKGRPLETVLERFARRLDVADLADEITSTLRHEKALTKGTLEREGTSVYHRLEDYSTVSDPTKPEYTLIRDDRTGKPRRIVFDSVTIPLTEVEGVSDGTEVLLVGREEPFRALRTHEFALGFDSADLVLEEVVELRPEPLDRIGDVNARIDPADTDVQVVTGLGDTVYHTLMGTPETVPSATSIDRDFLEAYQGELCIEPRYERLVQAVLGTKTLDGVDFSYPRDDREEEAAIAETGLGVYLTMTGSTARDHGLLLGERLFPSETVLLENESEITESVATVRTVLNGTDLETALAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P454</accession>
    <name>A0A3N6P454_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_00060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92669">
        <property type="protein sequence ID" value="RQG92669"/>
        <property type="gene ID" value="EA462_00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="8">
        <location>
            <begin position="179"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="10">
        <location>
            <begin position="425"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG92669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="526" mass="59598" checksum="B05255601E062ED8" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4B3</accession>
    <name>A0A3N6P4B3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92749">
        <property type="protein sequence ID" value="RQG92749"/>
        <property type="gene ID" value="EA462_00515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="76"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="165" mass="18328" checksum="1B06F1C60E3F195F" modified="2019-02-13" version="1">MHEDAISTESVLEELSRAATDGTSESHSLDSADTSTDEGGIERELLGLLAEVTETIPAETTQFDEAIIKENLDEVLLMLITLHEETHGEELISDLARFFDTQLSPGTVYPLLHELKADDVLSMHAKVRTKEYSIADEEHVTAAIEESMIQHLTFGLLLYLFLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6K1</accession>
    <name>A0A3N6P6K1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">dapB</name>
        <name evidence="12" type="ORF">EA462_05680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91455">
        <property type="protein sequence ID" value="RQG91455"/>
        <property type="gene ID" value="EA462_05680"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="122"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG91455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="27169" checksum="06141C62316F2F63" modified="2019-02-13" version="1">MTARVGVTGATGRMGREVIAAVNDRDDCELAFAINRSPDGQSVGGTEIEPAADFETLLVDREPTVVVDFTGPESAREYASHCAETNVAFVTGTTGFDADDLEVLAAASDRVPVLRAPNFARGVQALLNVVGEAVRNLPGYDVELVETHHNGKRDAPSGTANRLLSEIEANGEFAERTHGREGDSPREAGEIGVHALRAGDITGEHEILLAGNHEEVRLTHRAEDRGVFAAGAVDAAVWLAERDPGRYEFADVISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6Z1</accession>
    <name>A0A3N6P6Z1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">trpB</name>
        <name evidence="14" type="ORF">EA462_06880</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91665">
        <property type="protein sequence ID" value="RQG91665"/>
        <property type="gene ID" value="EA462_06880"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="49"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RQG91665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="41198" checksum="AE50E02E3C36F8C1" modified="2019-02-13" version="1">MPDGEFDGYGGRYVPDPLQDPLEQLASAYDDVAGTDAFQDEFRDRLESFAGRPTPLYYAENLSNRYGAEIYLKREDLLHGGAHKINNCLGQALLAKRAGRGRIIAETGAGQHGTATAMVGALLGLETEIYMGKKDVERQEMNVFRMRLMGARVNEVTRGGEGLADAVDAALEDFAQNVDDTHYLVGSVVGPDPFPRMVRDFQSVIGTEAREQILDRTGELPDAAVACVGGGSNAIGLFHAFRDDDVAFYGAEGGGEGSDSKRHAAPLVNGTDEVIHGMKTRVIDDDVEVHSVSAGLDYPGVGPEHAMFRAVGRCEYHGVTDEEALAALRELSETEGIIPALESSHAIARAIQLAETGEHETILVNLSGRGDKDMETAATKFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6Z7</accession>
    <name>A0A3N6P6Z7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NOB1 family endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_06945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91675">
        <property type="protein sequence ID" value="RQG91675"/>
        <property type="gene ID" value="EA462_06945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="PTHR12814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN_6" evidence="4">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="152" mass="17218" checksum="51C2EF1C1B18BE9A" modified="2019-02-13" version="1">MYILDSSAFIHDFHTTEQTATIPLVRDELEDESAYRYDAMEGSGMHIHIPNEDTTEKVRRAAKESGDLEVLSDTDVRLVAASFELDGTLVTDDYAMQNVSEKLNVAVEVIAREGIDEQRHWTFQCQGCGREFDEEKDRCPICGSELTRKNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P731</accession>
    <name>A0A3N6P731_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_06270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91725">
        <property type="protein sequence ID" value="RQG91725"/>
        <property type="gene ID" value="EA462_06270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="4">
        <location>
            <begin position="3"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="177" mass="20021" checksum="C531D906D3676D1D" modified="2019-02-13" version="1">MSIYTGRGDDGKTDLRDMTRVSKTSPRIEAYGTIDELNALIGTIRSTGYDDIDDRLRTIQNHLHVVQADFANPDPDDDDPAIGTDHVETIERWIDEYDEELEPLTSFILPSGSDHGSRLHHARTVCRRAERRAVDLAIHEEVNENAVQYLNRLSDGLFTFARVVNVREGEPEEAPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9A9</accession>
    <name>A0A3N6P9A9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L40e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl40e</name>
        <name evidence="5" type="ORF">EA462_00770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92795">
        <property type="protein sequence ID" value="RQG92795"/>
        <property type="gene ID" value="EA462_00770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00788">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="L40e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_L40e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023657">
        <property type="entry name" value="Ribosomal_L40e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39649">
        <property type="entry name" value="PTHR39649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L40e" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG92795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="49" mass="5545" checksum="A34059B53C4652FB" modified="2019-02-13" version="1">MPTFDAAEKRTLEKMICMRCNARNPKDADNCRKCGYGNLRPKAKEARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9N8</accession>
    <name>A0A3N6P9N8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92975">
        <property type="protein sequence ID" value="RQG92975"/>
        <property type="gene ID" value="EA462_01810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="178" mass="18906" checksum="7CEEEC1E5117E1AC" modified="2019-02-13" version="1">MRLTRRNAILGLGTLAAGTGAIAATGAFDTVEADREVSVEFSDDSDATLTMVPNPDREGNDNFGEGETLDVSQTDGEIQISLNRINRNARVTFSDLVQFTNNGSQDITSLSFSLDQNEGSHGTLEVDPDDENILEDDLDVGDNVVGLGLVVDTLGEDLPPSEDIEMDGTITITANTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LI23</accession>
    <name>A0A3N6LI23_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-stranded DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86924">
        <property type="protein sequence ID" value="RQG86924"/>
        <property type="gene ID" value="EA462_14790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="2">
        <location>
            <begin position="72"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="2">
        <location>
            <begin position="176"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="494" mass="52472" checksum="8C4CE69B3B3EE282" modified="2019-02-13" version="1">MSDIEGVYEDLEADVSLEEFREAVEAKVEQMGGLADEETAAMLVAHEVGESEVGGIADIEPGMEEAKFVAKVVSIGEIRTFERDGEDEDGRVANVEVADETGSVRAAFWDDHARAAVEELEEGDVLRIKGRPKEGFSGVEVSVDDVEPDAETEIEVQISDTYTVESLSLGLSNVNLVGLVLDTGTVRTFDRDDGSEGRVANLVLGDSTGRIRVTLWDDQADLATEFDPDTTVEVVDGYVKERDGNLELHVGNRGTLEEVDEDVEYVPESTPIEDVEIGQTVDLAGVVRSADPKRTFDRDDGSEGQVRNVRIQDATDDIRVALWGEKADIDLGPGDEVALGDVEIQDGWQDDFEASAGWQSTITILESEAASADGTESDDSDENTGLSAFSGGGDDDPADSATETTAETDSGDAVASSETQDAGGETQESGGATDPTTGEELEFTGVVVQAGDPVVLDDGETTMSVDTDADVGLGEEITVRGVVHDGRLEASDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LID0</accession>
    <name>A0A3N6LID0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86909">
        <property type="protein sequence ID" value="RQG86909"/>
        <property type="gene ID" value="EA462_14715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="307"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="510" mass="56984" checksum="AD67A9AEA2973B64" modified="2019-02-13" version="1">MESVKPTLLIVSDSPDRPEFEEAIGRTGLTLEVRTAGDIPSATTIIESEQVDCIVSAYEIPDENGRLYMGGLRLLEYVRREHGELPFIIFTFVVNEDSVRRATTNGVTAYIRDIEGENVVGQLSYHINSAISRRLTERRADEQARINEIIRDVNDSLVREQVRDEMIRRISLELTTDDVYRTAGFVFLDRETERIDTWTSGDTASLNEGERTTELVSQTLESGSVTTNSTSPPRIAIPVVYEETRYGVLVLETNASHVFYETERAVLGELGETIGHALNAIDVRNSLVDRERELSEQKEQLEQFASIVTHEIRNPLNVAKGNLAALQEEHDDEGEDPEFEYIERSLERIDTIVDDILALVRTNASLDVRTTALERVVEEAWDTVETDDAILEIGDGRAVEADPSQLRRLFENLFRNSIEHATPPDGRLTVSVYVDGDAIVVQDDGVGIDEAILDDIFEMGMTGAGYGTGLGMAIVSDLAERHGWTVTASNYEDGARFRIRGLETKGVDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIF4</accession>
    <name>A0A3N6LIF4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87144">
        <property type="protein sequence ID" value="RQG87144"/>
        <property type="gene ID" value="EA462_15805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004376">
        <property type="entry name" value="CHP00024_Pesterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024173">
        <property type="entry name" value="Pesterase_MJ0037"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30337:SF5">
        <property type="entry name" value="PTHR30337:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000887">
        <property type="entry name" value="Pesterase_MJ0037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="235" mass="25295" checksum="7453F8DCE2243800" modified="2019-02-13" version="1">MATVDLPFSIEERAVFVPTADSLIVADIHLGRAAASSIDAPIDDGGDVRDRLASLLDRTDPSTVVVAGDLLHSFDTVPRGVERDVVALVSVIDDAGASLVVTPGNHDTMLADVFHGETTREYRLADDETVVCHGHEPPDEDAKRYVIGHDHPALSVEGRKLPCALYGPNAHEGSDVLVLPAFTRTAAGATINRMRSRDFQSPLISDADAFHPAVWDDSNGDTLWFPPLGRCRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ24</accession>
    <name>A0A3N6LJ24_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylaspartate ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">EA462_14440</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12829"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:36986"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="4.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methylaspartate ammonia-lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.2" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88046">
        <property type="protein sequence ID" value="RQG88046"/>
        <property type="gene ID" value="EA462_14440"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050096">
        <property type="term" value="F:methylaspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03314">
        <property type="entry name" value="MAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006395">
        <property type="entry name" value="Me_Asp_am_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022662">
        <property type="entry name" value="MeAsp_NH4-lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022665">
        <property type="entry name" value="MeAsp_NH4-lyase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07476">
        <property type="entry name" value="MAAL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05034">
        <property type="entry name" value="MAAL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017107">
        <property type="entry name" value="MAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00007">
        <property type="entry name" value="methylaspartate_ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01502">
        <property type="entry name" value="B_methylAsp_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAAL_N" evidence="14">
        <location>
            <begin position="4"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="MAAL_C" evidence="15">
        <location>
            <begin position="163"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>(2S,3S)-3-methyl-L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>(2S,3S)-3-methyl-L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RQG88046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="411" mass="44465" checksum="52C82BDD0B9B1179" modified="2019-02-13" version="1">MPAIADVVAVPTLGGYFFDDKEAIVTTADRDGFSYAGEPVTPGFSRVRQPAEAISVQIELTNGRIGVGECTAVQYSGFGGRDVYFDADSHLDDIEATVSDALVGRDASDFTNNVATIDEVAAETGGLHTAVRYGLSQALLETAAIADSKTMTEVITDAYDLDLVPQPVPIFTQSGSNRYDNAEKMILKRVPVLPHGLFNSVDDIGADGERLLEYLSWLSERISELGSSSYRPTIHLDIYGTVGEIFDPPYDTTDIVDYFAELERAASPYQLRIESPIEAGSRSEQITALGTLRDALTDHSIPVDIVADEFCNTYEDVTAFVDADAVDMVQIKMPDLGDLTNSIDAVRYCSGTDILAYLGGSCAETDISARVSTHVGLATRPDQLLAKPGMGVDEPYLITNNEMKRTLRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJG5</accession>
    <name>A0A3N6LJG5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_14630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88081">
        <property type="protein sequence ID" value="RQG88081"/>
        <property type="gene ID" value="EA462_14630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="66"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="6">
        <location>
            <begin position="324"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="78"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG88081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="427" mass="47250" checksum="9B1F74C9AFA0F082" modified="2019-02-13" version="1">MPNDPIPTPSIEDLEDDPMSTEDNSIFRRRELLRPQHVPQKDRIVGRDGEIETVETLLKPAAFGDPPESGFLFGKTGTGKSLVAKHVTGRARGVAQIQNVDLVAAYVDCDQYNTETRAARKMAFEVRDAIDPEYYIPQEGVGASRYYDTLWNADGLLNEADSLVVILDEIDKLEMDAAEILSKLSRSEEAGKTGCYISVVAISNKTDYTDAPDERVASSFQDDPIVFPPYDANQLEAILERRSDAFVDGVLETGVLPLAAALAARDHGDARRALDILRTAGKLAERDSSESVTEERVRAADEYSDINRSVQVIRNGTPHSRYALFALSYLTKSKLTDSFSTGEVYDVYRVVADVTAGESLSHQRVLDLLKKWTLPEITESRHTGGGKAEGSYRVHRLLHDPDIVMSSCLEDDELQTVLDTLSKHQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJJ8</accession>
    <name>A0A3N6LJJ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Patched family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_10830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88883">
        <property type="protein sequence ID" value="RQG88883"/>
        <property type="gene ID" value="EA462_10830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="765"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="795"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="839"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="868"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="353"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="729"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG88883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="914" mass="98598" checksum="DC4B8E3306D32544" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKI4</accession>
    <name>A0A3N6LKI4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DHH family phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89158">
        <property type="protein sequence ID" value="RQG89158"/>
        <property type="gene ID" value="EA462_12375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="363"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="505" mass="53213" checksum="9F86181EB5EF1B1B" modified="2019-02-13" version="1">MAGPIPDLEERATLCARRLYSADRVLLASHIDADGLTSAAIAAQAIERAGIPFETVFEKQLDEDAIAALAATEYDTVLFTDFGSGQLDVIGQHEDAGEFTPVIADHHQPADRETKYHLNPLLFGINGASELSGAGTSYVLARALAAVSDDGSDTSQGVATDGGVGANTAAPDDATDARPDNTDLAALAVVGAVGDMQASSGELHGANAKIVEEGVDAGVLETGTDLALYGKQTRPLPKLLEYATDVHIPGISNDERGALRFLDGLDLELKRDGEWRRWSGLTNDEKQTVASALVKRAVTKGVPATKIDQLVGTAYVLAEEPVGTELRDASEFSTLLNATARYDRADVGLGVCLGNRDEALERARKLLRNHRRNLSAGIDLVTREGVTVEDHVQWFHAGDRIRETIVGIVAGMAMGNAGISRSRPILAFAEKGVDGDDEPDLKVSSRGTHSLVRRGLDLSVVMGEASRAVGGDGGGHDVAAGATVPNGAEREFIERADEIVGNQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKJ8</accession>
    <name>A0A3N6LKJ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthine synthase</fullName>
            <ecNumber evidence="6">2.1.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dphB</name>
        <name evidence="9" type="ORF">EA462_15035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36415"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="2.1.1.98"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.98" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86968">
        <property type="protein sequence ID" value="RQG86968"/>
        <property type="gene ID" value="EA462_15035"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="PTHR10882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6 7">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG86968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="257" mass="27971" checksum="77D01E78C7B8E48A" modified="2019-02-13" version="1">MLTFIGLGLYDERSITIEGRDALRNADRVYAEFYTSELIGTTVAELESYHGVEITVRDRAGVEQRPDDILRAAGSENVVFLTAGDTMISTTHVDLRLRAHDRGIETRIIHGITAQTATSALTGLQNYRFGKATTLPFPYAHGADGLPASVTETIEDNRRDGLHTVVYLDIKVEREEYMTADVGADLLAEAYPDLVGVVVARAGSPDPLVDGGRMSDLATREFGDPLHLLVVPGECHLLEADALVELGGVDREHLDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKN6</accession>
    <name>A0A3N6LKN6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lasso RiPP family leader peptide-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89228">
        <property type="protein sequence ID" value="RQG89228"/>
        <property type="gene ID" value="EA462_12750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="47" mass="4975" checksum="27985FDFAE577E0C" modified="2019-02-13" version="1">MSEESNSTYESPAVTEYGSVESITENDKHGNGDDQYSSATSLTGSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKT6</accession>
    <name>A0A3N6LKT6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87108">
        <property type="protein sequence ID" value="RQG87108"/>
        <property type="gene ID" value="EA462_15890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="60" mass="6801" checksum="9305C4A234C1E67A" modified="2019-02-13" version="1">MTVNEAPVPENGQFGDAQLELLTDDEEVWTVVPVDARGDQRVSEWLSIDSSGLRDLEEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLJ4</accession>
    <name>A0A3N6LLJ4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">grpE</name>
        <name evidence="6" type="ORF">EA462_07560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89863">
        <property type="protein sequence ID" value="RQG89863"/>
        <property type="gene ID" value="EA462_07560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="384" mass="42647" checksum="C19C966A61CC3401" modified="2019-02-13" version="1">MSEDEGTNSAAQSVPSEEESDENEPERGETDADANAETPQSPASSESAEGDSAEGGQRSDSSESVSREETSEEVRQILDRVTEYDDELGDRINSIVDEIRQLSTTVDHQREELEDLSERIEAQADTIDELQEDIEAREKVISEREDRLEEYESELEERKAEVVEYESEIEDLQSRLKRKQADFQNYKKRAKKRQQQIKDRATEDLVERLIGVRDNLKRALEDESGDADSLRDGVEMTLREFDRVLEDENVSEIDPEPGTETDPQRHEVMMNVDSALPEGTIADVYTPGYEMGDKVIQNAQVTVSNGELEEESAERESEPASDSGNEPETADDSTGSQADDADETGDDGDEPEEDAIELDGAVDDGADEATDGDTEDSDDGSSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLP2</accession>
    <name>A0A3N6LLP2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fructose-1,6-bisphosphatase class 1</fullName>
            <shortName evidence="5">FBPase class 1</shortName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fbp</name>
        <name evidence="9" type="ORF">EA462_07950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89933">
        <property type="protein sequence ID" value="RQG89933"/>
        <property type="gene ID" value="EA462_07950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="PTHR11556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBPase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="FBPase_C" evidence="8">
        <location>
            <begin position="159"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="281" mass="30334" checksum="15461A4AC299DCCC" modified="2019-02-13" version="1">MTDTVEDVVRVIARSATEIRRGLVGRRGKVDEENPSGETQAEADIWADELLADRLSTTDGVVQYASEERTDDLNCGDEGLAVAVDPLDGSSNLRSNNTMGTVFGIYDEPIPAPGTALVAAGYVLYGPITTMVYARDGQVTTYELSGGERTVVDEDVIVPDDPVVYGFGGRVPNWTDDFHQYANEIEDELKLRYGGSMIGDVNQVLSYGGIFAYPALEDSPNGKLRLQFEGNPIAYVMESAGGRSSDGTQSILEIEPTDLHGRVPLHVGNADLIDRLEAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLT9</accession>
    <name>A0A3N6LLT9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RsmB/NOP family class I SAM-dependent RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_07585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89868">
        <property type="protein sequence ID" value="RQG89868"/>
        <property type="gene ID" value="EA462_07585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="17"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="106"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="303" mass="33495" checksum="C8E5B077E9279A84" modified="2019-02-13" version="1">MEALERYRPIVDEFERFLAACERPLGNAVRVNTIKAPVERATATLEEEDVAFEQASWNPRVLRLETDSPGSTWSSVHGFTHGQEEVSAVPPVVLDPQPGERVWDCCAAPGGKTTQIAARMDDRGTVVANDNNLGRLSALRFNAERLGATSLAVTNADARNFSMKPFTFDAFDRSLVDAPCSCEGTIRKNPDALDNWSEDHLHSVAGIQKGILRRAIQTTREGGTVVYSTCTFAPEENEAVVQHAVENEPCRVVDFDFDLEYAPGLREWNGEAFDPTLERTARIYPHHNDTGGFFVAKLEVTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLX3</accession>
    <name>A0A3N6LLX3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Squalene/phytoene synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89928">
        <property type="protein sequence ID" value="RQG89928"/>
        <property type="gene ID" value="EA462_07925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="PTHR11626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="348" mass="39858" checksum="267E496BEF203D01" modified="2019-02-13" version="1">MTPAQSEITTNADLEWCYDAVHGVSRTFSITIDRLEEPMARHICLGYLLCRIADTIEDAGHIPPKTQTDLLNEYDRLLDHEDDRAVETFMTDVEPWIPEEANEDWEVVAQTPRVLRTFESLEDEPREIMREPVRELVDGMAMFTARYADEGGLRLQTLEELEEYCWYAAGTVGTLITGLVARGASQERADEMRSNARSFALLLQLVNIAKDVDADYREENNVYLPAEWLEEEDVALDAVTDEENHGGVTNVIRRVTGRAETYLDDAQRYLEVVPEQHGNRLSAWAIPYLLAVGTMRELRERPEDVVREGDVKITRAEVYALLQTFEDDVSRSHLDELRSEMAERPLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM19</accession>
    <name>A0A3N6LM19_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0212 protein EA462_08955</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0212 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90113">
        <property type="protein sequence ID" value="RQG90113"/>
        <property type="gene ID" value="EA462_08955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01223">
        <property type="entry name" value="UPF0212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007564">
        <property type="entry name" value="UPF0212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42199">
        <property type="entry name" value="PTHR42199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04475">
        <property type="entry name" value="DUF555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016934">
        <property type="entry name" value="UCP016934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="117" mass="12361" checksum="3D18F3379DED8748" modified="2019-02-13" version="1">MGNYLVAMEAAWLVRDVNEIDDAIGVAVSEAGKRLNSEGLEYVEVEVGATGCPACGEPFDSAFIAAQTSLVGLGLEMEVFNADNEEHASRIAKSEVGGALRDVPLSVSQVIETDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LME2</accession>
    <name>A0A3N6LME2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90178">
        <property type="protein sequence ID" value="RQG90178"/>
        <property type="gene ID" value="EA462_09320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="204"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="379" mass="41581" checksum="E30D9C5C69FF3D94" modified="2019-02-13" version="1">MNRVEGANNKEKASTSVGEESSECDRSGTAETESILIVADHPNASKIERHYGPLAAVAGETTMVCLTPDESVESITYRTVPTFGWRPLGIVLLFFAALVEGVRNEYDTIVSISLIPYGCYALALRPLVGARTHLGIIGADLDVHARGPYAPLTRVALRRFDSLSVPGSVHSRRLREMGIDDDRIDILSNAIDTDRYAPPDEPVEPRYDFLWVGRFSEEKDPLLFVDALAMLSEAGLEFSAAMVGSGGKHRDVVRAIDHYGLEDAVELPGWVDDPREHYTAAHIFVLTSSRDALPLTLLEAMATGTPAIVPRVGSVPDVARHRETALVVDQRTPAAYADALATLCTEDDLHERLSTAAPTVREEYSYAAARDDWRRILER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMH2</accession>
    <name>A0A3N6LMH2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90218">
        <property type="protein sequence ID" value="RQG90218"/>
        <property type="gene ID" value="EA462_09545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="125" mass="13801" checksum="67688ABC7BBDBFDF" modified="2019-02-13" version="1">MSYRKVNYEDVDQVSSAMHFLSDPLETERVGVTVARCDPGWMSQSHDHADNDHEEVYVLIEGEATVVVDEDPIEMETGDALWIPPESTRQIQNGDEESAFVLVSAPSIGDDDDEGGEWLLTGFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMK8</accession>
    <name>A0A3N6LMK8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90278">
        <property type="protein sequence ID" value="RQG90278"/>
        <property type="gene ID" value="EA462_09880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="87" mass="10067" checksum="B2A91609457A8475" modified="2019-02-13" version="1">MICVVIVCTDGRQSLKRFRRHQQGNATVSARDRWRFVREVISGTTIVQSPIQTETTVKRCFARIRDEQLEFESPHSAGSKQGYRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMK9</accession>
    <name>A0A3N6LMK9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit beta/FixA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90373">
        <property type="protein sequence ID" value="RQG90373"/>
        <property type="gene ID" value="EA462_08985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="291" mass="31663" checksum="A700672C4FBE93B9" modified="2019-02-13" version="1">MRSIVLTKGVPDFSEGAVSFDEDGHLERGKTPTVMNPNDGFAAEAALQTRVRHGGHVSAMSMGPPGYAEVLEEAMESVYADDSYLLSDRELAASDTWATAITLSAGLEKYQEEVGEIDLVFAGFKSADGETGQTGPQTSWALDWPIVTHVIALDIDPDERLLRAKRLVEGDVDEIETVEAPLPCFVVTDPEFEPTYRKASHRLSHKRLRSETQGRASDHEEHLTTWSQEDLNLDPEYIGLDGSPTIVSSVDPIPKAPSEREATMIEFDDDDGMGQVLGEMQPFAASGGDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMX7</accession>
    <name>A0A3N6LMX7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5808 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86905">
        <property type="protein sequence ID" value="RQG86905"/>
        <property type="gene ID" value="EA462_14695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043831">
        <property type="entry name" value="DUF5808"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19124">
        <property type="entry name" value="DUF5808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5808" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="94" mass="10422" checksum="5605DE9DC9B6B126" modified="2019-02-13" version="1">MADKPTSGEILGVPYNFDRPSLSRMISSYWKPGEGMLVEKPFGVGYTLNLANWRSWVVVLVAGALLWQQEQSTSEASEESEDEPVEVIVDDGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNQ7</accession>
    <name>A0A3N6LNQ7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable deoxyhypusine synthase</fullName>
            <shortName evidence="7">DHS</shortName>
            <ecNumber evidence="7">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dys</name>
        <name evidence="9" type="ORF">EA462_13175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 7">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87817">
        <property type="protein sequence ID" value="RQG87817"/>
        <property type="gene ID" value="EA462_13175"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00153">
        <property type="entry name" value="DHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022899">
        <property type="entry name" value="Deoxyhypus_synthase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG87817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="324" mass="35786" checksum="ACF39BFDFE4CCDC4" modified="2019-02-13" version="1">MDEDDSRAHVVPGSDEELDGADVRGYDFRGSFDFDAMLDSYATTGFQATQLAEAIDIAERMQANDATIYLTITSNIVSSGLREVVAYLIREGYVDVLITTSGSLTEDVIKTEKPFKMGEWDADESELREQGINRLGNIFVPSDRYVWLEEYLYEFFEDFFAEEKVRTPTAFARELGETLDDEDSVLKQAADNDVPVYCPALTDAEVGNFLYYYRQGYDSDVGIEILDDYDSLIEEALLSDTTGLIAVGGGVPKHHAIMTNLFRGGADYVVYISTGIEGDGSLSGAPPNEAVSWGKIKDAENNYTQVEAEATLVFPLLVASAFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP07</accession>
    <name>A0A3N6LP07_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89797">
        <property type="protein sequence ID" value="RQG89797"/>
        <property type="gene ID" value="EA462_07195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="77" mass="9007" checksum="31B5DCCE9AC61748" modified="2019-02-13" version="1">MHTCRNCNQSFQTELALELHRDTCRKGQLFCQICGERFREGDATQDGWHYECPNEDCDGDGLQQDLYHVEDVRTTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP32</accession>
    <name>A0A3N6LP32_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87997">
        <property type="protein sequence ID" value="RQG87997"/>
        <property type="gene ID" value="EA462_14160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="110" mass="12089" checksum="DAC7DFDC324F77B0" modified="2019-02-13" version="1">MKGYYVRYLQVLEAELGDRIALKVRRPELAAALLSYNGTIRRGGFAFDEECREVTFRTPFVPVTEPVVDAAAENVTAVAEHVRTGGGSPFEIYLTERTGFTVTDSTPDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP99</accession>
    <name>A0A3N6LP99_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_13335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88097">
        <property type="protein sequence ID" value="RQG88097"/>
        <property type="gene ID" value="EA462_13335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="71"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="256" mass="28290" checksum="84185BC5E5495B2A" modified="2019-02-13" version="1">MAIRTTDQSNVKTIDRTARILETLKELDGARVSEVADELDLANSTAHRYLSSLKKNEFITQEGDFYYVGLRFLELADSAQNRTEVYKLAKPKVEQLAQETGERAEFIVEEHGYAVFVHRAIGETAVRANSHQGKRIPMHATSAGKVILAHSPERKVEEIIECRGLPELTSETITTREELDEELEEIREKGVGFAEEEYIQGLSTVSVPVKGSSGAIQGSLGISGPSGRMSGDNFKREIQNLLVGAANELEINIAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPB0</accession>
    <name>A0A3N6LPB0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M24 family metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89957">
        <property type="protein sequence ID" value="RQG89957"/>
        <property type="gene ID" value="EA462_08085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="134"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="367" mass="40563" checksum="8115684CAD5E560F" modified="2019-02-13" version="1">MDKRERLESYLETRDLDSVWFARPNSFAWLTGGTNVVDRETDAGVAAVGYDGADLTVLTDNIEADRIVDEELPDLETSEFSLERFPWHASSLAEAIEAHVKNDGRASADVAVPGFETVDPTPLRQPLTEQDRERYRRLAQETAAAVESVCRELRTTDTELEVASAIRVALSAREIEAPVVLVGGSERVQRYRHYTPKRTELGEYALVSVTTQRWGLHASCSRTVAFDPPEWLEERHEAATRVETAALAATRSVAADGGTAGDVFTAIQEAYDDVGYGGEWRHHHQGGAAGFSGREWIATPDHEASVELPMAYAWNPTVQGAKSEDTVLITDDDYEILTRTDNWPMTTVDAAGVDESLERPDVLVLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPL6</accession>
    <name>A0A3N6LPL6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_05575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91438">
        <property type="protein sequence ID" value="RQG91438"/>
        <property type="gene ID" value="EA462_05575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="66" mass="7673" checksum="6B2D58F715CBB8A9" modified="2019-02-13" version="1">MRWNPRTSGTDRCQKCGNHVTPEFRRGYGDRRDRAHRCPGWNTVRSLGHRGAVGNEVVSPFPRLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ18</accession>
    <name>A0A3N6LQ18_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90317">
        <property type="protein sequence ID" value="RQG90317"/>
        <property type="gene ID" value="EA462_10095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="169" mass="19762" checksum="B0A35AA793967F25" modified="2019-02-13" version="1">MAAGYLIKPLVDRGRDELADAVWKRSIQPRIATPPSKVERFARGRLSTIVLEEGFPESRRERIKRRVENVFLNGVIWWSEGGVVLDATIENPEQVDSETIESAYMLHQDIDVDVYSTHREHRPWRFHFDVESVSEFLWATEYLDHAVERSRLRPEQNETIHSSFEVDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ28</accession>
    <name>A0A3N6LQ28_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91668">
        <property type="protein sequence ID" value="RQG91668"/>
        <property type="gene ID" value="EA462_06900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="253"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="374" mass="38844" checksum="7B1CC1D626A118E7" modified="2019-02-13" version="1">MDDHRLNRRRLLSLAGGGFASVLAGCAAPQRDSAVEGSSSQEQSATHETDGELETDAGFTDVYDAIIDSVTQVRVFGVDNPLTGGEGRGQGSGFVYDDRHIVTNDHVVADGEEVDLQYINGDWTDTKLVGTDPFSDLAVLEADHVPSSATPLSVAEYSPSVGQQVLAIGNPYGLEGSMSSGIVSGVERTVDAPGRTFSFPNVVQTDAAVNPGNSGGPLVDLDGNVVGVINAGGGDNIGFAISAALTDRVVPALIETGEFEHSYMGIRLASVDRIIAETNDLEEATGVIVTEVVSGGPADGVLQGADRVTREHGEPIPIGGDVIVEMNGHPIPDRHALSTVLALETSPGETLEITLRRDGSETSESLDLGARSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRP1</accession>
    <name>A0A3N6LRP1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase</fullName>
            <shortName evidence="3">SEPHCHC synthase</shortName>
            <ecNumber evidence="3">2.2.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthesis protein MenD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">menD</name>
        <name evidence="7" type="ORF">EA462_07345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="ChEBI" id="CHEBI:58818"/>
            <dbReference type="EC" id="2.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="3">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPP enzyme family. MenD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89824">
        <property type="protein sequence ID" value="RQG89824"/>
        <property type="gene ID" value="EA462_07345"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01659">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004983">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00173">
        <property type="entry name" value="menD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="12"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="460"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG89824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="611" mass="65829" checksum="1730EB37C1928F98" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRU8</accession>
    <name>A0A3N6LRU8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89914">
        <property type="protein sequence ID" value="RQG89914"/>
        <property type="gene ID" value="EA462_07845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="63" mass="6847" checksum="44458CB867142F27" modified="2019-02-13" version="1">MSPELVGRLTRSERWTAVLVVVFTATIYPVYAVANPSLWLAWAIGTVATAGSLLVILNRSRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS41</accession>
    <name>A0A3N6LS41_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Catalase</fullName>
            <ecNumber evidence="2 9">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_04865</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="2 9"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91317">
        <property type="protein sequence ID" value="RQG91317"/>
        <property type="gene ID" value="EA462_04865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="PTHR42821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="11">
        <location>
            <begin position="96"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG91317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="786" mass="87411" checksum="05042281FE28A694" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSC7</accession>
    <name>A0A3N6LSC7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">B(O/a)3-type cytochrome-c oxidase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_00870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92813">
        <property type="protein sequence ID" value="RQG92813"/>
        <property type="gene ID" value="EA462_00870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01660">
        <property type="entry name" value="ba3-like_Oxidase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033943">
        <property type="entry name" value="Ba3-like_Oxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="7">
        <location>
            <begin position="20"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="595" mass="65581" checksum="586B80A81D8DE93D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSD4</accession>
    <name>A0A3N6LSD4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92828">
        <property type="protein sequence ID" value="RQG92828"/>
        <property type="gene ID" value="EA462_00960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="80" mass="8804" checksum="F35AD345346641CA" modified="2019-02-13" version="1">MVFDANVFNRACRGTTERRGIFRGDANIGEGPLNEEAHALDVLCPDRVVEALADASTNRSRATCFCDRERRTVVPGPLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSH9</accession>
    <name>A0A3N6LSH9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_01365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92898">
        <property type="protein sequence ID" value="RQG92898"/>
        <property type="gene ID" value="EA462_01365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="316" mass="33504" checksum="902B2271E888A0CE" modified="2019-02-13" version="1">MSVVVTNGLTKAYGDVTAINDLNLDIDEGEVFGFLGPNGAGKSTTINVLLDFVTPTAGSATILGHDTQENTREIHRRIGVLPEGYDLYDRLTGRRHIRFATATKQADDDPAEILERVGLDPEDADRAVGEYSKGMKQRLALGMALTGSPDLLILDEPSAGLDPSGIQRMQEIVRTEADRGTTVFFSSHILGQVEAVCDRVGVLNHGELVAIDTIEGLRETFGSGATVSLELDSVPESAVSSLSDIDGVTGYDINAQRLAVQCGDPRAKARAINHVEGAGATVLDIHVEEAGLHALFDELTGTDSAIGEPEEEGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSL8</accession>
    <name>A0A3N6LSL8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4976 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_01645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92948">
        <property type="protein sequence ID" value="RQG92948"/>
        <property type="gene ID" value="EA462_01645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="3">
        <location>
            <begin position="377"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="495" mass="56011" checksum="7F1E427F8968C39B" modified="2019-02-13" version="1">MSDADARPNVLFVLTDQERYDCSAPDGPPVETETMDRLSSQGKRFSQAFTPISICSSARASLLTGRFPHGHGMLNNCHEADAIRTDLPPDIPTFSEALEANGYDCTYTGKWHVGRNRTPENYGFSYLGGSDTHHDDIDEAFREYRRQRGSPLDEVDLTERIYTGADPYDDESGTFVSAKTPTDVEETRAWFLAERTIDAIDRHSSGADGSGPFFHRADFYGPHHPYVVPEPYASMYDPAEIEPPESYAETFDGKPRVHENYLAYRGVTDFEWETWADALAKYWGFVTLIDDQLERILDALESSGLAEETVVVHSSDHGDFVGGHRQFNKGPLMYDDTYRIPLQIRWPGVVDPGSTCSRPVHLHDLAATFLEIADVAVPETFDARSLVSLLENHSEERPVWPDSVFAQYHGDEFGLYSQRMVRTTRYKYVYNGPDVDELYDLEADPGELQNLIDHPDYEAVRHGMRERLIEWMDDTNDPNRGWVPDVLRGASQDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSS3</accession>
    <name>A0A3N6LSS3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phoU</name>
        <name evidence="3" type="ORF">EA462_02105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93028">
        <property type="protein sequence ID" value="RQG93028"/>
        <property type="gene ID" value="EA462_02105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="128"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="219" mass="24691" checksum="40AC7DB937230FC2" modified="2019-02-13" version="1">MTRTAYRAQLEQLRTNVFEMSETVCRRLRQSLDALEANDDELADAVIAGDDEVNRRYLELESDCIELLALQQPVASDLRFIASSFKIITDLERIGDLAVNLAEYSRRAERDRYPEIDIVHIGTETVFLVEDAMRAYATDDADATRDIAARDDEIDALCERASRTVVRGLVDADAADDALLADVSRMLLTIRDLERVGDHAVNVAARTLYMVDNDDELIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSX9</accession>
    <name>A0A3N6LSX9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93108">
        <property type="protein sequence ID" value="RQG93108"/>
        <property type="gene ID" value="EA462_02575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="252" mass="28958" checksum="1D61D96CAB08F8E2" modified="2019-02-13" version="1">MLDGYEMYDLTQPWSQDTPAWPTYDNPKVWYEKSLDTEKVNGQKIEFMNHTGTHLDGEKHFVAHGRDIEQVGLDELVGDAVVADISEKVGDYDVYTSEMIEEVCDVREGDILFIHTGYQEYAWHEENADPHRFFCKHPGPNAEFAEWCLEMDINYLILDCGSADHPMNTVIRDIRPELAAEARDHFGVDDLDEIFPPEGYQLMHTELFPEGIIHVENGQVPEELLNERVQIGTFPWRFRGGESSVCRCVAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT17</accession>
    <name>A0A3N6LT17_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin-like protein CetZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cetZ</name>
        <name evidence="8" type="ORF">EA462_02770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in cell shape control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CetZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93143">
        <property type="protein sequence ID" value="RQG93143"/>
        <property type="gene ID" value="EA462_02770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01946">
        <property type="entry name" value="CetZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032907">
        <property type="entry name" value="CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="386" mass="40992" checksum="58889AD407B43C75" modified="2019-02-13" version="1">MQLEVIGVGGAGCRIAAAILEVDPADHSFVADVFAFDTDSACLDEVTSIPDPYRHRYGETIESGLNGNLQRGRSVGNEYVEELSRRLDRGRPAVADAFLVAVGLGGATGGGTIPQLVENLQTLYDAPVYVLATLPAERELAPPSDGGSDAGNEPTARPMAEENATRTLEELDGTADAVLCFDNERWLKTAETMADARDRLNRELATRVATFFSATADATEEGEVTAAETIIDANDVGRIFGNETGIATIGYGKQRIETDSGGSRFGLGLFSAEPSVETSEAVSAIETTIGKALRDRLTLECEPENAARAMLVVGGPPAWLNRRAIADGRRTIEEATGSVEILGGDAPRPESDVVFAVVVLAGVDPVERLEAIRSRTTPLDRDRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LTB4</accession>
    <name>A0A3N6LTB4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93273">
        <property type="protein sequence ID" value="RQG93273"/>
        <property type="gene ID" value="EA462_00190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="85" mass="9772" checksum="2FBE049637C4BCB6" modified="2019-02-13" version="1">MTESMLEEIERRLSRARDLEAQEAVSLLRTARADLRDRESDPDVDEERRAALETRLEQRIREIENREAYDGGLGAAMNPDDDDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUI0</accession>
    <name>A0A3N6LUI0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S28e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps28e</name>
        <name evidence="4" type="ORF">EA462_04280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91214">
        <property type="protein sequence ID" value="RQG91214"/>
        <property type="gene ID" value="EA462_04280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_S28e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="PTHR10769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="74" mass="8014" checksum="C2310236E4E6443B" modified="2019-02-13" version="1">MSAEEEESSSTPAEVIEIVGKTGMHGEAMQVKCRIKEGENQGRIITRNCLGPVREGDVLQLRETAREADSIGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUL5</accession>
    <name>A0A3N6LUL5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91254">
        <property type="protein sequence ID" value="RQG91254"/>
        <property type="gene ID" value="EA462_04490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="595" mass="63532" checksum="5FE7C3278CDC2393" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV42</accession>
    <name>A0A3N6LV42_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ISH3 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91524">
        <property type="protein sequence ID" value="RQG91524"/>
        <property type="gene ID" value="EA462_06065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="388" mass="44400" checksum="CF47E51CCEF4F623" modified="2019-02-13" version="1">MFNPTQADGSIHEDQVLNFLVNTIDEEVELDLALNAKTTSEDVHEVLVGTCADGTSVSTLCEKSEDSPHHNTVLYHLREKFDLESVERIGNTLLQKDVLDVLPEQVEVCADLHLRPYYGDEDETDGLYHSEAKRGTTAFHAYATLYARVTNKRFTLTVRRLEDGDTASCVLAEFLGVLDGLDFSVKAVYLDREFYDSKCLTLLQAPNYAYVMPIVRWGKTIKQELSEGWSRVIQHDLTGKLDGPAVTVEFPVYIDCAYQNGRYNEHGVARHGYAADAPFIDTPRDARYHYAKRFGIEASYRLSEQSIATTSTQDPVVRLLYVVVSLLLQNVWRYLHWEYVATPRRGGRRLWSWPFKEFINMIRRAAWTSLAVRRAVPTNRPPDDRFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXW8</accession>
    <name>A0A3N6LXW8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rps12</name>
        <name evidence="6" type="ORF">EA462_00035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92664">
        <property type="protein sequence ID" value="RQG92664"/>
        <property type="gene ID" value="EA462_00035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_A">
        <property type="entry name" value="Ribosomal_S12_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022863">
        <property type="entry name" value="Ribosomal_S12_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_S23_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="142" mass="15429" checksum="C04496C88C8930A9" modified="2019-02-13" version="1">MANGKYAARKLKKDRQNQRWSDSDYARRARGLREKSDPLEGAPQARGIVLEKVGIEAKQPNSAIRKCVRVQLIKNGKQVTAFCPGDGAISFIDEHDEVTIAGIGGAKGRAMGDLSGVNYKVDKVNGVALLELVRGNAEKPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY12</accession>
    <name>A0A3N6LY12_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_17055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86178">
        <property type="protein sequence ID" value="RQG86178"/>
        <property type="gene ID" value="EA462_17055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="552"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="130"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="427"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="631" mass="66736" checksum="9D45A4BDC19D3211" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY73</accession>
    <name>A0A3N6LY73_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92794">
        <property type="protein sequence ID" value="RQG92794"/>
        <property type="gene ID" value="EA462_00765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="188" mass="19682" checksum="D5FA4B419AA7C7B1" modified="2019-02-13" version="1">MSSHSNGPTTYGFGGSLNWLLGSAVGGIIGSILFGAVLWIVDPAIVTETIPAIYGIDPGTVGLVFHLIHGTVLGIIFGFIVSRNPIFSTITADATTGLFAGRGLTTRFALAGLVYGLAVWAFLPIIVQSIWIAFTGIVDPGFPFAAFESLIGHLLYGLLLGALFAVFVETAPEAEETESPFDETSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYH3</accession>
    <name>A0A3N6LYH3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86782">
        <property type="protein sequence ID" value="RQG86782"/>
        <property type="gene ID" value="EA462_16745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="220" mass="24481" checksum="EA9768411C00DE34" modified="2019-02-13" version="1">MDQGTNLPHEGDADPTEPTDCCKVGRVALAFDVTEAVTQLARDRRSGDSYRTLAEQFNKDLIESALERADIESDRSIHAALVGDDIATEVYRLFRTDSDSDVRRAEVRARLSDAGVDVDRLESALVSHVTIRSHLTECVTVEVDESPPSFERTVNTTQWAHTRASNVIQSTLDRAVDHGHLRTGPLEAELSVRVTCTVCGDSFYLTDLLDQRRCSCHHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYP1</accession>
    <name>A0A3N6LYP1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-phosphosulfolactate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_12985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23416"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15597"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58738"/>
            <dbReference type="EC" id="3.1.3.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ComB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.71" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87783">
        <property type="protein sequence ID" value="RQG87783"/>
        <property type="gene ID" value="EA462_12985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050532">
        <property type="term" value="F:2-phosphosulfolactate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005238">
        <property type="entry name" value="ComB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036702">
        <property type="entry name" value="ComB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37311">
        <property type="entry name" value="PTHR37311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04029">
        <property type="entry name" value="2-ph_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142823">
        <property type="entry name" value="SSF142823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="249" mass="26691" checksum="066191B4AC67899A" modified="2019-02-13" version="1">MAEATYQLDGPLAEATIPSQTSIPSDPEPGTYVVIDVASFSTTVVELLNNGASYIHITDERGDEFGFRDEHPEAKIGGGKTDDYEPTEGYDFYNSPSYVQSVDVDGRPVAMTSSNGGAAVTDLDTRGGDDVEIYISSMTNAKAIADHLRADDAETIAVIAGSNGKPSPEDAAGAILFHRYFEENPPTEPELEMLKTVVTSGKASKYHDQPDIKHRDLLEYCSAVNTRSVIPKLEDGALVDVAGNGAERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYY8</accession>
    <name>A0A3N6LYY8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87923">
        <property type="protein sequence ID" value="RQG87923"/>
        <property type="gene ID" value="EA462_13760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="118"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="312" mass="34982" checksum="03C5AA3260637DB1" modified="2019-02-13" version="1">MHTMESFETVVPNYSVPPAGRSSSIQTQHESLNDMSTKSLNSVRTKWENALMSVKSRLAGTWFERNRGLLIRLFAVFVGLTIWDLYARGQPDYLFPGLELIFESLVTQFREDDLVGAFMNSMGTMFLGYILAVLVGVPLGLAMGINRHLDVMLNPYINAMYVAPISAMVPIFILIGGPTFEVRVFIVFLFCVFEILIDTYEGVKTTPEGLLEVSESFGASKYYTVRHVIFPHDLPYITAGLRLGMGRAVNGMILAEILIEFVNLGGIIRSWADVFRVSGVLSIVLLLMLVSIILTRLIQLLEKQIIDWEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZV9</accession>
    <name>A0A3N6LZV9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88860">
        <property type="protein sequence ID" value="RQG88860"/>
        <property type="gene ID" value="EA462_10700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="251" mass="26733" checksum="BC00CC23E25AC8A2" modified="2019-02-13" version="1">MEEADSCRRAAFEAVADVEPPQLHDLVESVLANASMIPGVLTIESAARATTPPLENAADEADFESVEIDTEGIYTHAAGVQLIYEGLGLTRTLAHDEPWTATSSEPIAAEADLEILAADILVARGFYLLARTDAAGKAVRTVQSFGRDQTHLEDLRRDDGQKVDARPSQSDPAAIDANLERDVLELAVRAGAAAVEEPPSPRLLALADELAGDVAPSFPPVEECLNDFSFSPSDRSLEEPTTDRATSATDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0C2</accession>
    <name>A0A3N6M0C2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpB</name>
        <name evidence="10" type="ORF">EA462_11825</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89060">
        <property type="protein sequence ID" value="RQG89060"/>
        <property type="gene ID" value="EA462_11825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005724">
        <property type="entry name" value="ATPase_A1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01041">
        <property type="entry name" value="ATP_syn_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="9">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="8">
        <location>
            <begin position="129"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG89060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="472" mass="52329" checksum="4ADA6A075757CB2F" modified="2019-02-13" version="1">MKEYQTITEVSGPLVFAEVDEPVGYDEMVEIETPSGDTLRGQVLESSDGLVSIQVFEGTGGIDRNASVRFLGETMKMPVTEDLLGRVLDGSGNPIDGGPEIVPDERIDIVGEAINPYSREYPEEFIQTGVSTIDGMNTLVRGQKLPIFSGSGLPHNELALQIARQATVPEEEEGDDEDGSEFAVIFGAMGITQEEANEFMQDFERTGALERSVVFMNLADDPAVERTVTPRLALTTAEYLAFEKDYHVLVILTDITNYCEALREIGAAREEVPGRRGYPGYMYTDLAQLYERAGRIEGREGSVTQIPILTMPGDDDTHPIPDLTGYITEGQIVMDRDLNSQGIEPPINVLPSLSRLMDDGIGEGLTRADHGDVSDQMYAAYAEGEDLRDLVNIVGREALSERDNKFLDFADRFEDEFAQQGYDTNRSIDDTLEIGWDLLSTLPKEELNRIGEDLIEEHYREEEVEQVETTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0F7</accession>
    <name>A0A3N6M0F7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88034">
        <property type="protein sequence ID" value="RQG88034"/>
        <property type="gene ID" value="EA462_14380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="249" mass="26862" checksum="F363AA0D0C0694DE" modified="2019-02-13" version="1">MDVGLTVGDSIERMERTIEGYDFAELSIAEGTETDEIDADRLEAVLDDAGAELCVHLPFKQVVVTPVTEINDAIRTYQTRLLEWAGSAGATKAVLHGTARNPHNTDLRPVFADQLEALGAAGADAGVELVVENVGHQKRGLQLTVLGDIARETETSVCFDVGHAYMEDGDDGVDRFLSRYGDLVSHLHVHDARSRGDTHIPIGAGEIDYDVVTKHLAGFDGTVALEVFTDDAALLRDTARRATAALEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0K7</accession>
    <name>A0A3N6M0K7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89170">
        <property type="protein sequence ID" value="RQG89170"/>
        <property type="gene ID" value="EA462_12445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="156" mass="16913" checksum="2D76C25D73AA3CD7" modified="2019-02-13" version="1">MLYACNQANGRTKLSDVAEQVAAWEYGKPIDEITSTERKRVYTSIQQHHLSKLEDAGLLEVANGNIRITDKAENLDVYLEIVPEKNIPWATYYLGLAAIGAFSVGIAHVGWLPDAVSVSVVAALFASVLAVSAAIHSIESRQMTFSAADVPPEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1K5</accession>
    <name>A0A3N6M1K5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88981">
        <property type="protein sequence ID" value="RQG88981"/>
        <property type="gene ID" value="EA462_11365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="207" mass="21749" checksum="B6C2B62FC72E9B29" modified="2019-02-13" version="1">MDAPTQEVTTMVDDPAENVDSVEGTAATDGEEPETDGGVRAYTVRLELVDEPGELLRALAPISENGGNLLSIHHERGNITPRGHIPVEVDLECPPDRFDDIVGALRDAGVNVIQAGAEHYGEEISVVLVGHLVESDLSDTLSRIEADVDAVLLDLSLAAPDGTDAISSARARLAIDSGRSDEALEAIRAIGSEKELTVVEPLLGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M283</accession>
    <name>A0A3N6M283_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89910">
        <property type="protein sequence ID" value="RQG89910"/>
        <property type="gene ID" value="EA462_07825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="116" mass="13461" checksum="28B7AEA2DB1F9F39" modified="2019-02-13" version="1">MDDEVPIEEILNTIGDEHARTVLASISREPGSAKELAERLDLSQPTIYRRIDLLQEYDLIKERTLVADDGNHYNEYTSNFNSTVISLEGDEYDVRIFREENLPDRFSRLWDDLGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M399</accession>
    <name>A0A3N6M399_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90340">
        <property type="protein sequence ID" value="RQG90340"/>
        <property type="gene ID" value="EA462_10220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="129" mass="15153" checksum="D58BA5BC5F2A91E0" modified="2019-02-13" version="1">MSARKFLRFQCHEFDAHFHLVREALKPYYALTDVRKNHDWATNGKPTGTFESGGETWRVCLDYDEQPILPWSDPSYRLETAYLYRIYFVCEDVDTLVRAARRVLERNDLTRAVTFGVETSVNVIRKGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3C4</accession>
    <name>A0A3N6M3C4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90370">
        <property type="protein sequence ID" value="RQG90370"/>
        <property type="gene ID" value="EA462_08855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="50"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="223" mass="25657" checksum="5FC90357C94ECE4D" modified="2019-02-13" version="1">MGVEIKENRVPDVEFEEMKGFVFEYLSASVEKEEEGGRMRWYPWHSAEYRHNHILNVVDLAEEIANKEGADVDVTRVAALFHDVAKLETDQELHAEAGARIAREYLESRSEYPESFIHQVCRAIEHHSYRGDLEDLSLETQSLIEADLLDKIGANGTALMLLRMGYEARTHMDADEMVERVLDRGYDAASRVESDTAESIAHQRLKRVKWFQEWLEDEIAGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3P0</accession>
    <name>A0A3N6M3P0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89821">
        <property type="protein sequence ID" value="RQG89821"/>
        <property type="gene ID" value="EA462_07325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="74" mass="8201" checksum="E0404D39FB4CE7C7" modified="2019-02-13" version="1">MPKVEITIPEHLEMQIAQMVERGEFVNREEAIEDLLSTGIKAYKTSGPMDEEDGAGGPGLEDDGMMGHDDEYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4F2</accession>
    <name>A0A3N6M4F2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87037">
        <property type="protein sequence ID" value="RQG87037"/>
        <property type="gene ID" value="EA462_15465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="100" mass="11472" checksum="F0503840EB0419CF" modified="2019-02-13" version="1">MGFDDITEALGGRARRQVLVELQDHNPVDQPEAVTKNSAQEDEVQELQLTHTHLPKLDDMGYIVWDRDHGTIIKGPNWEEIEPVVRLLSDNRDQIPNDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4L9</accession>
    <name>A0A3N6M4L9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Right-handed parallel beta-helix repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90181">
        <property type="protein sequence ID" value="RQG90181"/>
        <property type="gene ID" value="EA462_09335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="221"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="742" mass="79636" checksum="2C2E6C4664036598" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M534</accession>
    <name>A0A3N6M534_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fructose-bisphosphatase</fullName>
            <ecNumber evidence="2">3.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_13075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87799">
        <property type="protein sequence ID" value="RQG87799"/>
        <property type="gene ID" value="EA462_13075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="273" mass="29997" checksum="78A9D470C87994CB" modified="2019-02-13" version="1">MIDDEYLQTAVDAAEKSATILSENFDTEFDVEHKSPTDMVSEIDIKCDRVIKEHIRERHPDHSFFTEESGADGDGSYRWIVDPLDGTHNYVNSFPYYCVTIALEIDGEIHAGVINRPEMNEVYTTVRGKGAYCNGEEIAVSDTERLTGGFLGMGISPPAATDEEFLELFKRLIGNPVRTEGVRRLGCGAADLSLVGQGTLDGVFDKYTSPWDVAAGTLLVEEAGGTVTDLNDEPLDFSAGERELHIVATNGEIHDAILDQYERASNSVAVKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M662</accession>
    <name>A0A3N6M662_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_06105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91530">
        <property type="protein sequence ID" value="RQG91530"/>
        <property type="gene ID" value="EA462_06105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="30"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="363"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="396"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG91530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="600" mass="66839" checksum="26D429D4A7AB8013" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6R2</accession>
    <name>A0A3N6M6R2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome partitioning protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89016">
        <property type="protein sequence ID" value="RQG89016"/>
        <property type="gene ID" value="EA462_11580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="234" mass="24896" checksum="69231186BE03D39D" modified="2019-02-13" version="1">MIVAISGGKGGVGKSTVAMNLARELEAIVVDADLTAPDLPRGRAVDLHDVLAGRADPMDAVVHHGSLCILPCGRTLAGARASDLAEMGRTVRRVERDYGDVVVDCPAGLARDVGTALHCADVAVLVTTPNRPALLDAVRTRRLALDLETPIAAVVLNRSRNGRGAQIDGRVEATFEAPATVVPERAAIADATRAGKPVRDVRPTDRVLEVFERIARQLERCHRRRADDGSLSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6Z3</accession>
    <name>A0A3N6M6Z3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_12090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89106">
        <property type="protein sequence ID" value="RQG89106"/>
        <property type="gene ID" value="EA462_12090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="109" mass="12395" checksum="1EC346C768628895" modified="2019-02-13" version="1">MELWGWLIGYVVLFALLHLILYVVYARRNDGETTGSPSFADPNRARSRTSPEPDRYSRVRDEIGDHAPDAPDDDRELDGETVRCPHCGATNAADQTFTYCWHCVSTLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M754</accession>
    <name>A0A3N6M754_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91171">
        <property type="protein sequence ID" value="RQG91171"/>
        <property type="gene ID" value="EA462_04035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="188" mass="21468" checksum="D511311DEC8A1621" modified="2019-02-13" version="1">MRGKRSEAIEIGDEAKHTDDWTDEMPGVDRVISVALTIEQPRTADWIAEQAAVSPTTARSHLERLVDLHILSAVEQRGAKTYYPDAAYQRFKEVSQLIEEHTRNEIETIAVTAKEDIEELRETYDVESPDELRKLATAEDTSSTEAREYFKKASEWDSHLHTVSIAEEALERYEKFSDHYQPSVDSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7F4</accession>
    <name>A0A3N6M7F4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89296">
        <property type="protein sequence ID" value="RQG89296"/>
        <property type="gene ID" value="EA462_12835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01011">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="401" mass="43847" checksum="6A2433CD8516EDE9" modified="2019-02-13" version="1">MWTRSTVHATADRIAVGEWDGTVTTLDPNSLEPRWSVDHPDHAVGIETLEPTGTVVVAGRGETGSIVAYDAETGEKRWQYDTVEDVGRAIDDTIFSQPYVVAIETDDGGDDVGCYAAARRYERDGETRQWHSTVFAFDSDGTVRWRYETDGSSISIDLDDTGERLAVGYNRCPGGHDHGLVVLETATGDPEWAWDPGTPGDRRVGDVSFDGDSIAAASHGDKRGYLLGPGGTEQWRVDLAVETELDGETLYAYPNHVYASDGRVAFVTGNTYATESRETENRHPNEHRLMTFDAGGDRLWDAEIRGFAHGIDADDGTIVAPCAQNFRVRDPETHAVRWFDLGTGVGGIQRLEGIATAAAIDGRTIATIEEPVEYHDETCVRGDYALQLTPLTDLPEPTPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M953</accession>
    <name>A0A3N6M953_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_00800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92800">
        <property type="protein sequence ID" value="RQG92800"/>
        <property type="gene ID" value="EA462_00800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG92800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="91" mass="9538" checksum="B54D8BA7E6F3191C" modified="2019-02-13" version="1">MSSIRRLLKGLFASVVGIVVIGLLATVVFAVTIFVVSTGASLAGYEPSADYVVIAAALIVVSVILTGGFTPRLSGRSDDEDGDRFDDRTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9L9</accession>
    <name>A0A3N6M9L9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92990">
        <property type="protein sequence ID" value="RQG92990"/>
        <property type="gene ID" value="EA462_01900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="597" mass="64401" checksum="0FAF5079D137924B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBX7</accession>
    <name>A0A3N6MBX7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92981">
        <property type="protein sequence ID" value="RQG92981"/>
        <property type="gene ID" value="EA462_01840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="70" mass="7894" checksum="CFEE35060C538FDB" modified="2019-02-13" version="1">MSDERLTLVLDRRFRLERDRSGSKPGLERREFDPSSLPFRLEFSPSDTDCCNDLPLGPQTGRGPTGNGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCM1</accession>
    <name>A0A3N6MCM1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="14">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="14">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">metG</name>
        <name evidence="19" type="ORF">EA462_05855</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="14"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91486">
        <property type="protein sequence ID" value="RQG91486"/>
        <property type="gene ID" value="EA462_05855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14 16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 14 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TRNA-binding" evidence="18">
        <location>
            <begin position="605"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="559"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="14">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RQG91486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="703" mass="78658" checksum="7F08BD68F912F2D8" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCT4</accession>
    <name>A0A3N6MCT4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91566">
        <property type="protein sequence ID" value="RQG91566"/>
        <property type="gene ID" value="EA462_06320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="62" mass="6905" checksum="2BD2C620D13731A2" modified="2019-02-13" version="1">MESEHSSVAVVEAVAAATNRDLFSIPPLYEQVDPDALDRLVTAAETDAQRTLHVSFRYEGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFR7</accession>
    <name>A0A3N6MFR7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-phosphooligosaccharide-protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Oligosaccharyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">EA462_00550</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92756">
        <property type="protein sequence ID" value="RQG92756"/>
        <property type="gene ID" value="EA462_00550"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041154">
        <property type="entry name" value="AglB_P1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026410">
        <property type="entry name" value="OlisacTrfase_arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="PTHR13872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18079">
        <property type="entry name" value="AglB_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04154">
        <property type="entry name" value="archaeo_STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="AglB_L1" evidence="18">
        <location>
            <begin position="814"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="927"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="927"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RQG92756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="988" mass="108808" checksum="77FE408D5DE90B66" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTX9</accession>
    <name>A0A3N6MTX9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_10550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88832">
        <property type="protein sequence ID" value="RQG88832"/>
        <property type="gene ID" value="EA462_10550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="271" mass="30908" checksum="BE851E7A2083AEAB" modified="2019-02-13" version="1">MVRQYYVPQVTELSEEELQAVFRVAEPPVCLLGGWAVHLHVNQGFQREHGRGYIGSRDIDLGIHVEPDWTAEEYDDTGVGKTLAGIEELGYEKSRFGFVQNFDRETGERISESEAKEYGMHEVFQVYIDVIPDTTELDSFREQYGFTPPAETLLKPVFEGGVGVPLSEYVSWEAPADVFIVAPELLAAMKIRSLPDRDKSHKRVKDAADLHALLWYTKDYQEMKDGVQQYVTEYDLNQLEAAINEELFENTAQLLQIEPTPVSGSIRRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWH5</accession>
    <name>A0A3N6MWH5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-pyruvoyl tetrahydropterin synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_07385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89832">
        <property type="protein sequence ID" value="RQG89832"/>
        <property type="gene ID" value="EA462_07385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG89832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="162" mass="17553" checksum="816A240EA7BAD538" modified="2019-02-13" version="1">MATDFSEDGVDVSTDSQTAGLPVAGTRRVLHIGRDRPIRVSAGHRILHHDGKCSRPHGHNYELTVTIAGTLTDEGWVVDKSEVTEVIDQWDHMFLLERGDPLIEAFSAAGDEDALVVLEHPPTAEVMSLVLEDRLESELPGNVSEVAVTVSETSELCGGSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWX5</accession>
    <name>A0A3N6MWX5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 13">DNA ligase</fullName>
            <ecNumber evidence="13">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lig</name>
        <name evidence="16" type="ORF">EA462_08270</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="13"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89992">
        <property type="protein sequence ID" value="RQG89992"/>
        <property type="gene ID" value="EA462_08270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="344"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="13">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RQG89992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="572" mass="61990" checksum="6A26D50C3E9FF35F" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWY8</accession>
    <name>A0A3N6MWY8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90002">
        <property type="protein sequence ID" value="RQG90002"/>
        <property type="gene ID" value="EA462_08320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="254" mass="27824" checksum="29CA48673804226C" modified="2019-02-13" version="1">MDWQTLIDEPAVIAAAVLALGLVVGYLVGRLNRELLTASGVPEAVEGTPFERTAQSIGTSTVDIVARLSSWFIYGIAVLTAIYIAQLLDTDAFAFRIVEFIPRAFIAVLVLILGFIVADKSELVVSEYLRGVKLPEVSVIPKLVKYSVLYVAFVIALGQIGVFVYPLLILLVVYAAGIVIVGTITFKDFLVSSAAGIYLLLNQPYGIGDRIRIGNQAGIVQEVDLFVTKIEDDSEEYIIPNRKVFEEEIVRIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N043</accession>
    <name>A0A3N6N043_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pyrB</name>
        <name evidence="9" type="ORF">EA462_04375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer of catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91232">
        <property type="protein sequence ID" value="RQG91232"/>
        <property type="gene ID" value="EA462_04375"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="150"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="311" mass="34158" checksum="68DA1D4AC36417C0" modified="2019-02-13" version="1">MRHEHLITSKQLSRADIETVLDHAAAIDADPEIVAGRHAGTLLGLLFFEPSTRTKMSFETAMKRLGGDVVDMGSVDSSSVKKGETLADTVRVIDGYTDALVLRHPKQGAATMASEFVDVPLLNAGDGAGHHPTQTLLDLYTIRENAGLDDLTIGIMGDLKYGRTVHSLAYALTNFDAHQHFISPQSLRLPREVVYDLHQAGDGAGVREHETLEEILPSLDVLYVTRIQRERFPDENEYQQIAGEYQIDLETLSVAGDELTVMHPLPRVDEIASEIDDTEYAAYFEQAHNGVPVRMALLDLLLESNGGDTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0T6</accession>
    <name>A0A3N6N0T6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91532">
        <property type="protein sequence ID" value="RQG91532"/>
        <property type="gene ID" value="EA462_06115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="124" mass="13940" checksum="D92FA8A653471502" modified="2019-02-13" version="1">MSNDESRGRKRPDRPENRTRADDHPPKPTNRTTYDGCLDAIDRLTAAVLTDVRVDDDLKKSDLERHLREIRAEVECARQKLPGDGITTDVPMVRRGGRGVTSWLGPDPSAFERFVGDDRTDNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3H0</accession>
    <name>A0A3N6N3H0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92662">
        <property type="protein sequence ID" value="RQG92662"/>
        <property type="gene ID" value="EA462_00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043940">
        <property type="entry name" value="DUF5781"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19093">
        <property type="entry name" value="DUF5781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="251" mass="28014" checksum="BA46F5E2ACF3189A" modified="2019-02-13" version="1">MDIRVQGPGPTAPFLSARDLFETEHDLSLPVYVQLQDDPDERTWAAHDDDRHVLNISRQAASSAMARELALHEFSHMARHEQDHPSHTQSLEEVLYLALAGRRVERRKLSHCYQIANHMKDIYADDITLSVGPGEKLLAFLESRLAMAVADRPETPTRAGLERLSPSADPEITVVNAAFALALAERHDLVGDDHRLYDLAHAAAMDAPDVDFEGFKHRFRELGRETDSSTYRQVLVDATRAYVGGEGLAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3T2</accession>
    <name>A0A3N6N3T2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92802">
        <property type="protein sequence ID" value="RQG92802"/>
        <property type="gene ID" value="EA462_00810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="475" mass="49134" checksum="1F49DDF9F7344957" modified="2019-02-13" version="1">MTGWQAAAVASLARVLERFGIIDAERFRPTMNLAWPRIITGFAITSKQTADLAMVGLAVGTAGTAGLAFALAYWGTVTMLGLGLAGGTVSLVSQNYGGDDAERASVVVTQSVFLTVAFAVPIMLVFLTFADSFIGLLGADPTSLGHGSTYLVFVAPAVVFEMLNLIASRTYTAVGDTFTEMVVRAGGAFLNIVLSGILIFGFGLGVAGAAIGTSVSTGIVTVILAWGMIGRSYGGLGMKPSPVPISRSSLSLEPAVIRQLVEISLPEIGRRLAQGVVVFPLLWIAASFGPVIVTAIEVGRRVRDLSNSVNWGLSLASSSLVGQHLGAGEEDEAGAYGAGIIRLSVVVYSALAIVVIVFSEPIASVFVSDPNEVAQAGVFVAIGAISAVGMGIDGTAAGALLGAGDTRLPFLASLIGRYVFALPAAALGLVTPLGVAALYLALLLETYVPGGINYWLFRRGRWKVVSRRYRPSSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N4G4</accession>
    <name>A0A3N6N4G4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Four-helix bundle copper-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93072">
        <property type="protein sequence ID" value="RQG93072"/>
        <property type="gene ID" value="EA462_02375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08026">
        <property type="entry name" value="DUF326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044543">
        <property type="entry name" value="YHJQ-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="114" mass="12874" checksum="AD408286AAAE2B05" modified="2019-02-13" version="1">MALQRIDHADDHMQRCIDNCLEAAQVCEWCADACADEEGMARCIRLCRDVADVTTLHARWMARNSGYHRELAAICADLCEECAEECERHDHDHCQACADVLPDCVETCREMAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N526</accession>
    <name>A0A3N6N526_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93322">
        <property type="protein sequence ID" value="RQG93322"/>
        <property type="gene ID" value="EA462_03075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027034">
        <property type="entry name" value="OMS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF60">
        <property type="entry name" value="PTHR42912:SF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="41"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="202" mass="22880" checksum="EB1421B342E93D11" modified="2019-02-13" version="1">MSTKDIQTAYAKYADLVDRMEWFDRLLIGRYRRKQFENIDGRVLDVACGTGTNFRHLSETIELVGIDISPEMLAKARERRDQLNLDGELHRMDAQALEFPDDSFDAVISTLSTCTFPDPIAALQEMERVCKATGQILLVEHGRSSVELIARFQEWRADSHYNKMGCRSTQEPLEHVSKAGLPILKTESGMFGIITTVEAQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NU12</accession>
    <name>A0A3N6NU12_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_17155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86196">
        <property type="protein sequence ID" value="RQG86196"/>
        <property type="gene ID" value="EA462_17155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="390" mass="42429" checksum="8E6C9DB22AA00613" modified="2019-02-13" version="1">MGALSNLRVLDLTQVLAGPYCTMLLADLGADVVKIERPGGDLIRSNPPFVSDPGEEAYGGYFQSVNRGKRSVELDFREERDRADFLSLVETADVVAENYRAGTMEKYDLGYETLSERNPALVYSSIRGFGDPRTGETDRQGQPSFDLIAQALGGVMEITGQPDGPPTKVGPGIGDLFTATLNCIGILAAITHRNRTGEGQYVDTGLYDAMISMTERAIYQHSYTGSAPTRRGNAHPTLFPYDAFETADGHVVIAAFGTNHWLALCESMDRTDLAEAYPTAADRLESRATLRDEIADWAIRRTSAELVATLEGHVPAAPVQTTDDIFDDPHVRTRELLVSVEQPGADTEVEIAGTPIKMTETPPEPGGRAPLLDEHREELLGEDLETAIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUB3</accession>
    <name>A0A3N6NUB3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86740">
        <property type="protein sequence ID" value="RQG86740"/>
        <property type="gene ID" value="EA462_16530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="216" mass="23961" checksum="B99811AC350AF2BC" modified="2019-02-13" version="1">MTRAVLFDMDGVLVDSEPHWKRYWQTEVFPEAVDGEPTLEDVTGRNFRESLVALDETYGLPGGPDRFEAEVEAFAERMYRERATVTEGMPALVSSLQDRVSSFGIVSSSPRRWITLVVDRSDLSAPDVIVSAEDIEAPGKPDPAIYEHALERLDVDPFDALVVEDSIHGARAASRAGTTVVRYEYGGDPEPIPEAEYVADDLPQLRTLLFELSADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUV4</accession>
    <name>A0A3N6NUV4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87010">
        <property type="protein sequence ID" value="RQG87010"/>
        <property type="gene ID" value="EA462_15305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="104" mass="11166" checksum="4FC078B80C1D7B80" modified="2019-02-13" version="1">MIDPNYIGAAVWFVCGLAILGLGYLIGVHGRADLHADYDESVDPTYASRWIGVTAVVMGLLVIGYAVREAIYGFHPYALGGLVLTLLVLSYVTKLFARGFGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYN5</accession>
    <name>A0A3N6NYN5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_17020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86172">
        <property type="protein sequence ID" value="RQG86172"/>
        <property type="gene ID" value="EA462_17020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="291" mass="33273" checksum="B5C984E29EA9E645" modified="2019-02-13" version="1">MGHVYYHHPGDKQFSLDYITQTPEEVVSQITSYRDDVSVKVSEYDLDEHFYAIYTSRGGGKPVSELELDVSEALEQLEAENGQIVARLLETYRALIQRNEEEEGSPVIAYKDPDIEALGEVLDRVSWTGSATDVAGRLSSNLILKHALPNANHRAAVAVIQVYLRCYDPDFSLPETKGEAGPNEFDWQDWVNAYINESKRILTVRRKNVIFKILRQFGATTVERKHNVEIDLTSYTLDLYPSEAKKRYAEEHEQLWISFVEEVVERVERSDLKDTPALSKSAFAEEIRNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYW5</accession>
    <name>A0A3N6NYW5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_16110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86666">
        <property type="protein sequence ID" value="RQG86666"/>
        <property type="gene ID" value="EA462_16110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="423" mass="45106" checksum="324FE95BBEA4BFC0" modified="2019-02-13" version="1">MDRAGEANSIYDELGVPPVINATGTKTRIGGSRIRTGAIDAMNRASESFVRLSDLQAEASARIAEITGAQAGYVTSGAAAGLLLGAAAALAGHDIQRMDRLPETAGIPDEIVMPRTHRTGYDHAFRATGATIVDVGTNDRHLGTGSTNVEPWEIEAAITAETAAIGYIEKPYTGPPLGVVTEIAHEHDIPVIVDAAAELPPTTNFSRFIDDGADLVVFSGGKAIRGPQTTGIVAGRKDLIQSMALQHLDMHAASEVWEPPERLIDLEEIDGVPRQGIGRPMKVGKEELVGLIVALESFLEEDQAETNRGWHERAVRISEELSKIEGIKTTVTVGNDVSVAPETIVRIDPDEAGISASELVRALRSENPRVFVGADRLDENVVTINPMCLEDGEPGYVLDRIWAHAGPESDEPVSERDVANTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYY9</accession>
    <name>A0A3N6NYY9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-aspartate dehydrogenase</fullName>
            <ecNumber evidence="6">1.4.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadX</name>
        <name evidence="9" type="ORF">EA462_16280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:11788"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:11784"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the L-aspartate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.21" evidence="6"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86696">
        <property type="protein sequence ID" value="RQG86696"/>
        <property type="gene ID" value="EA462_16280"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033735">
        <property type="term" value="F:aspartate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01265">
        <property type="entry name" value="NadX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002811">
        <property type="entry name" value="Asp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022487">
        <property type="entry name" value="Asp_DH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020626">
        <property type="entry name" value="Asp_DH_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011182">
        <property type="entry name" value="L-Asp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01958">
        <property type="entry name" value="DUF108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005227">
        <property type="entry name" value="Asp_dh_NAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03855">
        <property type="entry name" value="NAD_NadX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_3" evidence="8">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF108" evidence="7">
        <location>
            <begin position="173"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG86696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="274" mass="28134" checksum="921E377D58033F74" modified="2019-02-13" version="1">MTRSIGIFGCGTIATEIARAIADGTLSADLAVVYDRHPENVTAIRDLFDDRSQPTAATQPSELLEADLVLEAAGQTAVEEIAADALAADRDCLLLSVGALAADDLREDVFAAAEESDGRLYAPSGAIAGLDAIKAAALTGDLESVSLTTTKPPAGLEGAPYVVENGIDLSAVDEPTVIFEGPATEAAAAFPSNINVAVALSLAGIGPDETAVRIVADPDEENNVHRISADGDMGHIETTVQNVPSPTNPKTSYLAAISAIEKLRSLETAIDVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ03</accession>
    <name>A0A3N6NZ03_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86716">
        <property type="protein sequence ID" value="RQG86716"/>
        <property type="gene ID" value="EA462_16400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="348" mass="37749" checksum="8F9F5C9690615A1B" modified="2019-02-13" version="1">MPVRSGNGGRSHISRRAAILSSGAALTAGFAGCLDSNGETDDDTGNGDGSIPTITLGHGIAAEEPLWLMEVISDELDHWGEAYEAEFIPFSANDERLQAFQAGELQAGTAAAITTIFATESGLPMTVVANVSQCREETFTEEFLVTPDSDIDGLNEESLQDTRIGICAPRSSCDMWAQSAALQAGLEVGTDVEVVVTPFPSMPEAVNGGEVDTAMFPQPFHHTGINETGLEPVFDVIDSTGFEHDLMELWFSTQFLENNGDVVELFLEDYSTAVDRFNDDPESSLEMIAEAGYVETPTELYVDLPYYTYSASPMTESLEEINSLAVDIGWLDEEVSIDHLWDLSYLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0B1</accession>
    <name>A0A3N6P0B1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_13475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87868">
        <property type="protein sequence ID" value="RQG87868"/>
        <property type="gene ID" value="EA462_13475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="274" mass="30794" checksum="803D9C2DAD6446DC" modified="2019-02-13" version="1">MSENDTPSEMGALGTIRRLVVANNKFIFVQSILSFLVIWHVLANTFGMADTISSPSLVASSLYELLLTDDWYYHVYVTLRRSLYGFVFTIVVGTALGVAMGISPFFEKAFRDYVIVGLALPTLFAAVFSAMWFGLSDVTPMVAGALIAFPFITQNVYEGVKDVDQELVRMAHSFSVSRRRVLSRIVLRSIMPEWFSGARYSFAICWKVTTLTELIIAQNGIGYMIARQMSVLSLTGVITWTVLFMVIILVLEYGVFQQTEKIVFAWREKPVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1I3</accession>
    <name>A0A3N6P1I3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps5</name>
        <name evidence="9" type="ORF">EA462_05125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts protein S4.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 6">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91359">
        <property type="protein sequence ID" value="RQG91359"/>
        <property type="gene ID" value="EA462_05125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_A">
        <property type="entry name" value="Ribosomal_S5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_S5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="8">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG91359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="220" mass="23781" checksum="158C5173A1D84892" modified="2019-02-13" version="1">MSANDYNDDGWQPVTRLGRKVQEGEIDTMETALNSGLPLKEPELVDQLLPGLDDEVLDINMVQRMTDSGRRVKFRCVVVVGNRDGYVGYAEGRDDQVGSAIQKAIGIAKLNIIQVPRGSGSWEDRSDRPHSLTRRTSGKAGSVEVDVIPAPEGLGLAASDTVRAVLELAGLENAWTKSHGNTRTTVNLAKATFNALENASQSRLPRSVGADREDAEVADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1S9</accession>
    <name>A0A3N6P1S9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91499">
        <property type="protein sequence ID" value="RQG91499"/>
        <property type="gene ID" value="EA462_05930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="235" mass="24314" checksum="83C66D3FFF3151F9" modified="2019-02-13" version="1">MSDDRSPDHDGTEGDESTDDGQSGGGAPGGGPRRVVSERSVDDILSSLDETTGDTADDGDRTDELETSTDEAELPSDEPRAATSEPRAASDESRPTTETAPPSTVDGSEPTVDDTVDALKARIDSGDVTGSDVRAAETGGGRESTPEIDEIELSMDDLDTGESTAGPPSEVIGERASGAETIRDDRNRDRTDAVGGEAKTDASTAVSGDDADSDDDSSGDERTGLFGRIARLFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4E1</accession>
    <name>A0A3N6P4E1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetate--CoA ligase (ADP-forming)</fullName>
            <ecNumber evidence="2">6.2.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_09690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15081"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.13" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90245">
        <property type="protein sequence ID" value="RQG90245"/>
        <property type="gene ID" value="EA462_09690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="487"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="698" mass="73957" checksum="5B9EC763406F2A55" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4F5</accession>
    <name>A0A3N6P4F5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92819">
        <property type="protein sequence ID" value="RQG92819"/>
        <property type="gene ID" value="EA462_00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="149" mass="17233" checksum="B83CA5E8D9152084" modified="2019-02-13" version="1">MSDTQQQQEFEKTDPSREIGVDPEKHPLYKELENNPNSPFYEEELVDIWLFTVGYGRQHSEREPLPGNKKWMLRMTSLDDDEEWIVKSIAIEETGTTDVLQDGKQIFTIAQEYANSGIELVHEEVTDTDSDSISELTSDVVRTHRSQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4L4</accession>
    <name>A0A3N6P4L4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90345">
        <property type="protein sequence ID" value="RQG90345"/>
        <property type="gene ID" value="EA462_06990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="2">
        <location>
            <begin position="16"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="124" mass="13227" checksum="E6B08057A96C246A" modified="2019-02-13" version="1">MSTDSLDGGEAETRPTIEVTEDAADQALALLDGEGLDASEAGLRLFVQQGGCAGLSYGMRFDDGPDEDDTIYEHHELRVFVDPASLKYIGGSILDYESGLQAEGFNVENPNVVSECGCGESFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4N9</accession>
    <name>A0A3N6P4N9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92949">
        <property type="protein sequence ID" value="RQG92949"/>
        <property type="gene ID" value="EA462_01650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="140" mass="15610" checksum="8CE9A0F47B99AA3C" modified="2019-02-13" version="1">MTGDEDDASSPSERRDAAAEYETMADALEDLVVELRDEPIAESRLEGLFDEATTSDPRIWNTVTAFIDIEDGEAVVTDESKLAEGSWAPEIVDGCDAMVTVDVQRGLMPDEFTYVVGKELSERIDTFRERATEARRQTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P522</accession>
    <name>A0A3N6P522_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DJ-1/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93139">
        <property type="protein sequence ID" value="RQG93139"/>
        <property type="gene ID" value="EA462_02750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="8"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="198" mass="20607" checksum="C0BA9D87AD64581D" modified="2019-02-13" version="1">MVDITAEIVLFDGFDELDAIGPYEVLVNGAEAGASIETRLVTLEETDVVTASHDLRVEPHGTLGEPDLLVVPGGGWTTANEGVRAVVEDGILPGAVDERYTAGATIASVCTGAMILSEAGLLEGRPATTHHAAVDDLEATDATVVDERVVDDGDVLTAGGVTSGLDLALWLLEREFGADVANEVARQMAHDRRGSVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P5Z5</accession>
    <name>A0A3N6P5Z5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_03720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91115">
        <property type="protein sequence ID" value="RQG91115"/>
        <property type="gene ID" value="EA462_03720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="13"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="127"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="234"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG91115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="387" mass="42480" checksum="DDD4E8EB670F6DCD" modified="2019-02-13" version="1">MLDFVRLEADVGEEERLVRDTAREFVEDRVKPTIGDHFEEGTFPTELISEMGELGFYAPNLEGYGSPNVSETAYGLLMQELEAGDSAVRSMASVQGALVMYPISAYGTEAQKEKWLPRLGNGDSVGCFGLTEPEHGSNPAGMRTTAERDGSGYLLDGSKTWITNAPIADVAVVWARDRSSEGDPVRGFLIETDRDGVTTNEITGKLSLRASITGEIGLNDVTVPEENVFPDVSGMAGPLSCLTQARYGIAWGAVGAARDCFEQARTYALERDQFGGPIARFQLQQEKLAEMATQITLGQLLAYRLADLKERDELRSQHVSMAKRNNVRTARETSRRSREMLGGNGITTDYSPMRHMANIETVYTYEGTHDIHTLILGEELTGISAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6S9</accession>
    <name>A0A3N6P6S9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0104 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_06370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91575">
        <property type="protein sequence ID" value="RQG91575"/>
        <property type="gene ID" value="EA462_06370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="339" mass="34285" checksum="57B8948384070351" modified="2019-02-13" version="1">MRWRRAAGGLALAVGVVVLLVYGIGWETVTETVSEAHPGLLAGAILSGLCMLALRGLVVGRLLAPVQGGARGNAFVAAYLSGYFARSALPWGRSTGTPITAYLLAEGSNSQFEDNLAVVAAAEGFNAIASVVVAVTGFVVYTAASDSDALNAVSAAITVAGIVAVAATVLVVVVFNRGVARRVVARIAAGGEAILEKLPRVNDVRGRLTDRIDGFFDTLETIGASRRALAAAIGIAIASWVFNALPLYLCLLAVGVDAPLAVALVCAPLASFGGVVPLPGGSGGIEVVLTALLVATLGLPTGVAAGVAVLYRLTTYWTHLVIGGCVASAVSMVGMSRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P940</accession>
    <name>A0A3N6P940_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92745">
        <property type="protein sequence ID" value="RQG92745"/>
        <property type="gene ID" value="EA462_00490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="100" mass="10565" checksum="242BC20ADF9F4DD2" modified="2019-02-13" version="1">MSNNRVEQLESTVAELESTVDGLTSELIEAKERIRVLEAELDEETPTRVPDRRNGESESADKSDGTSEAAPDDVAEAAADADDGAGDEAEDSGTDDIIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PA56</accession>
    <name>A0A3N6PA56_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93215">
        <property type="protein sequence ID" value="RQG93215"/>
        <property type="gene ID" value="EA462_03205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="128" mass="14072" checksum="9D5F1D3111CC0D2A" modified="2019-02-13" version="1">MVLKRLLSGDPSKSSKLYLAIGVLSLVKAIAVRKDPNRFRRELLDAGLFLGVGIALRKYSQLKAQKRSEIESQLPNWLGDVGGSEGRFDSGSESTVTGFQSRAKERLQGRSEPEPSLRDRARGIVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LII3</accession>
    <name>A0A3N6LII3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Outer membrane lipoprotein carrier protein LolA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87009">
        <property type="protein sequence ID" value="RQG87009"/>
        <property type="gene ID" value="EA462_15300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="400" mass="44385" checksum="D4437CB00A9FE79D" modified="2019-02-13" version="1">MSPNTPARRFVVPLLVLGTIFLLAGCVAVPGDDGLETDLEQRFASEGPPDEIAATLEVRSSIDGETTVREENVWYRTDGTSRVESTDGTHVVVVDGQSRWSHDSETGSVQRLEIDPNQPSILDGLYTQQTRYVESDRYTLTEREETTIEGRETYRLVFDPPENETVERSVDVLVGDTEYVIPLETSERDIEDRGIERIEIWLDKETLFPVRHHLDGDEIELETTYRNLAVEPGLEDDLFEFDPSTVSGIGDGENGETSEDDAVEEIALPVIDHHETVEAATEAVPFAVAEPDRSSLPETVERDGIRSYEFPDENRTQVSLFYRDEDGTVSVTTSDGPREFAADGTEITVETATGRIEETDQGTELEWSCDGRHYSVFAADSFADGTALEIAESTAAENCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJF1</accession>
    <name>A0A3N6LJF1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase family protein subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88051">
        <property type="protein sequence ID" value="RQG88051"/>
        <property type="gene ID" value="EA462_14470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="289" mass="31053" checksum="6DC0B8F350D0C77A" modified="2019-02-13" version="1">MTRMSAQTEYHRPETIDSVCEMLEELSDPTIVAGMQSLGLLMKEGIVSPETLVDINGVEGLDGIEREDDHVRLGAIANHRDVECSEIVTEGVPVLATAASEIADLQIRNAGTIGGATAYADPTGDYPPVLMALDATIVSRTTDDELEREAGEFFTGFYECALGPSELLTEIRVPTIGDGEGTGYEKLAYRENDRAIVNVATYLSLEDDRCGSARIVVGSVSDRPVFAPDAADSLVGTAVTDDDIAEAAEATAEEVPIDPDPTVSVDYRRSMVRNLTEKTLQTAREEGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJG3</accession>
    <name>A0A3N6LJG3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88823">
        <property type="protein sequence ID" value="RQG88823"/>
        <property type="gene ID" value="EA462_10495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="168"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="305" mass="31489" checksum="F7D5EE2A1E5AD37F" modified="2019-02-13" version="1">MVLEISDALLGVLLAIAGAIAFSGQFLFVRLGTEDGGVDDAVLVVLLCNVAMVVPPVAFLYSPPYSSLFTPASFASFAGAGLAGMFVARLLMFKSIEEIGASLTSPVIASNVLFATVFAVFLLGERLTTVHFVGIVLIVVGLAVVSWETAATTNPDQSIRDTGATLVLPFAAAVCIGIEPIFVSTGLSGGTPILPGLAVMSVAGTVGFVSYLAMMGSLRPIEFRSTSTAWYVGAGVSTTVGFLAYFSALEIAPVVIVMPLLQLTPLIVALISMVFLPQRLERVTWPVVASALVVVVGAALVSLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK19</accession>
    <name>A0A3N6LK19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_16290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86698">
        <property type="protein sequence ID" value="RQG86698"/>
        <property type="gene ID" value="EA462_16290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG86698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="279" mass="29084" checksum="7145620ED5507C49" modified="2019-02-13" version="1">MSWLDNRVVLVTGGASGLGRAVVRRFVEEGASVGILDVSADGLADLSDEFGDSVVTSTGDVTRLSDNEDAVERTVDAFGKLDVFVGNAGVFDDNVTIAELPDDDEAIADSFRDLFEINVLGYLLGAKAALPELVETNGRMVFTASGASFEPDGGGSLYVPSKHAIAGIVRQLAFELSPSVSVNAVAPGYVPTNLSGIESLEREEGGVLDESEFDPSVHPAGIVPTPADYTGAYVLLASEENSRPMTGTIVRADLGRNVRGIGNVSGRALEFVTDGVDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK69</accession>
    <name>A0A3N6LK69_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89143">
        <property type="protein sequence ID" value="RQG89143"/>
        <property type="gene ID" value="EA462_12285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="259" mass="28692" checksum="C1911B67DDB521E6" modified="2019-02-13" version="1">MPYADLHVHTTRSDGCLELAAVPDVARRAGVSVVAITDHDRVQPFDKPRIVRDGITIVHGIELRVECDTGLRVDLLGYGIDPTDELVAMTDRIQTNRIERGQEIVDCVEDETGVDLGVTVTGGFGRPHIARAVDDHPELVENYREAFDDLIGADCPCFVPRAVPSFERGRAVLTAAADIVSLAHPLRYRDPERALGLASELDAVERWYPYDRDVDRRLVERTIDRYDLLATGGTDAHGDRLGVAGLSKSQYDRLELTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKC6</accession>
    <name>A0A3N6LKC6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89223">
        <property type="protein sequence ID" value="RQG89223"/>
        <property type="gene ID" value="EA462_12725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="312" mass="33710" checksum="D245F16A14B2ABF7" modified="2019-02-13" version="1">MDLSDRTILLTGGAGLVGSELARELTAENDVLVVDDLSNGVRGCVPSSAEFVEGDISAAETLEGVVTSDIDVVIHCAAADKYVNSDEPRRQFESNVGMTHSLLEQVDDVGITDVVFTSSSTVYGEAPRPTPEDYAPLEPISAYGAAKLAEESILSVYAHTRDLSVWNFRFANVVAPRSGAGVIPDFVEKLERDPDTLTILGNGRQEKSYMHVEDCVDAIRHVTERAPHSAGPMQTYNLGTKTTTSVDRIADIVSEEMTLDPAYEYTGGDRGWAGDVPKMRLSVEKLSALGWQPEYSSDQAVRQVARELATAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKG5</accession>
    <name>A0A3N6LKG5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_14760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86918">
        <property type="protein sequence ID" value="RQG86918"/>
        <property type="gene ID" value="EA462_14760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG86918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="445" mass="49537" checksum="82BF4AA197B8FFC8" modified="2019-02-13" version="1">MSTKTPSEADILRPIQETSTKYYALVGVAGLAFALFLVGWAYQLWEGLAVTGLSDWGTGGGVTWGVYIGAFIWWVGIAHGGIILSAAVRLLGMDRYMPVARLAELLTIAGLSAAGFYILVHMGRPDRMVTSVLGHYHITVNNSPLVWDVTVITAYFVLTATYLGLTLRYDVSRLRDDLPDHFDPIYTALTVGYSEKEDEVVQRMVWWLALAIIIMAPLLLHGGVIPWLFAVLPTYPRWFGGVQGPQFLTIALTSAISGVLLLSYGFRWAYDWDHIITDDVFRGLTLWLGFFSLLFLWLQLQQVTTGTFFPPVDLDAAWTATLTHPIYLVSMTLVAAVLAYIFAQAIRPTLFTKSRAVVCGVAILLATLLEKVLFVVEGFFHPTMEIYYATPGTYFPSFIEIASITGTIGMVTLFFLLVAKVVPVVELHAIEHLRDDHERDDVRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKL2</accession>
    <name>A0A3N6LKL2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86988">
        <property type="protein sequence ID" value="RQG86988"/>
        <property type="gene ID" value="EA462_15170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="12"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="441" mass="47110" checksum="429A7B5B8BFA119D" modified="2019-02-13" version="1">MRSIGGLSRDEYLFGVLIASVHAGQHVLFRLFPPLIPILVVDLDSPLWQLGLLVSVSMFAGGIFQAPMGILSDRLDRLYLLAPAFVAMSFGYLIFVLAPGIGPMIPEISVGGHVFDGAYQIMALGMFVVGIGYSAIHPVGYPLISANVATENKGKVLGMWGSASKVGDAVAPFLIGAFIVVLPWEWILVGVSLFGFAYAFGLVFAFKSGPYETRPPETDDDRSSSSSQTAETDRRQFWFPMAAVVLSFFFILFAGNGLITYAPVFVSDVYGFSVSMAGYTFEPASVANFYFGVLLMSGAISQLVLGGLADAYDYRAVLISLLGVSAVALVVLATIDLTPVLLLVVFVVIGATQFGLNPARDALISEITPAEYEGRTFGYIWTLALVGSSIYPVVVGYVADTSGLRASFATLAIGAVGGLVCIALLYSPRVYQERTPAKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKR2</accession>
    <name>A0A3N6LKR2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87068">
        <property type="protein sequence ID" value="RQG87068"/>
        <property type="gene ID" value="EA462_15665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="127" mass="14455" checksum="79CF3770C9ECFAF3" modified="2019-02-13" version="1">MHRRAFLSLAIVLPGCLDFVEENGEDITEPGDVEIVWDDLVRDDPGTEDERVYVWAVVRNVGERTLSYIEIRATFFDEEGEQLESVIENVDEDVSSGEQWAFEVEFPHFGERAAEVESYELEPATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM91</accession>
    <name>A0A3N6LM91_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0391 membrane protein EA462_10905</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_10905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0391 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88897">
        <property type="protein sequence ID" value="RQG88897"/>
        <property type="gene ID" value="EA462_10905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01361">
        <property type="entry name" value="UPF0391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009760">
        <property type="entry name" value="DUF1328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07043">
        <property type="entry name" value="DUF1328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="62" mass="6618" checksum="FBA9232981D42CEE" modified="2019-02-13" version="1">MFEFTTPMQLGGGGFLYWAIVFFVLAIIAAAVGARGVAGISMEIARIFVLIFIILAIVALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMA6</accession>
    <name>A0A3N6LMA6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90128">
        <property type="protein sequence ID" value="RQG90128"/>
        <property type="gene ID" value="EA462_09050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043903">
        <property type="entry name" value="DUF5785"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19098">
        <property type="entry name" value="DUF5785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="107" mass="12259" checksum="F60DDB2D0923D72C" modified="2019-02-13" version="1">MSEWPHDPDGEEGSEGGRKYDMAIIAKKVDEEADFPLERDEFVAEYGDDPIRINYETVVPLSEIFEYVEETEFETITDMHKAVGAAMRAGDFWDYHPQGADPEKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMB1</accession>
    <name>A0A3N6LMB1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Rhomboid family intramembrane serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">EA462_09510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90213">
        <property type="protein sequence ID" value="RQG90213"/>
        <property type="gene ID" value="EA462_09510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="SSF118310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG90213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="317" mass="33466" checksum="0F63946B7864BCBC" modified="2019-02-13" version="1">MAKCDACGKDESMPYNCRHCGGTYCAEHRLPENHGCSGLKDWNDPNGVFDSGFDDSVQNGGRSSASSRVLEKLPIDTGPGGPLAYFRGNMTYTFLALMWLTFLLQWIAIAVGGAFGFPNLHRALFVLAPQNPEYVWTWVTSVFAHSPINIFHIVFNSIVIFFFGPLVERYVGSKKFAILFVVSGALAGLAQIGIQITQGLGAIPAAGGVLGASGAALAIMGVITVLNPSLKVYLYFVLPVPIWLLTAGTAVISVFFIGTGGGGNVAHMAHLVGLVIGLGYGEYVKRTQNVRAPSQFQLGGGPGGPGGPGGPGGRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMB6</accession>
    <name>A0A3N6LMB6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-dehydroquinate synthase</fullName>
            <shortName evidence="3">DHQ synthase</shortName>
            <ecNumber evidence="3">1.4.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate synthase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroB'</name>
        <name evidence="4" type="ORF">EA462_11065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3-dehydroquinate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:25956"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58859"/>
            <dbReference type="EC" id="1.4.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal-type DHQ synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.24" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88927">
        <property type="protein sequence ID" value="RQG88927"/>
        <property type="gene ID" value="EA462_11065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102042">
        <property type="term" value="F:dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01244">
        <property type="entry name" value="Arch_DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002812">
        <property type="entry name" value="DHQ_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33563">
        <property type="entry name" value="PTHR33563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01959">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006655">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="394" mass="42926" checksum="F5A51CE76590D953" modified="2019-02-13" version="1">MTRSVWIKADDTVGDWDDRRARITTALEAGVDWVLVDEDDVSRVRELGEINVAAFRTDGDVTLVDDVEADDSDAAADAIVVGKDGEGDATIDLPEDFSGSADLSTLRRDGETDLERGAYVRILGTEYEAFAETAAEEADHTIVIGDDWTIIPLENLIARIGEETDLVAGVTSAEEAKTAFETLEIGADSVLLDSDDPDEIRRTVEVRDQAERESLDLEYAEVLDVEQIGSADRVCVDTGSLLEHDEGMLVGSMSRGLVFVHAETADSPYVASRPFRVNAGAVHAYVRTPDGGTKYLSELRSGDEVQIVDTAGHTREAIVGRVKIEKRPMFRIALETADGDRIETLLQNAETIKVSTAEGRAAVTDLEAGDELLLYYEDTARHFGEAVEESIIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMB9</accession>
    <name>A0A3N6LMB9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1508 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_09160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90148">
        <property type="protein sequence ID" value="RQG90148"/>
        <property type="gene ID" value="EA462_09160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010879">
        <property type="entry name" value="DUF1508"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036913">
        <property type="entry name" value="YegP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07411">
        <property type="entry name" value="DUF1508"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160113">
        <property type="entry name" value="SSF160113"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1508" evidence="3">
        <location>
            <begin position="519"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1508" evidence="3">
        <location>
            <begin position="575"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1508" evidence="3">
        <location>
            <begin position="749"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="971" mass="108180" checksum="F957F8F9F1A9CCEB" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMJ9</accession>
    <name>A0A3N6LMJ9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <shortName evidence="7">DHNA-octaprenyltransferase</shortName>
            <ecNumber evidence="7">2.5.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">menA</name>
        <name evidence="8" type="ORF">EA462_07660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26478"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="EC" id="2.5.1.74"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cell membrane</location>
            <topology evidence="2 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MenA family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="7"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90353">
        <property type="protein sequence ID" value="RQG90353"/>
        <property type="gene ID" value="EA462_07660"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="313" mass="32928" checksum="26826652B450C7B2" modified="2019-02-13" version="1">MSTADEISRTKAWMMAARPQTLPAAAAPVIVGTGLAVHDGVFAPLPALIAFVGATLIQIGTNFANDYYDAVKGADTDDRKGFTRVTQAGIIPPDQVKLATIVTFALAILSGTYLVYEGGLPILVIGLVSVLCGWAYTGGPYPLGYHGLGDLFVFVFFGLVAVVGTYYVQAATVLAEPLAATVPPGTITREAIVASLPIAGLATAIIVVNNIRDKETDAETGKRTLAVRLGYRWTRLEYVAMVGLAYLTPVWLWLIEGFSPAVLLPVASLPYAALIARTVCTRTDGEALNPALEETGKLLAIFAVLFGSGLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMP1</accession>
    <name>A0A3N6LMP1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90338">
        <property type="protein sequence ID" value="RQG90338"/>
        <property type="gene ID" value="EA462_10210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="77" mass="8135" checksum="B1C607E6AEDE53E3" modified="2019-02-13" version="1">MDAREYWNLIVSVVAIGIGISVVDTSIVAAICLVTYGSLAGLQLFNEEFEAFVSNHSAAVSAFQTLLLIGALAALYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNZ5</accession>
    <name>A0A3N6LNZ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87937">
        <property type="protein sequence ID" value="RQG87937"/>
        <property type="gene ID" value="EA462_13830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="1">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="6233" checksum="9C5AF2731D61A2C0" modified="2019-02-13" version="1">MDRRDRNVFRGRSGHIIPWISPTLLAAQSIAPALAAGTTVVTNSTGGTVRRLQGEQSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP01</accession>
    <name>A0A3N6LP01_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-aspartate oxidase</fullName>
            <ecNumber evidence="4">1.4.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Quinolinate synthase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_03815</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91133">
        <property type="protein sequence ID" value="RQG91133"/>
        <property type="gene ID" value="EA462_03815"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="9"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG91133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="514" mass="54938" checksum="310963062E66827B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP59</accession>
    <name>A0A3N6LP59_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_14395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88037">
        <property type="protein sequence ID" value="RQG88037"/>
        <property type="gene ID" value="EA462_14395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="98"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG88037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="303" mass="34166" checksum="2AB755D172DB6490" modified="2019-02-13" version="1">MTTKDTDSVHETLADRLPLWGSLSYPQRNRIMRWLGHGVLGVWVGIMLFPILWMLNSTIRLPATLQARDPPLISFELAHYGLDNLHYVLFFSSFPRYMFNSLLVTSGVIVLTVVASTFGGYGLARIDMPFKKTFARGVLFGYMFPAILLAIPMFIFWREIGILNSYIGLTLAHTALALPFSLWLMWKFFQTVPYSLEESAQVGGASRFRSMIEIAIPIAKPGIIAVAIFAFAISWNQYTIPKVIMSDQSMQVLTVGVEDFMIQDDTLYGPLMTASFITIIPAFIFVFTLQKYLIQGFRVEGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP77</accession>
    <name>A0A3N6LP77_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0391 membrane protein EA462_07805</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_07805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0391 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89907">
        <property type="protein sequence ID" value="RQG89907"/>
        <property type="gene ID" value="EA462_07805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01361">
        <property type="entry name" value="UPF0391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009760">
        <property type="entry name" value="DUF1328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07043">
        <property type="entry name" value="DUF1328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036466">
        <property type="entry name" value="UCP036466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="48" mass="4956" checksum="82143ACA3E58CDC0" modified="2019-02-13" version="1">MLELALLFVVIAIIAGALGATGVAGLTMSIAKWLVLLFLVLAVISFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPA4</accession>
    <name>A0A3N6LPA4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91258">
        <property type="protein sequence ID" value="RQG91258"/>
        <property type="gene ID" value="EA462_04510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="598" mass="63142" checksum="63974D50946BCB68" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPE2</accession>
    <name>A0A3N6LPE2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA epimerase</fullName>
            <ecNumber evidence="3">5.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mce</name>
        <name evidence="3" type="ORF">EA462_04870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.1" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91318">
        <property type="protein sequence ID" value="RQG91318"/>
        <property type="gene ID" value="EA462_04870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="127" mass="14202" checksum="D243BB1FFD424F36" modified="2019-02-13" version="1">MHFDHAGIATEDARELAELYETLFGLEAIHEEEFDGMRIVFLECDGGYFELLEPLEEGPIAKYIETNGPGIHHVAFATEDIAGALESVREHDVRVLDERPRPGAWGHTVAFLHPSDTGGVLFEFVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPJ2</accession>
    <name>A0A3N6LPJ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_08690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90067">
        <property type="protein sequence ID" value="RQG90067"/>
        <property type="gene ID" value="EA462_08690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="38"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="507" mass="54454" checksum="2D418F42F39D3647" modified="2019-02-13" version="1">MSSDKSVRETKSDVLERHERAEAEYLEWTPRLFIGGEWVEGTSGSTFETSNPTTGRTIATVPEAGEADVDEAVDAARRAYEETWSEYSATERRNILNEIADRIEDATERLATIETLNNGMPIGDAHWDMERTAEQYRYFAGMTQANHGTTIPSEGTKTVMTVREPHGVVGAIIPWNYPIAQASWKLAPALAAGNTVVLKPAEQTPISILAFLEEIEDLLPDGVVNVVTGRGEPTGAALTSSPDIDKLAFTGSTAVGKTVMKSAAENVTDISLELGGNSPIVVFPDADPQRAAEIAAGAIFTSTGENCCAGSRLFVHEAIETDVLEALSEVATEYRPGDPLLESTAIGPKVSAAQRDRTLEFIAAATGDDANVVTGGSVPDDESLGDGQFVLPTVINEIDHDHRAVQEEIFGPVLRAFSWSDYDEMIELANDVDHGLAAGVIASDITDAQTAAKDIEAGTVWVNQYNDFPQGMPFGGYKQSGIGRERALETLTAYTQTKTINISDEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPK0</accession>
    <name>A0A3N6LPK0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Redox-regulated ATPase YchF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ychF</name>
        <name evidence="3" type="ORF">EA462_08745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90077">
        <property type="protein sequence ID" value="RQG90077"/>
        <property type="gene ID" value="EA462_08745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="MMR_HSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="MMR_HSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="3"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="397" mass="43495" checksum="52693B2A7B099786" modified="2019-02-13" version="1">MSHRIGLVGKPSVGKSSFFNAATMNDVPEGAYPFTTIDPSVGEAYVRVECAAPEFDEQCTPNVGYCDDGTRFVPTKLVDVAGLIPGAHEGNGLGNQFLSDLNETDVLIHVVDFSGETDLEGEPTEDHDPRDDIAFLEEELDQWYLGVLEKGIERYESGYTTEDDAIEEELATQMSAFKTNEDEIKRLIRRTDVGFDPEEWDPEAKLALAREIRTETKPMVIAANKMDTTEAQENYEEITSDSDYDHLTIVPCSAHAEKALKSADKAGVVDYRPGDSDFEITGDVSGEQTQGLEQIREFLATYGATGVQAALETALFDVLGVKPVFPGGANGLGNERGEVLPDCYLVPPNATAEDFAYSLHSDIGDGFLHAIDCRSNRQLGKDYEVEPRDVIEVITTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPM3</accession>
    <name>A0A3N6LPM3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA-ribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_10500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; archaeosine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeosine synthase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88824">
        <property type="protein sequence ID" value="RQG88824"/>
        <property type="gene ID" value="EA462_10500"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00393"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040777">
        <property type="entry name" value="DUF5591"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029402">
        <property type="entry name" value="TGT_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038250">
        <property type="entry name" value="TGT_C2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17884">
        <property type="entry name" value="DUF5591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14810">
        <property type="entry name" value="TGT_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="517"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG88824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="585" mass="65182" checksum="C10C1DEEAA65408B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ45</accession>
    <name>A0A3N6LQ45_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90357">
        <property type="protein sequence ID" value="RQG90357"/>
        <property type="gene ID" value="EA462_07905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="105" mass="11211" checksum="94CE12B30E1A1144" modified="2019-02-13" version="1">MTDADGERIVETDGIVATYDETETERLLEFEGSEPTASGRATAGGTAAIAQNREGYAMLKVRPTADGDELERYYGFDMALDHAAELLGVSPQDLPIPPAADDMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ48</accession>
    <name>A0A3N6LQ48_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA carboxylase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_03600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91683">
        <property type="protein sequence ID" value="RQG91683"/>
        <property type="gene ID" value="EA462_03600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="261"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="514" mass="56755" checksum="318A6C02644312BC" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQA5</accession>
    <name>A0A3N6LQA5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89124">
        <property type="protein sequence ID" value="RQG89124"/>
        <property type="gene ID" value="EA462_12185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="62" mass="6662" checksum="FA541E04221929B8" modified="2019-02-13" version="1">MDLASFLLATAVAHVGFAIFVAVHAALSDRDAENWPYITLVLGLAGVAAYFFYDETDRSGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQJ1</accession>
    <name>A0A3N6LQJ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3209 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89244">
        <property type="protein sequence ID" value="RQG89244"/>
        <property type="gene ID" value="EA462_12840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021577">
        <property type="entry name" value="DUF3209"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11483">
        <property type="entry name" value="DUF3209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="123" mass="13642" checksum="566B0E2310657993" modified="2019-02-13" version="1">MSCHEIEALRLGLMTVLGVGDESTREHAEKELEGHLEGPIEGLANAETLSEIQRHLDAALVDLEEEVATMNDDDPEFDYTRGRLLEVRNGERAIQRLVTHGESIVDGLGTAHDTLHETFPVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQM0</accession>
    <name>A0A3N6LQM0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BCCT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_12565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89294">
        <property type="protein sequence ID" value="RQG89294"/>
        <property type="gene ID" value="EA462_12565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="538" mass="57437" checksum="C8423739485B4B7E" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRM7</accession>
    <name>A0A3N6LRM7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89804">
        <property type="protein sequence ID" value="RQG89804"/>
        <property type="gene ID" value="EA462_07230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="253" mass="27517" checksum="40951AF2B02F8820" modified="2019-02-13" version="1">MEGFETLRELTRSPVRLDVLRHLLDYGPANATELTDHVDASRRTVSRALDVLENEGLATSNSRTYSATTYAELTASDVFELIEQIESRRDRAAFLNAFPRDAVDVDFETVSGTATRRLSVQPHGPVSNVIDTLTDATSIRVLAPIASPLYVRPFAERVRDGADIEAVVDATAYEEFCGKLHAGIRLAATLADISLAVHDDVGFGLIICDEQVVFGAYEDGILQATFSTAEPAVVNAAKETYQKNRGTATPVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRQ2</accession>
    <name>A0A3N6LRQ2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="1">6.3.4.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Archaeosine biosynthesis protein QueC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">queC</name>
        <name evidence="2" type="ORF">EA462_07395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89834">
        <property type="protein sequence ID" value="RQG89834"/>
        <property type="gene ID" value="EA462_07395"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01633">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00364">
        <property type="entry name" value="TIGR00364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="257" mass="28268" checksum="229F50370008B9E3" modified="2019-02-13" version="1">MTIDENTDSDTGTDDPVEPALEFAAEPTDGRAVVLLSGGMDSATAAYAARDRGYELCCLHTTYGQRTEDREHDCARKLASELTASDFLRIETDHLAEIGASSLTDDGMALEDADTERDEIPSSYVPFRNANLLSMAVSYAEATDCETVVIGAHSEDFSGYPDCRPQFFEAFERLVAVGTKPGTEITIDAPFVDWSKTEIAEYGIDLGVPYEHTWSCYRENEPACGTCDACAYRLQAFQRIGVRDPIAYERRPSYTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRR1</accession>
    <name>A0A3N6LRR1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein gvpG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89854">
        <property type="protein sequence ID" value="RQG89854"/>
        <property type="gene ID" value="EA462_07515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="84" mass="9949" checksum="E27D7409E1C7BC06" modified="2019-02-13" version="1">MFILDDLLFRPFVGIVDALHTIALDELYDVEGLEDDLKENQLLYELGERSEDEYRRRKDELETELEVARDVHERLASGRVEVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRX4</accession>
    <name>A0A3N6LRX4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Type 2 DNA topoisomerase 6 subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Type II DNA topoisomerase VI subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">top6A</name>
        <name evidence="10" type="ORF">EA462_08070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89954">
        <property type="protein sequence ID" value="RQG89954"/>
        <property type="gene ID" value="EA462_08070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00132">
        <property type="entry name" value="Top6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004085">
        <property type="entry name" value="TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="PTHR10848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01552">
        <property type="entry name" value="TPISMRASE6A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="SSF56726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TP6A_N" evidence="9">
        <location>
            <begin position="69"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG89954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="363" mass="41462" checksum="E3C1A4719AA296B9" modified="2019-02-13" version="1">MSTDSDQQAREQLIDLAAQFYDQFELGEIPHMSVPTRTKNNIEYDEEMGVWVYGDRESTRSANSVRGARKLLKAVYTIEFLANQLEQDRSSTLRELYYLSESWDNKEAQFSDQDESNGLIEDLEIVSGVTREDFHMRPEESGATIMGPLHLREQTRRGEREIHCQEDVGEGGYQIPNNPDTIEFLGSEADFILAVETGGMRDRLVENGFDDEYNALLVHLKGQPARATRRITKRLHDELDLPVLVFADGDPWSYRIYGSVAYGSIKSAHLSEYLATPEAQYIGIQPADIVEYDLPTDPLSDSDVNALESELEDPRFQTEYWEEQIELQLEIEKKSEQQSLASHGLDFVTDTYLPERLDEMGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS33</accession>
    <name>A0A3N6LS33_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91307">
        <property type="protein sequence ID" value="RQG91307"/>
        <property type="gene ID" value="EA462_04795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="70" mass="7965" checksum="F6CADE8870AB0C96" modified="2019-02-13" version="1">MSHSVPDVIETILESVEDDVADPDLRYKIRTARQLLVLVDEQHTVAKGALEESGLEEDTRERLEQLGYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSA1</accession>
    <name>A0A3N6LSA1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92773">
        <property type="protein sequence ID" value="RQG92773"/>
        <property type="gene ID" value="EA462_00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="59" mass="5805" checksum="7390590DB5F8F0AA" modified="2019-02-13" version="1">MLDKLGPLGIAGIVLLLAGIGLIAYADIVIAAGLALVIAGLGIVVKALVTSVLQGFGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSG6</accession>
    <name>A0A3N6LSG6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92873">
        <property type="protein sequence ID" value="RQG92873"/>
        <property type="gene ID" value="EA462_01215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="153" mass="16248" checksum="DDB8DA304DD857B5" modified="2019-02-13" version="1">MDDREPFSVDTVLAPVDGSEESATAVEYAISVAERYDASVHALYVLGRGVVRGMDAGTVEEDMIAENTQGFFENVSTVADAAGVTLSTSVDDGFSQSRKTRHPGNVVLDTADEIDADFVVLPREPVTDTAAAEVLEKAAEYVLSYASQPVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSM0</accession>
    <name>A0A3N6LSM0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine 2-epimerase (Non-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91517">
        <property type="protein sequence ID" value="RQG91517"/>
        <property type="gene ID" value="EA462_06025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="360" mass="39883" checksum="CDBD41FBC4C54F6B" modified="2019-02-13" version="1">MSSTLSFVLGTRPEIIKLSPVIRACQRREIPFSIVHTGQHYSEKLDSVFFEQLGLPAPEYNLTIGSSSHGEQTGRMVVEIESVLEKERPDVVLVQGDTNSVLAGTIAATKLDPILVGHVEAGLRSFDRDMPEEVNRRLADHAADYLFPPTETARDQLLEEGLPAEWMTITGNTIVDAVTENTSIAHERSDVLSEFGVRERFALLTAHRAENVDDRERFASLIDSVAAAVRKHDLSVVYPIHPRAEKRISTLDIDVPEEITLVEPQDFLDFLVLEDEAEIVFTDSGGVQEESCILRTPCVTLRDNTERPETIAVGANRIVGVERASVVNGVREMLAVEPDWKNPFGDGTAAEQILDALEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSU5</accession>
    <name>A0A3N6LSU5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_02290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93058">
        <property type="protein sequence ID" value="RQG93058"/>
        <property type="gene ID" value="EA462_02290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="293" mass="31050" checksum="62B22B2FF9A77A30" modified="2019-02-13" version="1">MSPSTISDRLRASPADGILGVAIEPRTYKNLCYLLLAIPLGFAYGFILLFGFLFGAILSLFGIGLVILLAVLVSARVLAGFERVLANALLDLELERPEDTRTGSSGLWGTFKRYLEAASTWRGVGFLVLKSWLAVVAFVLLIVFATLVSLVSSPLRYPHEVEFVTVNDEPIAWAIGTLPEAALAAFLGLVGLVLFAHVSNAVAYVAGRMALAMLDGSASTDEAEPPTEPESSDGSNAATEPESLEGRDEPENADPLENPNAPENPDSSEGSNALDDSSAPEDSDPSEDPSSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSW6</accession>
    <name>A0A3N6LSW6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HSDR_N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93088">
        <property type="protein sequence ID" value="RQG93088"/>
        <property type="gene ID" value="EA462_02465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029464">
        <property type="entry name" value="HSDR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13588">
        <property type="entry name" value="HSDR_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSDR_N_2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="397" mass="44534" checksum="E5E6A1C52BE471C7" modified="2019-02-13" version="1">MDSDEVAEYVERSQQLLEASPQMNEQNTKVRLVQPLLELLGWDLYSTEVELEYTVPMASGSTHVDYALLVGDSPVVFVEAKAASSGLSSQHVTQLKSYMRQELDVDWGILTNGKEFEVLTKDQYSNDGEEVSVVQFDLDDLAENPDVLELLSKEAIRSGKADEIAGQVAQTNEAIRYLNQNEDDVTETVSSAVESELGEVPLDLDEQSRDFVQNLASALQEQRQFVSEDPPAGTDEPPPSPPREEPDEDGELQPRQNKVVGTITRDEIDGDEDATVAVYASKESGLTFLKENAAWAFVRVGRDMDYIAMYITGGESVVKYFAEVDEIVDPEEADLERDPLDYLDRDYVGEGKKVIKFQNHTFYELEDPIPFESKYPQSRRDTTLGKLREAETTDDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LTC1</accession>
    <name>A0A3N6LTC1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol reductase thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_02350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93308">
        <property type="protein sequence ID" value="RQG93308"/>
        <property type="gene ID" value="EA462_02350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="89" mass="10197" checksum="1BE022355C204F4A" modified="2019-02-13" version="1">MTVTLKDFYADWCGPCKTQDPILEELEDDWDGRFEVEKINVDEQQDVANEYQVRSLPTLIIENDDGVVERFVGVTQRTDIEDALESADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUT0</accession>
    <name>A0A3N6LUT0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl22</name>
        <name evidence="7" type="ORF">EA462_05050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="4 6">This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91344">
        <property type="protein sequence ID" value="RQG91344"/>
        <property type="gene ID" value="EA462_05050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_A">
        <property type="entry name" value="Ribosomal_L22_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_L22/L17_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="PTHR11593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="165" mass="18281" checksum="95AD5B2E91D399F1" modified="2019-02-13" version="1">MGINYSVDADPETTARAMLRERHMSHKHSKEIARELKGRTIDDARAYLQDVIDGERSVPFRSHNSGVGHRSDIDGWDAGRYPEKVSNEFLELLENVEANADHQGFDGASMEIVHVAAHKVGESVGRKPRAMGRASAWNTPEVDVEIVVGEEPRSSDEDGSTEDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LV22</accession>
    <name>A0A3N6LV22_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91484">
        <property type="protein sequence ID" value="RQG91484"/>
        <property type="gene ID" value="EA462_05845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="109" mass="11088" checksum="E05843B08335C3DE" modified="2019-02-13" version="1">MALDRIDGIAFVGFVLVGVAATVLDGALAAAALAGVLLSVASWRLYGGRPWEALGWLSWVGAAVTLVIDPGGLTFLVAFGGFGLVGICLLVGDRLGFLPDVWTVGTATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVM1</accession>
    <name>A0A3N6LVM1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske (2Fe-2S) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_00780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92797">
        <property type="protein sequence ID" value="RQG92797"/>
        <property type="gene ID" value="EA462_00780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="619" mass="68021" checksum="405645861F5F70CD" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXA9</accession>
    <name>A0A3N6LXA9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86661">
        <property type="protein sequence ID" value="RQG86661"/>
        <property type="gene ID" value="EA462_16085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="146" mass="16410" checksum="3438A731FA9111F1" modified="2019-02-13" version="1">MSNGKGTRYNVGGGDDGLDTDEGDDDRTPARTERDERPESSDTNERRQSDEPEDSSGSQTAARGADELPHRIRCDSPKDERDEKTFVLARSDRKRLRELEDVAEDEFEESVYKMDIYLAGLRAGLHSTDEAFLEEMRGIGYGFLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY04</accession>
    <name>A0A3N6LY04_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin transporter BioY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BioY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86961">
        <property type="protein sequence ID" value="RQG86961"/>
        <property type="gene ID" value="EA462_14990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="195" mass="20018" checksum="A287917748714E30" modified="2019-02-13" version="1">MATQRNSVDLVPDDVVRSFARAALLAALLGAAAPVTIPIPLSPAPITLQILFVFLAGLILGPLWGTVSILLYLAAGAIGLPIFAGMAGGPGVLVGQTAGYLWAYPVAAALIGLLVHRGTSLRDPADESVVVLVGALVAATILVYGMGTAYMAWLLDLEAWEAITLGALPFVPGELLKMAAAIAIVKSGRIEPIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY47</accession>
    <name>A0A3N6LY47_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_00590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92764">
        <property type="protein sequence ID" value="RQG92764"/>
        <property type="gene ID" value="EA462_00590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00941">
        <property type="entry name" value="CDATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG92764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="871" mass="92440" checksum="A8A1EDC66EB34FC6" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYZ6</accession>
    <name>A0A3N6LYZ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rieske (2Fe-2S) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_13810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87933">
        <property type="protein sequence ID" value="RQG87933"/>
        <property type="gene ID" value="EA462_13810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="121" mass="13266" checksum="0F5DFB4F6155CC32" modified="2019-02-13" version="1">MSERVRAGTVGDLGPGERTVVTVDDEPVGVLNVEGDYYAVQNTCEHMGGPVCSGRVQGKLVAEFTEPGQRPEEDFSDDKTIACPWHGWEYELETGDHIGDDRISLETYDVTVEDGVVYVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ75</accession>
    <name>A0A3N6LZ75_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93204">
        <property type="protein sequence ID" value="RQG93204"/>
        <property type="gene ID" value="EA462_03135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="81" mass="9079" checksum="C3C175429C0450C4" modified="2019-02-13" version="1">MKVEFDEDTCIGMYQCVAEWDAFSEDKAKGKAILEESEEVEDGVFVREVPEDAELDAKFAARTCPVDAIVIYDDDGEQLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ97</accession>
    <name>A0A3N6LZ97_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88063">
        <property type="protein sequence ID" value="RQG88063"/>
        <property type="gene ID" value="EA462_14535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="402" mass="44708" checksum="CC6F2A0D201FDA25" modified="2019-02-13" version="1">MCANDVVGNTPSETRRQPVSRRTMLAGGATVVGTSIAGCLGGDGNGNGNGGDDSGEQTQPDSEEPEKPDQITVRAWGGIWQDSLESNVGEVFTDETGIDVVYDNTDGPVMRGDIRTAIQQDREPPITVVWDLNTITHTSYRQELAAPLDPEVVTNTDQMSDSARPDVDGDLPYVNLYSYTYALCYNEDVLEDLTGDREPVDSWDELWDSQYEDMLGAYNDPPGDGLIPVLAELSDTEPGPADEMEPAWDLARELEPNIGYLGTDQSLGQVLQEEQIAYAMAYLPNNIVAPKDDGVPVDWTIPEEGALVRMDSMYTPRNLDESQQYWGQRFINTALEEDVQQNWMEELQVPMLHQNIDPLEWMDDDPAFPTSQEEFDQLLTTDLDVYAEHSSGWFEEFSQITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZC1</accession>
    <name>A0A3N6LZC1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88093">
        <property type="protein sequence ID" value="RQG88093"/>
        <property type="gene ID" value="EA462_13180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="133" mass="14551" checksum="810CA4454A467725" modified="2019-02-13" version="1">MSNVLLPIDDDERHAKDQIQTVLNLPLETDELTVTVLHVFTDNPNSASITQLRSTHLIQEALEDEGIAVELDERSNDPADEILSYAEDNAVDVICLAGRKRSKTGKLLFGSVTQDVILNTNLPVLIAGTDSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M017</accession>
    <name>A0A3N6M017_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_13395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87854">
        <property type="protein sequence ID" value="RQG87854"/>
        <property type="gene ID" value="EA462_13395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="28585" checksum="B8BCAA83FFCC888E" modified="2019-02-13" version="1">MGVNFDKDDFMQFTKSIYSLVIVLILWEVLAQMGLVYYYHLPPLSDVLIEFLELMMTGELIYHSYLTLRRALIGLVIGAIFGITIGILISRNSVVEWFFDPIIKIGYPIPIIALIPVFMLWFGIGDTSKIIMVAIGTFWPIAVNARNSAKQIDKNYIWSARMMGTTDRQLLWRVVLPAASPGIVTGLQIALPLSLIITFVFEMVAGGGGLGALEIDGVRTFNPTQVYAIIIAIMIIGMALDRLLRIGRKHYLQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M083</accession>
    <name>A0A3N6M083_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_11540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89010">
        <property type="protein sequence ID" value="RQG89010"/>
        <property type="gene ID" value="EA462_11540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="81"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="135"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="350" mass="39071" checksum="6409551D5F03E0E1" modified="2019-02-13" version="1">MTETECVELPSVLKELDTGITIHDPESGAVLNVNSRLEQLYGYSTAELREMTVEDYTAPSTTFTQEKAVHRIRAAANGSPQTFDWKIERANGEYRWVTVQLTRTEIEDVPYVLAEINDVTEYRAREHLLRLLNRVIRHNLRNDMNVLLGYADRVKGAIENEQVEKEIDTILDIATEVGSLSDSLDQIENVVQPDATHREPTNLRNLAQMHAVQAKSEYPSADITVNLNSGVWVSADRSLEHAIENAIENAVEHNDRDPPKVEITTETDPRNGLGIISIADNGPSIPDVEIDVLRDESIVDSTYHGSGVGLWVIKWCVDSLGGELAFEENTPRGNTVRIGLPKIRHESADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M0H5</accession>
    <name>A0A3N6M0H5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase</fullName>
            <ecNumber evidence="1">2.8.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89130">
        <property type="protein sequence ID" value="RQG89130"/>
        <property type="gene ID" value="EA462_12215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="282" mass="30914" checksum="96AC7B70C38FF390" modified="2019-02-13" version="1">MHVLGIVGHDARDETLETVVDQAVERLSGAGRVGVVRYDATIADGMTASETITVGGDVTYELGADGDWTATGTGLSVDDALDRLALDCEYAVVVGVRPLQYPSVVVGSGRTGEDSLDVESDHVIATVETAAELADIDLATELERVDPYETLESLVARVKRSPLADRSGAIATFTGRVRAKDAEDDDRTQYLEFEKYEGVADERMNALEVDLEKRDGVLSVELYHRTGVIEDGEDIVFVVVLAGHREEAFRTVEDGINRLKDEVPLFKKEVTIEDEFWVHEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M1T7</accession>
    <name>A0A3N6M1T7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89041">
        <property type="protein sequence ID" value="RQG89041"/>
        <property type="gene ID" value="EA462_11720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="533" mass="53821" checksum="41392DEA59D0E4B0" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M247</accession>
    <name>A0A3N6M247_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89870">
        <property type="protein sequence ID" value="RQG89870"/>
        <property type="gene ID" value="EA462_07600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="26"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="282" mass="30545" checksum="8078CD8138318363" modified="2019-02-13" version="1">MVPGVDDADAISPEHCPTTNGIPMLGLGTYRNTDPDQCTESVRTALEVGYRHVDTAQLYDNERAVGAGIDRADVDREDVTLATKVWYTDLSYDDVLETTRASLARLGVDSVDLLYVHWPADTYDADETMAAFSELADDGLIDAVGVSNFTPELLGEAIDACDVPIVANQVELHPLLQQPELREVCASHDVAVVAYAPIARGAVVDHPVLREIAADHDGTEVQVSLAWLRQNGIVAIPKATGTDHIRQNWASLGLELEPAELERIDAIDAGRRAVDPDLAAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M2T0</accession>
    <name>A0A3N6M2T0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Flap endonuclease 1</fullName>
            <shortName evidence="11">FEN-1</shortName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fen</name>
        <name evidence="14" type="ORF">EA462_09060</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90130">
        <property type="protein sequence ID" value="RQG90130"/>
        <property type="gene ID" value="EA462_09060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019973">
        <property type="entry name" value="Flap_structure-sp_endonuc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03674">
        <property type="entry name" value="fen_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 11 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPGN" evidence="13">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="XPGI" evidence="12">
        <location>
            <begin position="141"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with PCNA" evidence="11">
        <location>
            <begin position="317"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RQG90130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="325" mass="36275" checksum="D5411DFB69D65C3E" modified="2019-02-13" version="1">MGNAALRDIAVIEEVPFEEIEGVVAVDAHNWLYRYLTTTVKWTNSEKYTTGDGTEVANLIGIVQGLPKFFENDVTPVMVFDGGPSELKADEIESRREQRQTYEEQLEVAREEGDAVAIAQLESRTQRLTPTIQETSRELLRLLDVPIVEAPAEGEAQAAHMARRGDAEYVGSEDYDALLFGAPLTLRQLTSKGNPESMDLEATLDHHEFTLEQLIDAAILIGTDFNDGVSGIGPKTAIAEITEHGDLWSVLEARGDSIEYGDRVRQLFRQPNVTDDYDVEPSLDPDIEAAREYVTDEWNVDAGEVERGFERIEESLTQTGLDRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M391</accession>
    <name>A0A3N6M391_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_10170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90330">
        <property type="protein sequence ID" value="RQG90330"/>
        <property type="gene ID" value="EA462_10170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="27841" checksum="EE6354C02DE3F2DF" modified="2019-02-13" version="1">MTDHRSDRVSELLDAADAGGASLVGSDDDRDESVEEATSTIRDAAREADELVATTEPNELLEAVGIAVSTDDDADDTIPAAIARGDADRLEDLNRLLSLARLGGRSDEDSQEQAVDLLTSARKSESVDDGVTAGEADAGTDLEDRLRSTMSTTIDSAEDELTQLRERLESASAAAVDGRADDENRVEEDESESDTEDETDSEDEKTATEGETDDDGFGFGSAGGRSSSSGRSGRHSTVAPSPSRRADMKAVRRFSTMPETTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3N3</accession>
    <name>A0A3N6M3N3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89811">
        <property type="protein sequence ID" value="RQG89811"/>
        <property type="gene ID" value="EA462_07265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="342" mass="37471" checksum="9321A056BD99353F" modified="2019-02-13" version="1">MAKGLDVGTMNILSAQQDGNDTVFVQQRNSFVEIEYSDMAEQMLSRSEVLHIRKDDKVYVVGDDALNFANIFNKETRRPMKHGILSNDEKSAIPMMKLIIEQVVGEPAYPDEKLYFSSPADPIDSDLSTLYHQKTIESFLDDMGYDSEPINEGMSVIYSELADNNFTGLGISFGAGMTNVCLSYYAVPVMKFSVARGGDWVDEQAARATGTPVDKVTSIKEDDFELDFTTDVGGVEGALSIYYENLLDYVIENIVAEVDDEDVEEGLDVPVVVTGGTSSPSGFEALFRDHLEDANIPFSISGVSHANEPLYSVARGGLVAARSDEDVDHEEDDEAEAATTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M3R7</accession>
    <name>A0A3N6M3R7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86767">
        <property type="protein sequence ID" value="RQG86767"/>
        <property type="gene ID" value="EA462_16670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="262" mass="28535" checksum="2FAFCFDB76C098B9" modified="2019-02-13" version="1">MAGPARLCVTNQKGGVGKTTVAINVAGALNELGRNVLFVDLDPQGNATEGLGLLEAYDDEPPTLLDALIDPEAVSPDDIVHSHSEMDVVTSNIDMNAAASALARQSNAETLLEDLLDGIEEGYEYVIVDCPPHLGVLTDNALCATENLVIPALTEPTSKRSLELLFDYVGSLEMDHDVEIEPVALVANRIETTREDEEMLAWFEDALPDVPLYRVRKRVALQRAFTDGKSVFEADEETDMETVFTALAETLEDRFSTREVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4Q0</accession>
    <name>A0A3N6M4Q0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Outer membrane lipoprotein carrier protein LolA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_09500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90211">
        <property type="protein sequence ID" value="RQG90211"/>
        <property type="gene ID" value="EA462_09500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG90211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="29159" checksum="87AFE0C2CDDB0007" modified="2019-02-13" version="1">MGARRLPLVFCLLAVVVVLGGCAVLDVPSSDPEPDPETVFEAAFVHGDDLVDVRGERTTTVTDGDETVTEVASVVERPYVEYRSEVLESSMAATAGDVYVSNATASWWYDPESNAASVYEVDEPHENEAVEAARADQAERQLERYDLEYLGTETVADRETYVLTVEAKDEVVEDGISVLVGDTEYVYALETVDPADELVALEQTIWIDAEYEYPLKEELVFEGPNGERKTMTERFEEVSFNNDLPDGTFAFEPAENVTVDEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M679</accession>
    <name>A0A3N6M679_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88786">
        <property type="protein sequence ID" value="RQG88786"/>
        <property type="gene ID" value="EA462_10285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="104" mass="11399" checksum="22FBB7E4B28BD11B" modified="2019-02-13" version="1">MTSSDDGGYVHDPSAFSDGERRDGSAESDDSEWTDEPIHPDSADREFDWRGWILVGVIVFAFIVSPVAILLWPPDVGYLFALLILPLVPAVLLAVTAVWATTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M762</accession>
    <name>A0A3N6M762_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable GTP 3',8-cyclase</fullName>
            <ecNumber evidence="11">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">moaA</name>
        <name evidence="13" type="ORF">EA462_04100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="11"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91181">
        <property type="protein sequence ID" value="RQG91181"/>
        <property type="gene ID" value="EA462_04100"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_A">
        <property type="entry name" value="MoaA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013485">
        <property type="entry name" value="MoaA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02668">
        <property type="entry name" value="moaA_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="7 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RQG91181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="336" mass="38020" checksum="8733BBFC4DA79F0C" modified="2019-02-13" version="1">MLTDEFGREVTGVRVSLTDRCNFDCVYCHNEGLGDTRGPMDPQDDEMDTEDVVRFLEVVAEFGVDAVKFTGGEPMLRQDLEEIIARTPDEMEVSMTTNGTFLPGRADDLVDAGLERVNVSQDALDPDDFAAVTKSGAYDKVLEGVDAALEAGLEPVKLNMVVFEHTAGYVPEMVDHVAENDGLQLQLIEYMPELTGKPEWNIEIERVHDWLAERAVDIEHREMHDRRRYWVAGSDDEGTERSREDPGVGMVEIVDPVENPTFCANCHRVRVTHEGYLKGCLNRNDDLRTMGEMTNSEIREAFRETVENRVPYYGEYMIKNADGEWELNEKYLDAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7I3</accession>
    <name>A0A3N6M7I3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91301">
        <property type="protein sequence ID" value="RQG91301"/>
        <property type="gene ID" value="EA462_04755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="134" mass="14907" checksum="AF429229151E6BCA" modified="2019-02-13" version="1">MSDIRSQARTIWDAVYERVGGDLRAVIRYEPMDSGSVMRDDVRTQYAPDETQAIVDQTIVDQLSNRRQEHAFDAGQLSAVVRVFDEAWIVSCPDSPARKSGVLISIERDGDCASMADVEWCVGYLETECDSLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M868</accession>
    <name>A0A3N6M868_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZIP family metal transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_06220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91551">
        <property type="protein sequence ID" value="RQG91551"/>
        <property type="gene ID" value="EA462_06220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="266" mass="27832" checksum="440A3FD79C0AD400" modified="2019-02-13" version="1">MIPDGLGLVVAAGVFTAIVCGFGTLPFFFVDEISDRVTVALWGLAGGIMLFASLFGFVVEGLEEGTLTQVGLGLLVGIALVIAADRIIADYEFSPREMPDADFRKLVLIVGVLTVHSFPEGVALGVAFADLGVDGDLVLAGLTVPALAIFITVAISIQNVPEGLAVAIPLHTYGVSNWKIFGWAVFSSIPQPIGAGIAYLFVTFAREFLPFGFGFAAGAMIYLVVHDMFPEALDHGSELPGGGRRELAFGVALGVAIMIPVMAVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M883</accession>
    <name>A0A3N6M883_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91571">
        <property type="protein sequence ID" value="RQG91571"/>
        <property type="gene ID" value="EA462_06350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="107" mass="11905" checksum="E5F084CE9C8BE7BE" modified="2019-02-13" version="1">MTESDPTDEVRSLGVGTASRLFDEATFPVTTAELIAEFADVTISYPDRTDSLEAVLETSGHETYESQSDLELAILNGVRRDAIGRPRYSDRGDSPNELEYVRKQQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8E1</accession>
    <name>A0A3N6M8E1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_06690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91631">
        <property type="protein sequence ID" value="RQG91631"/>
        <property type="gene ID" value="EA462_06690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="214"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="302" mass="31937" checksum="0A5D0B2519EF6261" modified="2019-02-13" version="1">MTAAGVDEQTQFTRAAAVNVVGNAAKIAVEGAAGLAFGSIALLADAAHSVADLVASVVVLIWGRSSFDEPDDTHPHGHDRIEPLTALFVGAVLALLGLSLLYESVQGLAVSDPPDANPLLLGALAFAIVDMYLVYRYTEYVNAALESTALSALSTDCLNDIYTSMAAVVGVIGVLLGHPILDPLAGGLVSVLVIYQGVEIGRENVDYLIGAAADPDQYDEITRTLRSHPDVEGVHDLTVFYDGTVLEVEVHVEVDGDIPFRHAHDVESDLVSRLREVDEVGDAHVHLDPSGIGEWKDRANGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC09</accession>
    <name>A0A3N6MC09_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93021">
        <property type="protein sequence ID" value="RQG93021"/>
        <property type="gene ID" value="EA462_02070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="359" mass="40239" checksum="17A591833FB16AE2" modified="2019-02-13" version="1">MTDRPRSTRIAICSHFSLEHYRGGEKWVAALANLLSEDGFSVEVRTIPYSPGGVRRVSHRRVLDPDVSYAEAWHHDLSGVSSAYMMYAPGMRQAFRGSEFTVAGIHSWAFVSPTLVEPHYSPLHNGAKLFYRLVGERDLARYDRVHTVTPAFDGGDRIEPVYVPNFVDRRLFRPNRRPLADEFQVLVSAANVHRKGWDLARRTASLLEPSIRLVTTGTSDSPHVTGLGFLSERELADAYARSHAVLHPARVDTDSMVINEAGAAGTPVVTTPLETHVRENEAVLHAGTPRGMASLLEGLRSEWEAGEAYERRCRYARETSESRDVERVYPALKSLLLERADPEVGDRSDRSRVPPERRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC22</accession>
    <name>A0A3N6MC22_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91236">
        <property type="protein sequence ID" value="RQG91236"/>
        <property type="gene ID" value="EA462_04395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="110" mass="12003" checksum="3E387B3C08036755" modified="2019-02-13" version="1">MSTKASNTRPDQTGDPEAQLDVLGDTCARTIIVATSNGPKTAKELTERTESSSATVYRRINSLLESDLLAECIRFEEDGSHTTAYEATVEQLTVRIDPDGINVSLSRLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC70</accession>
    <name>A0A3N6MC70_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91296">
        <property type="protein sequence ID" value="RQG91296"/>
        <property type="gene ID" value="EA462_04730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="183" mass="20500" checksum="FC252ED7EEC4B31F" modified="2019-02-13" version="1">MRIRDWKDVLEDVADRNVDPEDWRAVAGDRAGGVGEDMYLAHPRAGVFFLKTYAKNPFEVRGVGTQVARSVDDEIGSYLPDRNDGGRFAVQSPPDDEDHAESVAKRLETVVETHADAPTRPQDFFDDVMEALESPAFGPMAYDQYDRPDELGDLSGEFDEAEQLLNAELDDLLETDEVDRGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCT6</accession>
    <name>A0A3N6MCT6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93321">
        <property type="protein sequence ID" value="RQG93321"/>
        <property type="gene ID" value="EA462_03070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="306" mass="34948" checksum="243E30123E1835A4" modified="2019-02-13" version="1">MGVKEPANAVFGLLSDETRVEILRAIAVAESEHENADPSPAELSFSEIYERINVDNTSKLSYHLGELTETFLRKSDDGYSFTHAGEQIVRFLLSGNYEKPADFDPQPTSGTCLYCGETTLIAQLHHQYFQIECASCERPVSAFPITPAQARSWTDNDLVDNVKQKQAIDYEQIRRGTCPECAGRLSTEVARLPESQRTETIRHLVVDRCRECLRRYNSPLTYRVAYHPASVAFHWDRGIDITSKGLWELHGHVYEGRWVSERISTDPDEYEIVLRYDGDILRIRLDSYATITHTERARSRDVADQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFW2</accession>
    <name>A0A3N6MFW2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Twitching motility protein PilT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92806">
        <property type="protein sequence ID" value="RQG92806"/>
        <property type="gene ID" value="EA462_00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041120">
        <property type="entry name" value="PIN_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18477">
        <property type="entry name" value="PIN_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="128" mass="14066" checksum="44BE32ACEC544682" modified="2019-02-13" version="1">MTTRIVLDTSALMMPVELDVRLFDELDRLLGSYELLAPQSVVEELRRLSEKGGAEGTAATVGHDLATERCLVVDTEASYADDALVELAREGGVDYVVTNDRPLRDRILETSVPVIALRGRNKLAITRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGH0</accession>
    <name>A0A3N6MGH0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93046">
        <property type="protein sequence ID" value="RQG93046"/>
        <property type="gene ID" value="EA462_02205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016873">
        <property type="entry name" value="Caps_polysacc_synth_BcbE_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028162">
        <property type="entry name" value="BcbE_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="236" mass="26341" checksum="B2AF758CE3529B76" modified="2019-02-13" version="1">MAGKGSRFKDAGISCPKHEVIVDDRPMFDWAMQSLKSFYDDEFVFITQAADSPSEFLAERCETLGIDRYEEVTLTEYTDGQASTALAADDSINDSQSVAIFNIDTYVEEGKLSPEIIKGDGFIPVFETTGERWSFVKEDSKGNVVSVSEKEKISDLATVGFYYFDQWSYFADAYAEIASETKSKYGETYVAPLYNSLIDSGESVETHCLDESAVHVLGTPQDLCSFYPEFDPNNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGP0</accession>
    <name>A0A3N6MGP0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF192 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93136">
        <property type="protein sequence ID" value="RQG93136"/>
        <property type="gene ID" value="EA462_02730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="163" mass="17731" checksum="6271E6B41C637448" modified="2019-02-13" version="1">MATGRVCKTLLAGVVLVLVVTLLVQASVVSTPWGQDRTTVTVLDDDGEPKATVEVEVADTLQERYTGLSDHDSLEAGHGMLFVHASEDDRTYVMREMDFDIDIVFIGGDRTVTSIENARAPEPGEDGEELRYSGRAQWVLEVPRGYANETEMAVGDDVAIDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRM2</accession>
    <name>A0A3N6MRM2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86913">
        <property type="protein sequence ID" value="RQG86913"/>
        <property type="gene ID" value="EA462_14735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="137" mass="14076" checksum="D07BBB4AA667DB88" modified="2019-02-13" version="1">MSERKETVRHGFAVAGVVTGLLAGGLVVLSGGLETTGERAMILWLAVAGGALFVAGVRERFPLGVVTVGWPRVAAFGLALLALGSSVIGFTQLFTGPSGLGILNVVVALFVAMYVGVVALECLLGGVRMDEETFVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MTF6</accession>
    <name>A0A3N6MTF6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AbrB/MazE/SpoVT family DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88085">
        <property type="protein sequence ID" value="RQG88085"/>
        <property type="gene ID" value="EA462_14650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="101" mass="11589" checksum="C96CDC554221548E" modified="2019-02-13" version="1">MSSSTRDPEVVRVSQKGQATIPKTLRKKFGIDTPGEVFIYEEDERIIVEPVPSLEELGGIHADTDHEHGDVLDRVRELKHEERRREDARADRLRPADSEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MUI5</accession>
    <name>A0A3N6MUI5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS5 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89062">
        <property type="protein sequence ID" value="RQG89062"/>
        <property type="gene ID" value="EA462_11835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="111"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="273" mass="31701" checksum="F6B19F56E22277D3" modified="2019-02-13" version="1">MQTLPKSRLLQFVEEAFQLAQRAVARYSSKFSKQRYTLHQHIVLLCLKVRKDTTYRTLLDELIEMPRIRNAINLTELPAPSTLCKAFDRLDMAVWRVLLNLSVSLLPTNGVVGIDASGFDRSHASKHYTKRAELTIQQLKVTLLVDTKLNAVLDLHVTTTRKHDSQIAPSLIKRNPETIDILLGDKGYDDQKIRRLARQHEVRPLIKHREFTPLHKAWNARLDADLYGQRSQSETVNSTLKRKYGAFVRSRRWWKQFRELTIACLVHNLDRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MWP8</accession>
    <name>A0A3N6MWP8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89912">
        <property type="protein sequence ID" value="RQG89912"/>
        <property type="gene ID" value="EA462_07835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="216" mass="23997" checksum="AEA4C8182042115A" modified="2019-02-13" version="1">MPSTVVHVAIAGMMGVALLGNRFDTKAILIVMGATALIDLDTLIGIYVPGTHRAALHNVWIVVIPAVVLAWDVKLRERSFVLERWGAYGYRVAWVTLVTVLFAHILLDAFFNGVNLFWPVHDRFYDLSGKLVVTDQRGLVQTFVEIDSSTGAVDESTTRGTTEDMHYSTGFDPTREEPPADVERIFPIAGTGERFVLTIAGFTTVLFRIVEDRRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0C2</accession>
    <name>A0A3N6N0C2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Probable cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobQ</name>
        <name evidence="11" type="ORF">EA462_04955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91332">
        <property type="protein sequence ID" value="RQG91332"/>
        <property type="gene ID" value="EA462_04955"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="9">
        <location>
            <begin position="5"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="10">
        <location>
            <begin position="281"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG91332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="549" mass="58102" checksum="9BBBA36D9BCE9412" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NU04</accession>
    <name>A0A3N6NU04_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_17045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86176">
        <property type="protein sequence ID" value="RQG86176"/>
        <property type="gene ID" value="EA462_17045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="192" mass="21207" checksum="015BB196199B5E3E" modified="2019-02-13" version="1">MLSNLAQGVQAFTSNVYLLKGQRTVLIDPGSNFDVVERIRDRVDGLDAVVLTHTHPDHVGNLAAVKDAFDADAWGYDASVDGVDHAIEDDESVRLGDHEYVALHTPGHKDDHLCFYSEEAGVLLAGDLVFQNGSFGRTDLEEGNREMLIRSIDRLVDRIDEDLEEMHTGHGPSVTVDPYDHVELSAEMARQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NU76</accession>
    <name>A0A3N6NU76_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">EA462_16240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86690">
        <property type="protein sequence ID" value="RQG86690"/>
        <property type="gene ID" value="EA462_16240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="302"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="385"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="7">
        <location>
            <begin position="447"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="736"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="346"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="444"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="525"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG86690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="785" mass="84750" checksum="E89B1B102EFA66D4" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWT0</accession>
    <name>A0A3N6NWT0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase family protein molybdopterin-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89029">
        <property type="protein sequence ID" value="RQG89029"/>
        <property type="gene ID" value="EA462_11655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="789" mass="84270" checksum="E86C708BD78FEBE2" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZU5</accession>
    <name>A0A3N6NZU5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NuoM family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_15880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87106">
        <property type="protein sequence ID" value="RQG87106"/>
        <property type="gene ID" value="EA462_15880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="4">
        <location>
            <begin position="132"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="508" mass="54676" checksum="548C07DF6AEBBC6B" modified="2019-02-13" version="1">MMIEAMIAVALIGALATFVAPNRLAGKLAFAISLVPVAISLWLFAAFDGSGNALLDGELAFESQYEWIQLGDYAITWFVGLDGISLPLVVLTTILVSLAIVSSWTPIDDRESQFYGLVLFIEANLIGVFVSLDFFLWFIFWEAVLIPMYLLIGIWGGPRRKYAAIKFFVYTNVASLLMFGAFIALVFGLGDSVSSFALPEIATAMRNGGLEGLFGIDGPTLASIVFVAMFIGFAVKVPIVPFHTWLPDAHVEAPTPASVLLAGVLLKMGTYALLRFNFTMFPDQAEAYAIPIAAIAVISVIYGAMLALAQTDLKRIVAYSSVSSMGYVILGLIAFTQFGVGGATFQMVSHGLISGLMFMAVGVIYNATHTRMVTDMSGMADRMPVAVGIFIAGAFGYMGLPLMSGFYGEFAIFFGSFGSDFLAYAPVFTVLAMFGIVIVAGYLLYAMQQAVFGPYSLETDYDVGRAPLHDVAPMFVLLGLIILLGVAPELIFDMITDAVDPILERGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0A5</accession>
    <name>A0A3N6P0A5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_13355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87848">
        <property type="protein sequence ID" value="RQG87848"/>
        <property type="gene ID" value="EA462_13355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="4">
        <location>
            <begin position="61"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="118"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="562"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG87848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="674" mass="74718" checksum="DD0E230EA4A4209C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P161</accession>
    <name>A0A3N6P161_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91219">
        <property type="protein sequence ID" value="RQG91219"/>
        <property type="gene ID" value="EA462_04305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="8"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="625" mass="69597" checksum="36D20766247D778D" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1R7</accession>
    <name>A0A3N6P1R7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89045">
        <property type="protein sequence ID" value="RQG89045"/>
        <property type="gene ID" value="EA462_11740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="2">
        <location>
            <begin position="48"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="159" mass="17304" checksum="15A96585F70F7149" modified="2019-02-13" version="1">MADCPLADDCPSFSERISGMGCQHYGDRGGKEWCQHYSQPIDDLKTQPVKSGEEVVIDVVDMHESGAGVGRTEDGFIVMVDGVLPEARARVEITRVHSNHARAEELEILPLEDDADEADGTDDERPVDGTTEADGTDSDGTASRGEREHLGSRENFWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1X0</accession>
    <name>A0A3N6P1X0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylglyoxal synthase</fullName>
            <shortName evidence="2">MGS</shortName>
            <ecNumber evidence="2">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mgsA</name>
        <name evidence="4" type="ORF">EA462_06210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91549">
        <property type="protein sequence ID" value="RQG91549"/>
        <property type="gene ID" value="EA462_06210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01422">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30492">
        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006614">
        <property type="entry name" value="Methylglyox_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00160">
        <property type="entry name" value="MGSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="55"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="122" mass="13256" checksum="B2B38FA03843EEB6" modified="2019-02-13" version="1">MTRLALIAHDEKKPDLVDFARTHESQLDSYELIATGTTGKRLMDETELEVERKESGPLGGDLMIGSEVAEGALDGVVFLRDPLRAQPHEPDISALLRICDVHDTALATNLSSAAFLIEGLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3F9</accession>
    <name>A0A3N6P3F9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_07285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89815">
        <property type="protein sequence ID" value="RQG89815"/>
        <property type="gene ID" value="EA462_07285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="26"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="253" mass="27184" checksum="A8596F3770D3B247" modified="2019-02-13" version="1">MIQRVLRQSPSRSSETDSDNASIPAVRLENVSHEYGDTGGRLRSGPDRAVRALRDVTVTCDRGEIVGLQGPSGSGKSTILHAISGLLVPSEGRVELLGTDLTKLSDRKRTRHRRQHVGIVFQRFHLLPSLSARANVALPLVQLGVPRSRRRTRATTLLERVGLAERITHLPSELSGGERQRVAIARALATDPDVVVADEPTGELDTATGAEVIEVLTDVGSDRVVVIASHDDDTLSAADRVVTLRDGAVVPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3I2</accession>
    <name>A0A3N6P3I2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89845">
        <property type="protein sequence ID" value="RQG89845"/>
        <property type="gene ID" value="EA462_07455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="209" mass="23272" checksum="4C50628D97A4487F" modified="2019-02-13" version="1">MWPWEHAIVGYLAYSVFSHCYYRRSPDGLEAFTAVFASVLPDLIDKPLAWEYGVFTTGYALGHSIFFAVPLSIIVGLLARRARRTGVGIAFGLGYLLHLPADVLDGYLRGGRVRTELMLWPVETVGSADERTGFSAEFLRLFGRYQQELLAGELSTYVQLQLALAGVVFALWIVDGAPVLRECLVGSKRLLRRLLGRSERSVPSSDERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3N2</accession>
    <name>A0A3N6P3N2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="10">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ctaB</name>
        <name evidence="12" type="ORF">EA462_07900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cell membrane</location>
            <topology evidence="3 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="10"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89925">
        <property type="protein sequence ID" value="RQG89925"/>
        <property type="gene ID" value="EA462_07900"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG89925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="472" mass="49359" checksum="28C0A88822068A5B" modified="2019-02-13" version="1">MVSESFPSPIGTRRRFSGLLAATALGVYLLLIVGATTSLTDATSACSTWPTCHLPADPLNQTQLAIAWGHRIAAVLVGLLVAATVVAAVLGDVSRRVRWAILAGGTLYVVQVGIGAATATLGPAAITPGLHLGLGIVIFTSIVLALAWDLETETGSDDELQTPSPAPIESGSTAQARSLPSSRLTRRRLTAFAYFKMMKPRLMWLLCLVAAAGMALAAGPDLTPDVIVATLGGGVLAIGASGTFNHVLERDVDQRMSRTADRPLATELVPVRNAIAFGGLLTVASLSVFLTINTLAAALGLAAILFYSVVYTLLLKPNTVQNTVIGGAAGALPALIGWAAVTNEIGMPALALAGVIFLWTPAHFYNLALAYQDDYARGGFPMMPVVRGETETRKHIVYYIAATLVGTVGLAWITDLGVLYAATVAIFGGIFLWTAVTLHFEQTESAAFRSFHASNAFLGAILIVIVVDALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3R7</accession>
    <name>A0A3N6P3R7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89975">
        <property type="protein sequence ID" value="RQG89975"/>
        <property type="gene ID" value="EA462_08185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG89975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="456" mass="48473" checksum="CB8F663817007232" modified="2019-02-13" version="1">MTADFYDLLEIPPDASPDEIKDAYREKVRVYHPDVNDDDRARAQFTAVKKAHDILGDPTERKAYDRLGHREYVAKRTSGIPSPDVWTNTSETSTESGERRESTTRTRPGRSSSETAEDESTAGTGSTTSDPRSSRSRRSSTAASTRGAVGSDHEATATRTEDVTTSATGTRTTSTGTSATSASGRATASSAGADSTTAATEDHGVSSTDGGTAHGHRRSQHSRRSDARRTGRIDGLVRWWRRRNVALPAIWLAVLVYVAGLGHAVSENEAAVDTLRAELAAVGGDVEGVLSVLSSGRYGLDSSIGFVSSVELVPPFLESVPSTAVLAGIVGVAFAVVLFARLRWREDTWGPITIDETILIALAVTVPTSMVGGPLLSGAVLMPFLFGVVVYHTRRGPGWQPSYLYVLPVLAPALGFAAGLIGEVSLVFDLVAFVLLPMIGALGLPLRATIRKHMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3T6</accession>
    <name>A0A3N6P3T6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90005">
        <property type="protein sequence ID" value="RQG90005"/>
        <property type="gene ID" value="EA462_08340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="130" mass="13920" checksum="9C5E435D0BFD4649" modified="2019-02-13" version="1">MSPYTLLLVEDSEFITQHVSQTLESKHGFEIETVPTATGTRDALEDGSFDCVISSYELPDETGIDLAASINGRTGSPAVPFILFTGNPLESLAEEALTSGVSAFVSKSSHATGDMNVFANRIRLTIQAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P461</accession>
    <name>A0A3N6P461_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KEOPS complex Pcc1-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90135">
        <property type="protein sequence ID" value="RQG90135"/>
        <property type="gene ID" value="EA462_09095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="121" mass="13214" checksum="1E278A23B5CB978B" modified="2019-02-13" version="1">MSRRPTDPATSRRATIRTRNDDPELVARALRPDNTDEMETDVEHSGATGRSESGTERAGRVVTRIERESTAGLQSTVDDYVVNLAVAIDVAHGGRDEQCGKPTDAGEVSDNESEYDTIHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P480</accession>
    <name>A0A3N6P480_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92709">
        <property type="protein sequence ID" value="RQG92709"/>
        <property type="gene ID" value="EA462_00290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="80" mass="8352" checksum="8A3F3C3BE510E1E5" modified="2019-02-13" version="1">MTSIGPELLVELLPILAYTLIAAVLTAGGLAAEYASLQHLGSGEAMVALWLAAIGAVMLYAGLYGIGYRKVFLRVIASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6X4</accession>
    <name>A0A3N6P6X4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_06720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91635">
        <property type="protein sequence ID" value="RQG91635"/>
        <property type="gene ID" value="EA462_06720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="207" mass="22871" checksum="92A4106FD4AB9BA9" modified="2019-02-13" version="1">MYVRDAKNREEVWLLDHIEAMGLDDTAFRSRDYVVAIDEESGEKGGFGRIRTHKVDGSSTDGDADRASANGDDVCELTSIGVLEGWRDQGIGAHVIERLVDYASDQGFETVYTLTGSGSYLAQFGFERIDESQLPAPLRGRLEAKRDGVDPDAVPLAIDVDAFRMPERLREAFKQAPTGRDDVSSDEPPEDFGIDPDTATYKYDTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9B3</accession>
    <name>A0A3N6P9B3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit Rpo7</fullName>
            <ecNumber evidence="5">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpo7</name>
        <name evidence="5" type="synonym">rpoE</name>
        <name evidence="8" type="ORF">EA462_00830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92805">
        <property type="protein sequence ID" value="RQG92805"/>
        <property type="gene ID" value="EA462_00830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00865">
        <property type="entry name" value="RNApol_arch_Rpo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046399">
        <property type="entry name" value="RNApol_Rpo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="PTHR12709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="SSF88798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="82"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG92805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="189" mass="20831" checksum="D8475DBF0B7F2EC5" modified="2019-02-13" version="1">MYKRVRLTDTVEVPPEELGDVSPALVKRLLQDKLEGRMDEEVGSVVSVTHVRDIGKGTVLPNRPGVYYEADFDAVTFDPQMQEVVDGTVVEVVEFGAFVGIGPVDGLLHVSQISDEYLAYDRENQQLASNESNRTLGVDDAVRARIVTKSIDERNPRDSKIGLTAKQPGLGKHGWLTEDHEKQEATAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9D2</accession>
    <name>A0A3N6P9D2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_01000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92835">
        <property type="protein sequence ID" value="RQG92835"/>
        <property type="gene ID" value="EA462_01000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="1">
        <location>
            <begin position="57"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="286" mass="32890" checksum="2B1B1D379866EFB1" modified="2019-02-13" version="1">MNEDGVERLFEHVRNAERLRSDVYEEVTATILESKLQQISDVHTVRHHHNLECDFGYKQMDVYLQLGDGEDEITAIVECKGRNSPMEKDHLASFAFYLEHSDADKGIYVSRSGYRSGAKRIAKECGIQLFEISQITDGAIKSVDGTFTHRFGPYRHHVFVKDPKSQDWMKLSEGLYSIHEQLELPILDRSGDPTGDTLEDRLPGEEEEGTVEIEFEDGEMVQVNGNEYELWQAISHPQPDGGDGSSFKVDFEDRIDLKLRDVLADQSEYVLFDDIKRQFLRIEREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9Q8</accession>
    <name>A0A3N6P9Q8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93005">
        <property type="protein sequence ID" value="RQG93005"/>
        <property type="gene ID" value="EA462_01985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043852">
        <property type="entry name" value="DUF5814"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19131">
        <property type="entry name" value="DUF5814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="151" mass="16846" checksum="61EA0B5ED812D30D" modified="2019-02-13" version="1">MAITDKIYVKNHRQLSSQLETNIPKGAFKGATLDVLFQGAGLEKLDEATRDRVLDFAGDFLDCDCDNNPYCGCPERKFIRYLLELRAQGLGPNAIVDVMSDDYMVYAYTGDVLSFLDNGVRTLEAAEGLARVDGAGETTDEIRREKRNLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9Z4</accession>
    <name>A0A3N6P9Z4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93135">
        <property type="protein sequence ID" value="RQG93135"/>
        <property type="gene ID" value="EA462_02720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="114" mass="12721" checksum="8C26BD21093B8A2A" modified="2019-02-13" version="1">MSDDDRERGVGLGDVRDALERREYPVSQAELLEDHGDEVIETGEKTTTLAELLEPLNEDEYESFEAVETAIMNMVGDEAIGRKNYSDRTPPASGEERQDEGAPGQDGQREQESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6PAB4</accession>
    <name>A0A3N6PAB4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_02810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93315">
        <property type="protein sequence ID" value="RQG93315"/>
        <property type="gene ID" value="EA462_02810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG93315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="139" mass="15297" checksum="F479983D0AA817AF" modified="2019-02-13" version="1">MRGNPLDELEEMLNRVSRQVEEGMTGGGLQVPGSVPVDVADRDEEYVVTADLPGYETDDMSLTLSDGTLHLEATRADEEEYDGGRYLRRERTRTAASRRIRLPEPVEEGSISAGYEQGVLTVRLPKAGGGDESKEIDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LIS3</accession>
    <name>A0A3N6LIS3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_13405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87856">
        <property type="protein sequence ID" value="RQG87856"/>
        <property type="gene ID" value="EA462_13405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG87856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="259" mass="29127" checksum="5A14BD445E0E2D69" modified="2019-02-13" version="1">MNDGKVTIEKLGKVYDDGPEKTKAIKDLTFEIAGGEFVSIVGPSGCGKSSLLYLLAGFLETTSGSITVDGNPIDGPGTDRGVVFQDYALFPWRTVLKNVTYGLEQKGMPKEERRSTAQRYIDMMDLSGFEDRYPKELSGGMKQRVAIARTLAYDPKILLMDEPFGALDQPLRESLQDQLLDIWKELEKTVVFITHDVEEAVYLSERVMIMTSHPGTKKTVVPFDIDRSLNREEIITTDEFISTKNTVWMSLREETQPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ10</accession>
    <name>A0A3N6LJ10_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88016">
        <property type="protein sequence ID" value="RQG88016"/>
        <property type="gene ID" value="EA462_14265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="414"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="605" mass="68251" checksum="9BD29A5A2023BA11" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ49</accession>
    <name>A0A3N6LJ49_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine dehydrogenase family protein subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88096">
        <property type="protein sequence ID" value="RQG88096"/>
        <property type="gene ID" value="EA462_13290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="296" mass="31753" checksum="939ACAC7AD482E9A" modified="2019-02-13" version="1">MKSEPFVYHSPVSVEEVVSLMNEHDHAELVAGNQSLAIQMNNRLATPDHLIDLNDVDDLAYLDERDGAIEIGAMTTHNTIAESDVIDRKLPILSEAARQIAGPSVRNVGTLGGGIGEADPAGNYPTVLTALDATITLTSESGDRSVGVDDFFIAYMMTEVGENEMITGATVPTDPFPIGRTGMSFLELKRVSHTWPKLSAAGIVRVDDPTASEPTVEEARLTFANASDTPLRVEAAESAIEGTSLTDDALDEAAGIAMDSADPADEMQAEAEYKEEQVGIFTERALREAYDRALDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJT5</accession>
    <name>A0A3N6LJT5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-oxoprolinase subunit PxpA</fullName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="1" type="ORF">EA462_11615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89023">
        <property type="protein sequence ID" value="RQG89023"/>
        <property type="gene ID" value="EA462_11615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="255" mass="27611" checksum="5B5DC52CFACF3EA8" modified="2019-02-13" version="1">MTGIDINCDMGESFGNWTMGNDADVMPYVTSANIAGGYHAGDPHVMRETVELAADHGVGIGVHPGLPDKVGFGRRTMDASPAEVRDYVVYQLGALAAFARRHGTSVQHVKPHGAMYSMLSDSAEHARAVMEGMLEVDEDLIYLATDMNIHEVAQQVDGLRAVFEGYVDLDYRADRSLIVEQELSDRDPDLVADRFVSIATDGVVEAANGEEISVPADSICIHGDNPNAVELLEAIHERIDDHDIELVGLPELVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJV4</accession>
    <name>A0A3N6LJV4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase archaeal subunit H</fullName>
            <ecNumber evidence="2">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ahaH</name>
        <name evidence="2" type="ORF">EA462_11790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89053">
        <property type="protein sequence ID" value="RQG89053"/>
        <property type="gene ID" value="EA462_11790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014275">
        <property type="entry name" value="ATPase_A1A0-cplx_hsu"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02926">
        <property type="entry name" value="AhaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="110" mass="12835" checksum="1BCBB78A4780D5A2" modified="2019-02-13" version="1">MPRPEVLKRITSAEEEADEIVAQAEDDRDERIAEARERAEEIRTDAEEDARDLKERRLEEARDEIDEECERILEAGEQERIALSERAQDRVDDVTDHVVSLFQEDVNVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LK46</accession>
    <name>A0A3N6LK46_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_11185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88948">
        <property type="protein sequence ID" value="RQG88948"/>
        <property type="gene ID" value="EA462_11185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="374" mass="41257" checksum="547946CD72E67653" modified="2019-02-13" version="1">MEYVQERIATLHDLDGNATQTAVDGRLERTVARTAVVVPMTAREHESPAATAVLSELEHLGLAAVFVPVRAPVDRIGPIREWLESFDLPMRVLWCNAPTVETMLADVGLSNGFGKGRDVWLALGPAATAAEFVVVHDADARSYERGHVHRLLAPLTMGFEFSKGYYARIEEERLYGRLFRLFYEPLIGALATDHDAAILDYLGAFRYALAGEFAVTGTLAQRLRPPRAWGLEVGTLGDAFDHAGFVGTAQVDLGRHVHDHRAVAGETGLEGMSREVAASLLRVLEERGVEPTYETLPERYCAVGDRLIEQYHADAAFNGLEYDPAGERDQLARYAESIAPPGLDRRLPPWTDAPVDPDAVLRTTRPWLEEEASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKK6</accession>
    <name>A0A3N6LKK6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor 6</fullName>
            <shortName evidence="3">aIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eif6</name>
        <name evidence="4" type="ORF">EA462_15110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86978">
        <property type="protein sequence ID" value="RQG86978"/>
        <property type="gene ID" value="EA462_15110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="PTHR10784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="221" mass="23093" checksum="B9E3538E327E680D" modified="2019-02-13" version="1">MQRLAFAGSSYVGVFARATDSCVLVRHDVDDDVLAALEDELEVPAIPTTVGGSSTVGALATANENGLLVSSRILEYERDRLEDELDVAVAELAGNINAAGNVVLANDYGAYVHPDLPRETIQTVKDTLEVPVERGDLAGVRTVGTAGVATNSGVLCHPKATDDELDLLEEVLDVRADVGTINYGAPLVGSGLLANEAGYVVGEDTTGPELGRIEDALGYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKN8</accession>
    <name>A0A3N6LKN8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87028">
        <property type="protein sequence ID" value="RQG87028"/>
        <property type="gene ID" value="EA462_15410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="384" mass="43052" checksum="84B778BD24DC6C75" modified="2019-02-13" version="1">MTDDNDVYTPAQYREHQDGYGVRDAHEHRHTGIVRDELVSRFLSIQAENYDPLEADEPGRMPGEADTLEESREILAIGGTETARSALENGDMPTLKHLTGDQQERADISGLKAIQQVDEIIEDPAPVIVIIGDMGTGKTDLACLLAQRAKHLLGIEKVASNVPTLRETNQWVDEDGETRDGFVPNWRSMEQWVQQDGDPLEDDQRGKLFIGDEFSSGGDGTGKSGYLMRKKMGPLVFKIRKYDGMLIYVAHDESSIHPLLWRVGYVIKKESKKRATVADKIKSGEVRDVQFEIDGIPATDWRYNTKDPAVWSWTGAEDDDDPEPGEIAYDVAVWTVKACKEDGLSHRETAKFVPFGKSWVGDRWPEIQDGEHRSALDRVEAVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKP2</accession>
    <name>A0A3N6LKP2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87038">
        <property type="protein sequence ID" value="RQG87038"/>
        <property type="gene ID" value="EA462_15470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="130" mass="14378" checksum="8BCC6479810563D9" modified="2019-02-13" version="1">MVDFTLQMLQFLGILIPVLFAAVRLTQTSVENDNEGKLLPDSIRYRTEKLEEGAGKIYRYIPYSSLLFLCTLIPFSVAALLLTVDLGYYLVNDEGSTALPLLAVGLQAFGILGLTAFLIHNTPRKAAHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLZ7</accession>
    <name>A0A3N6LLZ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90083">
        <property type="protein sequence ID" value="RQG90083"/>
        <property type="gene ID" value="EA462_08775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="5"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="207" mass="21967" checksum="B4F36B8C8276777C" modified="2019-02-13" version="1">MFEDRADAGDRLAAELERRGLEADVVLGIPRGALPVAKPVANALEADLDIVVARKMGAPGNPELALGAVASDGTVWRNDALIDQLDVSEAYVEDVRTMEADNAREKLARYRETDELPDLAGARVVVVDDGVATGATATACLRQIREADAASLVLAVPVGSPSAVDSLRSEADDVVALRTPENFRAVGQFYRTFGQVSDADAIDYLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LM57</accession>
    <name>A0A3N6LM57_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90058">
        <property type="protein sequence ID" value="RQG90058"/>
        <property type="gene ID" value="EA462_08645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="223"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="431" mass="46338" checksum="09A2D1F578E29FC2" modified="2019-02-13" version="1">MPEPQIATIDVRRQFHAYPEPSWCEFYTTSRLVDYVESLGVDEVFVGDETLDVDERLGVPDESTLEHWYDNAAAMGARSDVLESTAGGNTGLVAVVERGPGPVVGLRVDIDALPFEEASDSSHTPAADDFRSENTGVMHACGHDGHMAIGLGVLETLMHEEFSGTLKVFFQPAEEVLGGGRAMAATRHTADLDAFFAVHLGLGHPTGEIVGGSDRPLALRQSRATFHGESAHAGFAPNEGRNAMQAMSTAIHNLYGIPRHEDDLTRVNVGRARAGAASNVVADSATIDLEVRAGTNDVLDYMLSHVDRMLEAAACMHDCSVSTTTIGRAPRVDSDGVLSELVADVASRHPGVSSVKRHAPFGASEDTTYFMRRVLENGGNATYVIVGTDHPSGHHTPRFDIDERSLEIGRVVLSDAIFRVLTGERAQDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LN21</accession>
    <name>A0A3N6LN21_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metal ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_15020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86965">
        <property type="protein sequence ID" value="RQG86965"/>
        <property type="gene ID" value="EA462_15020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG86965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="321" mass="34125" checksum="9652E56406F17C6A" modified="2019-02-13" version="1">MATEQHSRIPRTAGLIATIPVAIAALYVIMYVLFPPLFERFWGATCGTVDTWLVCSSFVQHGFTAGVLIGVTAPVVGAYLVNRQMALIGEALAHMAFGGVAIGLFVGAAVPSADYPLLFALVAATIAALCMQYIAIKTDGYADIPIAIMLTGGFALGIAVISYGVTFHSTVESYLFGDILFVPFENVQLMVGLTLVVIGTITLTHKQLLFITFDREAARLARIDVRFYDTLLIVLTALVVVAAMQILGAILVAGMLVIPVAAAMQITDSFNRGLILSVAFGQIAVFVGILLSAWWNIATGAMIILVAIALYFASLLARMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP85</accession>
    <name>A0A3N6LP85_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II histone deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88077">
        <property type="protein sequence ID" value="RQG88077"/>
        <property type="gene ID" value="EA462_14610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="1">
        <location>
            <begin position="39"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="383" mass="42022" checksum="F96FFED3E8C27483" modified="2019-02-13" version="1">MSSQSTLSVYWDDSFLEHNPPAGEFELASSGRLAVDEPHPDRPERVQNIKHILDHELSEFLEWQSVEPATIEQLSRVHTASHISEFEEFCKNGGGRITAETGANEASYTAARHAAGASIQAATDAMRTDVSERVPYALVRPSGHHAQPDQIDGFCFFNNVAIAAEHLRATDQAERIAIIDWDVHHGNGIQETFYDRDDVLYVSIHNDHWSWDPDAHPQTGNTRENGTGDGVGYNVNIPLPPGAGDKGYEYVFNSLVSPIVESFDPDVLLVSAGQDAGTMDPLGRNVVTKSGFEAMGQRVRKLATECADGHLALIQEGGYHLSHLGYATLGVLEGVLDVRTDVREDPFAWLDEDLDSVVSATHSVGADHAHHWPLSFTPSTERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LP86</accession>
    <name>A0A3N6LP86_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable aminomethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">gcvT</name>
        <name evidence="8" type="ORF">EA462_07860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89917">
        <property type="protein sequence ID" value="RQG89917"/>
        <property type="gene ID" value="EA462_07860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="6">
        <location>
            <begin position="9"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="7">
        <location>
            <begin position="285"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG89917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="365" mass="40258" checksum="A38CC0F46F0905B2" modified="2019-02-13" version="1">MPIQTPPLRAVHDERGAKFTAFGGWDMPVEFDSIRTEHAAVRENAGRFDVSHMGQIHVTGPDSTTLMQRLTTNDVARLEVGDAQYATITDEDGIIVDDTVVYRLPDETGDATYLFVPNAGTDEATHERWLAYRNEWDLEATVDNCTDEYAMFALQGPATPDLVDEETEGSVTELARFEAKYAEIDGIECWTARTGYTGEDGFELFVPWNEAERIWSAFDCQPCGLGARNTLRIEAGFLLAGQDFDRESNPRTPYEAGVGFTVALETEFVGRDALARISEEDLDERLVGLQLIDPGIPRHGYDITSTEGRVVGTVTSGTMSPTLERAIGLGYVPTAYAEPGTTVHVVVRGRSKKARVETMPFIDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPA5</accession>
    <name>A0A3N6LPA5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">moaC</name>
        <name evidence="6" type="ORF">EA462_08025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoaC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89947">
        <property type="protein sequence ID" value="RQG89947"/>
        <property type="gene ID" value="EA462_08025"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01419">
        <property type="entry name" value="MoaC_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_A">
        <property type="entry name" value="MoaC_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023047">
        <property type="entry name" value="Mo_CF_biosynth-C_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="5">
        <location>
            <begin position="37"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG89947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="177" mass="19102" checksum="FFA6E059CF753C0C" modified="2019-02-13" version="1">MSDGAREPADDGEGGDEFGDSSANDLTHTTDDGDVQMVDVGQKPDSERRAVAAGEIHLRPSTIDAIREDQVGKGDVLATARIGAIQAVKHTWETIPMCHQIPITNVDTEFSLSEARIELEVAVETTGKTGCEMEALEGVTTGLNVVWDMVKAVEKDDDGQYPETGVENVHVRQKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPB5</accession>
    <name>A0A3N6LPB5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytidine deaminase</fullName>
            <ecNumber evidence="5">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cdd</name>
        <name evidence="10" type="ORF">EA462_04660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="5"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91283">
        <property type="protein sequence ID" value="RQG91283"/>
        <property type="gene ID" value="EA462_04660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG91283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="132" mass="14338" checksum="82C75B58289B0F90" modified="2019-02-13" version="1">MSDSELLEAAREVQSAAHVPYSEYRVGAALETADGEVFVGCNLENANYSNSLHAEEVAVAEAVKTGYREFSRIAVSSDRRDGVTPCGMCRQTLSEFCDDDLAVICDEGDDQEPTVYALGELIPNTISHETLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPJ8</accession>
    <name>A0A3N6LPJ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdenum cofactor biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_10275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88784">
        <property type="protein sequence ID" value="RQG88784"/>
        <property type="gene ID" value="EA462_10275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43232">
        <property type="entry name" value="PTHR43232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="27"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="212" mass="22425" checksum="6330D6479CC179D7" modified="2019-02-13" version="1">MNETEQQASSEATGQESRAADPTLGVATVTIASSRTLASDSAGKAIETAIERTDHELTTREHVGTDHDRVQSIVSRVIERDDVDLVVTAGATSVEPTDIAIEAVEPLLEKKLPAFDHLFTSLAYEAVGTRVVAARTLAGVAEETPVFCLPGDEAATRLGIEEIVLPEATHLVDLARADREREETYGTDDGDEPMGNERDDGSSGGGTTGGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPU2</accession>
    <name>A0A3N6LPU2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2391 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88924">
        <property type="protein sequence ID" value="RQG88924"/>
        <property type="gene ID" value="EA462_11050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="189" mass="20449" checksum="2D5B197EA518954E" modified="2019-02-13" version="1">MSDPDGIPEAATIDDIYEQLEALEETVDDPTEQTEVRRTMTLLDRVAHNGAVGRVITEFTGKDKAEAFLGSVIIGMPLLVEDGVIEIGEFLAETPAFFVANGALAVVMVVGILYIADFREVRITDPYLGVVPRRPLWVLGIACGTATAMMTLWGRVTWEDPWVNLCQVSVIVTAMAIGGSLGDILPGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPV0</accession>
    <name>A0A3N6LPV0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88934">
        <property type="protein sequence ID" value="RQG88934"/>
        <property type="gene ID" value="EA462_11110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="123"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="277" mass="30973" checksum="4DC89C37499A0093" modified="2019-02-13" version="1">MLELEHGFRVVDVYTQLTPDGGNGPVQRPVVSPDQLEREMHQAGITKSVVFPPSRPETSYVAANNGVARRSVDRPFVAFARINGTKQSERCPTGRLHNAVSRRKEYHTTPGDIEKYAYDDRFHGFVLDPTIDEYPDDDVLAVLEDVGLPLLVRGGVDAPPEAIADALLGRSFPVIVAHFGGYPLERSLMNEMIDLLGEYDDCYLETSFVRYRELLERALLEHPDRVLFGSGAPSCHPDVAVMEILTLDVTEDLLWRAFSKNACRVIDALTPDTELRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LPX2</accession>
    <name>A0A3N6LPX2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_06420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91583">
        <property type="protein sequence ID" value="RQG91583"/>
        <property type="gene ID" value="EA462_06420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="100" mass="10655" checksum="4E949A2B138E87D8" modified="2019-02-13" version="1">MILSTALFVVLYHGFEGTEGLTGFPNVGTWLIFGVVLLPVYVMVIAWFVGTPRESTAGVRGVGYLVGITVTMWVSMLILTILIGISFFGGSPEPFSSPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ07</accession>
    <name>A0A3N6LQ07_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0145 protein EA462_06710</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91633">
        <property type="protein sequence ID" value="RQG91633"/>
        <property type="gene ID" value="EA462_06710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="104" mass="11315" checksum="6830EA3C2C33745B" modified="2019-02-13" version="1">MRITNTETVPDREIVETLGIARGNTVEARNVGRDITQGIRNVFGGELKAYSDLLTKARDEAISRMEADAEEMGADAVVNVRLETSQITDGGSEVMAYGTAVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ08</accession>
    <name>A0A3N6LQ08_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AarF/ABC1/UbiB kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89004">
        <property type="protein sequence ID" value="RQG89004"/>
        <property type="gene ID" value="EA462_11505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="97"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="547" mass="62474" checksum="9643F8E557239F02" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LQ70</accession>
    <name>A0A3N6LQ70_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nadE</name>
        <name evidence="9" type="ORF">EA462_11950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89084">
        <property type="protein sequence ID" value="RQG89084"/>
        <property type="gene ID" value="EA462_11950"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="8">
        <location>
            <begin position="33"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="282"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RQG89084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="299" mass="32691" checksum="32F52ABFECB9FCA4" modified="2019-02-13" version="1">MGVDSRTFVYPRSGVENGSFITSREELEEVRTRLTDHVRATVEDADAAGVVVAMSGGIDSTVTATLAVDALGSDRVLGLGLPCHKTERAAVSEARTIAEGLGIEFHDVQLRPLLAAFEETFAGELEEASSAEQPTQRPNERNYAIGNAVARFRMLCAYYVANRRSRLVLGTANRSEWLLGYFTKYGDGAADLYPIGDLYKTEVRALAERIGVPRRIVNKEPTAGFWAGQTDASELGAPYEVIDPFLTRIVDERLSIEDAADELEITLETARTIALRCSETAHKRTLPPTPGIDGRTDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRU5</accession>
    <name>A0A3N6LRU5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF63 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91177">
        <property type="protein sequence ID" value="RQG91177"/>
        <property type="gene ID" value="EA462_04075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002749">
        <property type="entry name" value="DUF63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40700">
        <property type="entry name" value="PTHR40700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01889">
        <property type="entry name" value="DUF63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="375" mass="40392" checksum="B19E386D7E9B26C3" modified="2019-02-13" version="1">MYEYVERYGPARVWAVTVGLLAAVVTLAAIAFPQRVYVDLIWQYYWGPVVADAHGWGCIAWAGGEQVQCAQAGADAGPTASPGYTFVSYAGYIPTLILFLAGIVLLVQRLAIDRYRAGFYALFPFMLFGGALRVVEDANVAAYRETGELAIQLPWSGFLISPLIYFTVFLVTLVAVVVSVWLEQNDSVSGYEYPLAAIGTGLVAVTVGYLGYIAAVEPYATFYPLLLLTTLVGATIATGITWLAIEQFAPGINRGTRYMGIVVIWAHAVDGVANVIGLDWAVAFGHSHNLIPKHPVNEAIVNVTGSMLPQSVVDVTGAAWPFLLVKLAAAVVVIWIFDETVFEDSPRYAILLMITVVAVGLGPGTRDMLRATFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LRV5</accession>
    <name>A0A3N6LRV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_07895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89924">
        <property type="protein sequence ID" value="RQG89924"/>
        <property type="gene ID" value="EA462_07895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="333" mass="37009" checksum="A287BED8167391AE" modified="2019-02-13" version="1">MEYTTLGNTGTTVSTLCYGTWRFGRNTGGVVETDREEAHDLLDACWDSGINFIDTANVYGDPDGTSETWIGEWLEEYDREDFVLASKVYFPFDGWGDPRPNDSGLGRKHIRRQIDGTLERLGTDYLDVYYIHRWDEDTPIRETLRTLTGLVEEGKVHHLGASSMAAWQLAKALWQSDVEGLERFDVTQPMVNAAEYDAVAEYLDVCADQNLAVCPYSPLAGGFLTGKYDRAPDGSVEAPDGSRGSLDDVFDDWYATEQAWDVLDEVQSVASEVDATPAQVSLRWLMDQERFTCVPIVGARTPDQLAENVGAVDVGLTDDQFERIGSARGDGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS07</accession>
    <name>A0A3N6LS07_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_08330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90004">
        <property type="protein sequence ID" value="RQG90004"/>
        <property type="gene ID" value="EA462_08330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="36"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="254"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="942" mass="103196" checksum="DDD7CAD1E19B4454" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS95</accession>
    <name>A0A3N6LS95_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_00615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92768">
        <property type="protein sequence ID" value="RQG92768"/>
        <property type="gene ID" value="EA462_00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0020" evidence="1">
        <location>
            <begin position="190"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG92768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="369" mass="39076" checksum="1787B257C6773ECA" modified="2019-02-13" version="1">MYLLEFAGEDDPFAAREAASAATGVRRIAPGVATARGVAPERVRGLAYTHRASALLGRTDAERESARALLEATPLERTGTVAVRATDVRGSSGVDTERVERDLGQVLVDRGFGVDLDDPDHLLRAIFSTGRLEGGSLAVDESTGDLITSLESTGDGETDGPRDERVSICALGWLETESVRDFGTRAPTDKPFFQPGSMDPLLARAVANVAGAEPDRTVLDPMCGTGGILVEAGLVGADVIGTDAQAKMVDGARANLAHFLESPALSPTGVDRGGWHVGRGDATRLPLRDGAVDGVVFDAPYGRQSKIDAHRLEDLVAGALAEARRVASRAVVVADRSWASEARDAGWELEAAFERRVHRSLTRYVLILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSJ7</accession>
    <name>A0A3N6LSJ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_09860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90274">
        <property type="protein sequence ID" value="RQG90274"/>
        <property type="gene ID" value="EA462_09860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="121" mass="13088" checksum="A25B8546E88AC9FA" modified="2019-02-13" version="1">MAERYSSFAPGGTAWLLQRVTAAFLVVVLAFHFFQLHFVNHAADVTFLGTQARMENVGYFLTMVLFLIAGTFHGVNGVYNALVNQGLEGTQKKIVLAVLTIASVALIVQGIWVALAMAGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSM2</accession>
    <name>A0A3N6LSM2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PsmA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">psmA</name>
        <name evidence="7" type="ORF">EA462_10025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90304">
        <property type="protein sequence ID" value="RQG90304"/>
        <property type="gene ID" value="EA462_10025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03756">
        <property type="entry name" value="proteasome_alpha_archeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_A">
        <property type="entry name" value="Proteasome_A_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019982">
        <property type="entry name" value="Proteasome_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03633">
        <property type="entry name" value="arc_protsome_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="6">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="253" mass="27427" checksum="AE69663F388DA8A0" modified="2019-02-13" version="1">MQGQAQQQAYDRGITIFSPDGRLYQVEYAREAVKRGTASIGVRTSDGVVLAVDKRVPSPLLEDSSVEKIHKADDHIGIASAGHVADARQLIDFARRQTQVNQLRYGEPIGVETLTKEVTDHIQQYTQVGGARPFGVALIVGGIDNGEPRLFETDPSGTPYEWKALAVGADRGELQEFLEENYDGDADLEGGIALALDALASVNDGSLLPSEVGLATVDVESESFEQFEQDRIGDHLEENGLLDDGEEEDEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSX7</accession>
    <name>A0A3N6LSX7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type I site-specific deoxyribonuclease</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_02440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HsdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93083">
        <property type="protein sequence ID" value="RQG93083"/>
        <property type="gene ID" value="EA462_02440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021810">
        <property type="entry name" value="T1RH-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11867">
        <property type="entry name" value="DUF3387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="280"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG93083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="996" mass="113585" checksum="CA6A4357989ED840" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT46</accession>
    <name>A0A3N6LT46_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">alaS</name>
        <name evidence="14" type="ORF">EA462_03090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93198">
        <property type="protein sequence ID" value="RQG93198"/>
        <property type="gene ID" value="EA462_03090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_A">
        <property type="entry name" value="Ala_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022429">
        <property type="entry name" value="Ala-tRNA_lgiase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03683">
        <property type="entry name" value="A-tRNA_syn_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="13">
        <location>
            <begin position="60"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="718"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="722"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RQG93198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="924" mass="102274" checksum="B71CBC2AED6419DF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT76</accession>
    <name>A0A3N6LT76_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2073 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_03245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93223">
        <property type="protein sequence ID" value="RQG93223"/>
        <property type="gene ID" value="EA462_03245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012017">
        <property type="entry name" value="UCP004977"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09846">
        <property type="entry name" value="DUF2073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004977">
        <property type="entry name" value="UCP004977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="133" mass="14559" checksum="3CA104F4C53B1344" modified="2019-02-13" version="1">MPKATNADDSNPSDGVQIDLISGERMDSMATMEKIRMILDGVHDGNIVILEEGLTPDEESRLIETTMAEINPDEFNGIEIETYPKSDTRDSSLLGRLMGAEESEAKLTVIGPANQIETLHKDETLISALVSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LUR8</accession>
    <name>A0A3N6LUR8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91324">
        <property type="protein sequence ID" value="RQG91324"/>
        <property type="gene ID" value="EA462_04905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="315"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="402" mass="43362" checksum="763AE4BB1839438B" modified="2019-02-13" version="1">MDPLEGEASSTSVEYEPISVKDVLIEMKDTAELLIDLSYSAVLHRNEDLAREVLRLEERMNVLELKARMSLLMAARNPDDAERLAPVLGIVAATDDISDAAGDIAKVVLEEMGLPEAMRAALPEATETLVRGVVDPDSPYAGRTLADIDLESETGVRVIALRRGDDWLLNPGPDTVIATDDVALLRGPDTVIGDVFETLTGTAHEFPSVDSPGIPDLERAVDTIVHMKNLSELAVDLAYSSILFDSAALAEEVRNLEVEVDAMQSRFEAWTLRAAADAEDPVVLRGLIRLGTSTEVISDAAIDISEGVLRDFDVHPVVQLAVQESDEIITRVEIEAGSDLDGTTVAAGVPDTESTMSVIAIRRPEEGWILVADSNTELRAGDVLISKGTRTAAERFEALSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LVI3</accession>
    <name>A0A3N6LVI3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_05535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91714">
        <property type="protein sequence ID" value="RQG91714"/>
        <property type="gene ID" value="EA462_05535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="555" mass="60448" checksum="22C5DDA2A4679144" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LY68</accession>
    <name>A0A3N6LY68_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4442 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87051">
        <property type="protein sequence ID" value="RQG87051"/>
        <property type="gene ID" value="EA462_15550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="157" mass="17800" checksum="6E331630BEFC72A9" modified="2019-02-13" version="1">MLASLRARLSRLAFNLFPAYRGTGGRVTYVAPDWREVRVKLPLNWRTRNYVGTTFGGSMYAALDPFYVMMLLKNLGDGYVVWDKEAEIRFKRPGRQTLYARFTITGEEIAAIRAELERDGTESVDRHYTVDLVDADGVVHATVRKTVYVATDESKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LYU5</accession>
    <name>A0A3N6LYU5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87863">
        <property type="protein sequence ID" value="RQG87863"/>
        <property type="gene ID" value="EA462_13450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="344" mass="38759" checksum="9F663E2DFBE6FCDD" modified="2019-02-13" version="1">MGDHMTRGEYDRLFTALVTPFKQGSYDVDESATRDLVEYYTENETFDSLGGGFIVNPEAGEVFYLDREERQRNVELVAEEASDEYPVFAGVFGVSREEIRTTAQDALEAGADGLFVMPPAGTMEVTTTLDARNNPEVWQNHVETVADVADVPVLVHPTAPMSHEYGEGLPLESTKAVVESEPNVVGWKMTYNFRGYEKIASYLRSLDRHVAVLGAEGSHFHAAQATGTFDGTVTGAWNFAMEPMLEHVSAWRENDVERARRIWHERLSDLFGYVYETFSRLHIRYKLATWLRGLTSHPFMRPPMPAPNEDEVDELDRLLRDAGLETIDEDRQEETKRTIAAGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ19</accession>
    <name>A0A3N6LZ19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87963">
        <property type="protein sequence ID" value="RQG87963"/>
        <property type="gene ID" value="EA462_13980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="593" mass="67043" checksum="14409F7DCA743CA4" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ20</accession>
    <name>A0A3N6LZ20_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87002">
        <property type="protein sequence ID" value="RQG87002"/>
        <property type="gene ID" value="EA462_15265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016427">
        <property type="entry name" value="UCP004699_CBS/ParB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004699">
        <property type="entry name" value="UCP004699_CBS_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="268" mass="29568" checksum="E2CD9A016B3B8802" modified="2019-02-13" version="1">MDVASDRRKPQVEEYMTRDVATVSPDTTVGSVAKRIAESDKHSGFPVCDRRRVEGFVSARDLLLASNDEPIFKVMTTDLLVAHPDMKVNDAARVILRSGIQKLPVVDDAGNLVGIISNADVIRSQIERATPEKVGKLKRTLEQIHEIELGEERRTVPLSELTPTQGKVYADELEGRRYELDRGLAEPLVVIDNGGTLLLADGHHRVLAADRLGIDEMDAYVIVIAGEIELGMAKTAAKEELEGISDIDVVDYARHPLVQTTKRLQSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ33</accession>
    <name>A0A3N6LZ33_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">YeeE/YedE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_14085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87983">
        <property type="protein sequence ID" value="RQG87983"/>
        <property type="gene ID" value="EA462_14085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="7">
        <location>
            <begin position="19"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG87983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="185" mass="19209" checksum="DDD38686C041B2D2" modified="2019-02-13" version="1">MATELIDPALYETLFPVGISRYAVGGVLVGLGAVVIYLGTAIPAGASTFLESTLSYVSDQSRFERYRRSRDWRVVFTLGIVAGAAVYALTFQSGLISSGLYQSGTTGELREVGGLTIWLTDVQPWRLFLGGVLVGIGTRIGKGCTSGHGVCGVGSASKTSIVGVITFLVVAIGTAQVVMALGVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZ88</accession>
    <name>A0A3N6LZ88_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Na+/H+ antiporter subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_15735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87082">
        <property type="protein sequence ID" value="RQG87082"/>
        <property type="gene ID" value="EA462_15735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="116" mass="12247" checksum="423E32135AA24E6F" modified="2019-02-13" version="1">MIESIRFWAIVVLVVAGLFFTFVSAVGVIRLPDIYARAHTASQTDTLGAGLALAAVAIALGWQHATVYTVLLLFFVFITNPTAAHAIARSAAETGIEPVTGDSSPEEDPDEEGETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M259</accession>
    <name>A0A3N6M259_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-succinylbenzoate--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_07650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89880">
        <property type="protein sequence ID" value="RQG89880"/>
        <property type="gene ID" value="EA462_07650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="432"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="536" mass="57172" checksum="7C93CC73D6E223EB" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M368</accession>
    <name>A0A3N6M368_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_10000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90300">
        <property type="protein sequence ID" value="RQG90300"/>
        <property type="gene ID" value="EA462_10000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="216"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="291"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="747" mass="82910" checksum="1A186F4725DDF927" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M386</accession>
    <name>A0A3N6M386_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_16915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000008">
        <property type="protein sequence ID" value="RQG86153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86153">
        <property type="protein sequence ID" value="RQG86153"/>
        <property type="gene ID" value="EA462_16915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006469">
        <property type="entry name" value="NifC_ABC_porter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01581">
        <property type="entry name" value="Mo_ABC_porter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="61"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="272" mass="28212" checksum="D46EBF7980C87D4D" modified="2019-02-13" version="1">MSLSAESASGRSRRTPELLVPALLGGVILAYFALPFLTFLSRTGTANVVSGLTTPNAQVAIRNSLITAPLSTTIATVFGVPLAYVLARRSFVGKRLVEALVILPLVVPPVVGGAMVLTAVGRFTPIGSAAAAVGISLTDSLVGVVLAQTFVAAPFVIITARAGFGAVDERLERASRSLGYGPLATFWNVSLPLARGSIVAGITLTFVRAIGEFGATMMVAYNPRTMPTRIWVDFIAGGIDAIVPLGVALLAITLAVLAAVQRFGRVPTVIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M495</accession>
    <name>A0A3N6M495_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L31e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl31e</name>
        <name evidence="6" type="ORF">EA462_15105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ribosomal protein L31e family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86977">
        <property type="protein sequence ID" value="RQG86977"/>
        <property type="gene ID" value="EA462_15105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00410">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_L31e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_L31e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_L31e_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="PTHR10956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="SSF54575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG86977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="92" mass="10441" checksum="E41C6874D94775AB" modified="2019-02-13" version="1">MSASDFEERVVTVPLRDVKKGPNHEAADYAMRLVREHLAKHFAVDEDAIRLDPSINEEVWSQGRSNPPRKLRVRAARFDEEGEAVVEAEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4I2</accession>
    <name>A0A3N6M4I2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dCTP deaminase</fullName>
            <ecNumber evidence="2">3.5.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Deoxycytidine triphosphate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dcd</name>
        <name evidence="5" type="ORF">EA462_09125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the deamination of dCTP to dUTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dCTP + H(+) + H2O = dUTP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="EC" id="3.5.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.13" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90141">
        <property type="protein sequence ID" value="RQG90141"/>
        <property type="gene ID" value="EA462_09125"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="73"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="105"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="200" mass="22067" checksum="91741E9E9EE1C862" modified="2019-02-13" version="1">MILSDADILDRLDNGDLVVDPLDDLELQIQPASVDLRLGREFLEFQRTNIPCIHPNSEREVDEYVTETVVENGDDFILHPGDFVLGTTHERVEIPADLIAHVEGRSSLGRLAVVVHATAGLCDPGYRGQITLELSNLGSAPVALTPGMRISQLTFTELRTPAERPYGSDRGSKYQDQDGPQASRIQSDDEFGGDQLERDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4S7</accession>
    <name>A0A3N6M4S7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90241">
        <property type="protein sequence ID" value="RQG90241"/>
        <property type="gene ID" value="EA462_09670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="325" mass="36162" checksum="473E84F8F1C54E81" modified="2019-02-13" version="1">MTDKARSTSRRKLLATTGSLAALGIAGCLGDDDGSDGNGGDDHDDDHDHDDDHDDHDHDDDHDDHDHDDDHDHDLAVAEFEVLDRNHDEDVLVYVHGTHWHQDPLEVPHDDTLSLGAYVEDEDGNEVELGDGIEFTGAVVDDATELVEVESHGDHVHVHGNEDGFTDIVFQLIEDGDVVYETPELETEVGHHDHDDHDHGEVDELSILDRAEDPHEEVATFHDGHWDGEVPHVHVDDNVSLGAEFLDDHDDEIPIGSSEEYELAVMLADDAEEGVVEIDPDDHWHGDHVHIYGKSEGETDVVFALWHDDHADWESEPIAVSVEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M4V0</accession>
    <name>A0A3N6M4V0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90271">
        <property type="protein sequence ID" value="RQG90271"/>
        <property type="gene ID" value="EA462_09845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043854">
        <property type="entry name" value="DUF5816"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19133">
        <property type="entry name" value="DUF5816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="249" mass="27732" checksum="1FE45EC108A8165C" modified="2019-02-13" version="1">MEIREATDSDVDTIRSLAHRSLGSTYTDFLDEETVDDAIEEWYGDSFASELEDDGSLVLVVERDGDIVGFSQSDLIGQQHRTGRLLWLHIDPETRGGGIGVRLLVRTRERLLGEGAEGIQCFVLEDNEGGNEFYRSNGFERAGQREVEIGAETFTENVYAEGELEDDGWGAVDELEVDGEVVYVSYGEAARGSKAPFYTAYGSPDRAERYAWLCGNCDSLDNAMDSMGRIECNVCGNRRKATRWDSSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M516</accession>
    <name>A0A3N6M516_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">XdhC/CoxI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_03630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91100">
        <property type="protein sequence ID" value="RQG91100"/>
        <property type="gene ID" value="EA462_03630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="2">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="3">
        <location>
            <begin position="238"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="417" mass="45043" checksum="1A6171F83DA8532E" modified="2019-02-13" version="1">MTESQKTQTQRNWSVPETEVVQRVHQRLEADGSDVLATIVDVDGNAYRRPGAKMLLDDAGDGVGSITAGCLEDDILRAAESVRGTGQPELVTYDLMDDDDDVWGLGVGCNGIIEVLLEPLTPSYRSATDAFTEGRDVAVLTVLSVHGEDVDASDTDSPLAYGDRAYYHPGEDRLSTPSDDDGASGDGGETTEADWPIDVLSEPASELAGRGRANVIDLEVDGTRLEVFVDGIAAPAELVVFGSGHDVGPVTELASKNDFRVTVVGFRGAVDLAERFPDADRTVTTSPGTIEDDLEMGLDDRTYAVVMTHNFVDDRLAVETLLDAGVPYVGLMGPHERFEEMIEEFDAEERTITDDDRSSLYTPIGLDLGGGSPYQIAHSIVAEVLAVHNDRDPRHLRAREGHIHDRIEVEADPTPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M542</accession>
    <name>A0A3N6M542_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87809">
        <property type="protein sequence ID" value="RQG87809"/>
        <property type="gene ID" value="EA462_13125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="271"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="572" mass="64585" checksum="2C89C382ED9C81CA" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M546</accession>
    <name>A0A3N6M546_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91130">
        <property type="protein sequence ID" value="RQG91130"/>
        <property type="gene ID" value="EA462_03800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="2">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="109" mass="12164" checksum="B7DF905571E7543F" modified="2019-02-13" version="1">MGSLLTQHDHRPVHRAHFDPLSSNQLSSTIIEAISTVEDESPLELTPLYETIDLEALEQLLTHSVSAESSDDFVVEFSVDNWDVTVIGDGQVLIHDNPTDSETAREHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M550</accession>
    <name>A0A3N6M550_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Methionine aminopeptidase</fullName>
            <shortName evidence="3">MAP</shortName>
            <shortName evidence="3">MetAP</shortName>
            <ecNumber evidence="3 4">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">map</name>
        <name evidence="6" type="ORF">EA462_03855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3 4">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="3 4"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91140">
        <property type="protein sequence ID" value="RQG91140"/>
        <property type="gene ID" value="EA462_03855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01975">
        <property type="entry name" value="MetAP_2_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028595">
        <property type="entry name" value="MetAP_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="14"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="298" mass="32829" checksum="32F57091DBF0D112" modified="2019-02-13" version="1">MSEHEVDLESEQYEKHREAGEILSQVRRETADRVEVGASHLEIAEYAEDRIRELGGKPAFPVNISIDEEAAHATPKVDDDATFGEEMINLDIGVHIDGWLADTAITVDLSGNPELAEASEQALEAAIDVIEPGVETGEIGAEIEDVIDGYGYNPVVNLTGHGLDHWEQHTTPNIPNRAVTQGTTLEVGDVVAIEPFATDGGGKVTEGASEEIFALEREGNVRNRQARDALDQITEEFRTLPFATRWLETDRPEMALRRLKRSDIVHGYPVLKEDDGRLVSQKEHTIIITESGCEVTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M5F6</accession>
    <name>A0A3N6M5F6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87959">
        <property type="protein sequence ID" value="RQG87959"/>
        <property type="gene ID" value="EA462_13940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009359">
        <property type="entry name" value="PaaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038693">
        <property type="entry name" value="PaaB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06243">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="90" mass="9933" checksum="E61E2FB0A360B5BB" modified="2019-02-13" version="1">MKGKRTYEVLARINAGEPLQSIGSVDASSDEFAKQYAEMFYDEEDWEVLFVVDRKDILKVSGDPGHEYKDVGGEIDDGAVGFVKRAGGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6A7</accession>
    <name>A0A3N6M6A7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="11" type="ORF">EA462_06455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91590">
        <property type="protein sequence ID" value="RQG91590"/>
        <property type="gene ID" value="EA462_06455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="10">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="143"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="237"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RQG91590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="325" mass="36330" checksum="F2D00BE804EB9402" modified="2019-02-13" version="1">MTDSTIRTHSDERRETEREESLEEADERERCPECGGRVISDDEHGETVCVECGLVVDEDEIDRGPEWRAFDSAEKDSKSRVGAPTTNMMHDQGLSTNIGWQDKDAYGKSLSSRQRQKMQRLRTWNERFRTRDSKERNLKQALGEIDRMASALGLPENVRETASVIYRRALEEDLLPGRSIEGVATSSLYAAARQAGTPRSLDEISAVSRVEKDEIARTYRYVIRELGLEVKPADPESYVPRFASDLELSDETERRARTLLKTAKEEGIHSGKSPVGLAAAAVYAAALLTNEKVTQNEVSDVASISEVTIRNRYHELLEAEGGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6G4</accession>
    <name>A0A3N6M6G4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">EA462_10900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88896">
        <property type="protein sequence ID" value="RQG88896"/>
        <property type="gene ID" value="EA462_10900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RQG88896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="641" mass="69422" checksum="271261F69C4F110B" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6I7</accession>
    <name>A0A3N6M6I7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88926">
        <property type="protein sequence ID" value="RQG88926"/>
        <property type="gene ID" value="EA462_11060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG88926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="151" mass="16345" checksum="F3D5744526B98D76" modified="2019-02-13" version="1">MTWLRALAAAGLSVLLPGAGHALIRDWLRTLVFAGLYLTAAVLFLPSPEQIAAAGSITDSMELVTQEIDTMGQFILSFIVLFAAIDATFRSLGFPPGSNSKAADGPTCPHCGKELDQDLSFCHWCTTRLEPQDPEEPTDAEQDERPIRANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M6W5</accession>
    <name>A0A3N6M6W5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0146 protein EA462_11910</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_11910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0146 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89076">
        <property type="protein sequence ID" value="RQG89076"/>
        <property type="gene ID" value="EA462_11910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00341">
        <property type="entry name" value="UPF0146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005353">
        <property type="entry name" value="UPF0146"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03686">
        <property type="entry name" value="UPF0146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="139" mass="15192" checksum="C709AEBA79CB91D8" modified="2019-02-13" version="1">MSHSRRNDRTLLDFLLEYDRVVEIGIGRRTELAAALADRGVSVTATDVHRREAPDGVRFVRDDIVDPDPAVYANADAIYARNLPPELHRPALEVARIAGAAFAFTTLGGDQPAVPVERRTIREGTLYVARTPAGDVDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M713</accession>
    <name>A0A3N6M713_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Divalent metal cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_03755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91121">
        <property type="protein sequence ID" value="RQG91121"/>
        <property type="gene ID" value="EA462_03755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="456" mass="46639" checksum="34FB80FD1A22F6D9" modified="2019-02-13" version="1">MTTETTTDGVTVGRVGTFLRRLGPTWLAGAIAAGPATMVSLLVAGASFGYTLLWVVVLSAVLGTIGQYLAMRLGLLTEAGIVTVVEEHLGSFWAWVLVVDVVLAAGLAQLVIMKTLAEISATIVGGSVLGFAALGDPRLWGITWAIVLALGLAGGGYRLAEIGAKVLVSLVVVAFVVSAFVVPIDPGAAASGLVPSMPAGVGGAVVAAGVLGGAVHITLLTMQSYTMRARGWSRDDGDIATFDVVSSMLVAFGVFSLAVFLVAASVLPEAGIDPATIDEIQAAAALGPVAGEYAVWLFLLGLLGAAVSTLGGNTIVPPYLIADKLGWDRSIEDGRYRAAIVTVALASALGAFLEGAFFQLLVLVLAFGLVGTPFALAVILVLLNDREVVPETNSHLANVGGIALFVVATVLAGEFVLDELETVTEPVSAFVVAFAAAMALAIVGLGVTFLRKRIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M7F3</accession>
    <name>A0A3N6M7F3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Death domain-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_04585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91271">
        <property type="protein sequence ID" value="RQG91271"/>
        <property type="gene ID" value="EA462_04585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043902">
        <property type="entry name" value="DUF5786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19099">
        <property type="entry name" value="DUF5786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5786" evidence="2">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG91271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="60" mass="6670" checksum="84498B12925BEBDD" modified="2019-02-13" version="1">MGFGSYDESEQNQQTASDEDDVEAVNVHENDHDGQLSFESDLSTDELVSQLGSMKDDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M815</accession>
    <name>A0A3N6M815_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_05940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91501">
        <property type="protein sequence ID" value="RQG91501"/>
        <property type="gene ID" value="EA462_05940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="110"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="253" mass="27783" checksum="7367AECE3FD2F3ED" modified="2019-02-13" version="1">MTRRPRSKSESTSGDRSERGILRALGRLVVLVLLVSAVVLGAATFATTLIERAEDADGIDLQDRPDPSSNPPPAGERDPDVTDPDDPGVSSYETDVETVRSDAVEDFVHAAVNDRRADHGLESLEWDGTVASVSRAHSYDMAHRDYFSHGNPDGEGPYDRFSEVDDYCRGYGENIALTWIDRPIERPGNGDTVEYYTAEDLATGLVDQWMNSTSHREAILEEHGGPGWDRGGVGVYIADDGAVYASHNFCHEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8U5</accession>
    <name>A0A3N6M8U5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase subunit Rpo5</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">DNA-directed RNA polymerase subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpo5</name>
        <name evidence="2" type="synonym">rpoH</name>
        <name evidence="4" type="ORF">EA462_00065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92670">
        <property type="protein sequence ID" value="RQG92670"/>
        <property type="gene ID" value="EA462_00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="SSF55287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb5_C" evidence="3">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG92670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="75" mass="8475" checksum="6DE06A73A23628E7" modified="2019-02-13" version="1">MVDVSQHELVPEHTVLEEDVLEGVLTEYDIDRTDLPKIKRTDSALPDDAEAGDVIKIVRNSRTTDQAIVYRLVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M933</accession>
    <name>A0A3N6M933_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-alcohol phosphatidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_08290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89996">
        <property type="protein sequence ID" value="RQG89996"/>
        <property type="gene ID" value="EA462_08290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG89996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="203" mass="21616" checksum="1A1025A1E2849017" modified="2019-02-13" version="1">MTLDQLRPYVSRFLDPFVEGFDRIGMTPDGVSVLAFGMAILAAVAFVLGGRADPIWYVGAAALVFLNGWLDVIDGALAREQDVASAGGDLLDHVLDRYADIVIIGGLAAGVESYFLGFLAVTGVVMTSYLGTQAQAVGLERVYGGLVGRADRLAIIGFVGFLAYPIEGTYGGLTLVGWLLVFLAVVGHLTALQRFFYSWTALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9E0</accession>
    <name>A0A3N6M9E0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S3Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosomal protein S1e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps3ae</name>
        <name evidence="5" type="ORF">EA462_09100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90136">
        <property type="protein sequence ID" value="RQG90136"/>
        <property type="gene ID" value="EA462_09100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00359">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030838">
        <property type="entry name" value="30S_S3Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_S3Ae"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG90136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="213" mass="24102" checksum="7DFBC2466CE3FDB7" modified="2019-02-13" version="1">MSERSVSRAKQEKRWYTVLAPEQFDRQELGETPADEPEKVYDRTVETTLGELTNNASENNTKLTFKVTDVGSDSAYTEFKEHSLTRDYLRSLVRRGASKVEAYVTVLTTDDYRVQIQPVAFTTKKADASQEKAIRETMVEMVESAAEERTFEELISSIVEGRLSSAIYGEAKTIYPLRRVEIQKSTLEAHPDEVAEEEATSVNVDEEDVATDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MBQ6</accession>
    <name>A0A3N6MBQ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_03605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91096">
        <property type="protein sequence ID" value="RQG91096"/>
        <property type="gene ID" value="EA462_03605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="113" mass="11916" checksum="93D383C18DB2A46C" modified="2019-02-13" version="1">MASQNQAETDQQTTEPGPKSDAAAADSVPAAVEIDVPDDASDEEAAAIAAAMGAHLHDHALAVAAAAADDDQEWDGKRWAFSGRIRTQQGRTVRVPRHAPTNPWSAAGRTDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MC01</accession>
    <name>A0A3N6MC01_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I-D CRISPR-associated protein Cas7/Csc2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cas7d</name>
        <name evidence="1" type="ORF">EA462_02020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93011">
        <property type="protein sequence ID" value="RQG93011"/>
        <property type="gene ID" value="EA462_02020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017574">
        <property type="entry name" value="CRISPR-assoc_prot_Csc2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18320">
        <property type="entry name" value="Csc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03157">
        <property type="entry name" value="cas_Csc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="329" mass="35615" checksum="B7BE19892DF4EACB" modified="2019-02-13" version="1">MLPESITTALESGTVPIDEMTNTPGTNYTTILALRELESHAIFTTNGEDADIASLSVVGEDASIEYSPGIMFMRKQTGSDRRMGKAIQRELLDYEEDDSMEVNNMNPRSVESALYGSAASGDDDVDIGVTSRVMYDTAFSVRDASACIDEKFQNAPGEDYAKGSRSTIREPDFFEPGSLFPCAITLRDATPAEVAFVVAITKRNKRYGAATTRLGRVKNHILGVYTGSEEGPSNRELTANVITSFAADSDYTLGDVVQAPALDISEASEYVRDAYDAACTEEVAQNPVDQAVVNELIEVAADDELEAILEAQRPHSEEFIEDAIATDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MCN2</accession>
    <name>A0A3N6MCN2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_03455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93261">
        <property type="protein sequence ID" value="RQG93261"/>
        <property type="gene ID" value="EA462_03455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="351"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG93261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="551" mass="61322" checksum="EB47436E17C30687" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MD05</accession>
    <name>A0A3N6MD05_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Probable thymidylate kinase</fullName>
            <ecNumber evidence="2 4">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tmk</name>
        <name evidence="6" type="ORF">EA462_06825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2 4"/>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91656">
        <property type="protein sequence ID" value="RQG91656"/>
        <property type="gene ID" value="EA462_06825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="5">
        <location>
            <begin position="5"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG91656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="203" mass="23138" checksum="179C38CF49850AD0" modified="2019-02-13" version="1">MLVTLEGLDGSGKTTVWESLQEVHPEATFTREPTDSWYGDAVYRSIEDDDADPLAELFLYTADHADHLSRLVEPALARGDHVVSDRYSDSRFAYQGATLEAWAERTTERGLEDPLEYVVDVHEPISIEPDLTIYLDLDAETAAERAGTTNKFERADYLESVRENYERLIERDPDRFVRIDATRSPEAVLERTIDVLETRGVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MFL4</accession>
    <name>A0A3N6MFL4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92696">
        <property type="protein sequence ID" value="RQG92696"/>
        <property type="gene ID" value="EA462_00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="217" mass="23774" checksum="47D03B0626BB99C0" modified="2019-02-13" version="1">MGTNYDAVVFDNDGVLTTPTDRDVLLAAIASAFDDVGVADPPREHVETLLGPTLSELRRIAAGHEVDPATLWTARERAAVEAQLEEILTGRKRRYDDVEAVDSIDVPTAIVSNNQHRTIANILEHCELDGFEVWYGREPTLEGIERKKPAPYYLERAIDDLGATDPLYVGDSPVDVVASEAAGVDVAFVRRDHRLAADPPTEPQHDIDSLTALPELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRL2</accession>
    <name>A0A3N6MRL2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_14685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86903">
        <property type="protein sequence ID" value="RQG86903"/>
        <property type="gene ID" value="EA462_14685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG86903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="230" mass="25953" checksum="DEC3E31AE8DAE6F9" modified="2019-02-13" version="1">MKSVRLTLQHGPENVHPMHRFVADHDAFSRYRMVTWNHAHDGYNVFLFHVVGDREVYQKRLRKLESPITIDVTDGKTAATNRDGERGSADGGSFYVYVREEPGQLDEQLVSAFAHGSLIPIPPLEYRMDWSVRFGLVGESEDIQSALEAVPDGIETTVERVGEYRGGDRALETVTERQREALRIARELGYFAVPREASVEEVAAELDCAPGTAAEHLRKAQQRVMGRLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MSQ4</accession>
    <name>A0A3N6MSQ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase/muconate lactonizing enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_12995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87785">
        <property type="protein sequence ID" value="RQG87785"/>
        <property type="gene ID" value="EA462_12995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="170"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="410" mass="45447" checksum="A50DB0B7DC166339" modified="2019-02-13" version="1">MYEDFASDLAVTMWAEFDQTPTRNESTPEITDLNTIVVDGNFPWTIVTVETDEGVTGIGEAYPSPGVHEVITDYLRPVLVGENPLDVERLYYLMRGSLSGRGSQWGIGTIAISGVEIALWDAVGKILEQPVYQLLGGKMREEVQVYADCHAGEAMVSSAQEGQEAETYQPEAYAEAARMAVDDGFDMIKFDLDVPSGRDVNTLSRHFDGVEIEHKRSIVEAVTDEIGGDAEVAVDLHWNFSPETAERLCRAIEPYDLAWIEDPLPPENTDAMRELKRRVDVPLLTGENRYGRHGFRDLIEGQGVDFLAPDVPKVGGIAETKKIADMAETYYQALIPHNIGSPVATVATAHVGATVPNFVALEYHAREVPWWEDLVARDEPLIRNGRLEVPDAPGLGIELDWDVVEEHRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MT72</accession>
    <name>A0A3N6MT72_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0033 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_14095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87985">
        <property type="protein sequence ID" value="RQG87985"/>
        <property type="gene ID" value="EA462_14095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="1">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="81" mass="8737" checksum="A3AE00301C77C2E8" modified="2019-02-13" version="1">MSSEYQITETLDVKGQSCPMPIVKTKQAIDDLEAGDVLEVVATDSGSMSDIRGWAKGTDGASLLEQVEGDDVYIHYVKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MX29</accession>
    <name>A0A3N6MX29_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90042">
        <property type="protein sequence ID" value="RQG90042"/>
        <property type="gene ID" value="EA462_08560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="175" mass="19800" checksum="49864D24C56B84F1" modified="2019-02-13" version="1">MSQFTCQAHLDEYVIDDDDLGTFGMDNSTITYTTDDEESSISVPISEINDVTFDRDTTLHRFRFLGFFFGILTLVLVAFAYLLAFADPDPGPDQNVIVIFTIFLIIGGVATTRNFFRHENHDVIDICIKTDDDLYTVCGRMGNTNFVEACAKLIESDIPTMNRNSRLESVLDREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MX97</accession>
    <name>A0A3N6MX97_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_09020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90122">
        <property type="protein sequence ID" value="RQG90122"/>
        <property type="gene ID" value="EA462_09020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="44" mass="4551" checksum="BD2D789806C63110" modified="2019-02-13" version="1">MVRLSTVVILAGVVLLFVPIPPIATISGILVILVGIALRLLKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXM0</accession>
    <name>A0A3N6MXM0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_09795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90262">
        <property type="protein sequence ID" value="RQG90262"/>
        <property type="gene ID" value="EA462_09795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="21"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="366" mass="40026" checksum="5AE897147489EDEE" modified="2019-02-13" version="1">MEYETPLFFRVIEYASRADRDVIDMVSGKPDWEPPSAVRDGLSEYATHPSDAFQYPPSEGLFELREEIARRRGVDTEHVVVTNGAAEANYLAMACALERDRGDEILLTDPVYPYYPGKTTMLGGTQSFVPTDATGQLDPAAVRAAASDETAAIVVNSPNNPTGAVYPAETIHSLVAIAEEYDAILISDEVYDRYDLSGEFESALAAKSNHRVVTNAFSKSMAITGFRVGYAIFPPKLAASAKSRHMLVNVTASRPAQYAALNALRETDPEYYDGNRALLRERVETFTDALEAAGASYTTPMGSFYVMARFEEYPGTLENVFRLIDEAGVAGMPGEAFGDSRAAWVRFALVTPRVEAAAERLAAFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0B3</accession>
    <name>A0A3N6N0B3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91322">
        <property type="protein sequence ID" value="RQG91322"/>
        <property type="gene ID" value="EA462_04890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="163"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="338" mass="39230" checksum="96FF313BE291BB65" modified="2019-02-13" version="1">MGHDVRHVESIEAVNRNQWNNVVDQSDLSCVTHRYEWLRAIESGLEYEPRHLIVSKGGNPIAVFPNFVTELGRINRLSSIRPGYGGPVTMTDEETALELLLDSVGELCTGRILFNEIRTYDQNYVRYHDLLEQRGYRPTILSCRFTLDLSRGWDDLFEGMDGKRRRGIRRGHDYDFDVVEEELTERTLSVFYTDYAAVADRVGLPKQPRSFFGELRAFDERIALFSLRVDGERQGMYMYLLDDEQSALQHLFTAVTEDHFEYHAPELLHEHAIRWGIEEGYETYELRGSPPDFRNGVFRFKEYFGAETIPLLVYERGYPSPALPVLNAGRTLSRRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0R7</accession>
    <name>A0A3N6N0R7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDPG_MGDP_dh_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91512">
        <property type="protein sequence ID" value="RQG91512"/>
        <property type="gene ID" value="EA462_06000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="91" mass="10143" checksum="BA5F8DE010787D7D" modified="2019-02-13" version="1">MPFEANAFIIAVPTDMNGDEPDMSAVRIARRTVAKYVPDRGILCVCSSTVYPDAADEIVRTSFERRSYVVGRFVAIDRHQYGEGRSACCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N108</accession>
    <name>A0A3N6N108_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HalOD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91622">
        <property type="protein sequence ID" value="RQG91622"/>
        <property type="gene ID" value="EA462_06640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040624">
        <property type="entry name" value="HalOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18545">
        <property type="entry name" value="HalOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HalOD1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="89" mass="9789" checksum="2AE75666C8E83B51" modified="2019-02-13" version="1">MGHGESISVTITRAVAAYDGVRPTELDPPLYDAIDTDALNALFRPSDNATDNRSISLEFRYEDYTIRVAGPDDIEIELANATPESTETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N3U0</accession>
    <name>A0A3N6N3U0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome C oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_00865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92812">
        <property type="protein sequence ID" value="RQG92812"/>
        <property type="gene ID" value="EA462_00865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13913">
        <property type="entry name" value="ba3_CcO_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034214">
        <property type="entry name" value="Ba3_CcO_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="5">
        <location>
            <begin position="65"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG92812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="280" mass="30516" checksum="82A0A047934A78EC" modified="2019-02-13" version="1">MNIHTYEKLWLIAAMLLIVGFIATITYGSVGLGIAMVGDQQETVEPTQLGEDDRFAEPRVEHVGENQYEAYVIAQTFRFQPDPIEVPANSEVTFHVTSRDVIHSFSVAGTNINTMVIPGEVAEMTVEFDDPEEYGIVCNEYCGPDHHNMEGQLHVVPEDEFDLTELSVDASDEIGPDEEAAFEISVENRMLEDRDTAVSLEIGEEMQTEEVTIGGEETHVTTFTVDGATLGEGDHSWTVSADGHEESGSITVTDGESDEDGADDGESDEDGTDDGGESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N410</accession>
    <name>A0A3N6N410_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92902">
        <property type="protein sequence ID" value="RQG92902"/>
        <property type="gene ID" value="EA462_01385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="118" mass="13291" checksum="664BC33A89F8A561" modified="2019-02-13" version="1">MDADAPPEWTVDECRSYTPADVDRELQYRTYIHESGDLRVKVAPAALDGDDRPGYSLTVTSYPGLELSETNRIRTVLTADRCDQIARRFMTLFAASYDGPGSLEDALEYAATRTRDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NUZ4</accession>
    <name>A0A3N6NUZ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87060">
        <property type="protein sequence ID" value="RQG87060"/>
        <property type="gene ID" value="EA462_15620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="400" mass="44750" checksum="15E5A09DEAE32448" modified="2019-02-13" version="1">MRRRGFCTLSTLGLLGGCLQLQEQSTGETDDGTETSPDGEDGDTRTETDGIERDTERIDLVEAWSRDVDSIAFHDGSFVGVVRPPHSDEVETTRLERYDEHGEIDWSSDEIEDGYRFAITEHDGGGIRSLDGAIVTAATGMEDTDGARLYAFDSETGEQLWVHETDGERAETYFRALTVHDETIYYGVTDSGGTDEDQNPSIRAIDTTTGDVRWEEQFDEGFFSGITVFDDRLYVGRGWELNVFERETGTRVHEEDVSIGFDGFIVTEDTLYFAESELQAYDPVDDELRWEREPDRTFDSGITHTNGTIYGGTRSGWVLARDESDGDLLWETRIDGSVINPLLVDHGVLWTVSDSHELSALNADTGAILYERENGSRRIATGSGRVFIEETAYELERSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NV17</accession>
    <name>A0A3N6NV17_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_15850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87100">
        <property type="protein sequence ID" value="RQG87100"/>
        <property type="gene ID" value="EA462_15850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG87100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="365" mass="38536" checksum="F2E6899450F409C1" modified="2019-02-13" version="1">MNAAINPLQNSDTVLLPERIGDLTGLSEFGIAGELIAAFLGAFIIANLMLAMTGVAGPWAKRKITAAFTDRIAVNHIGPGGILIIVADAVRLLSKENIIPENADRPAYDLAPIVIAGSALLGFAVIPMGSGIHLADPEVGLAFVFAVAGIASIGLVMAGYASGNKYSMLGGLRAVAQNIAYEIPLVVTGMSVVLFAGSLQMGEIVAVQNETVLFTIPGLEWAVPAWFALVNPFAFVLFLIANFAEVGRNPFDMPEAPAELIAGYQTEYSSVYFVLVYLGEFLHIFLGGAIIATIFLGGPAGPGPSELGIVWFILKIWGVFFLTQWLRSAIPRVRIDQLIEIGWKGLLVLSFANLALTAAIVGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NVH9</accession>
    <name>A0A3N6NVH9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87842">
        <property type="protein sequence ID" value="RQG87842"/>
        <property type="gene ID" value="EA462_13320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="51"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="138" mass="15050" checksum="829185837A7FE5D9" modified="2019-02-13" version="1">MSNESYHLVTVDNIEAEPDRPDIEPEPDPTADAFSISAETGLEILGLRTYTAEPGEQLPLAYHYHETQEEAFYVLEGTLHVETPGKEYVVRPGHLFAAEGGSPHRAYVPEGATEPTRVLAIGAPSDDAGRVYDPNDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NYU5</accession>
    <name>A0A3N6NYU5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate dehydrogenase (Acetyl-transferring) E1 component subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pdhA</name>
        <name evidence="4" type="ORF">EA462_08595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90049">
        <property type="protein sequence ID" value="RQG90049"/>
        <property type="gene ID" value="EA462_08595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="3">
        <location>
            <begin position="47"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="375" mass="42367" checksum="F6B74A13D1114620" modified="2019-02-13" version="1">MTRDVLEYDLLEWEPDDCVRVLDADGTVVASELEPNLEDETLRSMYRDMRFSRRFDERMISLQRQGRMGTYASLAGQEGSQIGSTYALTGDDMISYQYREHGAVVARGLPWEYLLYWMGHEDGNAALADVSVFPLNISIGAHIPHAVGWSWAEKLNDDEAVTVVHFGEGSTSEGDFHEAMNIAGVFDTPTLFFCNNNQWAISMPQDRQTASDTFAQKASAYGFDGVQVDGMDPLATYVVTAAARAKALDSESENPRPTLIEAVQYRFGAHTTADDPSVYRDDDAVERWRERDPIDRFEAYLEDRGLLDADRIETIETEIDDTIEQLIERAESVDPDPQELFEHVYDDPTPRLEAQRESLAKLRSRHGDDELLEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZ11</accession>
    <name>A0A3N6NZ11_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="8">4.1.1.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mvaD</name>
        <name evidence="8" type="ORF">EA462_09055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="8"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90129">
        <property type="protein sequence ID" value="RQG90129"/>
        <property type="gene ID" value="EA462_09055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="93"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="MDD_C" evidence="7">
        <location>
            <begin position="192"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="327" mass="36136" checksum="05A837CD685A1E13" modified="2019-02-13" version="1">MKATAMAHPIQGLIKYHGMRDDIERLPYHDSISLCTAPSHTRTTVEFSMEYDEDTFVVDGEELDGRAYERVEAVVEKARSLSDAAHTVYPVRLESENSFPSNVGLGSSSSGFAAAAVALAEAAELDLSLSEISTIARVGSASAARSVTGAFSQLDSGLNDDDCRSRRLPTNLHEDLKIIVGLVPYHKETEDAHQEAAESHMFDARMAHVHDQLVEMRDALRADDFERAFDLAEKDSLSLTATTITGPSGWIYWQPATLKIFNRVRELREEEEIPVYFSTDTGATVYVNTTEDHAEYVEEEIADCGVSTTTWEVGGPARLLEDDDHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NZN0</accession>
    <name>A0A3N6NZN0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_15400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87026">
        <property type="protein sequence ID" value="RQG87026"/>
        <property type="gene ID" value="EA462_15400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="131" mass="14760" checksum="A70C69EAA2ADDA31" modified="2019-02-13" version="1">MPSHKANKHGTACEYHLAEKYRVDLVGEDGKRLDTSWYDGLKNGTPWEFKATAHKHADGNPGNFKVYKRYHGKLRREGGWYAFAVYRRRGTGTQVLKTEAVAASSLPTLRWHGGGDHRGTEQAKISISDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1L2</accession>
    <name>A0A3N6P1L2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88975">
        <property type="protein sequence ID" value="RQG88975"/>
        <property type="gene ID" value="EA462_11335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="71" mass="7640" checksum="F703829FDCEE1CC6" modified="2019-02-13" version="1">MHFGVATIARAATNRGFDVLVVDDATASFDRTYDGESVDAGTIHRTTLAQLDGEFATIITAAEILGEQRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1T0</accession>
    <name>A0A3N6P1T0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89065">
        <property type="protein sequence ID" value="RQG89065"/>
        <property type="gene ID" value="EA462_11850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG89065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="90" mass="9723" checksum="8D0E88EE43463C63" modified="2019-02-13" version="1">MEFNVIIAFLIGFIWGTIVFIYGKVSNADPIPRYDGTFRSAIRIGIDIAFVGGGTGTVVYLTESYLSAFQYGLAGIVFACIAVAVSVNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P237</accession>
    <name>A0A3N6P237_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_06680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91629">
        <property type="protein sequence ID" value="RQG91629"/>
        <property type="gene ID" value="EA462_06680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="651" mass="72935" checksum="92522B6C5B4393C7" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P3X9</accession>
    <name>A0A3N6P3X9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_08680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90065">
        <property type="protein sequence ID" value="RQG90065"/>
        <property type="gene ID" value="EA462_08680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="263" mass="28199" checksum="628C5F3711531DFB" modified="2019-02-13" version="1">MLPTSTGNAVIVAIDHGLSHGRLERFEDPEATLQTVLEGNPDGILAGIPFLRRFDSLLSEHPDLVTVGTVDQPVDSTLPGDRENAEIHHQAFSVEEAARVGVDAIKTALVFGREDPDVLANNLQLISEVSETARAYGIDSVVEPTLWGQRAEDELDAEYLAHANRIGFEIGADILKSPYTGDPESFAPIAEDAPVPMYIAGGPAQDDDAAVLEMVRSGMDAGIHGVMFGRTIWKHDDPAGMIAAIKSIVHEDASVQDAADHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4D1</accession>
    <name>A0A3N6P4D1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_09635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90235">
        <property type="protein sequence ID" value="RQG90235"/>
        <property type="gene ID" value="EA462_09635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG90235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="146" mass="16468" checksum="27ED10B08CED0821" modified="2019-02-13" version="1">MTDLVETLVENREMVQPNHANMLEVAHGGNVMKWMDEVGAMSAMRFAGETCVTVRVDRMDFERPIPVGDTAYITAYVYDAGTSSVRVRLVTEREDLRTREREKTTESYFVYVAIDDDNRPTSVPELTTGTKEGERLRTKALEGNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4L2</accession>
    <name>A0A3N6P4L2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor E</fullName>
            <shortName evidence="4">TFE</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">TFIIE subunit alpha homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription initiation factor TFIIE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">tfe</name>
        <name evidence="7" type="ORF">EA462_10195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The winged helix domain is involved in binding to DNA in the preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TFE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90335">
        <property type="protein sequence ID" value="RQG90335"/>
        <property type="gene ID" value="EA462_10195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01909">
        <property type="entry name" value="TFE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016481">
        <property type="entry name" value="TF_E_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="PTHR13097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006373">
        <property type="entry name" value="TF_E_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00373">
        <property type="entry name" value="TIGR00373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG90335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="174" mass="20265" checksum="7E4158D78344E964" modified="2019-02-13" version="1">MAFEDLLEDPVIQKYLHELVGPKGMPVAAAPPDGEVTDEELAEELDLELNDVRRALFILYENDLASYRRLRDEDSGWLTYLWTFEYDNIPENLEEEMYRLTDALEQRQEYERNHEFYLCEICSIRFEFGEAMDFGFECPECGSPLESMDNDRLVDAMEGRLAALEDELNIDADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P4M7</accession>
    <name>A0A3N6P4M7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_08515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90365">
        <property type="protein sequence ID" value="RQG90365"/>
        <property type="gene ID" value="EA462_08515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG90365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="74" mass="8337" checksum="6916A8E7C5C039F7" modified="2019-02-13" version="1">MDDIEYVREENVIHLWSAIISAAVSVVIPIVGILAAYSGYRLTTMMTRRWFGLLFAAFGLTSLASWLLWLLGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P677</accession>
    <name>A0A3N6P677_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TlpA family protein disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91235">
        <property type="protein sequence ID" value="RQG91235"/>
        <property type="gene ID" value="EA462_04390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="194" mass="20735" checksum="4EFE04922B883DF8" modified="2019-02-13" version="1">MKRRSLIVGSVGLCGLSGCLDDSSVDEPSDSTATSSDDDSLEPPFTIRTVDAPGSPAGEMTVPRSGALLVNFTRMACPTSAEMLSTLGTVSDTLSDDHDHDSGDAPVRLLSVTDPTRGLSPSETELAEWWDDNDGRWPVGIDSDGRLNRYYDVAGFPMTIIIDSEGTVHWRNRRGTTANNVLTAIDTVLEDGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P685</accession>
    <name>A0A3N6P685_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF354 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_04440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91245">
        <property type="protein sequence ID" value="RQG91245"/>
        <property type="gene ID" value="EA462_04440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007152">
        <property type="entry name" value="DUF354"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39662">
        <property type="entry name" value="PTHR39662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04007">
        <property type="entry name" value="DUF354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG91245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="366" mass="40718" checksum="E7DC2559F654DCFF" modified="2019-02-13" version="1">MRILVFANTPAHVHLYRHAVSRLEGAGHEVLVLTREYACTTDLLEFFGLPYRRYGTHETAAPSKPRLARELTEQAARITSQSLRFRPDVVFGRGPYAALAGTIARAPTVLVLDDEPGDFNHTVSRPFADCILSPAVTRRDLGSDHYTFEGFKECAYLHPAVFEPDGAVREYLGVGADEPFALVRFNALDALHDGGLEGFKSRERRELVERLSERATVFVSDESGEMDLSGLPARPYDLHPALIHDAMAEASLLVADTGTMVNEAALLGTPALRYRGSDDHEYGEFRELERVGLAEQFDEYAAVRDRALALLTDETADERWQRRRREYVGGLTDLTDLLVDVATARGTLERVTDRTRDALAPRSASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6I0</accession>
    <name>A0A3N6P6I0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Divalent-cation tolerance protein CutA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_05385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91405">
        <property type="protein sequence ID" value="RQG91405"/>
        <property type="gene ID" value="EA462_05385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="107" mass="12206" checksum="F377B9DDFEA9C599" modified="2019-02-13" version="1">MTTVYITAPPEEAERIARVLVEERLAACVNRIPTTSTYRWDGEIHHDDEVVLLAKTTDTVYAELENRVLEIHPHEVPCIERFDESHALESFAEWRGEVTQPSSGESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6M6</accession>
    <name>A0A3N6P6M6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_05960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91505">
        <property type="protein sequence ID" value="RQG91505"/>
        <property type="gene ID" value="EA462_05960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG91505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="281" mass="29365" checksum="7667B681CB6B91DB" modified="2019-02-13" version="1">MTDAGAASRLALFAREDVRDAVRERQAHVLGVLFVLLGGGLAYSAGRTAQMVSAEIELVGRLVGPLALLIPLVALGLVAPAIVEKRATGALTVLLGLPFSRRTVVLGTVLGRTIVIAAGALASLIVAVPIALMMGVSVDPVDLLGVALAFGVLAVTFTAIAVAISTLTRTSTRASFGAFGTYVVFVFGLWAQLPMLALYVVSGFEYPETVPTWVEFVSALNPMTAFTNLGGAVSPLENVAFSSVPTEPAVYERPSAALVILLAWIGVSVWVSILRFERTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P6S1</accession>
    <name>A0A3N6P6S1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TrmB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_06315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91565">
        <property type="protein sequence ID" value="RQG91565"/>
        <property type="gene ID" value="EA462_06315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="2">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Regulator_TrmB" evidence="3">
        <location>
            <begin position="120"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="264" mass="29111" checksum="608DB6E14EFF4429" modified="2019-02-13" version="1">MNENPSDEPYKVAISQLEAVGLSAYAARTFVALATLGEGTAQDVSDISEVPRTRVYDAVNELEDRGLVDVHQSTPKRFWVISSETTGRIFEQEYSQRVSELVAALDSLEPVARSDEQRGVWTVTGRKTVATRVIDFIESADEEVVYMTVGDLLTGDTIDSLRAASERGVSIKLGTMEQTIQEDIREAIPEAEMFESLWVWSDTPAGRLLMVDNEKTLVSVLADGTGDNQLEREDETAIWGSGGTNSLVIVLKAMFTWQLNGNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9G4</accession>
    <name>A0A3N6P9G4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_01175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92865">
        <property type="protein sequence ID" value="RQG92865"/>
        <property type="gene ID" value="EA462_01175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="120" mass="13572" checksum="36202AA8F9104B2C" modified="2019-02-13" version="1">MTASPHPESDRVEFVRAVLEWLDGRETRADAVDASLELLANERRRLFLQVMRTYGEALTLPDAAEEVAVRETGTSVAELSPEHVANVYISLYHDHMPRLIDAGLLEYDQERDLVTPVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9H4</accession>
    <name>A0A3N6P9H4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_01285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="4"/>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92885">
        <property type="protein sequence ID" value="RQG92885"/>
        <property type="gene ID" value="EA462_01285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="6">
        <location>
            <begin position="90"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG92885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="354" mass="39639" checksum="5586F369DBBA1170" modified="2019-02-13" version="1">MTSDDGERHRQGRLFTDDDGGFDAERARDESLPVEDGELIDTDELADHQRYVEGRGIYDERNRINDLTGKEWKYATKSVIAEGYPPAVQHDLRSEHGGQKPPRLCATLIGRFSKAGDAVLDPFAGVGGTLLGASFCEHEGTGRREAIGFERTERWIDIYETVLERENEARAERGDPPLAGQEMRHGDCADLIEDVPDDSIDLLLTDVPYWHMDELEQTRNERATRASKLGSFDEDDADSADEDGRDSAIDSTGERQTKAEWLADMAEKFERFTDAVAPGGHLVVFIGDMYREQSYEFLSADLARAIESAAPVTLAATLVWYDPTKDLHVYGYPFSFVPSMVHQNVLVFRPDGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHR0</accession>
    <name>A0A3N6LHR0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoate--protein ligase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86724">
        <property type="protein sequence ID" value="RQG86724"/>
        <property type="gene ID" value="EA462_16440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="27"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="224" mass="24393" checksum="A9B520B49C62FB2E" modified="2019-02-13" version="1">MRVIRGETQSLEADTAVTISLLERTAHDRTPVVRVWHPHRQVAFGRRDTNARQYDSARQIARREGFEPVERTVGGRAVAHTGTTVAFARCVPIDDPRTGLNERYESTSSDVRTALVELGVDARRGEPDDSFCPGTHSFRANGKLVGIAQRVRNDAALVSGIVLVRDHGEIARVLSPVYDALEVPFDPQSVGSLARAGGETDPAVVRSVLEDALTGTSCPSIEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LHT0</accession>
    <name>A0A3N6LHT0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chemotaxis protein CheA</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">EA462_16655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86764">
        <property type="protein sequence ID" value="RQG86764"/>
        <property type="gene ID" value="EA462_16655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010808">
        <property type="entry name" value="CheA_P2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07194">
        <property type="entry name" value="P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="9">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="325"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="8">
        <location>
            <begin position="549"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="5">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RQG86764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="676" mass="73074" checksum="719E4B56638ABB7C" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJ45</accession>
    <name>A0A3N6LJ45_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_14655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG88086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88086">
        <property type="protein sequence ID" value="RQG88086"/>
        <property type="gene ID" value="EA462_14655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG88086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="327" mass="35275" checksum="50FF18F171FB0BDD" modified="2019-02-13" version="1">MTDWNTNAELAEWCRLPMPFEASSVSPNGRWAAVSMSESCGIIDLRTETGLYEIARLGWEDYDEDDGTTFHALGSAFGANSEFVAFTRENEILVYATPEHTGKPNATGWKRHWTGELEGTVTDVSVGNSGKTLGGVTESGELALYGRFPEFGSIGPAETVSQEPLEFVAINPERKLVLCGGASGTVRLVRPNQKGGSEITAIDSDAEVEDGYWQTNNEFVFCDHSGDVTWCRIGQKSDRIGVTEIISTTIGTPRAVRVTDDGAWLLVGGDNGVEVFDIRDWQGTGQPDTERTIDTGECRTLAVGASVLAGGGNETDSFLKMIETPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LJR2</accession>
    <name>A0A3N6LJR2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor 1-alpha</fullName>
            <shortName evidence="6">EF-1-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Elongation factor Tu</fullName>
            <shortName evidence="6">EF-Tu</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tuf</name>
        <name evidence="8" type="ORF">EA462_11375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88983">
        <property type="protein sequence ID" value="RQG88983"/>
        <property type="gene ID" value="EA462_11375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="3"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="89"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG88983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="420" mass="45631" checksum="B58948F7D7819CAB" modified="2019-02-13" version="1">MSEQHQNLAIIGHVDHGKSTLVGRLLYETGSVPEHVIEQHREEAEEKGKGGFEFAYVMDNLAEERERGVTIDIAHQEFSTDEYDFTIVDCPGHRDFVKNMITGASQADNAVLVVAADDGVAPQTQEHVFLARTLGIDELIIGINKMDIVDYKEDTYEDVVDEVTQLLQQVQFNTDDAEFIPISAFEGDNIADTSDNTSWYDGNILLDALNALPEPEPPTDAPLRLPIQDVYTISGIGTVPVGRIETGVMNVGDNVSFQPSDVGGEVKTIEMHHEEVPKAEPGDNVGFNVRGLGKDDIRRGDVCGPADEPPSVAETFQAQVVVMQHPSVITAGYTPVFHAHTAQVACTIESIDKKMDPSSGEVAEENPDFIQSGDAAVVTIRPQKPLSIEPSSEIPELGSFAIRDMGQTIAAGKVLSVNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LKM3</accession>
    <name>A0A3N6LKM3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_15295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG87008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87008">
        <property type="protein sequence ID" value="RQG87008"/>
        <property type="gene ID" value="EA462_15295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="261" mass="27384" checksum="9DA93558CAB2B60F" modified="2019-02-13" version="1">MRASVSSDRDPVVDTGEYDGSGFNGLDPVAGSSTIARGYPMTNEYDDERPTTDLIDESDAIDEFGLPNAAETAASMVGNGLDERTVALAAGGVVLLSALRSLRRRRLGAVPKTIAGGALVGYGLRARRSVEEATTDSSTEMESAAADEESRIEFTEATEESEPRSKPTLEADDTRDPRRNTDDDRVSIDVSDSATADEVGEAAGPDPEQAQPTQTDSIEPEETPDEDTPHSTGESADGSDGNDDPEHADGADSTDAGPDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLC4</accession>
    <name>A0A3N6LLC4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_13585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87890">
        <property type="protein sequence ID" value="RQG87890"/>
        <property type="gene ID" value="EA462_13585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002860">
        <property type="entry name" value="BNR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02012">
        <property type="entry name" value="BNR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG87890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="353" mass="39174" checksum="CC5CE5C22727645C" modified="2019-02-13" version="1">MTLLMGTDDGLFRAEDVPFEKADAERILDCGRVTQVEDLTHAEGVFICSSDGAYRSLDGGETWSELAVPKGGRYWFEGDSIVFSLQATADGTLYAGTNLPALYRSFDDGETWHELRGFQDLPSRPHWESPEDPKRARIRNIESAPNTTDRLIVSLEVGGVHVSNDGGETWIDRRENIEDDVHHVLPLTADCWLAATGYFDLELEHVGLQTGLGHATGWGGLYRTTDAGETWKRLDQGNEYSYIRRAFTHDGTVIFSGANGAPPAWENDEHEAALFESTDFGRTFERVSYPGEPNEVIEDWVVDDDGTLLCGGGLFDIPDPRHDLDGRIMRRTDDGTYETVGKVPSSVGRIELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LLW3</accession>
    <name>A0A3N6LLW3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89908">
        <property type="protein sequence ID" value="RQG89908"/>
        <property type="gene ID" value="EA462_07810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="129" mass="14877" checksum="6EF7C1F977B8CA97" modified="2019-02-13" version="1">MTIERVRDTKHVIERWDDIFTALSAEPRRQLIVTLMNAPAGRRVLLPDAATTAADSFDLEQLRIQLIHHHLPMLAECGFVDWSTDPFCAQRGVRFVEVATIFTALEARIDEIPDQLIDGYQRFEEKRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LMQ8</accession>
    <name>A0A3N6LMQ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_12045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG89097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89097">
        <property type="protein sequence ID" value="RQG89097"/>
        <property type="gene ID" value="EA462_12045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="124" mass="13980" checksum="FECD145AF824C7F3" modified="2019-02-13" version="1">MHFDQRTQRALRDVGLETDELQAASESVVDAVEADAAALEAFFDAHDVVHSDMDMAHSASEHPEHAVERLDLTTHANEMRGWLRFDSWGAFVENGRILDDDLVELTLGPTIHDRVRFAPDRETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LNX3</accession>
    <name>A0A3N6LNX3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_13625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87897">
        <property type="protein sequence ID" value="RQG87897"/>
        <property type="gene ID" value="EA462_13625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="75"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG87897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="358" mass="38667" checksum="964931EEE575A990" modified="2019-02-13" version="1">MTDKANRRNVLTAVGAGLTIGVAGCAGDDNGNGNGTGNGNGNGGATGDDDGNGDGDDVLPDTLRLAHPGPTRPTYAAPQYAYFLEEMESRGVTIEPVTFDGFSPMIAGMISGDVEIGYVTPPSLANAIAEGFPVSSFMELSQAFSQQICTAPGIDSWDEIEGETFILHSPSSFSAMVGRNAVEANLGDPEAVEYQYIAGTPNRVAAIEAGEGVATTAFLGGVLDAEEEGIIQHFSNPNDDFDHMTLATWATLDENLDQNEEMFQIFADVMLEAYEDMYERDLTEIVELIENAPTDFPGYSEEVWVDTFEIALENEMFPLDLDDHITDEKFTTSLELAERAELIEEVPDIDDLVDRRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LS80</accession>
    <name>A0A3N6LS80_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_00510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG92748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG92748">
        <property type="protein sequence ID" value="RQG92748"/>
        <property type="gene ID" value="EA462_00510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043830">
        <property type="entry name" value="DUF5807"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19123">
        <property type="entry name" value="DUF5807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG92748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="143" mass="15639" checksum="A5D892D4DC6F9F66" modified="2019-02-13" version="1">MTTRREAFLAGDRLEDVALFLADSYVTDDRLEEFGERINDGVLIVVDGERGRSAFRAATGTDAMEFAQSAMGLEGEIDGDLTDGHCPETADTDETHDVQFVFAFAEERNEDVGGIYADGDVVHAYARCGCGTAYSDRWNVVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LSG8</accession>
    <name>A0A3N6LSG8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_09575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90224">
        <property type="protein sequence ID" value="RQG90224"/>
        <property type="gene ID" value="EA462_09575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG90224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="283" mass="30347" checksum="4A5E154724D4C15F" modified="2019-02-13" version="1">MPDGIDTVDGTDRPSSRQIALAQIRIEAGALEDNLERAIAAIEDAASRGADLVALPELFTVGYFAFDLYGRYAEAIEGETLSRVSEAAGDAGIAVLAGTIVEDLAATDSVETPAADGLANTAVLFDADGDRRLVYRKHHLFGYESAESELLVPGETIETATVGGVTVGVTTCYDLRFPTLYRRLVDAGVELVLVPSAWPYPRLEHWHTLSRARAIENQCYVATINGSGAFDDATLLGRSTVYDPWGVSRASSGDEPALVTAEVDPKAVADVRTEFPSLRDRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LT34</accession>
    <name>A0A3N6LT34_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalamin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93163">
        <property type="protein sequence ID" value="RQG93163"/>
        <property type="gene ID" value="EA462_02875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="294" mass="32157" checksum="310C087386FAB4FC" modified="2019-02-13" version="1">MNVISTSPSSTEILYELGVEPVAVSHACDHPPAATELPTIDVSKVDASASADRHEQVRTATANGHLYRMDGERIDALEPDLIVTQGVCGVCAVDDVLVEETLADLAVDPDVLALQANRLADVLECVEDVGRATATEERATALVDDLRERIAGVERRVPDEPRPRTAVLEWMDPIRPAGSWVPDVVDAAGGEYDIGDPGERSQPLEWDAFLAYDPEVLVVAPCGFDAERTLEQFHELSDRPGWDEITAVRDDRVFVLDGSAYLTRWTPRLVDAIERLAALCHSEEFELPADVVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LXH5</accession>
    <name>A0A3N6LXH5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KaiA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_16640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000007">
        <property type="protein sequence ID" value="RQG86761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86761">
        <property type="protein sequence ID" value="RQG86761"/>
        <property type="gene ID" value="EA462_16640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG86761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="236" mass="26021" checksum="8CD03D3AED18575D" modified="2019-02-13" version="1">MRITTGVSGFDTLVGGGILKDRLYVISGPPGSGKTTFCSQFVTKGAIDGETTLFLTLHETEEELVSDMGNYEFGFDQAVNSGHVKVLNAFENEAQRLLAPASRNSGEFPTSVENLANQLVAFIESKGVDRLVIDSTMLLEYYFSDELDTLIKFLTKLKRADATVLLISEMTDPTSYSDGHYLAHGVIFMHNYLEAGGMTRGVQIIKMRGTQIDCDIRKVEFTDRGLQVDPNEKVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6LZA7</accession>
    <name>A0A3N6LZA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tryptophan-rich sensory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">EA462_03360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93244">
        <property type="protein sequence ID" value="RQG93244"/>
        <property type="gene ID" value="EA462_03360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PTHR10057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RQG93244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="166" mass="18376" checksum="AB141BE9BC1C2FE2" modified="2019-02-13" version="1">MATRTSTPRVPDRGSILRAVGFVILVNVVGSVPGVLSSPDSPWFRALEKPWFYPPEIAFPVVWTALFTLLGIALWLVWRADADGRRLALGLFVVQMAFNVAWTPAFFTLEAPLVALGVILVLWGLVVATIAAFRRVDRRAAALLVPYLAWVTFAAVLNFELWRLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M047</accession>
    <name>A0A3N6M047_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MaoC family dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87894">
        <property type="protein sequence ID" value="RQG87894"/>
        <property type="gene ID" value="EA462_13610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="158" mass="17965" checksum="0713517248C4A622" modified="2019-02-13" version="1">MPRRHTLSRMVDYFEDIEVGVRRELGSYRMSDDEIKEFAEQYDPLPIHTDAELASRSRHEGVIASGFHTFAATNRIVTENFKSNLAVIAGLGIDDLRWYNPVRPEDTLTAEMEVLEKRTSESDPNRGIFRLDVTASNQDGDDVISFVDTGMVEVRETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M096</accession>
    <name>A0A3N6M096_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_13915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000005">
        <property type="protein sequence ID" value="RQG87954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG87954">
        <property type="protein sequence ID" value="RQG87954"/>
        <property type="gene ID" value="EA462_13915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG87954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="93" mass="10209" checksum="6646D88BF42EEBC2" modified="2019-02-13" version="1">MTDHSIEIPSRDIEFEMSEDGNESILDAAEKYGLDLPYQCRMGHCGICAMHASGEISQEDAMMLTPNEEADGYILTCVATPCSDVELHPDDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M345</accession>
    <name>A0A3N6M345_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_09840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90270">
        <property type="protein sequence ID" value="RQG90270"/>
        <property type="gene ID" value="EA462_09840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="340"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG90270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="489" mass="52013" checksum="F09F3E0A8F0DB325" modified="2019-02-13" version="1">MNTREHIVRGFKATLVARAIYMLSSALLMFVLARYLLDPDGYGALYWTIGILAVVQLCADLGFGKSLARYVSEYNESDPGQIPHLLRTVVSYKLAALGVVCGALLLFYEQIAVFLGDPNAAPFLAAGVLYVIVNSFNVFSQIAFQGFNRLGYSAAVQAIGGATRLLFAVAFVLLGLGALGALLGYVVGYAIAATFGLTVLYFQFYRTYEPAETYEEGLSRRLAEYSVPLTATRSANVVDKQIDTVLVGVFLTPAAVAFYTLGKQITDFVLAPAESLGFTISPNFGEQKATGKLEQAREIYETSLTHTMLVYIPAATGLVIVAEPFITMVFGADYAGAVPVLQILAGFIVLQAITNLTSDSLDYLGRARARAVAKGGTAAANFGLNILLIPTMGVVGAAIATVLTHSVYVVVNLYIVHLELSLRVGRLARSIALICTITAAMAVAVSLVTPLISNVVMLLIAIGLGACTWAALVIASGFVDPREVRSIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M8T5</accession>
    <name>A0A3N6M8T5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_07690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG89886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG89886">
        <property type="protein sequence ID" value="RQG89886"/>
        <property type="gene ID" value="EA462_07690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG89886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="72" mass="7715" checksum="9ECDD178BEC5A712" modified="2019-02-13" version="1">MTNPDSDDGDPQVPIVCGECETGSRVPLSDLADSIERHNEQLHDGDDVAEVDPDVADRIADLIAEELGLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6M9U8</accession>
    <name>A0A3N6M9U8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">EA462_02420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93080">
        <property type="protein sequence ID" value="RQG93080"/>
        <property type="gene ID" value="EA462_02420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RQG93080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="139" mass="15039" checksum="B3227079EC3A7FE8" modified="2019-02-13" version="1">MPPVDFRQSQSDIDSGHPAIHCNECQSALQSDSQQAVSFLLLDQLTIPIVSCDDHLERFASVCGLTTEDTATLLDHRPAGGICCPGCRLARYNAAQPMVPVEEGAIVAMACPTHQTEIVQRFHTGLETQHHLSSDVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MA30</accession>
    <name>A0A3N6MA30_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93180">
        <property type="protein sequence ID" value="RQG93180"/>
        <property type="gene ID" value="EA462_02980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="61" mass="6660" checksum="D3FCBDCCDBA62965" modified="2019-02-13" version="1">MIDSRGALEVETLLKIVLALVAVLLALQIVGIVVGWIAQLLTPILLLIVALVVVLWLYDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MGF3</accession>
    <name>A0A3N6MGF3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstA</name>
        <name evidence="8" type="ORF">EA462_02095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93026">
        <property type="protein sequence ID" value="RQG93026"/>
        <property type="gene ID" value="EA462_02095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="92"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG93026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="308" mass="33379" checksum="5C7C78B4AAB640C7" modified="2019-02-13" version="1">MSTDTDTEPTSTAADESLFTDVDLGWEHRKNRIFLAVIFAASMFGVVMLALLLLDVLTDLYVGVTEYNISLLEFFTRDGSRREELSGFRGAIVASIMLMIVTAILSFFVGVGSAIYLEEYAPDTRITRLIEANLANLAGVPSIVYGLLALAAFVNGIGMGPILLAGAIALALLVMPIIIVSTQEALRAVPDGVRNGSYATGATEWQTIRRVVLPAAMPGIMTGTILALARAIGETAPLIMVGAIFVNRMPFGPFDRFSAMPTQIYNWANEPSMHFIHLAAVGIVVLLTFMFVMNGIAIYLRNEYETEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MRP6</accession>
    <name>A0A3N6MRP6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S1 RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">EA462_14900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000006">
        <property type="protein sequence ID" value="RQG86943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG86943">
        <property type="protein sequence ID" value="RQG86943"/>
        <property type="gene ID" value="EA462_14900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RQG86943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="717" mass="78087" checksum="D1D9D9DE1496C970" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6MXM8</accession>
    <name>A0A3N6MXM8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">EA462_09850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000003">
        <property type="protein sequence ID" value="RQG90272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG90272">
        <property type="protein sequence ID" value="RQG90272"/>
        <property type="gene ID" value="EA462_09850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007036">
        <property type="entry name" value="Aste_AspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043795">
        <property type="entry name" value="N-alpha-Ac-DABA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04952">
        <property type="entry name" value="AstE_AspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039012">
        <property type="entry name" value="ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RQG90272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="364" mass="39888" checksum="F5B38014A6E9CC9A" modified="2019-02-13" version="1">MNDEASSGEAPDGRSDSDSIEGVFTYNGGRVDPGESTNIRYSISETYLGDPVKIPVTVINGRHPGPTVFLSAAAHGDELNGIEVVREVAHDWDHSELYGTLICLPVMNVPGFLAQERYLPIYDRDLNRSFPGREGSTSARRMAHEIFTNFIEPCDLGIDFHTSTRGRTNMLHVRADMSDSIVSRLANAYSSNVIIAGDGASGTLRREATEAGIPTITVEMGEAHRFQRRLIDRALTGVASVLAEFGLHRDSSVHWPGWRTIIDDDDEKTWLRADAGGIVDMKQGRGALVEEDDVICTITNPFKEEDEVVTVDAPFTGLIVGVLENPVVYPGNPLCHLVGLSPDTRIALERERTAERSRADLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6N0F1</accession>
    <name>A0A3N6N0F1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADP-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">EA462_05190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91372">
        <property type="protein sequence ID" value="RQG91372"/>
        <property type="gene ID" value="EA462_05190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012188">
        <property type="entry name" value="ME_PTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036684">
        <property type="entry name" value="ME_PTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="7">
        <location>
            <begin position="16"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="6">
        <location>
            <begin position="161"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RQG91372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="751" mass="81395" checksum="34BB98EA14CF5815" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWL8</accession>
    <name>A0A3N6NWL8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional oligoribonuclease/PAP phosphatase NrnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_11190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88949">
        <property type="protein sequence ID" value="RQG88949"/>
        <property type="gene ID" value="EA462_11190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DHH" evidence="2">
        <location>
            <begin position="80"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="3">
        <location>
            <begin position="280"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG88949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="404" mass="43191" checksum="E6A2399144C079B6" modified="2019-02-13" version="1">MNDPSTSTRQVLSLGERSLEAGTSSFEAGVDTLQSLDPLVLSLLILAIVAVLLGGWWLVRWFRRPAGVRLQRLLSSYDEVAVLMHPNPDPDAMACAMGVAAIADSVDTETTLQYSGEIRHQENRAFRTVLELDLENVESSSELAADAVVLVDHNTARGFTGAQTIEPVAVVDHHPGNGTGTKFTDVRTEYGAASTIFVEYVGEIGATKVTDDEDTGSGLTLSPELATGLLYGIQADTNHLTNGCSNAEFDAAAYLFDAIDEDLLERIANPQVSDDVLQIKATAITEKRVEGSFAICDVGLISNVDAIPQAADELMHLEGVTAVVVYGESDGTIHLSGRSRDDRVHMGETLRHAVSDIPMANAGGHARMGGGQLSVDHMRGIGPSDGIDRTEFEERLFSALSGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6NWN9</accession>
    <name>A0A3N6NWN9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_11355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000004">
        <property type="protein sequence ID" value="RQG88979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG88979">
        <property type="protein sequence ID" value="RQG88979"/>
        <property type="gene ID" value="EA462_11355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG88979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="540" mass="57503" checksum="24B155EE36AABDBF" modified="2019-02-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P0X6</accession>
    <name>A0A3N6P0X6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterio-opsin activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">EA462_03795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91129">
        <property type="protein sequence ID" value="RQG91129"/>
        <property type="gene ID" value="EA462_03795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031803">
        <property type="entry name" value="BAT_GAF/HTH-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15915">
        <property type="entry name" value="BAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BAT" evidence="4">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="HTH bat-type" evidence="3">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RQG91129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="216" mass="24332" checksum="12108622F6D2E2E1" modified="2019-02-13" version="1">MSDSRVIAELTLVHPELVLTPTIEAVPEMTIELEYQAIASPESYFLFFEVCGNHLDRFDRAIESDRTVSEPTALIDDDECRIYRVRVSSLDRLVLPRAAELGIRVLRTEAGSGGWIPTLEIPELEALQEFRAYCERREISFSVDRLYHAEKGERAGEFGLTPIQRETLLVAYEEGYFDDPRGTSMADLAETLGVSSSAVSGRLRRGMETLIENTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P182</accession>
    <name>A0A3N6P182_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_04410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91239">
        <property type="protein sequence ID" value="RQG91239"/>
        <property type="gene ID" value="EA462_04410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG91239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="178" mass="20148" checksum="A9C2C236FB94EB87" modified="2019-02-13" version="1">MSEHELTQAELFDVFSNARRRHAVQYLKRKGGSCDLAPLVEQVAAWENDTPPDDVTRTQRRRVYISLYQTHLPMLEDHGIVDWDPEAHAIELLPSEEVFEPYLDRRLGSERPWHRLYVTAATVGVIAFGLGWLSIGPATNEVVPVVALGLCLVVFALSVAQYVSRRPDLEVPFVRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P1Y8</accession>
    <name>A0A3N6P1Y8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">EA462_06340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000002">
        <property type="protein sequence ID" value="RQG91569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG91569">
        <property type="protein sequence ID" value="RQG91569"/>
        <property type="gene ID" value="EA462_06340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="167"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RQG91569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="326" mass="37957" checksum="2C04CC788F42D1B9" modified="2019-02-13" version="1">MGRNMLVDGEWKTDIEPHTDEDGAFDRVETSFRDWIRDESDARFQPEDDRYHLYIARNCPWAHGTALTLQLTGLTDAISIDIVDPWREDDGWKFTPEKNGCTPDTVSGCEYLREVYVNADPEFTGRVTVPVLWDKREETIVNNESIEIMRMFATEFDEYADGVDLYPEGYRDEIDRIIDDVYDSINNGVYRAGFADSQGAYDEAVRDVFDGLDHYDEVLADRRYLAGDRLTLADVRLFPTLIRFDAAYHTAFKCDKQYLHQYDNLWPYLRDLYQTPGVAETVVMDHIRDEGYFQGEITSIGPDLDFEAPHDRDRLPSREPDTRYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2021-04-07" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A3N6P9X3</accession>
    <name>A0A3N6P9X3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">EA462_02560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Natrarchaeobius halalkaliphilus</name>
        <dbReference type="NCBI Taxonomy" id="1679091"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>Stenosarchaea group</taxon>
            <taxon>Halobacteria</taxon>
            <taxon>Natrialbales</taxon>
            <taxon>Natrialbaceae</taxon>
            <taxon>Natrarchaeobius</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-10" db="EMBL/GenBank/DDBJ databases">
            <title>Natrarchaeobius chitinivorans gen. nov., sp. nov., and Natrarchaeobius haloalkaliphilus sp. nov., alkaliphilic, chitin-utilizing haloarchaea from hypersaline alkaline lakes.</title>
            <authorList>
                <person name="Sorokin D.Y."/>
                <person name="Elcheninov A.G."/>
                <person name="Kostrikina N.A."/>
                <person name="Bale N.J."/>
                <person name="Sinninghe Damste J.S."/>
                <person name="Khijniak T.V."/>
                <person name="Kublanov I.V."/>
                <person name="Toshchakov S.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AArcht-Sl</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="REFY01000001">
        <property type="protein sequence ID" value="RQG93105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="RQG93105">
        <property type="protein sequence ID" value="RQG93105"/>
        <property type="gene ID" value="EA462_02560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000273828">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RQG93105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000273828"/>
        </source>
    </evidence>
    <sequence length="165" mass="17810" checksum="772D97104D9746D9" modified="2019-02-13" version="1">MEQSREELWPYFTDPDVLAECAPGCTEMVLESPHEITAVLAVGVGSVKPEFNVDAIVTRLEHPELLELKAEGNAPRNEFELTATMEMIGRDDGGTTVAWQANADVSGTIVSLGGRALQSVTNRLVKKYFADMQAAVESGEGAESKLETAPQEVLEDVDTDLEEAA</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>